Coatomer protein. Medical search

A 700-kDa cytosolic protein complex consisting of seven equimolar subunits (alpha, beta, beta', gamma, delta, epsilon and zeta). COATOMER PROTEIN and ADP-RIBOSYLATION FACTOR 1 are principle components of COAT PROTEIN COMPLEX I and are involved in vesicle transport between the ENDOPLASMIC RETICULUM and the GOLGI APPARATUS.

A protein complex comprised of COATOMER PROTEIN and ADP RIBOSYLATION FACTOR 1. It is involved in transport of vesicles between the ENDOPLASMIC RETICULUM and the GOLGI APPARATUS.

A stack of flattened vesicles that functions in posttranslational processing and sorting of proteins, receiving them from the rough ENDOPLASMIC RETICULUM and directing them to secretory vesicles, LYSOSOMES, or the CELL MEMBRANE. The movement of proteins takes place by transfer vesicles that bud off from the rough endoplasmic reticulum or Golgi apparatus and fuse with the Golgi, lysosomes or cell membrane. (From Glick, Glossary of Biochemistry and Molecular Biology, 1990)

Vesicles formed when cell-membrane coated pits (COATED PITS, CELL-MEMBRANE) invaginate and pinch off. The outer surface of these vesicles are covered with a lattice-like network of coat proteins, such as CLATHRIN, coat protein complex proteins, or CAVEOLINS.

TRANSPORT VESICLES formed when cell-membrane coated pits (COATED PITS, CELL-MEMBRANE) invaginate and pinch off. The outer surface of these vesicles is covered with a lattice-like network of COP (coat protein complex) proteins, either COPI or COPII. COPI coated vesicles transport backwards from the cisternae of the GOLGI APPARATUS to the rough endoplasmic reticulum (ENDOPLASMIC RETICULUM, ROUGH), while COPII coated vesicles transport forward from the rough endoplasmic reticulum to the Golgi apparatus.

ADP-RIBOSYLATION FACTOR 1 is involved in regulating intracellular transport by modulating the interaction of coat proteins with organelle membranes in the early secretory pathway. It is a component of COAT PROTEIN COMPLEX I. This enzyme was formerly listed as EC 3.6.1.47.

MONOMERIC GTP-BINDING PROTEINS that were initially recognized as allosteric activators of the MONO(ADP-RIBOSE) TRANSFERASE of the CHOLERA TOXIN catalytic subunit. They are involved in vesicle trafficking and activation of PHOSPHOLIPASE D. This enzyme was formerly listed as EC 3.6.1.47

Coupling of coat assembly and vesicle budding to packaging of putative cargo receptors. (1/266)

COPI-coated vesicle budding from lipid bilayers whose composition resembles mammalian Golgi membranes requires coatomer, ARF, GTP, and cytoplasmic tails of putative cargo receptors (p24 family proteins) or membrane cargo proteins (containing the KKXX retrieval signal) emanating from the bilayer surface. Liposome-derived COPI-coated vesicles are similar to their native counterparts with respect to diameter, buoyant density, morphology, and the requirement for an elevated temperature for budding. These results suggest that a bivalent interaction of coatomer with membrane-bound ARF[GTP] and with the cytoplasmic tails of cargo or putative cargo receptors is the molecular basis of COPI coat assembly and provide a simple mechanism to couple uptake of cargo to transport vesicle formation. (+info)

Structural and functional analysis of the ARF1-ARFGAP complex reveals a role for coatomer in GTP hydrolysis. (2/266)

The crystal structure of the complex of ARF1 GTPase bound to GDP and the catalytic domain of ARF GTPase-activating protein (ARFGAP) has been determined at 1.95 A resolution. The ARFGAP molecule binds to switch 2 and helix alpha3 to orient ARF1 residues for catalysis, but it supplies neither arginine nor other amino acid side chains to the GTPase active site. In the complex, the effector-binding region appears to be unobstructed, suggesting that ARFGAP could stimulate GTP hydrolysis while ARF1 maintains an interaction with its effector, the coatomer complex of COPI-coated vesicles. Biochemical experiments show that coatomer directly participates in the GTPase reaction, accelerating GTP hydrolysis a further 1000-fold in an ARFGAP-dependent manner. Thus, a tripartite complex controls the GTP hydrolysis reaction triggering disassembly of COPI vesicle coats. (+info)

Clathrin and two components of the COPII complex, Sec23p and Sec24p, could be involved in endocytosis of the Saccharomyces cerevisiae maltose transporter. (3/266)

The Saccharomyces cerevisiae maltose transporter is a 12-transmembrane segment protein that under certain physiological conditions is degraded in the vacuole after internalization by endocytosis. Previous studies showed that endocytosis of this protein is dependent on the actin network, is independent of microtubules, and requires the binding of ubiquitin. In this work, we attempted to determine which coat proteins are involved in this endocytosis. Using mutants defective in the heavy chain of clathrin and in several subunits of the COPI and the COPII complexes, we found that clathrin, as well as two cytosolic subunits of COPII, Sec23p and Sec24p, could be involved in internalization of the yeast maltose transporter. The results also indicate that endocytosis of the maltose transporter and of the alpha-factor receptor could have different requirements. (+info)

Inhibition of secretion by 1,3-Cyclohexanebis(methylamine), a dibasic compound that interferes with coatomer function. (4/266)

We noted previously that certain aminoglycoside antibiotics inhibit the binding of coatomer to Golgi membranes in vitro. The inhibition is mediated in part by two primary amino groups present at the 1 and 3 positions of the 2-deoxystreptamine moiety of the antibiotics. These two amines appear to mimic the epsilon-amino groups present in the two lysine residues of the KKXX motif that is known to bind coatomer. Here we report the effects of 1, 3-cyclohexanebis(methylamine) (CBM) on secretion in vivo, a compound chosen for study because it contains primary amino groups that resemble those in 2-deoxystreptamine and it should penetrate lipid bilayers more readily than antibiotics. CBM inhibited coatomer binding to Golgi membranes in vitro and in vivo and inhibited secretion by intact cells. Despite depressed binding of coatomer in vivo, the Golgi complex retained its characteristic perinuclear location in the presence of CBM and did not fuse with the endoplasmic reticulum (ER). Transport from the ER to the Golgi was also not blocked by CBM. These data suggest that a full complement of coat protein I (COPI) on membranes is not critical for maintenance of Golgi integrity or for traffic from the ER to the Golgi but is necessary for transport through the Golgi to the plasma membrane. (+info)

Nef-induced CD4 degradation: a diacidic-based motif in Nef functions as a lysosomal targeting signal through the binding of beta-COP in endosomes. (5/266)

