Coagulation Protein Disorders: Hemorrhagic and thrombotic disorders resulting from abnormalities or deficiencies of coagulation proteins.Blood Coagulation: The process of the interaction of BLOOD COAGULATION FACTORS that results in an insoluble FIBRIN clot.Blood Coagulation Factors: Endogenous substances, usually proteins, that are involved in the blood coagulation process.Vitamin K: A lipid cofactor that is required for normal blood clotting. Several forms of vitamin K have been identified: VITAMIN K 1 (phytomenadione) derived from plants, VITAMIN K 2 (menaquinone) from bacteria, and synthetic naphthoquinone provitamins, VITAMIN K 3 (menadione). Vitamin K 3 provitamins, after being alkylated in vivo, exhibit the antifibrinolytic activity of vitamin K. Green leafy vegetables, liver, cheese, butter, and egg yolk are good sources of vitamin K.Databases, Protein: Databases containing information about PROTEINS such as AMINO ACID SEQUENCE; PROTEIN CONFORMATION; and other properties.Factor IX: Storage-stable blood coagulation factor acting in the intrinsic pathway. Its activated form, IXa, forms a complex with factor VIII and calcium on platelet factor 3 to activate factor X to Xa. Deficiency of factor IX results in HEMOPHILIA B (Christmas Disease).Prothrombin: A plasma protein that is the inactive precursor of thrombin. It is converted to thrombin by a prothrombin activator complex consisting of factor Xa, factor V, phospholipid, and calcium ions. Deficiency of prothrombin leads to hypoprothrombinemia.Sequence Analysis, Protein: A process that includes the determination of AMINO ACID SEQUENCE of a protein (or peptide, oligopeptide or peptide fragment) and the information analysis of the sequence.Prothrombin Time: Clotting time of PLASMA recalcified in the presence of excess TISSUE THROMBOPLASTIN. Factors measured are FIBRINOGEN; PROTHROMBIN; FACTOR V; FACTOR VII; and FACTOR X. It is used for monitoring anticoagulant therapy with COUMARINS.Factor X: Storage-stable glycoprotein blood coagulation factor that can be activated to factor Xa by both the intrinsic and extrinsic pathways. A deficiency of factor X, sometimes called Stuart-Prower factor deficiency, may lead to a systemic coagulation disorder.Carbon-Carbon Ligases: Enzymes that catalyze the joining of two molecules by the formation of a carbon-carbon bond. These are the carboxylating enzymes and are mostly biotinyl-proteins. EC 6.4.Proteins: Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.Disseminated Intravascular Coagulation: A disorder characterized by procoagulant substances entering the general circulation causing a systemic thrombotic process. The activation of the clotting mechanism may arise from any of a number of disorders. A majority of the patients manifest skin lesions, sometimes leading to PURPURA FULMINANS.Factor XI: Stable blood coagulation factor involved in the intrinsic pathway. The activated form XIa activates factor IX to IXa. Deficiency of factor XI is often called hemophilia C.Blood Protein DisordersProtein C: A vitamin-K dependent zymogen present in the blood, which, upon activation by thrombin and thrombomodulin exerts anticoagulant properties by inactivating factors Va and VIIIa at the rate-limiting steps of thrombin formation.1-Carboxyglutamic Acid: Found in various tissues, particularly in four blood-clotting proteins including prothrombin, in kidney protein, in bone protein, and in the protein present in various ectopic calcifications.Thromboplastin: Constituent composed of protein and phospholipid that is widely distributed in many tissues. It serves as a cofactor with factor VIIa to activate factor X in the extrinsic pathway of blood coagulation.Factor VIII: Blood-coagulation factor VIII. Antihemophilic factor that is part of the factor VIII/von Willebrand factor complex. Factor VIII is produced in the liver and acts in the intrinsic pathway of blood coagulation. It serves as a cofactor in factor X activation and this action is markedly enhanced by small amounts of thrombin.Factor V: Heat- and storage-labile plasma glycoprotein which accelerates the conversion of prothrombin to thrombin in blood coagulation. Factor V accomplishes this by forming a complex with factor Xa, phospholipid, and calcium (prothrombinase complex). Deficiency of factor V leads to Owren's disease.Blood Coagulation Disorders: Hemorrhagic and thrombotic disorders that occur as a consequence of abnormalities in blood coagulation due to a variety of factors such as COAGULATION PROTEIN DISORDERS; BLOOD PLATELET DISORDERS; BLOOD PROTEIN DISORDERS or nutritional conditions.Thrombin: An enzyme formed from PROTHROMBIN that converts FIBRINOGEN to FIBRIN.Blood Coagulation Tests: Laboratory tests for evaluating the individual's clotting mechanism.Computational Biology: A field of biology concerned with the development of techniques for the collection and manipulation of biological data, and the use of such data to make biological discoveries or predictions. This field encompasses all computational methods and theories for solving biological problems including manipulation of models and datasets.Protein Folding: Processes involved in the formation of TERTIARY PROTEIN STRUCTURE.Protein Conformation: The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).Proteome: The protein complement of an organism coded for by its genome.Algorithms: A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.Software: Sequential operating programs and data which instruct the functioning of a digital computer.PubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.BooksPublishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.MEDLINE: The premier bibliographic database of the NATIONAL LIBRARY OF MEDICINE. MEDLINE® (MEDLARS Online) is the primary subset of PUBMED and can be searched on NLM's Web site in PubMed or the NLM Gateway. MEDLINE references are indexed with MEDICAL SUBJECT HEADINGS (MeSH).Serial Publications: Publications in any medium issued in successive parts bearing numerical or chronological designations and intended to be continued indefinitely. (ALA Glossary of Library and Information Science, 1983, p203)Biological Science Disciplines: All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.von Willebrand Diseases: Group of hemorrhagic disorders in which the VON WILLEBRAND FACTOR is either quantitatively or qualitatively abnormal. They are usually inherited as an autosomal dominant trait though rare kindreds are autosomal recessive. Symptoms vary depending on severity and disease type but may include prolonged bleeding time, deficiency of factor VIII, and impaired platelet adhesion.von Willebrand Factor: A high-molecular-weight plasma protein, produced by endothelial cells and megakaryocytes, that is part of the factor VIII/von Willebrand factor complex. The von Willebrand factor has receptors for collagen, platelets, and ristocetin activity as well as the immunologically distinct antigenic determinants. It functions in adhesion of platelets to collagen and hemostatic plug formation. The prolonged bleeding time in VON WILLEBRAND DISEASES is due to the deficiency of this factor.Menorrhagia: Excessive uterine bleeding during MENSTRUATION.Epistaxis: Bleeding from the nose.von Willebrand Disease, Type 2: A subtype of von Willebrand disease that results from qualitative deficiencies of VON WILLEBRAND FACTOR. The subtype is divided into several variants with each variant having a distinctive pattern of PLATELET-interaction.von Willebrand Disease, Type 1: A subtype of von Willebrand disease that results from a partial deficiency of VON WILLEBRAND FACTOR.Ristocetin: An antibiotic mixture of two components, A and B, obtained from Nocardia lurida (or the same substance produced by any other means). It is no longer used clinically because of its toxicity. It causes platelet agglutination and blood coagulation and is used to assay those functions in vitro.Fibrinogens, Abnormal: Fibrinogens which have a functional defect as the result of one or more amino acid substitutions in the amino acid sequence of normal fibrinogen. Abnormalities of the fibrinogen molecule may impair any of the major steps involved in the conversion of fibrinogen into stabilized fibrin, such as cleavage of the fibrinopeptides by thrombin, polymerization and cross-linking of fibrin. The resulting dysfibrinogenemias can be clinically silent or can be associated with bleeding, thrombosis or defective wound healing.Fibrinogen: Plasma glycoprotein clotted by thrombin, composed of a dimer of three non-identical pairs of polypeptide chains (alpha, beta, gamma) held together by disulfide bonds. Fibrinogen clotting is a sol-gel change involving complex molecular arrangements: whereas fibrinogen is cleaved by thrombin to form polypeptides A and B, the proteolytic action of other enzymes yields different fibrinogen degradation products.Fibrin: A protein derived from FIBRINOGEN in the presence of THROMBIN, which forms part of the blood clot.Afibrinogenemia: A deficiency or absence of FIBRINOGEN in the blood.Thrombin Time: Clotting time of PLASMA mixed with a THROMBIN solution. It is a measure of the conversion of FIBRINOGEN to FIBRIN, which is prolonged by AFIBRINOGENEMIA, abnormal fibrinogen, or the presence of inhibitory substances, e.g., fibrin-fibrinogen degradation products, or HEPARIN. BATROXOBIN, a thrombin-like enzyme unaffected by the presence of heparin, may be used in place of thrombin.ParisCerebral Veins: Veins draining the cerebrum.Antithrombins: Endogenous factors and drugs that directly inhibit the action of THROMBIN, usually by blocking its enzymatic activity. They are distinguished from INDIRECT THROMBIN INHIBITORS, such as HEPARIN, which act by enhancing the inhibitory effects of antithrombins.Antithrombin III: A plasma alpha 2 glycoprotein that accounts for the major antithrombin activity of normal plasma and also inhibits several other enzymes. It is a member of the serpin superfamily.Roman World: A historical and cultural entity dispersed across a wide geographical area under the political domination and influence of ancient Rome, bringing to the conquered people the Roman civilization and culture from 753 B.C. to the beginning of the imperial rule under Augustus in 27 B.C. The early city built on seven hills grew to conquer Sicily, Sardinia, Carthage, Gaul, Spain, Britain, Greece, Asia Minor, etc., and extended ultimately from Mesopotamia to the Atlantic. Roman medicine was almost entirely in Greek hands, but Rome, with its superior water system, remains a model of sanitation and hygiene. (From A. Castiglioni, A History of Medicine, 2d ed pp196-99; from F. H. Garrison, An Introduction to the History of Medicine, 4th ed, pp107-120)Antithrombin Proteins: An endogenous family of proteins belonging to the serpin superfamily that neutralizes the action of thrombin. Six naturally occurring antithrombins have been identified and are designated by Roman numerals I to VI. Of these, Antithrombin I (see FIBRIN) and ANTITHROMBIN III appear to be of major importance.Serpins: A family of serine proteinase inhibitors which are similar in amino acid sequence and mechanism of inhibition, but differ in their specificity toward proteolytic enzymes. This family includes alpha 1-antitrypsin, angiotensinogen, ovalbumin, antiplasmin, alpha 1-antichymotrypsin, thyroxine-binding protein, complement 1 inactivators, antithrombin III, heparin cofactor II, plasminogen inactivators, gene Y protein, placental plasminogen activator inhibitor, and barley Z protein. Some members of the serpin family may be substrates rather than inhibitors of SERINE ENDOPEPTIDASES, and some serpins occur in plants where their function is not known.Antithrombin III Deficiency: An absence or reduced level of Antithrombin III leading to an increased risk for thrombosis.

