Cofilin 1
Actin Depolymerizing Factors
Cofilin 2
Lim Kinases
Destrin
Microfilament Proteins
Actins
Filamentous proteins that are the main constituent of the thin filaments of muscle fibers. The filaments (known also as filamentous or F-actin) can be dissociated into their globular subunits; each subunit is composed of a single polypeptide 375 amino acids long. This is known as globular or G-actin. In conjunction with MYOSINS, actin is responsible for the contraction and relaxation of muscle.
Actin Cytoskeleton
Pseudopodia
Phosphorylation
Profilins
Gelsolin
p21-Activated Kinases
Cell Surface Extensions
Actin-Related Protein 2-3 Complex
Phalloidine
Cytoskeleton
Ethenoadenosine Triphosphate
rho-Associated Kinases
A group of intracellular-signaling serine threonine kinases that bind to RHO GTP-BINDING PROTEINS. They were originally found to mediate the effects of rhoA GTP-BINDING PROTEIN on the formation of STRESS FIBERS and FOCAL ADHESIONS. Rho-associated kinases have specificity for a variety of substrates including MYOSIN-LIGHT-CHAIN PHOSPHATASE and LIM KINASES.
Actin-Related Protein 3
Cell Movement
Biopolymers
Actin-Related Protein 2
Phosphoprotein Phosphatases
Polymerization
CapZ Actin Capping Protein
Protein Kinases
rho GTP-Binding Proteins
Dendritic Spines
Contractile Proteins
Protein Binding
RNA, Small Interfering
Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.
Cytoskeletal Proteins
Actin Capping Proteins
Bicyclo Compounds, Heterocyclic
Phosphoric Monoester Hydrolases
Stress Fibers
Phosphatidylinositol 4,5-Diphosphate
A phosphoinositide present in all eukaryotic cells, particularly in the plasma membrane. It is the major substrate for receptor-stimulated phosphoinositidase C, with the consequent formation of inositol 1,4,5-triphosphate and diacylglycerol, and probably also for receptor-stimulated inositol phospholipid 3-kinase. (Kendrew, The Encyclopedia of Molecular Biology, 1994)
14-3-3 Proteins
A large family of signal-transducing adaptor proteins present in wide variety of eukaryotes. They are PHOSPHOSERINE and PHOSPHOTHREONINE binding proteins involved in important cellular processes including SIGNAL TRANSDUCTION; CELL CYCLE control; APOPTOSIS; and cellular stress responses. 14-3-3 proteins function by interacting with other signal-transducing proteins and effecting changes in their enzymatic activity and subcellular localization. The name 14-3-3 derives from numerical designations used in the original fractionation patterns of the proteins.
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Amino Acid Sequence
Protein Footprinting
A method for determining points of contact between interacting proteins or binding sites of proteins to nucleic acids. Protein footprinting utilizes a protein cutting reagent or protease. Protein cleavage is inhibited where the proteins, or nucleic acids and protein, contact each other. After completion of the cutting reaction, the remaining peptide fragments are analyzed by electrophoresis.
Glia Maturation Factor
Binding Sites
Growth Cones
Protein Transport
Cell Membrane Structures
Antibodies
Antibody Specificity
The three mouse actin-depolymerizing factor/cofilins evolved to fulfill cell-type-specific requirements for actin dynamics. (1/145)
Actin-depolymerizing factor (ADF)/cofilins are essential regulators of actin filament turnover. Several ADF/cofilin isoforms are found in multicellular organisms, but their biological differences have remained unclear. Herein, we show that three ADF/cofilins exist in mouse and most likely in all other mammalian species. Northern blot and in situ hybridization analyses demonstrate that cofilin-1 is expressed in most cell types of embryos and adult mice. Cofilin-2 is expressed in muscle cells and ADF is restricted to epithelia and endothelia. Although the three mouse ADF/cofilins do not show actin isoform specificity, they all depolymerize platelet actin filaments more efficiently than muscle actin. Furthermore, these ADF/cofilins are biochemically different. The epithelial-specific ADF is the most efficient in turning over actin filaments and promotes a stronger pH-dependent actin filament disassembly than the two other isoforms. The muscle-specific cofilin-2 has a weaker actin filament depolymerization activity and displays a 5-10-fold higher affinity for ATP-actin monomers than cofilin-1 and ADF. In steady-state assays, cofilin-2 also promotes filament assembly rather than disassembly. Taken together, these data suggest that the three biochemically distinct mammalian ADF/cofilin isoforms evolved to fulfill specific requirements for actin filament dynamics in different cell types. (+info)The human D2 dopamine receptor synergizes with the A2A adenosine receptor to stimulate adenylyl cyclase in PC12 cells. (2/145)
The adenosine A(2A) receptor and the dopamine D(2) receptor are prototypically coupled to G(s) and G(i)/G(o), respectively. In striatal intermediate spiny neurons, these receptors are colocalized in dendritic spines and act as mutual antagonists. This antagonism has been proposed to occur at the level of the receptors or of receptor-G protein coupling. We tested this model in PC12 cells which endogenously express A(2A) receptors. The human D(2) receptor was introduced into PC12 cells by stable transfection. A(2A)-agonist-mediated inhibition of D(2) agonist binding was absent in PC12 cell membranes but present in HEK293 cells transfected as a control. However, in the resulting PC12 cell lines, the action of the D(2) agonist quinpirole depended on the expression level of the D(2) receptor: at low and high receptor levels, the A(2A)-agonist-induced elevation of cAMP was enhanced and inhibited, respectively. Forskolin-stimulated cAMP formation was invariably inhibited by quinpirole. The effects of quinpirole were abolished by pretreatment with pertussis toxin. A(2A)-receptor-mediated cAMP formation was inhibited by other G(i)/G(o)-coupled receptors that were either endogenously present (P(2y12)-like receptor for ADP) or stably expressed after transfection (A(1) adenosine, metabotropic glutamate receptor-7A). Similarly, voltage activated Ca(2+) channels were inhibited by the endogenous P(2Y) receptor and by the heterologously expressed A(1) receptor but not by the D(2) receptor. These data indicate functional segregation of signaling components. Our observations are thus compatible with the proposed model that D(2) and A(2A) receptors are closely associated, but they highlight the fact that this interaction can also support synergism. (+info)Actin-depolymerizing factor and cofilin-1 play overlapping roles in promoting rapid F-actin depolymerization in mammalian nonmuscle cells. (3/145)