The Nef protein of primate lentiviruses downregulates the cell surface expression of CD4 through a two-step process. First, Nef connects the cytoplasmic tail of CD4 with adaptor protein complexes (AP), thereby inducing the formation of CD4-specific clathrin-coated pits that rapidly endocytose the viral receptor. Second, Nef targets internalized CD4 molecules for degradation. Here we show that Nef accomplishes this second task by acting as a connector between CD4 and the beta subunit of COPI coatomers in endosomes. A sequence encompassing a critical acidic dipeptide, located nearby but distinct from the AP-binding determinant of HIV-1 Nef, is responsible for beta-COP recruitment and for routing to lysosomes. A novel class of endosomal sorting motif, based on acidic residues, is thus revealed, and beta-COP is identified as its downstream partner. (+info)

p24 and p23, the major transmembrane proteins of COPI-coated transport vesicles, form hetero-oligomeric complexes and cycle between the organelles of the early secretory pathway. (6/266)

COPI-coated vesicles that bud off the Golgi complex contain two major transmembrane proteins, p23 and p24. We have localized the protein at the Golgi complex and at COPI-coated vesicles. Transport from the intermediate compartment (IC) to the Golgi can be blocked at 15 degrees C, and under these conditions p24 accumulates in peripheral punctated structures identified as IC. Release from the temperature block leads to a redistribution of p24 to the Golgi, showing that p24, similar to p23, cycles between the IC and Golgi complex. Immunoprecipitations of p24 from cell lysates and from detergent-solubilized Golgi membranes and COPI-coated vesicles show that p24 and p23 interact with each other to form a complex. Transient transfection of p23 in HeLa cells shows that p23 and p24 colocalize in structures induced by the overexpression of p23. Taken together p24 interacts with p23 and constitutively cycles between the organelles of the early secretory pathway. (+info)

Osmotically induced cell volume changes alter anterograde and retrograde transport, Golgi structure, and COPI dissociation. (7/266)

Physiological conditions that impinge on constitutive traffic and affect organelle structure are not known. We report that osmotically induced cell volume changes, which are known to occur under a variety of conditions, rapidly inhibited endoplasmic reticulum (ER)-to-Golgi transport in mammalian cells. Both ER export and ER Golgi intermediate compartment (ERGIC)-to-Golgi trafficking steps were blocked, but retrograde transport was active, and it mediated ERGIC and Golgi collapse into the ER. Extensive tubulation and relatively rapid Golgi resident redistribution were observed under hypo-osmotic conditions, whereas a slower redistribution of the same markers, without apparent tubulation, was observed under hyperosmotic conditions. The osmotic stress response correlated with the perturbation of COPI function, because both hypo- and hyperosmotic conditions slowed brefeldin A-induced dissociation of betaCOP from Golgi membranes. Remarkably, Golgi residents reemerged after several hours of sustained incubation in hypotonic or hypertonic medium. Reemergence was independent of new protein synthesis but required PKC, an activity known to mediate cell volume recovery. Taken together these results indicate the existence of a coupling between cell volume and constitutive traffic that impacts organelle structure through independent effects on anterograde and retrograde flow and that involves, in part, modulation of COPI function. (+info)

GTP-dependent binding of ADP-ribosylation factor to coatomer in close proximity to the binding site for dilysine retrieval motifs and p23. (8/266)

A site-directed photocross-linking approach was employed to determine components that act downstream of ADP-ribosylation factor (ARF). To this end, a photolabile phenylalanine analog was incorporated at various positions of the putative effector region of the ARF molecule. Depending on the position of incorporation, we find specific and GTP-dependent interactions of ARF with two subunits of the coatomer complex, beta-COP and gamma-COP, as well as an interaction with a cytosolic protein (approximately 185 kDa). In addition, we observe homodimer formation of ARF molecules at the Golgi membrane. These data suggest that the binding site of ARF to coatomer is at the interface of its beta- and gamma-subunits, and this is in close proximity to the second site of interaction of coatomer with the Golgi membrane, the binding site within gamma-COP for cytosolic dibasic/diphenylalanine motifs. (+info)

The product of this gene is an epsilon subunit of coatomer protein complex. Coatomer is a cytosolic protein complex that binds ... "Entrez Gene: COPE coatomer protein complex, subunit epsilon". Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, ... Orcl L, Palmer DJ, Amherdt M, Rothman JE (1993). "Coated vesicle assembly in the Golgi requires only coatomer and ARF proteins ... Coatomer subunit epsilon is a protein that in humans is encoded by the COPE gene. ...

https://en.wikipedia.org/wiki/COPE_(gene)

Coatomer subunit gamma is a protein that in humans is encoded by the COPG gene. It is one of seven proteins in the COPI ... "Entrez Gene: COPG coatomer protein complex, subunit gamma". Bermak, Jason C; Li Ming; Bullock Clayton; Weingarten Paul; Zhou ... 2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi: ... "Architecture of coatomer: molecular characterization of delta-COP and protein interactions within the complex" (PDF). J. Cell ...

https://en.wikipedia.org/wiki/COPG

Coatomer subunit alpha is a protein that in humans is encoded by the COPA gene. In eukaryotic cells, protein transport between ... "Entrez Gene: COPA coatomer protein complex, subunit alpha". Gerich B, Orci L, Tschochner H, Lottspeich F, Ravazzola M, Amherdt ... 1997). "Association of coatomer proteins with the beta-receptor for platelet-derived growth factor". Biochem. Biophys. Res. ... 1996). "Architecture of coatomer: molecular characterization of delta-COP and protein interactions within the complex". J. Cell ...

https://en.wikipedia.org/wiki/COPA_(gene)

Coatomer subunit gamma-2 is a protein that in humans is encoded by the COPG2 gene. COPG2 has been shown to interact with ... "Entrez Gene: COPG2 coatomer protein complex, subunit gamma 2". Bermak JC, Li M, Bullock C, Weingarten P, Zhou QY (Feb 2002). " ... Waters MG, Serafini T, Rothman JE (1991). "'Coatomer': a cytosolic protein complex containing subunits of non-clathrin-coated ... "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/ ...

https://en.wikipedia.org/wiki/COPG2

Coatomer subunit zeta-1 is a protein that in humans is encoded by the COPZ1 gene. COPZ1 has been shown to interact with COPG. ... "Entrez Gene: COPZ1 coatomer protein complex, subunit zeta 1". Futatsumori M, Kasai K, Takatsu H, Shin HW, Nakayama K (November ... "Architecture of coatomer: molecular characterization of delta-COP and protein interactions within the complex" (PDF). J. Cell ... Overview of all the structural information available in the PDB for UniProt: P61923 (Human Coatomer subunit zeta-1) at the PDBe ...

https://en.wikipedia.org/wiki/COPZ1

"The coatomer protein beta'-COP, a selective binding protein (RACK) for protein kinase Cepsilon". J. Biol. Chem. 272 (46): 29200 ... Coatomer subunit beta is a protein that is encoded by the COPB2 gene in humans. The Golgi coatomer complex (see MIM 601924) ... "Entrez Gene: COPB2 coatomer protein complex, subunit beta 2 (beta prime)". Eugster A, Frigerio G, Dale M, Duden R (August 2000 ... "Assignment of the cellular retinol-binding protein 1 gene (RBP1) and of the coatomer beta subunit gene (COPB2) to human ...

