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Frontal cognitive impairments and saccadic deficits in low-dose MPTP-treated monkeys. (1/9619)
There is considerable overlap between the cognitive deficits observed in humans with frontal lobe damage and those described in patients with Parkinson's disease. Similar frontal impairments have been found in the 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine (MPTP) primate model of Parkinsonism. Here we provide quantitative documentation of the cognitive, oculomotor, and skeletomotor dysfunctions of monkeys trained on a frontal task and treated with low-doses (LD) of MPTP. Two rhesus monkeys were trained to perform a spatial delayed-response task with frequent alternations between two behavioral modes (GO and NO-GO). After control recordings, the monkeys were treated with one placebo and successive LD MPTP courses. Monkey C developed motor Parkinsonian signs after a fourth course of medium-dose (MD) MPTP and later was treated with combined dopaminergic therapy (CDoT). There were no gross motor changes after the LD MPTP courses, and the average movement time (MT) did not increase. However, reaction time (RT) increased significantly. Both RT and MT were further increased in the symptomatic state, under CDoT. Self-initiated saccades became hypometric after LD MPTP treatments and their frequency decreased. Visually triggered saccades were affected to a lesser extent by the LD MPTP treatments. All saccadic parameters declined further in the symptomatic state and improved partially during CDoT. The number of GO mode (no-response, location, and early release) errors increased after MPTP treatment. The monkeys made more perseverative errors while switching from the GO to the NO-GO mode. Saccadic eye movement patterns suggest that frontal deficits were involved in most observed errors. CDoT had a differential effect on the behavioral errors. It decreased omission errors but did not improve location errors or perseverative errors. Tyrosine hydroxylase immunohistochemistry showed moderate ( approximately 70-80%) reduction in the number of dopaminergic neurons in the substantia nigra pars compacta after MPTP treatment. These results show that cognitive and motor disorders can be dissociated in the LD MPTP model and that cognitive and oculomotor impairments develop before the onset of skeletal motor symptoms. The behavioral and saccadic deficits probably result from the marked reduction of dopaminergic neurons in the midbrain. We suggest that these behavioral changes result from modified neuronal activity in the frontal cortex. (+info)Non-motor associative learning in patients with isolated degenerative cerebellar disease. (2/9619)
In recent decades it has become clear that the cerebellum is involved in associative motor learning, but its exact role in motor learning as such is still controversial. Recently, a contribution of the cerebellum to different cognitive abilities has also been considered, but it remains unclear whether the cerebellum contributes to cognitive associative learning. We compared nine patients with an isolated cerebellar degenerative disease in a cognitive associative learning task with 10 controls. Patients and controls were matched for age, sex, handedness, level of education, intelligence and capabilities of visual memory. The subjects were asked to learn the association between six pairs of colours and numerals by trial and error. Additionally, a simple reaction time and a visual scanning test were conducted in order to control for the influence of motor performance deficits in cerebellar patients. In comparison with the controls, it took the patients significantly longer to learn the correct associations between colours and numerals, and they were impaired in recognizing them later on. Two patients showed no associative learning effect at all. Neither the simple reaction time nor the visual scanning time correlated substantially with the results of associative learning. Therefore, motor-associated disabilities are unlikely to be the reason for the learning deficit in cerebellar patients. Our results suggest that the cerebellum might contribute to motor-independent processes that are generally involved in associative learning. (+info)The neuropsychopharmacology of phencyclidine: from NMDA receptor hypofunction to the dopamine hypothesis of schizophrenia. (3/9619)
Administration of noncompetitive NMDA/glutamate receptor antagonists, such as phencyclidine (PCP) and ketamine, to humans induces a broad range of schizophrenic-like symptomatology, findings that have contributed to a hypoglutamatergic hypothesis of schizophrenia. Moreover, a history of experimental investigations of the effects of these drugs in animals suggests that NMDA receptor antagonists may model some behavioral symptoms of schizophrenia in nonhuman subjects. In this review, the usefulness of PCP administration as a potential animal model of schizophrenia is considered. To support the contention that NMDA receptor antagonist administration represents a viable model of schizophrenia, the behavioral and neurobiological effects of these drugs are discussed, especially with regard to differing profiles following single-dose and long-term exposure. The neurochemical effects of NMDA receptor antagonist administration are argued to support a neurobiological hypothesis of schizophrenia, which includes pathophysiology within several neurotransmitter systems, manifested in behavioral pathology. Future directions for the application of NMDA receptor antagonist models of schizophrenia to preclinical and pathophysiological research are offered. (+info)Effect of iron-, iodine-, and beta-carotene-fortified biscuits on the micronutrient status of primary school children: a randomized controlled trial. (4/9619)
BACKGROUND: Deficiencies of iron, iodine, and vitamin A are prevalent worldwide and can affect the mental development and learning ability of schoolchildren. OBJECTIVE: The aim of this study was to determine the effect of micronutrient-fortified biscuits on the micronutrient status of primary school children. DESIGN: Micronutrient status was assessed in 115 children aged 6-11 y before and after consumption of biscuits (fortified with iron, iodine, and beta-carotene) for 43 wk over a 12-mo period and was compared with that in a control group (n = 113) who consumed nonfortified biscuits. Cognitive function, growth, and morbidity were assessed as secondary outcomes. RESULTS: There was a significant between-group treatment effect on serum retinol, serum ferritin, serum iron, transferrin saturation, and urinary iodine (P <0.0001) and in hemoglobin and hematocrit (P <0.05). The prevalence of low serum retinol concentrations (<0.70 micromol/L) decreased from 39.1% to 12.2%, of low serum ferritin concentrations (<20 microg/L) from 27.8% to 13.9%, of anemia (hemoglobin <120 g/L) from 29.6% to 15.6%, and of low urinary iodine concentrations (<100 microg/L) from 97.5% to 5.4%. There was a significant between-group treatment effect (P <0.05) in cognitive function with the digit span forward task (short-term memory). Fewer school days were missed in the intervention than in the control group because of respiratory- (P = 0.097) and diarrhea-related (P = 0.013) illnesses. The intervention had no effect on anthropometric status [corrected]. CONCLUSIONS: Fortified biscuits resulted in a significant improvement in the micronutrient status of primary school children from a poor rural community and also appeared to have a favorable effect on morbidity and cognitive function [corrected]. (+info)Cognitive outcome after unilateral pallidal stimulation in Parkinson's disease. (5/9619)
OBJECTIVES: Chronic high frequency electrostimulation of the globus pallidus internus mimics pallidotomy and improves clinical symptoms in Parkinson's disease. The aim of this study was to investigate the cognitive consequences of unilateral deep brain stimulation. METHODS: Twenty non-demented patients with Parkinson's disease (age range 38-70 years) were neuropsychologically assessed 2 months before and 3 months after unilateral pallidal stimulation. The cognitive assessment included measures of memory, spatial behaviour, and executive and psychomotor function. In addition to group analysis of cognitive change, a cognitive impairment index (CII) was calculated for each individual patient representing the percentage of cognitive measures that fell more than 1 SD below the mean of a corresponding normative sample. RESULTS: Neurological assessment with the Hoehn and Yahr scale and the unified Parkinson's disease rating scale disclosed a significant postoperative reduction in average clinical Parkinson's disease symptomatology (p<0.001). Repeated measures multivariate analysis of variance (using right/left side of stimulation as a between subjects factor) showed no significant postoperative change in cognitive performance for the total patient group (main effect of operation). The side of stimulation did not show a significant differential effect on cognitive performance (main effect of lateralisation). There was no significant operation by lateralisation interaction effect. Although the patients experienced significant motor symptom relief after pallidal stimulation, they remained mildly depressed after surgery. Analysis of the individual CII changes showed a postoperative cognitive decline in 30% of the patients. These patients were significantly older and took higher preoperative doses of levodopa than patients showing no change or a postoperative cognitive improvement. CONCLUSIONS: Left or right pallidal stimulation for the relief of motor symptoms in Parkinson's disease seems relatively safe, although older patients and patients needing high preoperative doses of levodopa seem to be more vulnerable for cognitive decline after deep brain stimulation. (+info)Dissociable deficits in the decision-making cognition of chronic amphetamine abusers, opiate abusers, patients with focal damage to prefrontal cortex, and tryptophan-depleted normal volunteers: evidence for monoaminergic mechanisms. (6/9619)
We used a novel computerized decision-making task to compare the decision-making behavior of chronic amphetamine abusers, chronic opiate abusers, and patients with focal lesions of orbital prefrontal cortex (PFC) or dorsolateral/medial PFC. We also assessed the effects of reducing central 5-hydroxytryptamine (5-HT) activity using a tryptophan-depleting amino acid drink in normal volunteers. Chronic amphetamine abusers showed suboptimal decisions (correlated with years of abuse), and deliberated for significantly longer before making their choices. The opiate abusers exhibited only the second of these behavioral changes. Importantly, both sub-optimal choices and increased deliberation times were evident in the patients with damage to orbitofrontal PFC but not other sectors of PFC. Qualitatively, the performance of the subjects with lowered plasma tryptophan was similar to that associated with amphetamine abuse, consistent with recent reports of depleted 5-HT in the orbital regions of PFC of methamphetamine abusers. Overall, these data suggest that chronic amphetamine abusers show similar decision-making deficits to those seen after focal damage to orbitofrontal PFC. These deficits may reflect altered neuromodulation of the orbitofrontal PFC and interconnected limbic-striatal systems by both the ascending 5-HT and mesocortical dopamine (DA) projections. (+info)The neural consequences of conflict between intention and the senses. (7/9619)
