Pathological processes of the snail-like structure (COCHLEA) of the inner ear (LABYRINTH) which can involve its nervous tissue, blood vessels, or fluid (ENDOLYMPH).
Blockage of the RETINAL VEIN. Those at high risk for this condition include patients with HYPERTENSION; DIABETES MELLITUS; ATHEROSCLEROSIS; and other CARDIOVASCULAR DISEASES.
The original member of the family of endothelial cell growth factors referred to as VASCULAR ENDOTHELIAL GROWTH FACTORS. Vascular endothelial growth factor-A was originally isolated from tumor cells and referred to as "tumor angiogenesis factor" and "vascular permeability factor". Although expressed at high levels in certain tumor-derived cells it is produced by a wide variety of cell types. In addition to stimulating vascular growth and vascular permeability it may play a role in stimulating VASODILATION via NITRIC OXIDE-dependent pathways. Alternative splicing of the mRNA for vascular endothelial growth factor A results in several isoforms of the protein being produced.
The administration of substances into the VITREOUS BODY of the eye with a hypodermic syringe.
Fluid accumulation in the outer layer of the MACULA LUTEA that results from intraocular or systemic insults. It may develop in a diffuse pattern where the macula appears thickened or it may acquire the characteristic petaloid appearance referred to as cystoid macular edema. Although macular edema may be associated with various underlying conditions, it is most commonly seen following intraocular surgery, venous occlusive disease, DIABETIC RETINOPATHY, and posterior segment inflammatory disease. (From Survey of Ophthalmology 2004; 49(5) 470-90)
A surgical specialty concerned with the structure and function of the eye and the medical and surgical treatment of its defects and diseases.
Central retinal vein and its tributaries. It runs a short course within the optic nerve and then leaves and empties into the superior ophthalmic vein or cavernous sinus.
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.

3D MRI of the membranous labyrinth. An age related comparison of MR findings in patients with labyrinthine fibrosis and in persons without inner ear symptoms. (1/37)

PURPOSE: We compared MRI of the membranous labyrinth in patients with chronic non-neoplastic inner ear disease and MR signs of labyrinthine fibrosis and controls depending on their age, in order to establish whether there were any MR differences regarding patient age groups, control age groups and between the patients and controls themselves. MATERIALS AND METHODS: Clinical ENT examinations as well as a T2* weighted 3D CISS (Constructive Interference in Steady State) sequence with a slice thickness of 0.7 mm were performed. Our collective was subdivided as follows: 0-19 years (10 controls, 3 patients with chronic non-neoplastic inner ear disease), 20-49 years (55 controls, 8 patients), 50 years and older (40 controls, 22 patients). Detectability of labyrinthine structures (e.g. cochlea, vestibule, semicircular canals) and filling defects were evaluated. RESULTS: In the 3 age-groups of the control collective no significant differences were observed in the membranous labyrinth. However differences concerning labyrinthine detectability emerged between controls and patients in both the 20-49 years and 50 years and older age groups. In the patient collective the 3 age groups showed no significant discrepancy in the mean number of lesions. CONCLUSION: Filling defects of the membranous labyrinth on 3D CISS MR images are pathological even in older persons. We would therefore recommend high resolution T2* weighted MRI in the case of suspected labyrinthine fibrosis.  (+info)

Ototoxicity: an argument for evaluation of the cochlea in safety testing in animals. (2/37)

The cochlea is one of the more common targets for toxic effects, yet current toxicologic screening in animals does not routinely evaluate the cochlea as a potential target organ. Although histopathologic sections are routinely taken from the eye and the optic nerve and tract and most studies include at least 1 section through the nasal cavity and olfactory mucosa, the cochlea is not histopathologically examined in routine toxicity studies. Unfortunately, routine clinical examinations frequently miss ototoxicity because rodents and other species can lose most of their high-frequency hearing and still respond to most ambient noises. Ototoxicity as a deficiency in toxicologic screening can be remedied by using well-established histopathologic and behavioral methods or electrophysiologic methods, such as brain stem auditory evoked responses (BAERs). Once the equipment is in place, BAERs can be obtained quickly and easily for ototoxicity screening (approximately 15 minutes for paired testing of 2 rats and 30 minutes each for dogs). BAERs also can be used in virtually all mammalian species. Three or 4 probe frequencies (eg, 4, 8, 16, and 32 kHz), representing different areas of the cochlea, can be tested in a few minutes with subcutaneous electrodes under short-acting chemorestraint. Given the availability of several approaches to screening for ototoxicity and the importance of the auditory function in human health, safety tests of chemicals and drugs should include an effective screening test for ototoxicity.  (+info)

Spiral ligament pathology: a major aspect of age-related cochlear degeneration in C57BL/6 mice. (3/37)

Data from systematic, light microscopic examination of cochlear histopathology in an age-graded series of C57BL/6 mice (1.5-15 months) were compared with threshold elevations (measured by auditory brain stem response) to elucidate the functionally important structural changes underlying age-related hearing loss in this inbred strain. In addition to quantifying the degree and extent of hair cell and neuronal loss, all structures of the cochlear duct were qualitatively evaluated and any degenerative changes were quantified. Hair cell and neuronal loss patterns suggested two degenerative processes. In the basal half of the cochlea, inner and outer hair cell loss proceeded from base to apex with increasing age, and loss of cochlear neurons was consistent with degeneration occurring secondary to inner hair cell loss. In the apical half of the cochlea with advancing age, there was selective loss of outer hair cells which increased from the middle to the extreme apex. A similar gradient of ganglion cell loss was noted, characterized by widespread somatic aggregation and demyelination. In addition to these changes in hair cells and their innervation, there was widespread degeneration of fibrocytes in the spiral ligament, especially among the type IV cell class. The cell loss in the ligament preceded the loss of hair cells and/or neurons in both space and time suggesting that fibrocyte pathology may be a primary cause of the hearing loss and ultimate sensory cell degeneration in this mouse strain.  (+info)

Delayed inner ear maturation and neuronal loss in postnatal Igf-1-deficient mice. (4/37)

Insulin-like growth factor-1 (IGF-1) has been shown to play a key role during embryonic and postnatal development of the CNS, but its effect on a sensory organ has not been studied in vivo. Therefore, we examined cochlear growth, differentiation, and maturation in Igf-1 gene knock-out mice at postnatal days 5 (P5), P8, and P20 by using stereological methods and immunohistochemistry. Mutant mice showed reduction in size of the cochlea and cochlear ganglion. An immature tectorial membrane and a significant decrease in the number and size of auditory neurons were also evident at P20. IGF-1-deficient cochlear neurons showed increased caspase-3-mediated apoptosis, along with aberrant expression of the early neural markers nestin and Islet 1/2. Cochlear ganglion and fibers innervating the sensory cells of the organ of Corti presented decreased levels of neurofilament and myelin P(0) in P20 mouse mutants. In addition, an abnormal synaptophysin expression in the somata of cochlear ganglion neurons and sensory hair cells suggested the persistence of an immature pattern of synapses distribution in the organ of Corti of these animals. These results demonstrate that lack of IGF-1 in mice severely affects postnatal survival, differentiation, and maturation of the cochlear ganglion cells and causes abnormal innervation of the sensory cells in the organ of Corti.  (+info)

Dynamics of noise-induced cellular injury and repair in the mouse cochlea. (5/37)

To assess the dynamics of noise-induced tissue injury and repair, groups of CBA/CaJ mice were exposed to an octave-band noise for 2 hours at levels of 94, 100, 106, 112, or 116 dB SPL and evaluated at survival times of 0, 12, 24 hours or 1, 2, or 8 weeks. Functional change, assessed via auditory brainstem response (ABR), ranged from a reversible threshold shift (at 94 dB) to a profound permanent loss (at 116 dB). Light microscopic histopathology was assessed in serial thick plastic sections and involved quantitative evaluation of most major cell types within the cochlear duct, including hair cells (and their stereocilia), supporting cells, ganglion cells, spiral ligament fibrocytes, spiral limbus fibrocytes, and the stria vascularis. Morphometry allowed patterns of damage to be systematically assessed as functions of (1) cochlear location, (2) exposure level, and (3) postexposure survival. Insights into mechanisms of acute and chronic noise-induced cellular damage are discussed.  (+info)

Acrylonitrile produces transient cochlear function loss and potentiates permanent noise-induced hearing loss. (6/37)

