Agents useful in the treatment or prevention of COCCIDIOSIS in man or animals.
Drugs used by veterinarians in the treatment of animal diseases. The veterinarian's pharmacological armamentarium is the counterpart of drugs treating human diseases, with dosage and administration adjusted to the size, weight, disease, and idiosyncrasies of the species. In the United States most drugs are subject to federal regulations with special reference to the safety of drugs and residues in edible animal products.
Drugs and their metabolites which are found in the edible tissues and milk of animals after their medication with specific drugs. This term can also apply to drugs found in adipose tissue of humans after drug treatment.
Protozoan infection found in animals and man. It is caused by several different genera of COCCIDIA.
Domesticated birds raised for food. It typically includes CHICKENS; TURKEYS, DUCKS; GEESE; and others.
A genus of protozoan parasites of the subclass COCCIDIA. Various species are parasitic in the epithelial cells of the liver and intestines of man and other animals.
Diseases of birds which are raised as a source of meat or eggs for human consumption and are usually found in barnyards, hatcheries, etc. The concept is differentiated from BIRD DISEASES which is for diseases of birds not considered poultry and usually found in zoos, parks, and the wild.
The collective designation of three organizations with common membership: the European Economic Community (Common Market), the European Coal and Steel Community, and the European Atomic Energy Community (Euratom). It was known as the European Community until 1994. It is primarily an economic union with the principal objectives of free movement of goods, capital, and labor. Professional services, social, medical and paramedical, are subsumed under labor. The constituent countries are Austria, Belgium, Denmark, Finland, France, Germany, Greece, Ireland, Italy, Luxembourg, Netherlands, Portugal, Spain, Sweden, and the United Kingdom. (The World Almanac and Book of Facts 1997, p842)
Activities involved in ensuring the safety of FOOD including avoidance of bacterial and other contamination.
A publication issued at stated, more or less regular, intervals.
A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
Foodstuff used especially for domestic and laboratory animals, or livestock.
The composition of a committee; the state or status of being a member of a committee.
A group of SESQUITERPENES and their analogs that contain a peroxide group (PEROXIDES) within an oxepin ring (OXEPINS).
Agents used in the treatment of malaria. They are usually classified on the basis of their action against plasmodia at different stages in their life cycle in the human. (From AMA, Drug Evaluations Annual, 1992, p1585)
A family of diphenylenemethane derivatives.
A republic in central Africa lying east of CHAD and the CENTRAL AFRICAN REPUBLIC and west of NIGERIA. The capital is Yaounde.
Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations.
Single preparations containing two or more active agents, for the purpose of their concurrent administration as a fixed dose mixture.
A 4-aminoquinoline compound with anti-inflammatory properties.
Detailed account or statement or formal record of data resulting from empirical inquiry.
Databases containing information about PROTEINS such as AMINO ACID SEQUENCE; PROTEIN CONFORMATION; and other properties.
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
The portion of an interactive computer program that issues messages to and receives commands from a user.
Sequential operating programs and data which instruct the functioning of a digital computer.
Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.
An NADPH-dependent enzyme that catalyzes the conversion of L-ARGININE and OXYGEN to produce CITRULLINE and NITRIC OXIDE.
A class of enzymes that catalyze oxidation-reduction reactions of amino acids.
A CALCIUM-dependent, constitutively-expressed form of nitric oxide synthase found primarily in ENDOTHELIAL CELLS.
Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
Compounds that inhibit HMG-CoA reductases. They have been shown to directly lower cholesterol synthesis.
A CALCIUM-independent subtype of nitric oxide synthase that may play a role in immune function. It is an inducible enzyme whose expression is transcriptionally regulated by a variety of CYTOKINES.
Disorders affecting the motor function of the UPPER ESOPHAGEAL SPHINCTER; LOWER ESOPHAGEAL SPHINCTER; the ESOPHAGUS body, or a combination of these parts. The failure of the sphincters to maintain a tonic pressure may result in gastric reflux of food and acid into the esophagus (GASTROESOPHAGEAL REFLUX). Other disorders include hypermotility (spastic disorders) and markedly increased amplitude in contraction (nutcracker esophagus).
An application that must be submitted to a regulatory agency (the FDA in the United States) before a drug can be studied in humans. This application includes results of previous experiments; how, where, and by whom the new studies will be conducted; the chemical structure of the compound; how it is thought to work in the body; any toxic effects found in animal studies; and how the compound is manufactured. (From the "New Medicines in Development" Series produced by the Pharmaceutical Manufacturers Association and published irregularly.)
Substances made up of an aggregation of small particles, as that obtained by grinding or trituration of a solid drug. In pharmacy it is a form in which substances are administered. (From Dorland, 28th ed)
The medical science concerned with the prevention, diagnosis, and treatment of diseases in animals.
An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.
A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precursors of certain vitamins, bile acids, alcohols (STEROLS), and certain natural drugs and poisons. Steroids have a common nucleus, a fused, reduced 17-carbon atom ring system, cyclopentanoperhydrophenanthrene. Most steroids also have two methyl groups and an aliphatic side-chain attached to the nucleus. (From Hawley's Condensed Chemical Dictionary, 11th ed)
A device that delivers medication to the lungs in the form of a dry powder.
Food products manufactured from poultry.
Individuals enrolled in a school of pharmacy or a formal educational program leading to a degree in pharmacy.
Formal instruction, learning, or training in the preparation, dispensing, and proper utilization of drugs in the field of medicine.
A milky, product excreted from the latex canals of a variety of plant species that contain cauotchouc. Latex is composed of 25-35% caoutchouc, 60-75% water, 2% protein, 2% resin, 1.5% sugar & 1% ash. RUBBER is made by the removal of water from latex.(From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed). Hevein proteins are responsible for LATEX HYPERSENSITIVITY. Latexes are used as inert vehicles to carry antibodies or antigens in LATEX FIXATION TESTS.
A plant genus of the family EUPHORBIACEAE, order Euphorbiales, subclass Rosidae. Commercial natural RUBBER is mainly obtained from Hevea brasiliensis but also from some other plants.
A high-molecular-weight polymeric elastomer derived from the milk juice (LATEX) of HEVEA brasiliensis and other trees and plants. It is a substance that can be stretched at room temperature to at least twice its original length and after releasing the stress, retract rapidly, and recover its original dimensions fully.
Passive agglutination tests in which antigen is adsorbed onto latex particles which then clump in the presence of antibody specific for the adsorbed antigen. (From Stedman, 26th ed)
MAMMARY GLANDS in the non-human MAMMALS.
INFLAMMATION of the BREAST, or MAMMARY GLAND.
Infections with bacteria of the family PASTEURELLACEAE.

Salinomycin-induced polyneuropathy in cats: morphologic and epidemiologic data. (1/100)

In April 1996, an outbreak of toxic polyneuropathy in cats occurred in the Netherlands. All cats had been fed one of two brands of dry cat food from one manufacturer. Chemical analyses of these foods, stomach contents, and liver and kidney of affected cats revealed contamination with the ionophor salinomycin. Epidemiologic and clinical data were collected from 823 cats, or about 1% of the cats at risk. In 21 affected cats, postmortem examination was performed. The affected cats had acute onset of lameness and paralysis of the hindlimbs followed by the forelimbs. Clinical and pathologic examination indicated a distal polyneuropathy involving both the sensory and motor nerves.  (+info)

In-vitro activity of polycationic peptides against Cryptosporidium parvum, Pneumocystis carinii and yeast clinical isolates. (2/100)

The in-vitro activity of magainin II, indolicidin and ranalexin against 14 clinical isolates of eukaryotic microorganisms was evaluated. Antifungal susceptibility testing was performed by broth microdilution, and activity against Pneumocystis carinii and Cryptosporidium parvum was determined by inoculation on to cell monolayers. For yeasts, peptide MICs and MFCs ranged from 6.25 to > 50 mg/L. Ranalexin showed the highest activity against Candida spp., while magainin II demonstrated greatest anticryptococcal activity. The peptides suppressed the growth of P. carinii by > or = 50% and > or = 90% at 5 and 50 microM, respectively, with the exception of indolicidin. Ranalexin, the most effective compound against C. parvum, suppressed its growth by > or = 40% at 50 microM.  (+info)