Normal sensorimotor states involve integration of intention, action and sensory feedback. An example is the congruence between motor intention and sensory experience (both proprioceptive and visual) when we move a limb through space. Such goal-directed action necessitates a mechanism that monitors sensorimotor inputs to ensure that motor outputs are congruent with current intentions. Monitoring in this sense is usually implicit and automatic but becomes conscious whenever there is a mismatch between expected and realized sensorimotor states. To investigate how the latter type of monitoring is achieved we conducted three fully factorial functional neuroimaging experiments using PET measures of relative regional cerebral blood flow with healthy volunteers. In the first experiment subjects were asked to perform Luria's bimanual co-ordination task which involves either in-phase (conditions 1 and 3) or out-of-phase (conditions 2 and 4) bimanual movements (factor one), while looking towards their left hand. In half of the conditions (conditions 3 and 4) a mirror was used that altered visual feedback (factor two) by replacing their left hand with the mirror image of their right hand. Hence (in the critical condition 4) subjects saw in-phase movements despite performing out-of-phase movements. This mismatch between intention, proprioception and visual feedback engendered cognitive conflict. The main effect of out-of-phase movements was associated with increased neural activity in posterior parietal cortex (PPC) bilaterally [Brodmann area (BA) 40, extending into BA 7] and dorsolateral prefrontal cortex (DLPFC) bilaterally (BA 9/46). The main effect of the mirror showed increased neural activity in right DLPFC (BA 9/ 46) and right superior PPC (BA 7) only. Analysis of the critical interaction revealed that the mismatch condition led to a specific activation in the right DLPFC alone (BA 9/46). Study 2, using an identical experimental set-up but manipulating visual feedback from the right hand (instead of the left), subsequently demonstrated that this right DLPFC activation was independent of the hand attended. Finally, study 3 removed the motor intentional component by moving the subjects' hand passively, thus engendering a mismatch between proprioception and vision only. Activation in the right lateral prefrontal cortex was now more ventral than in studies 1 or 2 (BA 44/45). A direct comparison of studies 1 and 3 (which both manipulated visual feedback from the left hand) confirmed that a ventral right lateral prefrontal region is primarily activated by discrepancies between signals from sensory systems, while a more dorsal area in right lateral prefrontal cortex is activated when actions must be maintained in the face of a conflict between intention and sensory outcome. (+info)Optical imaging of functional domains in the cortex of the awake and behaving monkey. (8/9619)
As demonstrated by anatomical and physiological studies, the cerebral cortex consists of groups of cortical modules, each comprising populations of neurons with similar functional properties. This functional modularity exists in both sensory and association neocortices. However, the role of such cortical modules in perceptual and cognitive behavior is unknown. To aid in the examination of this issue we have applied the high spatial resolution optical imaging methodology to the study of awake, behaving animals. In this paper, we report the optical imaging of orientation domains and blob structures, approximately 100-200 micrometer in size, in visual cortex of the awake and behaving monkey. By overcoming the spatial limitations of other existing imaging methods, optical imaging will permit the study of a wide variety of cortical functions at the columnar level, including motor and cognitive functions traditionally studied with positron-emission tomography or functional MRI techniques. (+info)Types of Cognition Disorders: There are several types of cognitive disorders that affect different aspects of cognitive functioning. Some common types include:
1. Attention Deficit Hyperactivity Disorder (ADHD): Characterized by symptoms of inattention, hyperactivity, and impulsivity.
2. Traumatic Brain Injury (TBI): Caused by a blow or jolt to the head that disrupts brain function, resulting in cognitive, emotional, and behavioral changes.
3. Alzheimer's Disease: A progressive neurodegenerative disorder characterized by memory loss, confusion, and difficulty with communication.
4. Stroke: A condition where blood flow to the brain is interrupted, leading to cognitive impairment and other symptoms.
5. Parkinson's Disease: A neurodegenerative disorder that affects movement, balance, and cognition.
6. Huntington's Disease: An inherited disorder that causes progressive damage to the brain, leading to cognitive decline and other symptoms.
7. Frontotemporal Dementia (FTD): A group of neurodegenerative disorders characterized by changes in personality, behavior, and language.
8. Post-Traumatic Stress Disorder (PTSD): A condition that develops after a traumatic event, characterized by symptoms such as anxiety, avoidance, and hypervigilance.
9. Mild Cognitive Impairment (MCI): A condition characterized by memory loss and other cognitive symptoms that are more severe than normal age-related changes but not severe enough to interfere with daily life.
Causes and Risk Factors: The causes of cognition disorders can vary depending on the specific disorder, but some common risk factors include:
1. Genetics: Many cognitive disorders have a genetic component, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease.
2. Age: As people age, their risk of developing cognitive disorders increases, such as Alzheimer's disease, vascular dementia, and frontotemporal dementia.
3. Lifestyle factors: Factors such as physical inactivity, smoking, and poor diet can increase the risk of cognitive decline and dementia.
4. Traumatic brain injury: A severe blow to the head or a traumatic brain injury can increase the risk of developing cognitive disorders, such as chronic traumatic encephalopathy (CTE).
5. Infections: Certain infections, such as meningitis and encephalitis, can cause cognitive disorders if they damage the brain tissue.
6. Stroke or other cardiovascular conditions: A stroke or other cardiovascular conditions can cause cognitive disorders by damaging the blood vessels in the brain.
7. Chronic substance abuse: Long-term use of drugs or alcohol can damage the brain and increase the risk of cognitive disorders, such as dementia.
8. Sleep disorders: Sleep disorders, such as sleep apnea, can increase the risk of cognitive disorders, such as dementia.
9. Depression and anxiety: Mental health conditions, such as depression and anxiety, can increase the risk of cognitive decline and dementia.
10. Environmental factors: Exposure to certain environmental toxins, such as pesticides and heavy metals, has been linked to an increased risk of cognitive disorders.
It's important to note that not everyone with these risk factors will develop a cognitive disorder, and some people without any known risk factors can still develop a cognitive disorder. If you have concerns about your cognitive health, it's important to speak with a healthcare professional for proper evaluation and diagnosis.
The term "schizophrenia" was first used by the Swiss psychiatrist Eugen Bleuler in 1908 to describe the splitting of mental functions, which he believed was a key feature of the disorder. The word is derived from the Greek words "schizein," meaning "to split," and "phrenos," meaning "mind."
There are several subtypes of schizophrenia, including:
1. Paranoid Schizophrenia: Characterized by delusions of persecution and suspicion, and a tendency to be hostile and defensive.
2. Hallucinatory Schizophrenia: Characterized by hearing voices or seeing things that are not there.
3. Disorganized Schizophrenia: Characterized by disorganized thinking and behavior, and a lack of motivation or interest in activities.
4. Catatonic Schizophrenia: Characterized by immobility, mutism, and other unusual movements or postures.
5. Undifferentiated Schizophrenia: Characterized by a combination of symptoms from the above subtypes.
The exact cause of schizophrenia is still not fully understood, but it is believed to involve a combination of genetic, environmental, and neurochemical factors. It is important to note that schizophrenia is not caused by poor parenting or a person's upbringing.
There are several risk factors for developing schizophrenia, including:
1. Genetics: A person with a family history of schizophrenia is more likely to develop the disorder.
2. Brain chemistry: Imbalances in neurotransmitters such as dopamine and serotonin have been linked to schizophrenia.
3. Prenatal factors: Factors such as maternal malnutrition or exposure to certain viruses during pregnancy may increase the risk of schizophrenia in offspring.
4. Childhood trauma: Traumatic events during childhood, such as abuse or neglect, have been linked to an increased risk of developing schizophrenia.
5. Substance use: Substance use has been linked to an increased risk of developing schizophrenia, particularly cannabis and other psychotic substances.
There is no cure for schizophrenia, but treatment can help manage symptoms and improve quality of life. Treatment options include:
1. Medications: Antipsychotic medications are the primary treatment for schizophrenia. They can help reduce positive symptoms such as hallucinations and delusions, and negative symptoms such as a lack of motivation or interest in activities.
2. Therapy: Cognitive-behavioral therapy (CBT) and other forms of talk therapy can help individuals with schizophrenia manage their symptoms and improve their quality of life.
3. Social support: Support from family, friends, and support groups can be an important part of the treatment plan for individuals with schizophrenia.
4. Self-care: Engaging in activities that bring pleasure and fulfillment, such as hobbies or exercise, can help individuals with schizophrenia improve their overall well-being.
It is important to note that schizophrenia is a complex condition, and treatment should be tailored to the individual's specific needs and circumstances. With appropriate treatment and support, many people with schizophrenia are able to lead fulfilling lives and achieve their goals.
There are several types of dementia, each with its own set of symptoms and characteristics. Some common types of dementia include:
* Alzheimer's disease: This is the most common form of dementia, accounting for 50-70% of all cases. It is a progressive disease that causes the death of brain cells, leading to memory loss and cognitive decline.