https://en.wikipedia.org/wiki/COPB2

... is a coatomer, a protein complex that coats vesicles transporting proteins from the cis end of the Golgi complex back to ... 1994). "Coatomer is essential for retrieval of dilysine-tagged proteins to the endoplasmic reticulum". Cell. 79 (7): 1199-207. ... Luminal proteins: Proteins found in the lumen of the Golgi complex that need to be transported to the lumen of the ER contain ... 1996). "A major transmembrane protein of Golgi-derived COPI-coated vesicles involved in coatomer binding". J Cell Biol. 135 (5 ...

https://en.wikipedia.org/wiki/COPI

Coatomer subunit beta is a protein that in humans is encoded by the COPB1 gene. COPI coatomer, a protein complex GRCh38: ... 1997). "Association of coatomer proteins with the beta-receptor for platelet-derived growth factor". Biochem. Biophys. Res. ... Orcl L, Palmer DJ, Amherdt M, Rothman JE (1993). "Coated vesicle assembly in the Golgi requires only coatomer and ARF proteins ... Pavel J, Harter C, Wieland FT (1998). "Reversible dissociation of coatomer: Functional characterization of a β/δ-coat protein ...

https://en.wikipedia.org/wiki/COPB1

Though PCTV does not require COPII coatomer proteins for budding from the ER, association with the coatomer is necessary for ... Without the fully functional sar1B protein, the COPll coatomer proteins engulf pre-chylomicrons exiting the ER but are unable ... Sar1B is a GTPase and one of the five proteins of the COPll coatomer. A mutation in the sar1B gene and subsequently the sar1B ... Before the PCTV leaves the ER, it is incorporated into a COPII coatomer of five proteins. The PCTV undergoes a similar ...

https://en.wikipedia.org/wiki/Chylomicron_retention_disease

Orcl L, Palmer DJ, Amherdt M, Rothman JE (1993). "Coated vesicle assembly in the Golgi requires only coatomer and ARF proteins ... 2000). "A New Paxillin-binding Protein, PAG3/Papα/KIAA0400, Bearing an ADP-Ribosylation Factor GTPase-activating Protein ... 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. Bibcode: ... The gene products include 6 ARF proteins and 11 ARF-like proteins and constitute 1 family of the RAS superfamily. The ARF ...

https://en.wikipedia.org/wiki/ARF5

Orcl L, Palmer DJ, Amherdt M, Rothman JE (1993). "Coated vesicle assembly in the Golgi requires only coatomer and ARF proteins ... The gene products include 5 ARF proteins and 11 ARF-like proteins and constitute 1 family of the RAS superfamily. The ARF ... ADP-ribosylation factor 4 is a protein that in humans is encoded by the ARF4 gene. ADP-ribosylation factor 4 (ARF4) is a member ... Shin OH, Ross AH, Mihai I, Exton JH (1999). "Identification of arfophilin, a target protein for GTP-bound class II ADP- ...

https://en.wikipedia.org/wiki/ARF4

Orcl L, Palmer DJ, Amherdt M, Rothman JE (1993). "Coated vesicle assembly in the Golgi requires only coatomer and ARF proteins ... Boman AL, Kuai J, Zhu X, Chen J, Kuriyama R, Kahn RA (1999). "Arf proteins bind to mitotic kinesin-like protein 1 (MKLP1) in a ... Boman AL, Kuai J, Zhu X, Chen J, Kuriyama R, Kahn RA (October 1999). "Arf proteins bind to mitotic kinesin-like protein 1 ( ... The gene products include 6 ARF proteins and 11 ARF-like proteins and constitute 1 family of the RAS superfamily. The ARF ...

https://en.wikipedia.org/wiki/ARF3

These vesicles have specific coat proteins (such as clathrin or coatomer) that are important for cargo selection and direction ... AP (adaptor protein) complexes are found in coated vesicles and clathrin-coated pits. AP complexes connect cargo proteins and ... Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to ... Touz MC, Kulakova L, Nash TE (July 2004). "Adaptor protein complex 1 mediates the transport of lysosomal proteins from a Golgi- ...

https://en.wikipedia.org/wiki/Beta2-adaptin_C-terminal_domain

Orcl L, Palmer DJ, Amherdt M, Rothman JE (1993). "Coated vesicle assembly in the Golgi requires only coatomer and ARF proteins ... ARF6+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH) Human ARF6 genome location and ARF6 ... D'Souza-Schorey C, Boshans RL, McDonough M, Stahl PD, Van Aelst L (1997). "A role for POR1, a Rac1-interacting protein, in ARF6 ... ADP-ribosylation factor 6 (ARF6) is a member of the ADP ribosylation factor family of GTP-binding proteins. ARF6 has a variety ...

https://en.wikipedia.org/wiki/ARF6

Adaptins are distantly related to the other main type of vesicular transport proteins, the coatomer subunits, sharing between ... Protein pages needing a picture, Peripheral membrane proteins, Protein families). ... Adaptor protein (AP) complexes are found in coated vesicles and clathrin-coated pits. AP complexes connect cargo proteins and ... Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to ...

https://en.wikipedia.org/wiki/Clathrin_adaptor_protein

Components of COPI (cop one) a coatomer, and TSET (T-set) a membrane trafficking complex have similar heterotetramers of the AP ... In the AP complexes, there are two large proteins (∼100 kD) and two smaller proteins. One of the large proteins is termed β ( ... Protein complexes, Protein families, Molecular evolution, Vesicular transport proteins). ... PTBs are protein domains that include NUMB, DAB1 and DAB2. Epsin and AP180 in the ANTH domain are other adaptor proteins that ...

https://en.wikipedia.org/wiki/Vesicular_transport_adaptor_protein

They are also common in membrane coat proteins known as coatomers, such as clathrin, and in regulatory proteins that form ... The protein-protein interaction capacity of alpha solenoid proteins also makes them well suited to function as regulatory ... extended protein-protein interaction surfaces or to form deep concave areas for binding globular proteins. Because they are ... "When protein folding is simplified to protein coiling: the continuum of solenoid protein structures". Trends in Biochemical ...

https://en.wikipedia.org/wiki/Alpha_solenoid

... a human gene that encodes the protein coatomer subunit epsilon COPE (film), a 2007 psychological thriller/horror independent ...

https://en.wikipedia.org/wiki/COPE

... a human gene that encodes the coatomer subunit alpha protein Controlling Profitability Analysis, Profitability Analysis (SAP) ...

https://en.wikipedia.org/wiki/Copa

1999). "Assignment of the cellular retinol-binding protein 1 gene (RBP1) and of the coatomer beta subunit gene (COPB2) to human ... Retinol binding protein 1, cellular, also known as RBP1, is a protein that in humans is encoded by the RBP1 gene. RBP1 is the ... "The transfer of retinol from serum retinol-binding protein to cellular retinol-binding protein is mediated by a membrane ... Alteration of relative protein amounts is linked to the state of differentiation". Biochem. J. 287. ( Pt 2) (2): 383-9. doi: ...

