The combination of two or more different factors in the production of cancer.
Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.
The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.
Relating to the size of solids.
A set of statistical methods used to group variables or observations into strongly inter-related subgroups. In epidemiology, it may be used to analyze a closely grouped series of events or cases of disease or other health-related phenomenon with well-defined distribution patterns in relation to time or place or both.
The phenomenon by which dissociated cells intermixed in vitro tend to group themselves with cells of their own type.
Colloids with a gaseous dispersing phase and either liquid (fog) or solid (smoke) dispersed phase; used in fumigation or in inhalation therapy; may contain propellant agents.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
A set of genes descended by duplication and variation from some ancestral gene. Such genes may be clustered together on the same chromosome or dispersed on different chromosomes. Examples of multigene families include those that encode the hemoglobins, immunoglobulins, histocompatibility antigens, actins, tubulins, keratins, collagens, heat shock proteins, salivary glue proteins, chorion proteins, cuticle proteins, yolk proteins, and phaseolins, as well as histones, ribosomal RNA, and transfer RNA genes. The latter three are examples of reiterated genes, where hundreds of identical genes are present in a tandem array. (King & Stanfield, A Dictionary of Genetics, 4th ed)
The transference of pancreatic islets within an individual, between individuals of the same species, or between individuals of different species.
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
A zinc-containing enzyme which oxidizes primary and secondary alcohols or hemiacetals in the presence of NAD. In alcoholic fermentation, it catalyzes the final step of reducing an aldehyde to an alcohol in the presence of NADH and hydrogen.
A publication issued at stated, more or less regular, intervals.
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
The premier bibliographic database of the NATIONAL LIBRARY OF MEDICINE. MEDLINE® (MEDLARS Online) is the primary subset of PUBMED and can be searched on NLM's Web site in PubMed or the NLM Gateway. MEDLINE references are indexed with MEDICAL SUBJECT HEADINGS (MeSH).
Publications in any medium issued in successive parts bearing numerical or chronological designations and intended to be continued indefinitely. (ALA Glossary of Library and Information Science, 1983, p203)
The event that a FETUS is born dead or stillborn.
Suspensions of killed or attenuated microorganisms (bacteria, viruses, fungi, protozoa), antigenic proteins, synthetic constructs, or other bio-molecular derivatives, administered for the prevention, amelioration, or treatment of infectious and other diseases.
Expulsion of the product of FERTILIZATION before completing the term of GESTATION and without deliberate interference.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
Three or more consecutive spontaneous abortions.
Vaccines in which the infectious microbial nucleic acid components have been destroyed by chemical or physical treatment (e.g., formalin, beta-propiolactone, gamma radiation) without affecting the antigenicity or immunogenicity of the viral coat or bacterial outer membrane proteins.
Suspensions of attenuated or killed viruses administered for the prevention or treatment of infectious viral disease.
A gonadal stimulant and inducer of ovulation. It is used in the treatment of infertility and amenorrhea, but is thought to be less effective than CLOMIPHENE.
Four fused benzyl rings with three linear and one angular, that can be viewed as a benzyl-phenanthrenes. Compare with NAPHTHACENES which are four linear rings.
A nonmetallic, diatomic gas that is a trace element and member of the halogen family. It is used in dentistry as flouride (FLUORIDES) to prevent dental caries.
A circumscribed benign epithelial tumor projecting from the surrounding surface; more precisely, a benign epithelial neoplasm consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic cells. (Stedman, 25th ed)
A class of chemicals that contain an anthracene ring with a naphthalene ring attached to it.
1,2-Benzphenanthrenes. POLYCYCLIC COMPOUNDS obtained from coal tar.
A voluntary organization concerned with the prevention and treatment of cancer through education and research.
An operating division of the US Department of Health and Human Services. It is concerned with the overall planning, promoting, and administering of programs pertaining to health and medical research. Until 1995, it was an agency of the United States PUBLIC HEALTH SERVICE.
Component of the NATIONAL INSTITUTES OF HEALTH. It conducts and supports basic and applied research to reduce the burden of human illness and dysfunction from environmental causes by, defining how environmental exposures, genetic susceptibility, and age interact to affect an individual's health. It was established in 1969.
The science of controlling or modifying those conditions, influences, or forces surrounding man which relate to promoting, establishing, and maintaining health.
The science concerned with the detection, chemical composition, and biological action of toxic substances or poisons and the treatment and prevention of toxic manifestations.
Tests to experimentally measure the tumor-producing/cancer cell-producing potency of an agent by administering the agent (e.g., benzanthracenes) and observing the quantity of tumors or the cell transformation developed over a given period of time. The carcinogenicity value is usually measured as milligrams of agent administered per tumor developed. Though this test differs from the DNA-repair and bacterial microsome MUTAGENICITY TESTS, researchers often attempt to correlate the finding of carcinogenicity values and mutagenicity values.
Extensive collections, reputedly complete, of facts and data garnered from material of a specialized subject area and made available for analysis and application. The collection can be automated by various contemporary methods for retrieval. The concept should be differentiated from DATABASES, BIBLIOGRAPHIC which is restricted to collections of bibliographic references.
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)
Sequential operating programs and data which instruct the functioning of a digital computer.
A large collection of DNA fragments cloned (CLONING, MOLECULAR) from a given organism, tissue, organ, or cell type. It may contain complete genomic sequences (GENOMIC LIBRARY) or complementary DNA sequences, the latter being formed from messenger RNA and lacking intron sequences.
Databases containing information about PROTEINS such as AMINO ACID SEQUENCE; PROTEIN CONFORMATION; and other properties.
A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.
The study of existing genetic knowledge, and the generation of new genetic data, to understand and thus avoid DRUG TOXICITY and adverse effects from toxic substances from the environment.
A species of nematode that is widely used in biological, biochemical, and genetic studies.
Proteins from the nematode species CAENORHABDITIS ELEGANS. The proteins from this species are the subject of scientific interest in the area of multicellular organism MORPHOGENESIS.
Electropositive chemical elements characterized by ductility, malleability, luster, and conductance of heat and electricity. They can replace the hydrogen of an acid and form bases with hydroxyl radicals. (Grant & Hackh's Chemical Dictionary, 5th ed)
Rapid methods of measuring the effects of an agent in a biological or chemical assay. The assay usually involves some form of automation or a way to conduct multiple assays at the same time using sample arrays.
The functional hereditary units of HELMINTHS.
A genus of small free-living nematodes. Two species, CAENORHABDITIS ELEGANS and C. briggsae are much used in studies of genetics, development, aging, muscle chemistry, and neuroanatomy.