* Vascular dementia: This type of dementia is caused by problems with blood flow to the brain, often as a result of a stroke or small vessel disease. It can cause difficulty with communication, language, and visual-spatial skills.
* Lewy body dementia: This type of dementia is characterized by the presence of abnormal protein deposits called Lewy bodies in the brain. It can cause a range of symptoms, including memory loss, confusion, hallucinations, and difficulty with movement.
* Frontotemporal dementia: This is a group of diseases that affect the front and temporal lobes of the brain, leading to changes in personality, behavior, and language.
The symptoms of dementia can vary depending on the underlying cause, but common symptoms include:
* Memory loss: Difficulty remembering recent events or learning new information.
* Communication and language difficulties: Struggling to find the right words or understand what others are saying.
* Disorientation: Getting lost in familiar places or having difficulty understanding the time and date.
* Difficulty with problem-solving: Trouble with planning, organizing, and decision-making.
* Mood changes: Depression, anxiety, agitation, or aggression.
* Personality changes: Becoming passive, suspicious, or withdrawn.
* Difficulty with movement: Trouble with coordination, balance, or using utensils.
* Hallucinations: Seeing or hearing things that are not there.
* Sleep disturbances: Having trouble falling asleep or staying asleep.
The symptoms of dementia can be subtle at first and may progress slowly over time. In the early stages, they may be barely noticeable, but as the disease progresses, they can become more pronounced and interfere with daily life. It is important to seek medical advice if you or a loved one is experiencing any of these symptoms, as early diagnosis and treatment can help improve outcomes.
The symptoms of Alzheimer's disease can vary from person to person and may progress slowly over time. Early symptoms may include memory loss, confusion, and difficulty with problem-solving. As the disease progresses, individuals may experience language difficulties, visual hallucinations, and changes in mood and behavior.
There is currently no cure for Alzheimer's disease, but there are several medications and therapies that can help manage its symptoms and slow its progression. These include cholinesterase inhibitors, memantine, and non-pharmacological interventions such as cognitive training and behavioral therapy.
Alzheimer's disease is a significant public health concern, affecting an estimated 5.8 million Americans in 2020. It is the sixth leading cause of death in the United States, and its prevalence is expected to continue to increase as the population ages.
There is ongoing research into the causes and potential treatments for Alzheimer's disease, including studies into the role of inflammation, oxidative stress, and the immune system. Other areas of research include the development of biomarkers for early detection and the use of advanced imaging techniques to monitor progression of the disease.
Overall, Alzheimer's disease is a complex and multifactorial disorder that poses significant challenges for individuals, families, and healthcare systems. However, with ongoing research and advances in medical technology, there is hope for improving diagnosis and treatment options in the future.
Some common types of memory disorders include:
1. Amnesia: A condition where an individual experiences memory loss, either partial or total, due to brain damage or other causes.
2. Dementia: A broad term that describes a decline in cognitive function, including memory loss, confusion, and difficulty with communication and daily activities. Alzheimer's disease is the most common cause of dementia.
3. Mild Cognitive Impairment (MCI): A condition characterized by memory loss and other cognitive symptoms that are more severe than normal age-related changes but not as severe as dementia.
4. Attention Deficit Hyperactivity Disorder (ADHD): A neurodevelopmental disorder that affects attention, impulse control, and hyperactivity. Memory problems are often a component of ADHD.
5. Traumatic Brain Injury (TBI): A condition that occurs when the brain is injured due to a blow or jolt to the head, which can result in memory loss and other cognitive problems.
6. Stroke: A condition where blood flow to the brain is interrupted, leading to brain cell death and potential memory loss.
7. Meningitis: An inflammatory condition that affects the membranes covering the brain and spinal cord, which can lead to memory loss and other cognitive problems.
8. Encephalitis: An inflammatory condition that affects the brain directly, leading to memory loss and other cognitive problems.
9. Chronic Fatigue Syndrome (CFS): A condition characterized by persistent fatigue, memory loss, and other cognitive symptoms.
10. Sleep Disorders: Sleep disturbances can affect memory and cognitive function, including conditions such as insomnia, sleep apnea, and restless leg syndrome.
The diagnosis of memory disorders typically involves a combination of medical history, physical examination, laboratory tests, and neuropsychological evaluations. The specific treatment approach will depend on the underlying cause of the memory loss, but may include medication, behavioral interventions, and lifestyle changes.
The diagnosis of MCI requires a comprehensive medical evaluation, including a thorough history, physical examination, laboratory tests, and cognitive assessments. The goal of the diagnosis is to differentiate MCI from normal aging and other conditions that may cause similar symptoms, such as depression or medication side effects.
There are several subtypes of MCI, including:
1. Amnestic Mild Cognitive Impairment (aMCI): Characterized by memory loss, especially for episodic memory (memory of events and experiences).
2. Non-amnestic Mild Cognitive Impairment (naMCI): Characterized by cognitive impairment without memory loss.
3. Mixed Mild Cognitive Impairment (mMCI): Characterized by a combination of amnestic and non-amnestic symptoms.
The main risk factor for developing MCI is advancing age, but other factors such as family history, genetics, and lifestyle factors may also contribute to the development of the condition. There is currently no cure for MCI, but there are several treatment options available to slow down cognitive decline and improve quality of life. These include:
1. Cognitive training and rehabilitation: To improve memory, attention, and other cognitive functions.
2. Medications: Such as cholinesterase inhibitors, which can improve cognitive function and slow down decline.
3. Lifestyle changes: Such as regular exercise, social engagement, and management of chronic health conditions.
4. Alternative therapies: Such as cognitive training, mindfulness-based interventions, and herbal supplements.
Early detection and treatment of MCI can potentially delay progression to dementia, improve quality of life, and reduce caregiver burden. However, the exact timing and duration of these benefits are not yet fully understood. Further research is needed to understand the mechanisms underlying MCI and to develop more effective treatments for this condition.
In summary, mild cognitive impairment (MCI) is a condition characterized by cognitive decline beyond what is expected for an individual's age and education level, but not severe enough to interfere with daily life. There are three subtypes of MCI, and the main risk factor is advancing age. Treatment options include cognitive training and rehabilitation, medications, lifestyle changes, and alternative therapies. Early detection and treatment may potentially delay progression to dementia and improve quality of life.
The symptoms of vascular dementia can vary depending on the location and severity of the damage to the brain, but common symptoms include:
* Memory loss, such as difficulty remembering recent events or learning new information
* Confusion and disorientation
* Difficulty with communication, including trouble finding the right words or understanding what others are saying
* Difficulty with problem-solving, decision-making, and judgment
* Mood changes, such as depression, anxiety, or agitation
* Personality changes, such as becoming more passive or suspicious
* Difficulty with coordination and movement, including trouble walking or balance
Vascular dementia can be caused by a variety of conditions that affect the blood vessels in the brain, including:
* Stroke or transient ischemic attack (TIA, or "mini-stroke")
* Small vessel disease, such as tiny strokes or changes in the blood vessels that occur over time
* Moyamoya disease, a rare condition caused by narrowing or blockage of the internal carotid artery and its branches
* Cerebral amyloid angiopathy, a condition in which abnormal protein deposits build up in the blood vessels of the brain
* Other conditions that can cause reduced blood flow to the brain, such as high blood pressure, diabetes, or cardiovascular disease
There is no cure for vascular dementia, but there are several treatment options available to help manage its symptoms and slow its progression. These may include medications to improve memory and cognitive function, physical therapy to maintain mobility and strength, and lifestyle changes such as a healthy diet and regular exercise. In some cases, surgery or endovascular procedures may be recommended to treat the underlying cause of the dementia, such as a stroke or blocked blood vessel.
It is important for individuals with vascular dementia to receive timely and accurate diagnosis and treatment, as well as ongoing support and care from healthcare professionals, family members, and caregivers. With appropriate management, many people with vascular dementia are able to maintain their independence and quality of life for as long as possible.
Some common types of psychotic disorders include:
1. Schizophrenia: A chronic and severe mental disorder that affects how a person thinks, feels, and behaves. It can cause hallucinations, delusions, and disorganized thinking.
2. Bipolar Disorder: A mood disorder that causes extreme changes in mood, energy, and behavior. It can lead to manic or hypomanic episodes, as well as depression.
3. Schizoaffective Disorder: A mental disorder that combines symptoms of schizophrenia and a mood disorder. It can cause hallucinations, delusions, and mood swings.
4. Brief Psychotic Disorder: A short-term episode of psychosis that can be triggered by a stressful event. It can cause hallucinations, delusions, and a break from reality.
5. Postpartum Psychosis: A rare condition that occurs in some new mothers after childbirth. It can cause hallucinations, delusions, and a break from reality.
6. Drug-Induced Psychosis: A psychotic episode caused by taking certain medications or drugs. It can cause hallucinations, delusions, and a break from reality.
7. Alcohol-Related Psychosis: A psychotic episode caused by alcohol use disorder. It can cause hallucinations, delusions, and a break from reality.
8. Trauma-Related Psychosis: A psychotic episode caused by a traumatic event. It can cause hallucinations, delusions, and a break from reality.
9. Psychotic Disorder Not Otherwise Specified (NOS): A catch-all diagnosis for psychotic episodes that do not meet the criteria for any other specific psychotic disorder.