Anticryptosporidial activity of ranalexin, lasalocid and azithromycin alone and in combination in cell lines. (3/100)

The in vitro anticryptosporidial activities of ranalexin, lasalocid and azithromycin alone and in combination were investigated against four clinical isolates of Cryptosporidium parvum. Susceptibility was tested by inoculating the isolates on to cell monolayers and determining the parasite count after 48 h incubation at 37 degrees C. The culture medium was supplemented with Dulbecco's modified Eagle's medium containing serial dilutions of the above-mentioned compounds. Ranalexin showed moderate anticryptosporidial activity: at a concentration of 64 mg/L it reduced parasite counts by 33.8%. Azithromycin at a concentration of 8 mg/L gave inhibition comparable to that observed with the highest concentration of ranalexin. Lasalocid showed the highest activity, with a 70.3% reduction in parasite counts at 2 mg/L. The combination of ranalexin 64 mg/L and lasalocid 2 mg/L completely suppressed parasite growth without harming the monolayer.  (+info)

Anti-toxoplasma activities of antiretroviral drugs and interactions with pyrimethamine and sulfadiazine in vitro. (4/100)

The anti-Toxoplasma activities of nine antiretroviral drugs were examined in vitro. Nucleoside analogs had no effect on parasite growth, whereas ritonavir and nelfinavir were inhibitory for Toxoplasma, with 50% inhibitory concentrations of 5.4 and 4.0 microg/ml, respectively. None of the antiviral drugs affected the anti-Toxoplasma activity of pyrimethamine or sulfadiazine.  (+info)

Recent advances in biology and immunobiology of Eimeria species and in diagnosis and control of infection with these coccidian parasites of poultry. (5/100)

Avian coccidiosis, an intestinal disease caused by protozoan parasites of the genus Eimeria, occurs worldwide. It is considered to be one of the most economically important diseases of domestic poultry. For many years, prophylactic use of anticoccidial feed additives has been the primary means of controlling coccidiosis in the broiler industry and has played a major role in the growth of this industry, which now can produce about 7.6 billion chickens annually. However, development of anticoccidial resistance has threatened the economic stability of the broiler industry. Although there has been little effort by the pharmaceutical industry to develop new anticoccidials, the mounting problem of drug resistance of Eimeria species has prompted major research efforts to seek alternative means of control through increased knowledge of parasite biology, host response, and nutritional modulation. As a consequence, important advancements have been made, particularly in defining parasite antigens that have potential use in vaccines, defining the Eimeria genome, understanding the immunology of coccidial infections, and the practical applications of live vaccines. This review describes the progress in these areas, most of which has occurred within the past 10 to 15 years.  (+info)

Disruption of microtubules uncouples budding and nuclear division in Toxoplasma gondii. (6/100)

The tachyzoite stage of the protozoan parasite Toxoplasma gondii has two populations of microtubules: spindle microtubules and subpellicular microtubules. To determine how these two microtubule populations are regulated, we investigated microtubule behavior during the cell cycle following treatment with microtubule-disrupting drugs. Previous work had established that the microtubule populations are individually nucleated by two distinct microtubule-organizing centers (MTOCs): the apical polar ring for the subpellicular microtubules and spindle pole plaques/centrioles for the spindle microtubules. When replicating tachyzoites were treated with 0.5 microM oryzalin or 1.0 mM colchicine they retained the capacity to form a spindle and undergo nuclear division. Although these parasites could complete budding, they lost the bulk of their subpellicular microtubules and the ability to reinvade host cells. Both nascent spindle and subpellicular microtubules were disrupted in 2.5 microM oryzalin or 5.0 mM colchicine. Under these conditions, parasites grew in size and replicated their genome but were incapable of nuclear division. After removal from 0.5 microM oryzalin, Toxoplasma tachyzoites were able to restore normal subpellicular microtubules and a fully invasive phenotype. When oryzalin was removed from Toxoplasma tachyzoites treated with 2.5 microM drug, the parasites attempted to bud as crescent-shaped tachyzoites. Because the polyploid nuclear mass could not be correctly segregated, many daughter parasites lacked nuclei altogether although budding and scission from the maternal mass was able to be completed. Multiple MTOCs permit Toxoplasma tachyzoites to control nuclear division independently from cell polarity and cytokinesis. This unusual situation grants greater cell cycle flexibility to these parasites but abolishes the checks for coregulation of nuclear division and cytokinesis found in other eukaryotes.  (+info)

Effect of wean-to-finish management on pig performance. (7/100)

In each of three trials, 240 crossbred barrows weaned at 17 d of age (5.1 kg BW) were assigned to one of three experimental treatments based on light and heavy weight outcome groups. Experimental treatments were 1) wean-to-finish at 0.69 m2/pig and 15 pigs/pen; 2) wean-to-finish double-stocked at 0.35 m2/pig, 30 pigs per pen for 8 wk and then randomly split into two pens (either stayed in same pen or moved to new pen) for growth to slaughter at 0.69 m2/pig; and 3) nursery facility for 8 wk at 0.35 m2/pig and 15 pigs/pen followed by move to the same grow-finish facility housing wean-to-finish and double-stocked pigs and maintaining pen integrity. Beginning at 38 kg BW, diets were supplemented with either bacitracin methylenedisalicylate at 33 mg/kg to slaughter or tylosin at 44 mg/kg to 59 kg BW and 22 mg/kg thereafter. There were no trial x treatment interactions, even though there was considerable variation in health status among trials. At the end of the 56-d nursery period, wean-to-finish pigs weighed more than nursery (28.7 vs 27.7 kg; P = 0.071) and double-stocked pigs (28.7 vs 26.9 kg; P = 0.002), due to greater ADG (wean-to-finish vs nursery; P = 0.062; wean-to-finish vs double-stocked; P = 0.002) and greater ADFI (wean-to-finish vs nursery; P = 0.024; wean-to-finish vs double-stocked, P = 0.002). There was no effect of treatments (P > 0.1) on ADG, feed conversion, carcass lean percentage, or lean gain during the growing-finishing period. There was also no effect of treatment (P > 0.1) on ADG or ADFI from weaning to slaughter. There was no difference (P > 0.1) between bacitracin methylenedisalicylate and tylosin for ADG, feed conversion, carcass lean percentage, or daily lean gain. These data suggest that housing 5-kg weaned pigs in fully slatted growing-finishing facilities from weaning to slaughter was not detrimental to overall performance. In this experiment, dietary additions of bacitracin methylenedisalicylate or tylosin from 38 kg BW to slaughter weight resulted in similar growth performance.  (+info)

Efficacy of common laboratory disinfectants on the infectivity of Cryptosporidium parvum oocysts in cell culture. (8/100)

Nine liquid disinfectants were tested for their ability to reduce infectivity of Cryptosporidium parvum oocysts in cell culture. A 4-min exposure to 6% hydrogen peroxide and a 13-min exposure to ammonium hydroxide-amended windshield washer fluid reduced infectivity 1,000-fold. Other disinfectants tested (70% ethanol, 37% methanol, 6% sodium hypochlorite, 70% isopropanol, and three commercial disinfectants) did not reduce the infectivity after a 33-min exposure. The results indicate that hydrogen peroxide and windshield washer fluid or ammonium hydroxide disinfectant may be suitable laboratory disinfectants against C. parvum oocysts.  (+info)