Actin-depolymerizing factor (ADF)/cofilins are small actin-binding proteins found in all eukaryotes. In vitro, ADF/cofilins promote actin dynamics by depolymerizing and severing actin filaments. However, whether ADF/cofilins contribute to actin dynamics in cells by disassembling "old" actin filaments or by promoting actin filament assembly through their severing activity is a matter of controversy. Analysis of mammalian ADF/cofilins is further complicated by the presence of multiple isoforms, which may contribute to actin dynamics by different mechanisms. We show that two isoforms, ADF and cofilin-1, are expressed in mouse NIH 3T3, B16F1, and Neuro 2A cells. Depleting cofilin-1 and/or ADF by siRNA leads to an accumulation of F-actin and to an increase in cell size. Cofilin-1 and ADF seem to play overlapping roles in cells, because the knockdown phenotype of either protein could be rescued by overexpression of the other one. Cofilin-1 and ADF knockdown cells also had defects in cell motility and cytokinesis, and these defects were most pronounced when both ADF and cofilin-1 were depleted. Fluorescence recovery after photobleaching analysis and studies with an actin monomer-sequestering drug, latrunculin-A, demonstrated that these phenotypes arose from diminished actin filament depolymerization rates. These data suggest that mammalian ADF and cofilin-1 promote cytoskeletal dynamics by depolymerizing actin filaments and that this activity is critical for several processes such as cytokinesis and cell motility. (+info)Maternal diet programs embryonic kidney gene expression. (4/145)
Human epidemiological data associating birth weight with adult disease suggest that organogenesis is "programmed" by maternal diet. In rats, protein restriction in pregnancy produces offspring with fewer renal glomeruli and higher systemic blood pressures than controls. We tested the hypothesis that maternal diet alters gene expression in the metanephros, the precursor of the definitive mammalian kidney. We demonstrated that maternal low-protein diet initiated when pregnancy starts and maintained to embryonic day 13, when the metanephros consists of mesenchyme surrounding a once-branched ureteric bud, is sufficient to significantly reduce glomerular numbers in offspring by about 20%. As assessed by representational difference analyses and real-time quantitative polymerase chain reactions, low-protein diet modulated gene expression in embryonic day 13 metanephroi. In particular, levels of prox-1, the ortholog of Drosophila transcription factor prospero, and cofilin-1, a regulator of the actin cytoskeleton, were reduced. During normal metanephrogenesis, prox-1 protein was first detected in mesenchymal cells around the ureteric tree and thereafter in nascent nephron epithelia, whereas cofilin-1 immunolocalized to bud derivatives and condensing mesenchyme. Previously, we reported that low-protein diets increased mesenchymal apoptosis cells when metanephrogenesis began and thereafter reduced numbers of precursor cells. Collectively, these studies prove that the maternal diet programs the embryonic kidney, altering cell turnover and gene expression at a time when nephrons and glomeruli have yet to form. The human implication is that the maternal diet ingested between conception and 5- 6-wk gestation contributes to the variation in glomerular numbers that are known to occur between healthy and hypertensive populations. (+info)Micropuncture gene delivery and intravital two-photon visualization of protein expression in rat kidney. (5/145)
Understanding molecular mechanisms of pathophysiology and disease processes requires the development of new methods for studying proteins in animal tissues and organs. Here, we describe a method for adenoviral-mediated gene transfer into tubule or endothelial cells of the rat kidney. The left kidney of an anesthetized rat was exposed and the lumens of superficial proximal tubules or vascular welling points were microinfused, usually for 20 min. The microinfusion solution contained adenovirus with a cDNA construct of either 1) Xenopus laevis actin depolymerizing factor/cofilin [XAC; wt-green fluorescent protein (GFP)], 2) actin-GFP, or 3) GFP. Sudan black-stained castor oil, injected into nearby tubules, allowed us to localize the microinfused structures for subsequent visualization. Two days later, the rat was anesthetized and the kidneys were fixed for tissue imaging or the left kidney was observed in vivo using two-photon microscopy. Expression of GFP and GFP-chimeric proteins was clearly seen in epithelial cells of the injected proximal tubules and the expressed proteins were localized similarly to their endogenously expressed counterparts. Only a minority of the cells in the virally exposed regions, however, expressed these proteins. Endothelial cells also expressed XAC-GFP after injection of the virus cDNA construct into vascular welling points. An advantage of the proximal tubule and vascular micropuncture approaches is that only minute amounts of virus are required to achieve protein expression in vivo. This micropuncture approach to gene transfer of the virus cDNA construct and intravital two-photon microscopy should be applicable to study of the behavior of any fluorescently tagged protein in the kidney and shows promise in studying renal physiology and pathophysiology. (+info)Ligation of cell surface-associated glucose-regulated protein 78 by receptor-recognized forms of alpha 2-macroglobulin: activation of p21-activated protein kinase-2-dependent signaling in murine peritoneal macrophages. (6/145)
