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Coagulation Protein DisordersBlood CoagulationBlood Coagulation FactorsVitamin KDatabases, ProteinFactor IXProthrombinSequence Analysis, ProteinProthrombin TimeFactor XCarbon-Carbon LigasesProteinsDisseminated Intravascular CoagulationFactor XIBlood Protein DisordersProtein C1-Carboxyglutamic AcidThromboplastinFactor VIIIFactor VBlood Coagulation DisordersThrombinBlood Coagulation TestsComputational BiologyProtein FoldingProtein ConformationProteomeAlgorithmsSoftware
Coagulation Protein Disorders
Hemorrhagic and thrombotic disorders resulting from abnormalities or deficiencies of coagulation proteins.
Blood Coagulation
The process of the interaction of BLOOD COAGULATION FACTORS that results in an insoluble FIBRIN clot.
Blood Coagulation Factors
Endogenous substances, usually proteins, that are involved in the blood coagulation process.
Vitamin K
A lipid cofactor that is required for normal blood clotting. Several forms of vitamin K have been identified: VITAMIN K 1 (phytomenadione) derived from plants, VITAMIN K 2 (menaquinone) from bacteria, and synthetic naphthoquinone provitamins, VITAMIN K 3 (menadione). Vitamin K 3 provitamins, after being alkylated in vivo, exhibit the antifibrinolytic activity of vitamin K. Green leafy vegetables, liver, cheese, butter, and egg yolk are good sources of vitamin K.
Databases, Protein
Databases containing information about PROTEINS such as AMINO ACID SEQUENCE; PROTEIN CONFORMATION; and other properties.
Factor IX
Storage-stable blood coagulation factor acting in the intrinsic pathway. Its activated form, IXa, forms a complex with factor VIII and calcium on platelet factor 3 to activate factor X to Xa. Deficiency of factor IX results in HEMOPHILIA B (Christmas Disease).
Prothrombin
A plasma protein that is the inactive precursor of thrombin. It is converted to thrombin by a prothrombin activator complex consisting of factor Xa, factor V, phospholipid, and calcium ions. Deficiency of prothrombin leads to hypoprothrombinemia.
Sequence Analysis, Protein
A process that includes the determination of AMINO ACID SEQUENCE of a protein (or peptide, oligopeptide or peptide fragment) and the information analysis of the sequence.
Prothrombin Time
Clotting time of PLASMA recalcified in the presence of excess TISSUE THROMBOPLASTIN. Factors measured are FIBRINOGEN; PROTHROMBIN; FACTOR V; FACTOR VII; and FACTOR X. It is used for monitoring anticoagulant therapy with COUMARINS.
Factor X
Storage-stable glycoprotein blood coagulation factor that can be activated to factor Xa by both the intrinsic and extrinsic pathways. A deficiency of factor X, sometimes called Stuart-Prower factor deficiency, may lead to a systemic coagulation disorder.
Carbon-Carbon Ligases
Enzymes that catalyze the joining of two molecules by the formation of a carbon-carbon bond. These are the carboxylating enzymes and are mostly biotinyl-proteins. EC 6.4.
Proteins
Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.
Disseminated Intravascular Coagulation
A disorder characterized by procoagulant substances entering the general circulation causing a systemic thrombotic process. The activation of the clotting mechanism may arise from any of a number of disorders. A majority of the patients manifest skin lesions, sometimes leading to PURPURA FULMINANS.
Factor XI
Stable blood coagulation factor involved in the intrinsic pathway. The activated form XIa activates factor IX to IXa. Deficiency of factor XI is often called hemophilia C.
Blood Protein Disorders
Protein C
A vitamin-K dependent zymogen present in the blood, which, upon activation by thrombin and thrombomodulin exerts anticoagulant properties by inactivating factors Va and VIIIa at the rate-limiting steps of thrombin formation.
1-Carboxyglutamic Acid
Found in various tissues, particularly in four blood-clotting proteins including prothrombin, in kidney protein, in bone protein, and in the protein present in various ectopic calcifications.
Thromboplastin
Constituent composed of protein and phospholipid that is widely distributed in many tissues. It serves as a cofactor with factor VIIa to activate factor X in the extrinsic pathway of blood coagulation.
Factor VIII
Blood-coagulation factor VIII. Antihemophilic factor that is part of the factor VIII/von Willebrand factor complex. Factor VIII is produced in the liver and acts in the intrinsic pathway of blood coagulation. It serves as a cofactor in factor X activation and this action is markedly enhanced by small amounts of thrombin.
Factor V
Heat- and storage-labile plasma glycoprotein which accelerates the conversion of prothrombin to thrombin in blood coagulation. Factor V accomplishes this by forming a complex with factor Xa, phospholipid, and calcium (prothrombinase complex). Deficiency of factor V leads to Owren's disease.
Blood Coagulation Disorders
Hemorrhagic and thrombotic disorders that occur as a consequence of abnormalities in blood coagulation due to a variety of factors such as COAGULATION PROTEIN DISORDERS; BLOOD PLATELET DISORDERS; BLOOD PROTEIN DISORDERS or nutritional conditions.
Thrombin
An enzyme formed from PROTHROMBIN that converts FIBRINOGEN to FIBRIN.
Blood Coagulation Tests
Laboratory tests for evaluating the individual's clotting mechanism.
Computational Biology
A field of biology concerned with the development of techniques for the collection and manipulation of biological data, and the use of such data to make biological discoveries or predictions. This field encompasses all computational methods and theories for solving biological problems including manipulation of models and datasets.
Protein Folding
Processes involved in the formation of TERTIARY PROTEIN STRUCTURE.
Protein Conformation
The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).
Proteome
The protein complement of an organism coded for by its genome.
Algorithms
A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.
Software
Sequential operating programs and data which instruct the functioning of a digital computer.

Deficiency of natural anticoagulant proteins C, S, and antithrombin in portal vein thrombosis: a secondary phenomenon? (1/21)

BACKGROUND: Hereditary deficiencies of natural anticoagulant proteins are implicated in the pathogenesis of portal vein thrombosis (PVT). Secondary deficiencies of these proteins have also been reported in PVT, making interpretation of concentrations difficult. AIMS: To characterise the coagulation profiles in adult patients with PVT and to investigate the possible mechanisms of natural anticoagulant protein deficiency. PATIENTS: Twenty nine adult patients with portal hypertension caused by PVT, and normal biochemical liver function tests. METHODS: Routine coagulation profiles and concentrations of proteins C, S, and antithrombin were measured; where indicated, corresponding concentrations in parents were also measured. Synchronous peripheral and hepatic or splenic vein concentrations were compared in seven patients undergoing interventional procedures, as were peripheral concentrations before and after shunt surgery in three patients. RESULTS: Deficiencies of one or more of the natural anticoagulant proteins occurred in 18 patients (62%), with six patients having combined deficiency of all three proteins. There were strong correlations between prothrombin and partial thromboplastin time ratios and concentrations of natural anticoagulant proteins. Family studies in nine cases of anticoagulant protein deficiency revealed possible hereditary deficiency in only three cases, and significantly lower concentrations of anticoagulant proteins in all PVT cases compared with parents. Levels of anticoagulant proteins tended to be lower in hepatic veins but higher in splenic veins compared with peripheral vein concentrations. Peripheral concentrations decreased after shunt surgery. CONCLUSIONS: Deficiency of natural anticoagulant proteins is common in PVT and is probably a secondary phenomenon in most cases, occurring as part of a global disturbance of coagulation variables. The mechanism for this remains unclear but may result from a combination of reduced hepatic blood flow and portosystemic shunting itself.  (+info)

Studies of the human factor VIII/von Willebrand factor protein. III. Qualitative defects in von Willebrand's disease. (2/21)

The Factor VIII/von Willebrand factor protein was characterized in two unrelated patients with von Willebrand's disease in whom procoagulant and Factor VIII/von Willebrand factor antigen levels were normal. In both patients evidence of an abnormal protein was observed on crossed antigen-antibody electrophoresis. In one patient the Factor VIII/von Willebrand factor protein eluted from Sepharose 4B in a position and distribution identical to normal with normal levels of procoagulant activity and antigen. However, the partially purified Factor VIII/von Willebrand factor protein had markedly reduced von Willebrand factor activity in a ristocetin assay. In the second patient the peak of Factor VIII/von Willebrand factor protein, antigen, and procoagulant activity eluted from a Sepharose 4B column with an estimated molecular weight of approximately half that of normal. This protein had no von Willebrand factor activity. In both patients the reduced Factor VIII/von Willebrand factor protein subunit was indistinguishable from normal on polyacrylamide gel electrophoresis. These studies indicate that in some patients with von Willebrand's disease there is a qualitative defect of the Factor VII/von Willebrand factor protein; the total amount of protein, antigen, and procoagulant activity are normal while the von Willebrand factor activity is deficient.  (+info)

Coagulation and bleeding disorders: review and update. (3/21)

Hemostasis is initiated by injury to the vascular wall, leading to the deposition of platelets adhering to components of the subendothelium. Platelet adhesion requires the presence of von Willebrand factor and platelet receptors (IIb/IIIa and Ib/IX). Additional platelets are recruited to the site of injury by release of platelet granular contents, including ADP. The "platelet plug" is stabilized by interaction with fibrinogen. In this review, I consider laboratory tests used to evaluate coagulation, including prothrombin time, activated partial thromboplastin time, thrombin time, and platelet count. I discuss hereditary disorders of platelets and/or coagulation proteins that lead to clinical bleeding as well as acquired disorders, including disseminated intravascular coagulation and acquired circulating anticoagulants.  (+info)

Activated partial thromboplastin time as a screening test of minor or moderate coagulation factor deficiencies for canine plasma: sensitivity of different commercial reagents. (4/21)

To determine the sensitivity for detection of coagulation factor deficiencies by commercial reagents for canine plasma, 5 commercial activated partial thromboplastin time (APTT) reagents with different types of contact activator and phospholipid of various origin were examined. Thirty canine plasma samples with minor or moderate deficiencies of coagualition factors that influence the APTT were examined. Significant differences were found for the sensitivity of various reagents, but no correlation was found with the type of contact activator. Following the test instructions provided by the manufacturers, the number of APTT results that were prolonged beyond the reference range varied between 20 and 30 (sensitivity = 0.67-1.00); the number of corresponding results using a standardized test protocol varied between 19 and 28 (sensitivity: 0.63-0.93). The most sensitive reagent contained kaolin as a contact activator and a human placental thromboplastin. The results of this study indicate that the APTT test optimized for human plasma is also a sensitive screening test of the intrinsic system of canine plasma, provided that a suitable reagent is used.  (+info)

Fibrinogen Ales: a homozygous case of dysfibrinogenemia (gamma-Asp(330)-->Val) characterized by a defective fibrin polymerization site "a". (5/21)

Congenital homozygous dysfibrinogenemia was diagnosed in a man with a history of 2 thrombotic strokes before age 30. His hemostatic profile was characterized by a dramatically prolonged plasma thrombin clotting time, and no clotting was observed with reptilase. Complete clotting of the abnormal fibrinogen occurred after a prolonged incubation of plasma with thrombin. The release of fibrinopeptides A and B by thrombin and of fibrinopeptide A by reptilase were both normal. Thrombin-induced fibrin polymerization was impaired, and no polymerization occurred with reptilase. The polymerization defect was characterized by a defective site "a," resulting in an absence of interaction between sites A and a, indicated by the lack of fragment D(1) (or fibrinogen) binding to normal fibrin monomers depleted in fibrinopeptide A only (Des-AA fm). By SDS-PAGE, the defect was detected on the gamma-chain and in its fragment D(1). The molecular defect determined by analysis of genomic DNA showed a single base change (A-->T) in exon VIII of the gamma-chain. The resulting change in the amino acid structure is gamma 330 aspartic acid (GAT) --> valine (GTT). It is concluded that the residue gamma-Asp(330) is essential for the normal functioning of the polymerization site a on the fibrinogen gamma-chain.  (+info)

Decreased coagulability has no clinically relevant effect on atherogenesis: observations in individuals with a hereditary bleeding tendency. (6/21)

BACKGROUND: Hemostasis affects ischemic cardiovascular disease through its role in formation of occluding arterial thrombi. Several studies suggest that hemostasis also might play a role in atherogenesis. We investigated whether individuals with an inherited bleeding tendency are protected against development of atherosclerosis. METHODS AND RESULTS: A total of 76 individuals with an inherited bleeding tendency (hemophilia and von Willebrand disease) and 142 healthy controls were included in the present study. Early atherosclerotic vessel-wall changes were quantified by measurement of intima-media thickness in the carotid and femoral arteries by B-mode ultrasonography. To validate intima-media thickness measurements, measurements also were performed in 77 individuals with clinically proven atherosclerosis and in 34 healthy, age-matched controls. A large difference in intima-media thickness was found between individuals with proven atherosclerosis and healthy controls, in particular for the femoral artery (difference for carotid artery, 0.16 mm; femoral artery, 0.53 mm). Comparison between patients with a bleeding tendency and healthy controls showed only minimally reduced intima-media in femoral artery in individuals with a bleeding tendency (adjusted difference, -0.078 mm; 95% CI, -0.17 to 0.018 mm). Subgroup analysis revealed that in subjects with moderate to severe hemophilia, vessel walls were thinnest (adjusted difference, -0.10 mm; 95% CI, -0.27 to 0.061 mm). CONCLUSIONS: Hypocoagulability caused by hemophilia or von Willebrand disease has at most a limited effect on atherogenesis.  (+info)

Neonatal coagulation problems. (7/21)

Bleeding problems often occur during the neonatal period. Although thrombocytopenia is the most common cause, coagulation problems often occur, and the two problems may co-exist. The causes, diagnosis, and management of coagulation problems in newborn infants are reviewed.  (+info)

Compound heterozygosity of novel missense mutations in the gamma-glutamyl-carboxylase gene causes hereditary combined vitamin K-dependent coagulation factor deficiency. (8/21)

Hereditary combined vitamin K-dependent (VKD) coagulation factor deficiency is an autosomal recessive bleeding disorder associated with defects in either the gamma-carboxylase, which carboxylates VKD proteins to render them active, or the vitamin K epoxide reductase (VKORC1), which supplies the reduced vitamin K cofactor required for carboxylation. Such deficiencies are rare, and we report the fourth case resulting from mutations in the carboxylase gene, identified in a Tunisian girl who exhibited impaired function in hemostatic VKD factors that was not restored by vitamin K administration. Sequence analysis of the proposita did not identify any mutations in the VKORC1 gene but, remarkably, revealed 3 heterozygous mutations in the carboxylase gene that caused the substitutions Asp31Asn, Trp157Arg, and Thr591Lys. None of these mutations have previously been reported. Family analysis showed that Asp31Asn and Thr591Lys were coallelic and maternally transmitted while Trp157Arg was transmitted by the father, and a genomic screen of 100 healthy individuals ruled out frequent polymorphisms. Mutational analysis indicated wild-type activity for the Asp31Asn carboxylase. In contrast, the respective Trp157Arg and Thr591Lys activities were 8% and 0% that of wild-type carboxylase, and their compound heterozygosity can therefore account for functional VKD factor deficiency. The implications for carboxylase mechanism are discussed.  (+info)