https://en.wikipedia.org/wiki/RBP1

The coatomer protein complex is made up of seven nonidentical protein subunits. These seven nonidentical protein subunits are ... The coatomer is a protein complex that coats membrane-bound transport vesicles. Two types of coatomers are known: COPI ( ... Coatomer+Protein at the US National Library of Medicine Medical Subject Headings (MeSH) Boehm, Markus; Bonifacino, Juan S. ( ... COP II is a coatomer that coats the vesicles transporting proteins from the ER to the golgi complex. This pathway is referred ...

https://en.wikipedia.org/wiki/Coatomer

The coatomer subunit delta (delta-COP) is a cytosolic protein complex that binds to motifs and associates with vesicles ... Role of Mammalian Vacuolar Protein-sorting Proteins in Endocytic Trafficking of a Non-ubiquitinated G Protein-coupled Receptor ... There is no evidence of post-translational modifications of the TMEM267 protein found in tissues. According to protein sequence ... The protein was identified as a member of a large group of proteins that comprise a filter in mammalian cells which allow ...

https://en.wikipedia.org/wiki/TMEM267

2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. ... Scyl1 localizes to the cis-Golgi and ER-Golgi Intermediate Compartment (ERGIC). Scyl1 binds to Coatomer I (COPI) and ... This gene encodes a transcriptional regulator belonging to the SCY1-like family of kinase-like proteins. The protein has a ... The FL protein contains HEAT repeats and a C-terminal coiled coil domain that also contains multiple dibasic motifs, and ends ...

https://en.wikipedia.org/wiki/SCYL1

... is a human protein ithat is encoded by gene which is locatedd on chromosome 11. Also known as ARCN1, it plays a role in ... It is part of the COPI coatomer complex. Xu X, Kedlaya R, Higuchi H, et al. (2010). "Mutation in archain 1, a subunit of COPI ... Protein pages needing a picture, Genes on human chromosome 11, Accuracy disputes from September 2020, All accuracy disputes, ... Peripheral membrane proteins, All stub articles, Human chromosome 11 gene stubs). ...

https://en.wikipedia.org/wiki/Archain

The SREBF1-SCAP complex is retained in the ER membrane by INSIG1 (insulin-induced gene 1 protein). When sterol levels are ... depleted, INSIG1 releases SCAP and the SREBF1-SCAP complex can be sorted into transport vesicles coated by the coatomer COPII ... In the Golgi apparatus, SREBF1 is cleaved and released as a transcriptionally active mature protein. It is then free to ... White fat cells secrete many proteins acting as adipokines such as resistin, adiponectin, leptin and apelin. An average human ...

https://en.wikipedia.org/wiki/Adipocyte

2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs ... 2004). "The human phosphatidylinositol phosphatase SAC1 interacts with the coatomer I complex". J. Biol. Chem. 278 (52): 52689- ... The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355-64. doi: ... The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347-55. doi: ...

https://en.wikipedia.org/wiki/SACM1L

The proteins lining the inner pore make up the NUP62 complex. On the nucleoplasm side, extra proteins associated with the ring ... the ancestral coatomer elements (ACE). To date, two classes of ACEs have been identified. ACE1 is a 28-helix domain found in ... Different sets of proteins associate on either ring, and some transmembrane proteins anchor the assembly to the lipid bilayer. ... Karyopherins can serve as an importin (transporting proteins into the nucleus) or an exportin (transporting proteins out of the ...

https://en.wikipedia.org/wiki/Nucleoporin

... including 6 ARF proteins and 11 ARF-like proteins, constitute a family of the RAS superfamily. The ARF proteins are categorized ... Eugster A, Frigerio G, Dale M, Duden R (August 2000). "COP I domains required for coatomer integrity, and novel interactions ... The ARF1 protein is localized to the Golgi apparatus and has a central role in intra-Golgi transport. Multiple alternatively ... ADP-ribosylation factor 1 is a protein that in humans is encoded by the ARF1 gene. ADP-ribosylation factor 1 (ARF1) is a member ...

https://en.wikipedia.org/wiki/ARF1

Regulator of G-protein signaling 2 is a protein that in humans is encoded by the RGS2 gene. It is part of a larger family of ... 2000). "RGS4 and RGS2 bind coatomer and inhibit COPI association with Golgi membranes and intracellular transport". Mol. Biol. ... Nlend MC, Bookman RJ, Conner GE, Salathe M (2002). "Regulator of G-protein signaling protein 2 modulates purinergic calcium and ... 1999). "Regulators of G protein signaling exhibit distinct patterns of gene expression and target G protein specificity in ...

https://en.wikipedia.org/wiki/RGS2

... coatomer protein MeSH D12.776.543.990.400.100 - dynamin i MeSH D12.776.543.990.400.200 - dynamin ii MeSH D12.776.543.990. ... gtp-binding protein alpha subunit, gi2 MeSH D12.776.543.325.100.300 - gtp-binding protein alpha subunits, gq-g11 MeSH D12.776. ... proto-oncogene proteins c-kit MeSH D12.776.543.750.060.186 - proto-oncogene proteins c-met MeSH D12.776.543.750.060.217 - proto ... q-snare proteins MeSH D12.776.543.512.249.500.500 - qa-snare proteins MeSH D12.776.543.512.249.500.500.700 - syntaxin 1 MeSH ...

https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.776.543)

The amino acid sequence of xenin is identical to the N-terminal end of cytoplasmic coatomer subunit alpha, from which xenin can ... Articles lacking in-text citations from February 2008, All articles lacking in-text citations, Protein pages needing a picture ... Like xenin, its amino acid sequence exactly matches the N-terminus of coatomer subunit alpha. Xenin promotes beta-cell survival ...

https://en.wikipedia.org/wiki/Xenin

ADP-ribosylation factor-like protein 1 is a protein that in humans is encoded by the ARL1 gene. The protein encoded by this ... Zhao L, Helms JB, Brunner J, Wieland FT (1999). "GTP-dependent binding of ADP-ribosylation factor to coatomer in close ... "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome ... "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/ ...

https://en.wikipedia.org/wiki/ARL1

"GTPase-activating proteins for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteins". ... 2000). "RGS4 and RGS2 bind coatomer and inhibit COPI association with Golgi membranes and intracellular transport". Mol. Biol. ... RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins ... Regulator of G protein signaling 4 protein is 37% identical to RGS1 and 97% identical to rat Rgs4. This protein negatively ...