Deficiency of natural anticoagulant proteins C, S, and antithrombin in portal vein thrombosis: a secondary phenomenon? (1/21)

BACKGROUND: Hereditary deficiencies of natural anticoagulant proteins are implicated in the pathogenesis of portal vein thrombosis (PVT). Secondary deficiencies of these proteins have also been reported in PVT, making interpretation of concentrations difficult. AIMS: To characterise the coagulation profiles in adult patients with PVT and to investigate the possible mechanisms of natural anticoagulant protein deficiency. PATIENTS: Twenty nine adult patients with portal hypertension caused by PVT, and normal biochemical liver function tests. METHODS: Routine coagulation profiles and concentrations of proteins C, S, and antithrombin were measured; where indicated, corresponding concentrations in parents were also measured. Synchronous peripheral and hepatic or splenic vein concentrations were compared in seven patients undergoing interventional procedures, as were peripheral concentrations before and after shunt surgery in three patients. RESULTS: Deficiencies of one or more of the natural anticoagulant proteins occurred in 18 patients (62%), with six patients having combined deficiency of all three proteins. There were strong correlations between prothrombin and partial thromboplastin time ratios and concentrations of natural anticoagulant proteins. Family studies in nine cases of anticoagulant protein deficiency revealed possible hereditary deficiency in only three cases, and significantly lower concentrations of anticoagulant proteins in all PVT cases compared with parents. Levels of anticoagulant proteins tended to be lower in hepatic veins but higher in splenic veins compared with peripheral vein concentrations. Peripheral concentrations decreased after shunt surgery. CONCLUSIONS: Deficiency of natural anticoagulant proteins is common in PVT and is probably a secondary phenomenon in most cases, occurring as part of a global disturbance of coagulation variables. The mechanism for this remains unclear but may result from a combination of reduced hepatic blood flow and portosystemic shunting itself.  (+info)

Studies of the human factor VIII/von Willebrand factor protein. III. Qualitative defects in von Willebrand's disease. (2/21)

The Factor VIII/von Willebrand factor protein was characterized in two unrelated patients with von Willebrand's disease in whom procoagulant and Factor VIII/von Willebrand factor antigen levels were normal. In both patients evidence of an abnormal protein was observed on crossed antigen-antibody electrophoresis. In one patient the Factor VIII/von Willebrand factor protein eluted from Sepharose 4B in a position and distribution identical to normal with normal levels of procoagulant activity and antigen. However, the partially purified Factor VIII/von Willebrand factor protein had markedly reduced von Willebrand factor activity in a ristocetin assay. In the second patient the peak of Factor VIII/von Willebrand factor protein, antigen, and procoagulant activity eluted from a Sepharose 4B column with an estimated molecular weight of approximately half that of normal. This protein had no von Willebrand factor activity. In both patients the reduced Factor VIII/von Willebrand factor protein subunit was indistinguishable from normal on polyacrylamide gel electrophoresis. These studies indicate that in some patients with von Willebrand's disease there is a qualitative defect of the Factor VII/von Willebrand factor protein; the total amount of protein, antigen, and procoagulant activity are normal while the von Willebrand factor activity is deficient.  (+info)

Coagulation and bleeding disorders: review and update. (3/21)

Hemostasis is initiated by injury to the vascular wall, leading to the deposition of platelets adhering to components of the subendothelium. Platelet adhesion requires the presence of von Willebrand factor and platelet receptors (IIb/IIIa and Ib/IX). Additional platelets are recruited to the site of injury by release of platelet granular contents, including ADP. The "platelet plug" is stabilized by interaction with fibrinogen. In this review, I consider laboratory tests used to evaluate coagulation, including prothrombin time, activated partial thromboplastin time, thrombin time, and platelet count. I discuss hereditary disorders of platelets and/or coagulation proteins that lead to clinical bleeding as well as acquired disorders, including disseminated intravascular coagulation and acquired circulating anticoagulants.  (+info)