There is growing evidence that agents that produce oxidative stress in the cochlea have significant ototoxic potential by themselves and can potentiate noise-induced hearing loss as well. Acrylonitrile (ACN) metabolism entails conjugation with glutathione, resulting in rapid and pronounced depletion of this important antioxidant in many organs including brain, liver, and kidney. ACN metabolism also results in cyanide (CN) formation through a secondary oxidative pathway. The results of two physiological experiments are reported here. First, the acute effects of ACN (50 mg/kg sc) on auditory sensitivity are assessed using a within subject study. In the second study, persistent effects of ACN alone (50 mg/kg, sc and 2 x 50 mg/kg, sc) and ACN in combination with noise exposure (8 h, 108 dB octave-band noise) are evaluated using threshold sensitivity as the dependent measure. Auditory threshold shift and absolute thresholds were determined using the compound action potential (CAP) amplitude. Acute ACN administration produces a loss in auditory threshold sensitivity that reached a maximum 10-20 min following sc injection. Auditory thresholds returned to control levels 75-100 min following exposure. In the study of permanent auditory threshold shifts, ACN plus noise increased auditory threshold impairment relative to rats receiving noise only when thresholds were assessed 3 weeks following exposure. ACN by itself did not produce permanent threshold impairment 3 weeks following administration. Assays were undertaken in separate groups of rats to track the elevation in blood CN and the depletion of total glutathione in cochlea, brain, and liver following ACN treatment. Systemic blood CN levels were not significantly elevated until 60-120 min following injection, and cochlear glutathione levels showed significant depletion as little as 15 min after injection and remained depressed for about 4 h. The results confirm the prediction that ACN is acutely ototoxic and can enhance noise-induced hearing loss.  (+info)

Myo15 function is distinct from Myo6, Myo7a and pirouette genes in development of cochlear stereocilia. (7/37)

The unconventional myosin genes Myo15, Myo6 and Myo7a are essential for hearing in both humans and mice. Despite the expression of each gene in multiple organs, mutations result in identifiable phenotypes only in auditory or ocular sensory organs. The pirouette (pi) mouse also exhibits deafness and an inner ear pathology resembling that of Myo15 mutant mice and thus may be functionally related to Myo15. In order to investigate possible interactions between Myo15 and Myo6, Myo7a, and the gene affected in pirouette, we crossed Myo15(sh2/sh2) mice to the three other mutant mouse strains. Hearing in doubly heterozygous mice was similar to age-matched singly heterozygous animals, indicating that partial deficiency for both Myo15 and one of these other deafness genes does not reduce hearing. Viable double mutants were obtained from each cross, indicating that potential overlapping functions between these genes in other organs are not essential for viability. All critical cell types of the cochlear sensory epithelium were present in double mutant mice and cochlear stereocilia exhibited a superimposition of single mutant phenotypes. These data suggest that the function of Myo15 is distinct from that of Myo6, Myo7a or pi in development and/or maintenance of stereocilia.  (+info)

Abnormal auditory brainstem responses and cochlear pathology in rats induced by an exaggerated styrene exposure regimen. (8/37)

Groups of 12 male 42-day-old rats were exposed to 0 or 800 ppm styrene vapors for 14 hr/day, 5 days/week for 3 weeks. Tone-pip auditory brainstem responses (ABRs) at 4, 8, 16, and 30 kHz were obtained after the last exposure. ABRs were minimally affected at 4 kHz and moderately to severely affected at 8, 16, and 30 kHz as indicated by waveforms which had a decreased amplitude and increased latency as compared to the controls. Missing outer hair cell(s) were evident in the basal and lower middle turns of the organ of Corti. Outer hair cell loss was least in the first row and greatest in the second and third rows. Occasional inner hair cells were also missing in regions of severe outer hair cell loss. The distribution of hair cell loss within the cochlea was consistent with the pattern of ABR alterations. These data document mid-frequency auditory dysfunction in styrene-exposed young adult rats with significant damage to the organ of Corti following an exaggerated styrene exposure regimen.  (+info)

Cochlear diseases refer to conditions that affect the structure or function of the cochlea, which is a part of the inner ear responsible for hearing. These diseases can cause various types and degrees of hearing loss, ranging from mild to profound. Some common cochlear diseases include:

1. Cochlear otosclerosis: A condition where there is abnormal bone growth in the cochlea, which can lead to conductive or sensorineural hearing loss.
2. Cochlear Meniere's disease: A disorder that affects the inner ear and causes vertigo, tinnitus, and fluctuating hearing loss.
3. Cochlear damage due to exposure to loud noises: Prolonged or sudden exposure to loud noises can cause permanent cochlear damage and hearing loss.
4. Presbycusis: Age-related hearing loss that affects the cochlea and other structures of the auditory system.
5. Cochlear nerve tumors: Rare benign or malignant growths on the cochlear nerve can cause hearing loss, tinnitus, and balance problems.
6. Infections: Bacterial or viral infections such as meningitis, labyrinthitis, or otitis media can damage the cochlea and lead to hearing loss.
7. Ototoxicity: Certain medications can be toxic to the cochlea and cause hearing loss, tinnitus, or balance problems.
8. Genetic factors: Inherited genetic mutations can cause various types of cochlear diseases, such as connexin 26 deficiency, Waardenburg syndrome, or Usher syndrome.

It is important to note that early diagnosis and treatment of cochlear diseases can help prevent or minimize hearing loss and other complications.

Retinal vein occlusion (RVO) is a medical condition that occurs when one of the retinal veins, which drains blood from the retina, becomes blocked by a blood clot or atherosclerotic plaque. This blockage can cause hemorrhages, fluid accumulation, and damage to the retinal tissue, leading to vision loss.

There are two types of RVO: branch retinal vein occlusion (BRVO) and central retinal vein occlusion (CRVO). BRVO affects a smaller branch retinal vein, while CRVO affects the main retinal vein. CRVO is generally associated with more severe vision loss than BRVO.

Risk factors for RVO include hypertension, diabetes, high cholesterol levels, smoking, and glaucoma. Age is also a significant risk factor, as RVO becomes more common with increasing age. Treatment options for RVO may include controlling underlying medical conditions, laser therapy, intravitreal injections of anti-VEGF agents or steroids, and surgery in some cases.

Vascular Endothelial Growth Factor A (VEGFA) is a specific isoform of the vascular endothelial growth factor (VEGF) family. It is a well-characterized signaling protein that plays a crucial role in angiogenesis, the process of new blood vessel formation from pre-existing vessels. VEGFA stimulates the proliferation and migration of endothelial cells, which line the interior surface of blood vessels, thereby contributing to the growth and development of new vasculature. This protein is essential for physiological processes such as embryonic development and wound healing, but it has also been implicated in various pathological conditions, including cancer, age-related macular degeneration, and diabetic retinopathy. The regulation of VEGFA expression and activity is critical to maintaining proper vascular function and homeostasis.

An intravitreal injection is a medical procedure in which medication is delivered directly into the vitreous cavity of the eye, which is the clear, gel-like substance that fills the space between the lens and the retina. This type of injection is typically used to treat various eye conditions such as age-related macular degeneration, diabetic retinopathy, retinal vein occlusion, and uveitis. The medication administered in intravitreal injections can help to reduce inflammation, inhibit the growth of new blood vessels, or prevent the formation of abnormal blood vessels in the eye.

Intravitreal injections are usually performed in an outpatient setting, and the procedure typically takes only a few minutes. Before the injection, the eye is numbed with anesthetic drops to minimize discomfort. The medication is then injected into the vitreous cavity using a small needle. After the injection, patients may experience some mild discomfort or a scratchy sensation in the eye, but this usually resolves within a few hours.

While intravitreal injections are generally safe, there are some potential risks and complications associated with the procedure, including infection, bleeding, retinal detachment, and increased intraocular pressure. Patients who undergo intravitreal injections should be closely monitored by their eye care provider to ensure that any complications are promptly identified and treated.

Macular edema is a medical condition characterized by the accumulation of fluid in the macula, a small area in the center of the retina responsible for sharp, detailed vision. This buildup of fluid causes the macula to thicken and swell, which can distort central vision and lead to vision loss if not treated promptly. Macular edema is often a complication of other eye conditions such as diabetic retinopathy, age-related macular degeneration, retinal vein occlusion, or uveitis. It's important to note that while macular edema can affect anyone, it is more common in people with certain medical conditions like diabetes.

Ophthalmology is a branch of medicine that deals with the diagnosis, treatment, and prevention of diseases and disorders of the eye and visual system. It is a surgical specialty, and ophthalmologists are medical doctors who complete additional years of training to become experts in eye care. They are qualified to perform eye exams, diagnose and treat eye diseases, prescribe glasses and contact lenses, and perform eye surgery. Some subspecialties within ophthalmology include cornea and external disease, glaucoma, neuro-ophthalmology, pediatric ophthalmology, retina and vitreous, and oculoplastics.

A Retinal Vein is a vessel that carries oxygen-depleted blood away from the retina, a light-sensitive layer at the back of the eye. The retinal veins originate from a network of smaller vessels called venules and ultimately merge to form the central retinal vein, which exits the eye through the optic nerve.

Retinal veins are crucial for maintaining the health and function of the retina, as they facilitate the removal of waste products and help regulate the ocular environment. However, they can also be susceptible to various pathological conditions such as retinal vein occlusions, which can lead to vision loss or damage to the eye.

Cytokines are a broad and diverse category of small signaling proteins that are secreted by various cells, including immune cells, in response to different stimuli. They play crucial roles in regulating the immune response, inflammation, hematopoiesis, and cellular communication.

