Agents useful in the treatment or prevention of COCCIDIOSIS in man or animals.
Drugs used by veterinarians in the treatment of animal diseases. The veterinarian's pharmacological armamentarium is the counterpart of drugs treating human diseases, with dosage and administration adjusted to the size, weight, disease, and idiosyncrasies of the species. In the United States most drugs are subject to federal regulations with special reference to the safety of drugs and residues in edible animal products.
Drugs and their metabolites which are found in the edible tissues and milk of animals after their medication with specific drugs. This term can also apply to drugs found in adipose tissue of humans after drug treatment.
Protozoan infection found in animals and man. It is caused by several different genera of COCCIDIA.
Domesticated birds raised for food. It typically includes CHICKENS; TURKEYS, DUCKS; GEESE; and others.
A genus of protozoan parasites of the subclass COCCIDIA. Various species are parasitic in the epithelial cells of the liver and intestines of man and other animals.
Diseases of birds which are raised as a source of meat or eggs for human consumption and are usually found in barnyards, hatcheries, etc. The concept is differentiated from BIRD DISEASES which is for diseases of birds not considered poultry and usually found in zoos, parks, and the wild.
The collective designation of three organizations with common membership: the European Economic Community (Common Market), the European Coal and Steel Community, and the European Atomic Energy Community (Euratom). It was known as the European Community until 1994. It is primarily an economic union with the principal objectives of free movement of goods, capital, and labor. Professional services, social, medical and paramedical, are subsumed under labor. The constituent countries are Austria, Belgium, Denmark, Finland, France, Germany, Greece, Ireland, Italy, Luxembourg, Netherlands, Portugal, Spain, Sweden, and the United Kingdom. (The World Almanac and Book of Facts 1997, p842)
Activities involved in ensuring the safety of FOOD including avoidance of bacterial and other contamination.
A publication issued at stated, more or less regular, intervals.
A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
Foodstuff used especially for domestic and laboratory animals, or livestock.
The composition of a committee; the state or status of being a member of a committee.
A group of SESQUITERPENES and their analogs that contain a peroxide group (PEROXIDES) within an oxepin ring (OXEPINS).
Agents used in the treatment of malaria. They are usually classified on the basis of their action against plasmodia at different stages in their life cycle in the human. (From AMA, Drug Evaluations Annual, 1992, p1585)
A family of diphenylenemethane derivatives.
A republic in central Africa lying east of CHAD and the CENTRAL AFRICAN REPUBLIC and west of NIGERIA. The capital is Yaounde.
Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations.
Single preparations containing two or more active agents, for the purpose of their concurrent administration as a fixed dose mixture.
A 4-aminoquinoline compound with anti-inflammatory properties.
Detailed account or statement or formal record of data resulting from empirical inquiry.
Databases containing information about PROTEINS such as AMINO ACID SEQUENCE; PROTEIN CONFORMATION; and other properties.
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
The portion of an interactive computer program that issues messages to and receives commands from a user.
Sequential operating programs and data which instruct the functioning of a digital computer.
Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.
An NADPH-dependent enzyme that catalyzes the conversion of L-ARGININE and OXYGEN to produce CITRULLINE and NITRIC OXIDE.
A class of enzymes that catalyze oxidation-reduction reactions of amino acids.
A CALCIUM-dependent, constitutively-expressed form of nitric oxide synthase found primarily in ENDOTHELIAL CELLS.
Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
Compounds that inhibit HMG-CoA reductases. They have been shown to directly lower cholesterol synthesis.
A CALCIUM-independent subtype of nitric oxide synthase that may play a role in immune function. It is an inducible enzyme whose expression is transcriptionally regulated by a variety of CYTOKINES.
Disorders affecting the motor function of the UPPER ESOPHAGEAL SPHINCTER; LOWER ESOPHAGEAL SPHINCTER; the ESOPHAGUS body, or a combination of these parts. The failure of the sphincters to maintain a tonic pressure may result in gastric reflux of food and acid into the esophagus (GASTROESOPHAGEAL REFLUX). Other disorders include hypermotility (spastic disorders) and markedly increased amplitude in contraction (nutcracker esophagus).
An application that must be submitted to a regulatory agency (the FDA in the United States) before a drug can be studied in humans. This application includes results of previous experiments; how, where, and by whom the new studies will be conducted; the chemical structure of the compound; how it is thought to work in the body; any toxic effects found in animal studies; and how the compound is manufactured. (From the "New Medicines in Development" Series produced by the Pharmaceutical Manufacturers Association and published irregularly.)
Substances made up of an aggregation of small particles, as that obtained by grinding or trituration of a solid drug. In pharmacy it is a form in which substances are administered. (From Dorland, 28th ed)
The medical science concerned with the prevention, diagnosis, and treatment of diseases in animals.
An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.
A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precursors of certain vitamins, bile acids, alcohols (STEROLS), and certain natural drugs and poisons. Steroids have a common nucleus, a fused, reduced 17-carbon atom ring system, cyclopentanoperhydrophenanthrene. Most steroids also have two methyl groups and an aliphatic side-chain attached to the nucleus. (From Hawley's Condensed Chemical Dictionary, 11th ed)
A device that delivers medication to the lungs in the form of a dry powder.
Food products manufactured from poultry.
Individuals enrolled in a school of pharmacy or a formal educational program leading to a degree in pharmacy.
Formal instruction, learning, or training in the preparation, dispensing, and proper utilization of drugs in the field of medicine.
A milky, product excreted from the latex canals of a variety of plant species that contain cauotchouc. Latex is composed of 25-35% caoutchouc, 60-75% water, 2% protein, 2% resin, 1.5% sugar & 1% ash. RUBBER is made by the removal of water from latex.(From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed). Hevein proteins are responsible for LATEX HYPERSENSITIVITY. Latexes are used as inert vehicles to carry antibodies or antigens in LATEX FIXATION TESTS.
A plant genus of the family EUPHORBIACEAE, order Euphorbiales, subclass Rosidae. Commercial natural RUBBER is mainly obtained from Hevea brasiliensis but also from some other plants.
A high-molecular-weight polymeric elastomer derived from the milk juice (LATEX) of HEVEA brasiliensis and other trees and plants. It is a substance that can be stretched at room temperature to at least twice its original length and after releasing the stress, retract rapidly, and recover its original dimensions fully.
Passive agglutination tests in which antigen is adsorbed onto latex particles which then clump in the presence of antibody specific for the adsorbed antigen. (From Stedman, 26th ed)
MAMMARY GLANDS in the non-human MAMMALS.
Infections with bacteria of the family PASTEURELLACEAE.