Previous studies of the plasma proteinase inhibitor alpha2-macroglobulin (alpha2M) demonstrated that alpha2M-proteinase complexes (alpha2M*) modulate immune responses and promotes macrophage locomotion and chemotaxis. Alpha2M* binds to cell surface-associated glucose-regulated protein 78 (GRP78), which activates downstream signaling events. The role of p21-activated protein kinase-1 and -2 (PAK-1 and -2) in promoting cellular motility is well documented. In the current study, we examined the ability of alpha2M* to activate PAK-1 and PAK-2. Upon macrophage stimulation with alpha2M*, PAK-2 is autophosphorylated, resulting in increased kinase activity; however, PAK-1 is negligibly affected. Alpha2M*-stimulated macrophages showed a marked elevation in the levels of Rac x GTP. Receptor tyrosine phosphorylation upon binding of alpha2M* to GRP78, recruits PAK-2 to the plasma membrane via the adaptor protein NCK. Consistent with this hypothesis, silencing of GRP78 gene expression greatly attenuated the levels of membrane-associated PAK-2 and NCK. PAK-2 activity was markedly decreased by inhibition of tyrosine kinases and PI3K before alpha2M* stimulation. We further demonstrate that phosphorylation of Lin-11, Isl-1, Mec-3 (LIM) kinase and cofilin is promoted by treating macrophages with alpha2M*. Thus, alpha2M* regulates activation of the PAK-2-dependent motility mechanism in these cells. (+info)Description of a PCR-based technique for DNA splicing and mutagenesis by producing 5' overhangs with run through stop DNA synthesis utilizing Ara-C. (7/145)
BACKGROUND: Splicing of DNA molecules is an important task in molecular biology that facilitates cloning, mutagenesis and creation of chimeric genes. Mutagenesis and DNA splicing techniques exist, some requiring restriction enzymes, and others utilize staggered reannealing approaches. RESULTS: A method for DNA splicing and mutagenesis without restriction enzymes is described. The method is based on mild template-dependent polymerization arrest with two molecules of cytosine arabinose (Ara-C) incorporated into PCR primers. Two rounds of PCR are employed: the first PCR produces 5' overhangs that are utilized for DNA splicing. The second PCR is based on polymerization running through the Ara-C molecules to produce the desired final product. To illustrate application of the run through stop mutagenesis and DNA splicing technique, we have carried out splicing of two segments of the human cofilin 1 gene and introduced a mutational deletion into the product. CONCLUSION: We have demonstrated the utility of a new PCR-based method for carrying out DNA splicing and mutagenesis by incorporating Ara-C into the PCR primers. (+info)Stimulation of actin polymerization by filament severing. (8/145)
The extent and dynamics of actin polymerization in solution are calculated as functions of the filament severing rate, using a simple model of in vitro polymerization. The model is solved by both analytic theory and stochastic-growth simulation. The results show that severing essentially always enhances actin polymerization by freeing up barbed ends, if barbed-end cappers are present. Severing has much weaker effects if only pointed-end cappers are present. In the early stages of polymerization, the polymerized-actin concentration grows exponentially as a function of time. The exponential growth rate is given in terms of the severing rate, and the latter is given in terms of the maximum slope in a polymerization time course. Severing and branching are found to act synergistically. (+info)
Protein Kinase D Regulates Cell Migration by Direct Phosphorylation of the Cofilin Phosphatase Slingshot 1 Like | Cancer...
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Cofilin 1 - Wikipedia
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研究生前沿講座(討論班)第7周-山東大學物理學院
HSPH1
... has been shown to interact with Cofilin 1. GRCh38: Ensembl release 89: ENSG00000120694 - Ensembl, May 2017 GRCm38: ... 869 (1-2): 49-55. doi:10.1016/S0006-8993(00)02346-5. PMID 10865058. Strausberg RL, Feingold EA, Grouse LH, et al. (2003). " ... 1444 (1): 138-42. doi:10.1016/s0167-4781(98)00254-1. PMID 9931472. "Entrez Gene: HSPH1 heat shock 105kDa/110kDa protein 1". ... The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA ...
Reelin
... signaling leads to phosphorylation of actin-interacting protein cofilin 1 at ser3; this may stabilize the actin ... "Reelin stabilizes the actin cytoskeleton of neuronal processes by inducing n-cofilin phosphorylation at serine3". The Journal ... 112 (1-2): 33-45. doi:10.1016/S0169-328X(03)00032-9. PMID 12670700. Hack I, Hellwig S, Junghans D, Brunne B, Bock HH, Zhao S, ... 1 (2): 72-73. doi:10.1046/j.1535-7597.2001.00017.x. PMC 320825. PMID 15309195. Zaki M, Shehab M, El-Aleem AA, Abdel-Salam G, ...
Cyclase-associated protein family
In both yeast and mammals, CAPs appear to be involved in recycling G-actin monomers from ADF/cofilins for subsequent rounds of ... Moriyama K, Yahara I (April 2002). "Human CAP1 is a key factor in the recycling of cofilin and actin for rapid actin turnover ... A second unique function of CAP in regulating actin dynamics is its ability to specifically bind to pointed ends of cofilin- ... Shekhar S, Chung J, Kondev J, Gelles J, Goode BL (22 November 2019). "Synergy between Cyclase-associated protein and Cofilin ...
SSH2
ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play ... The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin ... 2005). "Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin". EMBO J. 24 (3): ... 2007). "The slingshot family of phosphatases mediates Rac1 regulation of cofilin phosphorylation, laminin-332 organization, and ...