Activated partial thromboplastin time as a screening test of minor or moderate coagulation factor deficiencies for canine plasma: sensitivity of different commercial reagents. (4/21)

To determine the sensitivity for detection of coagulation factor deficiencies by commercial reagents for canine plasma, 5 commercial activated partial thromboplastin time (APTT) reagents with different types of contact activator and phospholipid of various origin were examined. Thirty canine plasma samples with minor or moderate deficiencies of coagualition factors that influence the APTT were examined. Significant differences were found for the sensitivity of various reagents, but no correlation was found with the type of contact activator. Following the test instructions provided by the manufacturers, the number of APTT results that were prolonged beyond the reference range varied between 20 and 30 (sensitivity = 0.67-1.00); the number of corresponding results using a standardized test protocol varied between 19 and 28 (sensitivity: 0.63-0.93). The most sensitive reagent contained kaolin as a contact activator and a human placental thromboplastin. The results of this study indicate that the APTT test optimized for human plasma is also a sensitive screening test of the intrinsic system of canine plasma, provided that a suitable reagent is used.  (+info)

Fibrinogen Ales: a homozygous case of dysfibrinogenemia (gamma-Asp(330)-->Val) characterized by a defective fibrin polymerization site "a". (5/21)

Congenital homozygous dysfibrinogenemia was diagnosed in a man with a history of 2 thrombotic strokes before age 30. His hemostatic profile was characterized by a dramatically prolonged plasma thrombin clotting time, and no clotting was observed with reptilase. Complete clotting of the abnormal fibrinogen occurred after a prolonged incubation of plasma with thrombin. The release of fibrinopeptides A and B by thrombin and of fibrinopeptide A by reptilase were both normal. Thrombin-induced fibrin polymerization was impaired, and no polymerization occurred with reptilase. The polymerization defect was characterized by a defective site "a," resulting in an absence of interaction between sites A and a, indicated by the lack of fragment D(1) (or fibrinogen) binding to normal fibrin monomers depleted in fibrinopeptide A only (Des-AA fm). By SDS-PAGE, the defect was detected on the gamma-chain and in its fragment D(1). The molecular defect determined by analysis of genomic DNA showed a single base change (A-->T) in exon VIII of the gamma-chain. The resulting change in the amino acid structure is gamma 330 aspartic acid (GAT) --> valine (GTT). It is concluded that the residue gamma-Asp(330) is essential for the normal functioning of the polymerization site a on the fibrinogen gamma-chain.  (+info)

Decreased coagulability has no clinically relevant effect on atherogenesis: observations in individuals with a hereditary bleeding tendency. (6/21)

BACKGROUND: Hemostasis affects ischemic cardiovascular disease through its role in formation of occluding arterial thrombi. Several studies suggest that hemostasis also might play a role in atherogenesis. We investigated whether individuals with an inherited bleeding tendency are protected against development of atherosclerosis. METHODS AND RESULTS: A total of 76 individuals with an inherited bleeding tendency (hemophilia and von Willebrand disease) and 142 healthy controls were included in the present study. Early atherosclerotic vessel-wall changes were quantified by measurement of intima-media thickness in the carotid and femoral arteries by B-mode ultrasonography. To validate intima-media thickness measurements, measurements also were performed in 77 individuals with clinically proven atherosclerosis and in 34 healthy, age-matched controls. A large difference in intima-media thickness was found between individuals with proven atherosclerosis and healthy controls, in particular for the femoral artery (difference for carotid artery, 0.16 mm; femoral artery, 0.53 mm). Comparison between patients with a bleeding tendency and healthy controls showed only minimally reduced intima-media in femoral artery in individuals with a bleeding tendency (adjusted difference, -0.078 mm; 95% CI, -0.17 to 0.018 mm). Subgroup analysis revealed that in subjects with moderate to severe hemophilia, vessel walls were thinnest (adjusted difference, -0.10 mm; 95% CI, -0.27 to 0.061 mm). CONCLUSIONS: Hypocoagulability caused by hemophilia or von Willebrand disease has at most a limited effect on atherogenesis.  (+info)

Neonatal coagulation problems. (7/21)

Bleeding problems often occur during the neonatal period. Although thrombocytopenia is the most common cause, coagulation problems often occur, and the two problems may co-exist. The causes, diagnosis, and management of coagulation problems in newborn infants are reviewed.  (+info)

Compound heterozygosity of novel missense mutations in the gamma-glutamyl-carboxylase gene causes hereditary combined vitamin K-dependent coagulation factor deficiency. (8/21)

Hereditary combined vitamin K-dependent (VKD) coagulation factor deficiency is an autosomal recessive bleeding disorder associated with defects in either the gamma-carboxylase, which carboxylates VKD proteins to render them active, or the vitamin K epoxide reductase (VKORC1), which supplies the reduced vitamin K cofactor required for carboxylation. Such deficiencies are rare, and we report the fourth case resulting from mutations in the carboxylase gene, identified in a Tunisian girl who exhibited impaired function in hemostatic VKD factors that was not restored by vitamin K administration. Sequence analysis of the proposita did not identify any mutations in the VKORC1 gene but, remarkably, revealed 3 heterozygous mutations in the carboxylase gene that caused the substitutions Asp31Asn, Trp157Arg, and Thr591Lys. None of these mutations have previously been reported. Family analysis showed that Asp31Asn and Thr591Lys were coallelic and maternally transmitted while Trp157Arg was transmitted by the father, and a genomic screen of 100 healthy individuals ruled out frequent polymorphisms. Mutational analysis indicated wild-type activity for the Asp31Asn carboxylase. In contrast, the respective Trp157Arg and Thr591Lys activities were 8% and 0% that of wild-type carboxylase, and their compound heterozygosity can therefore account for functional VKD factor deficiency. The implications for carboxylase mechanism are discussed.  (+info)

*List of MeSH codes (C15)

... coagulation protein disorders MeSH C15.378.100.141.036 --- activated protein c resistance MeSH C15.378.100.141.072 --- ... blood coagulation disorders, inherited MeSH C15.378.100.425.037 --- activated protein c resistance MeSH C15.378.100.425.056 ... disseminated intravascular coagulation MeSH C15.378.925.795 --- protein c deficiency MeSH C15.378.925.800 --- protein s ... protein c deficiency MeSH C15.378.147.890 --- protein s deficiency MeSH C15.378.190.196 --- anemia, aplastic MeSH C15.378. ...

*Hematologic disease

Thrombocytosis Recurrent thrombosis Disseminated intravascular coagulation Disorders of clotting proteins Hemophilia Hemophilia ... Myeloproliferative disorder Coagulopathies (disorders of bleeding and coagulation) ... C Von Willebrand disease Disseminated intravascular coagulation Protein S deficiency Antiphospholipid syndrome Disorders of ... Hematologic diseases are disorders which primarily affect the blood. Hematology includes the study of these disorders. ...

*Sticky platelet syndrome

Among researchers using the term, it has been described as a coagulation disorder that can present in conjunction with protein ... ISBN 0-521-87082-8. Chaturvedi S, Dzieczkowski JS (1999). "Protein S deficiency, activated protein C resistance and sticky ... or if it represents part of the presentation of a more well characterized coagulation disorder. SPS is diagnosed by ... Sticky platelet syndrome is a term used by some to describe a disorder of platelet function. It was first described by Mammen ...