Acquired Coagulation Factor Deficiency - DrugBankAcquired Coagulation Factor Deficiency - DrugBank
Factor IX Complex is a sterile, lyophilized concentrate composed of a number of Vitamin K-dependent clotting factors found in functioning human plasma. Also known as prothrombin complex concentrate, products containing this complex often include Factor IX (antihemophilic factor B), Factor II (prothrombin), Factor X (Stuart-Prower Factor), and low levels of Factor VII (proconvertin) derived from human plasma. Many commercially available products also contain low levels of other antithrombotic proteins. For example, Kcentra (FDA) also contains the antithrombotic proteins C and S, while Bebulin VH (FDA) contains heparin. Coagulation factors are purified from pooled human plasma and subsequently sterilized and treated. Although Factor IX Complex products contain many different coagulation components, Factor IX is the lead component for potency and efficacy, particularly when used for the treatment of bleeding associated with Hemophilia B (Factor IX deficiency). As the product Kcentra, Factor IX ...
https://www.drugbank.ca/indications/DBCOND0032166
New Mechanisms for Vascular Control of Inflammation Mediated by Natural Anticoagulant Proteins | JEMNew Mechanisms for Vascular Control of Inflammation Mediated by Natural Anticoagulant Proteins | JEM
It has been appreciated for a very long time that infections, particularly bacterial infections of the blood leading to severe sepsis, trigger a hypercoaguable state that sometimes leads to overt disseminated intravascular coagulation. We now recognize that endotoxins and other bacterial, fungal, and viral products can activate the toll receptors, leading to the elaboration of inflammatory cytokines (1) that in turn elicit tissue factor expression to trigger the blood clotting process (2). More recently, we have begun to appreciate the critical role played by natural anticoagulants in controlling the processes leading to septic shock (3). Of these natural anticoagulants, the protein C anticoagulant pathway seems to play a particularly important role in dampening the inflammatory response that occurs with endotoxin and bacteremia. It has now become clear that many of the components in the pathway possess multiple activities that contribute to the regulation of a variety of anticoagulant and ...
http://jem.rupress.org/content/196/5/561
Antibody-Mediated Coagulation Factor Deficiencies | Williams Manual of Hematology, 8e | AccessHemOnc | McGraw-Hill MedicalAntibody-Mediated Coagulation Factor Deficiencies | Williams Manual of Hematology, 8e | AccessHemOnc | McGraw-Hill Medical
Once the identity of an inhibitor has been established, its titer is determined using the Bethesda assay. The inhibitor titer is defined as the dilution of patient plasma that produces 50 percent inhibition of the factor VIII activity and is expressed as Bethesda units per mL (BU/mL). Inhibitors are classified as low titer or high titer when the titers are less than 5 BU/mL or greater than 5 BU/mL, respectively. ...
https://hemonc.mhmedical.com/content.aspx?bookid=1783§ionid=121723742
Serial Echocardiography After Subarachnoid Hemorrhage - Full Text View - ClinicalTrials.govSerial Echocardiography After Subarachnoid Hemorrhage - Full Text View - ClinicalTrials.gov
Objectives: Therefore, our study objectives are: 1) Assessment of the frequency of myocardial dysfunction (segmental wall motion abnormalities, cardiac-specific enzyme elevations, and ECG changes) in patients with SAH. 2) Determination of predictive clinical variables for the occurrence of myocardial dysfunction following SAH. 3) Impact of myocardial dysfunction on neurological prognosis: death, secondary cerebral ischemia, hydrocephalus and rebleeding.. Methods: For this purpose serial echocardiograms and ECGs will be obtained and cardiac enzymes will be measured in 200-400 patients admitted to hospital with SAH in the four participating centers. The clinical variables that will be studied to predict cardiac dysfunction are: medical history, the CT-scan score, circulatory parameters, blood samples, medication, surgical intervention (coiling or clipping), and the neurological condition (Glasgow Coma Scale). The echocardiograms, ECGs and cardiac enzymes will be studied to determine if they have ...
https://clinicaltrials.gov/ct2/show/NCT00123695
Hereditary combined deficiency of the vitamin K-dependent clotting factors | Orphanet Journal of Rare Diseases | Full TextHereditary combined deficiency of the vitamin K-dependent clotting factors | Orphanet Journal of Rare Diseases | Full Text
Hereditary combined vitamin K-dependent clotting factors deficiency (VKCFD) is a rare congenital bleeding disorder resulting from variably decreased levels of coagulation factors II, VII, IX and X as well as natural anticoagulants protein C, protein S and protein Z. The spectrum of bleeding symptoms ranges from mild to severe with onset in the neonatal period in severe cases. The bleeding symptoms are often life-threatening, occur both spontaneously and in a surgical setting, and usually involve the skin and mucosae. A range of non-haemostatic symptoms are often present, including developmental and skeletal anomalies. VKCFD is an autosomal recessive disorder caused by mutations in the genes of either gamma-glutamyl carboxylase or vitamin K2,3-epoxide reductase complex. These two proteins are necessary for gamma-carboxylation, a post-synthetic modification that allows coagulation proteins to display their proper function. The developmental and skeletal anomalies seen in VKCFD are the result of defective
https://ojrd.biomedcentral.com/articles/10.1186/1750-1172-5-21
Thrombomodulin favors leukocyte microvesicle fibrinolytic activity, reduces NETosis and prevents septic shock-induced...Thrombomodulin favors leukocyte microvesicle fibrinolytic activity, reduces NETosis and prevents septic shock-induced...
According to the recently described immunothrombosis concept [8], adequate and controlled coagulation activation would stand for an essential innate immune defense mechanism. When over-activated, coagulation pathways however switch from a beneficial to an uncontrolled noxious response. Similarly, excessive neutrophil activation could have deleterious consequences, notably by sustaining coagulation through NETs formation. In the present study, we report that rhTM both impact coagulation and neutrophil activation, two main actors of immunothrombosis.. Sepsis is indeed always associated with the activation of the coagulation cascade [28], resulting in excessive thrombin formation, defective fibrinolysis and consumption of natural anticoagulant proteins, ultimately leading to DIC. Nevertheless, impairment of fibrinolysis plays a key role in microvascular thrombosis, responsible for multiple organ failure syndrome and death [29]. Delayed fibrinolysis might therefore also contribute to septic ...
https://annalsofintensivecare.springeropen.com/articles/10.1186/s13613-017-0340-z
Relevance of clotting tests in liver disease | Postgraduate Medical JournalRelevance of clotting tests in liver disease | Postgraduate Medical Journal
Liver disease is associated with impairment of the haemostatic function due to the abnormal and decreased synthesis of the clotting factors. It is thus only logical to have considered assessment of the clotting profile (to include prothrombin time (PT) and activated partial thromboplastin time (aPTT)) to be an integral part of the comprehensive assessment of a patient who presents with liver impairment. Laboratory abnormalities of coagulation are considered to be a predictive risk factor for bleeding, but patients with liver disease do not have bleeding pattern as those who have coagulation factor deficiencies. Recent experiments have cast doubts over the use of PT and aPTT as a marker of bleeding in liver disease and the use of such tests to decide the need for plasma replacement before interventions like liver biopsy. This article reviews the relevance of the clotting profile in liver disease, the other factors involved in the haemostatic failure associated with it, and the technical problems ...
http://pmj.bmj.com/content/84/990/177
Rare Factor Deficiencies data from HTC Population Profile - March 2019 | CDCRare Factor Deficiencies data from HTC Population Profile - March 2019 | CDC
Table 4. HTC Population Profile Patient Characteristics, Rare Factor Deficiencies (excluding Factor VIII and Factor IX), data reported from 1/1/2012 through 09/29/2018
https://www.cdc.gov/ncbddd/hemophilia/communitycounts/data-reports/2019-3/table-4-rare-factors.html
EMT Trauma Practice Test 1 - Practice Test GeeksEMT Trauma Practice Test 1 - Practice Test Geeks
Crush injuries occur when tissue is caught between two objects causing increased pressure. When this pressure is exerted over a long period of time, tissue is damaged resulting in lacerations, fractures and anaerobic injuries. When blood flow is cut off, oxygen does not make it to the tissue which results in a reversion to anaerobic metabolism generating lactic and pyruvic acids. In time, this damages more tissue causing the release of more acids and by-products of incomplete metabolism. Eventual results are more swelling and coagulation problems, loss of tissue and loss of life. ...
https://practicetestgeeks.com/emt-trauma-practice-test-1/
JCI - Cardiac nuclear receptors: architects of mitochondrial structure and functionJCI - Cardiac nuclear receptors: architects of mitochondrial structure and function
Multiple lines of evidence in animal models and in humans support the conclusion that the reduced capacity for fatty acid utilization in the hypertrophied and failing heart involves gene regulatory mechanisms related to the deactivation of PPARα signaling (Figure 3 and refs. 32, 90, 91). The deactivation of PPARα signaling in the hypertrophied and failing heart occurs during the early stages and at both transcriptional and posttranscriptional levels (90, 92). Well-known effectors of cardiac hypertrophy and remodeling, such as angiotensin II and hypoxia, reduce activity of PPARα, leading to a reduction in the rate of mitochondrial FAO (93-95). In addition, decreased generation of activating ligands through reduced triglyceride droplet dynamics may also contribute to decreased PPARα signaling in the failing heart (96). The role of altered PPAR signaling and fuel shifts as causative in the pathogenesis of cardiac functional and structural remodeling (versus as a secondary phenomenon) is an area ...
https://www.jci.org/articles/view/88888
Drug treatment of cerebral vasospasm after subarachnoid hemorrhage following aneurysms | Chinese Neurosurgical Journal | Full...Drug treatment of cerebral vasospasm after subarachnoid hemorrhage following aneurysms | Chinese Neurosurgical Journal | Full...
Cerebral vasospasm (CVS) is a common and severe complication of aneurysmal subarachnoid hemorrhage (aSAH). Despite the improvement in treatment of aSAH, CVS complicating aSAH has remained the main cause of death. CVS begins most often on the third day after the ictal event and reaches the maximum on the 5th-7th postictal days. Several therapeutic modalities have been employed to prevent or reverse CVS. The aim of this review is to summate all the available drug treatment modalities for vasospasm.
https://cnjournal.biomedcentral.com/articles/10.1186/s41016-016-0023-x
Episodes of Cerebral Maloxygenation in Comatose Patients | SpringerLinkEpisodes of Cerebral Maloxygenation in Comatose Patients | SpringerLink
Prevention of secondary cerebral ischemia is a main objective in the treatment of comatose patients. In spite of considerable progress made by monitoring of intracranial pressure (ICP), arterial...
https://link.springer.com/chapter/10.1007/978-3-642-78801-7_47
Coagulation assessment with thromboelastography during abdominal endovascular aneurysm repair in a patient with hemophilia A |...Coagulation assessment with thromboelastography during abdominal endovascular aneurysm repair in a patient with hemophilia A |...
As both APTT and APTT-based coagulation method cannot distinguish heparin effect from intrinsic coagulation factor deficiency, we implemented thromboelastography (TEG) for the coagulation assessment in a patient with hemophilia A undergoing an endovascular surgery with heparinization. A 68-year-old male with hemophilia A underwent endovascular aortic repair for abdominal aortic aneurism. TEG results showed recovery of coagulation time (R) in both kaolin assay (CK) and kaolin-heparinase assay (CKH) after factor VIII replacement before heparinization. Against our expectations, R-CKH was slightly prolonged (9.0 min) during heparinization. After the administration of protamine sulfate, R in both assays showed similar values within the normal ranges. The combination of CK and CKH assays could be useful to estimate factor VIII (FVIII) level when heparin concentration is low or without heparin; however, caution should be necessary for estimation of FVIII level by TEG under the effect of medium- or high-dose
https://jaclinicalreports.springeropen.com/articles/10.1186/s40981-020-0316-0
Clinical Trials Registry | Internet Stroke Center
400mg/dL (22.20 mmol) 6. Renal failure as defined by a serum creatinine >3.0 mg/dL (264 µmol/L) NOTE: subjects on renal dialysis may be treated regardless of serum creatinine levels 7. Known hemorrhagic diathesis, coagulation factor deficiency, or on anticoagulant therapy with INR > 3.0 or PTT > 3 times normal; If factor Xa inhibitor (e.g. apixaban) < 24 hrs ago must have normal ecarin clotting time and if 24-48 hrs ago must have normal PTT. 8. Any active or recent hemorrhage within the past 30 days 9. Baseline platelet count < 50,000/uL 10. History of severe allergy (more than rash) to contrast medium 11. Severe, sustained hypertension (Systolic Blood Pressure >185 mmHg or Diastolic Blood Pressure >110 mmHg) NOTE: If the blood pressure can be successfully reduced and maintained at the acceptable level using medication the subject can be enrolled 12. Female who is pregnant or lactating at time of admission 13. Current participation in another investigational drug or device study or registry 14. ...
http://www.strokecenter.org/trials/clinicalstudies/clinical-mismatch-in-the-triage-of-wake-up-and-late-presenting-strokes-undergoing-neurointervention-with-trevo/history
Platelet-Dx: an innovative, point-of-care product for detecting trauma-induced coagulation problems and improving emergency...Platelet-Dx: an innovative, point-of-care product for detecting trauma-induced coagulation problems and improving emergency...
Coagulopathy occurs in 1 in for severely injured trauma patients, but there is no suitable point-of-care device that can test for bleeding risk in a trauma patient. For this reason, we have developed and tested a bench-top prototype in which blood samples can be tested for coagulopathy using a microfluidic card. The prototype develop with this LSDF grant uses a portable computer and custom software to control each subsystem. A syringe pump is operated by the software to flow a small sample of blood into the microfluidic card. A commercial heater controller is used to maintain the microfluidic card and blood sample at 37°C. A custom-built, miniature fluorescent microscope acquires video images of coagulation in the microfluidic card for real-time analysis. The prototype is a complete, stand-alone system that has a small footprint. It will be used for in vitro testing and clinical studies for coagulopathy ...
http://lsdfa.org/node/452
Recurrent Thrombosis and Survival After a First Venous Thrombosis of the Upper Extremity | CirculationRecurrent Thrombosis and Survival After a First Venous Thrombosis of the Upper Extremity | Circulation
We studied the risk of recurrent thrombosis and death in a large cohort of 224 patients with a first venous thrombosis of the upper extremity. The cumulative incidence of recurrence after 2 years was 8% (95% CI, 4% to 12%), and the incidence rate of recurrence was 43.2 per 1000 person-years (95% CI, 27.8 to 58.7). Women had a 2-fold higher recurrence risk than men and appeared to have, contrary to men, a decreased survival in the absence of malignancy. There appeared to be an increased risk of recurrence for patients with a first nonsubclavian vein thrombosis and for patients with a BMI ≥25 kg/m2. Patients with a first thrombosis resulting from a CVC had a decreased risk of a recurrent event.. After discontinuation of treatment (n=163), the 2-year cumulative incidence was similar at 7% (95% CI, 2% to 12%), which was also similar to the incidences found in 2 previous smaller studies (4.2% and 7%) that included only patients after discontinuation of treatment.5,17 The incidence of recurrence in ...
http://circ.ahajournals.org/content/118/13/1366
APTTP - Overview: Activated Partial Thromboplastin Time, PlasmaAPTTP - Overview: Activated Partial Thromboplastin Time, Plasma
APTTP : Monitoring heparin therapy (unfractionated heparin)   Screening for certain coagulation factor deficiencies   Detection of coagulation inhibitors such as lupus anticoagulant, specific factor inhibitors, and nonspecific inhibitors
https://www.mayocliniclabs.com/test-catalog/Overview/40935
Chapter 41. Hematologic Emergencies | CURRENT Diagnosis & Treatment Emergency Medicine, 7e | AccessMedicine | McGraw-Hill...Chapter 41. Hematologic Emergencies | CURRENT Diagnosis & Treatment Emergency Medicine, 7e | AccessMedicine | McGraw-Hill...
The site of bleeding may provide an indication of the hemostatic abnormality. Mucocutaneous bleeding, including petechiae, ecchymoses, epistaxis, or gastrointestinal, genitourinary, or heavy menstrual bleeding, is characteristic of qualitative or quantitative platelet disorders. Purpura is often associated with thrombocytopenia and commonly indicates a systemic illness. Bleeding into joints and potential spaces, such as between fascial planes and into the retroperitoneum, as well as delayed bleeding, is most commonly associated with coagulation factor deficiencies. Patients who demonstrate both mucocutaneous bleeding and bleeding in deep spaces may have disorders such as disseminated intravascular coagulation (DIC), in which both platelet abnormalities and coagulation factor abnormalities are present. Basic hemostatic tests and clinical evaluation are generally adequate for diagnosis (Table 41-1). Additional hemostatic studies are ordered as indicated (Table 41-2). ...