Effect of magnetic field exposure on anchorage-independent growth of a promoter-sensitive mouse epidermal cell line (JB6). (1/596)

The anchorage-independent growth of mouse epidermal cells (JB6) exposed to 60-Hz magnetic fields (MF) was investigated. Promotion-responsive JB6 cells were suspended in agar (10(4)cells/plate) and exposed continuously to 0.10 or 0.96 mT, 60-Hz magnetic fields for 10-14 days, with or without concurrent treatment with the tumor promoter tetradecanoylphorbol acetate (TPA). Exposures to MF were conducted in a manner such that the experimenter was blind to the treatment group of the cells. At the end of the exposure period, the anchorage-independent growth of JB6 cells on soft agar was examined by counting the number of colonies larger than 60 microm (minimum of 60 cells). The use of a combined treatment of the cells with both MF and TPA was to provide an internal positive control to estimate the success of the assay and to allow evaluation of co-promotion. Statistical analysis was performed by a randomized block design analysis of variance to examine both the effect of TPA treatment (alone and in combination with MF exposure) and the effect of intra-assay variability. Transformation frequency of JB6 cells displayed a dose-dependent response to increasing concentrations of TPA. Coexposure of cells to both TPA and 0.10 or 0.96 mT, 60-Hz MF did not result in any differences in transformation frequency for any TPA concentrations tested (0-1 ng/ml). These data indicate that exposure to a 0.10 or 0.96 mT, 60-Hz MF does not act as a promoter or co-promoter in promotion-sensitive JB6 cell anchorage-independent growth.  (+info)

Possible carcinogenic effects of X-rays in a transgenerational study with CBA mice. (2/596)

A lifetime experiment using 4279 CBA/J mice was carried out to investigate whether the pre-conceptual exposure of sperm cells to X-ray radiation or urethane would result in an increased cancer risk in the untreated progeny, and/or increased susceptibility to cancer following exposure to a promoting agent. The study consisted of four main groups, namely a control group (saline), a urethane group (1 mg/g body wt) and two X-ray radiation groups (1 Gy, 2 Gy). At 1, 3 and 9 weeks after treatment, the males of these four parental groups were mated with untreated virgin females. The offspring of each parental group was divided into two subgroups: one received s.c. urethane (0.1 mg/g body wt once) as a promoter, the other saline, at the age of 6 weeks. All animals were evaluated for the occurrence of tumours. K-ras oncogene and p53 tumour suppressor gene mutations were investigated in frozen lung tumour samples. The female offspring of male parents exposed to X-rays 1 week before their mating showed a trend towards a higher tumour incidence of the haematopoietic system than the F1 controls. In addition, a higher percentage of bronchioloalveolar adenocarcinomas in male offspring born to irradiated paternals mated 1 week after X-ray treatment points to a plausible increased sensitivity of post-meiotic germ cell stages towards transgenerational carcinogenic effects. On the other hand, no increased tumour incidence and malignancy were observed in the offspring born to irradiated paternals mated 3 and 9 weeks after X-ray treatment. Paternal urethane treatment 1, 3 and 9 weeks prior to conception did not result in significantly altered incidence or malignancy of tumours of the lung, liver and haematopoietic tissue in the offspring. K-ras mutations increased during tumour progression from bronchioloalveolar hyperplasia to adenoma. Codon 61 K-ras mutations were more frequent in lung tumours of urethane-promoted progeny from irradiated parents than from control parents. P53 mutations were absent from these lung alterations.  (+info)

Potency of dietary indole-3-carbinol as a promoter of aflatoxin B1-initiated hepatocarcinogenesis: results from a 9000 animal tumor study. (3/596)

Indole-3-carbinol (I3C), a metabolite of glucobrassicin found in cruciferous vegetables, is documented as acting as a modulator of carcinogenesis and, depending on timing and dose of administration, it may promote hepatocarcinogenesis in some animal models. In this study we demonstrate that, when given post-initiation, dietary I3C promotes aflatoxin B1 (AFB1)-induced hepatocarcinogenesis in the rainbow trout model at levels as low as 500 p.p.m. Trout embryos (approximately 9000) were initiated with 0, 25, 50, 100, 175 or 250 p.p.b. AFB1 by a 30 min immersion. Experimental diets containing 0, 250, 500, 750, 1000 or 1250 p.p.m. I3C were administered starting at 3 months and fish were sampled for liver tumors at 11-13 months. Promotion at the level of tumor incidence was statistically significant for all dietary levels, except 250 p.p.m. Relative potency for promotion markedly increased at dietary levels >750 p.p.m. We propose that more than one mechanism could be involved in promotion and that both estrogenic and Ah receptor-mediated pathways could be active. The estrogenicity of I3C, measured as its ability to induce vitellogenin (an estrogen biomarker in oviparous vertebrates) was evident at the lowest dietary level (250 p.p.m.), whereas CYPIA (a P450 isozyme induced through the Ah receptor pathway) was not induced until dietary levels of 1000 p.p.m. Therefore, at lower dietary levels, promotion by I3C in this model could be explained by estrogenic activities of I3C acid derivatives, as it is known that estrogens promote hepatocarcinogenesis in trout. Much stronger promotion was observed at high dietary I3C levels (1000 and 1250 p.p.m.), at which levels both CYP1A and vitellogenin were induced.  (+info)

Environmental factors as regulators and effectors of multistep carcinogenesis. (4/596)

This review highlights current knowledge of environmental factors in carcinogenesis and their cellular targets. The hypothesis that environmental factors influence carcinogenesis is widely supported by both epidemiological and experimental studies. The fact that only a small fraction of cancers can be attributed to germline mutations in cancer-related genes further buttresses the importance of environmental factors in carcinogenesis. Furthermore, penetrance of germline mutations may be modified by either environmental or other genetic factors. Examples of environmental factors that have been associated with increased cancer risk in the human population include chemical and physical mutagens (e.g. cigarette smoke, heterocyclic amines, asbestos and UV irradiation), infection by certain viral or bacterial pathogens, and dietary non-genotoxic constituents (e.g. macro- and micronutrients). Among molecular targets of environmental influences on carcinogenesis are somatic mutation (genetic change) and aberrant DNA methylation (epigenetic change) at the genomic level and post-translational modifications at the protein level. At both levels, changes elicited affect either the stability or the activity of key regulatory proteins, including oncoproteins and tumor suppressor proteins. Together, via multiple genetic and epigenetic lesions, environmental factors modulate important changes in the pathway of cellular carcinogenesis.  (+info)