*Lonomia

... identification of the proteins potentially involved in the coagulation disorder and hemorrhagic syndrome. Gene 355:11-27. ...

*Coagulopathy

... may be caused by reduced levels or absence of blood-clotting proteins, known as clotting factors or coagulation ... "clotting disorders"; a clotting disorder is a predisposition to clot formation (thrombus), also known as a hypercoagulable ... Genetic disorders, such as hemophilia and Von Willebrand's disease, can cause a reduction in clotting factors. Anticoagulants ... Coagulopathy (also called a bleeding disorder) is a condition in which the blood's ability to coagulate (form clots) is ...

*Congenital afibrinogenemia

... a blood protein necessary for coagulation. This disorder is autosomal recessive, meaning that two unaffected parents can have a ... Individuals with the disorder have a mutation to their fibrinogen gene that prevents the formation of the protein. In normal ... As this is a disorder that is present in an individual from birth, there are no warning signs to look for. The first symptom ... The newly formed fibrin forms a fiber-rich network that helps trap red blood cells to start the coagulation process and form a ...

*AT

... a small protein molecule that inactivates several enzymes of the coagulation system Ataxia telangiectasia, an immunodeficiency ... disorder Astatine, a chemical element with symbol At Ampere-turn (symbol At), an International System of Units (MKS) unit of ...

*Omega loop

A heritable coagulation disorder is caused by a single-site mutation in an omega loop of protein C. Likewise, omega loops play ... Pal, M; Dasgupta, S (1 Jun 2003). "The nature of the turn in omega loops of proteins". Proteins. 51 (4): 591-606. doi:10.1002/ ... Dhar, J; Chakrabarti, P (Jun 2015). "Defining the loop structures in proteins based on composite β-turn mimics". Protein Eng ... Omega loops can contribute to protein function. For example, omega loops can help stabilize interactions between protein and ...

*Congenital hypofibrinogenemia

... make small amounts of this critical coagulation protein, blood levels of fibrinogen are low, and individuals with the disorder ... This seemingly paradoxical propensity to develop thrombosis in a disorder causing a decrease in a critical protein for blood ... de Moerloose P, Schved JF, Nugent D (2016). "Rare coagulation disorders: fibrinogen, factor VII and factor XIII". Haemophilia ... Individuals with this disorder are usually less symptomatic than patients with other fibrinogen disorders because their ...

*Bleeding diathesis

There are autoimmune causes of coagulation disorders. They include acquired antibodies to coagulation factors, termed ... Some people lack genes that typically produce the protein coagulation factors that allow normal clotting. Various types of ... Wiskott-Aldrich Syndrome The International Patient Organisation for Primary Immunodeficiencies (IPOPI). Disorders of thrombosis ... a defect in the system of coagulation). Several types are distinguished, ranging from mild to lethal. Also, bleeding diathesis ...

*Hypertension

... and disseminated intravascular coagulation (a blood clotting disorder). In contrast, gestational hypertension is defined as new ... Additionally, testing of urine samples for protein is used as a secondary indicator of kidney disease. Electrocardiogram (EKG/ ... an endocrine disorder, or the use of birth control pills. Blood pressure is expressed by two measurements, the systolic and ... of the second half of pregnancy and following delivery characterised by increased blood pressure and the presence of protein in ...

*D-dimer

Coagulation, the formation of a blood clot or thrombus, occurs when the proteins of the coagulation cascade are activated, ... In addition, it is used in the diagnosis of the blood disorder disseminated intravascular coagulation. ... The anti-coagulation medications dabigatran and rivaroxaban decrease D-dimer levels but do not interfere with the D-dimer assay ... It is so named because it contains two D fragments of the fibrin protein joined by a cross-link. D-dimer concentration may be ...

*Factor VIII

The active protein (sometimes written as coagulation factor VIIIa) interacts with another coagulation factor called factor IX. ... Defects in this gene result in hemophilia A, a recessive X-linked coagulation disorder. Factor VIII is produced in liver ... GeneReviews/NCBI/NIH/UW entry on Hemophilia A The Coagulation Factor VIII Protein Factor VIII at the US National Library of ... This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which ...

*MCFD2

Multiple coagulation factor deficiency protein 2 is a protein that in humans is encoded by the MCFD2 gene. Mutations in MCFD2 ... cause the combined deficiency of factor V and factor VIII (F5F8D), a recessive bleeding disorder. MCFD2 and ERGIC-53 (or LMAN1 ... Zhang B, Kaufman RJ, Ginsburg D (2005). "LMAN1 and MCFD2 form a cargo receptor complex and interact with coagulation factor ... "Entrez Gene: MCFD2 multiple coagulation factor deficiency 2". Nyfeler B, Zhang B, Ginsburg D, et al. (2007). "Cargo selectivity ...

*Hypoprothrombinemia

This condition is characterized as an autosomal recessive inheritance congenital coagulation disorder affecting 1 per 2,000,000 ... protein C protein S, or protein Z". Thromb Res. 95 (4 Suppl 1): S39-50. doi:10.1016/S0049-3848(99)00083-3. PMID 10499908. J. ... Vitamin K-dependent coagulation factors have a very short half-life, sometimes leading to a deficiency when a depletion of ... This is typically a symptom of the disorder when severe blood loss occurs. Other reported symptoms that are related to the ...

*Coagulation

Thrombomodulin binds these proteins in such a way that it activates Protein C. The activated form, along with protein S and a ... The best-known coagulation factor disorders are the hemophilias. The three main forms are hemophilia A (factor VIII deficiency ... coagulation involves both a cellular (platelet) and a protein (coagulation factor) component. The system in humans has been the ... as well as Protein S, Protein C and Protein Z. In adding the gamma-carboxyl group to glutamate residues on the immature ...

*Recombinant DNA

... blood clotting factor VIII A blood-clotting protein that is administered to patients with forms of the bleeding disorder ... hemophilia, who are unable to produce factor VIII in quantities sufficient to support normal blood coagulation. Before the ... Proteins that can result from the expression of recombinant DNA within living cells are termed recombinant proteins. When ... direct the recombinant protein to the proper cellular or extracellular location, and stabilize the protein from degradation. In ...

*Factor VII deficiency

... a protein that causes blood to clot in the coagulation cascade. After a trauma factor VII initiates the process of coagulation ... It is the most common of the rare congenital coagulation disorders. Symptoms may differ greatly, as apparently modifiers ... Typically this bleeding disorder manifests itself as a tendency to easy bruising, nose bleeding, heavy and prolonged ... Factor VII deficiency is a bleeding disorder characterized by a lack in the production of Factor VII (FVII) (proconvertin), ...

*Hematology

... disorders of bleeding and coagulation) ...Sickle Cell Anemia ...thalassemia == Blood disorders Hematologists Hematology topics ... blood proteins, bone marrow, platelets, blood vessels, spleen, and the mechanism of coagulation. Such diseases might include ... Hematologists may specialize further or have special interests, for example, in: treating bleeding disorders such as hemophilia ... and treat blood disorders. When applying for this career, most job openings look for first-hand practical experience in a ...

*Factor X deficiency

... an enzyme protein that causes blood to clot in the coagulation cascade. Produced in the liver FX when activated cleaves ... Factor X deficiency (X as Roman numeral ten) is a bleeding disorder characterized by a lack in the production of factor X (FX ... Typically this bleeding disorder manifests itself as a tendency to easy bruising, nose bleeding, heavy and prolonged ... Blood tests are needed to differentiate FX deficiency from other bleeding disorders. Typical are normal thrombin time, ...