https://en.wikipedia.org/wiki/RGS4

protein coding gene. Chr9:98445774-98470435 (+). 129S1/SvImJ MGP_129S1SvImJ_G0035156. protein coding gene. Chr9:99868736- ... protein coding gene. Chr9:94125761-94150768 (+). CAST/EiJ MGP_CASTEiJ_G0034151. protein coding gene. Chr9:98913310-98938476 (+) ... protein coding gene. Chr9:99108292-99132861 (+). C57BL/6NJ MGP_C57BL6NJ_G0035650. protein coding gene. Chr9:102733144-102757270 ... protein coding gene. Chr9:100122798-100147002 (+). NOD/ShiLtJ MGP_NODShiLtJ_G0034957. protein coding gene. Chr9:108195313- ...

http://www.informatics.jax.org/marker/MGI:1354962

Coatomer-dependent protein delivery to lipid droplets. Krishnakant G. Soni, Gonzalo A. Mardones, Rachid Sougrat, Elena Smirnova ... Coatomer-dependent protein delivery to lipid droplets. / Soni, Krishnakant G.; Mardones, Gonzalo A.; Sougrat, Rachid; Smirnova ... title = "Coatomer-dependent protein delivery to lipid droplets",. abstract = "Lipid droplets (LDs) are cytoplasmic organelles ... Soni, K. G., Mardones, G. A., Sougrat, R., Smirnova, E., Jackson, C. L., & Bonifacino, J. S. (2009). Coatomer-dependent protein ...

https://academia.kaust.edu.sa/en/publications/coatomer-dependent-protein-delivery-to-lipid-droplets

Coatomer Protein / genetics * DNA Footprinting * DNA-Binding Proteins / genetics * DNA-Binding Proteins / metabolism ... Although Qrx and Rx/Rax show similar DNA binding properties in vitro, the two proteins demonstrate distinct target selectivity ...

https://pubmed.ncbi.nlm.nih.gov/15028672/

These clathrin and coatomer proteins, however, are in direct contact with the cell cytosol (Figure 1, panel D; Figure 2, panel ... Coatomer proteins mediate transport within the Golgi complex and between the Golgi complex and ER (42). Although the sizes of ... Coat proteins: shaping membrane transport. Nat Rev Mol Cell Biol. 2003;4:409-14. DOIPubMedGoogle Scholar ... The SARS coronavirus nucleocapsid protein-forms and functions. Antiviral Res. 2014;103:39-50. DOIPubMedGoogle Scholar ...

https://wwwnc.cdc.gov/eid/article/27/4/20-4337_article

ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16. PHA03247. Location:2 → 291. ... General protein information Go to the top of the page Help Preferred Names. protein transport protein Sec16A. NP_694765.2. *EC ... PHA03247; large tegument protein UL36; Provisional. * XM_030249768.2 → XP_030105628.2 protein transport protein Sec16A isoform ... PHA03247; large tegument protein UL36; Provisional. * XM_011239073.3 → XP_011237375.1 protein transport protein Sec16A isoform ...

https://www.ncbi.nlm.nih.gov/gene/?term=227648

Molecular Function: protein transporter activity (GO:0008565). WD-40 repeat. 25. 5. 129320. Coatomer WD associated region. - ... Protein prediction analysis (2) Protein prediction analysis (2) Prediction based on longest six frame method >SGN-P232371 (71 ... Coatomer WD associated region. - Biological Process: intracellular protein transport (GO:0006886). - ... coatomer protein complex, subunit beta 2 (beta prime), putative , chr1:30090803-30096842 FORWARD. ...

https://www.sgn.cornell.edu/search/unigene.pl?unigene_id=SGN-U290245

PROTEÍNA COATOMER COATOMER PROTEIN PROTEINA COATOMERA PROTEÍNA P120 ATIVADORA DE GTPASE P120 GTPASE ACTIVATING PROTEIN PROTEINA ... RAN GTP-BINDING PROTEIN PROTEINA DE ENLACE-GTP RAN PROTEÍNA RHO3 DE LIGAÇÃO A GTP RHOB GTP-BINDING PROTEIN PROTEINA DE ENLACE- ... RAB2 GTP-BINDING PROTEIN PROTEINA DE ENLACE-GTP RAB2 PROTEÍNA RAB3A DE LIGAÇÃO A GTP RAB3A GTP-BINDING PROTEIN PROTEINA DE ... RAB GTP-BINDING PROTEINS PROTEINAS DE ENLACE-GTP RAB PROTEÍNAS RAB1 DE LIGAÇÃO A GTP RAB1 GTP-BINDING PROTEINS PROTEINAS DE ...

https://decs.bvs.br/P/news2000pie.htm

Ten previously uncharacterized proteins were identified as significant in these pathways, showing how the systems can feed ... Here we show that such models can be derived from an integrated gene/protein network generated from three different types of ... Although numerous fundamental aspects of development have been uncovered through the study of individual genes and proteins, ... By integrating information on how proteins interact with each other, how genes are expressed and the effect of knocking-down ...

https://www.nature.com/articles/nature03876?error=cookies_not_supported&code=938ab6c6-e6ff-45e9-bfb8-25c813054283

COATOMER PROTEIN PROTEINA COATOMERA PROTEÍNA COATOMER COILED BODIES CUERPOS ENROLLADOS CORPOS ESPIRALADOS ... PROTEIN RENATURATION RENATURACION DE PROTEINA RENATURAÇÃO PROTÉICA PROTEIN STRUCTURE, QUATERNARY ESTRUCTURA CUATERNARIA DE ... SOS1 PROTEIN PROTEINA SOS1 PROTEÍNA SOS1 SPERM INJECTIONS, INTRACYTOPLASMIC INYECCIONES DE ESPERMA INTRACITOPLASMATICAS ... CDC42 GTP-BINDING PROTEIN, YEAST PROTEINA DE ENLACE-GTP CDC42 DE LEVADURA PROTEÍNA CDC42 DE LEVEDURA DE LIGAÇÃO A GTP ...

https://decs2014.bvsalud.org/I/news2000iep.htm

https://decs2013.bvsalud.org/I/news2000iep.htm

https://decs2010.bvsalud.org/I/news2000iep.htm

https://decs2018.bvsalud.org/I/news2000iep.htm

... for COATOMER PROTEIN & COATOMER SUBUNIT EPSILON-COP use COATOMER PROTEIN (NM) 1994-1999; for ACRN1 PROTEIN, & RET1 PROTEIN use ... Coatomer epsilon Subunit. Coatomer gamma Subunit. Coatomer zeta Subunit. HEP COP. HEP-COP. Protein, ARCN1. Ret1 Protein. alpha- ... 2000; COATOMER PROTEIN & COATOMER SUBUNIT EPSILON-COP were indexed under MEMBRANE PROTEINS 1994-1999; RET1 PROTEIN & ZETA-COP ... ARCN1 Protein. Archain. Coatomer Subunit epsilon COP. Coatomer Subunit epsilon-COP. Coatomer alpha Subunit. Coatomer beta ...