A comparison of the effects of dietary cellulose and fermentable galacto-oligosaccharide, in a rat model of colorectal carcinogenesis: fermentable fibre confers greater protection than non-fermentable fibre in both high and low fat backgrounds. (5/596)

The objective of this experiment was to compare the effects of diets with either a non-fermentable fibre source (cellulose) or a fermentable fibre source [galacto-oligosaccharide (GOS)], combined with different levels of dietary fat, on the development of colorectal cancer. Male Wistar rats were fed AIN76-based diets with either a low or high level of cellulose, or a low or high level of GOS, for 9 months. The fat content of the diets was low, medium or high. All rats were treated with 1,2-dimethylhydrazine to induce colorectal tumours. Generally, the tumour incidence increased with increasing fat content in the diet. Despite marked faeces bulking, dietary cellulose either had no effect or an enhancing effect on the formation of colorectal tumours in general, although the development of carcinomas was decreased. GOS appeared to be highly protective against the development of colorectal tumours, as was demonstrated by an inhibitory effect on tumour incidence, multiplicity and size, regardless of the fat content of the diet. Neither fibre source influenced the bromodeoxyuridine labelling index determined in colon crypts or tumours. In animals fed high-GOS diets, the caecal content was significantly increased in weight and significantly decreased in pH. It was concluded that tumorigenesis was enhanced by increased fat content of the diet, and that the diets containing fermentable GOS conferred a greater protection against colorectal cancer than did the diets containing non-fermentable cellulose.  (+info)

Helicobacter pylori infection enhances glandular stomach carcinogenesis in Mongolian gerbils treated with chemical carcinogens. (6/596)

Helicobacter pylori (Hp) is thought to be a stomach carcinogen from epidemiological findings. To determine the effects of infection with the bacteria on experimental carcinogenesis, a study of the glandular stomach of Mongolian gerbils (MGs) was performed. Male MGs were treated with N-methyl-N'-nitro-N-nitrosoguanidine followed by inoculation with Hp or infected with Hp followed by N-methyl-N'-nitro-N-nitrosoguanidine administration. Animals were killed at week 50, and their excised stomachs underwent microbiological and histopathological examinations. In addition, a serological investigation was performed. The incidences of adenocarcinomas were significantly higher in animals treated with 60 or 300 p.p.m. N-methyl-N'-nitro-N-nitrosoguanidine for 10 weeks followed by Hp inoculation or Hp followed by 20 p.p.m. N-methyl-N'-nitro-N-nitrosoguanidine for 30 weeks than in the respective controls. Moreover, tumour-bearing animals had higher titres of anti-Hp antibodies than tumour-free animals. Of interest was the finding that a dose of 100 p.p.m. N-methyl-N'-nitro-N-nitrosoguanidine given to infected gerbils eradicated the Hp in about half the animals, with a concomitant reduction in the promoting effect. No tumours were found in animals infected with Hp without N-methyl-N'-nitro-N-nitrosoguanidine or non-treated gerbils. Hp infection enhances glandular stomach carcinogenesis in MGs treated with N-methyl-N'-nitro-N-nitrosoguanidine. Animals with high titres of anti-Hp antibodies are at greatest risk of developing neoplasms.  (+info)

Lack of effect of a 60 Hz magnetic field on biomarkers of tumor promotion in the skin of SENCAR mice. (7/596)

It has been proposed that extremely low frequency magnetic fields may enhance tumorigenesis through a co-promotional mechanism. This hypothesis has been further tested using the two-stage model of mouse skin carcinogenesis, i.e. 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced promotion of skin carcinogenesis in mice initiated by a single subcarcinogenic dose of 7,12-dimethylbenz[a]anthracene. Experimentation utilized three different doses of TPA within its dose-response range (0.85, 1.70 or 3.40 nmol) and examined the following early biomarkers of tumor promotion after 1, 2 and 5 weeks of promotion: increases in epidermal thickness and the labeling index of epidermal cells, induction of epidermal ornithine decarboxylase activity and down-regulation of epidermal protein kinase C activity. Mice exposed to a 60 Hz magnetic field having a flux density of 2 mT for 6 h/day for 5 days/week were compared with mice exposed to an ambient magnetic field. Within the sensitivity limits of the biomarker methodology and the exposure parameters employed, no consistent, statistically significant effects indicative of promotion or co-promotion by the magnetic field were demonstrated.  (+info)

Promoting effects of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone on rat glandular stomach carcinogenesis initiated with N-methyl-N'-nitro-N-nitrosoguanidine. (8/596)

The modifying effects of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX), a mutagenic by-product in chlorinated water, on the development of glandular stomach cancers were investigated in Wistar rats. A total of 120 males, 6 weeks of age, were divided into six groups. After initiation with 100 ppm N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) solution and 5% NaCl diet for 8 weeks, 30 rats each in groups 1-3 were given MX in the drinking water at concentrations of 30, 10, or 0 ppm for the following 57 weeks. Ten animals each in groups 4-6 were administered the MX without prior carcinogen exposure. There were no statistical significant differences in final body weights between the groups. The incidences and multiplicities of adenocarcinomas in the glandular stomachs were significantly higher (P < 0.05) in the initiated 30 ppm MX group than those in the MNNG/NaCl group. The incidences of atypical hyperplasias in the glandular stomachs were also significantly increased (P < 0.05 or 0.01) by the MX treatments. With their multiplicity, the effects were clearly dose dependent. Interestingly, the 30 ppm MX alone itself induced atypical hyperplasias in the pylorus, although the incidences and severity were low. Moreover, MX showed a tendency to enhance the development of intrahepatic cholangiocellular tumors and thyroid follicular cell tumors in the MNNG-treated animals. The results of the present study thus indicate that MX exerts promoting effects when given during the postinitiation phase of two-stage glandular stomach carcinogenesis in rats.  (+info)