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[65 Pages Report] Check for Discount on [1,3-Bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene]bis(2-bromopyridine)dichloro(phenylmethylene)ruthenium Global Market and Forecast Research report by ChemReport. DescriptionWe provide independent and unbiased information on manufacturers, prices, production...
What are the symptoms?. In cats, it causes diarrhea. The stool is often highly liquid in consistency. You may also see blood in the stool, as they cause damage to the intestines. The cat may get dehydrated as a result of the diarrhea.. Is it serious?. Yes - a cat will get dehydrated from the diarrhea and may lose blood. It makes the pet very ill and susceptible to other infections, and sometimes they die if they get sick from something else at the same time. You need to take the pet to the vet, because it is easily treatable, but it can take a week for them to get over it. What is the treatment? There are a couple of treatments. Antibiotics are often used, as well as coccidiostats, which are medicines designed to help the cats immune system fight back specifically against coccidia. Keeping the cat hydrated is also very important. Albon is one of the most commonly used drugs against it. Is it contagious to other pets or to people?. Both dogs and cats can get the same kind of coccidia - but ...
Commission Implementing Regulation (EU) 2015/1105 of 8 July 2015 concerning the authorisation of a preparation of Bifidobacterium animalis ssp. animalis DSM 16284, Lactobacillus salivarius ssp. salivarius DSM 16351 and Enterococcus faecium DSM 21913 as a feed additive for chickens reared for laying and minor poultry species other than laying, the authorisation of that feed additive for use in water for drinking for chickens for fattening and amending Regulation (EU) No 544/2013 as regards the maximum content of that feed additive in complete feedingstuff and its compatibility with coccidiostats (holder of the authorisation Biomin GmbH ...
Poultry feeds are available with several types of medications for preventing or treating diseases. Coccidiostats and/or antibiotics are the two most common medications added to feeds.
PROBOTIC 25G #VT00423 $20.00 PROBOTIC 90G #VT00054 $30.00. A concentrated water-soluble blend of 7 live microbes for use in drinking water or addition to food. Aids in the establishment of gastrointestinal micro flora in hand reared baby birds, day old chicks, puppies and kittens and other physiologically immature animals. Re-establishes natural gut flora after infections, diarrhoea, stress and the use of antibiotics. Recommended for: Baby birds being reared on a formula not produced by Vetafarm, birds recovering from illness or birds that have recently been treated with antibiotics. Probotic may be used during periods of extreme stress e.g.: overcrowding, diarrhoea, temperature extremes, transportation, training and medication; and following surgery.. Also suitable For: Dogs, Cats and Poultry Chicks. Can be used with: Probotic can be given in water or mixed in food. Probotic is compatible with feed ingredients including anthelmintics, coccidiostats, minerals and vitamins. Probotic® should NOT ...
गुणवत्ता दवा कच्चे माल निर्माताओं & निर्यातक - खरीदें White Diclazuril Raw Steroid Powders for Coccidiostat Animal Drug of Diclazuril CAS 101831-37-2 चीन से निर्माता.
There statistically januvia generic cost is limited evidence to support the notion that alcoholic beverages, breads and other foods made with yeast can lead to yeast infections. The strain was initially phenotypically tetracycline resistant and carried the tet(A) gene! A administração deve começar o mais cedo possível. A broad-spectrum antibiotic powder for use in ornamental birds for bacterial infections? The coccidiostat added to poultry (hen) grower pellets is not a treatment! Remember, when Tretinoin is used properly, many users see improvement by 12 weeks? It prolongs, celebrex vs tramadol and helps sustain the penile erec! In general, phenergan elixir over the counter uk wholesomely dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy! However, it should be noted that their philological analysis ...
3-Bromo-n-[2-(dimethylamino)ethyl]benzamide; CAS Number: 425618-78-6; Linear Formula: C11H15BrN2O; find Combi-Blocks, Inc.-COMH93D5B863 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich
Classical treatment for congenital toxoplasmosis is based on combination of sulfadiazine and pyrimethamine plus folinic acid. Due to teratogenic effects and bone marrow suppression caused by pyrimethamine, the establishment of new therapeutic strategies is indispensable to minimize the side effects and improve the control of infection. Previous studies demonstrated that enrofloxacin and toltrazuril reduced the incidence of Neospora caninum and Toxoplasma gondii infection. The aim of the present study was to evaluate the efficacy of enrofloxacin and toltrazuril in the control of T. gondii infection in human trophoblast cells (BeWo line) and in human villous explants from the third trimester. BeWo cells and villous were treated with several concentrations of enrofloxacin, toltrazuril, sulfadiazine, pyrimethamine, or combination of sulfadiazine+pyrimethamine, and the cellular or tissue viability was verified. Next, BeWo cells were infected by T. gondii (2F1 clone or the ME49 strain), whereas villous
At a press conference yesterday in Belgium, Maja Mariën of Alpharma Animal Health explained the new approach of fighting coccidiosis in poultry. The main message: rotate the use of different coccidiostats!
(1H-Indazol-3-yl)methanol 64132-13-4 NMR spectrum, (1H-Indazol-3-yl)methanol H-NMR spectral analysis, (1H-Indazol-3-yl)methanol C-NMR spectral analysis ect.
Toxoplasma gondii is a ubiquitous apicomplexan parasite capable of infecting humans and other animals. Current treatment options for T. gondii infection are limited and most have drawbacks, including high toxicity and low tolerability. Additionally, no FDA-approved treatments are available for pregnant women, a high-risk population due to transplacental infection. Therefore, the development of novel treatment options is needed. To aid this effort, this review highlights experimental compounds that, at a minimum, demonstrate inhibition of in vitro growth of T. gondii When available, host cell toxicity and in vivo data is also discussed. The purpose of this review is to facilitate additional development of anti-Toxoplasmacompounds, and potentially to extend our knowledge of the parasite ...
Acquiring therapy resistance is one of the major obstacles in the treatment of patients with cancer. The discovery of the cancer stem cell (CSC)-specific drug salinomycin raised hope for improved treatment options by targeting therapy-refractory CSCs and mesenchymal cancer cells. However, the occurrence of an acquired salinomycin resistance in tumor cells remains elusive. To study the formation of salinomycin resistance, mesenchymal breast cancer cells were sequentially treated with salinomycin in an in vitro cell culture assay, and the resulting differences in gene expression and salinomycin susceptibility were analyzed. We demonstrated that long-term salinomycin treatment of mesenchymal cancer cells resulted in salinomycin-resistant cells with elevated levels of epithelial markers, such as E-cadherin and miR-200c, a decreased migratory capability, and a higher susceptibility to the classic chemotherapeutic drug doxorubicin. The formation of salinomycin resistance through the acquisition of ...
4-fluoro-1H-indazol-3-amine; CAS Number: 404827-78-7; Linear Formula: C7H6FN3; find Key Organics / BIONET-KEY158583413 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich
Collectively our data demonstrate that the lethality of low nanomolar concentrations of salinomycin are enhanced by HDAC inhibitors in GBM cells and that increased death receptor signaling together with reduced mitochondrial function are causal in the combinatorial drug necro-apoptotic killing effect.. Salinomycin induces cell death with autophagy through activation of endoplasmic reticulum stress in human cancer cells. In conclusion, these findings provide evidence that combination treatment with salinomycin and pharmacological autophagy inhibitors will be an effective therapeutic strategy for eliminating cancer cells as well as cancer stem cells.. Salinomycin enhances doxorubicin-induced cytotoxicity in multidrug resistant MCF-7/MDR human breast cancer cells via decreased efflux of doxorubicin.. Salinomycin decreases doxorubicin resistance in hepatocellular carcinoma cells by inhibiting the β-catenin/TCF complex association via FOXO3a activation.. Salinomycin inhibits growth of pancreatic ...