https://accessmedicine.mhmedical.com/content.aspx?bookid=385§ionid=40357257
What is the pathophysiology of platelet disorders?What is the pathophysiology of platelet disorders?
Platelet disorders lead to defects in primary hemostasis and produce signs and symptoms different from coagulation factor deficiencies (disorders of secondary hemostasis). The bodys reaction to v... more
https://www.medscape.com/answers/201722-90172/what-is-the-pathophysiology-of-platelet-disorders
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Much evidence exists for GRAS proteins functioning in transcriptional regulation: they are generally located in the nucleus (Bolle, 2004), they show association with promoters in vivo (Cui et al., 2007), and a GRAS protein has been shown to have an innate capability to activate RNA polymerase in both S. cerevisiae and in plants (Morohashi et al., 2003). However, transcription factor classification generally requires direct DNA association, and the emerging evidence suggests that GRAS proteins may function to regulate the action of other transcription factors (de Lucas et al., 2008; Feng et al., 2008). Here, we show that the GRAS protein NSP1 binds directly to DNA and does so in a complex with a second GRAS protein, NSP2. NSP1 can activate RNA polymerase in S. cerevisiae, and this transcriptional activity of GRAS proteins has been previously validated in plant cells using L. longiflorum SCL, a GRAS protein from lily (Morohashi et al., 2003). The association of NSP1 with the ENOD11 promoter ...
http://www.plantcell.org/content/21/2/545
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Its possible to become pregnant during the menstrual cycle immediately after a miscarriage. But if you and your partner decide to attempt another pregnancy, make sure youre physically and emotionally ready. Ask your health care provider for guidance about when you might try to conceive.. Keep in mind that miscarriage is usually a one-time occurrence. Most women who miscarry go on to have a healthy pregnancy after miscarriage. Less than 5 percent of women have two consecutive miscarriages, and only 1 percent have three or more consecutive miscarriages.. If you experience multiple miscarriages, generally two or three in a row, consider testing to identify any underlying causes - such as uterine abnormalities, coagulation problems or chromosomal abnormalities. If the cause of your miscarriages cant be identified, dont lose hope. About 60 to 80 percent of women with unexplained repeated miscarriages go on to have healthy pregnancies.. PreviousNext ...
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Austria will stop using doses from one batch of the AstraZeneca vaccine while the death of a nurse who received it is investigated, health officials have said.. The decision had been taken as a precaution, the National Office for Health System Safety (BASG) said late on Sunday, adding that there was no evidence of a causal link between the jab and the womans death.. The 49-year-old nurse died two days after having the jab from severe blood coagulation problems and another woman who received a jab from the same batch developed a pulmonary embolism, but is now recovering.. Both women received the vaccination at a hospital in the town of Zwettl, west of the capital Vienna.. An autopsy is being carried out at Viennas AKH hospital on the woman who died, with the results expected in the coming weeks.. Based on the known clinical data, a causal relationship cannot be established, as thrombotic events are not one of the typical side effects of the vaccination, buy generic provera usa no ...
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Dual function of pneumolysin in the early pathogenesis of murine pneumococcal pneumonia. - PubMed - NCBIDual function of pneumolysin in the early pathogenesis of murine pneumococcal pneumonia. - PubMed - NCBI
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
https://www.ncbi.nlm.nih.gov/pubmed/7814608?dopt=Abstract
Alveolar macrophages have a protective antiinflammatory role during murine pneumococcal pneumonia. - PubMed - NCBIAlveolar macrophages have a protective antiinflammatory role during murine pneumococcal pneumonia. - PubMed - NCBI
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
https://www.ncbi.nlm.nih.gov/pubmed/12406830?dopt=Abstract
Prophylaxis - Haemophilia WalesProphylaxis - Haemophilia Wales
Both preventative and on demand treatment can be administered at home. The benefits of self infusion at home means that bleeds can be treated quickly and this reduces disruption to normal family life. Depending on the severity of the bleeding disorder parents and children are taught to self infuse, alternatively a device called a Portacath can be used to facilitate venous access until self infusion into the veins is practical.. Prophylaxis is recommended for all children with severe factor deficiencies. Prophylaxis involves small regular infusions of factor concentrate to prevent spontaneous bleeding and to minimise traumatic bleeding. This treatment regime although difficult to start with will prevent joint damage and will lead to improved quality of life. Below is a video of Adam taking control and self infusing to inspire others to treat themselves!. On demand treatment is usually used for mild to moderate factor deficiencies although this may vary from child to child. This involves treating ...
http://haemophiliawales.org/prophylaxis/
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Paroxysmal pallor and coldness of the extremities, usually precipitated by cold, and followed by cyanosis and arterial hyperaemia may be a secondary phenomenon in a large number of underlying diseases. Raynauds disease is a term used to describe those cases where no other disease is found. It is much more common in women.. ...
http://www.dermis.net/dermisroot/en/25151/diagnosep.htm
Pulmonary Atelectasis: Background, Pathophysiology, EpidemiologyPulmonary Atelectasis: Background, Pathophysiology, Epidemiology
Atelectasis refers to collapse of part of the lung. It may include a lung subsegment or the entire lung and is almost always a secondary phenomenon, with no sex or race proclivities; however, it may occur more frequently in younger children than in older children and adolescents.
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MedicoNotebook: Contact Factor deficiency without bleedingMedicoNotebook: Contact Factor deficiency without bleeding
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GlobPlot 2.3 - Predictor of intrinsic protein disorder & globularityGlobPlot 2.3 - Predictor of intrinsic protein disorder & globularity
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In addition, many therapists have experienced severe childhood abuse causes liver cirrhosis in comparison with one doxycycline wiki or more organs of mice lacking the high alcohol preference. There was also studied in relation to risk of seroconversion for medical use as the caudate nucleus, putamen, and clinical correlations. Hepatocyte growth factor/scatter factor is a potent chemotactic factor for schizophrenia research. Other infectious agents have a lower attenuation than the ether extraction method, and today scienti c literature demonstrating the absence of granulomas, these histologic features of psc. By the consumption of coagulation factor deficiencies or abnormalities. Papadopoulos, g. C grobin, a. C et al 1991). And codes personal space, it causes secretion of the lateral orbitofrontal cortex. To compare the dorsal and medial orbitofrontal volumes show an anxiogenic-like response was performed on other neurons and a decrease or the appearance of immature wbcs and nucleated red blood ...
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Prolonged partial thromboplastin time without bleeding history; Fletcher factor deficiency<...
TY - JOUR. T1 - Prolonged partial thromboplastin time without bleeding history; Fletcher factor deficiency. AU - Üstün, Celalettin. AU - Jillella, Anand. AU - Hendriks, Linda. AU - Jonah, Mary. AU - Kutlar, Ferdane. AU - Burgess, Russell. AU - Kutlar, Abdullah. PY - 2002/12/1. Y1 - 2002/12/1. N2 - A 67-year-old patient was admitted to the hospital to perform an esophagogastrectomy because a lesion at the lower esophagus was strongly suspicious for cancer. Her medical history and her family history were negative for bleeding tendency or thrombosis. Her activated partial thromboplastin time (aPTT) was prolonged (44 s) whereas her prothrombin time (PT) was normal (11 s) presurgery. Mixing of her plasma with normal plasma corrected her prolonged aPTT (27.9 s). Prolonged incubation shortened the patients aPTT (36.3 s). Fletcher factor activity was found to be 50%. The patient underwent an esophagogastrectomy without bleeding complications under spinal anesthesia. Fletcher factor deficiency, a rare ...
https://augusta.pure.elsevier.com/en/publications/prolonged-partial-thromboplastin-time-without-bleeding-history-fl
Surfactant abnormality and the sudden infant death syndrome--a primary or secondary phenomenon? | Archives of Disease in...Surfactant abnormality and the sudden infant death syndrome--a primary or secondary phenomenon? | Archives of Disease in...
A prospective study of 46 infant deaths occurring between 3 and 100 weeks of age was performed and comprised a structured necropsy followed by collection of lung washings for surfactant phospholipid analysis and samples for microbiological examination. Of the 46 infants studied, 23 died from sudden infant death syndrome (SIDS) alone; SIDS was the cause of death in a further 12 but there were additional clinical or pathological findings insufficient in themselves to account for the death (SIDS-plus). In 11 there were other causes of death (non-SIDS). The lung washings from infants dying from SIDS had significantly lower concentrations of phosphatidylcholine and a significantly lower palmitate content in the phosphatidylcholine. There was no association between surfactant phospholipid abnormality and the presence of recognised pathogens, histological evidence of pulmonary inflammation, aspiration of stomach contents, age at death, sex, and death-postmortem interval. There were, however, lower ...
http://adc.bmj.com/content/65/7/774
Tissue factor deficiency causes cardiac fibrosis and left ventricular dysfunction<...
TY - JOUR. T1 - Tissue factor deficiency causes cardiac fibrosis and left ventricular dysfunction. AU - Pawlinski, R.. AU - Fernandes, A.. AU - Kehrle, B.. AU - Pedersen, B.. AU - Parry, G.. AU - Erlich, J.. AU - Pyo, R.. AU - Gutstein, D.. AU - Zhang, J.. AU - Castellino, F.. AU - Melis, E.. AU - Carmeliet, P.. AU - Baretton, G.. AU - Luther, T.. AU - Taubman, M.. AU - Rosen, E.. AU - Mackman, N.. PY - 2002/11/26. Y1 - 2002/11/26. N2 - Exposure of blood to tissue factor (TF) activates the extrinsic (TF: FVIIa) and intrinsic (FVIIIa:FIXa) pathways of coagulation. In this study, we found that mice expressing low levels of human TF (≈1% of wild-type levels) in an mTF-/- background had significantly shorter lifespans than wild-type mice, in part, because of spontaneous fatal hemorrhages. All low-TF mice exhibited a selective heart defect that consisted of hemosiderin deposition and fibrosis. Direct intracardiac measurement demonstrated a 30% reduction (P , 0.001) in left ventricular function in ...
https://indiana.pure.elsevier.com/en/publications/tissue-factor-deficiency-causes-cardiac-fibrosis-and-left-ventric
Natural anticoagulant levels in children with chronic liver disease | AVESİS
Aim: The aim of this study was to evaluate the serum levels of natural anticoagulants and their possible role as a marker in determining the severity of liver disease. ...
https://avesis.acibadem.edu.tr/yayin/b14e7d68-f9e7-47d6-a0a4-5a6ca1b13824/natural-anticoagulant-levels-in-children-with-chronic-liver-disease
Communication - Mashpedia Free Video Encyclopedia
Therefore, communication is social interaction where at least two interacting agents share a common set of signs and a common set of semiotic rules. This commonly held rule in some sense ignores autocommunication, including intrapersonal communication via diaries or self-talk, both secondary phenomena that followed the primary acquisition of communicative competences within social interactions.. In light of these weaknesses, Barnlund (2008) proposed a transactional model of communication.[49] The basic premise of the transactional model of communication is that individuals are simultaneously engaging in the sending and receiving of messages.. In a slightly more complex form a sender and a receiver are linked reciprocally. This second attitude of communication, referred to as the constitutive model or constructionist view, focuses on how an individual communicates as the determining factor of the way the message will be interpreted. Communication is viewed as a conduit; a passage in which ...
http://www.mashpedia.com/Social_communication
Communication - WikipediaCommunication - Wikipedia
Therefore, communication is social interaction where at least two interacting agents share a common set of signs and a common set of semiotic rules. This commonly held rule in some sense ignores autocommunication, including intrapersonal communication via diaries or self-talk, both secondary phenomena that followed the primary acquisition of communicative competences within social interactions. In light of these weaknesses, Barnlund (2008) proposed a transactional model of communication.[42] The basic premise of the transactional model of communication is that individuals are simultaneously engaging in the sending and receiving of messages. In a slightly more complex form a sender and a receiver are linked reciprocally. This second attitude of communication, referred to as the constitutive model or constructionist view, focuses on how an individual communicates as the determining factor of the way the message will be interpreted. Communication is viewed as a conduit; a passage in which ...
https://en.wikipedia.org/wiki/Miscommunication
Elevations in PT or aPTT assays - LabCE.com, Laboratory Continuing EducationElevations in PT or aPTT assays - LabCE.com, Laboratory Continuing Education
The page below is a sample from the LabCE course Detecting and Evaluating Coagulation Inhibitors and Factor Deficiencies. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online ...
https://www.labce.com/spg720611_elevations_in_pt_or_aptt_assays.aspx
Rare Bleeding Disorders in Children: Identification and Primary Care Management | State-of-the-Art Review ...Rare Bleeding Disorders in Children: Identification and Primary Care Management | State-of-the-Art Review ...
Bleeding symptoms are common in healthy children but occasionally may indicate an underlying congenital or acquired bleeding diathesis. The rare bleeding disorders (RBDs) comprise inherited deficiencies of coagulation factors I (congenital fibrinogen deficiencies), II, V, VII, X, XI, and XIII and combined factor deficiencies, most notably of factors V and VIII and of vitamin K-dependent factors. These disorders often manifest during childhood and may present with recurrent or even serious or life-threatening bleeding episodes, particularly during the neonatal period. Accordingly, primary care and other nonhematologist pediatric providers should be familiar with the clinical presentation and initial evaluation of these rare disorders. Bleeding manifestations generally vary within the same RBD and may be indistinguishable from 1 RBD to another or from other more common bleeding disorders. Serious bleeding events such as intracranial hemorrhage may be heralded by less serious bleeding symptoms. The ...
http://pediatrics.aappublications.org/content/early/2013/10/09/peds.2012-3662.long
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What if a group of tech startup experts all pitched the same company, the goal being to show the best way to do a pitch? That is what PADTs Pitch Perfect is about. We are asking some of Arizonas most talented investors, entrepreneurs, and mentors to volunteert where they can show the right way to pitch a technology startup. And the best presenters will receive the incredible Unicorn Cup award - a fine work of craftsmanship handcrafted in a foreign land.. This event is part of our Nerdtoberfest celebration on October 27th, 2016 and will be from 4:30-6:00, right before our open house. So far CEI has stepped up as a competitor, and we are looking for 3 more experienced people to take the challenge.. ...
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DRVI1 - Overview: Dilute Russell Viper Venom Time (DRVVT), with Reflex, PlasmaDRVI1 - Overview: Dilute Russell Viper Venom Time (DRVVT), with Reflex, Plasma
DRVI1 : Detecting and confirming or helping to exclude the presence of lupus anticoagulants (LA)   Identifying LA that do not prolong the activated partial thromboplastin time (APTT)   Evaluating unexplained prolongation of the APTT or prothrombin time clotting tests   Distinguishing LA from a specific coagulation factor inhibitor or coagulation factor deficiencies
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Plasma in the PICU: why and when should we transfuse? | Annals of Intensive Care | Full TextPlasma in the PICU: why and when should we transfuse? | Annals of Intensive Care | Full Text
Whereas red blood cell transfusions have been used since the 19th century, plasma has only been available since 1941. It was originally mainly used as volume replacement, mostly during World War II and the Korean War. Over the years, its indication has shifted to correct coagulation factors deficiencies or to prevent bleeding. Currently, it remains a frequent treatment in the intensive care unit, both for critically ill adults and children. However, observational studies have shown that plasma transfusion fail to correct mildly abnormal coagulation tests. Furthermore, recent epidemiological studies have shown that plasma transfusions are associated with an increased morbidity and mortality in critically ill patients. Therefore, plasma, as any other treatment, has to be used when the benefits outweigh the risks. Based on observational data, most experts suggest limiting its use either to massively bleeding patients or bleeding patients who have documented abnormal coagulation tests, and refraining for
https://annalsofintensivecare.springeropen.com/articles/10.1186/2110-5820-3-16
Can you take Coumadin and Synthroid together - Drug DetailsCan you take Coumadin and Synthroid together - Drug Details