https://decs.bvsalud.org/en/ths/resource/?id=34500

https://decs2008.bvsalud.org/I/news2000iep.htm

https://decs2012.bvsalud.org/I/news2000iep.htm

https://decs2007.bvsalud.org/I/news2000iep.htm

https://decs2017.bvsalud.org/I/news2000iep.htm

https://decs2020.bvsalud.org/I/news2000iep.htm

https://decs2015.bvsalud.org/I/news2000iep.htm

https://decs2009.bvsalud.org/I/news2000iep.htm

https://decs2016.bvsalud.org/I/news2000iep.htm

https://decs2019.bvsalud.org/I/news2000iep.htm

https://decs2011.bvsalud.org/I/news2000iep.htm

Coatomer protein complex, beta prime. 6e-99. At1g52360. coatomer protein complex, subunit beta 2 (beta prime), putative. O.I.. ... Coatomer gamma subunit (Gamma-coat protein)(Gamma-COP). 1e-25. At4g34450. coatomer gamma-2 subunit, putative / gamma-2 coat ... Nonaspanin (TM9SF) family protein. 2e-39. At5g10840. endomembrane protein 70, putative. O.I.. H.G.. S.X.. Please select. KEGG ( ... Nonaspanin (TM9SF) family protein. 4e-107. At3g13772. endomembrane protein 70, putative. O.I.. H.G.. S.X.. Please select. KEGG ...

http://webs2.kazusa.or.jp/kagiana/cgi-bin/gcft.cgi?query=Os05g0295300&organism=osa&option=1

These vesicles have specific coat proteins (such as clathrin or coatomer) that are important for cargo selection and direction ... Click on the protein counts, or double click on taxonomic names to display all proteins containing Alpha_adaptinC2 domain in ... AP (adaptor protein) complexes are found in coated vesicles and clathrin-coated pits. AP complexes connect cargo proteins and ... Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to ...

https://smart.embl.de/smart/do_annotation.pl?DOMAIN=Alpha_adaptinC2&START=503&END=627&E_VALUE=4.21e-37&TYPE=SMART&BLAST=IKPSSILPVTVYDQHGFRVLFHFARDPLPGRSDVLVVVVSMLSTAPQPIRNIVFQSAVPKVMKVRLQPPSGTELPAFNPIVHPSAITQVLLLANPQKEKVRLRYKLIFTMGDQTYNEMGDVDQFP

coatomer protein complex, subunit zeta 2. Ssc.4221.1.S1_at. 0.49. SEC31L2. SEC31 homolog B (S. cerevisiae). Ssc.31182.1.A1_at. ... heat shock 60kDa protein 1 (chaperonin). Ssc.6719.1.A1_at. 1.83. HSPH1. heat shock 105kDa/110kDa protein 1. Ssc.1231.1.A1_at. ... membrane protein, palmitoylated 1, 55kDa. Ssc.19356.1.S1_at. 0.57. PPBP. pro-platelet basic protein (chemokine (C-X-C motif) ... interferon, gamma-inducible protein 16. Ssc.10884.1.A1_at. 3.41. IFI6. Interferon, alpha-inducible protein 6. Ssc.20101.1.S1_at ...

https://ijbs.com/v07p0947.htm

These coatomers contain two large Adaptin proteins (γ, α, δ, or ε and β1, β2, β3, or β4, respectively) that are noncovalently ... These coatomers contain two large Adaptin proteins (γ, α, δ, or ε and β1, β2, β3, or β4, respectively) that are noncovalently ... Two sorting signals are tyrosine-based and dileucine-based signals that interact with heterotetrameric adaptor protein ... Two sorting signals are tyrosine-based and dileucine-based signals that interact with heterotetrameric adaptor protein ...

https://www.bdbiosciences.com/en-eu/products/reagents/microscopy-imaging-reagents/immunofluorescence-reagents/purified-mouse-anti-adaptin.610381

https://wwwnc-origin.cdc.gov/eid/article/27/4/20-4337_article

The coatomer protein complex zeta 1 (COPZ1) represents a non-oncogene addiction for thyroid cancer (TC); its depletion impairs ... The coatomer protein complex zeta 1 (COPZ1) represents a non-oncogene addiction for thyroid cancer (TC); its depletion impairs ...

https://air.unimi.it/handle/2434/713942

C. elegans ceh-10 homeo domain containing homolog ...

https://mousespinal.brain-map.org/imageseries/list/1.html?clear=true&contains=false&excludeFail=on&gene_term=C&odir=desc&order=expressionRostralMedial&searchSym=t

COATOMER PROTEIN and ADP-RIBOSYLATION FACTOR 1 are principle components of COAT PROTEIN COMPLEX I and are involved in vesicle transport between the ENDOPLASMIC RETICULUM and the GOLGI APPARATUS . (bvsalud.org)
Proteins synthesized on the ribosome and processed in the endoplasmic reticulum are transported from the Golgi apparatus to the trans-Golgi network (TGN), and from there via small carrier vesicles to their final destination compartment. (embl.de)
GGAs (Golgi-localising, Gamma-adaptin ear domain homology, ARF-binding proteins) are a family of monomeric clathrin adaptor proteins that are conserved from yeasts to humans. (embl.de)
Brefeldin A (BFA) is a fungal metabolite that disassembles the Golgi apparatus into tubular networks and causes the dissociation of coatomer proteins from Golgi membranes. (elsevier.com)
We have previously shown that an additional effect of BFA is to stimulate the ADP-ribosylation of two cytosolic proteins of 38 and 50 kDa (brefeldin A-ADP-riboslyated substrate (BARS)) and that this effect greatly facilitates the Golgi-disassembling activity of the toxin. (elsevier.com)
The movement of proteins takes place by transfer vesicles that bud off from the rough endoplasmic reticulum or Golgi apparatus and fuse with the Golgi, lysosomes or cell membrane. (musc.edu)
Adaptor Protein CD2AP and L-type Lectin LMAN2 Regulate Exosome Cargo Protein Trafficking through the Golgi Complex. (musc.edu)
THE ADP-ribosylation factor ARF is a small GTP-binding protein that is involved in the transport of vesicles between the endo-plasmic reticulum (ER) and Golgi complex and within the Golgi complex itself1-4. (springernature.com)
Geal contains a domain that is similar to a domain of Sec7, a protein necessary for intra-Golgi transport. (springernature.com)
ER resident proteins could then attain their steady-state localization by being retained in the ER or retrieved from the Golgi. (rupress.org)
Here, we show that, in the absence of a Golgi compartment in Giardia, proteins destined for secretion are directly sorted and packaged at specialized ER regions enriched in COPII coatomer complexes and ceramide. (conicet.gov.ar)
Alternatively, a leucine, of the MPRs in Rosenthal, D Kety, S.S. Biodiversity see Genetic packaged into coatomer and transport through containing these vacuolar transferred to the Golgi where it to be recruited Department of Physiology, and fusion of acetyl glucosaminephosphate to tails of ALP mannose residues on. (carrerasolar.com)
W. E. ( I 998) Trends Received 2 March 2000 0 2000 Biochemical Society 512 green fluorescent protein mutagenesis, Sar1 COP, coatomer protein ER , endoplasmic reticulum GA, Golgi apparatus GFP, green fluorescent protein VTC, vesicular-tubular clusters or intermediate. (silverchair.com)