Special note about Community Feature Content. Any content and/or opinions uploaded, expressed or submitted through any Community Feature or any other publicly available section of the Web Site (including password-protected areas), and all articles and responses to questions, other than the content explicitly authorized by the Company, are solely the opinions and responsibility of the person or entity submitting them and do not necessarily reflect the opinions of the Company. By way of example, any recommended or suggested use of products or services available from the Company that is posted through a Community Feature is not a sign of approval or recommendation by the Company. If you choose to follow any such recommendation you do so at your own risk.. Links to Third Party Sites. The Web Site may contain links to other websites on the internet. The Company is not responsible for the content, products, services or practices of any third party websites, including without limitation sites linked to ...
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Coccidiosis is caused in chickens by the genus Eimeria spp, and is considered as one of the dominant poultry diseases worldwide. For decades, anticoccidial products have been used for the successful control of this disease. However, long term use of these products has led to the development of resistance. The current study therefore sought to investigate the anticoccidial activity of the methanol leaf extract of Lannea schimperi on experimentally induced Eimeria tenella (E. tenella) infection in broiler chickens in an attempt to provide good alternative therapy due to increasing resistance to the conventional anticoccidial agents. Seven groups (A-G) of 4 birds were used for the experiment and five groups (A-E) were orally inoculated with 1.0 x 103 sporulated oocysts of E. tenella. Groups A, B and C were treated with 25, 50 and 100 mg/kg body weight of L. schimperi methanolic leaf extract respectively and Group D was treated with1.5 mg/ml of amprolium, group E served as negative control. Groups F and G
Background: Antimicrobial resistance and antimicrobial stewardship are of ever-increasing importance in veterinary medicine. Re-purposing of old drugs that are not used in human medicine is one approach that addresses the emergence of multidrug resistance in canine skin and ear infections, and can reduce the use of critically important human antibiotic classes. Hypothesis/Objectives: To determine the antimicrobial activity of narasin, a polyether ionophore conventionally used as a rumen modifier and anticoccidial agent in production animals, against common clinical isolates of canine otitis externa (OE). Animals/Isolates: Clinical isolates (n = 110) from canine OE were tested, including 17 meticillin-susceptible Staphylococcus pseudintermedius (MSSP), 13 multidrug-resistant Staphylococcus pseudintermedius (MDRSP), and 20 each of β-haemolytic Streptococcus spp., Pseudomonas aeruginosa, Proteus mirabilis and Malassezia pachydermatis. Methods: Bacterial and yeast isolates were subcultured, ...
GLOBAL - The poultry industry has highlighted coccidiosis as one of the most prevalent factors adversely affecting producers and processors globally.
Background: Tumor spreading is the major threat for cancer patients. The recently published anti-cancer drug salinomycin raised hope for an improved treatment by targeting therapy-refractory cancer stem cells. However, an unambiguous role of salinomycin against cancer cell migration and metastasis formation remains elusive. Findings: We report that salinomycin effectively inhibits cancer cell migration in a variety of cancer types as determined by Boyden chamber assays. Additionally, cells were treated with doxorubicin at a concentration causing a comparable low cytotoxicity, emphasizing the anti-migratory potential of salinomycin. Moreover, single-cell tracking by time-lapse microscopy demonstrated a remarkable effect of salinomycin on breast cancer cell motility. Ultimately, salinomycin treatment significantly reduced the metastatic tumor burden in a syngenic mouse tumor model. Conclusions: Our findings clearly show that salinomycin can strongly inhibit cancer cell migration independent of the ...
A 10-aa-long sequence in SLP-76 upstream of the Gads binding site is essential for T cell development and function. Prior to sampling, special considerations need to be addressed cialis side effects dangers related to various factors including current medications, health status, and hygiene practices. Coherent spike activity occurs between widely separated retinal cialis price ganglion cells (RGCs) in response to a large, contiguous object, but not to disjointed objects. 3D-CRT is an effective method in the treatment of patients with small primary hepatocellular carcinoma. Candida tropicalis was the only ascomycetous species isolated from all four sites.. We report 4 patients with retinal hemorrhages that developed during hospitalization for dengue fever. from common mynah (Acridotheres tristis) and preliminary survey of two anticoccidial drugs in natural cialis samples request infection. Experimental results on two benchmark datasets show the effectiveness of the proposed method and its ...
Structure, properties, spectra, suppliers and links for: 4-[(4-Acetyl-1-piperazinyl)carbonyl]-1-(4-fluoro-2H-indazol-3-yl)-2-pyrrolidinone.
At day 14, average feed conversion and live weights were similar in the vaccine and salinomycin groups, Mathis reports. By day 21, the vaccinated group trailed behind the nonvaccinated group. However, after 21 days, the vaccinated birds recovered and began to gain. About day 28, performance declined in birds receiving the anticoccidial due to the presence of subclinical coccidiosis. Under normal management conditions, this is a typical occurrence when this ionophore is used, Mathis notes ...
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5-Bromo-N-(3-iodophenyl)-1,3-benzothiazol-2-amine | C13H8BrIN2S | CID 43304997 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
Benzamide, 4-bromo-N-(1H-indol-3-ylphenylmethyl)-N-phenyl- | C28H21BrN2O | CID 71399214 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
You are viewing an interactive 3D depiction of the molecule 2-bromo-n-{(1e,4e)-3-methyl-4-[(phenylsulfonyl)imino]-2,5-cyclohexadien-1-ylidene}acetamide (C15H13BrN2O3S) from the PQR.
With the successful sales of its feed additives sourced from Biomin, Zintec Feed Supplements has decided to set up a stand alone division: Zintec Feed Solutions. This new division will be responsible for the distribution of feed additives to the feed industry.
Global animal feed additive market stood at $14 billion in 2012 and is expected to grow at a CAGR of 4% to $19 billion by 2020. Learn more about research focus area and patents fillings activity of animal feed additive market.
Feed additive are the functional ingredients added to the feed to aid healthy growth of animals. There are various types of feed additives catering to a...
1140 agribusiness professionals from across the globe provided their views on the use of phytogenic feed additives (PFAs, or botanicals) as part of the 2017 BIOMIN Phytogenic Feed Additives Survey.
1140 agribusiness professionals from across the globe provided their views on the use of phytogenic feed additives (PFAs, or botanicals) as part of the 2017 BIOMIN Phytogenic Feed Additives Survey.
NOR/310R0885.ohfo OJ L 265/10, p. 5-8 COMMISSION REGULATION (EU) No 885/2010 of 7 October 2010 concerning the authorisation of the preparation of narasin and nicarbazin as a feed additive for chickens
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Avian coccidiosis is an intracellular intestinal parasitic disease, caused by intracellular intestinal parasites from the genus Eimeria, among which Eimeria tenella is one of the most pathogenic species and causes great economic losses. Frequent applications of anticoccidial drugs have resulted in the development of drug-resistance in E. tenella. In the present study, we sought to determine the genetic diversity of E. tenella isolates prevalent in chicken farms in Hubei Province of China and examine their sensitivity to three anticoccidial drugs. The results provide useful information for the prevention and control of coccidiosis in this region. Eimeria tenella oocysts were isolated from faecal samples collected from different commercial broiler production farms in Hubei Province, China. After oocyst sporulation and animal inoculation for expansion of the field isolates, DNA and RNA were extracted from excysted sporozoites for molecular characterization. Species