Symptoms of psychotic disorders can vary depending on the individual and the specific disorder. Common symptoms include:
1. Hallucinations: Seeing, hearing, or feeling things that are not there.
2. Delusions: False beliefs that are not based in reality.
3. Disorganized thinking and speech: Difficulty organizing thoughts and expressing them in a clear and logical manner.
4. Disorganized behavior: Incoherent or bizarre behavior, such as dressing inappropriately for the weather or neglecting personal hygiene.
5. Catatonia: A state of immobility or abnormal movement, such as rigidity or agitation.
6. Negative symptoms: A decrease in emotional expression or motivation, such as a flat affect or a lack of interest in activities.
7. Cognitive impairment: Difficulty with attention, memory, and other cognitive functions.
8. Social withdrawal: Avoidance of social interactions and relationships.
9. Lack of self-care: Neglecting personal hygiene, nutrition, and other basic needs.
10. Suicidal or homicidal ideation: Thoughts of harming oneself or others.
It's important to note that not everyone with schizophrenia will experience all of these symptoms, and some people may experience additional symptoms not listed here. Additionally, the severity and frequency of symptoms can vary widely from person to person. With proper treatment and support, many people with schizophrenia are able to manage their symptoms and lead fulfilling lives.
The Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) defines Autistic Disorder as a pervasive developmental disorder that meets the following criteria:
A. Persistent deficits in social communication and social interaction across multiple contexts, including:
1. Deficits in social-emotional reciprocity (e.g., abnormal or absent eye contact, impaired understanding of facial expressions, delayed or lack of response to social overtures).
2. Deficits in developing, maintaining, and understanding relationships (e.g., difficulty initiating or sustaining conversations, impairment in understanding social norms, rules, and expectations).
3. Deficits in using nonverbal behaviors to regulate social interaction (e.g., difficulty with eye contact, facial expressions, body language, gestures).
B. Restricted, repetitive patterns of behavior, interests, or activities, as manifested by at least one of the following:
1. Stereotyped or repetitive motor movements, use of objects, or speech (e.g., hand flapping, head banging, repeating words or phrases).
2. Insistence on sameness, inflexibility, and adherence to routines or rituals.
3. Preoccupation with specific interests or activities that are repeated in a rigid and restricted manner (e.g., preoccupation with a particular topic, excessive focus on a specific activity).
C. Symptoms must be present in the early developmental period and significantly impact social, occupational, or other areas of functioning.
D. The symptoms do not occur exclusively during a medical or neurological condition (e.g., intellectual disability, hearing loss).
It is important to note that Autistic Disorder is a spectrum disorder and individuals with this diagnosis may have varying degrees of severity in their symptoms. Additionally, there are several other Pervasive Developmental Disorders (PDDs) that have similar diagnostic criteria but may differ in severity and presentation. These include:
A. Asperger's Disorder: Characterized by difficulties with social interaction and communication, but without the presence of significant delay or retardation in language development.
B. Rett Syndrome: A rare genetic disorder that is characterized by difficulties with social interaction, communication, and repetitive behaviors.
C. Childhood Disintegrative Disorder: Characterized by a loss of language and social skills that occurs after a period of normal development.
It is important to consult with a qualified professional, such as a psychologist or psychiatrist, for an accurate diagnosis and appropriate treatment.
The word schizophrenia comes from Greek roots meaning "split mind." It was coined by Swiss psychiatrist Eugen Bleuler in 1911 to describe the splitting or fragmentation of thought processes, feelings, and sense of self that can occur in the disorder. The word is often used interchangeably with the term mental illness or mental disorder.
Schizophrenia is a chronic, severe, and debilitating mental illness characterized by symptoms such as delusions, hallucinations, disorganized thinking and behavior, and negative symptoms like a lack of motivation or emotional expression. The disorder affects about 1 percent of the population worldwide and is often accompanied by other conditions such as depression, anxiety disorders, and substance abuse.
The causes of schizophrenia are still not fully understood, but research suggests that it may involve a combination of genetic, environmental, and neurochemical factors. There is no cure for the disorder, but treatment with medications and various forms of therapy can help to manage symptoms and improve quality of life.
There are several types of atrophy that can occur in different parts of the body. For example:
1. Muscular atrophy: This occurs when muscles weaken and shrink due to disuse or injury.
2. Neuronal atrophy: This occurs when nerve cells degenerate, leading to a loss of cognitive function and memory.
3. Cardiac atrophy: This occurs when the heart muscle weakens and becomes less efficient, leading to decreased cardiac output.
4. Atrophic gastritis: This is a type of stomach inflammation that can lead to the wasting away of the stomach lining.
5. Atrophy of the testes: This occurs when the testes shrink due to a lack of use or disorder, leading to decreased fertility.
Atrophy can be diagnosed through various medical tests and imaging studies, such as MRI or CT scans. Treatment for atrophy depends on the underlying cause and may involve physical therapy, medication, or surgery. In some cases, atrophy can be prevented or reversed with proper treatment and care.
In summary, atrophy is a degenerative process that can occur in various parts of the body due to injury, disease, or disuse. It can lead to a loss of function and decreased quality of life, but with proper diagnosis and treatment, it may be possible to prevent or reverse some forms of atrophy.
There are several types of learning disorders, including:
1. Dyslexia: A learning disorder that affects an individual's ability to read and spell words. Individuals with dyslexia may have difficulty recognizing letters, sounds, or word patterns.
2. Dyscalculia: A learning disorder that affects an individual's ability to understand and perform mathematical calculations. Individuals with dyscalculia may have difficulty with numbers, quantities, or mathematical concepts.
3. Dysgraphia: A learning disorder that affects an individual's ability to write and spell words. Individuals with dysgraphia may have difficulty with hand-eye coordination, fine motor skills, or language processing.
4. Attention Deficit Hyperactivity Disorder (ADHD): A neurodevelopmental disorder that affects an individual's ability to focus, pay attention, and regulate their behavior. Individuals with ADHD may have difficulty with organization, time management, or following instructions.
5. Auditory Processing Disorder: A learning disorder that affects an individual's ability to process and understand auditory information. Individuals with auditory processing disorder may have difficulty with listening, comprehension, or speech skills.
6. Visual Processing Disorder: A learning disorder that affects an individual's ability to process and understand visual information. Individuals with visual processing disorder may have difficulty with reading, writing, or other tasks that require visual processing.
7. Executive Function Deficits: A learning disorder that affects an individual's ability to plan, organize, and execute tasks. Individuals with executive function deficits may have difficulty with time management, organization, or self-regulation.
Learning disorders can be diagnosed by a trained professional, such as a psychologist, neuropsychologist, or learning specialist, through a comprehensive assessment that includes cognitive and academic testing, as well as a review of the individual's medical and educational history. The specific tests and assessments used will depend on the suspected type of learning disorder and the individual's age and background.
There are several approaches to treating learning disorders, including:
1. Accommodations: Providing individuals with accommodations, such as extra time to complete assignments or the option to take a test orally, can help level the playing field and enable them to succeed academically.
2. Modifications: Making modifications to the curriculum or instructional methods can help individuals with learning disorders access the material and learn in a way that is tailored to their needs.
3. Therapy: Cognitive-behavioral therapy (CBT) and other forms of therapy can help individuals with learning disorders develop strategies for managing their challenges and improving their academic performance.
4. Assistive technology: Assistive technology, such as text-to-speech software or speech-to-text software, can help individuals with learning disorders access information and communicate more effectively.
5. Medication: In some cases, medication may be prescribed to help manage symptoms associated with learning disorders, such as attention deficit hyperactivity disorder (ADHD).
6. Multi-sensory instruction: Using multiple senses (such as sight, sound, and touch) to learn new information can be helpful for individuals with learning disorders.
7. Self-accommodations: Teaching individuals with learning disorders how to identify and use their own strengths and preferences to accommodate their challenges can be effective in helping them succeed academically.
8. Parental involvement: Encouraging parents to be involved in their child's education and providing them with information and resources can help them support their child's learning and development.
9. Collaboration: Collaborating with other educators, professionals, and family members to develop a comprehensive treatment plan can help ensure that the individual receives the support they need to succeed academically.
It is important to note that each individual with a learning disorder is unique and may respond differently to different treatments. A comprehensive assessment and ongoing monitoring by a qualified professional is necessary to determine the most effective treatment plan for each individual.
There are several types of mood disorders, including:
1. Major Depressive Disorder (MDD): This is a condition characterized by persistent feelings of sadness, hopelessness, and a loss of interest in activities that were once enjoyed. It can also involve changes in appetite, sleep patterns, and energy levels.
2. Bipolar Disorder: This is a condition that involves periods of mania or hypomania (elevated mood) alternating with episodes of depression.
3. Persistent Depressive Disorder (PDD): This is a condition characterized by persistent low mood, lasting for two years or more. It can also involve changes in appetite, sleep patterns, and energy levels.
4. Postpartum Depression (PPD): This is a condition that occurs in some women after childbirth, characterized by feelings of sadness, anxiety, and a lack of interest in activities.
5. Seasonal Affective Disorder (SAD): This is a condition that occurs during the winter months, when there is less sunlight. It is characterized by feelings of sadness, lethargy, and a lack of energy.