Salinomycin-induced polyneuropathy in cats: morphologic and epidemiologic data. (1/100)

In April 1996, an outbreak of toxic polyneuropathy in cats occurred in the Netherlands. All cats had been fed one of two brands of dry cat food from one manufacturer. Chemical analyses of these foods, stomach contents, and liver and kidney of affected cats revealed contamination with the ionophor salinomycin. Epidemiologic and clinical data were collected from 823 cats, or about 1% of the cats at risk. In 21 affected cats, postmortem examination was performed. The affected cats had acute onset of lameness and paralysis of the hindlimbs followed by the forelimbs. Clinical and pathologic examination indicated a distal polyneuropathy involving both the sensory and motor nerves.  (+info)

In-vitro activity of polycationic peptides against Cryptosporidium parvum, Pneumocystis carinii and yeast clinical isolates. (2/100)

The in-vitro activity of magainin II, indolicidin and ranalexin against 14 clinical isolates of eukaryotic microorganisms was evaluated. Antifungal susceptibility testing was performed by broth microdilution, and activity against Pneumocystis carinii and Cryptosporidium parvum was determined by inoculation on to cell monolayers. For yeasts, peptide MICs and MFCs ranged from 6.25 to > 50 mg/L. Ranalexin showed the highest activity against Candida spp., while magainin II demonstrated greatest anticryptococcal activity. The peptides suppressed the growth of P. carinii by > or = 50% and > or = 90% at 5 and 50 microM, respectively, with the exception of indolicidin. Ranalexin, the most effective compound against C. parvum, suppressed its growth by > or = 40% at 50 microM.  (+info)

Anticryptosporidial activity of ranalexin, lasalocid and azithromycin alone and in combination in cell lines. (3/100)