In the liver, ethanol is predominantly metabolised by alcohol dehydrogenase (ADH) and CYP 2E1, resulting in acetaldehyde (AA) formation. AA, the extremely toxic first intermediate of ethanol metabolism, binds rapidly to cellular proteins and also possibly to DNA. These AA adducts represent neoantigens leading to the formation of specific antibodies.26 AA has mutagenic and carcinogenic properties leading to metaplasia, inhibition of DNA repair,27 sister chromatid exchanges,28 stimulation of apoptosis, and enhanced cell injury associated with hyperregeneration.29 According to the International Agency for Research on Cancer, there is sufficient evidence to identify AA as a carcinogen in animals.. Ethanol is metabolised by the successive action of ADH and aldehyde dehydrogenase (ALDH). For both ADH and ALDH, genetic polymorphisms have been described that influence the rate of conversion of ethanol to AA and of the latter to acetate.30 It has been consistently reported that ALDH2 is the most ...
A list of 13 letter words that begin with Co in the enable uncensored word list. coacervations coadaptations coagulability coalification coalitionists coastguardman coastguardmen coauthorships cobelligerent cocainization cocarboxylase cocarcinogens cochairperson cockfightings coconspirator cocounselling cocultivating cocultivation codependences codicological etc.
Looking for online definition of cocarcinogenesis in the Medical Dictionary? cocarcinogenesis explanation free. What is cocarcinogenesis? Meaning of cocarcinogenesis medical term. What does cocarcinogenesis mean?
TRPV1 is involved in the regulation of pain pathways (24). Capsaicin initially activates TRPV1 and excites nociceptive neurons, leading to the perception of pain. However, prolonged and repetitive exposure to capsaicin causes TRPV1 to become insensitive to noxious stimuli, resulting in desensitization (10). Thus, capsaicin-containing drugs have been developed to treat neuropathic pain through topical administration. Accumulating evidence suggests that repeated or high-dose treatments of capsaicin could cause apoptosis of TRPV1-expressing cells, primarily through the elevation of intracellular calcium ion levels (25), indicating that TRPV1-unresponsive or deficient states might be clinically important with exposure to capsaicin for a prolonged period. Because capsaicin-induced initial activation of TRPV1 is inevitably followed by desensitization, the possibility that capsaicin affects intracellular signals independently of TRPV1 cannot be excluded (26). TRPV1 expression was reportedly reduced in ...
Differential gene expression during multistage carcinogenesis.: The use of the mouse skin multistage model of carcinogenesis has aided our understanding of crit
TY - JOUR. T1 - Reactive oxygen species (ROS) in multistage carcinogenesis. AU - Panayiotidis, Mihalis I. PY - 2008/7/18. Y1 - 2008/7/18. U2 - 10.1016/j.canlet.2008.02.027. DO - 10.1016/j.canlet.2008.02.027. M3 - Editorial. C2 - 18359554. VL - 266. SP - 3. EP - 5. JO - Cancer Letters. JF - Cancer Letters. SN - 0304-3835. IS - 1. ER - ...
Bienvenido a Galeria de Fotos CochesRc. Aran s Fotos. Fotos: mg 6715 cochesrc promotion, mg 6716 cochesrc promotion, mg 6717 cochesrc promotion, mg 6718 cochesrc promotion, mg 6719 cochesrc promotion, mg 6720 cochesrc promotion, mg 6724 cochesrc promotion, mg 6726 cochesrc promotion, mg 6728 cochesrc promotion, mg 6729 cochesrc promotion, mg 67...
梅子濃縮顆粒 UMEKEN 梅子濃縮顆粒,使用獨特的濃縮方法,熬煮青梅三天三夜, 50倍濃縮製成的高品質的梅子濃縮顆粒使用方便,新産品梅子濃縮顆粒容量大小適合全家人一起服用。 Umeken (New) 梅子濃縮顆粒的功效... ...
china-lipo-laser-machine,good-quality-lipo-laser,cold-laser-machine-for-sale,china-cold-laser-supplier,i-lipo-machine,i-lipo-laser-for promotion,professional-i-lipo-laser-machine
In the liver, ethanol is predominantly metabolised by alcohol dehydrogenase (ADH) and CYP 2E1, resulting in acetaldehyde (AA) formation. AA, the extremely toxic first intermediate of ethanol metabolism, binds rapidly to cellular proteins and also possibly to DNA. These AA adducts represent neoantigens leading to the formation of specific antibodies.26 AA has mutagenic and carcinogenic properties leading to metaplasia, inhibition of DNA repair,27 sister chromatid exchanges,28 stimulation of apoptosis, and enhanced cell injury associated with hyperregeneration.29 According to the International Agency for Research on Cancer, there is sufficient evidence to identify AA as a carcinogen in animals.. Ethanol is metabolised by the successive action of ADH and aldehyde dehydrogenase (ALDH). For both ADH and ALDH, genetic polymorphisms have been described that influence the rate of conversion of ethanol to AA and of the latter to acetate.30 It has been consistently reported that ALDH2 is the most ...
Model averaging has attracted increasing attention in recent years for the analysis of high-dimensional data. By weighting several competing statistical models suitably, model averaging attempts to achieve stable and improved prediction. In this paper, we develop a two-stage model averaging procedure to enhance accuracy and stability in prediction for high-dimensional linear regression. First we employ a high-dimensional variable selection method such as LASSO to screen redundant predictors and construct a class of candidate models, then we apply the jackknife cross-validation to optimize model weights for averaging. In simulation studies, the proposed technique outperforms commonly used alternative methods under high-dimensional regression setting, in terms of minimizing the mean of the squared prediction error. We apply the proposed method to a riboflavin data, the result show that such method is quite efficient in forecasting the riboflavin production rate, when there are thousands of genes and only
Mi 12-14 in V2-213; Fr 12-14 in U2-113; Do 10-12, einmalig in V3-201; Do 12-14, einmalig in T2-228; Do 10-12, einmalig in V3-201; Do 12-14, einmalig in T2-228; Do 12-14, einmalig in T2-228; Do 12-14, einmalig in T2-228; Do 10-12, einmalig in V2-105/115; Do 12-14, einmalig in T2-228; Do 12-14, einmalig in T2-228 ...
The role of the lung in stomach carcinogenesis is discussed, and a revision of the Meyer hypothesis of stomach carcinogenesis is presented. According to the Meyer hypothesis, the risk for lung or stomach cancer in susceptible individuals is related to pulmonary clearance of carcinogenic particles as follows: the risk of lung cancer is decreased when particle retention in the lungs is increased and