Cytokines mediate their effects by binding to specific receptors on the surface of target cells, which triggers intracellular signaling pathways that ultimately result in changes in gene expression, cell behavior, and function. Some key functions of cytokines include:

1. Regulating the activation, differentiation, and proliferation of immune cells such as T cells, B cells, natural killer (NK) cells, and macrophages.
2. Coordinating the inflammatory response by recruiting immune cells to sites of infection or tissue damage and modulating their effector functions.
3. Regulating hematopoiesis, the process of blood cell formation in the bone marrow, by controlling the proliferation, differentiation, and survival of hematopoietic stem and progenitor cells.
4. Modulating the development and function of the nervous system, including neuroinflammation, neuroprotection, and neuroregeneration.

Cytokines can be classified into several categories based on their structure, function, or cellular origin. Some common types of cytokines include interleukins (ILs), interferons (IFNs), tumor necrosis factors (TNFs), chemokines, colony-stimulating factors (CSFs), and transforming growth factors (TGFs). Dysregulation of cytokine production and signaling has been implicated in various pathological conditions, such as autoimmune diseases, chronic inflammation, cancer, and neurodegenerative disorders.

Nogueira, C.; Meehan, T. & O'Donoghue, G. (2014). "Refsum's Disease and Cochlear Implantation". Annals of Otology, Rhinology, ... Adult Refsum disease may be divided into the adult Refsum disease 1 and adult Refsum disease 2 subtypes. The former stems from ... Refsum disease is an autosomal recessive neurological disease that results in the over-accumulation of phytanic acid in cells ... Adult Refsum disease should not be confused with infantile Refsum disease, a peroxisome biogenesis disorder resulting from ...
Wang, D; Zhou, J (2021). "The Kinocilia of Cochlear Hair Cells: Structures, Functions, and Diseases". Frontiers in Cell and ... such as polycystic kidney disease, congenital heart disease, mitral valve prolapse, and retinal degeneration, called ... Its importance to human biology has been underscored by the discovery of its role in a diverse group of diseases caused by the ... In addition, a defect of the primary cilium in the renal tubule cells can lead to polycystic kidney disease (PKD). In another ...
Autoimmune disease is recognized as a cause of cochlear damage. Although rare, autoimmune processes can target the cochlea ... People with HIV/AIDS may develop hearing problems due to the disease itself, medications they take for the disease, or an ... Ménière's disease (endolymphatic hydrops) occurs when there is elevated pressure in the endolymph in the cochlea. Its symptoms ... Charcot-Marie-Tooth disease variant 1E (CMT1E) is noted for demyelinating in addition to deafness. ...
Its areas of expertise include cancer treatment, kidney disease and cochlear implants. It has an affiliated research centre, ...
"Cochlear implantation is safe and effective in patients with MYH9-related disease". Orphanet Journal of Rare Diseases. 9: 100. ... MYH9-related disease. Mutations in MYH9 cause a Mendelian autosomal-dominant disorder known as MYH9-related disease (MYH9-RD). ... February 2014). "MYH9-related disease: a novel prognostic model to predict the clinical evolution of the disease based on ... The disease is transmitted as an autosomal-dominant trait, however, about 35% of index cases are sporadic. Sporadic forms ...
... "cochlear Meniere's disease frequently develops into Meniere's disease." Conversely, A 2006 study from doctors at the House Ear ... Cochlear hydrops (or cochlear Meniere's or cochlear endolymphatic hydrops) is a condition of the inner ear involving a ... Treatment for cochlear hydrops is the same as for Meniere's disease. Currently, no cure exists for either. If a patient has ... It is a form of endolymphatic hydrops and related to Ménière's disease. Cochlear hydrops refers to a case of inner-ear hydrops ...
Occasionally, the very young, the very old, or patients with a significant number of medical diseases at once may remain for ... Media related to Cochlear implants at Wikimedia Commons Cochlear Implants at Curlie Cochlear Implants information from the ... In the past, cochlear implants were only approved for people who were deaf in both ears; as of 2014[update] a cochlear implant ... Critics of cochlear implants from Deaf cultures also assert that the cochlear implant and the subsequent therapy often become ...
"Can we prevent cochlear implant recipients from developing pneumococcal meningitis?". Clinical Infectious Diseases. 46 (1): e1- ... 2010 update by the infectious diseases society of america". Clinical Infectious Diseases. 50 (3): 291-322. doi:10.1086/649858. ... Meningococcal disease occurs in epidemics in areas where many people live together for the first time, such as army barracks ... Other clues on the cause of meningitis may be the skin signs of hand, foot and mouth disease and genital herpes, both of which ...
... patchy localized cochlear disease (with or without fenestral involvement) to either the basal cochlear turn (grade 2A), or the ... Hence, the progression of disease is considerably slowed down and active disease process is arrested. This treatment cannot ... While the disease is considered to be hereditary, its penetrance and the degree of expression is so highly variable that it may ... The cochlear promontory may have a faint pink tinge reflecting the vascularity of the lesion, referred to as the Schwartz sign ...
... used as a measure of disease frequency in epidemiology Cochlear implant Chemical injury syndrome, an increased sensitivity to ...
... cochlear diseases MeSH C09.218.568.217 - endolymphatic hydrops MeSH C09.218.568.217.500 - Ménière's disease MeSH C09.218. ... auditory diseases, central MeSH C09.218.807.186.094 - auditory perceptual disorders MeSH C09.218.807.186.432 - hearing loss, ... 568.315 - labyrinthitis MeSH C09.218.568.900 - vestibular diseases MeSH C09.218.568.900.883 - vertigo MeSH C09.218.705.496 - ... central MeSH C09.218.807.800 - vestibulocochlear nerve diseases MeSH C09.218.807.800.675 - neuroma, acoustic MeSH C09.218. ...
... surgery of the endolymphatic sac for Ménière's disease and cochlear implant surgery. It is more and more common in the United ... Conditions treated by neurotologists include: Vestibular (balance) diseases, such as Ménière's disease and vestibular ... and who treat diseases of the ear with medicine or surgery. In some instances, otology and neurotology are considered together- ... with diseases that affect the ears, balance system, temporal bone, skull base, and related structures of the head and neck. ( ...
Deep brain stimulation (DBS) has been effective at treating movement disorders such as Parkinson's disease, and cochlear ... Immunohistochemical markers showed a surprising presence of hyperphosphorylated tau, an indicator of Alzheimer's disease, near ...
... present in Ménière's disease Cochlear hydrops, a variant of Meniere's disease/Endolymphatic Hydrops without vertigo. Hydrops ...
This includes late deafened adults, cochlear implant users, and people who experience tinnitus, Meniere's disease, hyperacusis ...
Occasionally, if the disease has damaged blood vessels in the ear, cochlear implantation may be used to restore some sense of ... The classic form of the disease was first described by D. G. Cogan in 1945. Cogan syndrome is a rare, rheumatic disease ... Eye diseases, Deafness, Syndromes affecting the cornea, Syndromes affecting hearing, Rare syndromes, Autoimmune diseases). ... For more severe disease, oral corticosteroids may be necessary to reduce the inflammatory response. When large amounts of ...
There is no active congenital venereal disease. Here are the requirements for the Height and Weight standards to qualify for ... No hearing impairment, deformities/disabilities in-ears vestibule-cochlear system. ...
For more significantly impaired hearing, cochlear implants may also be considered. 30-50% of individuals with Norrie disease ... Peripheral vascular disease (PVD) has also been associated with Norrie disease. In a study of 56 patients with Norrie disease, ... Norrie disease is a rare disease and genetic disorder that primarily affects the eyes and almost always leads to blindness. It ... Norrie disease is caused by a mutation in the Norrin cystine knot growth factor gene, also known as the Norrie disease ( ...
Cochlear implant, Celiac or Coeliac disease, Congenital Adrenal Hyperplasia, Congenital heart defect, Cortical blindness, ... medical disciplines and genetic diseases programs. The organization's purpose is to help children with pediatric diseases to " ... Some bears are not for specific diseases but support for children and doctors. These include a bear for bullying and bears for ... Each bear has a specific name, disease, and shirt. Some bears are specialized with crutches, masks, hearing aids, and other ...
... hyperacusis and cochlear hydrops (a rare form of Ménière's disease). Silberman was unsure he could continue singing, and ...
... and Heart diseases. More Cochlear implant surgeries were performed during the period. More Organ implantation surgeries were ... Express News Service (4 October 2012). "43 cochlear implant surgeries performed". New Indian Express. Webdesk (4 April 2021 ...
It separates the cochlear duct from the vestibular duct. It helps to transmit vibrations from fluid in the vestibular duct to ... It may be damaged in Ménière's disease. It is named after the German anatomist Ernst Reissner. The vestibular membrane ... The vestibular membrane may be ruptured by an increase in the pressure of endolymph in the cochlear duct. This may occur in ... This alternative name is named after German anatomist Ernst Reissner (1824-1878). Floor of cochlear duct. Spiral limbus and ...
