Perilymph: The fluid separating the membranous labyrinth from the osseous labyrinth of the ear. It is entirely separate from the ENDOLYMPH which is contained in the membranous labyrinth. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1396, 642)Cochlea: The part of the inner ear (LABYRINTH) that is concerned with hearing. It forms the anterior part of the labyrinth, as a snail-like structure that is situated almost horizontally anterior to the VESTIBULAR LABYRINTH.Scala Tympani: The lower chamber of the COCHLEA, extending from the round window to the helicotrema (the opening at the apex that connects the PERILYMPH-filled spaces of scala tympani and SCALA VESTIBULI).Endolymph: The lymph fluid found in the membranous labyrinth of the ear. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Ion-Selective Electrodes: Electrodes which can be used to measure the concentration of particular ions in cells, tissues, or solutions.Labyrinthine Fluids: Fluids found within the osseous labyrinth (PERILYMPH) and the membranous labyrinth (ENDOLYMPH) of the inner ear. (From Gray's Anatomy, 30th American ed, p1328, 1332)Hair Cells, Auditory: Sensory cells in the organ of Corti, characterized by their apical stereocilia (hair-like projections). The inner and outer hair cells, as defined by their proximity to the core of spongy bone (the modiolus), change morphologically along the COCHLEA. Towards the cochlear apex, the length of hair cell bodies and their apical STEREOCILIA increase, allowing differential responses to various frequencies of sound.Neurotology: A subspecialty of otolaryngology dealing with the parts of the nervous system related to the ear.Audiology: The study of hearing and hearing impairment.Speech-Language Pathology: The study of speech or language disorders and their diagnosis and correction.Hearing Disorders: Conditions that impair the transmission of auditory impulses and information from the level of the ear to the temporal cortices, including the sensorineural pathways.Serial Publications: Publications in any medium issued in successive parts bearing numerical or chronological designations and intended to be continued indefinitely. (ALA Glossary of Library and Information Science, 1983, p203)Hearing Tests: Part of an ear examination that measures the ability of sound to reach the brain.Tinnitus: A nonspecific symptom of hearing disorder characterized by the sensation of buzzing, ringing, clicking, pulsations, and other noises in the ear. Objective tinnitus refers to noises generated from within the ear or adjacent structures that can be heard by other individuals. The term subjective tinnitus is used when the sound is audible only to the affected individual. Tinnitus may occur as a manifestation of COCHLEAR DISEASES; VESTIBULOCOCHLEAR NERVE DISEASES; INTRACRANIAL HYPERTENSION; CRANIOCEREBRAL TRAUMA; and other conditions.N-Methylaspartate: An amino acid that, as the D-isomer, is the defining agonist for the NMDA receptor subtype of glutamate receptors (RECEPTORS, NMDA).Receptors, Amino Acid: Cell surface proteins that bind amino acids and trigger changes which influence the behavior of cells. Glutamate receptors are the most common receptors for fast excitatory synaptic transmission in the vertebrate central nervous system, and GAMMA-AMINOBUTYRIC ACID and glycine receptors are the most common receptors for fast inhibition.Excitatory Amino Acids: Endogenous amino acids released by neurons as excitatory neurotransmitters. Glutamic acid is the most common excitatory neurotransmitter in the brain. Aspartic acid has been regarded as an excitatory transmitter for many years, but the extent of its role as a transmitter is unclear.Government Publications as Topic: Discussion of documents issued by local, regional, or national governments or by their agencies or subdivisions.Reference Books: Books designed by the arrangement and treatment of their subject matter to be consulted for definite terms of information rather than to be read consecutively. Reference books include DICTIONARIES; ENCYCLOPEDIAS; ATLASES; etc. (From the ALA Glossary of Library and Information Science, 1983)Receptors, N-Methyl-D-Aspartate: A class of ionotropic glutamate receptors characterized by affinity for N-methyl-D-aspartate. NMDA receptors have an allosteric binding site for glycine which must be occupied for the channel to open efficiently and a site within the channel itself to which magnesium ions bind in a voltage-dependent manner. The positive voltage dependence of channel conductance and the high permeability of the conducting channel to calcium ions (as well as to monovalent cations) are important in excitotoxicity and neuronal plasticity.ArchivesBiological Science Disciplines: All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.PubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.Hereditary Sensory and Motor Neuropathy: A group of slowly progressive inherited disorders affecting motor and sensory peripheral nerves. Subtypes include HMSNs I-VII. HMSN I and II both refer to CHARCOT-MARIE-TOOTH DISEASE. HMSN III refers to hypertrophic neuropathy of infancy. HMSN IV refers to REFSUM DISEASE. HMSN V refers to a condition marked by a hereditary motor and sensory neuropathy associated with spastic paraplegia (see SPASTIC PARAPLEGIA, HEREDITARY). HMSN VI refers to HMSN associated with an inherited optic atrophy (OPTIC ATROPHIES, HEREDITARY), and HMSN VII refers to HMSN associated with retinitis pigmentosa. (From Adams et al., Principles of Neurology, 6th ed, p1343)Directories as Topic: Lists of persons or organizations, systematically arranged, usually in alphabetic or classed order, giving address, affiliations, etc., for individuals, and giving address, officers, functions, and similar data for organizations. (ALA Glossary of Library and Information Science, 1983)Charcot-Marie-Tooth Disease: A hereditary motor and sensory neuropathy transmitted most often as an autosomal dominant trait and characterized by progressive distal wasting and loss of reflexes in the muscles of the legs (and occasionally involving the arms). Onset is usually in the second to fourth decade of life. This condition has been divided into two subtypes, hereditary motor and sensory neuropathy (HMSN) types I and II. HMSN I is associated with abnormal nerve conduction velocities and nerve hypertrophy, features not seen in HMSN II. (Adams et al., Principles of Neurology, 6th ed, p1343)North CarolinaB-Lymphocytes: Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation.Cell Cycle: The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.Proto-Oncogene Proteins c-akt: A protein-serine-threonine kinase that is activated by PHOSPHORYLATION in response to GROWTH FACTORS or INSULIN. It plays a major role in cell metabolism, growth, and survival as a core component of SIGNAL TRANSDUCTION. Three isoforms have been described in mammalian cells.Cell Line, Tumor: A cell line derived from cultured tumor cells.Ciliary Motility Disorders: Conditions caused by abnormal CILIA movement in the body, usually causing KARTAGENER SYNDROME, chronic respiratory disorders, chronic SINUSITIS, and chronic OTITIS. Abnormal ciliary beating is likely due to defects in any of the 200 plus ciliary proteins, such as missing motor enzyme DYNEIN arms.Extracellular Signal-Regulated MAP Kinases: A mitogen-activated protein kinase subfamily that is widely expressed and plays a role in regulation of MEIOSIS; MITOSIS; and post mitotic functions in differentiated cells. The extracellular signal regulated MAP kinases are regulated by a broad variety of CELL SURFACE RECEPTORS and can be activated by certain CARCINOGENS.Manuscripts as Topic: Compositions written by hand, as one written before the invention or adoption of printing. A manuscript may also refer to a handwritten copy of an ancient author. A manuscript may be handwritten or typewritten as distinguished from a printed copy, especially the copy of a writer's work from which printed copies are made. (Webster, 3d ed)GermanyManuscripts, MedicalConflict of Interest: A situation in which an individual might benefit personally from official or professional actions. It includes a conflict between a person's private interests and official responsibilities in a position of trust. The term is not restricted to government officials. The concept refers both to actual conflict of interest and the appearance or perception of conflict.Peer Review, Research: The evaluation by experts of the quality and pertinence of research or research proposals of other experts in the same field. Peer review is used by editors in deciding which submissions warrant publication, by granting agencies to determine which proposals should be funded, and by academic institutions in tenure decisions.Disclosure: Revealing of information, by oral or written communication.Financial Support: The provision of monetary resources including money or capital