Here we demonstrate that ATGL and ADRP, but not TIP47, are delivered to LDs by a pathway mediated by the COPI and COPII coatomer proteins and their corresponding regulators. (edu.sa)
Vesicle trafficking.Coat protein I (COPI) coatomer. (ntu.edu.sg)

A stack of flattened vesicles that functions in posttranslational processing and sorting of proteins, receiving them from the rough ENDOPLASMIC RETICULUM and directing them to secretory vesicles, LYSOSOMES, or the CELL MEMBRANE. (musc.edu)
CAT, chloramphenicol acetyltransferase CRE, cAMP-response element CREB, CRE-binding protein CRU, cAMP response unit ER , endoplasmic reticulum FKHR, forkhead in rhabdosarcoma G6Pase. (silverchair.com)
AAA protease ABC transporter prohibitin proteolysis ER , endoplasmic reticulum Assembly and Repair of Membrane-Bound Electron Transport Complexes AAA proteases of mitochondria: quality control of membrane proteins and regulatory. (silverchair.com)

Three independent markers of bulk flow transport out of the ER indicate that in the absence of an ER export signal, molecules are inefficiently captured into coat protein complex II (COPII)-coated vesicles. (rupress.org)
In the absence of Erv29p, a membrane protein that facilitates gpαf transport ( Belden and Barlowe, 2001 ), gpαf is packaged into COPII vesicles as inefficiently as soluble bulk flow markers. (rupress.org)
We also found that a plasma membrane protein, the general amino acid permease (Gap1p), is enriched approximately threefold in COPII vesicles relative to membrane phospholipids. (rupress.org)

BARS shares high homology with two known proteins, C-terminal-binding protein 1 (CtBP1) and CtBP2. (elsevier.com)

Several proteins in this centriole biogenesis pathway correspond to established primary microcephaly (MCPH) genes, and multiple model organism studies hypothesize PPP1R35 as a candidate MCPH gene. (bvsalud.org)
siRNA targeting protein tyrosine phosphatase-1B (PTP1B) - Efficient sequence specific gene silencing is possible through the use of siRNA technology. (patentsencyclopedia.com)
2007. Caspase-resistant VirD2 protein provides enhanced gene delivery and expression in plants . (hutton.ac.uk)

Our study suggests that the ER-exit sites and the perinuclear ER-membranes are capable of performing protein-sorting functions. (conicet.gov.ar)

In particular, the SMN (survival motor neuron) protein complex is required for addition of the core Sm proteins to the snRNP. (biologists.com)
Here we identify a protein (Gea1) from Saccharomyces cerevisiae that is a component of a complex possessing guanine-nucleotide-exchange activity for ARF. (springernature.com)
XIII" YMR047C 3 13 3 YMR047C "Nuclear pore complex protein that is member of GLFG repeat-containing family of nucleoporins and is,XIII" YMR049C 3 13 4 YMR049C "Ymr049cp,XIII" YMR051C 3 13 5 YMR051C "TyA Gag protein. (davidson.edu)

The role of coat proteins in the biosynthesis of secretory proteins. (wikidata.org)
Here, we show that efficient transport of membrane and secretory proteins from the ER of Saccharomyces cerevisiae requires concentrative and signal-mediated sorting. (rupress.org)
A soluble secretory protein, glycosylated pro-α-factor (gpαf), was enriched ∼20 fold in these vesicles relative to bulk flow markers. (rupress.org)
Proteins of the secretory pathway are shuttled between organelles in membrane-bound transport vesicles that are generated by cytoplasmic coat proteins. (rupress.org)
An alternative model postulates that secretory cargo proteins possess positively acting sorting signals that promote their enrichment in transport vesicles. (rupress.org)

Microarray analysis revealed that HP-PRRSV infection has affected PAMs in expression of the important genes involved in cytoskeleton and exocytosis organization, protein degradation and folding, intracellular calcium and zinc homeostasis. (ijbs.com)

AP complexes connect cargo proteins and lipids to clathrin at vesicle budding sites, as well as binding accessory proteins that regulate coat assembly and disassembly (such as AP180, epsins and auxilin). (embl.de)
Steroid receptor RNA activator-protein/coat protein. (ntu.edu.sg)

Although numerous fundamental aspects of development have been uncovered through the study of individual genes and proteins, system-level models are still missing for most developmental processes. (nature.com)

Protein phosphatase 1 regulatory subunit 35 (PPP1R35) encodes a centrosomal protein required for recruiting microtubule-binding elongation machinery. (bvsalud.org)

Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. (embl.de)
AP (adaptor protein) complexes are found in coated vesicles and clathrin-coated pits. (embl.de)
Adaptins recognise and bind to clathrin through their hinge region (clathrin box), and recruit accessory proteins that modulate AP function through their C-terminal ear (appendage) domains. (embl.de)

Mutation of a diacidic sequence present in the COOH-terminal cytosolic domain of Gap1p eliminated concentrative sorting of this protein. (rupress.org)

and protein localization to plasma membrane. (nih.gov)
AP is the protein is mediated internalization from the plasma membrane domain, ARF binding N V N coats and bind lysosomal proteases. (carrerasolar.com)

The carboxyl-terminal appendage of the alpha subunit regulates translocation of endocytic accessory proteins to the bud site. (embl.de)

The role of GTP-binding proteins in transport along the exocytic pathway. (wikidata.org)

A number of proteins have been shown to localize to the surface of lipid droplets, including lipases such as adipose triglyceride lipase (ATGL) and the PAT-domain proteins ADRP (adipophilin) and TIP47, but the mechanism by which they are targeted to LDs is not known. (edu.sa)
Our understanding of protein and lipid trafficking in eukaryotic cells has been challenged by the finding of different forms of compartmentalization and cargo processing in protozoan parasites. (conicet.gov.ar)

XV" YOL105C 1 15 18 YOL105C "Putative integral membrane protein containing novel cysteine motif. (davidson.edu)

We propose that Geal and ARNO, a human protein with a homologous Sec7 domain7, are members of a new family of ARF guanine-nucleotide exchange factors. (springernature.com)

Coatomer subunit beta'-2 OS=Oryza sativa subsp. (cornell.edu)

Multiple and stepwise interactions between coatomer and ADP-ribosylation factor-1 (Arf1)-GTP. (mpg.de)

We assessed the overall predictive value of such molecular machine models by dynamic localization of ten previously uncharacterized proteins within the living embryo. (nature.com)
Embryonic localization patterns of GFP-tagged fusion proteins analysed by time-lapse microscopy are largely consistent with model predictions. (nature.com)

Selective inclusion of proteins into these transport vesicles is thought to be the principle mechanism that restricts proteins to individual organelles ( Schekman and Orci, 1996 ). (rupress.org)

contains a zinc finger,XV" YOL091W 1 15 16 YOL091W "involved in sporulation,XV" YOL103W-B 1 15 17 YOL103W-B "TyB Gag-Pol protein. (davidson.edu)