Generating inner ear organoids containing putative cochlear hair cells from human pluripotent stem cells. Cell Death & Disease ... Li-dong Z, Jun L, Yin-yan H, Jian-he S, Shi-ming Y. Supporting Cells-a New Area in Cochlear Physiology Study. J Otol. 2008 Jun ... Cochlear implants are a more invasive treatment that bypass the hair cells completely by sending electrical signals from the ... The cochlear implant involves a surgically implanted electrode array and an external device that processes sound. All studied ...
... and the microstimulation used in the treatments of Parkinson's disease (Deep Brain Stimulation) and deafness (Cochlear implants ...
... sensory or cognitive modality that might have been damaged as a result of an injury or a disease. Cochlear implants provide an ... Cochlear implants have been very successful among these three categories. Today the Advanced Bionics Corporation, the Cochlear ... Cochlear and brainstern auditory prostheses "neural interface for hearing restoration: Cochlear and brain stem implants". ... Proceedings of the IEEE 96:1076-84 J. K. Niparko and B. W. Wilson, "History of cochlear implants," in Cochlear Implants: ...
Feldman, Gerald L; Weaver, D. D; Lovrien, E. W (1977). "The Fetal Trimethadione Syndrome". American Journal of Diseases of ... "Timed conditional null of connexin26 in mice reveals temporary requirements of connexin26 in key cochlear developmental events ... Onkal, R; Djamgoz, M. B (2009). "Molecular pharmacology of voltage-gated sodium channel expression in metastatic disease: ... Disease. 4 (6): e652. doi:10.1038/cddis.2013.174. PMC 3698542. PMID 23744352. Pei, L; Wiser, O; Slavin, A; Mu, D; Powers, S; ...
... and kidney and heart diseases. Forty-three Cochlear implant surgeries were performed under a Cochlear implant scheme for ... Express News Service (4 October 2012). "43 cochlear implant surgeries performed". New Indian Express. Webdesk (4 April 2021 ...
The corresponding subtypes of MD are called vestibular MD, showing symptoms of vertigo, and cochlear MD, showing symptoms of ... Ménière's disease (MD) is a disease of the inner ear that is characterized by potentially severe and incapacitating episodes of ... Finally in 1995, the list was again altered to allow for degrees of the disease: Certain - Definite disease with ... Ménière's disease usually starts confined to one ear; it extends to both ears in about 30% of cases. People may start out with ...
This cochlear synaptopathy has been seen after prolonged noise exposure in both primate and non-primate models. Two possible ... Some diseases of unknown etiology have been proposed to be synaptopathies. Examples include autism spectrum disorder and ... Age-related cochlear synaptic and neural degeneration has also been demonstrated in mice. Molecules such as FMRP1 act as ... A synaptopathy is a disease of the brain, spinal cord or peripheral nervous system relating to the dysfunction of synapses. ...
"Free cochlear implants at Govt ENT Hospital soon". Times of India. 10 April 2015. Retrieved 24 July 2019. "treatment". ... Government ENT Hospital, which serves ear, nose and throat Diseases across Coastal Andhra, is located in Pedda Waltair, ... The hospital started a cochlear implant surgery programme in 2015. The hospital serves not only in Andhra Pradesh state it also ...
Group B Streptococcus Meningitis in a Child with Cochlear Implant. Emerging Infectious Diseases. 2009;15(10):1695-1696. doi: ... Risk of bacterial meningitis in children with cochlear implants. N Engl J Med. 2003;349:435-45. DOIPubMedGoogle Scholar ... Invasive group B streptococcal disease in children beyond early infancy. Pediatr Infect Dis J. 1995;14:278-81. DOIPubMedGoogle ... A population-based assessment of invasive disease due to group B Streptococcus in nonpregnant adults. N Engl J Med. 1993;328: ...
Nogueira, C.; Meehan, T. & ODonoghue, G. (2014). "Refsums Disease and Cochlear Implantation". Annals of Otology, Rhinology, ... Adult Refsum disease may be divided into the adult Refsum disease 1 and adult Refsum disease 2 subtypes. The former stems from ... Refsum disease is an autosomal recessive neurological disease that results in the over-accumulation of phytanic acid in cells ... Adult Refsum disease should not be confused with infantile Refsum disease, a peroxisome biogenesis disorder resulting from ...
A cochlear implant does not restore normal hearing. ... A cochlear implant can help individuals who are severely hard ... Use of Vaccines to Prevent Meningitis in Persons with Cochlear Implants (Centers for Disease Control and Prevention) ... Cochlear Implants (Food and Drug Administration) * Cochlear Implants (National Institute on Deafness and Other Communication ... A cochlear implant is a small, complex electronic device that can help to provide a sense of sound. People who are profoundly ...
Signal Intensity Ratio of Cochlear Basal Turn Increased in Affected Ear in Meniere Disease News 02/01/24 By Elana Gotkine ... SIGNAL INTENSITY RATIO OF COCHLEAR BASAL TURN INCREASED IN AFFECTED EAR IN MENIERE DISEASE / ... The SIR was higher in the unaffected ear in Meniere disease than that of both ears in healthy controls. There was a positive ... was examined between the SIR of the affected ear and the grades of cochlear and vestibular hydrops in Meniere disease. ...
Tau phosphorylation and cochlear apoptosis cause hearing loss in 3×Tg-AD Mouse Model of Alzheimers Disease. / Wang, Sheue Er; ... Tau phosphorylation and cochlear apoptosis cause hearing loss in 3×Tg-AD Mouse Model of Alzheimers Disease. Chinese Journal of ... Tau phosphorylation and cochlear apoptosis cause hearing loss in 3×Tg-AD Mouse Model of Alzheimers Disease. In: Chinese ... Tau phosphorylation and cochlear apoptosis cause hearing loss in 3×Tg-AD Mouse Model of Alzheimers Disease. ...
A series of 9 patients with bilateral Ménière disease who underwent cochlear implant surgery showed overall excellent ... Patients with cochlear malformations are still candidates for cochlear implantation, but they may require a different type of ... Ménière disease. Ménière disease is characterized by room-spinning vertigo, fluctuating hearing, tinnitus, or aural fullness. ... encoded search term (Indications for Cochlear Implants) and Indications for Cochlear Implants What to Read Next on Medscape ...
Susac syndrome (SS) is a rare retinal-cochlear-cerebral disease with an unclear etiology. A 35-year-old man presented with ... The review in nutshell would provide the basic awareness of the disease that will have an impact in disease management and ... Certain components of the disease (such as obesity, diabetes, and renal problems) when noticed earlier offer a disease ... The disease mapped to at least twenty different genes (BBS1-BBS20), follow oligogenic inheritance pattern. BBS proteins ...
Congenital and pre-lingual hearing loss, cochlear implantation, chronic ear disease, pediatric airway management, congenital ... Reliability of Measuring Insertion Depth in Cochlear Implanted Infants and Children Using Cochlear View Radiography.. 32450736 ... Migration of a cochlear implant ground electrode through the calvarium of a pediatric patient.. 25547958 International journal ... Migration of a cochlear implant ground electrode through the calvarium of a pediatric patient.. 25547958 International journal ...
They are currently used to treat brain tremors and Parkinsons disease as movement simulators and cochlear implants to covey ... It studies the biological aspects of human organs such as heart disease, asthma, diabetes, and cancer. These diseases are ... BANs are specially used for patients with chronic diseases or older people. It is also used to track the performance of ... 110] designed a neural network-based mobile app that has pretrained disease predictions for users. Chiu et al. [96] proposed an ...
Patients with Refsum disease are unable to degrade phytanic acid because of a deficient activity of phytanoyl-CoA hydroxylase ( ... Refsum disease (RD) is a neurocutaneous syndrome that is characterized biochemically by the accumulation of phytanic acid in ... Cochlear implantation in Refsums disease. Cochlear Implants Int. 2008 Jun. 9(2):97-102. [QxMD MEDLINE Link]. ... Diseases & Conditions Refsum Disease * 2003/viewarticle/do-statins-have-effect-severe-disease-people-noncirrhotic- ...
Balance disorders Ménières disease Hearing problems Grommets Implantable hearing aids Cochlear implants Sees... ... Balance disorders Ménières disease Hearing problems Grommets Implantable hearing aids Cochlear implants Sees... ... General paediatric and adult otolaryngology Sinus surgery Diseases of the ear Cochlear and other hearing implants Sees... ... General paediatric and adult otolaryngology Sinus surgery Diseases of the ear Cochlear and other hearing implants Sees... ...
Pediatric hearing loss, chronic ear disease, and cochlear implantation. pediatric congenital and acquired head and neck masses ... Acoustic neuromas, glomus tumors, and other skull base diseases, cochlear implants and hearing loss disorders, otosclerosis, ... pediatric sinus disease. advanced surgery for obstructive sleep apnea. facial nerve disorders ... Neurotology, hearing loss, balance disorders, facial nerve disorders, skull base tumors, ear infections, cochlear implants ...
... changes in the organ of Corti and lateral cochlear wall in experimental endolymphatic hydrops and human Menières disease ... Correlation between Vestibular Evoked Myogenic Potentials and Disease Progression in Ménières Disease Subject Area: Audiology ... Correlation between Vestibular Evoked Myogenic Potentials and Disease Progression in Ménières Disease. ORL 12 September 2019; ... Cervical vestibular evoked myogenic potentials, Ocular vestibular evoked myogenic potentials, Ménières disease ...