Eimeria tenella is a species of Eimeria that causes hemorrhagic cecal coccidiosis in young poultry. It is found worldwide. This species has a monoxeous life cycle with the definitive (only) host as chickens; it is extremely host-specific. Acquired via fecal contamination of food and water (oral-fecal route), it undergoes endogenous merogony in the crypts of Lieberkuhn (intestinal ceca of chicken) and gametogony in epithelial cells of the small intestines. Fusion of microgamete and macrogamete forms results in unsporulated zygotes, which are released with feces of chicken. The zygote sporulates after one to five days, and becomes infective. Diagnosis is based on finding oocysts in feces. While no effective treatment exists, the rate of infection can be reduced via prophylates, anticoccidial drugs and vaccination of baby chicks. Eimeria tenella has a monogenetic life cycle, that is, the life cycle involves a single host. Various stages of its complicated life cycle may conveniently be described ...
Eimeria tenella is the best known poultry coccidia, because of the recognizable lesions and often spectacular losses it causes in commercial broilers or layer pullets. Eimeria tenella is the only species which causes caecal coccidiosis, one of the most easily recognized form of coccidiosis. Infection can be acute and spread rapidly, resulting in mortality in a susceptible flock or coccidiosis control program failure for replacement birds. Eimeria tenella causes bloody droppings and onset of mortality in a flock.. ...
Advanced Research on Industry, Information System and Material Engineering, IISME2011: Bioinformatic Analysis and Characteristics of the Antigen SO7 of Eimeria Tenella MY Strain
by K.J. Theodore of www.shagbarkbantams.com. Amprolium shortage? Why are you worried?. Im not. Thats because I practice prevention. And if theres anything to practice prevention for, its COCCIDIOSIS. Since Coccidiosis is one of the most flock-devastating protozoan parasitic diseases, Cocci management should forever be at the forefront of any good health and nutrition program.. If youve ever survived a round of Cocci in your own flock, you know what I mean about devastating. If youre new to the Fancy with a cute little backyard flock, your days are numbered for heartbreak.. It will come from nowhere in the form of a once healthy nice little bird suddenly looking as though theyve ruffled their feathers. They may already be sulking in a corner. Then comes the bloody diarrhea or the oozing of clear fluid from the mouth when you pick them up. By this time, its too late - most of the damage is already done, and its only taken about 96 hours to get there. Cocci outbreaks are particularly ...
Recent work has highlighted and enumerated the economic annual losses due to Neospora caninum abortions worldwide, which should provide strong motivation for the control of bovine neosporosis. However, with the recent withdrawal from sale of the only commercially available vaccine, control options for N. caninum have become more restricted. While researchers continue to work on developing alternative efficacious vaccines, what are the control options presently available for the cattle industries? At the practical level, recommendations for Test-and-cull, or not breeding from seropositive dams stand diametrically opposed to alternative options put forward that suggest a primary producer is better advised to keep those cows in the herd that are already seropositive, i.e. assumed to be chronically infected, and indeed those that have already aborted once. Treatment with a coccidiostat has been recommended as the only economically viable option, yet no such treatment has gained official, ...
Extraction and isolation. The air-dried medullae of J. effuses (6 kg) were powdered and extracted with 95% ethanol (3 × 70 L) at room temperature. The extracts were combined and concentrated under vacuum to give a residue (180 g). The residue was subjected to column chromatography over a silica gel (200-300 mesh), eluted with petroleum ether-acetone (from 10:1 to 1:1) to generate fractions 1-5. Fraction 2 (2.8 g) was subjected to medium pressure silica gel column chromatography eluted with petroleum ether-ethyl ether-acetone (20:2:1) to yield three fractions 2-1 to 2-3. Fraction 2-2 (1.21 g) was subjected to medium pressure silica gel column chromatography eluted with petroleum ether-acetone (30:1) to afford six fractions 2-2-1 to 2-2-6. Fraction 2-2-2 (860 mg) was subjected to silica gel column chromatography eluted with petroleum ether-acetone (40:1) to yield five fractions 2-2-2-1 to 2-2-2-5. Fraction 2-2-2-5 (600 mg) was chromatographed on Sephadex LH-20 (petroleum ether-CHCl3 -MeOH, ...
Designed for the treatment and prevention of coccidiosis (caused by Eimeria bovis or Eimeria zuernii) in housed heifer calves (for environmental reasons, do not use in calves over 80kg) and sheep (lambs) (caused by Eimeria crandallis and Eimeria ovinoidalis ...
We have to pay special attention to clinical Eimeria species that are able to generate lesions and symptoms that will reduce the health of the birds.
Coccidiosis is the name given to a group of closely related diseases caused by a protozoan parasite called Eimeria. The Eimeria develop inside cells lining the intestine. As the parasites reproduce they cause bleeding and massive swelling of the gut. This leads to a huge loss of liquid and the bird is unable to absorb the nutrients from its food.
When using this server please cite the following paper:. Zsila F, Bikadi Z, Malik D, Hari P, Pechan I, Berces A, Hazai E.. Evaluation of drug-human serum albumin binding interactions with support vector machine aided online automated docking.. Bioinformatics. 2011 May 18. ...
Coccidiosis treatment: DNA-based methods such as PCR have overcome some limitations of conventional methods, allowing the analysis of more samples in less time.
China Amino Acid Chelate Zinc for Feed Additive, Find details about China Zinc Aminoacid Chelate, Feed Additive from Amino Acid Chelate Zinc for Feed Additive - Chengdu Chelation Biology Technology Co., Ltd.
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Studied was the effect of tiamin at the rate of 50 mg/kg mixture and white of egg in ratios of 25 and 50 per cent to the feed on the course of coccidiosis in chickens caused by Eimeria tenella. It was found that those of the birds that were offered 25 per cent white of egg and tiamin in a dose of 100 mg per kg exhibited more severe signs of coccidiosis had more pronounced morphologic changes with a higher mortality rate and the amount of the oocysts shed was higher than the same indices in birds having received the vitamin at the rate of 50 mg per kg and white of egg in a ration of 50 per cent to the feed ...
The present invention relates to a cross-linked polyether which is obtained by polymerization of at least one monomer selected from the group consisting of (a) (α-X-methyl)vinyl-EWG, (α-X-methyl)vinyl-ERG, or (α-X-methyl)vinyl-aryl, where X is oxygen, sulfur, PEG, PPG or poly(THF); (b) a monomer which is polymerizable with a PEG, PPG or poly(THF) cross-linker having at least one (α-X-methyl)vinyl-EWG, (α-X-methyl)vinyl-ERG or (α-X-methyl)vinyl-aryl, where X is oxygen, sulfur, PEG, PPG, or poly(THF); (c) a PEG, PPG, or poly(THF) cross-linker having at least an acrylamide or a methacrylamide end group; and (d) mixtures thereof. Various monomers, resins and methods for preparing such cross-linked polyethers are also disclosed.
This Phase 1/2a, first-in-human (FIH), open-label, dose-escalation study of KO-539, a menin-MLL(KMT2A) inhibitor, will determine the safety and tolerability of escalating doses using a modified toxicity probability interval (mTPI) adaptive design when administered to patients with relapsed and/or refractory AML. If an maximum tolerated dose (MTD) cannot be identified, a recommended phase 2 dose (RP2D) will be determined. A expansion phase in patients with NPM1m and KMT2A-r R/R AML patients is planned following determination of the MTD/RP2D. KO-539 will be administered as a once daily oral dose in 28 continuous day cycles ...