and credit; obtaining or furnishing money or capital for a purchase or enterprise and the funds so obtained. (From Random House Unabridged Dictionary, 2d ed.)Histiocytic Necrotizing Lymphadenitis: Development of lesions in the lymph node characterized by infiltration of the cortex or paracortex by large collections of proliferating histiocytes and complete or, more often, incomplete necrosis of lymphoid tissue.Stria Vascularis: A layer of stratified EPITHELIUM forming the endolymphatic border of the cochlear duct at the lateral wall of the cochlea. Stria vascularis contains primarily three cell types (marginal, intermediate, and basal), and capillaries. The marginal cells directly facing the ENDOLYMPH are important in producing ion gradients and endochoclear potential.Spiral Ligament of Cochlea: A spiral thickening of the fibrous lining of the cochlear wall. Spiral ligament secures the membranous COCHLEAR DUCT to the bony spiral canal of the COCHLEA. Its spiral ligament fibrocytes function in conjunction with the STRIA VASCULARIS to mediate cochlear ion homeostasis.Organ of Corti: The spiral EPITHELIUM containing sensory AUDITORY HAIR CELLS and supporting cells in the cochlea. Organ of Corti, situated on the BASILAR MEMBRANE and overlaid by a gelatinous TECTORIAL MEMBRANE, converts sound-induced mechanical waves to neural impulses to the brain.Ear, Inner: The essential part of the hearing organ consists of two labyrinthine compartments: the bony labyrinthine and the membranous labyrinth. The bony labyrinth is a complex of three interconnecting cavities or spaces (COCHLEA; VESTIBULAR LABYRINTH; and SEMICIRCULAR CANALS) in the TEMPORAL BONE. Within the bony labyrinth lies the membranous labyrinth which is a complex of sacs and tubules (COCHLEAR DUCT; SACCULE AND UTRICLE; and SEMICIRCULAR DUCTS) forming a continuous space enclosed by EPITHELIUM and connective tissue. These spaces are filled with LABYRINTHINE FLUIDS of various compositions.Meniere Disease: A disease of the inner ear (LABYRINTH) that is characterized by fluctuating SENSORINEURAL HEARING LOSS; TINNITUS; episodic VERTIGO; and aural fullness. It is the most common form of endolymphatic hydrops.Ear: The hearing and equilibrium system of the body. It consists of three parts: the EXTERNAL EAR, the MIDDLE EAR, and the INNER EAR. Sound waves are transmitted through this organ where vibration is transduced to nerve signals that pass through the ACOUSTIC NERVE to the CENTRAL NERVOUS SYSTEM. The inner ear also contains the vestibular organ that maintains equilibrium by transducing signals to the VESTIBULAR NERVE.Glutamic Acid: A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.Ear, Middle: The space and structures directly internal to the TYMPANIC MEMBRANE and external to the inner ear (LABYRINTH). Its major components include the AUDITORY OSSICLES and the EUSTACHIAN TUBE that connects the cavity of middle ear (tympanic cavity) to the upper part of the throat.Hearing Loss: A general term for the complete or partial loss of the ability to hear from one or both ears.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.
Supporting cells contribute to control of hearing sensitivity. (1/77)The mammalian hearing organ, the organ of Corti, was studied in an in vitro preparation of the guinea pig temporal bone. As in vivo, the hearing organ responded with an electrical potential, the cochlear microphonic potential, when stimulated with a test tone. After exposure to intense sound, the response to the test tone was reduced. The electrical response either recovered within 10-20 min or remained permanently reduced, thus corresponding to a temporary or sustained loss of sensitivity. Using laser scanning confocal microscopy, stimulus-induced changes of the cellular structure of the hearing organ were simultaneously studied. The cells in the organ were labeled with two fluorescent probes, a membrane dye and a cytoplasm dye, showing enzymatic activity in living cells. Confocal microscopy images were collected and compared before and after intense sound exposure. The results were as follows. (1) The organ of Corti could be divided into two different structural entities in terms of their susceptibility to damage: an inner, structurally stable region comprised of the inner hair cell with its supporting cells and the inner and outer pillar cells; and an outer region that exhibited dynamic structural changes and consisted of the outer hair cells and the third Deiters' cell with its attached Hensen's cells. (2) Exposure to intense sound caused the Deiters' cells and Hensen's cells to move in toward the center of the cochlear turn. (3) This event coincided with a reduced sensitivity to the test tone (i.e., reduced cochlear microphonic potential). (4) The displacement and sensitivity loss could be reversible. It is concluded that these observations have relevance for understanding the mechanisms behind hearing loss after noise exposure and that the supporting cells take an active part in protection against trauma during high-intensity sound exposure. (+info)
The effects of tone exposure on the inner ear functions in the guinea pig: impact tone vs. steady state tone. (2/77)The damage-risk criterion (DRC) for hearing supposes that sound exposure with equal energy implies equal risk for noise-induced hearing loss (NIHL). We measured cochlear microphonics (CM), compound action potential (CAP), endocochlear potential (EP) and K+ ion concentration in the scala media, to see if the same level of Leq24h (impact tone and steady state tone) induced the same physiological changes in the inner ear function or not. Regarding the equal energy principle (EEP), we also examined if the EEP is appropriate or not at exposure of moderate level tone. We also checked how the time interval between impact tones affects or not the inner ear functions at the same Leq24h tone exposure. Therefore we used exposure at 1 pulse/second or 1 pulse/3 seconds and steady state tone exposure at Leq24h=90, 85 and 80 dB. The results are the following. Both steady state and impact tone exposure causes change of the electrophysiological data. First, CM maximum output voltage after exposure to impact tone of 115 dB (Leq24h=90 dB) was lower than after exposure to a 8 kHz steady state tone of 90 dB. CAP threshold (below 10 microV) obtained after the 115 and 110 dB exposure of impact tone were 5-10 dB higher than that of steady state tone of 90 dB. The negative EP induced by impact tone exposures showed the same tendency as the CM experiments. Having more frequent pulses (1 pulse/second vs. to 1 pulse/3 seconds) showed more inhibition. The K+ concentration time course remained similar to the control when the Leq24h was low (80 dB). Impact tone exposure induced stronger effects to the inner ear at exposure of moderate level tone than that of steady state tone of Leq24h. (+info)
Comparative study of effects of impact tone and steady state tone exposure: EP and concentration of K+ ion and Na+ ion. (3/77)To test the adequacy of equal energy principle (EEP), guinea pigs were exposed to impact tone. The changes in electrophysiological data, namely endocochlear potential (EP) and the change in K+ ion and Na+ ion concentrations in the endolymph were investigated. The frequency of impact tone was 1 pulse/second or 1 pulse/3 seconds. The steady state tone had Leq24h = 100, 95, 90 or 85 dB, and impact tone had Leq24h = 95, 90 or 85 dB. The results are the following. Both steady state and impact tone exposure cause changes of electrophysiological data. The effects on the absolute value of negative EP induced by impact tone exposures were smaller than that of steady state tone of the same Leq. The rate of pulses was also an important factor for impact tone exposure. Impact tone exposure of 1 pulse/second caused smaller absolute value of negative EP than that of 1 pulse/3 seconds. The K+ ion concentration time course in the endolymph remained similar to the control (Exp. 1) only in Exp. 8 (85 dB; the lowest steady state noise exposure in our experiments), but no decrease in the K+ ion concentration was detected in the other experiments, suggesting an alteration in the K+ ion flow. The Na+ ion concentration time course was also influenced showing no increase in Na+ ion concentration compared to the control (Exp. 1c) and the lowest steady-state exposure experiment (Exp. 8c). Our experimental results suggest that both the K+ ion and Na+ ion movement are altered by tone exposure. We found also that the different types of noise exposure with the same Leq value does not exhibit the same changes. Leq24h is not an accurate damage risk criteria. (+info)