... like a cochlear implant, chronic heart disease, or chronic lung disease. ... Note: An outbreak is when a disease happens in greater numbers than expected in a particular area. If you have questions about ... This vaccine will protect the newborn from severe RSV disease. ...
This website is provided by the Agency for Toxic Substances and Disease Registry (ATSDR) ONLY as an historical reference for ... Tsubaki and Irukayama (1977) have indicated that cochlear lesions may be responsible for some of the hearing loss in Minamata ... Agency for Toxic Substances and Disease Registry, 4770 Buford Hwy NE, Atlanta, GA 30341. Contact CDC: 800-232-4636 / TTY: 888- ... Agency for Toxic Substances and Disease Registry. 4770 Buford Hwy NE. Atlanta, GA 30341-3717 USA ...
Cochlear Implants Cochlear implants can help many kids with severe hearing loss. Find out how they work and who can get them. ... Panners Disease Panners disease is a painful bone condition linked to overuse of the elbow. Kids with Panners disease need ... Lyme Disease Lyme disease can affect the skin, joints, nervous system, and other organ systems. If Lyme disease is diagnosed ... Inflammatory Bowel Disease (IBD) Inflammatory bowel disease (IBD) refers to two chronic diseases that cause intestinal ...
... in improving cochlear flow and symptoms... for patients with Menieres disease (MD), tinnitus, and cochlear hypoperfusion.... ... It is not intended to diagnose, treat, cure, mitigate, or prevent any diseases, illnesses, or imbalances and should not be used ... Associated topics: ears - "[We] investigate[d] antimicrobial treatment of an infected [Staphylococcus aureus] cochlear implant ... Treatment of infected cochlear implants with novel agents such as tea tree oil could significantly improve salvage outcome.". ...
... in improving cochlear flow and symptoms... for patients with Menieres disease (MD), tinnitus, and cochlear hypoperfusion.... ... It is not intended to diagnose, treat, cure, mitigate, or prevent any diseases, illnesses, or imbalances and should not be used ... Associated topics: ears - "[We] investigate[d] antimicrobial treatment of an infected [Staphylococcus aureus] cochlear implant ... Treatment of infected cochlear implants with novel agents such as tea tree oil could significantly improve salvage outcome.". ...
Certain medical conditions (eg, chronic disorders, immunocompromising conditions, cerebrospinal fluid leaks, cochlear implants ... European Centre for Disease Prevention and Control (ECDC): Pneumococcal Disease: Recommended vaccinations 2023 ... Pneumococcal disease Pneumococcal Infections Streptococcus pneumoniae (pneumococci) are gram-positive, alpha-hemolytic, aerobic ... Adults aged 19 to 64 years at highest risk of pneumococcal disease (eg, with functional or anatomic asplenia, chronic kidney ...
Adult & paediatric ear disease, paediatric otolaryngology, cochlear implantation, acoustic tumour surgery, skull base surgery, ... Adult & paediatric ear disease, paediatric otolaryngology, cochlear implantation, acoustic tumour surgery, skull base surgery, ...
Disease-Specific Instruments in Children. Six studies reported on disease-specific QoL metrics, which include youth QoL deaf ... Disease-Specific Instruments in Adults. Nine studies reported on disease-specific QoL instruments in adults, most specific to ... Disease-Specific Instruments in Older Adults. Two studies reported on disease-specific QoL instruments in adults, including the ... UK Cochlear Implant Study Group: Criteria of candidacy for unilateral cochlear implantation in postlingually deafened adults II ...
Pneumococcal disease is a serious infection caused by the bacterium Streptococcus pneumoniae, also known as pneumococcus. This ... Individuals with specific medical conditions, such as chronic kidney disease, asplenia, or cochlear implants, are at an ... Conditions such as chronic lung diseases (e.g., chronic obstructive pulmonary disease), heart diseases, liver diseases, ... These conditions include immunocompromising conditions, chronic lung diseases, and heart or liver diseases. ...
Neuroimaging is not typically used to locate the offending cochlear lesion in Menieres disease, and associated high-frequency ... Restricting fluid intake is not a recommended prevention or prophylaxis method for Menieres disease. Menieres disease is ... Menieres disease is largely a diagnosis of exclusion, meaning that other possible causes of the symptoms must be ruled out ... As the disease progresses, the cupping becomes more pronounced, indicating worsening damage to the optic nerve. Arteriovenous ...
Diseases and illnesses like Ménières disease, autoimmune inner ear disease, cochlear otosclerosis, chronic ear infections, and ... Understanding Menieres Disease: Causes, Symptoms, and Treatment Options * What Are Otoacoustic Emissions and How Are They Used ... MS is considered an immune-mediated disease.. This simply means the bodys immune system attacks the wrong target, in this case ... Through inflammation, this disease attacks healthy sheathing that insulates the nerves around the brain and spinal cord. ...
Discover the impact of age on cochlear implant outcomes in adults with severe hearing loss. Explore a retrospective study ... and 7 had Menieres disease. Of the older patients, 66 lost their hearing because of idiopathic hearing loss; 28 had familial ... UK Cochlear Implant Study Group (2004) Criteria of Candidacy for Unilateral Cochlear Implantation in Postlingually deafened ... The Impact of Age on Cochlear Implant Performance () Brian Schwab, Michele Gandolfi, Erica Lai, Erin Reilly, Lorie Singer, Ana ...
... which several researchers think was caused by Pagets disease, cochlear otosclerosis, or an autoimmune disorder such as ...
Cochlear implants or are about to get cochlear implants. *Immune deficiency because of a disease or treatment, including cancer ... Pneumococcal disease is a very serious disease. It is a major cause of illness and death, particularly amongst the very young. ... What is pneumococcal disease?. Pneumococcal disease is a bacterial infection caused by streptococcus pneumoniae of which there ... Centers for Disease Control and Prevention-Epidemiology and Prevention of Vaccine Preventable Diseases "The Pink Book-12th ...
Her laboratory has developed and uses mouse models to understand how these and other mutations cause disease. Most recently, ... Seminar - Matthew Winn, AuD, PhD - Topic: Listening Effort in Cochlear Implant Users. September 29 @ 12:00 pm - 1:00 pm ... Dolan Lecture - Laura Ranum, PhD - "RAN Translation in Neurologic Disease". April 12, 2019 @ 12:00 pm - 1:00 pm. ... Her laboratory has developed and uses mouse models to understand how these and other mutations cause disease. Most recently, ...
One of the heart conditions that young people are susceptible to is Rheumatic Heart Disease /Vascular Heart Disease. ... ENT & Cochlear Implant. We provide the complete diagnostic and treatment of disease and conditions associated with the ear, ... Diseases Treated by Homoeopathy are Infectious Diseases, Viral Diseases, Diseases of Infancy and Childhood & Allergic Disorder. ... Liver diseases, Renal diseases, Diet related to pregnancy and lactation, Cardiac diseases, Weight management and many more. ...
  • Cochlear implantation is the standard treatment for children and adults affected by severe and severe-to-profound sensorineural hearing loss. (
  • Although individual responses to cochlear implants are highly variable and depend on a number of physical and psychosocial factors, the trend toward improved performance with increasingly sophisticated electrodes and programming strategies has dramatically expanded indications for cochlear implantation. (
  • Because preoperative expectations affect the patient's postoperative satisfaction and use of the implant, all patients and families require attention and counseling from an implant team before they embark on the life-changing journey of cochlear implantation. (
  • The HINT measures word-recognition abilities to evaluate the patient's candidacy for cochlear implantation, in conjunction with conventional pure-tone and speech audiometry. (
  • Visual-motor integration skills of prelingually deaf children: implications for pediatric cochlear implantation. (
  • To review evidence regarding the health-related quality of life (HRQoL) and cost-effectiveness of unilateral and bilateral cochlear implantation (CI) among children and adults with severe-to-profound hearing loss. (
  • Since its introduction into clinical practice, hearing care clinicians have increasingly utilized cochlear implantation (CI) to restore auditory stimulation in selected patients with advanced sensorineural hearing loss. (
  • Objective: Cochlear implantation is the emerging treatment of choice for severe and profound sensorineural hearing loss, yet there are conflicting data on outcomes in adults. (
  • Complications were retrospectively collected after each cochlear implantation. (
  • The aim of this study was to evaluate the hearing outcome of cochlear implantation in. (
  • The results clearly demonstrate significant benefit of cochlear implantation in prelinguistically deafened children for speech perception ability when using either the SPEAK or ACE speech coding strategies. (
  • Surgical Labyrinthectomy and Cochlear Implantation in Menière's Disease. (
  • OBJECTIVE: The aim of this study was to analyze the results of labyrinthectomy and cochlear implantation (CI) on hearing, vertigo, and tinnitus and evaluate the adequacy of labyrinthectomy and CI for the treatment of end stage Menière's Disease (MD). (
  • After the shock of finding out our baby was completely deaf, we were thrilled to learn that Chicago had one of the top otolaryngology surgeons in the country who specializes in cochlear implantation," Max's mom, Kristen said. (