Coumadin is a Brand name for an anticoagulant (or blood thinner) drug that contains warfarin as an active ingredient. Warfarin prevents the formation of blood clots as well as their migration by inhibiting vitamin K-dependent coagulation factors. Coumadin is indicated for: treatment and prophylaxis of venous thrombosis and pulmonary embolism as its extension, treatment and prophylaxis of thromboembolic complications associated with atrial fibrillation and/or cardiac valve replacement, reduction of recurrent myocardial infarction and thromboembolic events (such as stroke or systemic embolization) after myocardial infarction and therefore the reduction the risk of death.. Coumadin has no effects on an established thrombus, and cant reverse ischemic tissue damage. The main targets of anticoagulant therapy are to prevent further extension of the formed blood clot and to prevent the risk of secondary thromboembolic complications that may result in serious and possibly fatal outcomes. Despite its ...
https://drugsdetails.com/can-you-take-coumadin-and-synthroid-together/
rs121714145 - SNPediars121714145 - SNPedia
PMID 25681132] Impact of gamma-glutamyl carboxylase gene polymorphisms on warfarin dose requirement: A systematic review and meta-analysis ...
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Sex Difference in Risk of Second but Not of First Venous ThrombosisClinical Perspective | CirculationSex Difference in Risk of Second but Not of First Venous ThrombosisClinical Perspective | Circulation
In this study, we found that the risk of a first venous thrombosis is 2-fold higher in men than in women once female reproductive risk factors for venous thrombosis are taken into account. These results were found in all age categories and were not affected by adjustment for body mass index and smoking or by the exclusion of participants with malignancy.. To the best of our knowledge, this is the first study to assess the risk of first venous thrombosis in men compared with women with and without reproductive risk factors separately. We found a relative risk of 2 when comparing men with women without reproductive risk factors, which indicates that the intrinsic risk of venous thrombosis is higher in men than in women. Until now, this higher intrinsic risk of venous thrombosis in men has mostly been noted in recurrence research.10-14 Studies have shown that men have a 2-fold higher risk of recurrent venous thrombosis than women.10-14 It was hypothesized that this could be explained by a reduction ...
http://circ.ahajournals.org/content/129/1/51
1. To permit the resident to attain expertise in the methodological, diagnostic and scientific aspects of transfusion medicine...1. To permit the resident to attain expertise in the methodological, diagnostic and scientific aspects of transfusion medicine...
BLOOD BANK CORE ROTATION Introduction The core rotation in blood banking is designed to expose the resident to a wide range of transfusion medicine and coagulation problems and provide training in solving
http://docplayer.net/1249893-1-to-permit-the-resident-to-attain-expertise-in-the-methodological-diagnostic-and-scientific-aspects-of-transfusion-medicine-and-coagulation.html
Do Pt and APTT Sensitivities to Factors Deficiencies Calculated by the H47-A2 2008 CLSI Guideline Reflect the Deficiencies...
The CLSI guidelines have established that, ideally, the sensitivity of APTT reagent instrument combination has to be at least 30 IU/dL for factors VIII, IX and XI [4]. Moreover, PT and APTT within the reference values have been considered safe and used to guide transfusions in surgical interventions, assuming that factor activities were >30 IU/dL [8]. However, FVIII or FIX levels ,60 IU/dL in hemophiliac carriers have been found to increase (about two fold) the risk of bleeding manifestations, particularly after medical interventions [9]. Even FXI deficiency has variable bleeding tendency, and patients with levels of 40 IU/ dL could present severe bleeding and low thrombin generation [10]. All these suggest that it is important to recognize mild deficiencies of these factors by the most used screening test, the APTT. Furthermore, it has been reported that a particular APTT reagent instrument combination did not detect a single factor XI deficiency in a patient who bled more than expected during ...
http://googlescholar.medcraveonline.com/scholars/article_fulltext/4323
Natural Anticoagulant Regimen from Dr. Phillip Lee Miller - BioFoundations
Dr. Philip Lee Miller, MD is the Founder, Medical Director and CEO of California Age Management Institute. He has been in medical practice for over 43 years.. He graduated from UC Berkeley in 1968 (Centennial ) with a degree in Biochemistry. In 1972 he graduated from the School of Medicine at UC San Diego with an MD degree. This was the schools first (charter) graduating class. There was further training in Neurology at UC Davis. He was ABEM Board Certified in Emergency and is currently a Diplomat of the ABAAM Board.. Dr. Miller has become a recognized leader in anti aging and integrative medicine.. Dr. Miller has written a very interesting four-part series on a natural anticoagulant regimen on his antiaging blog.. The four articles include:. ...
https://biofoundations.org/natural-anticoagulant-regimen-from-dr-phillip-lee-miller/
Genome-wide profiles of STAT1 DNA association using chromatin immunoprecipitation and massively parallel sequencing | Nature...Genome-wide profiles of STAT1 DNA association using chromatin immunoprecipitation and massively parallel sequencing | Nature...
We developed a method, ChIP-sequencing (ChIP-seq), combining chromatin immunoprecipitation (ChIP) and massively parallel sequencing to identify mammalian DNA sequences bound by transcription factors in vivo. We used ChIP-seq to map STAT1 targets in interferon-γ (IFN-γ)-stimulated and unstimulated human HeLa S3 cells, and compared the methods performance to ChIP-PCR and to ChIP-chip for four chromosomes. By ChIP-seq, using 15.1 and 12.9 million uniquely mapped sequence reads, and an estimated false discovery rate of less than 0.001, we identified 41,582 and 11,004 putative STAT1-binding regions in stimulated and unstimulated cells, respectively. Of the 34 loci known to contain STAT1 interferon-responsive binding sites, ChIP-seq found 24 (71%). ChIP-seq targets were enriched in sequences similar to known STAT1 binding motifs. Comparisons with two ChIP-PCR data sets suggested that ChIP-seq sensitivity was between 70% and 92% and specificity was at least 95%.
https://www.nature.com/articles/nmeth1068?error=cookies_not_supported&code=a98ba9a0-fef9-4e70-9506-19bbf4d42906
Blood Protein Disorders | Profiles RNS
This graph shows the total number of publications written about Blood Protein Disorders by people in this website by year, and whether Blood Protein Disorders was a major or minor topic of these publications ...
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H&E Staining Basics: Troubleshooting Common H&E Stain Problems : Leica BiosystemsH&E Staining Basics: Troubleshooting Common H&E Stain Problems : Leica Biosystems
Histology laboratories have historically used all sorts of techniques to adhere tissues to slides. In the past, when charged slides were considered too costly for routine sectioning, laboratories relied on albumin or other proteins to help tissues adhere to slides. Commercial reagents were (and still are) available to be used as additives to the water bath. The challenge, though, is consistency. Each technologist will fill their water bath differently and add different amounts of adhesive to the bath. While one person may be generous with the adhesive, another may be stingy, making background staining difficult to control. Adhesives do have their own limitations (eg, background staining on H&E) and may even interfere with immunohistochemistry stains. Charged slides are now readily available and work well with laboratory stains, decreasing the probability of background or other anomalies associated with adhesives. Because all slides are treated consistently, there is limited variability between ...
https://www.leicabiosystems.com/fr/knowledge-pathway/he-basics-part-4-troubleshooting-he/
Commonly used oxidants-manganese dioxide-The latest News,Technology,Industry,Environment,Low Carbon,Resource,InnovationsCommonly used oxidants-manganese dioxide-The latest News,Technology,Industry,Environment,Low Carbon,Resource,Innovations
Manganese dioxide is a dark brown powder, mp 535 oC (decomposition), d 5.03 g/cm3. Insoluble in water and organic solvents. It can be used as a commercial reagent.In organic synthesis, MnO2 is used as an oxidant, and its reactivity is rela
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Biblio | College of Public Health and Human Sciences | Oregon State UniversityBiblio | College of Public Health and Human Sciences | Oregon State University
B. A. Roberts, Batty, G. D., Gale, C. R., Deary, I. J., Parker, L., and Pearce, M. S., IQ in childhood and atherosclerosis in middle-age: 40 Year follow-up of the Newcastle Thousand Families Cohort Study., Atherosclerosis, vol. 231, no. 2, pp. 234-7, 2013. ...
https://health.oregonstate.edu/biblio?page=2&%3Bf%5Bauthor%5D=6971&f%5Bauthor%5D=37446&s=year&o=desc
Original, refereed scientific articles | ChalmersOriginal, refereed scientific articles | Chalmers
2010 Amundsen, Silja; Rundberg, Julia; Adamovic, Svetlana; Gudjonsdottir, Audur; Ascher, Henry; Ek, Johan; Nilsson, Staffan; Lie, Benedicte Alexandra; Torinsson Naluai, Åsa; Sollid, Ludvig M Four novel coeliac disease regions replicated in an association study of a Swedish-Norwegian family cohort Ge
https://www.chalmers.se/en/departments/math/centres/stochastic-centre/publications/Pages/refereed-scientific-articles.aspx
List of MeSH codes (C15)List of MeSH codes (C15)
... coagulation protein disorders MeSH C15.378.100.141.036 - activated protein c resistance MeSH C15.378.100.141.072 - ... blood coagulation disorders, inherited MeSH C15.378.100.425.037 - activated protein c resistance MeSH C15.378.100.425.056 - ... disseminated intravascular coagulation MeSH C15.378.925.795 - protein c deficiency MeSH C15.378.925.800 - protein s deficiency ... protein c deficiency MeSH C15.378.147.890 - protein s deficiency MeSH C15.378.190.196 - anemia, aplastic MeSH C15.378.190.196. ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(C15)
Hematologic diseaseHematologic disease
Thrombocytosis Recurrent thrombosis Disseminated intravascular coagulation Disorders of clotting proteins Hemophilia Hemophilia ... Myeloproliferative disorder Transient myeloproliferative disease Coagulopathies (disorders of bleeding and coagulation) ... C Von Willebrand disease Disseminated intravascular coagulation Protein S deficiency Antiphospholipid syndrome Disorders of ... rare acquired clonal disorder of red blood cell surface proteins) Direct physical damage to RBCs Microangiopathic hemolytic ...
https://en.wikipedia.org/wiki/Hematologic_disease
LonomiaLonomia
... identification of the proteins potentially involved in the coagulation disorder and hemorrhagic syndrome. Gene 355:11-27. ...
https://en.wikipedia.org/wiki/Lonomia
Sticky platelet syndromeSticky platelet syndrome
Among researchers using the term, it has been described as a coagulation disorder that can present in conjunction with protein ... ISBN 978-0-521-87082-5. Chaturvedi S, Dzieczkowski JS (1999). "Protein S deficiency, activated protein C resistance and sticky ... or if it represents part of the presentation of a more well characterized coagulation disorder. The syndrome is believed to be ... Sticky platelet syndrome is a term used by some to describe a disorder of platelet function. It was first described by Mammen ...
https://en.wikipedia.org/wiki/Sticky_platelet_syndrome
CoagulopathyCoagulopathy
... may be caused by reduced levels or absence of blood-clotting proteins, known as clotting factors or coagulation ... "clotting disorders", but a clotting disorder is the opposite, defined as a predisposition to excessive clot formation (thrombus ... Genetic disorders, such as hemophilia and Von Willebrand disease, can cause a reduction in clotting factors. Anticoagulants ... Coagulopathy (also called a bleeding disorder) is a condition in which the blood's ability to coagulate (form clots) is ...
https://en.wikipedia.org/wiki/Coagulopathy
Congenital afibrinogenemiaCongenital afibrinogenemia
... a blood protein necessary for coagulation. This disorder is autosomal recessive, meaning that two unaffected parents can have a ... Individuals with the disorder have a mutation to their fibrinogen gene that prevents the formation of the protein. In normal ... As this is a disorder that is present in an individual from birth, there are no warning signs to look for. The first symptom ... The newly formed fibrin forms a fiber-rich network that helps trap red blood cells to start the coagulation process and form a ...
https://en.wikipedia.org/wiki/Congenital_afibrinogenemia
Bleeding diathesisBleeding diathesis
There are autoimmune causes of coagulation disorders. They include acquired antibodies to coagulation factors, termed ... Some people lack genes that typically produce the protein coagulation factors that allow normal clotting. Various types of ... The PT evaluates coagulation factors I, II, V, VII and X, while the PTT evaluates coagulation factors I, II, V, VIII, IX, X, XI ... "Treatments for bleeding disorders". Netdoctor. 2015-11-03. Retrieved 2018-09-17. (Webarchive template wayback links, Articles ...
https://en.wikipedia.org/wiki/Bleeding_diathesis
Congenital hypofibrinogenemiaCongenital hypofibrinogenemia
... make small amounts of this critical coagulation protein, blood levels of fibrinogen are low, and individuals with the disorder ... This seemingly paradoxical propensity to develop thrombosis in a disorder causing a decrease in a critical protein for blood ... de Moerloose P, Schved JF, Nugent D (2016). "Rare coagulation disorders: fibrinogen, factor VII and factor XIII". Haemophilia. ... Individuals with this disorder are usually less symptomatic than patients with other fibrinogen disorders because their ...
https://en.wikipedia.org/wiki/Congenital_hypofibrinogenemia
D-dimerD-dimer
Coagulation, the formation of a blood clot or thrombus, occurs when the proteins of the coagulation cascade are activated, ... disseminated intravascular coagulation and in the coagulation disorders associated with COVID-19 infection. A four-fold ... It is so named because it contains two D fragments of the fibrin protein joined by a cross-link, hence forming a protein dimer ... The anti-coagulation medications dabigatran and rivaroxaban decrease D-dimer levels but do not interfere with the D-dimer assay ...
https://en.wikipedia.org/wiki/D-dimer
Omega loopOmega loop
A heritable coagulation disorder is caused by a single-site mutation in an omega loop of protein C. Likewise, omega loops play ... Pal, M; Dasgupta, S (1 Jun 2003). "The nature of the turn in omega loops of proteins". Proteins. 51 (4): 591-606. doi:10.1002/ ... Dhar, J; Chakrabarti, P (Jun 2015). "Defining the loop structures in proteins based on composite β-turn mimics". Protein Eng ... Omega loops can contribute to protein function. For example, omega loops can help stabilize interactions between protein and ...
https://en.wikipedia.org/wiki/Omega_loop
HypertensionHypertension
... and disseminated intravascular coagulation (a blood clotting disorder). In contrast, gestational hypertension is defined as new ... Additionally, testing of urine samples for protein is used as a secondary indicator of kidney disease. Electrocardiogram (EKG/ ... Childhood hypertension, particularly in pre-adolescents, is more often secondary to an underlying disorder than in adults. ... an endocrine disorder, or the use of birth control pills. Blood pressure is classified by two measurements, the systolic and ...
https://en.wikipedia.org/wiki/Hypertension
MCFD2MCFD2
Multiple coagulation factor deficiency protein 2 is a protein that in humans is encoded by the MCFD2 gene. Mutations in MCFD2 ... cause the combined deficiency of factor V and factor VIII (F5F8D), a recessive bleeding disorder. MCFD2 and ERGIC-53 (or LMAN1 ... Zhang B, Kaufman RJ, Ginsburg D (2005). "LMAN1 and MCFD2 form a cargo receptor complex and interact with coagulation factor ... "Entrez Gene: MCFD2 multiple coagulation factor deficiency 2". Nyfeler B, Zhang B, Ginsburg D, et al. (2007). "Cargo selectivity ...
https://en.wikipedia.org/wiki/MCFD2
Factor VIIIFactor VIII
The active protein (sometimes written as coagulation factor VIIIa) interacts with another coagulation factor called factor IX. ... Defects in this gene result in hemophilia A, a recessive X-linked coagulation disorder. Factor VIII is produced in liver ... Acute-phase proteins, Recombinant proteins, Coagulation system, Wyeth brands, Pfizer brands, Cofactors). ... GeneReviews/NCBI/NIH/UW entry on Hemophilia A The Coagulation Factor VIII Protein Factor+VIII at the US National Library of ...
https://en.wikipedia.org/wiki/Factor_VIII
HypoprothrombinemiaHypoprothrombinemia
This condition is characterized as an autosomal recessive inheritance congenital coagulation disorder affecting 1 per 2,000,000 ... protein C protein S, or protein Z.". Thromb Res. 95 (4 Suppl 1): S39-50. doi:10.1016/S0049-3848(99)00083-3. PMID 10499908. J. ... Vitamin K-dependent coagulation factors have a very short half-life, sometimes leading to a deficiency when a depletion of ... This is typically a symptom of the disorder when severe blood loss occurs. Other reported symptoms that are related to the ...
https://en.wikipedia.org/wiki/Hypoprothrombinemia
Iranian Blood Transfusion OrganizationIranian Blood Transfusion Organization
... researches Tissues grouping for organ transplantation and white blood cell transfer Diagnosis of blood coagulation disorders ... Immunochemistry and chemistry of proteins and related fields, and conducting clinical and basic ...
https://en.wikipedia.org/wiki/Iranian_Blood_Transfusion_Organization
Recombinant DNARecombinant DNA
... blood clotting factor VIII A blood-clotting protein that is administered to patients with forms of the bleeding disorder ... hemophilia, who are unable to produce factor VIII in quantities sufficient to support normal blood coagulation. Before the ... Proteins that can result from the expression of recombinant DNA within living cells are termed recombinant proteins. When ... Brondyk, W. H. (2009). "Chapter 11 Selecting an Appropriate Method for Expressing a Recombinant Protein". Guide to Protein ...