6. Anxious Distress: This is a condition characterized by excessive worry, fear, and anxiety that interferes with daily life.
7. Adjustment Disorder: This is a condition that occurs when an individual experiences a significant change or stressor in their life, such as the loss of a loved one or a job change. It is characterized by feelings of sadness, anxiety, and a lack of interest in activities.
8. Premenstrual Dysphoric Disorder (PMDD): This is a condition that occurs in some women during the premenstrual phase of their menstrual cycle, characterized by feelings of sadness, anxiety, and a lack of energy.
Mood disorders can be treated with a combination of medication and therapy. Antidepressant medications, such as selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs), are commonly used to treat mood disorders. These medications can help relieve symptoms of depression and anxiety by altering the levels of neurotransmitters in the brain.
Therapy, such as cognitive-behavioral therapy (CBT) and interpersonal therapy (IPT), can also be effective in treating mood disorders. CBT helps individuals identify and change negative thought patterns and behaviors that contribute to their depression, while IPT focuses on improving communication skills and relationships with others.
In addition to medication and therapy, lifestyle changes such as regular exercise, healthy eating, and getting enough sleep can also be helpful in managing mood disorders. Support from family and friends, as well as self-care activities such as meditation and relaxation techniques, can also be beneficial.
It is important to seek professional help if symptoms of depression or anxiety persist or worsen over time. With appropriate treatment, individuals with mood disorders can experience significant improvement in their symptoms and overall quality of life.
Parkinson's disease is the second most common neurodegenerative disorder after Alzheimer's disease, affecting approximately 1% of the population over the age of 60. It is more common in men than women and has a higher incidence in Caucasians than in other ethnic groups.
The primary symptoms of Parkinson's disease are:
* Tremors or trembling, typically starting on one side of the body
* Rigidity or stiffness, causing difficulty with movement
* Bradykinesia or slowness of movement, including a decrease in spontaneous movements such as blinking or smiling
* Postural instability, leading to falls or difficulty with balance
As the disease progresses, symptoms can include:
* Difficulty with walking, gait changes, and freezing episodes
* Dry mouth, constipation, and other non-motor symptoms
* Cognitive changes, such as dementia, memory loss, and confusion
* Sleep disturbances, including REM sleep behavior disorder
* Depression, anxiety, and other psychiatric symptoms
The exact cause of Parkinson's disease is not known, but it is believed to involve a combination of genetic and environmental factors. The disease is associated with the degradation of dopamine-producing neurons in the substantia nigra, leading to a deficiency of dopamine in the brain. This deficiency disrupts the normal functioning of the basal ganglia, a group of structures involved in movement control, leading to the characteristic symptoms of the disease.
There is no cure for Parkinson's disease, but various treatments are available to manage its symptoms. These include:
* Medications such as dopaminergic agents (e.g., levodopa) and dopamine agonists to replace lost dopamine and improve motor function
* Deep brain stimulation, a surgical procedure that involves implanting an electrode in the brain to deliver electrical impulses to specific areas of the brain
* Physical therapy to improve mobility and balance
* Speech therapy to improve communication and swallowing difficulties
* Occupational therapy to improve daily functioning
It is important for individuals with Parkinson's disease to work closely with their healthcare team to develop a personalized treatment plan that addresses their specific needs and improves their quality of life. With appropriate treatment and support, many people with Parkinson's disease are able to manage their symptoms and maintain a good level of independence for several years after diagnosis.
1) They share similarities with humans: Many animal species share similar biological and physiological characteristics with humans, making them useful for studying human diseases. For example, mice and rats are often used to study diseases such as diabetes, heart disease, and cancer because they have similar metabolic and cardiovascular systems to humans.
2) They can be genetically manipulated: Animal disease models can be genetically engineered to develop specific diseases or to model human genetic disorders. This allows researchers to study the progression of the disease and test potential treatments in a controlled environment.
3) They can be used to test drugs and therapies: Before new drugs or therapies are tested in humans, they are often first tested in animal models of disease. This allows researchers to assess the safety and efficacy of the treatment before moving on to human clinical trials.
4) They can provide insights into disease mechanisms: Studying disease models in animals can provide valuable insights into the underlying mechanisms of a particular disease. This information can then be used to develop new treatments or improve existing ones.
5) Reduces the need for human testing: Using animal disease models reduces the need for human testing, which can be time-consuming, expensive, and ethically challenging. However, it is important to note that animal models are not perfect substitutes for human subjects, and results obtained from animal studies may not always translate to humans.
6) They can be used to study infectious diseases: Animal disease models can be used to study infectious diseases such as HIV, TB, and malaria. These models allow researchers to understand how the disease is transmitted, how it progresses, and how it responds to treatment.
7) They can be used to study complex diseases: Animal disease models can be used to study complex diseases such as cancer, diabetes, and heart disease. These models allow researchers to understand the underlying mechanisms of the disease and test potential treatments.
8) They are cost-effective: Animal disease models are often less expensive than human clinical trials, making them a cost-effective way to conduct research.
9) They can be used to study drug delivery: Animal disease models can be used to study drug delivery and pharmacokinetics, which is important for developing new drugs and drug delivery systems.
10) They can be used to study aging: Animal disease models can be used to study the aging process and age-related diseases such as Alzheimer's and Parkinson's. This allows researchers to understand how aging contributes to disease and develop potential treatments.
The following are some common types of motor skill disorders:
1. Dyspraxia: This is a developmental condition that affects the ability to plan and perform movements. Individuals with dyspraxia may have difficulty with coordination, balance, and spatial awareness.
2. Apraxia: This is a neurological disorder that affects an individual's ability to perform voluntary movements despite having the physical strength and coordination to do so.
3. Ataxia: This is a condition that affects an individual's balance, coordination, and ability to perform purposeful movements. It can be caused by injury or disease to the cerebellum or other parts of the brain.
4. Parkinson's disease: This is a neurodegenerative disorder that affects movement, including fine motor skills such as writing and gross motor skills such as walking and balance.
5. Cerebral palsy: This is a developmental condition that can affect an individual's ability to move and control their body. It can impact both fine and gross motor skills.
6. Stroke: A stroke occurs when the blood supply to the brain is interrupted, leading to damage to the brain tissue. This can result in difficulty with movement, including fine and gross motor skills.
7. Traumatic brain injury: This occurs when the brain is injured as a result of a blow or jolt to the head. It can lead to difficulties with movement, memory, and other cognitive functions.
8. Spinal cord injury: This occurs when the spinal cord is damaged, either from trauma or disease. It can result in loss of movement and sensation below the level of the injury.
9. Multiple sclerosis: This is a chronic autoimmune disease that affects the central nervous system, including the brain and spinal cord. It can cause difficulties with movement, balance, and coordination.
10. Spina bifida: This is a congenital condition in which the spine does not properly close during fetal development. It can result in a range of physical and cognitive disabilities, including difficulty with movement and coordination.
It's important to note that these conditions can have varying levels of severity and impact on an individual's ability to move and control their body. Additionally, there are many other conditions and diseases that can affect the nervous system and result in difficulties with movement.
Types of Language Disorders:
1. Developmental Language Disorder (DLD): This is a condition where children have difficulty learning language skills, such as grammar, vocabulary, and sentence structure, despite being exposed to language in their environment. DLD can be diagnosed in children between the ages of 2 and 5.
2. Acquired Language Disorder: This is a condition that occurs when an individual experiences brain damage or injury that affects their ability to understand and produce language. Acquired language disorders can be caused by stroke, traumatic brain injury, or other neurological conditions.
3. Aphasia: This is a condition that occurs when an individual experiences damage to the language areas of their brain, typically as a result of stroke or traumatic brain injury. Aphasia can affect an individual's ability to understand, speak, read, and write language.
4. Dysarthria: This is a condition that affects an individual's ability to produce speech sounds due to weakness, paralysis, or incoordination of the muscles used for speaking. Dysarthria can be caused by stroke, cerebral palsy, or other neurological conditions.
5. Apraxia: This is a condition that affects an individual's ability to coordinate the movements of their lips, tongue, and jaw to produce speech sounds. Apraxia can be caused by stroke, head injury, or other neurological conditions.
Causes and Risk Factors:
1. Genetic factors: Some language disorders may be inherited from parents or grandparents.
2. Brain damage or injury: Stroke, traumatic brain injury, or other neurological conditions can cause acquired language disorders.
3. Developmental delays: Children with developmental delays or disorders, such as autism or Down syndrome, may experience language disorders.
4. Hearing loss or impairment: Children who have difficulty hearing may experience language delays or disorders.
5. Environmental factors: Poverty, poor nutrition, and limited access to educational resources can contribute to language disorders in children.
Signs and Symptoms:
1. Difficulty articulating words or sentences
2. Slurred or distorted speech
3. Limited vocabulary or grammar skills
4. Difficulty understanding spoken language
5. Avoidance of speaking or social interactions
6. Behavioral difficulties, such as aggression or frustration
7. Delayed language development in children
8. Difficulty with reading and writing skills
Treatment and Interventions:
1. Speech therapy: A speech-language pathologist (SLP) can work with individuals to improve their language skills through exercises, activities, and strategies.