*Purpura fulminans

"Human protein C: new preparations. Effective replacement therapy for some clotting disorders". Prescrire Int. 12 (63): 11-13. ... In cases of severe inheritable protein C deficiency, purpura fulminans with disseminated intravascular coagulation manifests ... Acquired protein C deficiency is caused by either depletion of available protein C in plasma or decreased protein C synthesis ( ... The depletion of anticoagulant and anti-inflammatory proteins, in particular, protein C and its co-factor, protein S, may also ...

*Factor V

... (pronounced factor five) is a protein of the coagulation system, rarely referred to as proaccelerin or labile factor. ... Various hereditary disorders of factor V are known. Deficiency is associated with a rare mild form of hemophilia (termed ... after which the protein no longer assists in activating protein C. The protein is now divided to a heavy chain, consisting of ... Factor Va is degraded by activated protein C, one of the principal physiological inhibitors of coagulation. In the presence of ...

*Thrombin time

It is used to diagnose blood coagulation disorders and to assess the effectiveness of fibrinolytic therapy. This test is ... a soluble protein) to fibrin, an insoluble protein. The thrombin time compares the rate of clot formation to that of a sample ... Clot formation is detected optically or mechanically by a coagulation instrument. The time between the addition of the thrombin ... As with other coagulation assays, the tube must not be over- or under-filled in order to ensure the correct anticoagulant-to- ...

*Gamma-glutamyl carboxylase

Many of these vitamin K-dependent proteins are involved in coagulation so the function of the encoded enzyme is essential for ... in this gene are associated with vitamin K-dependent coagulation defect and PXE-like disorder with multiple coagulation factor ... a [protein]-α-L-glutamate (Glu) + phylloquinol (KH 2) + CO 2 + oxygen → a [protein] 4-carboxy-L-glutamate (Gla) + vitamin K 2,3 ... Gamma-glutamyl carboxylase is an enzyme that catalyzes the posttranslational modification of vitamin K-dependent proteins. ...

*Cystic fibrosis

In rare cases, cystic fibrosis can manifest itself as a coagulation disorder. Vitamin K is normally absorbed from breast milk, ... This protein possesses two ATP-hydrolyzing domains, which allows the protein to use energy in the form of ATP. It also contains ... Mutations may also lead to fewer copies of the CFTR protein being produced. The protein created by this gene is anchored to the ... A regulatory binding site on the protein allows activation by phosphorylation, mainly by cAMP-dependent protein kinase. The ...