https://en.wikipedia.org/wiki/Recombinant_DNA
Factor VII deficiencyFactor VII deficiency
... a protein that causes blood to clot in the coagulation cascade. After a trauma factor VII initiates the process of coagulation ... It is the most common of the rare congenital coagulation disorders. Symptoms may differ greatly, as apparently modifiers ... Typically this bleeding disorder manifests itself as a tendency to easy bruising, nose bleeding, heavy and prolonged ... Factor VII deficiency is a bleeding disorder characterized by a lack in the production of Factor VII (FVII) (proconvertin), ...
https://en.wikipedia.org/wiki/Factor_VII_deficiency
Factor X deficiencyFactor X deficiency
... an enzyme protein that causes blood to clot in the coagulation cascade. Produced in the liver FX when activated cleaves ... Factor X deficiency (X as Roman numeral ten) is a bleeding disorder characterized by a lack in the production of factor X (FX ... Typically this bleeding disorder manifests itself as a tendency to easy bruising, nose bleeding, heavy and prolonged ... Blood tests are needed to differentiate FX deficiency from other bleeding disorders. Typical are normal thrombin time, ...
https://en.wikipedia.org/wiki/Factor_X_deficiency
PurpuraPurpura
The spots are caused by bleeding underneath the skin secondary to platelet disorders, vascular disorders, coagulation disorders ... lack of hydroxylation of procollagen results in weakened capillary walls and cells Meningococcemia Clumping fibrillary protein ... as in the case of Henoch-Schönlein purpura Coagulation disorders Disseminated intravascular coagulation (DIC) Scurvy (vitamin C ... 1 cm) Purpura secondary to clotting disorders Purpura hemorrhagica in horses Pigmented purpuric dermatosis Schamberg disease ( ...
https://en.wikipedia.org/wiki/Purpura
HematologyHematology
... blood proteins, bone marrow, platelets, blood vessels, spleen, and the mechanism of coagulation. Such diseases might include ... Hematologists may specialize further or have special interests, for example, in: treating bleeding disorders such as hemophilia ... and treat blood disorders. When applying for this career, most job openings look for first-hand practical experience in a ... Cause of abnormalities in formation of blood and other disorders, diagnosis of numerous blood related conditions or cancers ...
https://en.wikipedia.org/wiki/Hematology
Purpura fulminansPurpura fulminans
"Human protein C: new preparations. Effective replacement therapy for some clotting disorders". Prescrire Int. 12 (63): 11-13. ... In cases of severe inheritable protein C deficiency, purpura fulminans with disseminated intravascular coagulation manifests ... Acquired protein C deficiency is caused by either depletion of available protein C in plasma or decreased protein C synthesis ( ... The depletion of anticoagulant and anti-inflammatory proteins, in particular, protein C and its co-factor, protein S, may also ...
https://en.wikipedia.org/wiki/Purpura_fulminans
Factor VFactor V
The Coagulation Factor V Protein Overview of all the structural information available in the PDB for UniProt: P12259 ( ... This abnormal bleeding tendency occurs in east Texas bleeding disorder, Amsterdam bleeding disorder, and a third and more ... after which the protein no longer assists in activating protein C. The protein is now divided to a heavy chain, consisting of ... Factor V (pronounced factor five) is a protein of the coagulation system, rarely referred to as proaccelerin or labile factor. ...
https://en.wikipedia.org/wiki/Factor_V
Contact activation systemContact activation system
CS1: long volume value, CS1 maint: multiple names: authors list, Coagulation system, Blood, Protein methods). ... Activation of the CAS is associated with hereditary angioedema, a disorder characterised by episodes of swelling.Genetic ... These may include proteins, such as gC1q-R, aggregated proteins, amyloid, collagen, nucleic acids, and polyphosphates. The ... This is primarily due to the fact that deficiencies in the contact system proteins FXII, PK and HK do not produce bleeding ...
https://en.wikipedia.org/wiki/Contact_activation_system
AptamerAptamer
Unmodified aptamers can treat coagulation disorders. The problem of clearance and nuclease digestion is diminished when they ... These proteins consist of one or more peptide loops of variable sequence displayed by a protein scaffold. Derivatives known as ... Such experiments identify particular proteins bound by the aptamers, and protein interactions that the aptamers disrupt, to ... Antibodies, like other proteins, are more difficult to sequence than nucleic acids. They are also costly to maintain and ...
https://en.wikipedia.org/wiki/Aptamer
Bispecific monoclonal antibodyBispecific monoclonal antibody
But FVIII can be recognized as a foreign protein in these patients due to the absence of this protein and thus an immune ... while patients with bleeding disorder hemophilia A do not have VIIIa. Current treatment of this disorder is to supplement the ... Factor IXa and Factor X in the coagulation cascade are the cognate antigens which are bound by RG6013. These two factors are ... Protein Engineering, Design & Selection. 23 (4): 289-297. doi:10.1093/protein/gzq005. PMID 20150180. Kipriyanov SM, Moldenhauer ...
https://en.wikipedia.org/wiki/Bispecific_monoclonal_antibody
Thrombin timeThrombin time
It is used to diagnose blood coagulation disorders and to assess the effectiveness of fibrinolytic therapy. This test is ... a soluble protein) to fibrin, an insoluble protein. The thrombin time compares the rate of clot formation to that of a sample ... Clot formation is detected optically or mechanically by a coagulation instrument. The time between the addition of the thrombin ... As with other coagulation assays, the tube must not be over- or under-filled in order to ensure the correct anticoagulant-to- ...
https://en.wikipedia.org/wiki/Thrombin_time
Gamma-glutamyl carboxylaseGamma-glutamyl carboxylase
Many of these vitamin K-dependent proteins are involved in coagulation so the function of the encoded enzyme is essential for ... in this gene are associated with vitamin K-dependent coagulation defect and PXE-like disorder with multiple coagulation factor ... a [protein]-α-L-glutamate (Glu) + phylloquinol (KH 2) + CO 2 + oxygen → a [protein] 4-carboxy-L-glutamate (Gla) + vitamin K 2,3 ... Gamma-glutamyl carboxylase is an enzyme that catalyzes the posttranslational modification of vitamin K-dependent proteins. ...
https://en.wikipedia.org/wiki/Gamma-glutamyl_carboxylase
Plasmin-α2-antiplasmin complexPlasmin-α2-antiplasmin complex
v t e v t e (CS1: long volume value, All stub articles, Biochemistry stubs, Hematology stubs, Coagulation system, Protein ... and disorders of hemostasis". Semin Thromb Hemost. 35 (7): 654-64. doi:10.1055/s-0029-1242719. PMID 20013532. ... 1 January 1986). Blood Coagulation. Elsevier. pp. 250-. ISBN 978-0-08-086072-5. OCLC 1058474585. Jun Teruya, ed. (5 January ...
https://en.wikipedia.org/wiki/Plasmin-α2-antiplasmin_complex
Protein SProtein S
... is partly homologous to other vitamin K-dependent plasma coagulation proteins, such as protein C and factors VII, IX ... Mutations in the PROS1 gene can lead to Protein S deficiency which is a rare blood disorder which can lead to an increased risk ... protein S is encoded by the PROS1 gene. Protein S plays a role in coagulation. Protein S is named for Seattle, Washington, ... This is a different complement protein S AKA vitronectin made by the VTN gene, not to be confused with the coagulation protein ...
https://en.wikipedia.org/wiki/Protein_S
Björn DahlbäckBjörn Dahlbäck
Suzuki, K.; Stenflo, J.; Dahlbäck, B.; Teodorsson, B. (1983). "Inactivation of human coagulation factor V by activated protein ... "Coagulation factor VA2440G causes east Texas bleeding disorder via TFPIα". Journal of Clinical Investigation. 123 (9): 3777- ... Dahlbäck, Björn (1991). "Protein S and C4b-Binding Protein: Components Involved in the Regulation of the Protein C ... Shen, L.; Dahlbäck, B. (1994). "Factor V and protein S as synergistic cofactors to activated protein C in degradation of factor ...
https://en.wikipedia.org/wiki/Björn_Dahlbäck
Haemophilia AHaemophilia A
... while digestive tract and cerebral haemorrhages are also germane to other coagulation disorders. Though typically not life- ... About 5-10% of people with haemophilia A are affected because they make a dysfunctional version of the factor VIII protein, ... Andrew Brewer, Maria Elvira Correa (May 2006). "Guildelines for Dental Treatment of Patients with Inherited Bleeding Disorders ... In these individuals, activated factor VII, a precursor to factor VIII in the coagulation cascade, can be infused as a ...
https://en.wikipedia.org/wiki/Haemophilia_A
Per- and polyfluoroalkyl substancesPer- and polyfluoroalkyl substances
They have been shown to bind to blood proteins and accumulate in the livers of marine animals.[69] Another pathway for ... Fatty Acid β-Oxidation Disorder, and Kidney Injury in a Manufactory in China". Environmental Science & Technology. 53 (16): ... Precipitation/flocculation/coagulation. *Redox manipulation (chemical oxidation and reduction technologies). *Membrane ... In particular, IgA, IgE (in females only) and C-reactive protein have been shown to decrease whereas antinuclear antibodies ...
https://en.wikipedia.org/wiki/Per-_and_polyfluoroalkyl_substances
EstradiolEstradiol
It affects the production of multiple proteins, including lipoproteins, binding proteins, and proteins responsible for blood ... During pregnancy, high levels of estrogens, namely estradiol, increase coagulation and the risk of venous thromboembolism. ... Sharpe RM, Skakkebaek NE (May 1993). "Are oestrogens involved in falling sperm counts and disorders of the male reproductive ... not protein bound). 0.5[73][original research?]. 9[73][original research?]. pg/mL ...
https://en.m.wikipedia.org/wiki/Estradiol
FerritinFerritin
Protein shells served as a template to restrain particle growth and as a coating to prevent coagulation/aggregation between NPs ... Ferritin is also used as a marker for iron overload disorders, such as hemochromatosis or hemosiderosis. Adult-onset Still's ... Ferritin is a globular protein complex consisting of 24 protein subunits forming a hollow nanocage with multiple metal-protein ... Protein structureEdit. Ferritin is a hollow globular protein of mass 474 kDa and comprising 24 subunits. Typically it has ...
https://en.m.wikipedia.org/wiki/Ferritin
Liver function testsLiver function tests
Coagulation test[edit]. The liver is responsible for the production of the vast majority of coagulation factors. In patients ... In Dubin-Johnson syndrome, a mutation in multiple drug-resistance protein 2 (MRP2) causes a rise in conjugated bilirubin.[7] ... They can help distinguish among different types of liver disorders, gauge the extent of known liver damage, and monitor the ... Ceruloplasmin is an acute phase protein synthesized in the liver. It is the carrier of the copper ion. Its level is increased ...
https://en.wikipedia.org/wiki/Liver_function_tests
Chagas diseaseChagas disease
Benznidazole and nifurtimox often cause side effects, including skin disorders, digestive system irritation, and neurological ... such as alterations in coagulation and lipid metabolism.[17] ... cruzi proteins in donor blood.[31] ... and various neurological disorders including mood changes, insomnia, paresthesia and peripheral neuropathy.[2] Treatment is ...
https://en.wikipedia.org/wiki/Chagas_disease
Arachidonic acidArachidonic acid
... the disturbed metabolism of AA may contribute to neuropsychiatric disorders such as Alzheimer's disease and bipolar disorder.[ ... and blood coagulation in humans". Lipids. 32 (4): 421-5. doi:10.1007/s11745-997-0055-7. PMID 9113631. S2CID 4053608.. ... PGF2alpha promotes muscle protein synthesis by signaling through the Akt/mTOR pathway,[23] similar to leucine, β-hydroxy β- ... Kursun O, Karatas H, Bariskaner H, Ozturk S (2022). "Arachidonic acid metabolites in neurologic disorders". CNS & Neurological ...
https://en.m.wikipedia.org/wiki/Arachidonic_acid
Brain ischemiaBrain ischemia
Inflammatory Biomarkers - c-reactive protein, Interleukin 6, Tumor necrosis factor α,VCAM-1. Coagulation / Thrombosis ... Baldwin, Robert C. (2005). "Is vascular depression a distinct sub-type of depressive disorder? A review of causal evidence". ... Blood Biomarkers: Many proteins and RNA biomarkers identified are connected to ischemic stroke pathophysiology includes Central ... "Cerebral Hypoxia Information Page". National Institute of Neurological Disorders and Stroke. National Institutes of Health. ...
https://en.wikipedia.org/wiki/Brain_ischemia
ZTTK syndromeZTTK syndrome
The SON protein is mainly localised to nuclear speckles and involved in a variety of cellular processes such as transcription, ... The SON gene is known to be a major cause of severe intellectual disability and consequent developmental disorders. The first ... Decreased levels of immunoglobulin A and or immunoglobulin G identified in ZTTK syndrome patients resulted in coagulation ... The majority of SON variants found in ZTTK syndrome individuals are localised to exon 3. The SON gene encodes the SON protein, ...
https://en.wikipedia.org/wiki/ZTTK_syndrome
COVID-19COVID-19
... nucleocapsid protein (N), and the spike protein (S). The M protein of SARS-CoV-2 is about 98% similar to the M protein of bat ... Coagulation: During pregnancy, there are higher levels of circulating coagulation factors, and the pathogenesis of SARS-CoV-2 ... In people without prior ear, nose, and throat disorders, loss of taste combined with loss of smell is associated with COVID-19 ... interferon gamma-induced protein 10 (IP‑10), monocyte chemoattractant protein 1 (MCP1), macrophage inflammatory protein 1‑alpha ...
https://en.wikipedia.org/wiki/COVID-19
Jonathan RhoadsJonathan Rhoads
He made contributions in multiple other areas, including shock, burn, coagulation disorders and the use of sulfa to treat ... Nutrition including carbohydrates, fats, proteins, vitamins and minerals were successfully given directly into the circulatory ...
https://en.wikipedia.org/wiki/Jonathan_Rhoads
AntimicrobialAntimicrobial
In the presence of water, 70% alcohol causes coagulation of the proteins thus inhibiting microbial growth. Alcohols are not ... "Prospects and challenges for intestinal microbiome therapy in pediatric gastrointestinal disorders". World Journal of ... The mode of action is by denaturing the proteins. Alcohols interfere with the hydrogen bonds present in the protein structure. ... The growth of microorganisms is inhibited when iodine penetrates into the cells and oxidizes proteins, genetic material, and ...
https://en.wikipedia.org/wiki/Antimicrobial
Factor XIIIFactor XIII
Catridecacog Coagulation D-dimer Factor XIII deficiency Muszbek L, Bereczky Z, Bagoly Z, Komáromi I, Katona É (July 2011). " ... A units have a mass of about 83 kDa, 731 amino acid residues, 5 protein domains (listed from the N-terminal to C-terminal, ... with Iran having the highest global incidence of the disorder with 473 cases. The city of Khash, located in Sistan and ... Within blood, thrombins cleave fibrinogens to fibrins during coagulation and a fibrin-based blood clot forms. Factor XIII is a ...
https://en.wikipedia.org/wiki/Factor_XIII
Waldenström macroglobulinemiaWaldenström macroglobulinemia
A rare disorder, there are fewer than 1,500 cases occurring in the United States annually. The median age of onset is between ... Blood tests show the level of IgM in the blood and the presence of proteins, or tumor markers, that are the key signs of ... Coagulation abnormalities may be present. Prothrombin time, activated partial thromboplastin time, thrombin time, and ... Serum protein electrophoresis results indicate evidence of a monoclonal spike but cannot establish the spike as IgM. An M ...
https://en.wikipedia.org/wiki/Waldenström_macroglobulinemia
HemolysisHemolysis
The release of heme leads to the production of bilirubin and depletion of plasma proteins, such as albumin, haptoglobin, and ... Bossi, D; Russo, M (1996). "Hemolytic anemias due to disorders of red cell membrane skeleton". Molecular Aspects of Medicine. ... promotion of inflammation and coagulation, and thrombosis. Chronic hemolysis may also lead to endothelial dysfunction, ... Splenectomy of those with hemolytic disorders appears to increase risk of developing pulmonary thrombosis. Complications may ...
https://en.wikipedia.org/wiki/Hemolysis
Biomolecular condensateBiomolecular condensate
... and multivalent interactions between intrinsically disordered proteins (including cross-beta polymerisation), and/or protein ... The Structure of Colloidal matter and the Mechanism of Setting and of Coagulation". The Journal of Physiology. 24 (2): 158- ... Proteins regions identified as 'stickers' usually consist of Intrinsically Disordered Regions (IDRs) that act as "sticky" ... Garaizar A, Sanchez-Burgos I, Collepardo-Guevara R, Espinosa JR (October 2020). "Expansion of Intrinsically Disordered Proteins ...
https://en.wikipedia.org/wiki/Biomolecular_condensate
Plasma medicinePlasma medicine
Besides surgical plasma application like argon plasma coagulation (APC), which is based on high-intensity lethal plasma effects ... The Skin Center Dermatology Group (2020-03-25). "Using a Cold Atmospheric Plasma Device to Treat Skin Disorders". {{cite ... proteins, carbohydrates, lipids, and amino acids Plasma-assisted prodrug activation One of challenges is the application of non ... Zenker M, Argon plasma coagulation, GMS Krankenhaushyg Interdiszip 2008; 3(1):Doc15 (20080311) Fridman G, Friedman G, Gutsol A ...
https://en.wikipedia.org/wiki/Plasma_medicine
Multiple organ dysfunction syndromeMultiple organ dysfunction syndrome
In the absence of infection, a sepsis-like disorder is termed systemic inflammatory response syndrome (SIRS). Both SIRS and ... Measurements of lactate, cytokines, albumin and other proteins, urea, blood oxygen and carbon dioxide levels, insulin, and ... Stage 3: the patient develops shock with azotemia and acid-base disturbances; has significant coagulation abnormalities. Stage ... hence endotoxins have been advanced as principal mediator in this disorder. It is thought that following the initial event ...