2. Cognitive training: Individuals with language disorders may benefit from cognitive training programs that target attention, memory, and other cognitive skills.
3. Augmentative and alternative communication (AAC) devices: These devices can help individuals with severe language disorders communicate more effectively.
4. Behavioral interventions: Behavioral therapy can help individuals with language disorders manage their behavior and improve their social interactions.
5. Family support: Family members can provide support and encouragement to individuals with language disorders, which can help improve outcomes.
6. Educational accommodations: Individuals with language disorders may be eligible for educational accommodations, such as extra time to complete assignments or the use of a tape recorder during lectures.
7. Medication: In some cases, medication may be prescribed to help manage symptoms of language disorders, such as anxiety or depression.
Prognosis and Quality of Life:
The prognosis for individuals with language disorders varies depending on the severity of their condition and the effectiveness of their treatment. With appropriate support and intervention, many individuals with language disorders are able to improve their language skills and lead fulfilling lives. However, some individuals may experience ongoing challenges with communication and social interaction, which can impact their quality of life.
In conclusion, language disorders can have a significant impact on an individual's ability to communicate and interact with others. While there is no cure for language disorders, there are many effective treatments and interventions that can help improve outcomes. With appropriate support and accommodations, individuals with language disorders can lead fulfilling lives and achieve their goals.
Developmental disabilities can include a wide range of diagnoses, such as:
1. Autism Spectrum Disorder (ASD): A neurological disorder characterized by difficulties with social interaction, communication, and repetitive behaviors.
2. Intellectual Disability (ID): A condition in which an individual's cognitive abilities are below average, affecting their ability to learn, reason, and communicate.
3. Down Syndrome: A genetic disorder caused by an extra copy of chromosome 21, characterized by intellectual disability, delayed speech and language development, and a distinctive physical appearance.
4. Cerebral Palsy (CP): A group of disorders that affect movement, balance, and posture, often resulting from brain injury or abnormal development during fetal development or early childhood.
5. Attention Deficit Hyperactivity Disorder (ADHD): A neurodevelopmental disorder characterized by symptoms of inattention, hyperactivity, and impulsivity.
6. Learning Disabilities: Conditions that affect an individual's ability to learn and process information, such as dyslexia, dyscalculia, and dysgraphia.
7. Traumatic Brain Injury (TBI): An injury to the brain caused by a blow or jolt to the head, often resulting in cognitive, emotional, and physical impairments.
8. Severe Hearing or Vision Loss: A condition in which an individual experiences significant loss of hearing or vision, affecting their ability to communicate and interact with their environment.
9. Multiple Disabilities: A condition in which an individual experiences two or more developmental disabilities simultaneously, such as intellectual disability and autism spectrum disorder.
10. Undiagnosed Developmental Delay (UDD): A condition in which an individual experiences delays in one or more areas of development, but does not meet the diagnostic criteria for a specific developmental disability.
These conditions can have a profound impact on an individual's quality of life, and it is important to provide appropriate support and accommodations to help them reach their full potential.
The term "amyloid" refers specifically to the type of protein aggregate that forms these plaques, and is derived from the Greek word for "flour-like." Amyloidosis is the general term used to describe the condition of having amyloid deposits in the body, while Alzheimer's disease is a specific type of amyloidosis that is characterized by the accumulation of beta-amyloid peptides in the brain.
Plaques, amyloid play a central role in the pathogenesis of many neurodegenerative diseases, and understanding their formation and clearance is an area of ongoing research. In addition to their role in Alzheimer's disease, amyloid plaques have been implicated in other conditions such as cerebral amyloid angiopathy, primary lateral sclerosis, and progressive supranuclear palsy.
Plaques, amyloid are composed of a variety of proteins, including beta-amyloid peptides, tau protein, and apolipoprotein E (apoE). The composition and structure of these plaques can vary depending on the underlying disease, and their presence is often associated with inflammation and oxidative stress.
In addition to their role in neurodegeneration, amyloid plaques have been implicated in other diseases such as type 2 diabetes and cardiovascular disease. The accumulation of amyloid fibrils in these tissues can contribute to the development of insulin resistance and atherosclerosis, respectively.
Overall, plaques, amyloid are a complex and multifaceted area of research, with many open questions remaining about their formation, function, and clinical implications. Ongoing studies in this field may provide valuable insights into the pathogenesis of various diseases and ultimately lead to the development of novel therapeutic strategies for these conditions.
In conclusion, plaques, amyloid are a hallmark of several neurodegenerative diseases, including Alzheimer's disease, and have been associated with inflammation, oxidative stress, and neurodegeneration. The composition and structure of these plaques can vary depending on the underlying disease, and their presence is often linked to the progression of the condition. Furthermore, amyloid plaques have been implicated in other diseases such as type 2 diabetes and cardiovascular disease, highlighting their potential clinical significance beyond neurodegeneration. Ongoing research into the mechanisms of amyloid plaque formation and clearance may lead to the development of novel therapeutic strategies for these conditions.
The exact cause of depressive disorder is not fully understood, but it is believed to involve a combination of genetic, environmental, and psychological factors. Some common risk factors for developing depressive disorder include:
* Family history of depression
* Traumatic events, such as abuse or loss
* Chronic stress
* Substance abuse
* Chronic illness or chronic pain
There are several different types of depressive disorders, including:
* Major depressive disorder (MDD): This is the most common type of depression, characterized by one or more major depressive episodes in a person's lifetime.
* Persistent depressive disorder (PDD): This type of depression is characterized by persistent, low-grade symptoms that last for two years or more.
* Bipolar disorder: This is a mood disorder that involves periods of both depression and mania or hypomania.
* Postpartum depression (PPD): This is a type of depression that occurs in women after childbirth.
* Severe depression: This is a severe and debilitating form of depression that can interfere with daily life and relationships.
Treatment for depressive disorder typically involves a combination of medication and therapy, such as antidepressant medications and cognitive-behavioral therapy (CBT). Other forms of therapy, such as psychodynamic therapy or interpersonal therapy, may also be effective. Lifestyle changes, such as regular exercise, healthy eating, and getting enough sleep, can also help manage symptoms.
It's important to seek professional help if you or someone you know is experiencing symptoms of depressive disorder. With proper treatment, many people are able to recover from depression and lead fulfilling lives.
Prodromal symptoms are like the sentinels of health, signaling that something is amiss before the full-blown disease or condition has manifested. By recognizing and addressing these early signs, individuals may be able to prevent or slow the progression of the underlying condition. However, it's important to note that not all prodromal symptoms will necessarily lead to a specific diagnosis, and proper medical evaluation is necessary for an accurate diagnosis and appropriate treatment.
Some common examples of prodromal symptoms include:
1. Fatigue: Feeling unusually tired or exhausted, which may be an early sign of an underlying chronic condition like fibromyalgia or chronic fatigue syndrome.
2. Muscle aches and pains: Experiencing joint or muscle pain that won't go away, which could be a sign of an autoimmune disorder like rheumatoid arthritis or lupus.
3. Digestive issues: Bloating, abdominal pain, or changes in bowel movements, which may indicate an underlying gastrointestinal condition like irritable bowel syndrome (IBS) or inflammatory bowel disease (IBD).
4. Skin changes: Noticing unusual skin rashes, lesions, or discoloration, which could be an early sign of a condition like psoriasis, eczema, or melanoma.
5. Sleep disturbances: Difficulty falling or staying asleep, or experiencing vivid dreams or nightmares, which may indicate an underlying sleep disorder like insomnia or narcolepsy.
6. Mood changes: Feeling anxious, depressed, or having mood swings, which could be an early sign of a mental health condition like bipolar disorder or major depressive disorder.
7. Cognitive impairment: Difficulty concentrating, forgetfulness, or confusion, which may indicate an underlying neurological condition like Alzheimer's disease or Parkinson's disease.
8. Eye problems: Blurred vision, double vision, or seeing flashes of light, which could be an early sign of an eye condition like cataracts, glaucoma, or age-related macular degeneration.
9. Weight changes: Unexplained weight gain or loss, which may indicate an underlying hormonal imbalance, metabolic disorder, or other health issue.
10. Hearing problems: Difficulty hearing, ringing in the ears (tinnitus), or ear pain, which could be an early sign of an ear condition like otosclerosis or Meniere's disease.
If you are experiencing any of these symptoms, it is essential to consult with a healthcare professional for proper evaluation and diagnosis. Early detection and treatment can help manage symptoms and prevent long-term health complications.
Some common types of perceptual disorders include:
1. Visual perceptual disorders: These disorders affect an individual's ability to interpret and make sense of visual information from the environment. They can result in difficulties with recognizing objects, perceiving depth and distance, and tracking movement.
2. Auditory perceptual disorders: These disorders affect an individual's ability to interpret and make sense of sound. They can result in difficulties with hearing and understanding speech, as well as distinguishing between different sounds.
3. Tactile perceptual disorders: These disorders affect an individual's ability to interpret and make sense of touch. They can result in difficulties with recognizing objects through touch, as well as interpreting tactile sensations such as pain, temperature, and texture.
4. Olfactory perceptual disorders: These disorders affect an individual's ability to interpret and make sense of smells. They can result in difficulties with identifying different odors and distinguishing between them.