  • Can cochlear implantation prevent cognitive decline in the long-term follow-up? (
  • This suggests that older adults benefit equally from cochlear implantation. (
  • Auditory rehabilitation by cochlear implantation has a stimulating effect on cognitive functions beyond an improvement in speech understanding and an increased well-being. (
  • [ 6 ] However, many candidates for cochlear implants do not have access to this procedure, due to failure to recognize appropriate candidates or because of inadequate healthcare resources. (
  • Cochlear implants can be fitted for those patients with permanent deafness / hearing loss. (
  • General paediatric and adult otolaryngology Sinus surgery Diseases of the ear Cochlear and other hearing implants Sees. (
  • Treatment of infected cochlear implants with novel agents such as tea tree oil could significantly improve salvage outcome. (
  • Certain medical conditions (eg, chronic disorders, immunocompromising conditions, cerebrospinal fluid leaks, cochlear implants) increase the risk of pneumococcal disease. (
  • The fellowship allows you to work with faculty who specialize in all areas of pediatric otolaryngology including large volumes of cochlear implants, chronic ear disease, and open airway surgery. (
  • Cochlear implants have been used for many years to replace lost hearing resulting from inner ear damage. (
  • The most successful neuroprosthetic devices developed to date are cochlear implants for patients with hearing impairment, and prosthetic devices for amputees. (
  • We saw Dr. Nancy Young and she explained that the sooner Max gets cochlear implants , the better his chances at developing normal speech. (
  • Cochlear implants enable children to hear even high-pitched consonants, such as "s," when traditional hearing aids cannot because of the degree of loss, said Dr. Young, who has performed more than 1,700 cochlear procedures since 1991. (
  • Many children don't receive cochlear implants until they are older, and by that time their speech is impacted," she said. (
  • In severe hearing loss cochlear implants (CI) are the option of choice ( 12 - 14 ). (
  • Preoperative high-resolution computed tomography of the temporal bones showed bilateral inner ear malformations of both the cochlear and vestibular labyrinth, conditions consistent with bilateral Mondini deformity ( 5 ). (
  • The differences of bilateral SIR were compared between Meniere disease and healthy controls, and the correlation was examined between the SIR of the affected ear and the grades of cochlear and vestibular hydrops in Meniere disease. (
  • Mild or moderate cochlear symptoms with high frequency hearing loss were related to age, and severe vestibular symptoms were related to the severity of facial paralysis after onset of herpetic symptoms. (
  • Examples included presbycusis, noise-induced hearing loss, Ménière disease, and retrocochlear lesions such as vestibular schwannoma. (
  • Clinically typical dementia Alzheimer's disease (AD) is associated with abnormal auditory processing. (
  • Homozygous SLITRK6 c.1240C>T (p.Gln414Ter) nonsense mutations are associated with high myopia, cochlear dysfunction attributed to outer hair cell disease, and progressive auditory neuropathy. (
  • Sensorineural hearing loss is secondary to cochlear abnormalities and/or an abnormality of the auditory nerve or central auditory pathways. (
  • Starting in 2022, persons with certain underlying diseases will be offered vaccination against invasive pneumococcal infections within a national vaccination programme. (
  • About 736,900 registered cochlear implant devices had, as of December 2019, been placed in patients worldwide. (
  • Meniere's disease. (
  • for patients with Meniere's disease (MD), tinnitus, and cochlear hypoperfusion. (
  • Sensorineural hearing loss in the inner ear or hearing nerve may be due to the effects of ageing, exposure to loud noise, Meniere's disease or some medications and infections. (
  • Meniere's disease is an abnormality of the inner ear causing a host of symptoms, including vertigo or severe dizziness, tinnitus or a roaring sound in the ears, fluctuating hearing loss, and the sensation of pressure or pain in the affected ear. (
  • A team of scientists from the University of Granada (UGR) and GENYO (Pfizer-University of Granada-Andalusian Government Centre for Genomics and Oncological Research-led by Pablo Roman-Naranjo and Jose Antonio López-Escámez, researcher in charge of the Biohealth Research Institute in Granada (ibs.GRANADA)-has identified new genes associated with familial Meniere's disease. (
  • Sound Pharmaceuticals is pleased to announce that it began enrolling a clinical trial to test SPI-1005 in the treatment of Meniere's Disease (MD). MD or idiopathic endolymphatic hydrops is an inner ear disease that involves episodic vertigo, sensorineural hearing loss, and tinnitus. (
  • Otonomy, Inc., a clinical stage biopharmaceutical company developing innovative therapeutics for diseases and disorders of the inner and middle ear, today announced enrollment of the first patient in its pivotal Phase 2b study of OTO-104 for the reduction of vertigo in patients with unilateral Meniere's disease. (
  • Researchers at University of Colorado School of Medicine may have figured out what causes Meniere's disease and how to attack it. (
  • According to Carol Foster, MD, from the department of otolaryngology and Robert Breeze, MD, a neurosurgeon, there is a strong association between Meniere's disease and conditions involving temporary low blood flow in the brain such as migraine headaches. (
  • Meniere's disease is a disorder of the inner ear that affects balance and hearing. (
  • In the early stages, Meniere's disease is usually unilateral (occurring on one side). (
  • Meniere's disease is also called idiopathic endolymphatic hydrops . (
  • The cause of Meniere's disease is unknown. (
  • Genetic predisposition - Approximately 5%-20% of individuals diagnosed with Meniere's disease report that a family member has or had Meniere's disease or similar symptoms. (
  • In addition, chromosomal studies appear to be making progress in identifying certain genetic markers in individuals diagnosed with Meniere's disease. (
  • Allergies - Individuals with Meniere's disease report higher rates of allergies than people not affected with Meniere's, and some studies have shown higher rates of serum immune markers in individuals with Meniere's disease than those without. (
  • In addition, studies have shown that individuals with allergies and Meniere's disease report an improvement in the severity and duration of their Meniere's attacks when treated with immunotherapy and/or dietary adjustments. (
  • Migraine headaches - There appears to be an association between Meniere's disease and migraine headaches. (
  • and that 45% of individuals with Meniere's disease always experienced at least one symptom of migraine headaches (e.g., aura, or an aversion to light) during Meniere's attacks. (
  • Otosclerosis - Some individuals with otosclerosis (a rare condition of formation of spongy bone around the stapes) have symptoms of Meniere's disease. (
  • It is also not clear whether endolymphatic hydrops is the cause or the result of Meniere's disease, since there are known cases of individuals with endolymphatic hydrops who otherwise have no symptoms of Meniere's disease. (
  • While Meniere's disease is the second most common cause of vertigo in the U.S., it is listed in the National Organization of Rare Diseases (NORD) database as a rare disease. (
  • Information regarding the precise incidence and prevalence of Meniere's disease is scarce, but some estimates range from 15 to 150 cases per 100,000 people. (
  • Meniere's disease most often affects adults between the ages of 40 and 60. (
  • Approximately 40,000 new cases of Meniere's disease are diagnosed annually in the U.S. (
  • Approximately 3% of patients diagnosed with Meniere's disease are children. (
  • Although most cases of Meniere's disease are usually unilateral (occurring on one side only), up to 10% of individuals have bilateral Meniere's disease affecting both ears at the time of diagnosis. (
  • There is no consistent pattern for the progression of Meniere's disease. (
  • The diagnosis of Meniere's disease can be challenging because there are many other conditions that can present with similar clinical symptoms. (
  • Pediatric cochlear implant recipients were found to be at higher risk for developing bacterial meningitis than children in the general US population ( 3 ). (
  • Dr. Horn is the medical Co-Director of the Pediatric Cochlear Implant program at Seattle Childrens Hospital and sees patients with hearing loss, ear disorders, balance issues, as well as other general pediatric otolaryngological problems. (
  • Dr. Young is the founder of the Lurie Children's Cochlear Implant Program , one of the largest pediatric implant programs in the world. (
  • The significant disease burden from congenital CMV infection (cCMV) led the US National Institute of Medicine to rank CMV vaccine development as the highest priority. (
  • Centers for Disease Control and Prevention. (
  • [ 1 ] According to the US Centers for Disease Control and Prevention (CDC), of babies screened in the United States in 2019, 1.7 per 1000 had hearing impairment. (
  • For more information, see Pneumococcal Advisory Committee on Immunization Practices Vaccine Recommendations and Centers for Disease Control and Prevention (CDC): Pneumococcal Vaccination . (
  • The Centers for Disease Control and Prevention (CDC) provides recommendations regarding pneumococcal vaccination for different age groups and high-risk individuals. (