The in vitro anticryptosporidial activities of ranalexin, lasalocid and azithromycin alone and in combination were investigated against four clinical isolates of Cryptosporidium parvum. Susceptibility was tested by inoculating the isolates on to cell monolayers and determining the parasite count after 48 h incubation at 37 degrees C. The culture medium was supplemented with Dulbecco's modified Eagle's medium containing serial dilutions of the above-mentioned compounds. Ranalexin showed moderate anticryptosporidial activity: at a concentration of 64 mg/L it reduced parasite counts by 33.8%. Azithromycin at a concentration of 8 mg/L gave inhibition comparable to that observed with the highest concentration of ranalexin. Lasalocid showed the highest activity, with a 70.3% reduction in parasite counts at 2 mg/L. The combination of ranalexin 64 mg/L and lasalocid 2 mg/L completely suppressed parasite growth without harming the monolayer.  (+info)

Anti-toxoplasma activities of antiretroviral drugs and interactions with pyrimethamine and sulfadiazine in vitro. (4/100)

The anti-Toxoplasma activities of nine antiretroviral drugs were examined in vitro. Nucleoside analogs had no effect on parasite growth, whereas ritonavir and nelfinavir were inhibitory for Toxoplasma, with 50% inhibitory concentrations of 5.4 and 4.0 microg/ml, respectively. None of the antiviral drugs affected the anti-Toxoplasma activity of pyrimethamine or sulfadiazine.  (+info)

Recent advances in biology and immunobiology of Eimeria species and in diagnosis and control of infection with these coccidian parasites of poultry. (5/100)

Avian coccidiosis, an intestinal disease caused by protozoan parasites of the genus Eimeria, occurs worldwide. It is considered to be one of the most economically important diseases of domestic poultry. For many years, prophylactic use of anticoccidial feed additives has been the primary means of controlling coccidiosis in the broiler industry and has played a major role in the growth of this industry, which now can produce about 7.6 billion chickens annually. However, development of anticoccidial resistance has threatened the economic stability of the broiler industry. Although there has been little effort by the pharmaceutical industry to develop new anticoccidials, the mounting problem of drug resistance of Eimeria species has prompted major research efforts to seek alternative means of control through increased knowledge of parasite biology, host response, and nutritional modulation. As a consequence, important advancements have been made, particularly in defining parasite antigens that have potential use in vaccines, defining the Eimeria genome, understanding the immunology of coccidial infections, and the practical applications of live vaccines. This review describes the progress in these areas, most of which has occurred within the past 10 to 15 years.  (+info)

Disruption of microtubules uncouples budding and nuclear division in Toxoplasma gondii. (6/100)

The tachyzoite stage of the protozoan parasite Toxoplasma gondii has two populations of microtubules: spindle microtubules and subpellicular microtubules. To determine how these two microtubule populations are regulated, we investigated microtubule behavior during the cell cycle following treatment with microtubule-disrupting drugs. Previous work had established that the microtubule populations are individually nucleated by two distinct microtubule-organizing centers (MTOCs): the apical polar ring for the subpellicular microtubules and spindle pole plaques/centrioles for the spindle microtubules. When replicating tachyzoites were treated with 0.5 microM oryzalin or 1.0 mM colchicine they retained the capacity to form a spindle and undergo nuclear division. Although these parasites could complete budding, they lost the bulk of their subpellicular microtubules and the ability to reinvade host cells. Both nascent spindle and subpellicular microtubules were disrupted in 2.5 microM oryzalin or 5.0 mM colchicine. Under these conditions, parasites grew in size and replicated their genome but were incapable of nuclear division. After removal from 0.5 microM oryzalin, Toxoplasma tachyzoites were able to restore normal subpellicular microtubules and a fully invasive phenotype. When oryzalin was removed from Toxoplasma tachyzoites treated with 2.5 microM drug, the parasites attempted to bud as crescent-shaped tachyzoites. Because the polyploid nuclear mass could not be correctly segregated, many daughter parasites lacked nuclei altogether although budding and scission from the maternal mass was able to be completed. Multiple MTOCs permit Toxoplasma tachyzoites to control nuclear division independently from cell polarity and cytokinesis. This unusual situation grants greater cell cycle flexibility to these parasites but abolishes the checks for coregulation of nuclear division and cytokinesis found in other eukaryotes.  (+info)

Effect of wean-to-finish management on pig performance. (7/100)