5. Gustatory perceptual disorders: These disorders affect an individual's ability to interpret and make sense of tastes. They can result in difficulties with identifying different flavors and distinguishing between them.
6. Balance and equilibrium disorders: These disorders affect an individual's ability to maintain balance and equilibrium. They can result in difficulties with standing, walking, and maintaining posture.
Perceptual disorders can have a significant impact on an individual's daily life, making it difficult to perform everyday tasks and activities. Treatment for perceptual disorders often involves a combination of sensory therapy, behavioral therapy, and assistive technologies. The goal of treatment is to help the individual compensate for any impairments in sensory processing and improve their ability to function in daily life.
Disease progression can be classified into several types based on the pattern of worsening:
1. Chronic progressive disease: In this type, the disease worsens steadily over time, with a gradual increase in symptoms and decline in function. Examples include rheumatoid arthritis, osteoarthritis, and Parkinson's disease.
2. Acute progressive disease: This type of disease worsens rapidly over a short period, often followed by periods of stability. Examples include sepsis, acute myocardial infarction (heart attack), and stroke.
3. Cyclical disease: In this type, the disease follows a cycle of worsening and improvement, with periodic exacerbations and remissions. Examples include multiple sclerosis, lupus, and rheumatoid arthritis.
4. Recurrent disease: This type is characterized by episodes of worsening followed by periods of recovery. Examples include migraine headaches, asthma, and appendicitis.
5. Catastrophic disease: In this type, the disease progresses rapidly and unpredictably, with a poor prognosis. Examples include cancer, AIDS, and organ failure.
Disease progression can be influenced by various factors, including:
1. Genetics: Some diseases are inherited and may have a predetermined course of progression.
2. Lifestyle: Factors such as smoking, lack of exercise, and poor diet can contribute to disease progression.
3. Environmental factors: Exposure to toxins, allergens, and other environmental stressors can influence disease progression.
4. Medical treatment: The effectiveness of medical treatment can impact disease progression, either by slowing or halting the disease process or by causing unintended side effects.
5. Co-morbidities: The presence of multiple diseases or conditions can interact and affect each other's progression.
Understanding the type and factors influencing disease progression is essential for developing effective treatment plans and improving patient outcomes.
The symptoms of Lewy body disease can vary from person to person, but they often include:
1. Cognitive problems, such as difficulty with memory, attention, and decision-making.
2. Slowness of movement, rigidity, and tremors, similar to those seen in Parkinson's disease.
3. Visual hallucinations and sleep disturbances.
4. Balance problems and falls.
5. Mood changes, such as depression and anxiety.
Lewy body disease can be difficult to diagnose, as it can resemble other conditions such as Alzheimer's disease or Parkinson's disease. A definitive diagnosis is usually made through an autopsy after death, but a clinical diagnosis can be made based on a combination of symptoms and medical imaging studies.
There is no cure for Lewy body disease, but medications and therapies can help manage its symptoms. Treatment options may include cholinesterase inhibitors, dopamine agonists, and antidepressants, as well as physical, occupational, and speech therapy. In some cases, surgery may be recommended to regulate medication or improve cognitive function.
Lewy body disease is a relatively rare condition, affecting about 1% of people over the age of 65. It is more common in men than women, and the risk of developing the disease increases with age. There is currently no known cause for Lewy body disease, but research suggests that it may be linked to genetic factors and exposure to certain environmental toxins.
In summary, Lewy body disease is a progressive neurodegenerative disorder that affects the brain and nervous system, characterized by abnormal protein deposits called Lewy bodies. It can cause a range of cognitive and motor symptoms, and diagnosis can be challenging. There is no cure for the disease, but medications and therapies can help manage its symptoms.
The term "small vessel disease" encompasses a range of conditions that affect the small blood vessels in the brain, including:
1. Cerebral amyloid angiopathy (CAA): A condition characterized by the accumulation of beta-amyloid peptides in the walls of small blood vessels, leading to vascular inflammation and degeneration.
2. Cerebral infarction (CI): A condition caused by a blockage or rupture of small blood vessels in the brain, resulting in tissue damage or death due to lack of oxygen and nutrients.
3. Leukoaraiosis: A condition characterized by the degeneration of white matter in the brain, leading to a loss of myelin and axonal damage.
4. Moyamoya disease (MMD): A rare condition caused by stenosis or occlusion of the internal carotid artery and its branches, leading to decreased blood flow to the brain.
5. Small vessel ischemic change (SVIC): A condition characterized by the degeneration of small blood vessels in the brain due to chronic hypoperfusion or other factors.
6. Vasculitis: An inflammatory condition affecting the blood vessels in the brain, leading to damage and scarring.
7. Other conditions such as hypertension, diabetes, and hyperlipidemia can also contribute to the development of CSVD.
The exact pathophysiology of CSVD is complex and involves multiple factors, including genetic predisposition, aging, inflammation, oxidative stress, and vascular damage. The symptoms of CSVD can vary depending on the location and severity of the affected blood vessels, but may include cognitive decline, memory loss, difficulty with speech and language, weakness or numbness in the limbs, and vision problems.
CSVD is often difficult to diagnose, as its symptoms can be similar to other conditions such as Alzheimer's disease or stroke. A comprehensive diagnostic workup may include a physical examination, medical history, neuroimaging studies (such as CT or MRI scans), and laboratory tests to rule out other conditions.
There is currently no cure for CSVD, but various treatment options are available to manage its symptoms and slow its progression. These may include medications to control hypertension, diabetes, and hyperlipidemia; lifestyle modifications such as regular exercise and a healthy diet; and rehabilitation therapies to improve cognitive and motor function. In severe cases, surgical interventions such as bypass surgery or endarterectomy may be necessary.
In conclusion, CSVD is a complex and multifactorial condition that affects the blood vessels in the brain, leading to a range of cognitive and motor symptoms. While there is currently no cure for CSVD, various treatment options are available to manage its symptoms and slow its progression. Early detection and management of underlying risk factors can help to slow the progression of CSVD and improve outcomes for affected individuals.
There are several subtypes of FTD, each with distinct clinical features and rates of progression. The most common subtypes include:
1. Behavioral variant FTD (bvFTD): This subtype is characterized by changes in personality, behavior, and social conduct, such as a lack of empathy, impulsivity, and aggression.
2. Language variant FTD (lvFTD): This subtype is characterized by progressive language decline, including difficulty with word-finding, syntax, and comprehension.
3. Primary progressive agrammatic alexia (PPA): This subtype is characterized by progressive loss of language abilities, including grammar and word retrieval.
4. Progressive supranuclear palsy (PSP): This subtype is characterized by slow movement, rigidity, and dementia, with a higher risk of developing parkinsonism.
The exact cause of FTD is not yet fully understood, but it is believed to be linked to abnormal protein accumulation in the brain, including tau and TDP-43 proteins. There is currently no cure for FTD, but various medications and therapies can help manage its symptoms and slow its progression.
FTD can be challenging to diagnose, as it can resemble other conditions such as Alzheimer's disease or frontal lobe lesions. A definitive diagnosis is typically made through a combination of clinical evaluation, neuroimaging, and pathological analysis of brain tissue after death.
FTD has a significant impact on patients and their families, affecting not only cognitive function but also behavior, mood, and social relationships. It can also place a significant burden on caregivers, who may need to provide around-the-clock support and assistance.
Overall, FTD is a complex and heterogeneous disorder that requires further research to better understand its causes, improve diagnostic accuracy, and develop effective treatments.
There are different types of amnesia, including:
1. Retrograde amnesia: loss of memory of events that occurred before the onset of amnesia.
2. Anterograde amnesia: inability to form new memories after the onset of amnesia.
3. Transient global amnesia: temporary and reversible loss of memory due to a specific cause, such as a stroke or a head injury.
4. Korsakoff's syndrome: a condition caused by alcoholism and malnutrition that affects the hippocampus and the ability to form new memories.
5. Dissociative amnesia: loss of memory due to psychological trauma or stress, often accompanied by dissociation from reality.
The symptoms of amnesia can vary depending on the underlying cause and the severity of the condition. Some common symptoms include:
1. Difficulty learning new information
2. Forgetting recent events or conversations
3. Inability to recall past events or experiences
4. Confusion and disorientation
5. Difficulty with problem-solving and decision-making
The diagnosis of amnesia is based on a combination of medical history, physical examination, and neuropsychological tests. Imaging studies such as CT or MRI scans may also be used to rule out other causes of memory loss.
Treatment for amnesia depends on the underlying cause and may include:
1. Medications to manage symptoms such as anxiety, depression, or cognitive impairment.
2. Cognitive rehabilitation therapy to improve memory and problem-solving skills.
3. Behavioral interventions to help the individual adapt to their condition.
4. In some cases, surgery may be necessary to treat the underlying cause of amnesia, such as a tumor or a blood clot.
Overall, amnesia can have a significant impact on an individual's quality of life, but with proper diagnosis and treatment, many people are able to manage their symptoms and lead fulfilling lives.