  • ACIP is chartered as a federal advisory committee to provide expert external advice and guidance to the Director of the Centers for Disease Control and Prevention (CDC) on use of vaccines and related agents for the control of vaccine-preventable diseases in the civilian population of the United States. (
  • The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (
  • Administration (FDA) approved an expanded usage for PCV15 aged 6-18 years with an immunocompromising condition,¶ to include persons aged 6 weeks-17 years, based on studies that cerebrospinal fluid leak, or cochlear implant (a subset of risk compared antibody responses to PCV15 with those to PCV13 conditions). (
  • A minimum interval of 8 weeks between PCV15 and PPSV23 can be considered for adults with an immunocompromising condition, cochlear implant, or cerebrospinal fluid (CSF) leak. (
  • Adults with an immunocompromising condition, cochlear implant, or cerebrospinal fluid leak who have received both PCV13 and PPSV23 with incomplete vaccination status are recommended to complete their pneumococcal vaccine series by receiving either a dose of PCV20 at least 5 years after the last pneumococcal vaccine dose or PPSV23 as previously recommended. (
  • The sound is then transmitted to the fluid and delicate hair cells of the inner ear (cochlear). (
  • For the purposes of this workshop, immune mediated ear disease was defined to include both primary autoimmune sensorineural hearing loss (ASNHL) originating in the inner ear and secondary immune mediated ear disease/hearing loss (IMED) from systemic immune/autoimmune disease originating outside the inner ear. (
  • During cochlear implant surgery, electrodes are threaded into the inner ear while the body of the device is secured beneath the scalp behind the ear. (
  • In 80% of patients diagnosed with Refsum disease, sensorineural hearing loss has been reported. (
  • Weidong Zhang, M.D., from the Zhengzhou University People's Hospital and Henan Provincial People's Hospital in China, and colleagues enrolled 30 patients with unilateral definite Meniere disease and 24 healthy controls to compare the SIR of the cochlear basal turn. (
  • As increased permeability of the blood-labyrinth barrier precedes the formation of endolymphatic hydrops, it is suggested that disruption of the blood-labyrinth barrier may contribute to the development of Meniere disease in patients," the authors write. (
  • For patients with hearing loss that is not mitigated by hearing aids, a cochlear implant may provide an opportunity for hearing. (
  • Certain components of the disease (such as obesity, diabetes, and renal problems) when noticed earlier offer a disease management benefit to the patients. (
  • However, the awareness of the disease is comparatively low and most often noticed only after severe vision loss in patients, which is usually in the first decade of the patient's age. (
  • The review in nutshell would provide the basic awareness of the disease that will have an impact in disease management and counseling benefits to the patients and their families. (
  • But, as estimated in [ 4 ], it is getting challenging for the traditional healthcare system to monitor a huge number of patients with chronic diseases. (
  • Therefore, healthcare systems have to monitor patients to handle a huge number of patients with chronic diseases and make the treatment affordable and easily accessible to them. (
  • Therefore, polymyalgia rheumatica is a concomitant disease frequently seen in patients with giant cell arteritis. (
  • MS patients will experience the condition in one of four disease courses (types of MS): Primary progressive MS, secondary progressive MS, relapsing-remitting MS, or clinically isolated syndrome. (
  • Audio logical assessment in patients with herpes zoster oticus were performed to determine the biologic features of the varicella zoster virus (VZV) and the pathogenesis of vestibule cochlear nerve disease in herpes zoster oticus. (
  • A retrospective study review of 60 patients with herpes zoster oticus was designed in order to determine the classic characteristics of vestibule cochlear nerve disease associated with the syndrome. (
  • Among 60 patients, 30 had a complaint of cochlear symptoms, were undergone for audio logical assessment. (
  • Speech Recognition During Follow-Up of Patients with Ménière's Disease: What Are We Missing? (
  • Distortion product otoacoustic emissions (DPOAEs) were absent in all ears tested and the cochlear microphonic (CM) was increased in amplitude and duration in young patients and absent in the two oldest subjects. (
  • These preliminary findings clearly delineate the importance of further research aimed at investigating hearing impairment in AD, to a) allow early detection of people with predisposition to AD, b) improve the quality of life in AD patients with hearing loss and c) possibly prevent the progression of the disease treating the hearing impairment. (
  • Global Kinetics' Personal KinetiGraph (PKG), a wearable device for Parkinson's disease patients, provided more information about symptoms than a routine clinic visit, a recent study found. (
  • Medtronic (NYSE:MDT) said today that it won expanded approval for its deep-brain stimulation therapy for patients with Parkinson's disease, which 1st won approval from the safety watchdog in 2002. (
  • Patients with Refsum disease are unable to degrade phytanic acid because of a deficient activity of phytanoyl-CoA hydroxylase (PhyH), a peroxisomal enzyme catalyzing the first step of phytanic acid alpha-oxidation. (
  • Blood levels of phytanic acid are increased in patients with Refsum disease. (
  • Cochlear implanted children with prelinguistic sensorineural bilateral deafness of profound degree, using either the ACE or SPEAK coding strategy, were evaluated and compared. (
  • In a large prospective longitudinal monocentric study, 50 adults (aged ≥ 50 years) with severe postlingual bilateral hearing loss received a cochlear implant (CI). (
  • The presence of hearing loss in the elderly is described by the term "presbycusis" it typically presents as sensorineural hearing loss characterized by loss in the high frequencies[ 10 ] ( Figure 1 ) and sometimes may be associated to the presence of cochlear dead regions[ 11 ]. (
  • Sensorineural hearing loss (SNHL) from cochlear implant surgery and samples (2 mL) were obtained on the is a type of hearing loss in which the serology findings. (
  • Most meningitis cases were associated with an implant with a positioner, a silastic wedge inserted next to the implanted electrode in the cochlea to position the electrode closer to the cochlear nerve endings and thus facilitate electrical signal transmission. (
  • Navneet G, Reeta G, Abhaya L, Kalu R, Aquib M D. The Pathogenesis of Vestibule Cochlear Nerve Disease in Herpes Zoster Oticus. (
  • He explained these eighth nerve features by the close proximity of the geniculate ganglion to the vestibule cochlear nerve within the bony facial canal [ 2 ]. (
  • Hemorrhage of the cochlear nerve and destruction of the apex of the organ of Corti have been reported. (
  • The findings were compared with the clinical severity of facial paralysis and patient age to clarify the pathogenesis of vestibule cochlear nerve disease in herpes zoster oticus. (
  • Unilateral CI across all age groups leads to reported sustained benefits in the recipients' overall and disease-specific QoL. (
  • Individuals at higher risk of developing pneumococcal bacteremia include those with underlying health conditions, such as diabetes or chronic liver disease. (
  • However, the fact is that the number of heart disease cases among the population below 30 years of age are increasing dramatically worldwide, majorly due to lifestyle choices which include but not limited to alcohol abuse, excessive smoking, obesity, diabetes, and others. (
  • The cochlear implant is a surgically placed device that converts sound to an electrical signal. (
  • A cochlear implant is an electronic device that is surgically implanted. (
  • When he was just over six months old, Max's ears were both surgically implanted with a cochlear implant, an electronic device that allowed him to hear, learn to understand speech and speak clearly. (
  • What are the symptoms of pneumococcal disease? (
  • Chest pain -Discomfort or severe pain in the chest or heaviness radiating to your left arm and back are the symptoms of the heart disease. (
  • The incidence of cochlear symptoms in herpes zoster oticus was not related to the severity of facial paralysis. (
  • Myth 4: Alzheimer's disease symptoms are normal as we get older. (
  • Several medications are now available to treat symptoms and slow the disease in some people. (
  • Reuters) - The FDA last week said it approved a brain implant from St. Jude Medical (NYSE:STJ) that helps reduce symptoms of Parkinson's disease and essential tremor, a neurological disorder that causes rhythmic shaking. (
  • Community-acquired pneumonia (CAP) is one of the most common infectious diseases and an important cause of mortality and morbidity worldwide. (
  • Hearing loss may result from genetic causes, complications at birth, certain infectious diseases, chronic ear infections, the use of particular drugs, exposure to excessive noise, and ageing. (
  • Wang, SE & Wu, CH 2021, ' Tau phosphorylation and cochlear apoptosis cause hearing loss in 3×Tg-AD Mouse Model of Alzheimer's Disease ', Chinese Journal of Physiology , vol. 64, no. 2, pp. 61-71. (
  • When hearing loss is more serious or when hearing is entirely impaired, a hearing or cochlear implant is a more effective option. (
  • It is never "too late" to get a cochlear implant, nor is age-related hearing loss just something to put up with, said Dr Heywood. (