A targeted deletion in alpha-tectorin reveals that the tectorial membrane is required for the gain and timing of cochlear feedback. (4/77)alpha-tectorin is an extracellular matrix molecule of the inner ear. Mice homozygous for a targeted deletion in a-tectorin have tectorial membranes that are detached from the cochlear epithelium and lack all noncollagenous matrix, but the architecture of the organ of Corti is otherwise normal. The basilar membranes of wild-type and alpha-tectorin mutant mice are tuned, but the alpha-tectorin mutants are 35 dB less sensitive. Basilar membrane responses of wild-type mice exhibit a second resonance, indicating that the tectorial membrane provides an inertial mass against which outer hair cells can exert forces. Cochlear microphonics recorded in alpha-tectorin mutants differ in both phase and symmetry relative to those of wild-type mice. Thus, the tectorial membrane ensures that outer hair cells can effectively respond to basilar membrane motion and that feedback is delivered with the appropriate gain and timing required for amplification. (+info)
KCNJ10 (Kir4.1) potassium channel knockout abolishes endocochlear potential. (5/77)Stria vascularis of the cochlea generates the endocochlear potential and secretes K(+). K(+) is the main charge carrier and the endocochlear potential the main driving force for the sensory transduction that leads to hearing. Stria vascularis consists of two barriers, marginal cells that secrete potassium and basal cells that are coupled via gap junctions to intermediate cells. Mice lacking the KCNJ10 (Kir4.1) K(+) channel in strial intermediate cells did not generate an endocochlear potential. Endolymph volume and K(+) concentration ([K(+)]) were reduced. These studies establish that the KCNJ10 K(+) channel provides the molecular mechanism for generation of the endocochlear potential in concert with other transport pathways that establish the [K(+)] difference across the channel. KCNJ10 is also a limiting pathway for K(+) secretion. (+info)
Loud sound-induced changes in cochlear mechanics. (6/77)To investigate the inner ear response to intense sound and the mechanisms behind temporary threshold shifts, anesthetized guinea pigs were exposed to tones at 100-112 dB SPL. Basilar membrane vibration was measured using laser velocimetry, and the cochlear microphonic potential, compound action potential of the auditory nerve, and local electric AC potentials in the organ of Corti were used as additional indicators of cochlear function. After exposure to a 12-kHz intense tone, basilar membrane vibrations in response to probe tones at the characteristic frequency of the recording location (17 kHz) were transiently reduced. This reduction recovered over the course of 50 ms in most cases. Organ of Corti AC potentials were also reduced and recovered with a time course similar to the basilar membrane. When using a probe tone at either 1 or 4 kHz, organ of Corti AC potentials were unaffected by loud sound, indicating that transducer channels remained intact. In most experiments, both the basilar membrane and the cochlear microphonic response to the 12-kHz overstimulation was constant throughout the duration of the intense stimulus, despite a large loss of cochlear sensitivity. It is concluded that the reduction of basilar membrane velocity that followed loud sound was caused by changes in cochlear amplification and that the cochlear response to intense stimulation is determined by the passive mechanical properties of the inner ear structures. (+info)
NompC TRP channel required for vertebrate sensory hair cell mechanotransduction. (7/77)The senses of hearing and balance in vertebrates rely on the sensory hair cells (HCs) of the inner ear. The central element of the HC's transduction apparatus is a mechanically gated ion channel of unknown identity. Here we report that the zebrafish ortholog of Drosophila no mechanoreceptor potential C (nompC), which encodes a transient receptor potential (TRP) channel, is critical for HC mechanotransduction. In zebrafish larvae, nompC is selectively expressed in sensory HCs. Morpholino-mediated removal of nompC function eliminated transduction-dependent endocytosis and electrical responses in HCs, resulting in larval deafness and imbalance. These observations indicate that nompC encodes a vertebrate HC mechanotransduction channel. (+info)
Stiffness of the gerbil basilar membrane: radial and longitudinal variations. (8/77)Experimental data on the mechanical properties of the tissues of the mammalian cochlea are essential for understanding the frequency- and location-dependent motion patterns that result in response to incoming sound waves. Within the cochlea, sound-induced vibrations are transduced into neural activity by the organ of Corti, the gross motion of which is dependent on the motion of the underlying basilar membrane. In this study we present data on stiffness of the gerbil basilar membrane measured at multiple positions within a cochlear cross section and at multiple locations along the length of the cochlea. A basic analysis of these data using relatively simple models of cochlear mechanics reveals our most important result: the experimentally measured longitudinal stiffness gradient at the middle of the pectinate zone of the basilar membrane (4.43 dB/mm) can account for changes of best frequency along the length of the cochlea. Furthermore, our results indicate qualitative changes of stiffness-deflection curves as a function of radial position; in particular, there are differences in the rate of stiffness growth with increasing tissue deflection. Longitudinal coupling within the basilar membrane/organ of Corti complex is determined to have a space constant of 21 microm in the middle turn of the cochlea. The bulk of our data was obtained in the hemicochlea preparation, and we include a comparison of this set of data to data obtained in vivo. (+info)
List of MeSH codes (G11)
... cochlear microphonic potentials MeSH G11.561.250.370.300 --- evoked potentials, auditory, brain stem MeSH G11.561.250.385 --- ... evoked potentials, motor MeSH G11.561.250.400 --- evoked potentials, somatosensory MeSH G11.561.250.425 --- evoked potentials, ... event-related potentials, p300 MeSH G11.561.250.370 --- evoked potentials, auditory MeSH G11.561.250.370.223 --- ... visual MeSH G11.561.250.440 --- excitatory postsynaptic potentials MeSH G11.561.450.100 --- action potentials MeSH G11.561. ...
List of MeSH codes (G07)
... cochlear microphonic potentials MeSH G07.453.450.370.300 --- evoked potentials, auditory, brain stem MeSH G07.453.450.385 --- ... evoked potentials, motor MeSH G07.453.450.400 --- evoked potentials, somatosensory MeSH G07.453.450.425 --- evoked potentials, ... evoked potentials MeSH G07.453.450.250 --- contingent negative variation MeSH G07.453.450.350 --- event-related potentials, ... membrane potentials MeSH G07.453.697.100 --- action potentials MeSH G07.453.697.100.570 --- myoelectric complex, migrating MeSH ...
Cochlear microphonic (CM) Summating potential (SP) Action potential (AP) As described above, the cochlear microphonic (CM) is ... A resting endolymphatic potential of a normal cochlea is + 80 mV. There are at least 3 other potentials generated upon cochlear ... 1954). "Exploration of cochlear potentials in guinea pigs with a micro-electrode". Journal of the Acoustical Society of America ... This measurable AC voltage is called the cochlear microphonic (CM), which mimics the stimulus. The hair cells function as a ...
Frequency following response
This phenomenon came to be known as the cochlear microphonic (CM). The FFR may have been accidentally discovered back in 1930; ... Evoked potential Auditory brainstem response Burkard, R., Don, M., & Eggermont, J. J. Auditory evoked potentials: Basic ... In 1930, Wever and Bray discovered a potential called the "Wever-Bray effect". They originally believed that the potential ... FFRs have the potential to be used to evaluate the neural representation of speech sounds processed by different strategies ...
Information from cochlear potentials and genetic mutations helps localize the lesion site in auditory neuropathy | Genome...
It has been estimated that over one third of subjects with AN are affected by peripheral neuropathies . In addition, optic neuropathies and other CNS disorders have been found in association with AN (non-isolated AN, Table 1). In this group of subjects the hearing disorder is underlain by several genetic defects, all resulting in neuronal loss and demyelination in peripheral and/or cranial nerves, and the site of the lesion is invariably postsynaptic.. AN has been identified at relatively high frequency in patients affected by Charcot-Marie-Tooth (CMT) disease. The first gene associated with AN in this group was the myelin protein zero (MPZ) gene  encoding a protein included in the compact myelin that plays a crucial role in myelin formation and adhesion. A missense mutation in MPZ was identified in a family affected by dominant AN and demyelinating sensorimotor neuropathy . Post-mortem examination carried out on one member of this family revealed preserved hair cells in the cochlea, ...