In each of three trials, 240 crossbred barrows weaned at 17 d of age (5.1 kg BW) were assigned to one of three experimental treatments based on light and heavy weight outcome groups. Experimental treatments were 1) wean-to-finish at 0.69 m2/pig and 15 pigs/pen; 2) wean-to-finish double-stocked at 0.35 m2/pig, 30 pigs per pen for 8 wk and then randomly split into two pens (either stayed in same pen or moved to new pen) for growth to slaughter at 0.69 m2/pig; and 3) nursery facility for 8 wk at 0.35 m2/pig and 15 pigs/pen followed by move to the same grow-finish facility housing wean-to-finish and double-stocked pigs and maintaining pen integrity. Beginning at 38 kg BW, diets were supplemented with either bacitracin methylenedisalicylate at 33 mg/kg to slaughter or tylosin at 44 mg/kg to 59 kg BW and 22 mg/kg thereafter. There were no trial x treatment interactions, even though there was considerable variation in health status among trials. At the end of the 56-d nursery period, wean-to-finish pigs weighed more than nursery (28.7 vs 27.7 kg; P = 0.071) and double-stocked pigs (28.7 vs 26.9 kg; P = 0.002), due to greater ADG (wean-to-finish vs nursery; P = 0.062; wean-to-finish vs double-stocked; P = 0.002) and greater ADFI (wean-to-finish vs nursery; P = 0.024; wean-to-finish vs double-stocked, P = 0.002). There was no effect of treatments (P > 0.1) on ADG, feed conversion, carcass lean percentage, or lean gain during the growing-finishing period. There was also no effect of treatment (P > 0.1) on ADG or ADFI from weaning to slaughter. There was no difference (P > 0.1) between bacitracin methylenedisalicylate and tylosin for ADG, feed conversion, carcass lean percentage, or daily lean gain. These data suggest that housing 5-kg weaned pigs in fully slatted growing-finishing facilities from weaning to slaughter was not detrimental to overall performance. In this experiment, dietary additions of bacitracin methylenedisalicylate or tylosin from 38 kg BW to slaughter weight resulted in similar growth performance.  (+info)

Efficacy of common laboratory disinfectants on the infectivity of Cryptosporidium parvum oocysts in cell culture. (8/100)

Nine liquid disinfectants were tested for their ability to reduce infectivity of Cryptosporidium parvum oocysts in cell culture. A 4-min exposure to 6% hydrogen peroxide and a 13-min exposure to ammonium hydroxide-amended windshield washer fluid reduced infectivity 1,000-fold. Other disinfectants tested (70% ethanol, 37% methanol, 6% sodium hypochlorite, 70% isopropanol, and three commercial disinfectants) did not reduce the infectivity after a 33-min exposure. The results indicate that hydrogen peroxide and windshield washer fluid or ammonium hydroxide disinfectant may be suitable laboratory disinfectants against C. parvum oocysts.  (+info)