  • On July 22-23, 2008, the National Institute on Deafness and Other Communication Disorders (NIDCD) convened a workshop at the Hyatt Regency Bethesda in Bethesda, MD, titled Immune Mediated Ear Disease/Hearing Loss . (
  • Investigations of hearing loss associated with the presence of systemic autoimmune disease, e.g. (
  • Hearing loss is usually mild to moderate, and the audio logical data suggest cochlear and/or retro cochlear involvement [ 3 ]. (
  • Many studies have focused on the relationship between hearing loss and Alzheimer's Disease (AD). (
  • MTRH on Wednesday, June 21 announced the inaugural surgery (cochlear) that helps a patient with severe hearing loss or profoundly deaf to get some sense of sound. (
  • Idiopathic (unexplained) hearing loss 119 SNHL children having cochlear Student t-test was used to determine may be the result of an infectious disease implant surgery, ranging in age from 3 significant differences in means and or an injury [1]. (
  • The Clinical Practice Guideline: Ménière's Disease in Otolaryngology-Head and Neck Surgery has been published today. (
  • Conclusion: This is one of the largest series to date on hearing outcomes in adults who receive a cochlear implant. (
  • Before 2021, ACIP recommended 23-valent pneumococcal polysaccharide vaccine (PPSV23) alone (up to 2 doses), or both a single dose of 13-valent pneumococcal conjugate vaccine (PCV13) in combination with 1-3 doses of PPSV23 in series (PCV13 followed by PPSV23), for use in U.S. adults depending on age and underlying risk for pneumococcal disease. (
  • In adults, pneumococcal pneumonia is the most common type of pneumococcal disease, and pneumococcus is the most common bacterial cause of pneumonia that results in hospitalization ( 3 ). (
  • cochlear hemoglobinopathies. (
  • Pneumococcal disease is a serious infection caused by the bacterium Streptococcus pneumoniae, also known as pneumococcus. (
  • Pneumococcal disease is a bacterial infection caused by streptococcus pneumoniae of which there are more than 90 serotypes. (
  • The vaccinations that are offered to all children protect against eleven diseases: rotavirus infection, diphtheria, tetanus, whooping cough, polio, infections caused by Haemophilus influenzae type b, measles, mumps, rubella, serious diseases caused by pneumococcus and human papillomavirus (HPV). (
  • The true global burden of cCMV disease is likely underestimated because most infected infants (85-90 %) have asymptomatic infection and are not identified. (
  • Vaccines are directed against many of the serotypes that cause disease. (
  • CDC's National Center for Immunization and Respiratory Diseases (NCIRD) maintains the most current immunization schedules on the Vaccines and Immunizations pages of CDC's website ( ), including the schedules published in this supplement. (
  • Most vaccines that are part of the Swedish child vaccination programme are given as combination vaccines, i.e. vaccines against several diseases are given in the same shot in order to minimize the number of injections. (
  • Our histochemical staining evidence showed the cochlear spiral ganglion neurons (SGN), but not the cochlear hair cells, were lost significantly in the cochlea of 3×Tg-AD mice from 9 months of age and thereafter. (
  • This electrical signal is transmitted via electrodes to the spiral ganglion cells in the cochlear modiolus. (
  • Andrews' Diseases of the Skin: Clinical Dermatology (10th ed. (
  • Adult Refsum disease may be divided into the adult Refsum disease 1 and adult Refsum disease 2 subtypes. (
  • Adult Refsum disease should not be confused with infantile Refsum disease, a peroxisome biogenesis disorder resulting from deficiencies in the catabolism of very long chain fatty acids and branched chain fatty acids (such as phytanic acid) and plasmalogen biosynthesis. (
  • Based on the above, it was proposed that adult Refsum disease could be divided into types 1 and 2, depending on which gene is defective. (
  • : (accessed 11 April 2016). (
  • Refsum disease is an autosomal recessive neurological disease that results in the over-accumulation of phytanic acid in cells and tissues. (
  • Refsum disease typically is adolescent onset and is diagnosed by above average levels of phytanic acid. (
  • Individuals with Refsum disease present with neurologic damage, cerebellar degeneration, and peripheral neuropathy. (
  • citation needed] Refsum disease is a peroxisomal disorder caused by the impaired alpha-oxidation of branched chain fatty acids resulting in buildup of phytanic acid and its derivatives in the plasma and tissues. (
  • In general, Refsum disease is caused by PHYH mutations. (
  • Refsum disease is inherited in an autosomal recessive pattern, meaning that it requires both copies of the mutation to inherit the disease. (
  • Refsum disease 2 stems from mutations in the peroxin 7 (PEX7) gene. (
  • Since phytanic acid is not endogenously produced in the human body, individuals with Refsum disease are commonly placed on a phytanic acid-restricted diet and avoid the consumption of fats from ruminant animals and certain fish, such as tuna, cod, and haddock. (
  • Refsum disease (RD) is a neurocutaneous syndrome that is characterized biochemically by the accumulation of phytanic acid in plasma and tissues. (
  • In Refsum disease (RD), the phytanic acid level in the blood is increased. (
  • Refsum disease can be classified as a peroxisome biogenesis disorder. (
  • [ 1 ] Infantile Refsum disease is a peroxisome biogenesis disorder. (
  • Refsum disease is a recessive disorder characterized by defective peroxisomal alpha-oxidation of phytanic acid. (
  • [ 7 ] A Refsum disease gene, phytanoyl-CoA hydroxylase ( PHYH ), has been localized to band 10p13 between the markers D10S226 and D10S223. (
  • [ 8 ] Refsum disease is genetically heterogeneous, with up to 55% of cases not being linked to the PAHX gene locus at D10S547 to D10S223. (
  • Recently, a mouse model for Refsum disease ( Phyh knockout mouse by targeted disruption of the PHYH gene). (
  • An infantile form of Refsum disease also exists and is an autosomal recessive disorder of peroxisomal biogenesis, leading to many biochemical abnormalities, including elevated plasma concentration of phytanic acid, pristanic acid, very long chain fatty acids, and C27 bile acids. (
  • Refsum disease is rare, with just 60 cases published worldwide. (
  • Infantile Refsum disease makes its appearance in early infancy. (
  • Alzheimer's disease affects millions of Americans and is a leading cause of death in the United States. (
  • Myth 1: Alzheimer's disease and dementia are the same thing. (
  • Myth 2: I will develop Alzheimer's disease if my parent has it. (
  • Myth 3: Only people in their 70s and older develop Alzheimer's disease. (
  • Myth 5: There are no treatments available for people with Alzheimer's disease. (
  • Alzheimer's Disease (AD) is an acquired condition characterized by progressive cognitive and behavioural decline and is the second most common form of dementia in the general population after mild cognitive impairment[ 1 ]. (
  • Cochlear implant recipients have been documented as having a higher rate of postimplantation bacterial meningitis than a cohort of the same age in the general US population ( 3 ). (
  • The pneumococcal vaccine plays a critical role in protecting individuals, particularly those who are more susceptible to pneumococcal diseases. (
  • Background: Chronic conditions increase the risk of invasive pneumococcal diseases (IPD). (
  • and children aged 24-71 months with certain underlying medical conditions at increased risk for pneumococcal disease* who have not received age-appropriate doses. (
  • If the rheumatic heart disease is diagnosed in the early stages with minimum damage to the heart valve, Antibiotics are used to treat strep infections and prevent rheumatic fever thereof. (
  • We report a case of GBS meningitis in a 6-year-old boy with a cochlear implant. (
  • This association is believed to be due to the autoimmune nature of both diseases, where the immune system mistakenly attacks healthy tissues. (
  • Chronic diseases microbial-non-susceptibility of pneumococcus. (
  • The SIR was higher in the unaffected ear in Meniere disease than that of both ears in healthy controls. (
  • Rheumatic Heart Disease can lead to various other complications such as a ruptured heart valve, which would require required immediate surgery or replacement of a heart valve. (
  • Cochlear implant surgery is very safe and takes about two hours, Dr Heywood says. (
  • The Moi Teaching and Referral Hospital in Eldoret has successfully performed the first cochlear implant surgery on a patient. (
  • There is significant variability in the literature concerning the exact effect of age on cochlear implant outcomes. (
  • We sought to evaluate the outcomes of cochlear implant performance stratified by age. (
  • PCV13 is effective against acute otitis media, pneumonia, and vaccine (PPSV23 [Merck Sharp & Dohme LLC]) have been invasive pneumococcal disease (IPD) in children ( 5 - 7 ). (
  • The decrease in this age group can largely be attributed to a 98% decline in Invasive pneumococcal disease (IPD) due to serotypes covered by PCV7 between 2008 and 2016. (
  • Certain persons with pneumococcal colonization might develop invasive pneumococcal disease (IPD) ( 2 ). (
  • One of the heart conditions that young people are susceptible to is Rheumatic Heart Disease /Vascular Heart Disease. (
  • Both kits were used and the conditions that can result in acquired out in the cochlear implant centre of results were calculated qualitatively. (
  • Pneumococcal disease can lead to significant morbidity and mortality, particularly amongst the very young, the very old, those with impaired immunity and those with anatomic or functional asplenia. (