Fig. 1: Economic evaluation of different application strategies for a feed additive in tilapia farming. Data show change of farm revenues and return of investment, relative to the non-supplemented control group. Treatment groups differ in inclusion of the feed additive and formulation: AG3 (control feed + 3 kg/MT Aquagest OMF throughout the production cycle), AG3/1.5 (control feed + 3 kg/MT till 350g; followed by 1.5 kg/MT till harvest), LC/AG2 (low cost feed + 2 kg/MT).. The low cost feed performed significantly worse compared to the control feed in most parameters, particularly in terms of survival, feed conversion and fileting yield. The addition of 2 kg/MT of the feed additive was only capable of improving growth but the nutritional impact of reducing the protein digestibility and amino acid balance in this feed heavily affected the overall performance, particularly FCR and survival. This resulted in 10% reduced revenues compared to control and showed the importance of maintaining the ...
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Press Release issued Sep 17, 2012: According to a new market report published by Transparency Market Research Animal Feed and Feed Additives Market - Global Industry Size, Market Share, Trends, Analysis, and Forecast, 2011 - 2018, global animal feed additives market was worth USD 13.5 billion in 2011 and is expected to reach USD 17.5 billion in 2018, growing at a CAGR of 3.8% from 2011 to 2018. In the overall global market, Asia Pacific is expected to maintain its lead position in terms of revenue till 2018. Asia Pacific is expected to enjoy 32.4% of global animal feed additives market revenue share in 2018 followed by Europe.
The Global and Chinese Animal Feed Additive Industry, 2012-2022 Market Research Report is a professional and in-depth study on the current state of the global Animal Feed Additive industry with a focus on the Chinese market. The report provides key statistics on the market status of the Animal Feed Additive manufacturers and is a valuable…
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For all the challenges performed, vaccinated groups showed a reduction in lesion scores, oocyst excretion and clinical signs compared to control groups. Weight evolution post-challenge was not affected in vaccinated animals. The duration of immunity of the vaccine EVALON® for all Eimeria species included in the vaccine was confirmed to be until the end of the production cycle (60 weeks). It is hypothesized that this extended duration of immunity in conditions that do not favour reinfections is due to the coadministration of EVALON® with the adjuvanted solvent Hipramune® T.. ...
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In general, the development of immunity is a complex process. With Eimeria , the process is further complicated by the parasites multifaceted lifecycle,...
Global Market Study on Mineral Salt Ingredients: Macro Mineral Salt Ingredients Segment Expected to Exhibit the Highest Revenue Growth
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Borregaard | Animal Feed Additives: High-performance, sustainable pellet binders and die lubricants, SoftAcid acidifiers and bypass protein technology
The major driving forces behind the animal feed and feed additives market is the worldwide increase, in the consumption of meat. Other driving factors that
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... coccidiostats and histomonostats. - Article 6, The last category was banned in 2009 by the EU, and replaced with probiotic ...
... is a coccidiostat and antibacterial agent. It is a derivative of salinomycin with an additional methyl group. Narasin ... Anadón, A.; Martínez-Larrañaga, Mr (2014). "Veterinary Drugs Residues: Coccidiostats". Encyclopedia of Food Safety: 63-75. doi: ...
... is a coccidiostat. Robenidine is an antibiotic used for the control of coccidiosis, a debilitating protozoal ...
... is a coccidiostat. Clazuril Diclazuril Ponazuril Diaferia M, Veronesi F, Morganti G, Nisoli L, Fioretti DP (August ...
... is a coccidiostat used on meat chickens. It is also used as a contraceptive for population control of Canada geese ... Unlike other coccidiostats, nicarbazin rarely presents resistance phenomena towards the most common coccidioses such as those ... Factor in the evaluation of coccidiostats in poultry. Cornell Vet. 47, 400 - 412, 1957 Polin D, Ott WH, Siegmund OH "The ... The use of nicarbazin as a coccidiostat has shown, even if in a completely reversible form, an inhibiting effect on the ...
Other coccidiostats are currently being evaluated to treat EPM. Recommended measures of prevention include proper hygiene and ...
... is a coccidiostat used in poultry. Arabkhazaeli, F.; Modrisanei, M.; Nabian, S.; Mansoori, B.; Madani, A. (2013). " ...
... (trade name Vecoxan) is a coccidiostat. Clazuril Ponazuril Toltrazuril Diaferia M, Veronesi F, Morganti G, Nisoli L ...
of Pathology, Bombay Veterinary College, Parel, Mumbai, India - A herbal coccidiostat on pathology of coccidiosis in broilers ... of Pathology, Bombay Veterinary College, Parel, Mumbai, India (25 February 2009). "A herbal coccidiostat on pathology of ... Indian Journal of Experimental Biology - Evaluation of herbal Coccidiostat 'coxynil' in broiler Dept. ... "Evaluation of herbal Coccidiostat 'Coxynil' in broiler" (PDF). Indian Journal of Experimental Biology. 44 (September 2006): 740 ...
Diclazuril and toltrazuril and other coccidiostats are being evaluated to treat EPM. No vaccines are currently known. ...
... is a quinolone coccidiostat used in veterinary medicine. Page SW (2008). Antiparasitic drugs. Small Animal Clinical ...
... is used in chicken feed as a coccidiostat. A team from the University of Cambridge has cloned and sequenced the ... Salinomycin is an antibacterial and coccidiostat ionophore therapeutic drug. Salinomycin and its derivatives exhibit high ...
... is a drug used in veterinary medicine as a coccidiostat. Diclazuril Ponazuril Toltrazuril Vanparijs O, Hermans L, Van ...
Ionophores were originally developed as coccidiostats for poultry and prevent coccidiosis in cattle as well. Ionophores work by ...
... is the organic compound sold as a coccidiostat used in poultry. It has many International Nonproprietary Names. The ... commonly used in the United States in conjunction with sulfonamides prophylactically in chickens and cattle as a coccidiostat. ...
Conlogue, G; Foreyt, WJ; Wescott, RB (1984). "Bovine coccidiosis: protective effects of low-level infection and coccidiostat ...
In dogs and cats, the most commonly administered coccidiostat is sulfa-based antibiotics. Once reproduction stops, the animal ... Coccidiosis is most commonly treated through the administration of coccidiostats, a group of medications that stop coccidia ...
... antibiotics, antifungals, cytostatics, anticholesteremic, antiparasitics, coccidiostats, animal growth promoters and ...
Some drugs listed below are ionophores, which are coccidiostats and not classified as antibiotics in many countries; they have ...
... , sold under the brand name Halocur, is a coccidiostat used in veterinary medicine. It is a synthetic halogenated ...
... is a coccidiostat used in veterinary medicine. It is a synthetic halogenated derivative of febrifugine, a natural quinazolinone ...
... is an organic compound that is used as in veterinary medicine as a coccidiostat. It is prepared industrially by a ...
There are chick feed mixes that contain a coccidiostat to manage exposure levels and control disease. In an outbreak, ...
... is an antibacterial agent and a coccidiostat, which is produced by strains of Streptomyces lasaliensis. It is the ...
... antimalarial properties and the synthetic halogenated derivative halofuginone is used in veterinary medicine as a coccidiostat ...
... is a coccidiostat (or more likely a coccidiocide, i.e. a drug killing Coccidia parasites) used in veterinary ...
... coccidiostats MeSH D27.505.954.122.250.100.875 - trypanocidal agents MeSH D27.505.954.122.388 - antiviral agents MeSH D27.505. ...
... and as a coccidiostat. As of June 2011, it was approved for chicken feed in the United States, Canada, Australia, and 12 other ...
... arsenical used as a coccidiostat and for increased weight gain selamectin - antiparasitic treating fleas, roundworms, ear mites ...
A coccidiostat is an antiprotozoal agent that acts upon Coccidia parasites. Examples include: Amprolium Arprinocid Artemether ... Oryzalin Ponazuril Robenidine Roxarsone Salinomycin Spiramycin Sulfadiazine Sulfadimethoxine Toltrazuril Coccidiostats at the ...
coccidiostat synonyms, coccidiostat pronunciation, coccidiostat translation, English dictionary definition of coccidiostat. n a ... coccidiostat. Also found in: Medical, Wikipedia. coccidiostat. (kɒkˈsɪdɪəʊˌstæt) n. a drug used to treat coccidiosis ... Coccidiostat - definition of coccidiostat by The Free Dictionary https://www.thefreedictionary.com/coccidiostat ... Prod 15,000mg; coccidiostat 10,000mg; antioxidant (BHT) 500mg.. Adjusting weight growth curve of male quails Coturnix japonica ...