Assessments of CAP amplitude (Fig. 2) and intraaxonal dye diffusion (Fig. 3) show that direct application of PEG to crush-severed sciatic nerves usually (97% of all attempts) rapidly restores physiological and morphological continuity to at least some axons in the sciatic nerve. In fact, continuity may be restored to many proximal and distal axonal halves (with unknown specificity) since CAP amplitudes of PEG-fused nerves on average are 50 to 89% of CAP amplitudes of intact-control or sham-operated nerves. FF asymmetry scores (Fig. 4) provide quantitative assessment of hindlimb motor behavior and show significantly faster recovery of functional behavior associated with direct application of PEG to crush-severed sciatic nerves. This finding for FF asymmetry scores is consistent with our measures of physiological and morphological continuity.. Video observations of FF trials and of open field trials also show rapid behavioral improvement associated with direct application of PEG to crush-severed ...
Frequent earbud headphone use increases risk for 'hidden hearing loss': study | Atasteofcreole's Blog
http://www.nydailynews.com/news/national/earbud-increases-hidden-hearing-loss-risk-study-article-1.2230945 http://sciencedaily.com/releases/2014/05/140507142804.htm Researchers at Harvard Medical Schools Eaton Peabody Laboratory learned you can lose up to 90 percent of your cochlear nerve fibers from frequent earbud use. Now hear this: Earbud headphones, even at low volume, may be causing permanent damage to your hearing. For decades, scientists have looked, almost exclusively, at the loss of…
A lateral line analogue in cephalopods: water waves generate microphonic potentials in the epidermal head lines of Sepia and...
Many cephalopods have lines of ciliated cells on their head and arms. In the cuttlefish Sepia and the squid Lolliguncula, electrophysiological recordings clearly identify these epidermal lines as an...
A string instrument pickup system sensitive to 360 of transverse string movement, which is substantially immune from microphonics, and which has a substantially equal or balanced response to all of the strings. In one form of the invention a piezoelectric transducer is compressively associated with vertical movement components of each string of the instrument, but is laterally offset from a centered position under the string for compressive association of the transducer also with the horizontal string movement components; and halves of the total piezoelectric transducer area are oppositely polarized so as to cancel out microphonics. In a modular form of the invention a plurality of the piezoelectric transducers are supported in an elongated array by means of a flexible body of electrically insulative material and a pliable outer wrapping of metal foil so that the transducer is conformable to distortions and deformations in string saddle and bridge elements of the instrument between which the modular
Mice homozygous for the jerker spontaneous mutation (|i|Espn|sup|je|/sup||/i|) show behavior typical of the circling mutants - head-tossing, circling, and hyperactivity. Homozygous mutant mice are deaf from birth and have no detectable stimulus-related cochlear potential at any stage. The abnormal behavior and deafness are associated with postnatal degeneration of the sensory cells of the cochlea and the sacculus and utriculus in homozygotes. The primary influence of the jerker gene appears to be on the apical hair cells, not development of neural structures. Heterozygous jerker mice undergo a similar type of degeneration, but the onset is delayed. Auditory brainstem response is totally absent in homozygotes while heterozygous mice undergo a progressive impairment with age.|br||br|Flexed tail homozygotes can be identified hematologically as earlyas embryonic day 13 and are detectably paler than normal by embryonic day 16, with most paler than normal by embryonic day 15. Homozygotes are small at birth
Canton has recently introduced eight new loudspeakers in its Ergo line, including a new powered subwoofer and seven full-range models featuring new crossover. New models include a trio of three-way floorstanders, two bookshelf speakers, two 2-1/2-way center channel speakers, and a 200-Watt powered subwoofer, and all are available in silver lacquer, black, beech, and cherry wood veneer finishes. The new Ergo full-range models incorporate improved crossover networks that are based on technology developed for the companys signature Karat Reference 2 DC loudspeaker system. These changes include the use of ICW polypropylene capacitors, which have led to a marked reduction in dielectric absorption or "memory" effects giving the models improved transient response and detail. The new crossover design also has a significant reduction in microphonics designed to improve mid-range and high-frequency reproduction. The new Ergo center channel speakers are 2-1/2-way designs optimized for horizontal mounting. ...
Subject: biophysics of infrasound From: Eliot Handelman ,eliot(at)SUNRISE.CC.MCGILL.CA, Date: Thu, 27 Jan 1994 17:19:34 EST Greetings, Im trying to locate research on the biophysical effects of infrasound. A few years ago I collected a series of citations -- about 25? from JASA, primarily from the late 50s and early 60s. Princeton cataloged several of these but they were all missing. It turned out that these papers were reclassified during 80s, and my efforts to get them through the DoD met with no success, supposedly because Princeton did not wish to comply with Dods restricted materials protocol. Can anyone tell me what is so interesting about biophysical effects of infrasound that merits classification? Best, -- eliot ...
Starting in 2011, infrasound sensors became a standard component and were installed at each new USArray Transportable Array (TA) site. Currently, with over 400 sensors, TA acts as a large infrasound array that continuously samples the wavefield of atmospheric acoustic sources. To support this new data set, the IRIS Data Management Center (DMC) has developed two infrasound data products: the TA Infrasound Reference Event Database (TAIRED) and TA Infrasound Detections (TAID). These two data products are designed to provide insight and tools for researchers to begin working with this large, and somewhat unique, new data set.. TAIRED (http://www.iris.edu/spud/infrasoundevent) is a user-supported evolving infrasound reference event depository where researchers can contribute to and find infrasound events for their research. This database currently holds 59 events including one meteorite, seven explosions, and 12 rocket launches. For each event, metadata, infrasound and seismic record sections, ...
Immunological identification of an inward rectifier K+ channel (Kir4.1) in the intermediate cell (melanocyte) of the cochlear...
The cochlear stria vascularis produces the positive endocochlear potential (EP) and the endolymph. Both the EP and the endolymph are essential for the physiological function of hair cells. The interme
Selective and Reversible Blocking of the Lateral Line in Freshwater Fish | Journal of Experimental Biology
Fish possess two separate systems for detection of low-level sound and water motions in the low-frequency range: the inner ear and the lateral line. The relative roles of these systems in normal fish behaviour is still not clear. There is, for instance, a lack of experimental evidence showing the involvement of the lateral line and the inner ear in detection of infrasound, in directional hearing in the near field, and in detection and attack of swimming prey below the surface. To provide a useful tool for such studies, we have developed a pharmacological method for selective and reversible blocking of the lateral line in the roach (Rutilus rutilus). By recording multi-unit activity from the lateral line nerve and microphonic potentials from the inner ear, we have shown that cobalt ions in the external water may completely block the mechanosensitivity of the lateral line without affecting the utricular microphonic activity. This inhibiting effect of Co2+ is antagonized by Ca2+, making the ratio ...
Synonyms for Acoustic reflex in Free Thesaurus. Antonyms for Acoustic reflex. 26 synonyms for reflex: automatic, spontaneous, instinctive, involuntary, impulsive, knee-jerk, unthinking, automatic, impulsive, instinctive, involuntary.... What are synonyms for Acoustic reflex?
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Select-A-Strike clappers are adjustable by rotating the clapper screw slightly counter-clockwise until the clapper is free to rotate. Rotate the clapper to the desired position and retighten the screw.. Quick-Adjust clappers (See Fig. 3) are adjustable without loosening the clapper screw. In fact, the clapper screw should never be turned. This screw is locked to the clapper shaft by a special chemical bond between the screw and shaft. To adjust, rotate clapper until it clicks into the desired position. NOTE: DO NOT TAKE YOUR QUICK-ADJUST CLAPPER APART. THEY MUST BE RETURNED TO THE FACTORY FOR ANY REPAIRS NEEDED.. Try it! On all bells C8 and below in pitch, three decidedly different impact tones can be achieved. This permits a selection of mellow or more brilliant tones to be generated in your bells, according to your tonal preference. These options provide a soft mellow strike tone designated by the letter S imprinted on the clapper insert, a medium tone designated by M on the insert, and ...