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2000-6-8 · Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) is a relatively new technique that is having a great impact on analyses. This study is the first to demonstrate the use of linear MALDI-TOF MS to identify and quantify coccidiostats in poultry feeds. 2,5-Dihydroxybenzoic acid (DHB) was found to be the best matrix. In MALDI-TOF MS, coccidiostats form .... Get Price ...
[65 Pages Report] Check for Discount on [1,3-Bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene]bis(2-bromopyridine)dichloro(phenylmethylene)ruthenium Global Market and Forecast Research report by ChemReport. DescriptionWe provide independent and unbiased information on manufacturers, prices, production...
Dublin, May 12, 2021 (GLOBE NEWSWIRE) -- The Feed Additives Market: Global Industry Trends, Share, Size, Growth and Forecast 2021-2026 report has been added to ResearchAndMarkets.coms offering. The global feed additives market reached a value of US$ 37.1 Billion in 2020. Feed additives are nutritional supplements that are added to improve the quality of animal derived products such as meat, milk, eggs, etc. Feed additives usually consist of vitamins, minerals, amino acids and other essential nutrients that ensure optimum health of animals and prevent diseases. There are usually four types of feed additives administered to animal food such as sensory additives that stimulate animals appetite, nutritional additives that provide a particular nutrient to the animal, zootechnical additive that maintain the overall nutritional balance in the animals diet and coccidiostats that releases antibiotics killing any form of bacteria in the animals system.The global feed additives market is currently being
What are the symptoms?. In cats, it causes diarrhea. The stool is often highly liquid in consistency. You may also see blood in the stool, as they cause damage to the intestines. The cat may get dehydrated as a result of the diarrhea.. Is it serious?. Yes - a cat will get dehydrated from the diarrhea and may lose blood. It makes the pet very ill and susceptible to other infections, and sometimes they die if they get sick from something else at the same time. You need to take the pet to the vet, because it is easily treatable, but it can take a week for them to get over it. What is the treatment? There are a couple of treatments. Antibiotics are often used, as well as coccidiostats, which are medicines designed to help the cats immune system fight back specifically against coccidia. Keeping the cat hydrated is also very important. Albon is one of the most commonly used drugs against it. Is it contagious to other pets or to people?. Both dogs and cats can get the same kind of coccidia - but ...
Commission Implementing Regulation (EU) 2015/1105 of 8 July 2015 concerning the authorisation of a preparation of Bifidobacterium animalis ssp. animalis DSM 16284, Lactobacillus salivarius ssp. salivarius DSM 16351 and Enterococcus faecium DSM 21913 as a feed additive for chickens reared for laying and minor poultry species other than laying, the authorisation of that feed additive for use in water for drinking for chickens for fattening and amending Regulation (EU) No 544/2013 as regards the maximum content of that feed additive in complete feedingstuff and its compatibility with coccidiostats (holder of the authorisation Biomin GmbH ...
Coccidiostats are compounds that are widely used to prevent and treat coccidiosis. February 2014, Commission Implementing Regulation (EU) No 1235/2013 has come into...
Poultry feeds are available with several types of medications for preventing or treating diseases. Coccidiostats and/or antibiotics are the two most common medications added to feeds.
PROBOTIC 25G #VT00423 $20.00 PROBOTIC 90G #VT00054 $30.00. A concentrated water-soluble blend of 7 live microbes for use in drinking water or addition to food. Aids in the establishment of gastrointestinal micro flora in hand reared baby birds, day old chicks, puppies and kittens and other physiologically immature animals. Re-establishes natural gut flora after infections, diarrhoea, stress and the use of antibiotics. Recommended for: Baby birds being reared on a formula not produced by Vetafarm, birds recovering from illness or birds that have recently been treated with antibiotics. Probotic may be used during periods of extreme stress e.g.: overcrowding, diarrhoea, temperature extremes, transportation, training and medication; and following surgery.. Also suitable For: Dogs, Cats and Poultry Chicks. Can be used with: Probotic can be given in water or mixed in food. Probotic is compatible with feed ingredients including anthelmintics, coccidiostats, minerals and vitamins. Probotic® should NOT ...
गुणवत्ता दवा कच्चे माल निर्माताओं & निर्यातक - खरीदें White Diclazuril Raw Steroid Powders for Coccidiostat Animal Drug of Diclazuril CAS 101831-37-2 चीन से निर्माता.