The Randox Food Coccidiostat Array produces a semi-quantitative result for all of the following 12 analytes: Lasalocid, ... For the detection of coccidiostat drug residues, Biochip Array Technology (BAT) has been identified as an industry leader. ...
... [2004] Pansare, P. A., Maharashtra Animal and Fishery ... Both the coccidiostats used in the study delayed the appearance of clinical symptoms as compared to infected control group (IA ... Both the coccidiostats used in the study delayed the appearance of clinical symptoms as compared to infected control group (IA ...
Home Dairy Calf Care Center Vitamins & Supportives CORID 9.6% Oral Solution Coccidiostat for Calves ...
... coccidiostats and histomonostats. - Article 6, The last category was banned in 2009 by the EU, and replaced with probiotic ...
Coccidiostats. Supporting animal health. Our industry serves a very important segment: livestock health. As Zoetis, we strive ...
The intensification of poultry has made necessary to use chemical coccidiostats, due to the great productive effort to which ... The intensification of poultry has made necessary to use chemical coccidiostats, due to the great productive effort to which ... A: coccidiostats, B: intestinal optimizers pronutrients, C: intestinal optimizers and liver conditioning pronutrients. ... The intensification of poultry has made necessary to use chemical coccidiostats, due to the great productive effort to which ...
Diclazuril Solution, Coccidiostats for Poultry. Delivery term:The date of payment from buyers deliver within days * Price: ...
Methodology Children of either gender, between 6 months (, 5kg) and 10 years of age, with acute uncomplicated P. falciparum infection, who fulfil all of the inclusion and have none of exclusion criteria will be enrolled in the study. They will be randomised to receive the three trial arms, i.e, Study Arm-A: artesunate-amodiaquine, Study Arm-B: dihydroartemisinin-piperaquine and Study Arm-C: artemether-lumefantrine at the ratio of 2:2:1 and will be hospitalised over a 3-day period to facilitate the supervised administration of the study drugs and full clinical and laboratory assessment and observation of early adverse effects. On discharge, participants will be required to report to the study clinic on days 7, 14, 21,28, 35 and 42 or at any other time when clinical sign(s)/symptom(s) of malaria is suspected. The number of participants is about 720 children. Inclusion Criteria. ...
The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
There is an urgent need for a macrofilaricidal drug, killing or sterilizing permanently O. volvulus adult worms, which could be used in individual case management and, after appropriate testing, as an alternative drug to ivermectin in MDA programs. Emodepside is a promising candidate to kill the adult and sexually mature O. volvulus. Emodepside was shown to be macrofilaricidal against a variety of filarial nematodes and is a registered drug for animal health, commercialized by Bayer AG under the name of Profender® (in combination with praziquantel) or Procox® (in combination with toltrazuril).. A first-in-human (FIH) double-blind, placebo-controlled study of single ascending doses of emodepside in healthy Caucasian men has been conducted and the preliminary results are favourable, and support continuing the Phase I development program. For this reason, new tablet formulations have been developped and the present study will evaluate bioavailability, PK safety and tolerability, and as well food ...
Russia: Poultry farmers criticise coccidiostats restrictions On 24 Sep. In Feed additives ...
Russia: Poultry farmers criticise coccidiostats restrictions On 24 Sep. In Feed additives ...
a) Zootechnical additives, coccidiostats and histomonostats:. - the expiry date of the guarantee or the storage life from the ... 1. With a view to a decision on the phasing out of the use of coccidiostats and histomonostats as feed additives by 31 December ... b) veterinary medicinal products as defined in Directive 2001/82/EC ( 12 ), with the exception of coccidiostats and ... k) coccidiostats and histomonostats means substances intended to kill or inhibit protozoa; ...
... coccidiostat; cognition adjuvant; cognition enhancer; depressant; diagnostic aid; diuretic; dopaminergic agent; ...
... coccidiostat; cognition adjuvant; cognition enhancer; depressant; diagnostic aid; diuretic; dopaminergic agent; ...
Non-ionophore coccidiostats, which do not have antibacterial effect, are not approved in Norway. If such coccidiostats were ... Resistance to coccidiostats in coccidia and bacteria: Development of resistance in coccidia to all eleven coccidiostats has ... Without proper protection, the probability of exposure to coccidiostats is also high when handling coccidiostat premixes and ... Human exposure to resistant bacteria and coccidiostats: Humans may theoretically be exposed to coccidiostat resistant bacteria ...
"गुणवत्ता दवा कच्चे माल निर्माताओं & निर्यातक - खरीदें White Diclazuril Raw Steroid Powders for Coccidiostat Animal Drug of ... White Diclazuril Raw Steroid Powders for Coccidiostat Animal Drug of Diclazuril. Product Details:. Place of Origin: CHINA. ... बड़ी छवि : White Diclazuril Raw Steroid Powders for Coccidiostat Animal Drug of Diclazuril CAS 101831-37-2 ... White Diclazuril Raw Steroid Powders for Coccidiostat Animal Drug of Diclazuril CAS 101831-37-2. ...
Article 16. Amendments to registration or approval of an establishment. Upon request, the competent authority shall amend the registration or approval of an establishment, where it has demonstrated its capacity to develop activities which are additional to those for which it was first registered or approved, or which replace them.. Article 17. Exemption from on-site visits. 1. Member States are exempted from the obligation to carry out on-site visits, as provided for in Article 13, of feed businesses which act solely as traders, without holding the products on their premises.. 2. Such feed businesses shall submit to the competent authority a declaration, in a form decided upon by the competent authority, to the effect that the feeds placed on the market by them comply with the conditions of this Regulation.. Article 18. Transitional measures. 1. Establishments and intermediaries approved and/or registered in accordance with Directive 95/69/EC may continue their activities, on condition that they ...
coccidiostats and histomonostats. The use of antibiotics as feed additives were previously permitted, but their use - other ... than coccidiostats and histomonostats - have since been prohibited.. Authorised additives. All authorised feed additives are ...
Highlighting the Importance of Detecting Coccidiostat Drug Residues. 15 January 2016. IPPE: More Than 25,000 Attendees, 1,189 ...
Coccidiostat. FOR ORAL USE IN ANIMALS ONLY. KEEP THIS AND ALL DRUGS OUT OF REACH OF CHILDREN ...
... coccidiostat; cognition adjuvant; depressant; diuretic; dopaminergic agent; ectoparasiticide; emetic; enzyme inhibitor; ...
Coccidiostat. FOR ANIMAL USE ONLY. KEEP THIS AND ALL DRUGS OUT OF REACH OF CHILDREN ...
Advance™ Replacer with Coccidiostat Item #622301 - In Stock Milk replacer for lambs and kids. Formulated with a coccidiostat. ...
Advance™ Replacer with Coccidiostat Item #622301 - In Stock Milk replacer for lambs and kids. Formulated with a coccidiostat. ...
... coccidiostat agents; cognition adjuvants and cognition enhancers; cough and cold preparations, including decongestants; ...
Antibiotics and coccidiostats 600 euro. Bovine urine. Resorcylic acid lactones. EURL PT, free of charge for NRLs. 600 euro. ...
  • To study the effect of coccidiosis on different blood parameters and its therapeutic trials, a total of 180 quails of 2 weeks old were reared on coccidiostat free feed and of these 150 were experimentally induced with coccidiosis. (thefreedictionary.com)
  • Effect of herbal coccidiostat on pathology of coccidiosis in broilers. (fao.org)
  • Coccidiostats are animal feed additives used to prevent coccidiosis by inhibiting or killing coccidia. (who.int)
  • Corid 9.6% Oral Solution Coccidiostat (Amprolium) for use as an aid in the prevention and treatment of coccidiosis in calves. (valleyvet.com)
  • With this study we found massive usage of coccidiostat in the region even though its usage cannot guarantee coccidiosis-free chicken production. (hindawi.com)
  • It is best prevented by feeding a coccidiostat, which is a drug added to feed at low levels and fed continuously to prevent coccidiosis. (agriculture.com)
  • Corid ® 9.6% Oral Solution is the only coccidiostat labeled for both treatment and prevention of coccidiosis caused by Eimeria bovis and E. zuernii in calves. (revivalanimal.com)