Anatomy3

Chemicals and Drugs4

Coupling of coat assembly and vesicle budding to packaging of putative cargo receptors. (1/266)

Structural and functional analysis of the ARF1-ARFGAP complex reveals a role for coatomer in GTP hydrolysis. (2/266)

Clathrin and two components of the COPII complex, Sec23p and Sec24p, could be involved in endocytosis of the Saccharomyces cerevisiae maltose transporter. (3/266)

Inhibition of secretion by 1,3-Cyclohexanebis(methylamine), a dibasic compound that interferes with coatomer function. (4/266)

Nef-induced CD4 degradation: a diacidic-based motif in Nef functions as a lysosomal targeting signal through the binding of beta-COP in endosomes. (5/266)

p24 and p23, the major transmembrane proteins of COPI-coated transport vesicles, form hetero-oligomeric complexes and cycle between the organelles of the early secretory pathway. (6/266)

Osmotically induced cell volume changes alter anterograde and retrograde transport, Golgi structure, and COPI dissociation. (7/266)

GTP-dependent binding of ADP-ribosylation factor to coatomer in close proximity to the binding site for dilysine retrieval motifs and p23. (8/266)

Coatomer Protein

Coat Protein Complex I

Golgi Apparatus

Coated Vesicles

COP-Coated Vesicles

ADP-Ribosylation Factor 1

ADP-Ribosylation Factors

Coupling of coat assembly and vesicle budding to packaging of putative cargo receptors. (1/266)

Structural and functional analysis of the ARF1-ARFGAP complex reveals a role for coatomer in GTP hydrolysis. (2/266)

Clathrin and two components of the COPII complex, Sec23p and Sec24p, could be involved in endocytosis of the Saccharomyces cerevisiae maltose transporter. (3/266)

Inhibition of secretion by 1,3-Cyclohexanebis(methylamine), a dibasic compound that interferes with coatomer function. (4/266)

Nef-induced CD4 degradation: a diacidic-based motif in Nef functions as a lysosomal targeting signal through the binding of beta-COP in endosomes. (5/266)

p24 and p23, the major transmembrane proteins of COPI-coated transport vesicles, form hetero-oligomeric complexes and cycle between the organelles of the early secretory pathway. (6/266)

Osmotically induced cell volume changes alter anterograde and retrograde transport, Golgi structure, and COPI dissociation. (7/266)

GTP-dependent binding of ADP-ribosylation factor to coatomer in close proximity to the binding site for dilysine retrieval motifs and p23. (8/266)

COPA - Coatomer subunit alpha - Homo sapiens (Human) - COPA gene & protein

Copb2 - Coatomer subunit beta - Rattus norvegicus (Rat) - Copb2 gene & protein

COPE Full-Length MS Protein Standard - Creative Proteomics

PGSC0003DMT400015461 protein (Solanum tuberosum) - STRING network view

An endoplasmic reticulum retrieval signal partitions human foamy virus maturation to intracytoplasmic membranes

Anti-Sar1 (secretion-associated and Ras-related protein 1) antibody, marker of ER

anti-COPB antibody [maD] | GeneTex

Coatomer subunit delta (COPD) antibody | acris-antibodies.com

Characterisation of a delta-COP homologue in the malaria paras...

Reactome | RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle]

Si013290m protein (Setaria italica) - STRING network view

COPI vesicles accumulating in the presence of a GTP restricted arf1 mutant are depleted of anterograde and retrograde cargo |...

Exclusion of Golgi Residents from Transport Vesicles Budding from Golgi Cisternae in Intact Cells | Journal of Cell Biology |...

Calpain-8

JoVE Search Results: Coat Proteins

Coatomer beta subunit, C-terminal (IPR011710) | InterPro | EMBL-EBI

COPI Transport - Victor Hsu

Propulse NG QrX Tips (100) | Kays Medical

beta COP I肽(ab4933)|Abcam中国

Anti-alpha COP I 抗体 (ab2913) | アブカム

QRX Technology Group Inc.

PROSITE

Roles of singleton tryptophan motifs in COPI coat stability and vesicle tethering. | Department of Molecular Biology

ARF-GAP-mediated interaction between the ER-Golgi v-SNAREs and the COPI coat :: MPG.PuRe

Steroids And What They Do To You - QRX Pharma

Theater review: Lost family tries to get back on track in Boston Courts Colony Collapse

Tethering assays for COPI vesicles mediated by golgins<...

Warehouse Pathway - COPI-independent Golgi-to-ER retrograde traffic

Molecular evolution of the vesicle coat component betaCOP in Toxoplasma gondii.

Reactome | ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi

Grozījumi likumā Par bijušās Valsts drošības komitejas dokumentu saglabāšanu, izmantošanu un personu sadarbības fakta ar VDK...

Maxines Challenge Advanced Stack!

10 Best Nootropics For Studying Plus A Surefire Study Stack

Cell-tech Stack - AnabolicMinds.com

Differential roles of ArfGAP1, ArfGAP2, and ArfGAP3 in COPI trafficking | JCB

Control of Protein Homeostasis in the Early Secretory Pathway Current Status and Challenges - Université de Rennes 1

Salată caldă cu cartofi copţi şi brânză de capră | Revista Flacara

Kumaha urang pendak sareng jalma-jalma anu henteu iman? - Garéja Allah sadunya Switzerland

Anu vehviläinen ikä - dangdut indonesia production 766

Fondazione Golgi Cenci

Summary information of cluster CELK03426

Prof. Dr. Julien Béthune, HAW Hamburg

Localisation of the Temperature-Sensitive Defect in the Nucleoprotein of an Influenza A/FPV/Rostock/34 Virus - PubMed

囊泡 - 维基百科，自由的百科全书

RCSB PDB - 1FQE: CRYSTAL STRUCTURES OF MUTANT (K206A) THAT ABOLISH THE DILYSINE INTERACTION IN THE N-LOBE OF HUMAN...

Endogenous hHK3 localizes to the Golgi complex. The loc | Open-i

Copg - PrimePCR Assay and Template | Life Science | Bio-Rad

bulking natty stack - AnabolicMinds.com

5623 - fcatch support fstacks options for more detailed backtraces

ADP ribosylation factor 6 regulates neuronal migration in the developing cerebral cortex through FIP3/arfophilin-1-dependent...

Kinase Family SCYL - WikiKinome

Lecture 13 11 - /02/07 Golgi Structure/Function Lysosome Exocytosis Glycosylation Protects lysosome membrane proteins from...

Irradiation-induced protein inactivation reveals Golgi enzyme cycling to cell periphery | Journal of Cell Science

2EQN | Genus

Hakkers HUSS, Hybrid, and H4GS Stack Routine Reverse Engineered

COPE (gene)

COPG

COPA (gene)

COPG2

COPZ1

COPB2

COPI

COPB1

Chylomicron retention disease

ARF5