Actinin alpha 4
Vallenius, T; Luukko K; Mäkelä T P (Apr 2000). "CLP-36 PDZ-LIM protein associates with nonmuscle alpha-actinin-1 and alpha- ... Otey CA, Pavalko FM, Burridge K (1990). "An interaction between alpha-actinin and the beta 1 integrin subunit in vitro". J. ... Vallenius T, Luukko K, Mäkelä TP (2000). "CLP-36 PDZ-LIM protein associates with nonmuscle alpha-actinin-1 and alpha-actinin-4 ... An actin interface distinct from that of gelsolin domain 1 and from ADF/cofilin". Eur. J. Biochem. 268 (23): 6165-75. doi: ...
LIMK2
Yang N, Higuchi O, Ohashi K, Nagata K, Wada A, Kangawa K, Nishida E, Mizuno K (Jun 1998). "Cofilin phosphorylation by LIM- ... Sumi T, Matsumoto K, Takai Y, Nakamura T (27 Dec 1999). "Cofilin phosphorylation and actin cytoskeletal dynamics regulated by ... Toshima J, Toshima JY, Takeuchi K, Mori R, Mizuno K (Aug 2001). "Cofilin phosphorylation and actin reorganization activities of ... Vardouli L, Moustakas A, Stournaras C (Mar 2005). "LIM-kinase 2 and cofilin phosphorylation mediate actin cytoskeleton ...
SSH3
ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play ... The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin ... a family of phosphatases that dephosphorylate ADF/cofilin". Cell. 108 (2): 233-46. doi:10.1016/S0092-8674(01)00638-9. PMID ... "Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin". The EMBO Journal. 24 (3): ...
SSH1
2004). "A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia". J. Cell Biol ... ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play ... 2007). "Coronin 1B coordinates Arp2/3 complex and cofilin activities at the leading edge". Cell. 128 (5): 915-29. doi:10.1016/j ... The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin ...
LIMK1
Yang N, Higuchi O, Ohashi K, Nagata K, Wada A, Kangawa K, Nishida E, Mizuno K (1998). "Cofilin phosphorylation by LIM-kinase 1 ... Birkenfeld J, Betz H, Roth D (January 2003). "Identification of cofilin and LIM-domain-containing protein kinase 1 as novel ... Nebl G, Meuer SC, Samstag Y (1996). "Dephosphorylation of serine 3 regulates nuclear translocation of cofilin". J. Biol. Chem. ... Toshima J, Toshima JY, Takeuchi K, Mori R, Mizuno K (2001). "Cofilin phosphorylation and actin reorganization activities of ...
Anne Bertolotti
"Prion-like protein aggregates exploit the RHO GTPase to cofilin-1 signaling pathway to enter cells". The EMBO Journal. 37 (6). ... One of the inhibitors discovered in Bertolotti's lab, Sephin1, has passed through favourable Phase 1 clinical trials in 2019 ... Münch, Christian; O'Brien, John; Bertolotti, Anne (2011-03-01). "Prion-like propagation of mutant superoxide dismutase-1 ... "Exposure of hydrophobic surfaces initiates aggregation of diverse ALS-causing superoxide dismutase-1 mutants". Journal of ...
YWHAZ
Birkenfeld J, Betz H, Roth D (January 2003). "Identification of cofilin and LIM-domain-containing protein kinase 1 as novel ... 9 (1): 143-54. doi:10.1089/jam.1996.9.143. PMID 10160204. Filoche M, Tai CF, Grotberg JB (July 2015). "Three-dimensional model ... 369 (Pt 1): 45-54. doi:10.1042/BJ20021152. PMC 1223062. PMID 12323073. Waterman MJ, Stavridi ES, Waterman JL, Halazonetis TD ( ... Koyama S, Williams LT, Kikuchi A (July 1995). "Characterization of the interaction of Raf-1 with ras p21 or 14-3-3 protein in ...
María Antonia Herrero
Enhanced docetaxel-mediated cytotoxicity in human prostate cancer cells through knockdown of cofilin-1 by carbon nanohorn ... 1 July 2016). "Design of Assembled Systems Based on Conjugated Polyphenylene Derivatives and Carbon Nanohorns". Chemistry - A ...
Caspase 11
"Caspase-11 regulates cell migration by promoting Aip1-Cofilin-mediated actin depolymerization". Nature Cell Biology. 9 (3): 276 ... Production of IL-1β downstream of caspase-11 requires another canonical inflammasome, called the NLRP3 inflammasome, that ... The CARD domain of caspase-11 has been shown to associate with AIP-1 and cofilin to facilitate actin depolymerization. In ... This mechanism contrasts to that of the canonical inflammasome, in which a bacterial ligand activates caspase-1 through an ...
TESK1
Toshima J, Toshima JY, Amano T, Yang N, Narumiya S, Mizuno K (2001). "Cofilin phosphorylation by protein kinase testicular ... Toshima J, Toshima JY, Takeuchi K, Mori R, Mizuno K (2001). "Cofilin phosphorylation and actin reorganization activities of ... Dual specificity testis-specific protein kinase 1 is an enzyme that in humans is encoded by the TESK1 gene. This gene product ... "Entrez Gene: TESK1 testis-specific kinase 1". Toshima JY, Toshima J, Watanabe T, Mizuno K (November 2001). "Binding of 14-3- ...
List of MeSH codes (D12.776)
... cofilin 1 MeSH D12.776.220.525.212.750 - cofilin 2 MeSH D12.776.220.525.212.875 - destrin MeSH D12.776.220.525.246.500 - actin- ... neuregulin-1 See List of MeSH codes (D12.776.476). MeSH D12.776.503.280.249.500 - mannose-binding lectin MeSH D12.776.503.280. ... hiv-1 reverse transcriptase MeSH D12.776.964.970.880.325 - gene products, env MeSH D12.776.964.970.880.325.330 - hiv envelope ... neurofibromin 1 MeSH D12.776.402.150.500.500 - p120 gtpase activating protein MeSH D12.776.402.300.700.500 - ras-GRF1 MeSH ...