https://en.wikipedia.org/wiki/Multiple_organ_dysfunction_syndrome
Embryonal fyn-associated substrateEmbryonal fyn-associated substrate
... allowing the CAS protein to function as a scaffold for other proteins including CRK proteins and C3G, a guanine nucleotide ... Another study has implicated EFS in the Chediak-Higashi syndrome (CHS). This rare and severe autosomal recessive disorder ... associated with partial albinism, peripheral neuropathy, mild coagulation defects and propensity to recurrent bacterial and ... In humans, the 561 amino acid EFS protein acts as a scaffolding protein for cell signaling based on interactions with SRC, FAK ...
https://en.wikipedia.org/wiki/Embryonal_fyn-associated_substrate
List of Ig Nobel Prize winnersList of Ig Nobel Prize winners
Ben-Soussan, E.; Antonietti, M.; Savoye, G.; Herve, S.; Ducrott??, P.; Lerebours, E. (2004). "Argon plasma coagulation in the ... Journal of Affective Disorders. 217: 289-294. doi:10.1016/j.jad.2017.04.017. ISSN 0165-0327. PMID 28441620. Eren, Metin I.; ... "Shear-Stress-Mediated Refolding of Proteins from Aggregates and Inclusion Bodies". ChemBioChem. 16 (3): 393-396. doi:10.1002/ ... Diagnostic Criteria for a New Psychiatric Disorder". PLOS ONE. 8 (1): e54706. Bibcode:2013PLoSO...854706S. doi:10.1371/journal. ...
https://en.wikipedia.org/wiki/List_of_Ig_Nobel_Prize_winners
Antiphospholipid syndromeAntiphospholipid syndrome
ApoH inhibits protein C, a glycoprotein with important regulatory function of coagulation (inactivates Factor Va and Factor ... Neurological Disorders Drug Targets. 15 (10): 1253-1265. doi:10.2174/1871527315666160920122750. PMID 27658514 - via PubMed. ... In APS there are also antibodies binding to protein S, which is a co-factor of protein C. Thus, anti-protein S antibodies ... Measuring serum levels of protein C, free and total protein S, factor VIII, antithrombin, plasminogen, tissue plasminogen ...
https://en.wikipedia.org/wiki/Antiphospholipid_syndrome
PrimidonePrimidone
Additionally, a coagulation defect resembling Vitamin K deficiency has been observed in newborns of mothers taking primidone. ... Schaffer LC; Schaffer CB; Caretto J (June 1999). "The use of primidone in the treatment of refractory bipolar disorder". Annals ... "Phenobarbital increases monkey in vivo nicotine disposition and induces liver and brain CYP2B6 protein". British Journal of ... Megaloblastic anemia is actually a group of related disorders with different causes that share morphological characteristics- ...
https://en.wikipedia.org/wiki/Primidone
Factor XIFactor XI
... a member of the serine protease inhibitor/serpin class of proteins), which is independent of protein Z (its action on factor X ... Like many other coagulation factors, it is a serine protease. In humans, Factor XI is encoded by the F11 gene. Factor XI (FXI) ... It is an autosomal recessive disorder. There is little spontaneous bleeding, but surgical procedures may cause excessive blood ... Factor XI or plasma thromboplastin antecedent is the zymogen form of factor XIa, one of the enzymes of the coagulation cascade ...
https://en.wikipedia.org/wiki/Factor_XI
Cerebral venous sinus thrombosisCerebral venous sinus thrombosis
... a tendency to develop blood clots due to abnormalities in coagulation, e.g. factor V Leiden, deficiency of protein C, protein S ... "COVID-19 Vaccine AstraZeneca: Risk of thrombocytopenia and coagulation disorders". European Medicines Agency (EMA). 24 March ... Any blood clot forms due to an imbalance between coagulation (the formation of the insoluble blood protein fibrin) and ... Disorders that cause, or increase the risk for systemic venous thrombosis are associated with central venous thromboses. In ...
https://en.wikipedia.org/wiki/Cerebral_venous_sinus_thrombosis
Gastric bypass surgeryGastric bypass surgery
In some cases, surgeons may recommend use of a liquid protein supplement. Powdered protein supplements added to smoothies or ... Any injury, such as a surgical operation, causes the body to increase the coagulation of the blood. Simultaneously, activity ... Chen M, Krishnamurthy A, Mohamed AR, Green R (July 2013). "Hematological Disorders following Gastric Bypass Surgery: Emerging ... adequate protein intake, and the use of vitamin and mineral supplements. Calcium supplements, iron supplements, protein ...
https://en.wikipedia.org/wiki/Gastric_bypass_surgery
MicroRNAMicroRNA
... binding protein], PACT (protein activator of the interferon-induced protein kinase), the SMN complex, fragile X mental ... In this disorder, the miRNAs have a dual role working as both tumor suppressors and oncogenes. Under a standard nomenclature ... miRNAs also play crucial roles in the regulation of complex enzymatic cascades including the hemostatic blood coagulation ... HMGA proteins (HMGA1a, HMGA1b and HMGA2) are implicated in cancer, and expression of these proteins is regulated by microRNAs. ...
https://en.wikipedia.org/wiki/MicroRNA
Periodontal diseasePeriodontal disease
Paraskevas S, Huizinga JD, Loos BG (April 2008). "A systematic review and meta-analyses on C-reactive protein in relation to ... Gingival diseases - Non dental biofilm induced Genetic/developmental disorders Specific infections Inflammatory and immune ... as it is associated with platelet and coagulation cascade activations, leading to thrombosis and thrombotic complications. ... Periodontitis has been linked to increased inflammation in the body, such as indicated by raised levels of C-reactive protein ...
https://en.wikipedia.org/wiki/Periodontal_disease
DeCS - Termos NovosDeCS - Termos Novos
COAGULATION PROTEIN DISORDERS. TRASTORNOS DE LAS PROTEINAS DE COAGULACION. TRANSTORNOS HEMOSTÁTICOS VASCULARES. VASCULAR ... ACTIVATED PROTEIN C RESISTANCE. RESISTENCIA A PROTEINA C ACTIVADA. RESSONÂNCIA DE PLASMÔNIO DE SUPERFÍCIE. SURFACE PLASMON ...
https://decs.bvs.br/P/decswebpage2p.htm
Long-Term Safety and Efficacy of Spark-Sponsored Gene Therapies in Males With Hemophilia A - Full Text View - ClinicalTrials.govLong-Term Safety and Efficacy of Spark-Sponsored Gene Therapies in Males With Hemophilia A - Full Text View - ClinicalTrials.gov
Blood Coagulation Disorders, Inherited. Blood Coagulation Disorders. Hematologic Diseases. Coagulation Protein Disorders. ... Such as: malignancies, neurologic, rheumatologic or other autoimmune, or hematologic disorders. *Annual bleeding rate [ Time ...
https://clinicaltrials.gov/ct2/show/NCT03432520
Blood smear: MedlinePlus Medical EncyclopediaBlood smear: MedlinePlus Medical Encyclopedia
Disorder in which the proteins that control blood clotting become overactive (disseminated intravascular coagulation) ... Disorder in which there is excessive breakdown of hemoglobin (thalassemia). *Disorder of the bone marrow in which the marrow is ... Blood disorder that causes blood clots to form in small blood vessels around the body and leads to a low platelet count ( ... Blood disorders. In: Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. Nelson Textbook of Pediatrics. 21st ...
https://medlineplus.gov/ency/article/003665.htm
Dermatologic Preoperative Evaluation and Management: Overview, General Health Assessment, Assessment of Operative Risk by...Dermatologic Preoperative Evaluation and Management: Overview, General Health Assessment, Assessment of Operative Risk by...
Severe liver disease is associated with decreased protein synthesis, which can manifest in disorders of coagulation and ... In general, bleeding disorders are due to abnormalities of the platelets, the intrinsic coagulation system, the extrinsic ... Many underlying diseases, inherited disorders, and medications can interfere with the normal coagulation process. ... Heat coagulation devices or carbon dioxide lasers provide safe alternatives for coagulation. Simple electrodesiccation of small ...
https://www.medscape.com/answers/1127055-156669/how-is-hypertension-addressed-during-the-dermatologic-preoperative-evaluation-and-management
Group B streptococcal septicemia of the newborn: MedlinePlus Medical EncyclopediaGroup B streptococcal septicemia of the newborn: MedlinePlus Medical Encyclopedia
Disseminated intravascular coagulation (DIC): A serious disorder in which the proteins that control blood clotting are ...
https://medlineplus.gov/ency/article/001366.htm
Part II: PUBLIC HEALTH ASSESSMENT Chapter 8 | CDCPart II: PUBLIC HEALTH ASSESSMENT Chapter 8 | CDC
... coagulation protein deficiencies due to liver failure, or an exclusive diagnosis of a platelet disorder are specifically ... diagnosed with a bleeding disorder due to congenital deficiency or acquired inhibitors in which any of the coagulation proteins ... Hemophilia refers to a group of rare hereditary disorders of blood coagulation. The most common are defects of clotting factors ... form of the disorder. Among the congenital bleeding disorders, von Willebrand disease (vWD) is the most common, affecting ...
https://www.cdc.gov/genomics/resources/books/21stcent/chap08.htm
JaypeeDigital | eBook ReaderJaypeeDigital | eBook Reader
Platelet Disorders. *Coagulation Protein Disorders. *Combined Platelet and Coagulation Factor Disorders. *Disorders of Vascular ...
https://jaypeedigital.com/eReader/chapter/9789389587234/ch1
Are ticks venomous animals? | Frontiers in Zoology | Full TextAre ticks venomous animals? | Frontiers in Zoology | Full Text
Many tick salivary protein families and their previously described functions are homologous to proteins found in scorpion, ... and tick salivary proteins, we consider that ticks should be referred to as venomous ectoparasites. ... Ticks are rarely considered as venomous animals despite that tick saliva contains several protein families present in venomous ... identification of the proteins potentially involved in the coagulation disorder and hemorrhagic syndrome. Gene. 2005, 1: 11-27. ...
https://frontiersinzoology.biomedcentral.com/articles/10.1186/1742-9994-11-47
Portal Regional da BVSPortal Regional da BVS
Factor VIII assayFactor VIII assay
This is one of the proteins in the body that helps the blood clot. Learn more. ... Disorder in which the proteins that control blood clotting become over active disseminated intravascular coagulation. (DIC) ... Coagulation and fibrinolysis. In: McPherson RA, Pincus MR, eds. Henrys Clinical Diagnosis and Management by Laboratory Methods ... This is one of the proteins in the body that helps the blood clot. ...
https://www.ucsfhealth.org/medical-tests/factor-viii-assay
DeCS - Termos Novos
COAGULATION PROTEIN DISORDERS. TRASTORNOS DE LAS PROTEINAS DE COAGULACION. TRANSTORNOS HEMOSTÁTICOS VASCULARES. VASCULAR ... ACTIVATED PROTEIN C RESISTANCE. RESISTENCIA A PROTEINA C ACTIVADA. RESSONÂNCIA DE PLASMÔNIO DE SUPERFÍCIE. SURFACE PLASMON ...
https://decs2017.bvsalud.org/P/decswebpage2p.htm
DeCSDeCS
Protein Disorder, Coagulation Protein Disorders, Coagulation Proteins Disorder, Coagulation Proteins Disorders, Coagulation ... Coagulation Protein Disorder Coagulation Proteins Disorder Coagulation Proteins Disorders Disorder, Coagulation Protein ... Coagulation Protein Disorder. Coagulation Proteins Disorder. Coagulation Proteins Disorders. Disorder, Coagulation Protein. ... Disorder, Coagulation Proteins. Disorders, Coagulation Protein. Disorders, Coagulation Proteins. Protein Disorder, Coagulation ...
https://decs.bvsalud.org/en/ths/resource/?id=33771&filter=ths_exact_term&q=TRASTORNOS+DE+LAS+PROTEINAS+DE+COAGULACION
DeCS - New Terms
COAGULATION PROTEIN DISORDERS. TRASTORNOS DE LAS PROTEINAS DE COAGULACION. TRANSTORNOS DE PROTEÍNAS DE COAGULAÇÃO. ... PROTEIN C DEFICIENCY. DEFICIENCIA DE PROTEINA C. DEFICIÊNCIA DE PROTEÍNA C. PROTEIN ISOFORMS. ISOFORMAS DE PROTEINAS. ISOFORMAS ... ACTIVATED PROTEIN C RESISTANCE. RESISTENCIA A PROTEINA C ACTIVADA. RESISTÊNCIA À PROTEÍNA C ATIVADA. ... MEROZOITE SURFACE PROTEIN 1. PROTEINA 1 DE SUPERFICIE DE MEROZOITO. PROTEÍNA 1 DE SUPERFÍCIE DE MEROZOITO. ...
https://decs2010.bvsalud.org/I/decswebpage2i.htm
DeCS - Termos Novos
COAGULATION PROTEIN DISORDERS. TRASTORNOS DE LAS PROTEINAS DE COAGULACION. TRANSTORNOS HEMOSTÁTICOS VASCULARES. VASCULAR ... ACTIVATED PROTEIN C RESISTANCE. RESISTENCIA A PROTEINA C ACTIVADA. RESSONÂNCIA DE PLASMÔNIO DE SUPERFÍCIE. SURFACE PLASMON ...
https://decs2007.bvsalud.org/P/decswebpage2p.htm
DeCS - Términos Nuevos
COAGULATION PROTEIN DISORDERS. TRANSTORNOS DE PROTEÍNAS DE COAGULAÇÃO. TRASTORNOS HEMOSTATICOS VASCULARES. VASCULAR HEMOSTATIC ... ACTIVATED PROTEIN C RESISTANCE. RESISTÊNCIA À PROTEÍNA C ATIVADA. RESONANCIA POR PLASMON DE SUPERFICIE. SURFACE PLASMON ...
https://decs2011.bvsalud.org/E/decswebpage2e.htm
DeCS - New Terms
COAGULATION PROTEIN DISORDERS. TRASTORNOS DE LAS PROTEINAS DE COAGULACION. TRANSTORNOS DE PROTEÍNAS DE COAGULAÇÃO. ... PROTEIN C DEFICIENCY. DEFICIENCIA DE PROTEINA C. DEFICIÊNCIA DE PROTEÍNA C. PROTEIN ISOFORMS. ISOFORMAS DE PROTEINAS. ISOFORMAS ... ACTIVATED PROTEIN C RESISTANCE. RESISTENCIA A PROTEINA C ACTIVADA. RESISTÊNCIA À PROTEÍNA C ATIVADA. ... MEROZOITE SURFACE PROTEIN 1. PROTEINA 1 DE SUPERFICIE DE MEROZOITO. PROTEÍNA 1 DE SUPERFÍCIE DE MEROZOITO. ...
https://decs2012.bvsalud.org/I/decswebpage2i.htm
DeCS - Termos Novos
COAGULATION PROTEIN DISORDERS. TRASTORNOS DE LAS PROTEINAS DE COAGULACION. TRANSTORNOS HEMOSTÁTICOS VASCULARES. VASCULAR ... ACTIVATED PROTEIN C RESISTANCE. RESISTENCIA A PROTEINA C ACTIVADA. RESSONÂNCIA DE PLASMÔNIO DE SUPERFÍCIE. SURFACE PLASMON ...
https://decs2015.bvsalud.org/P/decswebpage2p.htm
HuGE Navigator|Genopedia|PHGKBHuGE Navigator|Genopedia|PHGKB
Coagulation Protein Disorders 2 0 Chorioamnionitis 2 0 Choroidal Neovascularization 2 1 ...
https://phgkb.cdc.gov/PHGKB/huGEPedia.action?firstQuery=F2&geneID=2147&typeSubmit=GO&check=y&typeOption=gene&which=2&pubOrderType=pubD
DeCS - New Terms
COAGULATION PROTEIN DISORDERS. TRASTORNOS DE LAS PROTEINAS DE COAGULACION. TRANSTORNOS DE PROTEÍNAS DE COAGULAÇÃO. ... PROTEIN C DEFICIENCY. DEFICIENCIA DE PROTEINA C. DEFICIÊNCIA DE PROTEÍNA C. PROTEIN ISOFORMS. ISOFORMAS DE PROTEINAS. ISOFORMAS ... ACTIVATED PROTEIN C RESISTANCE. RESISTENCIA A PROTEINA C ACTIVADA. RESISTÊNCIA À PROTEÍNA C ATIVADA. ... MEROZOITE SURFACE PROTEIN 1. PROTEINA 1 DE SUPERFICIE DE MEROZOITO. PROTEÍNA 1 DE SUPERFÍCIE DE MEROZOITO. ...
https://decs2008.bvsalud.org/I/decswebpage2i.htm
DeCS - New Terms
COAGULATION PROTEIN DISORDERS. TRASTORNOS DE LAS PROTEINAS DE COAGULACION. TRANSTORNOS DE PROTEÍNAS DE COAGULAÇÃO. ... PROTEIN C DEFICIENCY. DEFICIENCIA DE PROTEINA C. DEFICIÊNCIA DE PROTEÍNA C. PROTEIN ISOFORMS. ISOFORMAS DE PROTEINAS. ISOFORMAS ... ACTIVATED PROTEIN C RESISTANCE. RESISTENCIA A PROTEINA C ACTIVADA. RESISTÊNCIA À PROTEÍNA C ATIVADA. ... MEROZOITE SURFACE PROTEIN 1. PROTEINA 1 DE SUPERFICIE DE MEROZOITO. PROTEÍNA 1 DE SUPERFÍCIE DE MEROZOITO. ...
https://decs2018.bvsalud.org/I/decswebpage2i.htm
DeCS - Términos Nuevos
COAGULATION PROTEIN DISORDERS. TRANSTORNOS DE PROTEÍNAS DE COAGULAÇÃO. TRASTORNOS HEMOSTATICOS VASCULARES. VASCULAR HEMOSTATIC ... ACTIVATED PROTEIN C RESISTANCE. RESISTÊNCIA À PROTEÍNA C ATIVADA. RESONANCIA POR PLASMON DE SUPERFICIE. SURFACE PLASMON ...
https://decs2019.bvsalud.org/E/decswebpage2e.htm
DeCS - Termos Novos
COAGULATION PROTEIN DISORDERS. TRASTORNOS DE LAS PROTEINAS DE COAGULACION. TRANSTORNOS HEMOSTÁTICOS VASCULARES. VASCULAR ... ACTIVATED PROTEIN C RESISTANCE. RESISTENCIA A PROTEINA C ACTIVADA. RESSONÂNCIA DE PLASMÔNIO DE SUPERFÍCIE. SURFACE PLASMON ...
https://decs2020.bvsalud.org/P/decswebpage2p.htm
DeCS - Términos Nuevos
COAGULATION PROTEIN DISORDERS. TRANSTORNOS DE PROTEÍNAS DE COAGULAÇÃO. TRASTORNOS HEMOSTATICOS VASCULARES. VASCULAR HEMOSTATIC ... ACTIVATED PROTEIN C RESISTANCE. RESISTÊNCIA À PROTEÍNA C ATIVADA. RESONANCIA POR PLASMON DE SUPERFICIE. SURFACE PLASMON ...
https://decs2016.bvsalud.org/E/decswebpage2e.htm
DeCS - New Terms
COAGULATION PROTEIN DISORDERS. TRASTORNOS DE LAS PROTEINAS DE COAGULACION. TRANSTORNOS DE PROTEÍNAS DE COAGULAÇÃO. ... PROTEIN C DEFICIENCY. DEFICIENCIA DE PROTEINA C. DEFICIÊNCIA DE PROTEÍNA C. PROTEIN ISOFORMS. ISOFORMAS DE PROTEINAS. ISOFORMAS ... ACTIVATED PROTEIN C RESISTANCE. RESISTENCIA A PROTEINA C ACTIVADA. RESISTÊNCIA À PROTEÍNA C ATIVADA. ... MEROZOITE SURFACE PROTEIN 1. PROTEINA 1 DE SUPERFICIE DE MEROZOITO. PROTEÍNA 1 DE SUPERFÍCIE DE MEROZOITO. ...
https://decs2013.bvsalud.org/I/decswebpage2i.htm
DeCS - New Terms
COAGULATION PROTEIN DISORDERS. TRASTORNOS DE LAS PROTEINAS DE COAGULACION. TRANSTORNOS DE PROTEÍNAS DE COAGULAÇÃO. ... PROTEIN C DEFICIENCY. DEFICIENCIA DE PROTEINA C. DEFICIÊNCIA DE PROTEÍNA C. PROTEIN ISOFORMS. ISOFORMAS DE PROTEINAS. ISOFORMAS ... ACTIVATED PROTEIN C RESISTANCE. RESISTENCIA A PROTEINA C ACTIVADA. RESISTÊNCIA À PROTEÍNA C ATIVADA. ... MEROZOITE SURFACE PROTEIN 1. PROTEINA 1 DE SUPERFICIE DE MEROZOITO. PROTEÍNA 1 DE SUPERFÍCIE DE MEROZOITO. ...
https://decs2014.bvsalud.org/I/decswebpage2i.htm
Vascular Complications in Kidney Transplantation | IntechOpenVascular Complications in Kidney Transplantation | IntechOpen
... states are caused by inherited thrombotic disorders due to mutations in genes encoding plasma proteins involved in coagulation ... protein C and protein S deficiency, and 2) increased levels or function of the coagulation factors: factor V Leiden, ... 0.54 for protein C deficiency, 0.50 for protein S deficiency, and 0.30 for activated protein C resistance or factor V Leiden ( ... Factor V-Leiden mutation or activated protein C resistance is the most common inherited thrombophilic disorder, found in 5% to ...
https://www.intechopen.com/chapters/19064
Pulmonary Embolism (PE): Practice Essentials, Background, AnatomyPulmonary Embolism (PE): Practice Essentials, Background, Anatomy
... of children with venous thromboembolic disease have inherited disorders of coagulation, such as antithrombin III, protein C, or ... Nuss R, Hays T, Chudgar U, Manco-Johnson M. Antiphospholipid antibodies and coagulation regulatory protein abnormalities in ... Primary or acquired deficiencies in protein C, protein S, and antithrombin III are other risk factors. Deficiency of these ... of children with a diagnosis of pulmonary embolism have antiphospholipid antibodies or coagulation-regulatory protein ...
http://reference.medscape.com/article/300901-overview
Code System Concept
Adverse reaction caused by coagulation protein (disorder). Code System Preferred Concept Name. Adverse reaction caused by ... Adverse reaction caused by coagulation protein Active Synonym false false 3703266015 Adverse reaction caused by clotting factor ...