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But even with greater flexibility, Stayer is worried about consistent product availability for the 11 million birds Sanderson Farms sends to market each week. In some cases, he added, theyve had to raise flocks without antibiotics - usually a non-ionophore anticoccidial or vaccine - if the ionophore they wanted was not immediately available.. It can work the other way, too, he said. Sometimes the rotation program calls for a non-ionophore anticoccidial or vaccine, but those products also get backordered.. When backorders happen, Stayer said, We can get by but its not going to be best. Hes also concerned that in some situations, flocks could suffer when disease-control options are compromised.. Stayer acknowledged that the surge in NAE production has probably made it more difficult for animal health companies to keep pace with the changing needs of the industry. At the same time, he expressed concern that the industrys move away from antibiotics could cause supplies of some feed medications ...
There statistically januvia generic cost is limited evidence to support the notion that alcoholic beverages, breads and other foods made with yeast can lead to yeast infections. The strain was initially phenotypically tetracycline resistant and carried the tet(A) gene! A administração deve começar o mais cedo possível. A broad-spectrum antibiotic powder for use in ornamental birds for bacterial infections? The coccidiostat added to poultry (hen) grower pellets is not a treatment! Remember, when Tretinoin is used properly, many users see improvement by 12 weeks? It prolongs, celebrex vs tramadol and helps sustain the penile erec! In general, phenergan elixir over the counter uk wholesomely dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy! However, it should be noted that their philological analysis ...
3-Bromo-n-[2-(dimethylamino)ethyl]benzamide; CAS Number: 425618-78-6; Linear Formula: C11H15BrN2O; find Combi-Blocks, Inc.-COMH93D5B863 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich
Classical treatment for congenital toxoplasmosis is based on combination of sulfadiazine and pyrimethamine plus folinic acid. Due to teratogenic effects and bone marrow suppression caused by pyrimethamine, the establishment of new therapeutic strategies is indispensable to minimize the side effects and improve the control of infection. Previous studies demonstrated that enrofloxacin and toltrazuril reduced the incidence of Neospora caninum and Toxoplasma gondii infection. The aim of the present study was to evaluate the efficacy of enrofloxacin and toltrazuril in the control of T. gondii infection in human trophoblast cells (BeWo line) and in human villous explants from the third trimester. BeWo cells and villous were treated with several concentrations of enrofloxacin, toltrazuril, sulfadiazine, pyrimethamine, or combination of sulfadiazine+pyrimethamine, and the cellular or tissue viability was verified. Next, BeWo cells were infected by T. gondii (2F1 clone or the ME49 strain), whereas villous
At a press conference yesterday in Belgium, Maja Mariën of Alpharma Animal Health explained the new approach of fighting coccidiosis in poultry. The main message: rotate the use of different coccidiostats!
(1H-Indazol-3-yl)methanol 64132-13-4 NMR spectrum, (1H-Indazol-3-yl)methanol H-NMR spectral analysis, (1H-Indazol-3-yl)methanol C-NMR spectral analysis ect.
Toxoplasma gondii is a ubiquitous apicomplexan parasite capable of infecting humans and other animals. Current treatment options for T. gondii infection are limited and most have drawbacks, including high toxicity and low tolerability. Additionally, no FDA-approved treatments are available for pregnant women, a high-risk population due to transplacental infection. Therefore, the development of novel treatment options is needed. To aid this effort, this review highlights experimental compounds that, at a minimum, demonstrate inhibition of in vitro growth of T. gondii When available, host cell toxicity and in vivo data is also discussed. The purpose of this review is to facilitate additional development of anti-Toxoplasmacompounds, and potentially to extend our knowledge of the parasite ...
Acquiring therapy resistance is one of the major obstacles in the treatment of patients with cancer. The discovery of the cancer stem cell (CSC)-specific drug salinomycin raised hope for improved treatment options by targeting therapy-refractory CSCs and mesenchymal cancer cells. However, the occurrence of an acquired salinomycin resistance in tumor cells remains elusive. To study the formation of salinomycin resistance, mesenchymal breast cancer cells were sequentially treated with salinomycin in an in vitro cell culture assay, and the resulting differences in gene expression and salinomycin susceptibility were analyzed. We demonstrated that long-term salinomycin treatment of mesenchymal cancer cells resulted in salinomycin-resistant cells with elevated levels of epithelial markers, such as E-cadherin and miR-200c, a decreased migratory capability, and a higher susceptibility to the classic chemotherapeutic drug doxorubicin. The formation of salinomycin resistance through the acquisition of ...
4-fluoro-1H-indazol-3-amine; CAS Number: 404827-78-7; Linear Formula: C7H6FN3; find Key Organics / BIONET-KEY158583413 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich
Collectively our data demonstrate that the lethality of low nanomolar concentrations of salinomycin are enhanced by HDAC inhibitors in GBM cells and that increased death receptor signaling together with reduced mitochondrial function are causal in the combinatorial drug necro-apoptotic killing effect.. Salinomycin induces cell death with autophagy through activation of endoplasmic reticulum stress in human cancer cells. In conclusion, these findings provide evidence that combination treatment with salinomycin and pharmacological autophagy inhibitors will be an effective therapeutic strategy for eliminating cancer cells as well as cancer stem cells.. Salinomycin enhances doxorubicin-induced cytotoxicity in multidrug resistant MCF-7/MDR human breast cancer cells via decreased efflux of doxorubicin.. Salinomycin decreases doxorubicin resistance in hepatocellular carcinoma cells by inhibiting the β-catenin/TCF complex association via FOXO3a activation.. Salinomycin inhibits growth of pancreatic ...
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Solvent Extraction Burnley - EVS Ltd design and install LEV systems required for solvent extraction to ensure airborne emissions are controlled.
|p|Silia|em||span style=color: #46423c;|Chrom|/span||/em||sup|®|/sup| XDB1 C18 column has the highest loading density available as well as the highest hydrophobicity. This allows it to have the least interactions between the analytes and potential r
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
EVS Ltd specialise in the design and installation of LEV systems required for solvent extraction to ensure airborne emissions are contained and controlled.
Coccidiosis is caused in chickens by the genus Eimeria spp, and is considered as one of the dominant poultry diseases worldwide. For decades, anticoccidial products have been used for the successful control of this disease. However, long term use of these products has led to the development of resistance. The current study therefore sought to investigate the anticoccidial activity of the methanol leaf extract of Lannea schimperi on experimentally induced Eimeria tenella (E. tenella) infection in broiler chickens in an attempt to provide good alternative therapy due to increasing resistance to the conventional anticoccidial agents. Seven groups (A-G) of 4 birds were used for the experiment and five groups (A-E) were orally inoculated with 1.0 x 103 sporulated oocysts of E. tenella. Groups A, B and C were treated with 25, 50 and 100 mg/kg body weight of L. schimperi methanolic leaf extract respectively and Group D was treated with1.5 mg/ml of amprolium, group E served as negative control. Groups F and G
As the worlds poultry production continues to grow, so do concerns about the control of Eimeria infections that cause coccidiosis, which remains one of the most commonly reported diseases of chickens. The ubiquity of chicken Eimeria precludes eradication so the key role in control of the disease is played by hygiene, anticoccidial drugs and vaccines.. Nowadays there is pressing need to move away from chemotherapeutic control of coccidiosis towards vaccination due to different reasons: resistance developed by coccidia to most of the anticoccidial drugs in the market, concerns about drug residues in poultrys products and strong desires of consumers to ban drugs from animal feeds.. Coccidiosis vaccines basically are divided in: live vaccines and inactivated vaccines, but actually for coccidia there is only one inactivated vaccine in the market and it is registered only in few countries. Live oocyst vaccines differ in many ways, such as the type of Eimeria species (virulent vs. attenuated), the ...
Background: Antimicrobial resistance and antimicrobial stewardship are of ever-increasing importance in veterinary medicine. Re-purposing of old drugs that are not used in human medicine is one approach that addresses the emergence of multidrug resistance in canine skin and ear infections, and can reduce the use of critically important human antibiotic classes. Hypothesis/Objectives: To determine the antimicrobial activity of narasin, a polyether ionophore conventionally used as a rumen modifier and anticoccidial agent in production animals, against common clinical isolates of canine otitis externa (OE). Animals/Isolates: Clinical isolates (n = 110) from canine OE were tested, including 17 meticillin-susceptible Staphylococcus pseudintermedius (MSSP), 13 multidrug-resistant Staphylococcus pseudintermedius (MDRSP), and 20 each of β-haemolytic Streptococcus spp., Pseudomonas aeruginosa, Proteus mirabilis and Malassezia pachydermatis. Methods: Bacterial and yeast isolates were subcultured, ...
Coccidia is found everywhere, its … Continue this treatment monthly until the kids are 6-7 month old. Apart from the high mortality that can be caused by coccidiosis, affected kids that do not die, suffer a serious setback, which usually results in stunted growth and also lowers their resistance to … Additionally, Lactated Ringers Solution (an inexpensive vet prescription that you should never be without) should be given under the skin (SQ) at both shoulders warmed to appropriate temperature -- dose 30 cc per shoulder SQ for kids. Coccidiosis in goats can cause ill thrift, severe diarrhoea and sometimes death. Keep refrigerated. Baytril 100 is available both in injectable and tablet form, but the oral treatment seems to work faster in the gut of the goat. The best preventive measure a goat producer can take is to use a feed with a coccidiostat added. The problem with using a feed with coccidiostat is that you cant be sure how much medication each of the kids are taking in. The parasite ...