List of MeSH codes (D05)
... cofilin 2 MeSH D05.750.078.730.212.875 - destrin MeSH D05.750.078.730.246 - actin-related protein 2-3 complex MeSH D05.750. ...
Destrin
The product of this gene belongs to the actin-binding proteins ADF (Actin-Depolymerizing Factor)/cofilin family. This family of ... Furthermore, the binding of actin by destrin and cofilin is regulated negatively by phosphorylation. Destrin can also sever ... Destrin binds actin and is thought to connect it as gelsolin segment-1 does. ...
Ashish Arora
... like UNC-60A and cofilin like UNC-60B proteins of Caenorhabditis elegans". Biomolecular NMR Assignments. 9 (2): 261-265. doi: ... Shukla, Vaibhav Kumar; Kabra, Ashish; Yadav, Rahul; Ono, Shoichiro; Kumar, Dinesh; Arora, Ashish (1 October 2015). "NMR ... 1 February 2017). "Unraveling the stereochemical and dynamic aspects of the catalytic site of bacterial peptidyl-tRNA hydrolase ...
Cofilin-2
Cofilin 2 (muscle) also known as CFL2 is a protein which in humans is encoded by the CFL2 gene. Cofilin is a widely distributed ... Cofilin-2 is a member of the AC group of proteins that also includes cofilin-1 (CFL1) and destrin (DSTN), all of which regulate ... "Mapping of human non-muscle type cofilin (CFL1) to chromosome 11q13 and muscle-type cofilin (CFL2) to chromosome 14". Ann. Hum ... 2006). "Cofilin cross-bridges adjacent actin protomers and replaces part of the longitudinal F-actin interface". J. Mol. Biol. ...
Cofilin 1
... n-cofilin), also known as CFL1, is a human gene, part of the ADF/cofilin family. Cofilin is a widely distributed intracellular ... "Entrez Gene: CFL1 cofilin 1 (non-muscle)". Chai X, Förster E, Zhao S, Bock HH, Frotscher M (January 2009). "Reelin stabilizes ... Lee K, Jung J, Kim M, Guidotti G (2001). "Interaction of the alpha subunit of Na,K-ATPase with cofilin". Biochem. J. 353 (Pt 2 ... Cofilin 1 has been shown to interact with HSPH1 and LIMK1. GRCh38: Ensembl release 89: ENSG00000172757 - Ensembl, May 2017 " ...
Dual-specificity phosphatase
In accordance with their proposed rule, proteins like ADF, cofilin and LIMK1 are slingshot substrates. Phosphatases of ... Regenerating Liver (PRLs): Three PRL genes were described in mammals (PRL-1, PRL-2 and PRL-3). They share a high sequence ...
Pyr1
The latter is the enzyme that uses ATP to phosphorylate and inactivate the actin-depolymerizing factor cofilin. When cofilin is ... In the presence of Pyr1, LIMK1 is inhibited, which means that the phosphorylation of cofilin decreases, which results in the ... Pyr 1 is a cell permeable competitive inhibitor of Lim Kinase (especially LIMK1). ...
Lim kinase
ADF/cofilin are the only substrates yet identified for the LIM kinases. LIM kinases directly phosphorylate and inactivate ... are actin-binding kinases that phosphorylate members of the ADF/cofilin family of actin binding and filament severing proteins ... LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal ... members of the cofilin family, resulting in stabilization of filamentous (F)-actin. Lim kinases are activated by signaling ...
Cadherin-catenin complex in learning and memory
Meanwhile, phosphorylation of PI3K by SRC activates RhoA which leads to activation of cofilin-P and disruption of filamentous ... When the WAVE-1 gene was disrupted in mice, it resulted in cognitive defects such as losses in learning and memory implicating ... 28 (1): 245-259. doi:10.1016/S0896-6273(00)00100-8. PMID 11086998. Tanaka, H; Shan, W; Phillips, GR; Arndt, K; Bozdagi, O; ... 51 (1): 43-56. doi:10.1016/j.neuron.2006.05.018. PMC 2587166. PMID 16815331. Ohkubo, T; Ozawa, M. (1999). "p120ctn Binds to the ...
LINGO1
... which then stimulates cofilin, which effectively reorganizes the actin cytoskeleton of the cell. In the case of neurons, ... The LINGO-1 structure has been shown to be highly stable both in its crystal form and in solution, thanks to its leucine-rich ... LINGO-1 is coded by the LINGO-1 gene, which is located on the human chromosome 15, more precisely on the locus 15q24-26, which ... LINGO-1 is expressed almost exclusively in the central nervous system (CNS). It can be found in the brain and in neurons and ...
40S ribosomal protein S18
2005). "Ribosomal protein S18 identified as a cofilin-binding protein by using phage display library". Mol. Cell. Biochem. 262 ... 239 (1): 144-9. doi:10.1111/j.1432-1033.1996.0144u.x. PMID 8706699. Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed ... 12 (1): 1-11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033. Mishra-Gorur K, Singer HA, Castellot JJ (2002 ... 1-2): 187-93. doi:10.1023/B:MCBI.0000038234.35936.1c. PMID 15532723. S2CID 30534195. Andersen JS, Lam YW, Leung AK, et al. ( ...
WDR1
1999). "Aip1p interacts with cofilin to disassemble actin filaments". J. Cell Biol. 145 (6): 1251-64. doi:10.1083/jcb.145.6. ... 327 (1): 268-75. doi:10.1016/j.bbrc.2004.11.156. PMID 15629458. Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a ... 56 (1): 59-69. doi:10.1006/geno.1998.5672. PMID 10036186. "Entrez Gene: WDR1 WD repeat domain 1". Dawson SJ, White LA (1992). " ... 23 (1): 94-101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157. Fujibuchi T, Abe Y, Takeuchi T, et al. (2005). "AIP1/WDR1 ...