https://phinvads.cdc.gov/vads/ViewCodeSystemConcept.action?oid=2.16.840.1.113883.6.96&code=770890009
Partial thromboplastin time (PTT) | Lima Memorial Health System
Disorder in which the proteins that control blood clotting become over active (disseminated intravascular coagulation) ... This is called the coagulation cascade. The PTT test looks at some of the proteins or factors involved in this process and ... Bleeding disorders, a group of conditions in which there is a problem with the bodys blood clotting process ... When you bleed, a series of actions involving many different proteins (clotting factors) take place in the body that helps the ...
https://www.limamemorial.org/health-library/HIE%20Multimedia-TextOnly/1/003653
DEFICIENCYHemophiliaPlateletsAlbuminWillebrandInhibitorsFibrinogenTreatment of coagulationAbnormalAbnormalitiesComplicationsClotting factorsDefectiveDefectsThrombinSymptomsAnticoagulantRecombinantDeficientAutoimmuneInfectionProthrombinClotSerumGeneticNeurologicalThrombocytopeniaInflammatoryHematologic disordersFibrinolysisCoagulopathiesDiseasesReceptorsAntibodiesCascadeHematologyEndothelialEndogenousAnemiaLaboratoryDefectGain of FunctIntrinsicSevereFibrinMUTATIONLiverOccurPlasma proteinHemostatic disordersHematological disordersRenal
DEFICIENCY32
  • Any known congenital or acquired coagulation disorder other than congenital FVIII deficiency. (checkorphan.org)
  • A deficiency of blood coagulation factor IX inherited as an X-linked disorder. (rush.edu)
  • This test is used to detect the causes of thromboembolism (Blood clotting disorders) and protein -C deficiency. (rtdiagnostics.net)
  • Two types of congenital Protein-C deficiency are either due to a reduction in Protein-C deficiency/activity or because of dysfunctional Protein-C, thus resulting in a condition called as activated protein-C resistance. (rtdiagnostics.net)
  • Hence these pathological conditions contribute in formation of frequent blood clots (thrombophilia) and thus these patients are to be monitored since they are at a very high risk of intravascular thrombus formation (thrombosis) leading to complications such as VTE (venous thrombo-embolism), DIC, DVT, pulmonary embolism, stroke, purpura fulminans, death of newborn (neonatal purpura in newborn babies could be a clinical manifestation for the deficiency of APC-Activated Protein-C) etc. (rtdiagnostics.net)
  • Coagulation factor VII deficiency is an inherited bleeding disorder affecting dogs. (pawprintgenetics.com)
  • Deficiency of this factor most commonly results in a mild bleeding disorder. (pawprintgenetics.com)
  • Veterinarians performing surgery on dogs that are known to have coagulation factor VII deficiency should have ready access to blood banked for transfusions. (pawprintgenetics.com)
  • Genetic testing of the F7 gene in dogs will reliably determine whether a dog is a genetic Carrier of coagulation factor VII deficiency. (pawprintgenetics.com)
  • Coagulation factor VII deficiency is inherited in an Autosomal Recessive manner in dogs meaning that they must receive two copies of the mutated gene (one from each parent) to develop the disease. (pawprintgenetics.com)
  • Withnall E, Giger U. Effects of recombinant human activated factor VII and canine fresh frozen plasma in Beagles with hereditary coagulation factor VII deficiency. (pawprintgenetics.com)
  • Most recently the Ginsburg laboratory has discovered mutations in the LMAN1 and MCFD2 genes as the cause of the human bleeding disorder combined deficiency of coagulation factors V and VIII, uncovering a novel pathway for the transport of selected proteins from the ER to Golgi. (the-asci.org)
  • Protein Deficiency Diseases are something everyone should be aware of in the modern world. (rebootwithnature.in)
  • Apart from being a disease in malnutrition countries, Protein Deficiency diseases and symptoms were recently observed in Diet Plans which don't follow the rules of the Balanced Diet Chart . (rebootwithnature.in)
  • It has been seen that children and elderly people are the ones who are most impacted by protein deficiency diseases. (rebootwithnature.in)
  • This article will look at the types of protein deficiency diseases in detail. (rebootwithnature.in)
  • The deficiency of adequate protein in the diet is the leading cause of death in children. (rebootwithnature.in)
  • Marasmus and Kwashiorkor are two primary signs of protein deficiency. (rebootwithnature.in)
  • Among Protein Deficiency Disease Symptoms, The major cause was a deficiency of protein and other micronutrients that included folate, iodine, vitamin C, and iron . (rebootwithnature.in)
  • Marasmus was another protein deficiency syndrome that affected adults and children who did not have adequate protein and calories in their diet. (rebootwithnature.in)
  • It was characterized by chronic fatigue, growth retardation, starvation, diarrhea, poor skin health , etc. ( 2 ) These diseases could be genetic protein deficiency diseases depending on your condition. (rebootwithnature.in)
  • Protein deficiency can also lead to anemia, wherein the cells of the body fail to get an adequate amount of oxygen. (rebootwithnature.in)
  • So, deficiency of protein in the diet also impacts this organ. (rebootwithnature.in)
  • This is another way in which protein deficiency can lead to weight gain. (rebootwithnature.in)
  • The purpura results from thrombotic vaso- occlusion associated with deficiency of protein C, protein S and antithrombin III. (dermnetnz.org)
  • Neurological symptoms of patients with protein S deficiency remain elusive. (jneuropsychiatry.org)
  • We report a female case with protein S deficiency who started having episodes of sudden nausea, white out of the whole visual field, loss of consciousness, and falling down with convulsion at the age of 18. (jneuropsychiatry.org)
  • Although both disorders involve deficiency of the same clotting factor, the bleeding pattern is quite different. (totheendsoftheearthmovie.com)
  • Hemophilia A/Factor VIII Deficiency is an inherited bleeding disorder in Boxers caused by a deficiency of the coagulation factor VIII (F8), a protein necessary for blood clotting. (ucdavis.edu)
  • Anemic disorders associated with orofacial signs and symptoms include iron deficiency anemia, Plummer-Vinson syndrome, megaloblastic anemia, sickle cell anemia, thalassaemia and aplastic anemia. (ijdr.in)
  • Iron deficiency anemia is the most common hematological disorder. (ijdr.in)
  • Hereditary tyrosinaemia type 1 (HT1) is a rare inherited genetic disorder attributed to deficiency of the enzyme fumarylacetoacetate hydrolase (FAH). (bvsalud.org)
Hemophilia19
  • Hemophilia refers to a group of rare hereditary disorders of blood coagulation. (cdc.gov)
  • Hemophilia B is a hereditary blood coagulation disorder. (health.am)
  • Hemophilia is a hereditary bleeding disorder of specific blood clotting factors. (health.am)
  • While rare, Hemophilia is the best-known coagulation disorder that is usually passed from parents to children. (americanmedical-id.com)
  • This resource is a joint effort of American Medical ID and the Hemophilia Federation of America to spread awareness of bleeding disorders, educate emergency responders about bleeding risks in Hemophilia and other blood disorders, and to improve the care and quality of life for all people with bleeding disorders. (americanmedical-id.com)
  • Hemophilia is a congenital bleeding disorder characterized by prolonged or spontaneous bleeding, especially into the muscles, joints or internal organs. (prnewswire.com)
  • CSL Behring therapies are indicated for the treatment of coagulation disorders including hemophilia and von Willebrand disease, primary immune deficiencies, hereditary angioedema and inherited respiratory disease. (prnewswire.com)
  • Those with bleeding disorders such as Hemophilia can range on a spectrum from light to severe, with many being diagnosed in infancy. (premedinc.com)
  • The annual BioRx Kids Hemophilia Calendar features artwork from children who either have a bleeding disorder or have a sibling or parent with a bleeding disorder. (hemophiliafed.org)
  • His research focuses on gene therapy for hemophilia, the biochemical basis of coagulation, and the immune responses to hemophilia therapies. (chop.edu)
  • Her basic science laboratory studies the molecular basis of coagulation, and she is the principal investigator of ongoing hemophilia A and B gene therapy trials. (chop.edu)
  • The research in the Sabatino Laboratory is focused on hemophilia, an inherited bleeding disorder. (chop.edu)
  • The interests of the laboratory include the study of variants of coagulation factor VIII to understand the biochemical properties of these proteins and to identify novel variants with enhanced function, and the development of gene-based therapeutic approaches for treating hemophilia. (chop.edu)
  • Acquired hemophilia (AH) is a rare autoimmune disorder characterized by bleeding that occurs in patients with no personal or family history of diseases related to clotting/coagulation. (totheendsoftheearthmovie.com)
  • AH is different from congenital hemophilia, a group of rare genetic disorders caused by mutations in the genes encoding certain clotting factors. (totheendsoftheearthmovie.com)
  • The main form of hemophilia is hemophilia A (classic hemophilia), which is an X-linked disorder that mostly affects males but can also affect females. (totheendsoftheearthmovie.com)
  • People who have hemophilia, may not produce the coagulation protein needed for this process. (nhfcentralohio.org)
  • helps patients living with congenital bleeding disorders, like hemophilia A and B and von Willebrand's disease. (blood.ca)
  • Orofacial petechiae, conjunctivae hemorrhage, nose-bleeding, spontaneous and post-traumatic gingival hemorrhage and prolonged post-extraction bleeding are common orofacial manifestations of inherited hemostatic disorders such as von Willebrand's disease and hemophilia. (ijdr.in)
Platelets10
  • If a person is missing or is deficient in one of these proteins or platelets, or they do not function properly, a normal blood clot will not form. (americanmedical-id.com)
  • Von Willebrand factor, a large plasma protein synthesized by endothelium, facilitates adhesion between platelets and subendothelium. (vin.com)
  • How It Works During a coagulation blood test, a blood sample is taken and sent to the lab to discover any abnormalities in the level of platelets in the blood or the level of blood clotting agents in the body. (walkinlab.com)
  • Blood clotting involves both cellular platelets and a protein called fibrin. (walkinlab.com)
  • A LUPUS blood test includes: Antinuclear Antibodies (ANA) Direct, Complete Blood Count with Differential and Platelets (CBC), Urinalysis Complete, Rheumatoid Arthritis (RA) Factor, Sedimentation Rate (ESR), C-Reactive Protein (CRP) High Sensitivity Cardiac Risk, Comprehensive Metabolic Panel - 14 tests, Prothrombin Time (PT) and Partial Thromboplastin Time (PTT). (walkinlab.com)
  • the public sector is principally focused on blood collection (used for transfusion of red cells and blood platelets) whereas the private sector is focused mainly on plasma (used to purify and concentrate a large array of human plasma proteins), and they do not agree on many policies related to plasma collection and usage[8]. (pharmexec.com)
  • Limit the blood's ability to clot (to stop bleeding with platelets or clotting proteins). (ohsu.edu)
  • It happens due to excessive clumping of platelets (blood cells) or other blood proteins within the blood vessels. (netmeds.com)
  • In March 2021, fol owing reports of rare blood coagulation disorders in a few individuals who had received the AZ vaccine in Europe, the WHO's Global Advisory Committee on Vaccine Safety (GACVS) and European Medicines Agency (EMA) reviewed al available information and data on thromboembolic events (blood clots) and thrombocytopenia (low platelets) after vaccination. (who.int)
  • Biologic results showed an increased neutrophil count (14.5 ×10 9 cells/L), thrombocytopenia (25 × 10 9 platelets/L), and an inflammatory syndrome (C-reactive protein level 49.7 mg/L). There was no renal dysfunction and no increases in levels of serum lactate or abnormalities in levels of cardiac, hepatic, and pancreatic enzymes. (cdc.gov)
Albumin6
  • June 8, 2012 /PRNewswire/ -- CSL Behring announced today that the company has been granted Orphan Drug Designation by the United States Food and Drug Administration for its novel recombinant fusion protein linking coagulation factor IX with recombinant albumin ( rIX-FP ). (prnewswire.com)
  • Albumin has been chosen as the ideal recombinant genetic fusion partner for coagulation factor proteins due to its long physiological half-life. (prnewswire.com)
  • The cleavable linker connecting recombinant factor IX and recombinant albumin has been specifically designed to preserve the native function of the coagulation factor in the fusion protein, while benefiting from recombinant albumin's long physiological half-life. (prnewswire.com)
  • Different blood plasma components are divided into numerous types such as antibodies (immunoglobulins), albumin and coagulation proteins and then further distributed according to medical need in complex acute and chronic indications spanning e.g. haematology, immunology and neurology. (pharmexec.com)
  • A/G Ratio: The ratio of albumin to globulin (A/G ratio) is calculated from values obtained by direct measurement of total protein and albumin. (baysport.com)
  • More specific tests, such as albumin, liver enzyme tests, and serum protein electrophoresis must be performed to make an accurate diagnosis. (baysport.com)
Willebrand5
  • Among the congenital bleeding disorders, von Willebrand disease (vWD) is the most common, affecting perhaps as much as 1% - 3% of the U.S. population (2-4) . (cdc.gov)
  • Early in his career, Dr. Ginsburg cloned the von Willebrand factor gene and began to define the molecular genetic basis for von Willebrand disease, the most common inherited bleeding disorder in humans. (the-asci.org)
  • Studies of von Willebrand factor variation led to the identification of a genetic alteration in glycosyltransferase function in the mouse, one of the few successful definitions of a genetic modifier, with potentially broad implications for a variety of human disorders. (the-asci.org)
  • Von Willebrand disease is the most common bleeding disorder in the U.S., affecting about one in every 100 people. (ohsu.edu)
  • This gene mutation affects your child's ability to make a clotting protein called von Willebrand factor. (ohsu.edu)
Inhibitors2
  • The coagulation system is governed by a subtle balance between clotting activators and inhibitors. (medecinesciences.org)
  • An increase in coagulation factor (gain function) or/and a decrease in coagulation inhibitors (loss of function) may favor venous thromboembolism (VTE). (medecinesciences.org)
Fibrinogen1
  • The Fibrinogen Activity Test is used to check for fibrinogen, coagulation factor, a protein that is essential for blood clot formation. (walkinlab.com)
Treatment of coagulation1
  • Dr. Margaritis uses biochemical, molecular, and complex in vivo methodology within the field of coagulation to advance the understanding of molecular mechanisms involved in pro- and anti-coagulant reactions, and translate research for the treatment of coagulation defects. (chop.edu)
Abnormal4
  • Persons diagnosed with bleeding disorders are at risk of abnormal bleeding both outside and inside the body. (americanmedical-id.com)
  • The guide commences with the red cell series and describes normoblastic erythropoiesis, abnormal erythropoiesis and all the red cell disorders associated with anaemia. (mewsie.org)
  • Although it is known that M-proteins can cause abnormal laboratory results, the impact of M-protein on coagulation test results is different in individual patients ( 6 ). (biochemia-medica.com)
  • As a result, it improves blood flow and oxygen supply through the blood vessels and reduce the symptoms of blood clotting disorders such as deep vein thrombosis, pulmonary embolism, heart attack, abnormal heart rate or stroke. (netmeds.com)
Abnormalities3
  • Hemorrhagic and thrombotic disorders resulting from abnormalities or deficiencies of coagulation proteins. (bvsalud.org)
  • Moreover, other associated tests include Protein-C antigenic assay (which is not based on function or activity and helps to distinguish between type-1 and type-2 PC abnormalities) is performed by ELISA, radial immunodiffusion - RID etc. (rtdiagnostics.net)
  • and in its severe forms, other abnormalities such as coagulation or liver function disorders. (automesure.com)
Complications3
  • Although bleeding disorders can have similar symptoms and complications, they are also all different. (americanmedical-id.com)
  • Common injuries that seem normal for most people like simple cuts or bumping a body part can sometimes cause serious complications for a person with a bleeding disorder. (americanmedical-id.com)
  • The data of this patient suggest relationship among focal seizures, psychological complications, coagulation disorders, and brain ischemic lesion, which should be further investigated. (jneuropsychiatry.org)
Clotting factors6
  • This effect is related to the differential half-lives of protein C, protein S, and the vitamin K-dependent clotting factors II, VII, IX, and X. Long-term anticoagulation is definitely indicated for patients with recurrent venous thrombosis and/or persistent or irreversible risk factors. (medscape.com)
  • When you bleed, a series of actions involving many different proteins (clotting factors) take place in the body that helps the blood clot. (limamemorial.org)
  • Thus upon activation APC (activated protein-C) forms a complex with protein-S on a phospholipid surface and hence rapidly it inactivates blood clotting factors such as factor Va and factor VIIIa. (rtdiagnostics.net)
  • Clotting factors are specialized proteins required for the blood to clot normally. (totheendsoftheearthmovie.com)
  • Clotting factors, such as factor VIII, are specialized proteins that are essential for the blood to clot properly. (totheendsoftheearthmovie.com)
  • It occurs when the immune system produces antibodies that mistakenly attack healthy tissue, specifically specialized proteins known as clotting factors, most often clotting factor VIII. (totheendsoftheearthmovie.com)
Defective2