Cognition
Spatial cognition
Numerical cognition
Augmented cognition
Steering cognition
Embodied cognition
Insect cognition
Epistemic cognition
Cultural cognition
Implicit cognition
Elephant cognition
Animal cognition
Comparative cognition
Situated cognition
Memory & Cognition
Social cognition
Plant cognition
Distributed cognition
Disjunctive cognition
Primate cognition
Cognition (journal)
Group cognition
Computational cognition
Enclothed cognition
Unconscious cognition
Quantum cognition
Motor cognition
Perseverative cognition
Political cognition
NIMH » Cognition
Improving Cognition in Schizophrenia
Decoding Canine Cognition | National Eye Institute
Cognition-Boosting 'Smart Drugs' Not So Smart for Healthy People
NIH Guide: SOCIAL COGNITION AND AGING
Computational Modeling Sheds Light on Human Cognition and the Origins of Brain Disorders
The Effects of Estrogen Therapy on Cognition | National Institutes of Health (NIH)
Grant Abstract: Renal Transplantation, Homocysteine Lowering & Cognition
Mediterranean Diet, Weight Loss, and Cognition in Obese Older Adults
Alzheimer's gene protects cognition in Brazilian slums - Fogarty International Center @ NIH
Polychlorinated Biphenyl Exposures and Cognition in Older U.S. Adults: NHANES (1999-2002)
Role of Sleep Apnea in Cognition and Alzheimer's Disease Biomarkers in WTC Responders - WTC Health Program Research Gateway
Preventing Chronic Disease | Effect of Aerobic Exercise on Cognition, Academic Achievement, and Psychosocial Function in...
Cognition in CADASIL - PubMed
Fast Five Quiz: Depression and Cognition
NIH VideoCast - Neuron-glial interactions health and disease: from cognition to cancer
A mechanistic model of connector hubs, modularity and cognition - PubMed
Entry-level research assistant position(cognition in Parkinson's Disease) available in San Diego
Creator: Indiana University. Center for Research on Concepts and Cognition - Maxine Singer - Profiles in Science Search Results
NIMH » Laboratory of Brain and Cognition (LBC)
Neural correlates of abstract social cognition in Williams syndrome and 7q11.23 Duplication syndrome | NIH Research Festival
Health and Cognition among Adults with and without Traumatic Brain Injury: A Matched Case-Control Study
BOLD Connectivity Dynamics & Relationship to On-Going Cognition | Section on Functional Imaging Methods
cognition
More Evidence Flavonols Preserve Memory, Cognition
Computation and cognition
HANDLS Cognition publications
Geriatric Rehabilitation: Overview, Auditory and Visual Impairments, Falls
Behavior3
- In addition to its effects on sensory processing and waking behavior, norepinephrine is now recognized as a contributor to various aspects of cognition, including attention, behavioral flexibility, working memory, and long-term mnemonic processes. (hindawi.com)
- In this review, we will summarize the role and actions of NE in PFC and hippocampus and how it contributes to behavior and cognition. (hindawi.com)
- Certain thinking styles promote criminal behavior, and these criminogenic cognitions are not engaged in equally by all offenders. (ojp.gov)
Improves1
- Although it can cause word-finding difficulties, lamotrigine improves multiple areas of cognition, according to large open-label studies and a post-hoc analysis of controlled trials. (psychiatrictimes.com)
Deficits1
- Furthermore, we will consider how both the LC proper and forebrain noradrenergic transmission are known to change in some disease states characterized by disordered cognition and how behavioral deficits in a multitude of neuropsychiatric and neurodegenerative diseases might allude to dysfunction of the noradrenergic system (Table 1 ). (hindawi.com)
Search1
- Results of search for 'su:{Cognition. (who.int)
Health4
- In the current investigation, the researchers sought to identify offenders most likely to engage in criminogenic cognitions on the basis of status variables (i.e., demographic, incarceration, and mental health variables) using data from 595 adult male incarcerated offenders. (ojp.gov)
- Findings indicate that younger offenders, less educated offenders, Black and Hispanic offenders, single (i.e., not in a relationship) offenders, offenders without a violent index offense, offenders with a psychological disorder, and offenders not participating in mental health services all endorsed higher levels of some types of criminogenic cognitions. (ojp.gov)
- Although the effects of aerobic physical activity (APA) on children's physical health is well characterized, the effect of aerobic physical activity on cognition, academic achievement, and psychosocial function has not yet been established. (cdc.gov)
- There was no documentation of APA having any negative impact on children's cognition and psychosocial health, even in cases where school curriculum time was reassigned from classroom teaching to aerobic physical activity. (cdc.gov)
Human7
- A pilot human clinical trial conducted by researchers at Baylor College of Medicine reveals that supplementation with GlyNAC - a combination of glycine and N-acetylcysteine as precursors of the natural antioxidant glutathione - could improve many age-associated defects in older humans to improve muscle strength and cognition, and promote healthy aging. (bcm.edu)
- Animal and small-scale human studies have suggested that reduced microbial diversity is associated with poorer cognition, but studies have not been conducted in community-based large and diverse populations. (medscape.com)
- Members of the Social Cognition Research Group use primarily experimental behavioural and neuroimaging methods to investigate how cognition interacts with social factors in order to shape human judgment and behaviour, both in interpersonal and intergroup contexts. (uea.ac.uk)
- Programs: Human Factors/Applied Cognition. (gmu.edu)
- This concentration emphasizes the study of a combination of elements within human factors, applied cognition and neuroergonomics in its academic focus. (gmu.edu)
- Applied cognition is the study of the characteristics of basic human perception and cognitive processes relevant to the human performance at work. (gmu.edu)
- Human stress and cognition : an information processing approach / edited by Vernon Hamilton and David M. Warburton. (who.int)
Attention1
- The clinical hallmarks of delirium are decreased attention or awareness and a change in baseline cognition. (medscape.com)
Areas1
- However, more recent studies are beginning to show that people who have experienced childhood adversity may also have unique strengths and enhanced cognition in some areas. (madinamerica.com)
Studies2
- A large body of research supports a role for each of these in cognition and mood, though specific studies in bipolar disorder are scarce. (psychiatrictimes.com)
- All studies showed that APA had a generally positive impact on children's cognition and psychosocial function. (cdc.gov)
Support1
- Houve diferença estatisticamente support(p=0.045), and cognition(p=0.026) dimensions. (bvsalud.org)
Brain1
- Cognitive testing checks for problems with certain brain functions called "cognition. (medlineplus.gov)
Problems2
- Problems with cognition are called "cognitive impairment. (medlineplus.gov)
- disorder that causes uncontrolled movements, emotional problems, and loss of thinking ability (cognition). (medlineplus.gov)
Function1
- This systematic review provides an overview of research elucidating the relationship between aerobic physical activity and children's cognition, academic achievement, and psychosocial function. (cdc.gov)
Mental1
- Proceso de reforma en salud mental. (bvsalud.org)
Children's cognition3
- This systematic review provides an overview of research elucidating the relationship between aerobic physical activity and children's cognition, academic achievement, and psychosocial function. (cdc.gov)
- All studies showed that APA had a generally positive impact on children's cognition and psychosocial function. (cdc.gov)
- There was no documentation of APA having any negative impact on children's cognition and psychosocial health, even in cases where school curriculum time was reassigned from classroom teaching to aerobic physical activity. (cdc.gov)
Social cognition3
- Full Text PA-97-065 SOCIAL COGNITION AND AGING NIH GUIDE, Volume 26, Number 19, June 6, 1997 PA NUMBER: PA-97-065 P.T. 34 Keywords: Aging/Gerontology Cognitive Development/Process National Institute on Aging PURPOSE The National Institute on Aging (NIA) invites qualified researchers to submit research and training grant applications on social cognition and aging. (nih.gov)
- This announcement is coordinated with the National Institute of Mental Health (NIMH), which supports a range of topics in social cognition, and with the National Institute of Child Health and Human Development (NICHD), which supports applications about the normative cognitive, social, motivational and affective development of children from infancy through adolescence. (nih.gov)
- In this study, we used fMRI to study abstract social cognition in children with WS and DUP7, as well as typically developing (TD) children. (nih.gov)
NIMH1
- The Laboratory of Brain and Cognition (LBC) is a branch of the Division of Intramural Research Programs ( IRP ) at the National Institute of Mental Health ( NIMH ). (nih.gov)
Medscape1
- Fast Five Quiz: Depression and Cognition - Medscape - Dec 31, 2019. (medscape.com)
Advances1
- This article highlights some of the advances on cognition in CADASIL. (nih.gov)
Cognitive performance1
- VIENNA, Austria - Prescription drugs designed to boost cognition in neurodevelopmental disorders do not increase overall cognitive performance in healthy individuals - and may even reduce productivity, new research suggests. (medscape.com)
Symptoms1
- MDD involves symptoms (which can be recurring) of both affect and cognition. (medscape.com)
Health2
- Researchers from the National Institutes of Health (NIH) used computational modeling to uncover mutations in the human genome that likely influenced the evolution of human cognition. (nih.gov)
- Although the effects of aerobic physical activity (APA) on children's physical health is well characterized, the effect of aerobic physical activity on cognition, academic achievement, and psychosocial function has not yet been established. (cdc.gov)
Test1
- We have found a very high prevalence of OSA in the World Trade Center responder population, and the present work will evaluate the impact of OSA on early markers of Alzheimer 's Disease using plasma biomarkers, PET/MR and cognition using a visual-spatial memory test. (cdc.gov)