MEMO1
"Memo is a cofilin-interacting protein that influences PLCgamma1 and cofilin activities, and is essential for maintaining ... 78 (1-2): 46-54. doi:10.1006/geno.2001.6640. PMID 11707072. Qiu C, Lienhard S, Hynes NE, Badache A, Leahy DJ (February 2008). " ... "Entrez Gene: Mediator of cell motility 1". Meira M, Masson R, Stagljar I, Lienhard S, Maurer F, Boulay A, Hynes NE (March 2009 ... Mediator of cell motility 1 is a protein that in humans is encoded by the MEMO1 gene. GRCh38: Ensembl release 89: ...
Cucurbitacin E
It causes a reduction of cell multiplication.[citation needed] This triterpene can inhibit the phosphorylation of the cofilin ... Drubin, D. G.; Lappalainen, P. (1997). "Cofilin promotes rapid actin filament turnover in vivo". Nature. 388 (6637): 78-82. ... "Cucurbitacin E as a new inhibitor of cofilin phosphorylation in human leukemia U937 cells". Bioorganic & Medicinal Chemistry ... 364 (1): 181-186. doi:10.1016/j.bbrc.2007.09.075. PMID 17942079. Clancy, D.; Birdsall, J. (2012). "Flies, worms and the Free ...
LMNA - 维基百科,自由的百科全书
核纤层蛋白 A/C(英语:Lamin A/C)是由人类基因LMNA 编码的蛋白质[1][2],属于核纤层蛋白家族。 ... 2000, 177 (1): 1-11. PMID 10960149. doi:10.1007/s002320001096.. *. Burke B, Mounkes LC, Stewart CL. The nuclear envelope in ... 2007, 53 (1): 46-52. PMID 17718387.. *. Genschel J, Schmidt HH. Mutations in the LMNA gene encoding lamin A/C. Hum. Mutat. ... Type 1/2
FLNB
62 (1): 121-3. doi:10.1292/jvms.62.121. PMID 10676904.. *. Chakarova C, Wehnert MS, Uhl K, et al. (2001). "Genomic structure ... Shoeman RL, Hartig R, Hauses C, Traub P (2003). "Organization of focal adhesion plaques is disrupted by action of the HIV-1 ...
Wiskott-Aldrich syndrome protein
... was once thought to bind cofilin but is now believed to enhance the interactions between the V domains and actin monomers, as ... doi:10.1016/S0092-8674(00)80732-1. PMID 10219243.. *^ Thrasher AJ, Burns SO (March 2010). "WASP: a key immunological ... 120 (1): 2-9. doi:10.1046/j.1365-2249.2000.01193.x. PMC 1905602. PMID 10759756.. ...
Neurofilament light polypeptide
67 (1): 37-46. doi:10.1086/302962. PMC 1287099. PMID 10841809.. *. De Jonghe P, Mersivanova I, Nelis E, Del Favero J, Martin JJ ... 45 (1): 30-2. doi:10.1159/000132421. PMID 3036423.. *. Frappier T, Regnouf F, Pradel LA (December 1987). "Binding of brain ... Pospelov VA, Pospelova TV, Julien JP (February 1994). "AP-1 and Krox-24 transcription factors activate the neurofilament light ... 10.1083/jcb.143.1.1. PMC 2132816. PMID 9763415.. *. Beaudet L, Charron G, Julien JP (May 1992). "Origin of the two mRNA species ...
Myofilament
Elastic filaments, 1 nm in diameter, are made of titin, a large springy protein. They run through the core of each thick ... Myofilaments are the filaments of myofibrils, constructed from proteins,[1] principally myosin or actin. Types of muscle are ...
鈉鉀泵 - 维基百科,自由的百科全书
Interaction of the alpha subunit of Na,K-ATPase with cofilin by K. Lee, J. Jung, M. Kim and G. Guidotti in The Biochemical ... 4.1/2/3/4/5/6 · 5.1/2/3/4/5/99 · 6.1-3(英语:Template:Ligases CO CS and CN)/4/5-6 ... 1]. 蛋白質交互作用對鈉鉀幫浦媒介的訊息傳遞是很重要的,如:鈉鉀幫浦與無接收子酪胺酸磷酸酶(Src,一種沒有受體得酪胺酸激酶)結合形成接收
MYH9
26 (1): 103-5. doi:10.1038/79063. PMID 10973259.. *^ a b c d Seri M, Pecci A, Di Bari F, Cusano R, Savino M, Panza E, et al. ( ... 37 (1): 112-20. doi:10.1097/AUD.0000000000000198. PMID 26226608.. *^ a b Kunishima S, Matsushita T, Kojima T, Sako M, Kimura F ... 26 (1): 106-8. doi:10.1038/79069. PMID 10973260.. *^ Seri M, Cusano R, Gangarossa S, Caridi G, Bordo D, Lo Nigro C, et al. ( ... 142 (1): 221-30. PMC 1886840. PMID 8424456.. *. Lalwani AK, Linthicum FH, Wilcox ER, Moore JK, Walters FC, San Agustin TB, ...
TLN1
Talin-1 is a protein that in humans is encoded by the TLN1 gene.[5][6] Talin-1 is ubiquitously expressed, and is localized to ... Human talin-1 is 270.0 kDa molecular weight and 2541 amino acids.[7] The N-terminal region of talin-1 is ~50 kDa in size and ... Talin-1 functions to mediate cell-cell adhesion via the linkage of integrins to the actin cytoskeleton and in the activation of ... In mammals talin-1 is ubiquitously expressed; talin-1 is found complexed to integrins and localized to intercalated discs of ...