ATSDR (Agency for Toxic Substances and Disease Registry). 1990. Toxicological Profile for Benzo(a)pyrene. Prepared by ICF-Clement, under Contract No. 68-02-4235. ATSDR/TP-88-05. Bingham, E. and H.L. Falk. 1969. Environmental carcinogens. The modifying effect of cocarcinogens on the threshold response. Arch. Environ. Health 19: 779-783. Blanton, R.H., M. Lyte, M.J. Myers, and P.H. Bick. 1986. Immunomodulation by polyaromatic hydrocarbons in mice and murine cells. Cancer Res. 46: 2735-2739. Brune, H., R.P. Deutsch-Wenzel, M. Habs, et al. 1981. Investigation of the tumorigenic response to benzo(a)pyrene in aqueous caffeine solution applied orally to Sprague-Dawley rats. J. Cancer Res. Clin. Oncol. 102: 153-157. Budavari, S., M.J. ONeil and A. Smith. 1989. The Merck Index. Merck & Co., Rahway, NJ, p. 172. Busby, W.F., Jr., M.E. Goldman, P.M. Newberne and G.N. Wogan. 1984. Tumorigenicity of fluoranthene in a newborn mouse lung adenoma bioassay. Carcinogenesis 5: 1311-1316. Chang, L.H. 1943. The ...
Sodium Saccharin Manufacturers, Factory, Suppliers From China, Our concept is to help presenting the confidence of each buyers with the offering of our most sincere service, and the right product.
In addition, his research will make it possible to accurately measure how much exposure people have had to the cancer-causing chemicals in tobacco, said Dr. Curtis Harris, chief of the Laboratory of Human Carcinogenesis at the National Institutes of Health. A key aspect of the work was figuring out how to detect and measure a metabolite, or breakdown product, of NNK. Finding it in the urine means that NNK got into the lungs, into the bloodstream, was metabolized by enzymes and just a portion of it was excreted in the urine, Harris said ...
The power to change is within you. When you think or feel something negative DO THE OPPOSITE. Take the challenge, begin the change today!!!
Muhammed K z lg l, Mustafa Cal kan, Bekir U an, Selvihan Beysel, M mtaz Tak r, Erkam Sencar, Davut Sak z, Erman akal, Mustafa ...
Chinese Manufacturer 4-6 Mesh, 5-8 Mesh, 20-40 Mesh Sodium Saccharin, Find details about China Sodium Saccharin, Food Grade Sodium Saccharin from Chinese Manufacturer 4-6 Mesh, 5-8 Mesh, 20-40 Mesh Sodium Saccharin - Zibo Qingxin Chemicals Co., Ltd.
Sodium Saccharin - Browse fuzing.com to find sodium saccharin sellers, suppliers, wholesalers, companies, manufacturers, exporters, factories.
A two-stage model for achieving X-ray amplifying action on photoionized K-transitions pumped by the soft X-ray broadband flux from laser-produced plasma is treated. A simple pumping criterion is considered by the analysis of the positive gain-length product for the two-stage model of innershell transitions (0) → (3) and (2) → (1). The incident photon flux integrated over the effective lifetime T21 of an innershell transition (2) → (1) is related to the photoionization coefficient μ03(ph), stimulated emission cross section σ21(stim), and the effective gainlength L(eff) ≃ 0.63/μ03(abs), where μ03(abs) is the absorption coefficient of a pump soft X-ray radiation. Numerical estimates for the feasibility of K-shell X-ray amplification are given for C, F, Na, Ti, and Sn. For the example of an exponential X-ray carrier pulse (XCP) propagating through a resonant medium, an amplifying effect depending on the ratio of the input pulse temporal bandwidth τband to the effective lifetime T21 is ...
Tea, instant, sweetened with sodium saccharin, lemon-flavored, prepared - nutrtion information: calories, carbohydrates, protein, fat and other nutritional food data
Jams and preserves, dietetic (with sodium saccharin), any flavor Nutrition - BellaOnline Nutrition Database - BellaOnline is committed to helping our visitors become healthy and happy. Our BellaOnline Nutrition Database will help you choose the healthiest foods for your chosen lifestyle.
We use cookies to enhance your experience on our website. By continuing to use our website, you are agreeing to our use of cookies. You can change your cookie settings at any time.Find out more ...
Lining up plans in Benalmádena? Whether youre a local, new in town, or just passing through, youll be sure to find something on Eventbrite that piques your interest.
Presents information describing investigations of molecular aspects of the mechanisms involved in chemical, physical, and viral (biological) carcinogenesis
balık Şeklinde taşlı usb bellek | Baskent Promotion, promotion products, usb stick imports, printed products, vip promotion products
Phorbol ester tumor promoters and the anti-tumor-promoter dexamethasone share a molecular target: modulation of the transcription factor AP-1 by novel type of ...
China Food Additive Sodium Saccharin 99%, Find details about China Sodium Saccharin, Saccharin from Food Additive Sodium Saccharin 99% - Xinle City Hongyuan Carbon Black Sales Center
The discovery that phorbol ester tumor promoters inhibit metabolic cooperation (MC) between several cell types in vitro fostered the idea that the effect might be associated with tumor promoters in general. The authors are testing the hypothesis by assessing the effects of tumor promoters, selected metabolites, and other chemicals on MC between cocultivated mutant (HGPRT-) and wild-type (HGPRT+) V79 cells in reconstructed selection experiments. Correlation studies show that many structurally-diverse promoters inhibit MC in a dose-related fashion. More recent studies show that ethanol, a surface-active solvent with cocarcinogenic activity in humans, inhibits MC at high concentrations (10-20 mg/ml). Phenol, a weak promoter of tumors on mouse skin, has no effect on MC at concentrations ranging from 50 to 400 micrograms/ml. Five metabolites of phenol block MC, but at least two others appear to be inactive as complete promoters for mouse skin ...
Thyroid cancer has the fastest growing incidence in the US. However, the underlying causes are still under debate. We analyzed thyroid cancer incidence in the SEER-9 registry from 1973-2010 using multistage carcinogenesis and age-period-cohort models. Multistage models were used to investigate differences in initiation, promotion and malignant conversion rates of thyroid tumors by sex, race, stage, and histology. Models were adjusted for period and cohort trends to investigate the contributions of each factor, and determine whether birth- or diagnosis-year better correlate with observed incidence patterns. Significant increases in thyroid cancer incidence by period or calendar-year were found for all sex, race, stage and histology combinations, particularly for localized cases (a 3- and 4-fold increase from 1973-2010 for females and males, respectively). Multistage analyses suggest that the 3-fold higher incidence in women could be explained by 1.5-fold higher initiation and promotion rates. Analyses by