GLOBAL - The poultry industry has highlighted coccidiosis as one of the most prevalent factors adversely affecting producers and processors globally.
Salinomycin is a monocarboxylic polyether ionophore isolated from Streptomyces albus that has been used for more than 30 years as an agricultural antibiotic to prevent coccidiosis in poultry and to improve nutrient absorption and feed efficiency in ruminants and swine. As a inonophore with strict selectivety for alkali ions and a strong preference for potassium, salinomycin interferes with transmembrane potassium potential and promotes the efflux of K+ ions from mitochondria and cytoplasm. Salinomycin has recently been shown to kill human cancer stem cells and to inhibit breast cancer growth and metastasis in mice. Salinomycin is also able to induce massive apoptosis in human cancer cells of different origins that display multiple mechanisms of drug and apoptosis resistance. Salinomycin activates an unconventional pathway of apoptosis in human cancer cells that may contribute to the breakdown of apoptosis resistance. The ability of salinomycin to effectively kill both cancer stem cells and ...
Background: Tumor spreading is the major threat for cancer patients. The recently published anti-cancer drug salinomycin raised hope for an improved treatment by targeting therapy-refractory cancer stem cells. However, an unambiguous role of salinomycin against cancer cell migration and metastasis formation remains elusive. Findings: We report that salinomycin effectively inhibits cancer cell migration in a variety of cancer types as determined by Boyden chamber assays. Additionally, cells were treated with doxorubicin at a concentration causing a comparable low cytotoxicity, emphasizing the anti-migratory potential of salinomycin. Moreover, single-cell tracking by time-lapse microscopy demonstrated a remarkable effect of salinomycin on breast cancer cell motility. Ultimately, salinomycin treatment significantly reduced the metastatic tumor burden in a syngenic mouse tumor model. Conclusions: Our findings clearly show that salinomycin can strongly inhibit cancer cell migration independent of the ...
A 10-aa-long sequence in SLP-76 upstream of the Gads binding site is essential for T cell development and function. Prior to sampling, special considerations need to be addressed cialis side effects dangers related to various factors including current medications, health status, and hygiene practices. Coherent spike activity occurs between widely separated retinal cialis price ganglion cells (RGCs) in response to a large, contiguous object, but not to disjointed objects. 3D-CRT is an effective method in the treatment of patients with small primary hepatocellular carcinoma. Candida tropicalis was the only ascomycetous species isolated from all four sites.. We report 4 patients with retinal hemorrhages that developed during hospitalization for dengue fever. from common mynah (Acridotheres tristis) and preliminary survey of two anticoccidial drugs in natural cialis samples request infection. Experimental results on two benchmark datasets show the effectiveness of the proposed method and its ...
CAS No: 2374153-25-8 | 1-(Tetrahydro-2h-pyran-2-yl)-5-(trifluoromethyl)-1h-indazol-4-ylboronic acid | MDL Number: MFCD30609549 | Apollo Scientific
Structure, properties, spectra, suppliers and links for: 4-[(4-Acetyl-1-piperazinyl)carbonyl]-1-(4-fluoro-2H-indazol-3-yl)-2-pyrrolidinone.
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5-Bromo-N-(3-iodophenyl)-1,3-benzothiazol-2-amine | C13H8BrIN2S | CID 43304997 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
Benzamide, 4-bromo-N-(1H-indol-3-ylphenylmethyl)-N-phenyl- | C28H21BrN2O | CID 71399214 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
You are viewing an interactive 3D depiction of the molecule 2-bromo-n-{(1e,4e)-3-methyl-4-[(phenylsulfonyl)imino]-2,5-cyclohexadien-1-ylidene}acetamide (C15H13BrN2O3S) from the PQR.
With the successful sales of its feed additives sourced from Biomin, Zintec Feed Supplements has decided to set up a stand alone division: Zintec Feed Solutions. This new division will be responsible for the distribution of feed additives to the feed industry.
Global animal feed additive market stood at $14 billion in 2012 and is expected to grow at a CAGR of 4% to $19 billion by 2020. Learn more about research focus area and patents fillings activity of animal feed additive market.
Feed additive are the functional ingredients added to the feed to aid healthy growth of animals. There are various types of feed additives catering to a...
1140 agribusiness professionals from across the globe provided their views on the use of phytogenic feed additives (PFAs, or botanicals) as part of the 2017 BIOMIN Phytogenic Feed Additives Survey.
1140 agribusiness professionals from across the globe provided their views on the use of phytogenic feed additives (PFAs, or botanicals) as part of the 2017 BIOMIN Phytogenic Feed Additives Survey.
NOR/310R0885.ohfo OJ L 265/10, p. 5-8 COMMISSION REGULATION (EU) No 885/2010 of 7 October 2010 concerning the authorisation of the preparation of narasin and nicarbazin as a feed additive for chickens
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... the permanent authorisations of certain additives in feedingstuffs and an authorisation for 10 years for a coccidiostat ...
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