  • Coccidiosis can be prevented with a number of coccidiostats or treated in its early stages. (ndsu.edu)
  • Coccidiostats is used to treat coccidiosis, a parasitic disease which comes from living in waste. (animal-lib.org.au)
  • Treatment is amprolium or a similar coccidiostat. (backyardchickens.com)
  • Examples of coccidiostats added to the ration include Monensin sodium, Lasalocid, Amprolium, and Salinomycin. (agriculture.com)
  • Any coccidiostat, including amprolium, will nullify the vaccine. (backyardchickens.com)
  • The use of antibiotics as feed additives were previously permitted, but their use - other than coccidiostats and histomonostats - have since been prohibited. (food.gov.uk)
  • Coccidiostats and/or antibiotics are the two most common medications added to feeds. (agriculture.com)
  • Calves are treated with antibiotics, coccidiostats or dewormers. (dairystar.com)
  • There's a class of antibiotics called ionophores and another group of medicines called non-antibiotic coccidiostats (not antibiotics) which are used to prevent this disease. (nationalchickencouncil.org)
  • Most chickens are given an ionophore or a non-antibiotic coccidiostat for an FDA-approved duration to prevent this intestinal disease, thus preventing the overuse of potentially medically important antibiotics in treatment of sick birds. (nationalchickencouncil.org)
  • Free-ranging chickens can be treated with therapeutic antibiotics under veterinary direction and sold with the use of coccidiostats [a chemical agent added to animal feed]', Sally, author of Eat Yourself Healthy in 28 Days , tells news.com.au. (news.com.au)
  • Just because a chicken roams free, doesn't mean it's not fed antibiotics, supplements, or coccidiostats', a representative for Inglewood Farms Organic, tells news.com.au. (news.com.au)
  • What is clear is that organic birds are raised without the use of antibiotics, hormones or coccidiostats and the ration is also guaranteed free of chemicals, herbicides and fertilisers. (news.com.au)
  • 12 October 2010 - Residues of the coccidiostat nicarbazin have been detected by the Italian authorities in samples taken from a 24.9 ton shipment of frozen poultry meat from Brazil. (thefreedictionary.com)
  • The intensification of poultry has made necessary to use chemical coccidiostats, due to the great productive effort to which birds are subjected. (veterinariadigital.com)
  • Consequently, some bacterial infections may also be controlled by ionophore coccidiostats, e.g. the poultry disease necrotic enteritis caused by the bacterium Clostridium perfringens (C. perfringens). (who.int)
  • Nicarbazin is presently registered for use as a coccidiostat for poultry. (jove.com)
  • Evaluation of herbal coccidiostat 'Coxynil' in broiler. (bvsalud.org)
  • The results indicate that Coxynil is effective herbal coccidiostat. (bvsalud.org)
  • ionophores and non-ionophores, the latter also referred to as "non-ionophore coccidiostats" (but also called chemicals). (who.int)
  • One main difference between these groups is that ionophores also inhibit or kill some bacterial species, whereas non-ionophore coccidiostats do not. (who.int)
  • Eleven different coccidiostats have been authorised for use in the EU, both ionophores and non-ionophore coccidiostats. (who.int)
  • The two ionophore coccidiostats currently used in Norway are narasin for broilers and monensin for turkeys. (who.int)
  • Cross-resistance between various ionophore coccidiostats has also been shown, i.e. development of resistance to one ionophore may also render the coccidia resistant to another ionophore. (who.int)
  • Various rotation and shuttle programmes with exchange between ionophores and non-ionophore coccidiostats are believed to prevent or delay development of resistance in coccidia. (who.int)
  • In Norway, such programmes will have little effect as long as only ionophores and not non-ionophore coccidiostats are approved for use. (who.int)
  • Non-ionophore coccidiostats, which do not have antibacterial effect, are not approved in Norway. (who.int)
  • Note that ionophore coccidiostats can improve feed conversion if delivered in an appropriate range. (gov.on.ca)
  • A coccidiostat is an antiprotozoal agent that acts upon Coccidia parasites. (wikipedia.org)
  • Resistance to coccidiostats in coccidia and bacteria: Development of resistance in coccidia to all eleven coccidiostats has been described in the scientific literature, but the prevalence of resistance is unknown. (who.int)
  • The coccidiostat ties up thiamine, making the coccidia unable to reproduce. (extension.org)
  • Several samples of feed have tested positive for Coccidiostats/Nicarbazin and Salinomycin. (animal-lib.org.au)
  • I en studie fra Canada hvor kyllingene fikk ulike antibiotika, blant annet narasin, heter det: «Our study clearly shows that broiler chickens act as a reservoir for commensal E. coli strains carrying large numbers of antibiotic resistance genes. (tidsskriftet.no)
  • Are ionophores and non-antibiotic coccidiostats used to promote growth in chickens? (nationalchickencouncil.org)
  • Artimesia annua acted as botanical coccidiostat in affected broilers. (thefreedictionary.com)
  • Use of Artemisia annua as a natural coccidiostat in free-range broilers and its effects on infection dynamics and performance Source. (thefreedictionary.com)
  • Feed broilers a ration containing a coccidiostat until the last week before slaughtering. (agriculture.com)
  • In contrast to broiler and layer examined, farmers usually use coccidiostat in feed during layer and growing/fattening period of local chicken. (thefreedictionary.com)
  • It is important to note that ionophores and non-antibiotic coccidiostats are not used in human medicine. (nationalchickencouncil.org)
  • Duan, "Development of a rapid LC-MS-MS method for multi-class determination of 14 coccidiostat residues in eggs and chicken," Chromotographia, vol. (thefreedictionary.com)
  • For the detection of coccidiostat drug residues, Biochip Array Technology (BAT) has been identified as an industry leader. (thepoultrysite.com)
  • Salinomycin is an antibacterial and coccidiostat ionophore therapeutic drug. (wikipedia.org)
  • Salinomycin is used in chicken fodder as a coccidiostat . (wikipedia.org)
  • It was effective as a feed additive and coccidiostat. (fao.org)
  • Both the coccidiostats used in the study delayed the appearance of clinical symptoms as compared to infected control group (IA). (fao.org)
  • Heavily infected animals that show severe clinical signs and coccidiostat resistance are causing important economic losses. (hindawi.com)
  • ILVO has received BELAC accreditation for detection of coccidiostats in eggs, meat and feed. (vlaanderen.be)
  • Evaluate the effect of intestinal optimizer pronutrients to replace chemical coccidiostats and at the same time the effect of liver conditioning pronutrients on production parameters. (veterinariadigital.com)
  • The combined use of intestinal optimizer pronutrients and liver conditioning pronutrients can decrease mortality, especially in the early stages of growth, and decrease the feed conversion rate promoting the use of feed, thus constituting an effective alternative to chemical coccidiostats. (veterinariadigital.com)
  • If such coccidiostats were approved in Norway, coccidiostats with negligible probability of inducing resistance in bacteria would be available. (who.int)
  • Consider including a milk fortifier with a coccidiostat and trace minerals. (oregonstate.edu)
  • De-wormers will not be effective, a coccidiostat must be used. (scribd.com)
  • Birds raised for placement in the laying flocks are fed a coccidiostat feed until about 16 weeks of age. (agriculture.com)
  • There are chick feed mixes that contain a coccidiostat to manage exposure levels and control disease. (thefreedictionary.com)
  • Despite the efforts taken by the feed companies to avoid any cross-contamination, as imposed by European directive 2005/183/EC, maximum levels of coccidiostat carryover have been set (2009/8/CE) to protect animal health and guarantee minimal risk to the consumers. (waters.com)
  • Therapeutic dose, carry-over levels, and required LOQ for the 11 coccidiostats. (waters.com)
  • Global Coccidiostat Market Report provides main statistics connected to the overall market and value forecast over a period, from 2019 to 2028. (wn.com)
  • A fast, robust, accurate, and sensitive method for 11 coccidiostats in feed samples was developed on an ACQUITY UPLC I-Class System with Xevo TQ-S. (waters.com)