Below about 50 kHz the level of ambient noise in the sea increases continuously towards lower frequencies. In the infrasound range the spectral slope is particularly steep. This low-frequency noise may propagate long distances with little attenuation, causing a directional pattern of infrasound in the sea. Using a standing-wave acoustic tube, we have studied the sensitivity of cod to infrasound down to 0.1 Hz by means of the cardiac conditioning technique. The threshold values, measured as particle acceleration, showed a steady decline towards lower frequencies below 10 Hz, reaching a value close to 10(−5)ms-2 at 0.1 Hz. The spectrum level at 0.1 Hz in the sea ranges between 120 and 180 dB (re 1 microPa), with corresponding particle accelerations from less than 10(−6) to more than 10(−4)ms-2. The sensitivity of cod is thus sufficient to detect the highest levels of ambient infrasound, and we put forward the hypothesis that fish may utilize information about the infrasound pattern in the ...
Definition of acoustic reflex threshold in the Financial Dictionary - by Free online English dictionary and encyclopedia. What is acoustic reflex threshold? Meaning of acoustic reflex threshold as a finance term. What does acoustic reflex threshold mean in finance?
TY - JOUR. T1 - Intracellular Potential Changes of Cortis Organ With Anoxia. AU - Nuttall, Alfred L.. AU - Lawrence, Merle. PY - 1979/10. Y1 - 1979/10. N2 - Intracellular measurements of the resting cell membrane potentials of guinea pig Cortis organ were made in order to determine the sensitivity of this cell potential to anoxic hypoxia (a lowered oxygen state due to lack of respiratory oxygen) and to establish differences according to cell types or morphologic regions of the sensory epithelium. The negative cell potentials measured from successful electrode penetrations were found to be relatively more stable and resistant to change during a 120-s period of anoxia than was the positive endocochlear potential. The intracellular resting potentials were also much slower to recover after resumption of respiration. Data obtained from various cells in two different regions of Cortis organ indicate that Cortis organ is receiving oxygen from both the perilymph and the endolymph. An iontophoretic ...
Auditory evoked potentials (AEP) are highly demanded during the whole process of equipping patients with cochlear implants (CI). They play an essential role in preoperative diagnostics, intraoperative testing, and postoperative monitoring of auditory performance and success. The versatility of AEPs is essentially enhanced by their property to be evokable by acoustic as well as electric stimuli. Thus, the electric responses of the auditory system following acoustic stimulation and recorded by the conventional surface technique as well as by transtympanic derivation from the promontory (Electrocochleography [ECochG]) are used for the quantitative determination of hearing loss and, additionally, electrically evoked compound actions potentials (ECAP) can be recorded with the intracochlear electrodes of the implant just adjacent to the stimulation electrode to check the functional integrity of the device and its coupling to the auditory system ...
The MS4630B is suitable for electronics production lines demanding fast and accurate device measurements. It is particularly well suited to accurate, high-speed evaluation of IF filter resonance and group delay characteristics, among others.
A feverish quest exists to uncover the events that lead to cochlear amplification in mammals. The role of the OHC is certainly paramount, and we now have identified many componentsthat form the basis of the cells unique contribution. In my mind, a few observations leadthe story on this hot topic, including the molecular identification of the OHC motor, its modulation by anions and the demonstration of the motors anion transport capabilities. Here I review some of this recent work.. ...
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Plants to 1.5 cm high, in hoary green to gray-green cushions, opaque-green to nearly black below. Leaves loosely imbricate when dry, loosely erect-spreading when moist, somewhat concave but not at all keeled, to 3 mm long with the awn constituting nearly 1/2 of that length, ovate-lanceolate from a loosely sheathing somewhat expanded base, 2.5-3.5: 1. Median leaf cells in regular longitudinal rows, unistratose in the expanded base but uniformly bistratose in the limb, smooth, to 7 µm wide, isodiametric with lumens irregular but without corner thickenings. Marginal cells not differentiated. Basal juxtacostal cells elliptical, to 3: 1, to 15 µm wide, with irregularly thickened lateral walls. Basal marginal cells transversely elongate, 0.5-0.7: 1, to 15 µm wide. Costa flared at the base and filling 1/3-1/4 of immediate leaf base, narrowed and obscure above, percurrent in the somewhat acuminate awn. Costa cross-section at leaf middle broad and flattened, less than 1.5 times as thick as the ...
Identifying components of the hair-cell interactome involved in cochlear amplification | BMC Genomics | Full Text
Although outer hair cells (OHCs) play a key role in cochlear amplification, it is not fully understood how they amplify sound signals by more than 100 fold. Two competing or possibly complementary mechanisms, stereocilia-based and somatic electromotility-based amplification, have been considered. Lacking knowledge about the exceptionally rich protein networks in the OHC plasma membrane, as well as related protein-protein interactions, limits our understanding of cochlear function. Therefore, we focused on finding protein partners for two important membrane proteins: Cadherin 23 (cdh23) and prestin. Cdh23 is one of the tip-link proteins involved in transducer function, a key component of mechanoelectrical transduction and stereocilia-based amplification. Prestin is a basolateral membrane protein responsible for OHC somatic electromotility. Using the membrane-based yeast two-hybrid system to screen a newly built cDNA library made predominantly from OHCs, we identified two completely different groups of
18 yrs old Female asked about Auditory neuropathy, 1 doctor answered this and 67 people found it useful. Get your query answered 24*7 only on | Practo Consult
Impaired stria vascularis integrity upon loss of E cadherin in basal cells at eagle-i Network Shared Resource Repository
Impaired stria vascularis integrity upon loss of E cadherin in basal cells is an eagle-i resource of type Journal article at eagle-i Network Shared Resource Repository.
Grant finansowany przez: The J. William Fulbright Foreign Scholarship Board & The U.S. Department of State Nr P008/00 (2000-2001) - Kierownik Projektu i Główny Wykonawca "Identifying in an Animal Model Criteria for the Intraoperative Monitoring of Cochlear Function During Neuro-Otologic Surgery in Patients with Cerebello-Pontine Angle Tumors Using Otoacoustic Emissions ...
differences in human TM waves relative to those of other mammals.. TM wave properties were measured in samples taken from human cadavers ...
Can. J. Bot. 44: 609. 1966. -- Merceya latifoia Kindb. in Mac., Bull. Torr. Bot. Club 16: 94. 1889. -- Scopelophila latifolia (Kindb.) Ren. & Card., Rev. Bryol. 19: 92. 1892. Plants in thick turfs or as scattered tufts to 2.5 cm high, dark-green mostly with a reddish-brown cast. Leaves in a comose apical cluster, spreading when moist but keeled along costa and loosely reflexed near margins when dry, obovate to spatulate, 3.5-4.5 mm long, about 2.5: 1. Median laminal cells pluripapillose with low and inconspicuous punctiform papillae, to 16 µm broad, in straight rows radiating from costa to leaf margin, with lumen/wall ratio 4-8: 1, quadrate to hexagonal with angular lumens and without corner thickenings. Basal juxtacostal cells rectangular with straight and thin lateral walls, to 30 µm broad, 2-5: 1, smooth. Marginal cells abruptly larger than median cells, about twice as deep as wide, mostly reddish pigmented, less papillose and thicker-walled than adjacent laminal cells. Basal marginal cells ...
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Auditory Neuropathy, Autosomal Dominant 1 | definition of Auditory Neuropathy, Autosomal Dominant 1 by Medical dictionary
Looking for online definition of Auditory Neuropathy, Autosomal Dominant 1 in the Medical Dictionary? Auditory Neuropathy, Autosomal Dominant 1 explanation free. What is Auditory Neuropathy, Autosomal Dominant 1? Meaning of Auditory Neuropathy, Autosomal Dominant 1 medical term. What does Auditory Neuropathy, Autosomal Dominant 1 mean?