Dynein
11 (1): 45-53. doi:10.1016/S0955-0674(99)80006-4.. *^ Moughamian, Armen J.; Osborn, Gregory E.; Lazarus, Jacob E.; Maday, ... ISBN 0-471-19279-1.. *. Schroer TA (2004). "Dynactin". Annual Review of Cell and Developmental Biology. 20: 759-79. doi:10.1146 ... Cytoplasmic dynein helps to position the Golgi complex and other organelles in the cell.[1] It also helps transport cargo ... 1] Cytoplasmic dynein moves processively along the microtubule; that is, one or the other of its stalks is always attached to ...
Na+/K+-ATPase
"Interaction of the alpha subunit of Na,K-ATPase with cofilin". The Biochemical Journal. 353 (Pt 2): 377-85. doi:10.1042/0264- ... 978-0-470-57095-1. .. *^ Howarth C, Gleeson P, Attwell D (July 2012). "Updated energy budgets for neural computation in the ... Each has unique properties and tissue expression patterns.[1] This enzyme belongs to the family of P-type ATPases. ... 252 (3 Pt 1): C328-34. doi:10.1152/ajpcell.1987.252.3.c328. PMID 3030131.. ...
ANK2
Ankyrin-B, also known as Ankyrin-2, is a protein which in humans is encoded by the ANK2 gene.[1][2] Ankyrin-B is ubiquitously ... 1 (2): 93-9. doi:10.1161/circgenetics.108.792192. PMID 20031550.. *^ Alders, M; Christiaans, I; Pagon, RA; Adam, MP; Ardinger, ... ankyrin-1 has shown to be essential in normal function of erythrocytes;[10] however, ankyrin-B and ankyrin-3 play essential ... Mohler, PJ; Davis, JQ; Davis, LH; Hoffman, JA; Michaely, P; Bennett, V (26 March 2004). "Inositol 1,4,5-trisphosphate receptor ...
KRT81
... , HB1, Hb-1, KRTHB1, MLN137, ghHkb1, hHAKB2-1, keratin 81. External IDs. OMIM: 602153 MGI: 1928858 HomoloGene: 55645 ... 2003). "Upregulation of the truncated basic hair keratin 1(hHb1-DeltaN) in carcinoma cells by Epstein-Barr virus (EBV)". Int. J ...
Myosin
... s (/ˈmaɪəsɪn, -oʊ-/[1][2]) are a superfamily of motor proteins best known for their roles in muscle contraction and in a ... 51 (1): 1-15. doi:10.1002/cm.10014. PMID 11810692.. *^ von der Ecken J, Heissler SM, Pathan-Chhatbar S, Manstein DJ, Raunser S ... 46 (1): 61-7. doi:10.1002/ajmg.1320460110. PMID 7684189.. *^ "Archived copy". Archived from the original on 2009-07-07. ... 13 (1): 13-26. doi:10.1038/nrm3248. PMID 22146746. S2CID 11853457.. *^ Zimmermann D, Santos A, Kovar DR, Rock RS (August 2015 ...
Cytokeratin
CK-1. CK-2. CK-3. CK-4. CK-5. CK-6. CK-9. CK-10. CK-11. CK-12. CK-13. CK-14. CK-15. CK-16. CK-17 ... They are an important component of intermediate filaments, which help cells resist mechanical stress.[1] Expression of these ...
Actin
Cofilin-actin complex finally dissociate after cofilin phosphorylation by nuclear LIM kinase. ... The most notable of these proteins are gelsolin and cofilin. These proteins first achieve a cut by binding to an actin monomer ... The import of actin into the nucleus (probably in a complex with cofilin) is facilitated by the import protein importin 9.[96] ... They possess a number of accessory proteins including ADF/cofilin, which has a molecular weight of 16kDa and is coded for by a ...
Microfilament
... cofilin. ADP bound cofilin severs ADP-rich regions nearest the (−)-ends. Upon release, the free actin monomer slowly ... Actin depolymerizing proteins such as ADF/cofilin.. The actin filament network in non-muscle cells is highly dynamic. The actin ... cell signalling is believed to activate cofilin, the actin-filament depolymerizing protein which binds to ADP-rich actin ... ISBN 1-4160-2388-7.. *^ Galland R, Leduc P, Guérin C, Peyrade D, Blanchoin L, Théry M (2013). "Fabrication of three-dimensional ...
Desmin
... was first described in 1976,[16] first purified in 1977,[17] the gene was cloned in 1989,[6] and the first knockout mouse was created in 1996.[18] The function of desmin has been deduced through studies in knockout mice. Desmin is one of the earliest protein markers for muscle tissue in embryogenesis as it is detected in the somites.[12] Although it is present early in the development of muscle cells, it is only expressed at low levels, and increases as the cell nears terminal differentiation. A similar protein, vimentin, is present in higher amounts during embryogenesis while desmin is present in higher amounts after differentiation. This suggests that there may be some interaction between the two in determining muscle cell differentiation. However desmin knockout mice develop normally and only experience defects later in life.[13] Since desmin is expressed at a low level during differentiation another protein may be able to compensate for desmin's function early in development but not ...
TNNT3
582 (1): 1-13. doi:10.1016/J.GENE.2016.01.006. PMC 5325693. PMID 26774798.. CS1 maint: Uses authors parameter (link). .mw- ... 1). Sequence homology and protein epitope allosteric similarity data suggest that TnT gene was originated by duplication of a ... 276 (5 Pt 1): C1162-70. doi:10.1152/ajpcell.1999.276.5.C1162. PMID 10329966.. ... 143 (1): 47-56. doi:10.1111/j.1432-1033.1984.tb08337.x. PMID 6468390.. ...