  • The disorder is caused by an inherited X-linked recessive trait, with the defective gene located on the X chromosome. (health.am)
  • The disease is caused by deficient or defective blood coagulation proteins known as factor VIII or IX. (prnewswire.com)
Defects2
  • The combined prevalence for these two single-gene, single-protein, x-chromosome-linked defects is estimated to be 13 cases per 100,000 males or approximately 17,000 cases in the United States. (cdc.gov)
  • Bleeding disorders encompass a large number of blood-related defects and deficiencies that can affect persons in a variety of ways. (premedinc.com)
Thrombin9
  • ATIII, the body's primary anticoagulant, inactivates thrombin and inhibits the activity of activated factor X in the coagulation process. (medscape.com)
  • Protein C (PC) is a 62 KDa, vitamin K-dependent plasma serine protease that is transformed to its active form, activated protein C (APC) by the thrombomodulin-thrombin complex on the surface of endothelial cells [ 1 , 2 ]. (aging-us.com)
  • As part of the anticoagulant system, APC, together with various cofactors, such as protein S, factor V (FV), and phosphatidylserine, degrades factors Va and VIIIa and inhibits the production of thrombin [ 4 ]. (aging-us.com)
  • Protein S (PS) is an extensively studied protein with an important function in the down-regulation of thrombin generation. (stoptheclot.org)
  • Protein-C (PC) is also known as auto-pro-thrombin IIA and/or blood coagulation factor XIX). (rtdiagnostics.net)
  • Protein-C activity: Protein-C serine protease pro-enzyme is converted to activate form i.e activated protein-C (APC) by thrombin and thrombomodulin. (rtdiagnostics.net)
  • Protein-C is activated when it binds to thrombin. (rtdiagnostics.net)
  • Many genes can contribute to the overall phenotype, and polymorphisms may act to up regulate or down regulate the generation of thrombin, the coagulation-key enzyme. (medecinesciences.org)
  • Results of thrombophilia screening (standard blood coagulation tests and tests for antibodies against thrombin III and phospholipid) were negative. (cdc.gov)
Symptoms3
  • Call your health care provider if symptoms of a bleeding disorder develop. (health.am)
  • The importance of understanding the orofacial manifestations of these disorders also lies in the fact that orofacial signs and symptoms may be the first clinical presentation that alerts the dentist/hematologist to an underlying hematological disorder. (ijdr.in)
  • 12250 ='Vertigo - dizziness' 12300 ='Weakness (neurologic)' 12350 ='Disorders of speech, speech disturbance' 12351 ='Stuttering, stammering' 12352 ='Slurring' 12400 ='Other symptoms referable to the nervo. (cdc.gov)
Anticoagulant5
  • Activated protein C (APC) is an anticoagulant with potent cytoprotective and anti-inflammatory effects. (aging-us.com)
  • Reduced anticoagulant activity of APC has been implicated in various coagulation disorders. (aging-us.com)
  • Additional tests include chromogen (amidolytic) based assay - the formation of chromogenic colour is proportional to the amount of Activated protein-C - APC (hence Protein-C) in the plasma sample specimen (test results can be interfered with by hemolysis, lipemia, icterus etc), partially activated Protein-C test, antithrombin, lupus anticoagulant, antiphospholipid antibodies, factor V Leiden test, prothrombin test etc. (rtdiagnostics.net)
  • It is used for assessment of clotting disorders and monitoring of patients taking oral anticoagulant therapy (OAT) with vitamin K antagonists (VKAs) ( 1 ). (biochemia-medica.com)
  • Unreliable, incorrect and even unmeasurable PT result in a patient taking VKAs as well as in a patient not taking any anticoagulant therapy, may be caused by inadequate or improper sample for coagulation testing or by endogenous or exogenous interferences. (biochemia-medica.com)
Recombinant1
  • Received COVID-19 vaccine manufactured bu other companies (include mRNA, recombinant protein vaccines, vector vaccines, inactivated vaccines, etc. (who.int)
Deficient4
  • The BN ProSpec ® is a dedicated, compact system that offers a consolidated menu of specialty and routine reagents for reliable plasma protein testing including cardiac risk assessment, kidney diseases, nutritional assessment and iron and anemia assessment as well as innovative markers such as monoclonal kappa and lambda free light chains, Cystatin C and Carbohydrate-Deficient Transferrin (CDT). (siemens-healthineers.com)
  • It is called a protein-deficient diet. (rebootwithnature.in)
  • A protein-deficient diet is very low in proteins. (rebootwithnature.in)
  • The above described coagulation process explains why hemophilic (factor VIII and IX deficient) or factor VII deficient animals bleed, whereas factor XII deficient animals do not. (vin.com)
Autoimmune4
  • Autoimmune disorders occur when the body's immune system mistakenly attacks healthy cells or tissue. (totheendsoftheearthmovie.com)
  • AH is an autoimmune disorder. (totheendsoftheearthmovie.com)
  • helps patients living with primary and secondary immunodeficiency disorders, autoimmune disorders and neurological disorders, among other medical conditions. (blood.ca)
  • Five serious adverse events were reported, of which two were in the vaccine group (pyrexia and transverse myelitis) and three were in the control group (autoimmune haemolytic anaemia, increased C- reactive protein and myelitis). (who.int)
Infection3
  • The lysosomal degradation pathway of autophagy has a crucial role in different pathophysiological conditions, such as infection, neurodegenerative disorders, cancer and ageing. (hrb.ie)
  • Researchers believe that a triggering event (such as an infection or underlying disorder) may induce the immune system to produce autoantibodies. (totheendsoftheearthmovie.com)
  • Then they are retested for infectious agents to ensure proteins are purified and will not cause infection, so that patients are protected. (blood.ca)
Prothrombin2
  • Prothrombin time (PT) is the most frequently performed global coagulation test. (biochemia-medica.com)
  • It blocks the actions of certain blood proteins and enzymes (such as vitamin k reductase, prothrombin, coagulation factors VII, IX, X and protein C) that forms blood clots in the body. (netmeds.com)
Clot5
  • This is one of the proteins in the body that helps the blood clot. (ucsfhealth.org)
  • The PTT test looks at some of the proteins or factors involved in this process and measures their ability to help blood clot. (limamemorial.org)
  • Venous blood samples for laboratory testing were collected in Vacuette tubes (Greiner Bio-One, Kremsmünster, Austria) containing 3.2%-trisodium citrate (coagulation testing, volume 1.8 mL), K 3 EDTA (haematology, volume 2 mL), a clot activator and Li-heparin (biochemistry, volumes 7 and 5 mL, respectively). (biochemia-medica.com)
  • With larger vessel injury, coagulation factors are also needed to form a stable fibrin clot, known as secondary hemostasis. (vin.com)
  • In the case of many blood disorders, this essentially means your blood cannot clot on its own. (premedinc.com)
Serum2
  • For example, serum biomarkers, such as high sensitivity C-reactive protein (hsCRP) and cytokine levels, predict progression of atherosclerosis and risk of stroke. (medscape.com)
  • Further laboratory diagnostics revealed total serum proteins at concentration of 123 g/L and the presence of M-protein IgG lambda (λ) at concentration of 47.1 g/L. These results suggested monoclonal gammopathy as an underlying pathophysiological condition in our patient. (biochemia-medica.com)
Genetic3
  • Bleeding disorders are usually genetic. (americanmedical-id.com)
  • Donner J, Kaukonen M, Anderson H, Moller F, Kyostila K, Sankari S, Hytonen M, Giger U, Lohi H. Genetic Panel Screening of Nearly 100 Mutations Reveals New Insights into the Breed Distribution of Risk Variants for Canine Hereditary Disorders. (pawprintgenetics.com)
  • Blood disorders are often associated with platelet issues and genetic or familial tendencies. (premedinc.com)
Neurological3
  • His special interest in neurological disorders of children was apparent. (jicna.org)
  • In his second textbook titled Diseases of the Nervous System in Infancy, Childhood, and Adolescence, published in 1937, he grouped neurological disorders based on etiology and pathogenesis. (jicna.org)
  • This early appreciation for categorizing disorders by etiology created a paradigm shift in the pursuit of deciphering the pathogenesis of neurological disorders of the developing brain. (jicna.org)
Thrombocytopenia1
  • buy friction stir welding and requirements and dynamic years to immerse neurons, agreements, and icebreakers have about their disorders with pharmaceutical thrombocytopenia. (wickedchopspoker.com)
Inflammatory5
  • Activated protein-C (APC) other than regulating blood clotting, and apoptosis (programmed cell death), has Cytoprotective effects (anti-inflammatory effects on endothelial cells and leucocytes), and it is also involved in process inflammation, thus it has a modulatory role in inflammation (pro-inflammatory and anti-inflammatory actions. (rtdiagnostics.net)
  • This results in multi-organ damage caused by the cytotoxic effect of the heat compounded by the inflammatory and coagulation responses of the host. (who.int)
  • Furthermore, nitrite pretreatment also showed significant alleviation of AMI-induced signal protein expressions of inflammatory factors of NF-KB and oxidative factors of Hsp 70 and HO-1. (cdc.gov)
  • Karachi is a heavily populated city effect of the heat compounded by the inflammatory and and suffered significantly due to a high heat index, ur- coagulation responses of the host. (who.int)
  • Diabetes patients experience a variety of internal health issues, including immune deficiencies, inflammatory storms, hyperglycemia, coagulation risks, and elevated levels of ACE2 receptors. (medrech.com)
Hematologic disorders1
  • His clinical and research expertise and interests are in hereditary and hematologic disorders of small animals. (vin.com)
Fibrinolysis1
  • Napolitano M, Schmaier AH, Kessler CM. Coagulation and fibrinolysis. (ucsfhealth.org)
Coagulopathies2
  • Activated Protein-C prevents coagulopathies. (rtdiagnostics.net)
  • One of the most important procedures is a careful history taking to collect information on any previous3 history of bleeding episodes occurred with the patient and/or family, the use of medication that interferes with coagulation, coagulopathies, and specific systemic diseases, such as arterial hypertension, liver diseases and leukemia. (bvsalud.org)
Diseases4
  • It is also relatively common among persons with chronic mental disorders or cardiopulmonary diseases and those receiving medications that interfere with salt and water balance, such as diuretics, anti-cholinergic agents, and tranquilizers that impair sweating (6). (who.int)
  • The aim of this paper is to review the literature and identify orofacial manifestations of hematological diseases, with particular reference to anemias and disorders of hemostasis. (ijdr.in)
  • orofacial diseases AND anaemic disorders. (ijdr.in)
  • It is lives of people with more episodes of heat-related illness- also relatively common among persons with chronic es being recorded and an average temperature increase mental disorders or cardiopulmonary diseases and those of 0.8°C has been noted since the 20th century ( 1-3 ). (who.int)
Receptors2
  • Other factors that stimulate Protein-C activation are thrombomodulin, endothelial protein-C receptors (present in the blood vessels) etc. (rtdiagnostics.net)
  • Its activity is directed by intracellular signals mediated by various types of receptors such as G protein-coupled receptors. (embl.de)
Antibodies1
  • The immune system normally responds to a foreign substance by producing specialized proteins called antibodies. (totheendsoftheearthmovie.com)
Cascade3
  • This is called the coagulation cascade. (limamemorial.org)
  • The coagulation cascade is a series of enzymatic reactions involving coagulation factors, denoted by Roman numerals. (vin.com)
  • The coagulation cascade can be divided into an extrinsic and intrinsic system that merges into the common pathway. (vin.com)
Hematology1
  • Hematology Case Studies with Blood Cell Morphology and Pathophysiology compiles specialized case studies with specific information on various hematological disorders with Full Blood Examination (FBE or CBC), blood film images and pathophysiology of each condition. (mewsie.org)
Endothelial2
  • PC activation is further enhanced by its binding to endothelial protein C receptor (EPCR) [ 3 ]. (aging-us.com)
  • The increased risk ofacceleration and extension of atherosclerosis in patients with SCH and CH could be explained by dyslipidemia,diastolic hypertension, increased arterial stiffness, endothelial dysfunction, and altered blood coagulation. (ac.rs)
Endogenous1
  • Rarely, monoclonal protein (M-protein) can be the cause of endogenous interference on coagulation and other laboratory test results due to high sample viscosity, precipitation and reaction with reagent components ( 3 ). (biochemia-medica.com)
Anemia2
  • He also investigates additional disorders such as anemia of inflammation and hemochromatosis. (chop.edu)
  • In this review of orofacial manifestations of hematological disorders, orofacial manifestations of anemia and disorders of hemostasis are discussed. (ijdr.in)
Laboratory4
  • The Ginsburg laboratory also cloned and characterized the gene for plasminogen activator-inhibitor (PAI-1) and defined a number of critical functional domains within the corresponding protein. (the-asci.org)
  • Microscopic Haematology, 3rd Edition: A practical guide for the laboratory also offers a section on paediatric haematology, outlining red cell, white cell and platelet disorders occurring in cord blood, the neonate and childhood. (mewsie.org)
  • Alternative proteins and molecules are created in a laboratory. (blood.ca)
  • During heat waves, coagulation (DIC) based on clinical examination and major risk factors for heat stroke include heat exposure, laboratory data. (who.int)
Defect1
  • Once the defect has been identified, other family members will need less testing to diagnose the disorder. (health.am)
Gain of Funct1
  • A, two gain of function mutations, challenged the view of thrombophilia as a rare monogenic disorder. (medecinesciences.org)
Intrinsic2
  • Thus this test activates both Protein-C and factors of the intrinsic pathway. (rtdiagnostics.net)
  • The other contact phase coagulation factors include factor XII, prekallikrein and High Molecular Weight Kininogen and are in vivo of lesser importance in the activation of the intrinsic system. (vin.com)
Severe3
  • Heat stroke is a result of the failure of the body to regulate its temperature accordingly along with a severe acute-phase response that culminates in release of heat-shock proteins (7). (who.int)
  • Severe coagulation disorder associated with disseminated intravascular coagulation may result in purpura fulminans with generalised , large spontaneous ecchymoses and external bleeding. (dermnetnz.org)
  • Because horses' feeding habits and digestive systems are different, feeding practices common to other farm species can cause severe digestive disorders and even death in some cases. (bestfriendequine.com)
Fibrin1
  • In contrast, significantly prolonged TT results in all analysed samples suggest impact of M-protein on this global coagulation test due to possible effect on fibrin polymerization. (biochemia-medica.com)
MUTATION1
  • Avec la découverte de deux mutations fréquentes, le FV Leiden et la mutation g.20210 G → A du gène de la prothrombine (F2), apparaît la notion de facteur de prédisposition génétique dont l'impact est démontré par des études épidémiologiques, mais dont la traduction clinique en termes de thrombose est beaucoup plus complexe. (medecinesciences.org)
Liver3
  • Protein-C is a pro-enzyme (zymogen precursor) of serine protease synthesized by the liver which has multiple domains. (rtdiagnostics.net)
  • On the contrary, people who consumed diets rich in animal-derived protein were associated with early mortality, osteoporosis, liver and kidney malfunction, colon cancer, and more. (rebootwithnature.in)
  • LDL-Cholesterol is a transport protein that carries cholesterol from the liver to the arteries, where it is ultimately deposited. (baysport.com)
Occur1
  • Bleeding disorders occur more commonly in dogs than in cats. (vin.com)
Plasma protein10
  • CSL Behring is a leader in the plasma protein therapeutics industry. (prnewswire.com)
  • What are plasma protein and related products? (blood.ca)
  • Plasma protein and related products are medications made from proteins in human plasma, or an alternative. (blood.ca)
  • Today, more than 20 of these proteins can be purified and prepared for use as a plasma protein product that is tailor-made for patients with specific needs. (blood.ca)
  • An ever-increasing number of plasma protein and related products are being developed. (blood.ca)
  • From start to finish, making plasma protein products is a rigorous multi-stepped process that can take upwards of nine months from the time plasma is collected from a donor. (blood.ca)
  • Each protein is the special ingredient needed to make one type of plasma protein product. (blood.ca)
  • Pure and safe plasma protein products are packaged, labelled and ready for use by clinicians and patients. (blood.ca)
  • The remaining steps are performed externally by manufacturers of plasma protein products. (blood.ca)
  • Canadian Blood Services is responsible for securing and providing plasma protein and related products to hospitals across Canada for use by clinicians and their patients in all provinces and territories (except Quebec). (blood.ca)
Hemostatic disorders2
  • Hemorrhagic presentations may suggest certain hemostatic disorders and practical tests are available to characterize the bleeding tendency. (vin.com)
  • A wide array of anemic and hemostatic disorders encountered in internal medicine has manifestations in the oral cavity and the facial region. (ijdr.in)
Hematological disorders1
  • Moreover, it can be used as a reference book by technicians, scientists and hematologists in every level of expertise in diagnosing hematological disorders. (mewsie.org)
Renal1
  • The pathogenesis is multifactorial, with hypovolaemia, hypotension, myoglobinuria, and disseminated intravascular coagulation contributing to the event of renal failure. (edu.hk)