Auditory neuropathy is diagnosed when person has normal OAE reading but absent or abnormal Auditory Br ainstem Response. Therefore from OAE and ABR results indicated that hair cell of cochlear is intact but the transmission of auditory nerve to brain is impaired.. Treatment and intervention for auditory neuropathy. There are a few treatment and intervention options for Auditory Neuropathy. However the potential benefit of treatment and intervention are vary to individual.. Frequency modulation (FM) systems. Some professionals reported frequency modulation (FM) systems are helpful for auditory neuropathy with normal hearing. Frequency modulation (FM) system is a device that can transmit sound directly to the listener by sound wave. By using FM system, the listener could concentrate to the speech better and would be useful especially in noisy environment.. ...
Evaluation of hearing and cochlear function by audiometric testing in patients with hyperemesis gravidarum
INTRODUCTION: the aim of this study was to investigate cochlear functions in patients with hyperemesis gravidarum (HG). METHODES: twenty-nine HG patients (58 ears) and 31 healthy control subjects (62 ears) were included. Audiometry testings at 250 and 500 Hz and 1, 2, 4, 8, 10, 12, 14, 16 kHz were performed to the patients and controls. RESULTS: mean age of patients with HG was 26,5 4,4 years and the mean age of control group was 28,0 4,2 years. At the time of the tests mean gestational age of the HG group and controls were 9 and 11 weeks respectively. No differences were observed between the groups in tympanic membrane status, orother otolaringological evaluations. No significant differences were observed in audiometric tests at any frequencies between the groups (p values for all>0.05). CONCLUSION: there was not a difference between pregnant cases with HG and cases with normal pregnancy in terms of audimetric tests. Cochlear functions are not affectedremarkably in women with HG.
Randomized, double-blind, placebo-controlled safety, pharmacokinetic, pharmacodynamic study of oral SPI-1005 in adults with Menieres disease. All subjects will undergo baseline audiometric testing and have their severity of sensorineural hearing loss, tinnitus and vertigo determined before the start of a 21-day course of treatment with SPI-1005 or placebo. During treatment with SPI-1005, and 7 days and 28 days following the cessation of SPI-1005, subjects will have their hearing loss, tinnitus and vertigo assessed. Additional testing including electrocochleography will be performed at baseline, at the end of SPI-1005 treatment, and 28 days after the SPI-1005 treatment has stopped. Six outpatient visits will be performed over a 7-week period ...
Learn more about Auditory Neuropathy at TriStar Southern Hills DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ...
Learn more about Auditory Neuropathy at Doctors Hospital of Augusta DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ...
The mechanical waveform of the basilar membrane. II. From data to models--and back. - Semantic Scholar
Mechanical responses in the basal turn of the guinea-pig cochlea are measured with low-level broad-band noise as the acoustical stimulus [for details see de Boer and Nuttall, J. Acoust. Soc. Am. 101, 3583-3592 (1997)]. Results are interpreted within the framework of a classical three-dimensional model of the cochlea that belongs to a very wide class of nonlinear models. The use of linear-systems analysis for this class of nonlinear models has been justified earlier [de Boer, Audit. Neurosci. 3, 377-388 (1997)]. The data are subjected to inverse analysis with the aim to recover the effective basilar-membrane impedance. This is a parameter function that, when inserted into the model, produces a model response, the resynthesized response, that is similar to the measured response. With present-day solution methods, resynthesis leads back to an almost perfect replica of the original response in the spatial domain. It is demonstrated in this paper that this also applies to the response in the frequency
(article taken from empresschinchilla.com) Chinchilla, A Cellulose-Splitter Rodent Wendell Bird In the chinchillas native habitat, in which it has lived for many thousands of years, this animal has existed with a minimum of rainfall and other sources of water and has been able to thrive on relatively low protein fibers, dried grasses in a realtively…
Control of hearing sensitivity by tectorial membrane calcium | PNAS
D) Cochlear microphonic potential tuning curves at 64 dB SPL at the times corresponding to the images in A-C. Note the decrease ... CM, cochlear microphonic potential. (E-G) EGTA in the scala media had no effect on stereocilia morphology, except for a small ... I) Peak amplitude of the cochlear microphonic potential in the experiment shown in H. The vertical line at time 0 indicates the ... 4A, EGTA decreased the amplitude of the cochlear microphonic potential (compare center and top waveforms in Fig. 4A; the ...https://www.pnas.org/content/116/12/5756
Volume flow rate of perilymph in the guinea-pig cochlea.
Action Potentials. Animals. Cerebrospinal Fluid / physiology. Cochlea / physiology*. Cochlear Microphonic Potentials. Guinea ... This amount of TMPA had virtually no toxic effect on cochlear function. The spread of tracer by longitudinal volume flow and ... These findings support the concept that perilymph composition is maintained by local, cochlear mechanisms which do not involve ... probably as a result of cerebrospinal fluid entry through the cochlear aqueduct. When the cochlea was sealed (with recording ...http://www.biomedsearch.com/nih/Volume-flow-rate-perilymph-in/3198505.html
Single-neuron labeling and chronic cochlear pathology. IV. Stereocilia damage and alterations in rate- and phase-level...
Cochlear Microphonic Potentials. Hair Cells, Auditory / physiopathology*. Hair Cells, Auditory, Inner / physiopathology. ... Previous Document: Single-neuron labeling and chronic cochlear pathology. III. Stereocilia damage and alterations of th.... ... Single-neuron labeling and chronic cochlear pathology. IV. Stereocilia damage and alterations in rate- and phase-level ...http://www.biomedsearch.com/nih/Single-neuron-labeling-chronic-cochlear/6511674.html
Neural responses to one- and two-tone stimuli in the hearing organ of the dengue vector mosquito | Journal of Experimental...
1982). Cochlear microphonic potentials elicited by biosonar signals in flying bats, Pteronotus p. parnellii. Hearing Res. 7, ... Termed the summating potential and cochlear microphonic, respectively, they arise from direct and alternating transduction ... 1986). Phase-locking in the cochlear nerve of the guinea-pig and its relation to the receptor potential of inner hair cells. ... A) Averaged field potentials recorded in response to 500 and 540 Hz tones presented separately at 90 dB in one male (blue). ...https://jeb.biologists.org/content/213/8/1376?ijkey=923b9b8d6028c12d8ab2e812823357187b4b58b4&keytype2=tf_ipsecsha
Find Research Outputs - Northwestern Scholars
Production of cochlear potentials by inner and outer hair cells. Dallos, P. & Cheatham, M. A., Jan 1 1976, In : journal of the ... Re-examination of avian cochlear potentials. Pierson, M. & Dallos, P., Dec 1 1976, In : Nature. 262, 5569, p. 599-601 3 p.. ...https://www.scholars.northwestern.edu/en/publications/?format=&page=4613
Effects of salicylate on sound-evoked outer hair cell stereocilia deflections
However, when prestin activity was altered with the chloride ionophore tributyltin, both the cochlear microphonic potential and ... Surprisingly, following application of salicylate, outer hair cell stereocilia deflections increased, while cochlear ... indicating that the observed effects did not depend on the endocochlear potential. These data suggest that salicylate may alter ... time-resolved confocal imaging to visualize outer hair cell stereocilia during sound stimulation in the apical turn of cochlear ...http://liu.diva-portal.org/smash/record.jsf?pid=diva2:763057
Audiology and Neurotology
The cochlear microphonic potential (CM) from the basal cochlea was monitored by a round-window electrode. In 13 of the 20 ... The cochlear microphonic potential (CM) from the basal cochlea was monitored by a round-window electrode. In 13 of the 20 ... The Crista Fenestra and Its Impact on the Surgical Approach to the Scala Tympani during Cochlear Implantation. Conclusion: The ... Histopathology of the Human Inner Ear in the Cogan Syndrome with Cochlear Implantation. The Cogan syndrome is a rare disorder ...https://medworm.com/journal/audiology-and-neurotology/
Find Research Outputs - Northwestern Scholars
Cochlear potentials: A status report. Dallos, P., Jan 1 1972, In : International Journal of Audiology. 11, 1-2, p. 29-41 13 p. ... Cochlear summating potentials. Descriptive aspects.. Dallos, P., Schoeny, Z. G. & Cheatham, M. A., Dec 1 1972, In : Acta Oto- ... Cochlear inner and outer hair cells: Functional differences. Dallos, P., Billone, M. C., Durrant, J. D., Wang, C. Y. & Raynor, ...https://www.scholars.northwestern.edu/en/publications/?format=&page=4392
PubMed medline query
In all the experimental conditions, no effect was observed on the cochlear microphonic potential. This observation is ... A further slight N-methyl-D-aspartate-induced decrease of the amplitude of the compound action potential, although non ... a significant reduction of the amplitude of the compound action potential and an increase of the N1 latency, both predominant ...http://www.neuroreille.com/promenade/biblio/Medline/Innerv_puel2.htm
Persistent Auditory Nerve Damage Following Kainic Acid Excitotoxicity in the Budgerigar ( Melopsittacus undulatus) |...