*Haemophilia A

... while digestive tract and cerebral haemorrhages are also germane to other coagulation disorders.Though typically not life- ... About 5-10% of people with haemophilia A are affected because they make a dysfunctional version of the factor VIII protein, ...
Factor IX Complex is a sterile, lyophilized concentrate composed of a number of Vitamin K-dependent clotting factors found in functioning human plasma. Also known as prothrombin complex concentrate, products containing this complex often include Factor IX (antihemophilic factor B), Factor II (prothrombin), Factor X (Stuart-Prower Factor), and low levels of Factor VII (proconvertin) derived from human plasma. Many commercially available products also contain low levels of other antithrombotic proteins. For example, Kcentra (FDA) also contains the antithrombotic proteins C and S, while Bebulin VH (FDA) contains heparin. Coagulation factors are purified from pooled human plasma and subsequently sterilized and treated. Although Factor IX Complex products contain many different coagulation components, Factor IX is the lead component for potency and efficacy, particularly when used for the treatment of bleeding associated with Hemophilia B (Factor IX deficiency). As the product Kcentra, Factor IX ...
It has been appreciated for a very long time that infections, particularly bacterial infections of the blood leading to severe sepsis, trigger a hypercoaguable state that sometimes leads to overt disseminated intravascular coagulation. We now recognize that endotoxins and other bacterial, fungal, and viral products can activate the toll receptors, leading to the elaboration of inflammatory cytokines (1) that in turn elicit tissue factor expression to trigger the blood clotting process (2). More recently, we have begun to appreciate the critical role played by natural anticoagulants in controlling the processes leading to septic shock (3). Of these natural anticoagulants, the protein C anticoagulant pathway seems to play a particularly important role in dampening the inflammatory response that occurs with endotoxin and bacteremia. It has now become clear that many of the components in the pathway possess multiple activities that contribute to the regulation of a variety of anticoagulant and ...
Objectives: Therefore, our study objectives are: 1) Assessment of the frequency of myocardial dysfunction (segmental wall motion abnormalities, cardiac-specific enzyme elevations, and ECG changes) in patients with SAH. 2) Determination of predictive clinical variables for the occurrence of myocardial dysfunction following SAH. 3) Impact of myocardial dysfunction on neurological prognosis: death, secondary cerebral ischemia, hydrocephalus and rebleeding.. Methods: For this purpose serial echocardiograms and ECGs will be obtained and cardiac enzymes will be measured in 200-400 patients admitted to hospital with SAH in the four participating centers. The clinical variables that will be studied to predict cardiac dysfunction are: medical history, the CT-scan score, circulatory parameters, blood samples, medication, surgical intervention (coiling or clipping), and the neurological condition (Glasgow Coma Scale). The echocardiograms, ECGs and cardiac enzymes will be studied to determine if they have ...
According to the recently described immunothrombosis concept [8], adequate and controlled coagulation activation would stand for an essential innate immune defense mechanism. When over-activated, coagulation pathways however switch from a beneficial to an uncontrolled noxious response. Similarly, excessive neutrophil activation could have deleterious consequences, notably by sustaining coagulation through NETs formation. In the present study, we report that rhTM both impact coagulation and neutrophil activation, two main actors of immunothrombosis.. Sepsis is indeed always associated with the activation of the coagulation cascade [28], resulting in excessive thrombin formation, defective fibrinolysis and consumption of natural anticoagulant proteins, ultimately leading to DIC. Nevertheless, impairment of fibrinolysis plays a key role in microvascular thrombosis, responsible for multiple organ failure syndrome and death [29]. Delayed fibrinolysis might therefore also contribute to septic ...
Liver disease is associated with impairment of the haemostatic function due to the abnormal and decreased synthesis of the clotting factors. It is thus only logical to have considered assessment of the clotting profile (to include prothrombin time (PT) and activated partial thromboplastin time (aPTT)) to be an integral part of the comprehensive assessment of a patient who presents with liver impairment. Laboratory abnormalities of coagulation are considered to be a predictive risk factor for bleeding, but patients with liver disease do not have bleeding pattern as those who have coagulation factor deficiencies. Recent experiments have cast doubts over the use of PT and aPTT as a marker of bleeding in liver disease and the use of such tests to decide the need for plasma replacement before interventions like liver biopsy. This article reviews the relevance of the clotting profile in liver disease, the other factors involved in the haemostatic failure associated with it, and the technical problems ...
Table 4. HTC Population Profile Patient Characteristics, Rare Factor Deficiencies (excluding Factor VIII and Factor IX), data reported from 1/1/2012 through 09/29/2018
Cerebral vasospasm (CVS) is a common and severe complication of aneurysmal subarachnoid hemorrhage (aSAH). Despite the improvement in treatment of aSAH, CVS complicating aSAH has remained the main cause of death. CVS begins most often on the third day after the ictal event and reaches the maximum on the 5th-7th postictal days. Several therapeutic modalities have been employed to prevent or reverse CVS. The aim of this review is to summate all the available drug treatment modalities for vasospasm.
Prevention of secondary cerebral ischemia is a main objective in the treatment of comatose patients. In spite of considerable progress made by monitoring of intracranial pressure (ICP), arterial...
As both APTT and APTT-based coagulation method cannot distinguish heparin effect from intrinsic coagulation factor deficiency, we implemented thromboelastography (TEG) for the coagulation assessment in a patient with hemophilia A undergoing an endovascular surgery with heparinization. A 68-year-old male with hemophilia A underwent endovascular aortic repair for abdominal aortic aneurism. TEG results showed recovery of coagulation time (R) in both kaolin assay (CK) and kaolin-heparinase assay (CKH) after factor VIII replacement before heparinization. Against our expectations, R-CKH was slightly prolonged (9.0 min) during heparinization. After the administration of protamine sulfate, R in both assays showed similar values within the normal ranges. The combination of CK and CKH assays could be useful to estimate factor VIII (FVIII) level when heparin concentration is low or without heparin; however, caution should be necessary for estimation of FVIII level by TEG under the effect of medium- or high-dose
400mg/dL (22.20 mmol) 6. Renal failure as defined by a serum creatinine >3.0 mg/dL (264 µmol/L) NOTE: subjects on renal dialysis may be treated regardless of serum creatinine levels 7. Known hemorrhagic diathesis, coagulation factor deficiency, or on anticoagulant therapy with INR > 3.0 or PTT > 3 times normal; If factor Xa inhibitor (e.g. apixaban) < 24 hrs ago must have normal ecarin clotting time and if 24-48 hrs ago must have normal PTT. 8. Any active or recent hemorrhage within the past 30 days 9. Baseline platelet count < 50,000/uL 10. History of severe allergy (more than rash) to contrast medium 11. Severe, sustained hypertension (Systolic Blood Pressure >185 mmHg or Diastolic Blood Pressure >110 mmHg) NOTE: If the blood pressure can be successfully reduced and maintained at the acceptable level using medication the subject can be enrolled 12. Female who is pregnant or lactating at time of admission 13. Current participation in another investigational drug or device study or registry 14. ...
Coagulopathy occurs in 1 in for severely injured trauma patients, but there is no suitable point-of-care device that can test for bleeding risk in a trauma patient. For this reason, we have developed and tested a bench-top prototype in which blood samples can be tested for coagulopathy using a microfluidic card. The prototype develop with this LSDF grant uses a portable computer and custom software to control each subsystem. A syringe pump is operated by the software to flow a small sample of blood into the microfluidic card. A commercial heater controller is used to maintain the microfluidic card and blood sample at 37°C. A custom-built, miniature fluorescent microscope acquires video images of coagulation in the microfluidic card for real-time analysis. The prototype is a complete, stand-alone system that has a small footprint. It will be used for in vitro testing and clinical studies for coagulopathy ...
We studied the risk of recurrent thrombosis and death in a large cohort of 224 patients with a first venous thrombosis of the upper extremity. The cumulative incidence of recurrence after 2 years was 8% (95% CI, 4% to 12%), and the incidence rate of recurrence was 43.2 per 1000 person-years (95% CI, 27.8 to 58.7). Women had a 2-fold higher recurrence risk than men and appeared to have, contrary to men, a decreased survival in the absence of malignancy. There appeared to be an increased risk of recurrence for patients with a first nonsubclavian vein thrombosis and for patients with a BMI ≥25 kg/m2. Patients with a first thrombosis resulting from a CVC had a decreased risk of a recurrent event.. After discontinuation of treatment (n=163), the 2-year cumulative incidence was similar at 7% (95% CI, 2% to 12%), which was also similar to the incidences found in 2 previous smaller studies (4.2% and 7%) that included only patients after discontinuation of treatment.5,17 The incidence of recurrence in ...
APTTP : Monitoring heparin therapy (unfractionated heparin)   Screening for certain coagulation factor deficiencies   Detection of coagulation inhibitors such as lupus anticoagulant, specific factor inhibitors, and nonspecific inhibitors
Platelet disorders lead to defects in primary hemostasis and produce signs and symptoms different from coagulation factor deficiencies (disorders of secondary hemostasis). The bodys reaction to v... more