Coronin
Cai L, Marshall TW, Uetrecht AC, Schafer DA, Bear JE (May 2007). "Coronin 1B coordinates Arp2/3 complex and cofilin activities ... Whereas coronin 1 was required for chemokine-mediated migration, it was dispensable for T cell antigen receptor functions in T ... 107 (1): 227-39. PMID 8175911. Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of ... N-terminus signature region is reduced to 5aa and appears in front of each WD-repeat core domain (e.g., CRN7, POD-1) Human ...
CLCN5
When the nascent endosome forms, the recruitment of cofilin by ClC-5 is a prerequisite for the localized dissolution of the ... Hryciw DH, Wang Y, Devuyst O, Pollock CA, Poronnik P, Guggino WB (October 2003). "Cofilin interacts with ClC-5 and regulates ... Hryciw DH, Wang Y, Devuyst O, Pollock CA, Poronnik P, Guggino WB (October 2003). "Cofilin interacts with ClC-5 and regulates ... It was demonstrated at the C-terminus of ClC-5 binds the actin-depolymerizing protein cofilin. ...
ADF-H domain
ADF/cofilins, which include ADF, cofilin, destrin, actophorin, coactosin, depactin and glia maturation factors (GMFs) beta and ... ADF/cofilins are small actin-binding proteins composed of a single ADF-H domain. They bind both actin-monomers and filaments ... ADF/cofilins bind ADP-actin with higher affinity than ATP-actin and inhibit the spontaneous nucleotide exchange on actin ... cofilin". J. Biol. Chem. 277 (45): 43089-95. doi:10.1074/jbc.M208225200. PMID 12207032. Liu LX, Xu H, Weller PF, Shi A, Debnath ...
SYNGAP1
Spine heads are enlarged due to the increased phosphorylation of cofilin, leading to a decrease in F-actin severing and ... 321 (1): 210-8. doi:10.1016/j.bbrc.2004.06.122. PMID 15358237. Rumbaugh G, Adams JP, Kim JH, Huganir RL (March 2006). "SynGAP ... 1005 (1-2): 44-50. doi:10.1016/j.brainres.2004.01.032. PMID 15044063. S2CID 33854259. Brandenberger R, Wei H, Zhang S, Lei S, ... 21 (12): 1-13. doi:10.1038/s41593-018-0268-0. ISSN 1546-1726. PMC 6309426. PMID 30455457. Vlaskamp DR, Shaw BJ, Burgess R, Mei ...
Benita Katzenellenbogen
Madak-Erdogan, Zeynep; Ventrella, Rosa; Petry, Luke; Katzenellenbogen, Benita S (2014). "Novel Roles for ERK5 and Cofilin as ... 92 (1): 125-34. doi:10.1210/endo-92-1-125. PMID 4681918. "People , Carl R. Woese Institute for Genomic Biology". www.igb. ... 31 (1): 226-36. doi:10.1128/MCB.00821-10. PMC 3019850. PMID 20956553. Harrington, William R; Kim, Sung Hoon; Funk, Cory C; ... 105 (1): 33-40. doi:10.1210/endo-105-1-33. PMID 446414. Gong, Ping; Madak-Erdogan, Zeynep; Li, Jilong; Cheng, Jianlin; ...
Stress fiber
LIM-kinase will in turn phosphorylate and inactivate cofilin, which will prevent the breakdown and recycling of actin filaments ... 28 (1-2): 65-76. doi:10.1007/s10555-008-9170-7. PMID 19160018. S2CID 33869424. Kimura, K.; Ito, M.; Amano, M.; Chihara, K.; ... 6 (1): 21-30. doi:10.1038/ncb1075. PMC 2605950. PMID 14647292. Maul, R. S. (February 3, 2003). "EPLIN regulates actin dynamics ... 6 (1): 275-302. doi:10.1146/annurev.bioeng.6.040803.140040. PMID 15255771. Chen, Christopher S.; Tan, John; Tien, Joe (August ...
No data available that match "cofilin 1"
Actin depolymerization2
- Mitochondrial fission and mitophagy depend on cofilin-mediated actin depolymerization activity at the mitochondrial fission site. (cocites.com)
- Shashank's paper on Srv2/CAP and Cofilin synergizing in ultrafast actin depolymerization has been published at Nature Communications. (goodelab.org)
Cells1
- This improved 51059-44-0 manufacture insulin discharge resulted from an increased pancreatic parasympathetic insight on islets and from an increased awareness of -cells to cholinergic and GLP-1 arousal. (molecularcircuit.com)
Development3
- Auditory brainstem-evoked response testing, immunofluorescence imaging, scanning electron microscopy, and biochemical labeling techniques were used to study how the ADF/cofilin family of actin filament severing and depolymerizing proteins contributes to the development of the stereocilia bundle. (purdue.edu)
- A novel role of differentiation-inducing factor-1 in Dictyostelium development, assessed by the restoration of a developmental defect in a mutant lacking mitogen-activated protein kinase ERK2. (nbrp.jp)
- Cytoskeletal regulators, such as for example Rho GTPases 51059-44-0 manufacture or cofilin, mediate the axonal and neurite development inhibitory actions of Nogo-A (28,29). (molecularcircuit.com)
Activity1
- The activity of this channel regulates ADF/cofilins and the actin at stereocilia tips. (purdue.edu)
Nature Communications1
- Genomic architecture and prediction of censored time-to-event phenotypes with a Bayesian genome-wide analysis," Nature Communications , vol. 12, no. 1. (ist.ac.at)
Journal1
- J. L. Fischer and D. Matthes, "The waiting time phenomenon in spatially discretized porous medium and thin film equations," SIAM Journal on Numerical Analysis , vol. 59, no. 1. (ist.ac.at)