auditory brainstem response central gain cochlear microphonic compound action potential This is a preview of subscription ... Acute KA effects on cochlear function were assessed using AN compound action potentials (CAPs) and hair cell cochlear ... Bledsoe SC, Bobbin RP, Chihal DM (1981) Kainic acid: an evaluation of its action on cochlear potentials. Hear Res 4:109-120 ... Gu JW, Herrmann BS, Levine RA, Melcher JR (2012) Brainstem auditory evoked potentials suggest a role for the ventral cochlear ...https://link.springer.com/article/10.1007%2Fs10162-018-0671-y
Electrophysiology Archives - Pathways Society
The cochlear potentials include the cochlear microphonic (CM)…. Read More. 2019-01-16. ... has been employed to assess stimulus-related cochlear potentials and the compound action potential (AP) of the auditory nerve. ... Can Cortical Auditory Evoked Potentials Demonstrate An Electrophysiological Release From Masking In Noise?. February 6, 2019. ... This Pathways article will focus on an auditory evoked potential (AEP) that should be considered more than it has been - ...https://hearinghealthmatters.org/pathways/clinical-applications/electrophysiology-clinical-applications/
Z ^ b ^
Discuss the cochlear microphonic potential. 2010 May 1) a. Discuss the renal plasma clearance concept and explain why the ... the sequence of events that occur between entry of sound wave into the ear and the firing of action potentials in the cochlear ... Describe the " Cochlear pathway " . 31. Draw a labeled section in mid-brain at the level of inferior colliculus. 32. Describe ... occurs between the entry of sound wave into the external auditory canal and the firing of action potentials in the cochlear ...http://spotidoc.com/doc/707718/z-%5E-_-b-%5E
Kenneth Johnson, Ph.D.
Surprisingly, otoacoustic emissions and cochlear microphonic potentials, which reflect cochlear outer hair cell (OHC) function ... were largely unaffected in mutant mice, whereas auditory brainstem responses and the compound action potential were grossly ...https://www.jax.org/research-and-faculty/faculty/kenneth-johnson
LILACS - Resultado p gina 1
... such as the cochlear microphonic potential and the compound action potential of the auditory nerve. However, some years ago, it ... Analysis of electrically evoked compound action potential of the auditory nerve in children with bilateral cochlear implants / ... it has been known that placing an electrode near the round window niche allows the recording of cochlear potentials in response ... The cochlear implant device has the capacity to measure the electrically evoked compound action potential of the auditory nerve ...http://bases.bireme.br/cgi-bin/wxislind.exe/iah/online/?IsisScript=iah/iah.xis&nextAction=lnk&base=LILACS&lang=p&format=detailed.pft&indexSearch=EX&exprSearch=G04.580.100
Hereditary motor and sensory neuropathy Lom type in a Serbian family
... a positive correlation of otoacoustic emission was found as well as evidence of cochlear microphonic potentials, which are ... 1. Butinar D, Starr A, Vatovec J. Brainstem auditory evoked potentials and cochlear microphonics in the HMSN family with ... Brainstem auditory evoked potentials did not contain neural component (2).. Eight to ten million Gypsies who live in Europe ... Hearing loss of our patients was caused by an auditory nerve dysfunction in the presence of preserved cochlear outer hear cell ...http://pubmedcentralcanada.ca/pmcc/articles/PMC2858934/
Responses from the hair cells are the cochlear microphonic (CM) and summating potential (SP). Responses from the auditory nerve ... In the ongoing response to tones, the ECoG contains both the cochlear microphonic (CM) and auditory nerve neurophonic (ANN) ... Each electrode was analyzed quantitatively using impedance and sound-induced cochlear microphonic (CM) recordings in gerbil ... A cochlear implant is a medical device which directly stimulates cochlear neurons in response to auditory stimuli, assisting in ...http://www.med.unc.edu/dms/Fax-journal/2012-2013-edition
List of MeSH codes (G11) - Wikipedia
... cochlear microphonic potentials MeSH G11.561.250.370.300 --- evoked potentials, auditory, brain stem MeSH G11.561.250.385 --- ... evoked potentials, motor MeSH G11.561.250.400 --- evoked potentials, somatosensory MeSH G11.561.250.425 --- evoked potentials, ... event-related potentials, p300 MeSH G11.561.250.370 --- evoked potentials, auditory MeSH G11.561.250.370.223 --- ... visual MeSH G11.561.250.440 --- excitatory postsynaptic potentials MeSH G11.561.450.100 --- action potentials MeSH G11.561. ...https://en.wikipedia.org/wiki/List_of_MeSH_codes_(G11)
Hearing | Encyclopedia.com
Electrical potentials. Many of the mechanical events just described have an electrical counter part. The cochlear micro-phonic, ... Waltzman, S.; Cohen, N.; and Shapiro, B. "The Benefits of Cochlear Implantation in the Geriatric Population." Otolaryngology- ... These individuals are potential candidates for a cochlear implant, a surgically implanted device that delivers speech signals ... an electrical potential derived from the cochlea, reflects the displacement of the basilar membrane. The endocochlear potential ...https://www.encyclopedia.com/medicine/anatomy-and-physiology/anatomy-and-physiology/hearing
NIOSHTIC-2 Search Results - Full View
Interactions with noise on cochlear potentials, namely compound action potential (CAP) and cochlear microphonic (CM) were ...http://www2a.cdc.gov/nioshtic-2/BuildQyr.asp?s1=temporary&f1=%2A&Startyear=&Adv=0&terms=1&EndYear=&Limit=10000&sort=&D1=10&PageNo=31&RecNo=301&View=f&
NIOSHTIC-2 Search Results - Full View
Interactions with noise on cochlear potentials, namely compound action potential (CAP) and cochlear microphonic (CM) were ...http://www2.cdc.gov/nioshtic-2/BuildQyr.asp?s1=noise%2A&f1=%2A&s2=&PageNo=151&RecNo=1506&View=f&
NIOSHTIC-2 Search Results - Full View
Interactions with noise on cochlear potentials, namely compound action potential (CAP) and cochlear microphonic (CM) were ...http://www2.cdc.gov/nioshtic-2/BuildQyr.asp?s1=%27hearing+loss%27&f1=%2A&Startyear=&t1=0&s2=noise%2A&terms=3&Adv=1&ct=&B1=Search&f2=%2A&Limit=500&Sort=DP+DESC&D1=10&EndYear=&PageNo=94&RecNo=934&View=f&
Ichiji Tasaki, MD - Basser Lab: Section on Quantitative Imaging and Tissue Sciences - [email protected]
Tasaki, I. and Fernandez, C. Effect of direct current upon the cochlear microphonic and action potential of the guinea pig. ... Tasaki, I., Davis, H., and Legouix, J.P. The space-time patterns of the cochlear microphonic in guinea pig. In 43rd Meeting of ... Tasaki, I., Davis, H., and Eldridge, D.H. Exploration of cochlear potentials in guinea pig with a microelectrode. J Acous Soc ... Fernández, C., Butler, R., Konishi, T., Honrubia, V, and Tasaki, I. Cochlear potentials in the Rhesus and squirrel monkey. J. ...https://science.nichd.nih.gov/confluence/display/sqits/Ichiji+Tasaki%2C+MD
Diseases of Ear, Nose and Throat & Head and Neck Surgery | P L Dhingra, Shruti Dhingra | download
They are: 1. 2. 3. 4. Endocochlear potential Cochlear microphonic Summating potential Compound action potential from cochlea ... The response is in the form of three phenomena: cochlear microphonics, summating potentials and the action potential of VIIIth ... It is an alternating current (AC) potential. 3. Summating Potential (SP). It is a DC potential and follows "envelope" of ... 2. Cochlear Microphonic (CM). When basilar membrane moves in response to sound stimulus, electrical resistance at the tips of ...https://b-ok.org/book/3651960/c76516
Henson OW, Pollak GD, Kobler JB, Henson MM, Goldman LJ (1982) Cochlear microphonic potentials elicited by biosonar signals in ... Suga N (1969b) Echo-location and evoked potentials of bats after ablation of inferior colliculus. J Physiol 203:707-728. pmid: ... Lewicki MS (1998) A review of methods for spike sorting: the detection and classification of neural action potentials. Network ... Alternating gray scales visualize which action potentials were evoked by which call-echo element. B, Neuronal response from a ...http://www.eneuro.org/content/4/6/ENEURO.0314-17.2017
Three-dimensional current flow in a large-scale model of the cochlea and the mechanism of amplification of sound | Journal of...