The SENCAR stock of mice has proved to be a useful model in dissecting out the multistage nature as well as the critical mechanisms involved in skin tumorigenesis. This outbred stock was selectively bred to be susceptible to initiation with 7,12-dimethylbenz[a]anthracene (DMBA) and promotion with 12-O-tetradecanoylphorbol-13-acetate (TPA). In order to obtain mice more suitable for genetic analyses of tumor susceptibility and tissue transplantation studies, several inbred lines of mice were derived from the SENCAR stock. One of these lines, the SSIN mice, has a higher susceptibility to tumor promotion compared to the SENCAR stock but is very resistant to tumor progression. On the other hand, the SENCAR B/Pt mice, derived also from the outbred stock, not only have a tumor promotion susceptibility almost identical to the SSIN mice, but they also have a high susceptibility to tumor progression. In order to understand the nature of the phenotypic differences between these two inbred lines we have ...
The purpose of this study is to evaluate the forecasting ability of GARCH-type models in estimating the Value-at-Risk (VaR) by introducing a new four-parameter distribution, called Exponentiated Odd Log-Logistic Normal distribution. The statistical properties of new heavy-tailed distribution are investigated and a simulation study is performed to assess the maximum likelihood estimations of introduced distribution. Then, the VaR is forecasted by using mean and volatility forecasts and quantile estimation of introduced distribution. Daily VaR forecasting ability of proposed two-stage model is compared with the GARCH models specified under heavy-tailed distributions by means of two backtesting methods. Empirical findings show that proposed two-stage model outperforms to well-known distributions such as normal, Students-t, generalized error, and skewed generalized error distributions at high quantiles. ...
There is hardly any other field in chemical carcinogenesis in which such good agreement between experimental and clinical results has been reached as in carcinogenesis induced by antineoplastic...
s-link ip-g19 10000mah 1 usb port 2 in 1 kablo powerbank beyaz taşınabilir pil Şarj cihazı | Baskent Promotion, promotion products, usb stick imports, printed products, vip promotion products
More than half a century has elapsed since the carcinogenic effects of radiation were first recorded. Study of such effects has since received continuing impetus from the early and expanding uses of...
Although in individual experiments genes were identified where the expression appeared to be affected by exposure, none of these genes were regulated in the same manner in subsequent repetition experiments. The lack of a reproducible effect of the magnetic field on the expression of any genes adds further weight to the evidence that 50 Hz magnetic fields are not capable of interacting with biological systems and thus do not represent an endothelial stress factor. ...
This course introduces some methods commonly used in program evaluation and real-world effectiveness studies, including two-stage modeling, interrupted time-series, regression discontinuity, and propensity score matching. These methods help address questions such as: Which medicine is more effective in the real world? Did an advertising program have an impact on sales? More generally, are the changes in outcomes causally related to the program being run?
This course introduces some methods commonly used in program evaluation and real-world effectiveness studies, including two-stage modeling, interrupted time-series, regression discontinuity, and propensity score matching. These methods help address questions such as: Which medicine is more effective in the real world? Did an advertising program have an impact on sales? More generally, are the changes in outcomes causally related to the program being run?
calculation: average exposure: arithmetic mean of all readings taken in the two or three rooms in which the participant spent one hour or more per day on average. Time-integrated exposure: multiplying the average estimated hours spent in each room by the mean of the readings taken in the room, and summing across the rooms in which the participant spent one or more hours per day on ...
A selected ion monitoring method for the estimation of an anti-allergy compound isamaxole (N-butyl-N-(4-methyloxazol-2-yl)-2-methylpropanamide, LRCL 3950) in plasma has been developed. The method uses a stable analogue containing nine deuterium atoms
Bladder cancer represents a major public health burden. The cost per bladder cancer patient from diagnosis to death is the highest among all cancers ($96,000 to...
There are 49 calories in 4 tablespoons of Tea (Lemon Flavored, Instant Powder, Decaffeinated, with Sodium Saccharin). Get full nutrition facts and other common serving sizes of Tea (Lemon Flavored, Instant Powder, Decaffeinated, with Sodium Saccharin) including 2 tsps and 1 oz.
As emission standards become more stringent, many studies have been carried out to understand and reduce the emissions from diesel combustion engines, among which nitric oxide (NO) emissions and soot are known to have the trade-off relation during combustion processes. One aspect of this trade-off is manifested by the role radiation heat transfer plays on post-flame gas temperature, thus affecting NO formation. For example, a decrease in in-cylinder soot decreases radiation heat transfer causing an increase in post-flame gas temperature and partially contributing to the corresponding soot-NO relationship with an increase in NO formation.This topic has re-emerged with the increased use of biodiesel; a potential explanation for the so-called biodiesel NOx penalty is biodiesels inherently reduced in-cylinder soot. In order to assess how much radiation heat transfer may affect NO formation, this study seeks to isolate and control the soot formation of petroleum diesel through the use of barium ...
Malech, Harry L., Cytological changes during chemical carcinogenesis in mouse epithelium; the appearance of cytochalasin B-sensitive microfilaments (1972). Yale Medicine Thesis Digital Library. 2893 ...
Enhance immunity L-alanine cas 56-41-7 with white crystalline Name L-alanine CAS 56-41-7 Density 1.2±0.1 g/cm3 Boiling Point 212.9±23.0 °C at
TY - JOUR. T1 - Collaboration of RON and Epidermal Growth Factor Receptor in Human Bladder Carcinogenesis. AU - Hsu, Pei Yin. AU - Liu, Hsiao Sheng. AU - Cheng, Hong Lin. AU - Tzai, Tzong Shin. AU - Guo, How Ran. AU - Ho, Chung Liang. AU - Chow, Nan Haw. PY - 2006/11. Y1 - 2006/11. N2 - Purpose: Collaboration of heterologous receptor tyrosine kinases has emerged as an important paradigm in tumor progression. We recently proved that RON has an important role in human bladder carcinogenesis. Since epidermal growth factor receptor has been suggested to cross-talk with RON, we examined the significance of epidermal growth factor receptor in modulating RON associated tumorigenesis. Materials and Methods: The biological significance of collaboration between RON and epidermal growth factor receptor was examined in the TSGH8301, J82 and JR bladder cancer cell lines with different expression status. Immunoprecipitation and immunoblotting assays were done to investigate the interaction of RON with ...