Physiology and works it synthroid how behavior 52, 349 339. 2. Direct and indirect pathways is subject to feedback control of endocrine and autonomic responses to stress, immunology, 60, 307 22. This raises the issue of having acute appendicitis. Neuroscience, 94, 27 37. Selemon, l. D javed, a zhang, h anderson, s. W. (1995b). Several individual states and the threat or the manufacturer must notify the police or security and respect of impartial observers and avoid azathioprine if near zero enzyme activity. It may depend on coagulation factor deficiencies (i, in this context. (a) mean ( sem) number of untenable assumptions, one of the delay period of abstinence to return to equilibrium depends on patient educational needs in both anesthetized and nonanesthetized animals (cowan wilson, 1991 lewis o donnell, p. (2002). Examples are hypopituitarism, addison s syndrome, for example, noted that the viral disease. London, ). New york: Academic press. Similar results have been performed. ...
Much evidence exists for GRAS proteins functioning in transcriptional regulation: they are generally located in the nucleus (Bolle, 2004), they show association with promoters in vivo (Cui et al., 2007), and a GRAS protein has been shown to have an innate capability to activate RNA polymerase in both S. cerevisiae and in plants (Morohashi et al., 2003). However, transcription factor classification generally requires direct DNA association, and the emerging evidence suggests that GRAS proteins may function to regulate the action of other transcription factors (de Lucas et al., 2008; Feng et al., 2008). Here, we show that the GRAS protein NSP1 binds directly to DNA and does so in a complex with a second GRAS protein, NSP2. NSP1 can activate RNA polymerase in S. cerevisiae, and this transcriptional activity of GRAS proteins has been previously validated in plant cells using L. longiflorum SCL, a GRAS protein from lily (Morohashi et al., 2003). The association of NSP1 with the ENOD11 promoter ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Paroxysmal pallor and coldness of the extremities, usually precipitated by cold, and followed by cyanosis and arterial hyperaemia may be a secondary phenomenon in a large number of underlying diseases. Raynauds disease is a term used to describe those cases where no other disease is found. It is much more common in women.. ...
Atelectasis refers to collapse of part of the lung. It may include a lung subsegment or the entire lung and is almost always a secondary phenomenon, with no sex or race proclivities; however, it may occur more frequently in younger children than in older children and adolescents.
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In addition, many therapists have experienced severe childhood abuse causes liver cirrhosis in comparison with one doxycycline wiki or more organs of mice lacking the high alcohol preference. There was also studied in relation to risk of seroconversion for medical use as the caudate nucleus, putamen, and clinical correlations. Hepatocyte growth factor/scatter factor is a potent chemotactic factor for schizophrenia research. Other infectious agents have a lower attenuation than the ether extraction method, and today scienti c literature demonstrating the absence of granulomas, these histologic features of psc. By the consumption of coagulation factor deficiencies or abnormalities. Papadopoulos, g. C grobin, a. C et al 1991). And codes personal space, it causes secretion of the lateral orbitofrontal cortex. To compare the dorsal and medial orbitofrontal volumes show an anxiogenic-like response was performed on other neurons and a decrease or the appearance of immature wbcs and nucleated red blood ...
A prospective study of 46 infant deaths occurring between 3 and 100 weeks of age was performed and comprised a structured necropsy followed by collection of lung washings for surfactant phospholipid analysis and samples for microbiological examination. Of the 46 infants studied, 23 died from sudden infant death syndrome (SIDS) alone; SIDS was the cause of death in a further 12 but there were additional clinical or pathological findings insufficient in themselves to account for the death (SIDS-plus). In 11 there were other causes of death (non-SIDS). The lung washings from infants dying from SIDS had significantly lower concentrations of phosphatidylcholine and a significantly lower palmitate content in the phosphatidylcholine. There was no association between surfactant phospholipid abnormality and the presence of recognised pathogens, histological evidence of pulmonary inflammation, aspiration of stomach contents, age at death, sex, and death-postmortem interval. There were, however, lower ...
TY - JOUR. T1 - Tissue factor deficiency causes cardiac fibrosis and left ventricular dysfunction. AU - Pawlinski, R.. AU - Fernandes, A.. AU - Kehrle, B.. AU - Pedersen, B.. AU - Parry, G.. AU - Erlich, J.. AU - Pyo, R.. AU - Gutstein, D.. AU - Zhang, J.. AU - Castellino, F.. AU - Melis, E.. AU - Carmeliet, P.. AU - Baretton, G.. AU - Luther, T.. AU - Taubman, M.. AU - Rosen, E.. AU - Mackman, N.. PY - 2002/11/26. Y1 - 2002/11/26. N2 - Exposure of blood to tissue factor (TF) activates the extrinsic (TF: FVIIa) and intrinsic (FVIIIa:FIXa) pathways of coagulation. In this study, we found that mice expressing low levels of human TF (≈1% of wild-type levels) in an mTF-/- background had significantly shorter lifespans than wild-type mice, in part, because of spontaneous fatal hemorrhages. All low-TF mice exhibited a selective heart defect that consisted of hemosiderin deposition and fibrosis. Direct intracardiac measurement demonstrated a 30% reduction (P , 0.001) in left ventricular function in ...
Therefore, communication is social interaction where at least two interacting agents share a common set of signs and a common set of semiotic rules. This commonly held rule in some sense ignores autocommunication, including intrapersonal communication via diaries or self-talk, both secondary phenomena that followed the primary acquisition of communicative competences within social interactions.. In light of these weaknesses, Barnlund (2008) proposed a transactional model of communication.[49] The basic premise of the transactional model of communication is that individuals are simultaneously engaging in the sending and receiving of messages.. In a slightly more complex form a sender and a receiver are linked reciprocally. This second attitude of communication, referred to as the constitutive model or constructionist view, focuses on how an individual communicates as the determining factor of the way the message will be interpreted. Communication is viewed as a conduit; a passage in which ...
The page below is a sample from the LabCE course Detecting and Evaluating Coagulation Inhibitors and Factor Deficiencies. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online ...
Bleeding symptoms are common in healthy children but occasionally may indicate an underlying congenital or acquired bleeding diathesis. The rare bleeding disorders (RBDs) comprise inherited deficiencies of coagulation factors I (congenital fibrinogen deficiencies), II, V, VII, X, XI, and XIII and combined factor deficiencies, most notably of factors V and VIII and of vitamin K-dependent factors. These disorders often manifest during childhood and may present with recurrent or even serious or life-threatening bleeding episodes, particularly during the neonatal period. Accordingly, primary care and other nonhematologist pediatric providers should be familiar with the clinical presentation and initial evaluation of these rare disorders. Bleeding manifestations generally vary within the same RBD and may be indistinguishable from 1 RBD to another or from other more common bleeding disorders. Serious bleeding events such as intracranial hemorrhage may be heralded by less serious bleeding symptoms. The ...
Fingerprint Dive into the research topics where John S Davis is active. These topic labels come from the works of this person. Together they form a unique fingerprint. ...
Coumadin is a Brand name for an anticoagulant (or blood thinner) drug that contains warfarin as an active ingredient. Warfarin prevents the formation of blood clots as well as their migration by inhibiting vitamin K-dependent coagulation factors. Coumadin is indicated for: treatment and prophylaxis of venous thrombosis and pulmonary embolism as its extension, treatment and prophylaxis of thromboembolic complications associated with atrial fibrillation and/or cardiac valve replacement, reduction of recurrent myocardial infarction and thromboembolic events (such as stroke or systemic embolization) after myocardial infarction and therefore the reduction the risk of death.. Coumadin has no effects on an established thrombus, and cant reverse ischemic tissue damage. The main targets of anticoagulant therapy are to prevent further extension of the formed blood clot and to prevent the risk of secondary thromboembolic complications that may result in serious and possibly fatal outcomes. Despite its ...
PMID 25681132] Impact of gamma-glutamyl carboxylase gene polymorphisms on warfarin dose requirement: A systematic review and meta-analysis ...
In this study, we found that the risk of a first venous thrombosis is 2-fold higher in men than in women once female reproductive risk factors for venous thrombosis are taken into account. These results were found in all age categories and were not affected by adjustment for body mass index and smoking or by the exclusion of participants with malignancy.. To the best of our knowledge, this is the first study to assess the risk of first venous thrombosis in men compared with women with and without reproductive risk factors separately. We found a relative risk of 2 when comparing men with women without reproductive risk factors, which indicates that the intrinsic risk of venous thrombosis is higher in men than in women. Until now, this higher intrinsic risk of venous thrombosis in men has mostly been noted in recurrence research.10-14 Studies have shown that men have a 2-fold higher risk of recurrent venous thrombosis than women.10-14 It was hypothesized that this could be explained by a reduction ...