This is in agreement with the measurements of the cochlear microphonic (CM), an extracellular potential arising from sound ... 2005). (c) The time course of the IHC receptor potential (the node 2, , in figure 1b) along the cochlear axis in response to a ... 1973 A quantitative study of cochlear potentials along the scala media of the guinea pig. J. Acoust. Soc. Am. 54, 600-609. doi: ... 1986 Phase-locking in the cochlear nerve of the guinea-pig and its relation to the receptor potential of inner hair-cells. Hear ...http://rsif.royalsocietypublishing.org/content/6/32/279
- Our results show that, when N-methyl-D-aspartate and the antagonist 2-amino-5-phosphonovalerate are perfused through the perilymphatic scalae, they induced, by different mechanisms, a significant reduction of the amplitude of the compound action potential and an increase of the N1 latency, both predominant at high intensity tone burst stimulations. (neuroreille.com)
- A further slight N-methyl-D-aspartate-induced decrease of the amplitude of the compound action potential, although non significant, was observed when the Mg2(+)-free perilymph contained 100 or 1000 microM glycine. (neuroreille.com)
- Andrew Stuart1 & Alyson Butler Lake2 1Department of Communication Sciences & Disorders, East Carolina University, Greenville, NC 2Blue Ridge Ear, Nose, Throat & Plastic Surgery, Lynchburg, VA Electrocochleography (ECochG) has been employed to assess stimulus-related cochlear potentials and the compound action potential (AP) of the auditory nerve. (hearinghealthmatters.org)
- Surprisingly, otoacoustic emissions and cochlear microphonic potentials, which reflect cochlear outer hair cell (OHC) function, were largely unaffected in mutant mice, whereas auditory brainstem responses and the compound action potential were grossly abnormal. (jax.org)
- Interactions with noise on cochlear potentials, namely compound action potential (CAP) and cochlear microphonic (CM) were studied. (cdc.gov)
- In the majority of OTOF children, the SP component is followed by a markedly prolonged low-amplitude negative potential replacing the compound action potential (CAP) recorded in normally-hearing children. (ovid.com)
- The cochlear microphonic potential (CM) from the basal cochlea was monitored by a round-window electrode. (medworm.com)
- Demonstration of traveling waves in the guinea pig cochlea by recording cochlear microphonics. (nih.gov)
- For many years, cochlear fluids were thought to be generated by filtration of blood or cerebrospinal fluid, which then flowed longitudinally down the length of the cochlea to be absorbed through the endolymphatic sac. (medscape.com)
- Transtympanic electrocochleography (ECochG) has recently been proposed for defining the details of potentials arising in both the cochlea and auditory nerve in this disorder, and with a view to shedding light on the pathophysiological mechanisms underlying auditory dysfunction. (ovid.com)
- Sensorineural hearing loss was confirmed on electrocochleography and brainstem evoked potentials. (pubmedcentralcanada.ca)
- Electrocochleography (ECoG) responses from the round window to acoustic stimuli can characterize the condition of hair cells and auditory nerve fibers in patients receiving cochlear implants. (unc.edu)
- We used two- and three-dimensional time-resolved confocal imaging to visualize outer hair cell stereocilia during sound stimulation in the apical turn of cochlear explant preparations from the guinea pig. (diva-portal.org)
- Surprisingly, following application of salicylate, outer hair cell stereocilia deflections increased, while cochlear microphonic potentials decreased. (diva-portal.org)
- However, when prestin activity was altered with the chloride ionophore tributyltin, both the cochlear microphonic potential and the stereocilia deflection amplitude decreased. (diva-portal.org)
- The critical structure involved in this transduction process is the organ of Corti, an array of sensory and non-sensory cells located along the basilar membrane (BM), a dividing partition of the cochlear duct. (royalsocietypublishing.org)
- At intensities below about 60 dB an active process, the 'cochlear amplifier' (CA), somehow provides additional energy that enhances the vibration of a narrow segment of the basilar membrane near the apical foot of the familiar, traveling wave envelope. (nih.gov)
- It is unclear whether cochlear amplification arises uniquely from a voltage-dependent mechanism (electromotility) associated with outer hair cells (OHCs) or whether other mechanisms are necessary, for the voltage response of OHCs is apparently attenuated excessively by the membrane electrical filter. (royalsocietypublishing.org)
- We show that cochlear microphonic (CM) amplitude and summating potential (SP) amplitude and latency are normal, consistently with a preserved outer and inner hair cell function. (ovid.com)
- Monitoring device use in cochlear implant recipients of all ages provides important information about the listening conditions encountered in recipients' daily lives that may support counseling and assist in the further management of their device settings. (medworm.com)
- ECoG recordings in cochlear implant patients can provide important predictive information regarding speech perception outcomes. (unc.edu)
- The CA model explains the detection of small differences in time as well as in frequency, the dual character of the electrocochleogram, recruitment of loudness in cochlear hearing impairment, the long latency of normal neural responses near threshold, acoustic emissions (both stimulated and spontaneous) and the locus of TTS in the frequency range above the exposure tone. (nih.gov)
- Changes in the resting open probability alter the amplitude of the "silent current" ( 4 , 5 ) that continuously flows into the sensory cells, causing them to operate at a relatively depolarized membrane potential near −40 mV ( 6 ). (pnas.org)
- Stimulation at high rates reduces the amplitude and duration of the prolonged potentials, consistently with their neural generation. (ovid.com)
- Responses from the hair cells are the cochlear microphonic (CM) and summating potential (SP). (unc.edu)
- We have included experimentally determined parameters of cochlear macromechanics, which govern sound transduction, and data on hair cells' electrical parameters including tonotopical variation in the membrane conductance of OHCs. (royalsocietypublishing.org)
- b )(i) Equivalent electrical circuit of a single hair cell and (ii) a cochlear cross section from ( a ). (royalsocietypublishing.org)
- Field potentials from sound-transducing neurons in the antennae contain both sustained and oscillatory components to pure and paired tone stimuli. (biologists.org)
- Bharadwaj HM, Verhulst S, Shaheen L, Liberman MC, Shinn-Cunningham BG (2014) Cochlear neuropathy and the coding of supra-threshold sound. (springer.com)
- It has long been known that the primary afferents therein are sensitive to pure tones near the fundamental frequency of the wing beats, with gross-evoked field potentials oscillating at twice the stimulus frequency (e.g. (biologists.org)
- ECoG potentials in response to tone bursts of varying frequency and intensity were recorded from the round window intraoperatively in pediatric and adult patients undergoing cochlear implantation. (unc.edu)