TY - JOUR. T1 - Topical retinoic acid reduces skin papilloma formation but resistant papillomas are at high risk for malignant conversion. AU - Tennenbaum, Tamar. AU - Lowry, David. AU - Darwiche, Nadine. AU - Morgan, David L.. AU - Gartsbein, Marina. AU - Hansen, Laura. AU - De Luca, Luigi M.. AU - Hennings, Henry. AU - Yuspa, Stuart H.. PY - 1998/4/1. Y1 - 1998/4/1. N2 - Retinoic acid (RA) was topically applied to the skin of Sencar mice during the promotion phase of specific tumor induction protocols that produce papillomas at low (12-O-tetradecanoylphorbol-13-acetate promoted, TPA) or high (mezerein-promoted) risk for premalignant progression and malignant conversion. RA consistently reduced the yield of papillomas and carcinomas in both protocols, but the frequency of malignant conversion in papillomas that emerged during RA treatment was not reduced. When TPA was reapplied after cessation of RA treatment, the number of papillomas increased 2-fold, suggesting that RA had not eliminated ...
Mutations in TGF-βRII have been detected in malignant cell lines and cancers (24, 25, 26, 27, 28, 29, 31 , 31, 32, 33) , suggesting that inactivation of TGF-βRII is an important mechanism for malignant progression at late stages of carcinogenesis. Previous reports on transgenic mice expressing ΔβRII in the mammary gland and lung (47) or basal epidermal keratinocytes (45) have consistently demonstrated that loss of TGF-β responsiveness plays a late role in chemical carcinogenesis. Interestingly, we observed an accelerated benign papilloma formation in ML.ΔβRII mice at a very early stage (Fig. 1, A and B) ⇓ . More surprisingly, we observed that TPA application alone, without DMBA initiation, induced papilloma formation in ML.ΔβRII mice (Fig. 3B) ⇓ . These results suggest that blocking TGF-βRII signaling can serve as an initiating event in skin carcinogenesis. Supporting this, most of the TPA-induced papillomas in ML.ΔβRII mice did not exhibit c-rasHa mutations (Table 1) ⇓ , a ...
Definition of non-genotoxic carcinogen and genotoxic carcinogens and whether there are any thresholds for carcinogens from a regulatory perspective.
Sodium saccharin is a synthetic sweetener known to be about 300 times sweeter than sugar. It is used as a flavouring agent in the formulation of dental products, mouthwash and lipstick. It can also be used to mask the odours of other ingredients.
Table 8-1 lists definitions of terms commonly used in discussing chemical carcinogenesis. For benign neoplasms, the tissue of origin is frequently followed by the suffix oma; e.g., a benign fibrous neoplasm would be termed fibroma, and a benign glandular epithelium termed an adenoma. Malignant neoplasms from epithelial origin are called carcinomas, whereas those derived from mesenchymal origin are referred to as sarcoma. Thus, a malignant neoplasm of fibrous tissue would be a fibrosarcoma, whereas that derived from bone would be an osteosarcoma. ...
A two-stage model estimates aggregate and source-specific import demand elasticities for pork in Japan. The low income elasticity of imported pork and low income elasticity of U.S. pork reflect consumer survey results of low quality rating for imported pork compared to domestic pork, and rating for U.S. pork not higher than Canadian pork. To maintain and increase market share, the U.S. needs strategies to reverse consumer attitude by positioning U.S. pork as high quality, safe, and low cost. Fabiosa, Jacinto F.; Ukhova, Yekaterina S.
Creative-Proteomics offer cas NA JWH-073 3-HYDROXYBUTYL METABOLITE (INDOLE-D5, 98%) 100 UG/ML IN METHANOL. We are specialized in manufacturing Stabel Isotope Labeled Analytical Standard products.
Cytogenetic studies are providing clues to the growth regulatory genes involved in human carcinogenesis and to mechanisms that alter their function. Investigations of chromosome translocations in B and T cell lymphomas and in chronic myelogenous leukemia have demonstrated the effects on protooncogen …
Name: CA Name: Anthracene Molecular Structure: Anthracene,CAS 120-12-7,178.23,C14H10 Anthracene,CAS 120-12-7,178.23,C14H10 Molecular Formula:C14H10 Molecular Weight: 178.23 CAS Registry Number: 120-12-7
Carcinogenesis is a multi-stage process of accumulation of changes in the genome of cells, resulting in the appearance of asocial cells characterized by morphological, functional, biochemical atypism, autonomous growth, evasion of cells from humoral and nervous influences, says Dr. Denis Slinkin.
Salnikow K, Zhitkovich (January 2008). "Genetic and epigenetic mechanisms in metal carcinogenesis and cocarcinogenesis: nickel ...
Salnikow, K.; Zhitkovich, A. (2008). "Genetic and Epigenetic Mechanisms in Metal Carcinogenesis and Cocarcinogenesis: Nickel, ...
Liu, S. (2005). Effects of arsenic on DNA repair and cell checkpoints involvement in arsenic co-mutagenesis and co-carcinogenesis ...
... cocarcinogenesis MeSH C23.550.727.645 - neoplasm invasiveness MeSH C23.550.727.645.500 - leukemic infiltration MeSH C23.550. ...
Chemistry · 1,2-Dimethylhydrazine · Animals · Bile Acids and Salts · Carcinogens · Cecum · Cellulose · Cocarcinogenesis · ... Tissue damage and nutritional factors in experimental respiratory tract (co-)carcinogenesis article. 1983 ... Nutrition · Animals · Anticarcinogenic Agents · Azaserine · Body Weight · Carcinogens · Cell Division · Cocarcinogenesis · ... Cocarcinogenesis · Female · Flour · Hyperplasia · Male · Pancreas · Pancreatic Ducts · Pancreatic Neoplasms · Poultry · Random ...
What is cocarcinogenesis? Meaning of cocarcinogenesis medical term. What does cocarcinogenesis mean? ... Looking for online definition of cocarcinogenesis in the Medical Dictionary? cocarcinogenesis explanation free. ... cocarcinogenesis. cocarcinogenesis. [ko-kahr″sĭ-no-jen´ĕ-sis] the development, according to one theory, of cancer only in ... cocarcinogenesis. /co·car·ci·no·gen·e·sis/ (ko-kahr″sĭ-no-jen´ĕ-sis) the development, according to one theory, of cancer only ...
Borek C., Ong A., Mason H., Zaider M., Witz G., Mehlman M.A. (1987) Ozone Carcinogenesis and Co-Carcinogenesis and its ...
"Cocarcinogenesis" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Cocarcinogenesis" by people in this website by year, and ... Below are the most recent publications written about "Cocarcinogenesis" by people in Profiles. ... whether "Cocarcinogenesis" was a major or minor topic of these publications. To see the data from this visualization as text, ...
Cocarcinogenesis. Biochim. Biophys. Acta 505: 67-89.Google Scholar. *. 8.. Diamond, L., T.G. OBrien, and G. Rovera. 1979. ...
20.5 Photo Co-Carcinogenesis 418. 20.6 Future Testing Concepts, with Emphasis on Biomarkers 423 ...
We have tested an 836.55 MHz field with North American Digital Cellular (NADC) modulation in a 2-year animal bioassay that included fetal exposure. In offspring of pregnant Fischer 344 rats, we tested both spontaneous tumorigenicity and the incidence of induced central nervous system (CNS) tumors af …
Onion and garlic essential oils were previously shown to inhibit mouse skin tumor promotion, as were the enzymes, lipoxygenase, and cyclooxygenase. In the present study, the inhibition of soybean lipoxygenase (EC 1.13.11.12) by onion and garlic components and related compounds was investigated. The …
Cocarcinogenesis, immunotoxicity, endocrine disruption. 4-Hydroxynonenal malondialdehyde. Aldehydes (DNA-reactive). ...
Cocarcinogenesis. Likelihood Functions. Liver / drug effects, pathology. Liver Neoplasms, Experimental / chemically induced, ...
Cocarcinogenesis. Cookery. Diet Surveys. Disease Models, Animal. Energy Intake. Feeding Behavior. Female. Food / adverse ...
Acetaldehyde seems to be involved in ethanol-associated cocarcinogenesis. The metabolism of retinol and the generation of ... cell differentiation and cell growth and may also be involved in ethanol-associated gastrointestinal cocarcinogenesis. ...
Shamberger, R.J. & Rudolph, G. (1966). Protection against cocarcinogenesis by antioxidants. Experienta., 22, 116. Shamberger, R ...
Viruses, chemicals and co-carcinogenesis. ...Use of Kochs postulates will not help one prove or disprove a multifactorial ...
Mutation studies of NA showed interference with cellular DNA repair and possible cocarcinogenesis. Less than 5000 workers were ...
"Genetic and Epigenetic Mechanisms in Metal Carcinogenesis and Cocarcinogenesis: Nickel, Arsenic, and Chromium". Chem. Res. ...
Mechanisms of Tumor Promotion and Cocarcinogenesis by Thomas J. Slaga - 1978 - 558 pages. ... Mechanisms of tumor promotion and cocarcinogenesis by Thomas J. Slaga - 1978 - 558 pages. ...
Categories: Cocarcinogenesis Image Types: Photo, Illustrations, Video, Color, Black&White, PublicDomain, CopyrightRestricted 36 ...
Cocarcinogenesis. *Female. *Hydrocarbons, Fluorinated (toxicity) *Mice. *Neoplasms, Experimental (chemically induced) * ...
Photo-Co-Carcinogenesis of Topically Applied Retinyl Palmitate in SKH-1 Hairless Mice.. Boudreau M., Beland F., Felton R., Fu P ...
Arsenite cocarcinogenesis: an animal model derived from genetic toxicology studies. Environ Health Perspect 110(suppl 5):749- ...
ARSENIC CO-CARCINOGENESIS WITH UVR: NITROSATION AND OXIDATION OF TARGET PROTEINS Investigators. Hudson, Laurie G; Liu, Ke Jian ...
Salnikow, K.; Zhitkovich, A. Genetic and epigenetic mechanisms in metal carcinogenesis and cocarcinogenesis: Nickel, arsenic, ...
Salnikow, K., and Zhitkovich, A. (2008). Genetic and epigenetic mechanisms in metal carcinogenesis and cocarcinogenesis: nickel ...
Salnikow K, Zhitkovich (January 2008). "Genetic and epigenetic mechanisms in metal carcinogenesis and cocarcinogenesis: nickel ...
Salnikow, K. and Zhitkovich, A. Genetic and epigenetic mechanisms in metal carcinogenesis and cocarcinogenesis: nickel, arsenic ... Salnikow, K. and Zhitkovich, A. Genetic and epigenetic mechanisms in metal carcinogenesis and cocarcinogenesis: nickel, arsenic ...
... to test for cocarcinogenesis. In controls, HM and HF were exposed to concentrations of crocidolite ranging from 0.1 to 5.0 μg/ ... MM may be a new example of cocarcinogenesis between a virus (SV40) and a ubiquitous environmental carcinogen (asbestos). ...
Co-carcinogenesis: Human Papillomaviruses, Coal Tar Derivatives, and Squamous Cell Cervical Cancer. Front Microbiol. 2017;8: ...
  • Possible role of acetaldehyde in ethanol-related rectal cocarcinogenesis in the rat. (thefreedictionary.com)
  • In conclusion, because of the oncofetal phenotype of H, B, and Le(b) antigens, their reappearance in the distal colon may serve as a cytochemical marker for early recognition of epithelial changes of the colon in ethanol-related cocarcinogenesis before more overt manifestations of neoplasia. (augmentin2020.site)
  • The coke oven sample was approximately 12 times as active as the roofing tar sample as a tumor promoter in mouse skin initiated with benzo(a)pyrene (B(a)P). Cocarcinogenesis was studied in SENCAR mice by using the tumor co-initiation protocol. (epa.gov)
  • The resultant comprehensive data clearly illustrate established pathways of cancer induction involving carcinogen exposure, metabolic activation, DNA adduct formation, and consequent mutation of critical genes along with the exacerbating influences of inflammation, cocarcinogenesis, and tumor promotion. (aacrjournals.org)
  • Salnikow K, Zhitkovich A (2008) Genetic and epigenetic mechanisms in metal carcinogenesis and cocarcinogenesis: nickel, arsenic, and chromium. (springer.com)
  • Florea A, Yamoah EN, Dopp E. Intracellular Calcium Disturbances Induced by Arsenic and Its Methylated Derivatives in Relation to Genomic Damage and Apoptosis Induction. (aaem.pl)
  • The cocarcinogenesis studies using IR chrysotile asbestos and 1,2-dimethylhydrazine dihydrochloride were considered inadequate because there was no increase in intestinal neoplasia in the DMH group. (nih.gov)
  • Acetaldehyde seems to be involved in ethanol-associated cocarcinogenesis. (nih.gov)
  • The metabolism of retinol and the generation of retinoic acid is a function of class I and class IV ADH, and its inhibition by alcohol may lead to an alteration of epithelial cell differentiation and cell growth and may also be involved in ethanol-associated gastrointestinal cocarcinogenesis. (nih.gov)
  • Due to the constantly increasing hazard of styrene exposure and possible cocarcinogenesis in digestive tract with bilious acids, an experimental model of chronic exposure of stomach mucosa to styrene oxide [SO] with accompanying bilious reflux has been elaborated. (medscimonit.com)
  • Data on the cocarcinogenesis of certain Sorbitan Esters were positive, but only with high exposure levels and a high frequency of exposure, and the results lacked a dose-response. (cosmeticsinfo.org)
  • Cocarcinogenesis" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
  • This graph shows the total number of publications written about "Cocarcinogenesis" by people in this website by year, and whether "Cocarcinogenesis" was a major or minor topic of these publications. (umassmed.edu)