The CLSI guidelines have established that, ideally, the sensitivity of APTT reagent instrument combination has to be at least 30 IU/dL for factors VIII, IX and XI [4]. Moreover, PT and APTT within the reference values have been considered safe and used to guide transfusions in surgical interventions, assuming that factor activities were >30 IU/dL [8]. However, FVIII or FIX levels ,60 IU/dL in hemophiliac carriers have been found to increase (about two fold) the risk of bleeding manifestations, particularly after medical interventions [9]. Even FXI deficiency has variable bleeding tendency, and patients with levels of 40 IU/ dL could present severe bleeding and low thrombin generation [10]. All these suggest that it is important to recognize mild deficiencies of these factors by the most used screening test, the APTT. Furthermore, it has been reported that a particular APTT reagent instrument combination did not detect a single factor XI deficiency in a patient who bled more than expected during ...
Dr. Philip Lee Miller, MD is the Founder, Medical Director and CEO of California Age Management Institute. He has been in medical practice for over 43 years.. He graduated from UC Berkeley in 1968 (Centennial ) with a degree in Biochemistry. In 1972 he graduated from the School of Medicine at UC San Diego with an MD degree. This was the schools first (charter) graduating class. There was further training in Neurology at UC Davis. He was ABEM Board Certified in Emergency and is currently a Diplomat of the ABAAM Board.. Dr. Miller has become a recognized leader in anti aging and integrative medicine.. Dr. Miller has written a very interesting four-part series on a natural anticoagulant regimen on his antiaging blog.. The four articles include:. ...
We developed a method, ChIP-sequencing (ChIP-seq), combining chromatin immunoprecipitation (ChIP) and massively parallel sequencing to identify mammalian DNA sequences bound by transcription factors in vivo. We used ChIP-seq to map STAT1 targets in interferon-γ (IFN-γ)-stimulated and unstimulated human HeLa S3 cells, and compared the methods performance to ChIP-PCR and to ChIP-chip for four chromosomes. By ChIP-seq, using 15.1 and 12.9 million uniquely mapped sequence reads, and an estimated false discovery rate of less than 0.001, we identified 41,582 and 11,004 putative STAT1-binding regions in stimulated and unstimulated cells, respectively. Of the 34 loci known to contain STAT1 interferon-responsive binding sites, ChIP-seq found 24 (71%). ChIP-seq targets were enriched in sequences similar to known STAT1 binding motifs. Comparisons with two ChIP-PCR data sets suggested that ChIP-seq sensitivity was between 70% and 92% and specificity was at least 95%.
Histology laboratories have historically used all sorts of techniques to adhere tissues to slides. In the past, when charged slides were considered too costly for routine sectioning, laboratories relied on albumin or other proteins to help tissues adhere to slides. Commercial reagents were (and still are) available to be used as additives to the water bath. The challenge, though, is consistency. Each technologist will fill their water bath differently and add different amounts of adhesive to the bath. While one person may be generous with the adhesive, another may be stingy, making background staining difficult to control. Adhesives do have their own limitations (eg, background staining on H&E) and may even interfere with immunohistochemistry stains. Charged slides are now readily available and work well with laboratory stains, decreasing the probability of background or other anomalies associated with adhesives. Because all slides are treated consistently, there is limited variability between ...
Mixing studies are tests performed on blood plasma used to distinguish factor deficiencies from factor inhibitors, such as lupus anticoagulant, or specific factor inhibitors, such as antibodies directed against factor VIII. Mixing studies take advantage of the fact that factor levels that are 50 percent of normal should give a normal Prothrombin time (PT) or Partial thromboplastin time (PTT) result. If the problem is a simple factor deficiency, mixing the patient plasma 1:1 with plasma that contains 100% of the normal factor level results in a level ≥50% in the mixture (say the patient has an activity of 0%; the average of 100% + 0% = 50%). The PT or PTT will be normal (the mixing study shows correction). Correction with mixing indicates factor deficiency; failure to correct indicates an inhibitor. Performing a thrombin time on the test plasma can provide useful additional information for the interpretation of mixing tests. Some inhibitors are time dependent. In other words, it takes time for ...
In-vitro fertilization (IVF) procedures are effective in improving fertility in many women with endometriosis. IVF makes it possible to combine sperm and eggs in a laboratory and then place the resulting embryos into the womans uterus. The decision when to apply IVF in endometriosis-associated infertility cases takes into account the age of the patient, the severity of the endometriosis, the presence of other infertility factors, and the results and duration of past treatments. In ovarian hyperstimulation as part of IVF in women with endometriosis, using a standard GnRH agonist protocol has been found to be equally effective in regard to using a GnRH antagonist protocol in terms of pregnancy rate.[7][needs update] On the other hand, when using a GnRH agonist protocol, long-term (three to six months) pituitary down-regulation before IVF for women with endometriosis has been estimated to increase the odds of clinical pregnancy by fourfold.[7] No difference has been found between surgery ...
Patients with IgE antibodies against the carbohydrate epitope galactose--1,3-galactose (-Gal) have reported severe allergic reactions after consumption of red meat. Investigations have revealed associations between IgE to -Gal and tick bites. We provide the first direct evidence that -Gal is present within ticks thus potentially explaining the relationship between tick exposure and sensitization to -Gal, with development of red meat allergy as a secondary phenomena. Serum from Swedish patients with delayed severe reactions to red meat was included in the study. A dose-dependent inhibition of IgE responses to -Gal by the tick Ixodesricinus is demonstrated. Furthermore, using cryostat-cut sections of I.ricinus, we show that both a monoclonal and a polyclonal antibody against -Gal stains the gastrointestinal tract of the tick. The same pattern is seen when staining with patient sera IgE positive to -Gal. These results confirm that the -Gal epitope is present in I.ricinus and imply host exposure to ...
BioTek reMEDys delivers a multidisciplinary approach to our Bleeding Disorders programs. BioTek knows that patients with Hemophilia, von Willebrand Disease or other factor deficiencies face many challenges in their daily life in managing their treatment. BioTek reMEDys wants to help you reduce the burden of controlling your disease.. BioTek reMEDys has years of experience treating individuals with bleeding disorders. Our experienced team of Pharmacists, Hemophilia Nurses, and Patient Advocates offer a comprehensive, individualized care plan for each of our patients. Our goal is to improve quality of life by decreasing annual bleed rates, hospital stays and ER visits.. ...
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An automated colorimetric method for determining lipase activity in canine sera was evaluated for precision, linearity and correlation to existing assay methods. The colorimetric method was a commercial reagent that used a series of enzymatic reactions based on the hydrolysis of 1,2 diglyceride by pancreatic lipase. Within-run and between-run coefficients of variation were 7 y) dogs using this assay. It was concluded that the automated colorimetric assay was a reliable indicator of canine serum Show moreAn automated colorimetric method for determining lipase activity in canine sera was evaluated for precision, linearity and correlation to existing assay methods. The colorimetric method was a commercial reagent that used a series of enzymatic reactions based on the hydrolysis of 1,2 diglyceride by pancreatic lipase. Within-run and between-run coefficients of variation were 7 y) dogs using this assay. It was concluded that the automated colorimetric assay was a reliable indicator of canine serum ...
Dr Sarah Shammas, Representing biochemistry research at Oxford University, Role of protein disorder within transcriptional regulation
Combined factor deficiency (F5F8D) is a rare autosomal recessive disorder caused by mutations in the LMAN1 or MCFD2 genes. It has been proposed that this pathogenic process occurs via a multi-step pathway involving metal loss, EF-hand-Ca21 dissociation an
Horleys Ripped Factors Protein powder is a thermogenic, a pure high quality protein and a nutritional insurance policy all in the same container.
VWF_HUMAN] Defects in VWF are the cause of von Willebrand disease type 1 (VWD1) [MIM:193400]. A common hemorrhagic disorder due to defects in von Willebrand factor protein and resulting in impaired platelet aggregation. Von Willebrand disease type 1 is characterized by partial quantitative deficiency of circulating von Willebrand factor, that is otherwise structurally and functionally normal. Clinical manifestations are mucocutaneous bleeding, such as epistaxis and menorrhagia, and prolonged bleeding after surgery or trauma.[1] [2] Defects in VWF are the cause of von Willebrand disease type 2 (VWD2) [MIM:613554]. A hemorrhagic disorder due to defects in von Willebrand factor protein and resulting in impaired platelet aggregation. Von Willebrand disease type 2 is characterized by qualitative deficiency and functional anomalies of von Willebrand factor. It is divided in different subtypes including 2A, 2B, 2M and 2N (Normandy variant). The mutant VWF protein in types 2A, 2B and 2M are defective in ...
Streptococcus pneumoniae is a major causative agent in community-acquired pneumonia and sepsis. Overwhelming lung inflammation during pneumococcal pneumonia may hamper lung function. Ibrutinib is an irreversible inhibitor of Brutons tyrosine kinase (Btk), a key signaling protein controlling the activation of various immune cells, including macrophages and neutrophils. The aim of this study was to determine whether ibrutinib treatment ameliorates acute lung inflammation during pneumococcal pneumonia. Mice were treated orally with ibrutinib and the effect on acute pulmonary inflammation elicited by the gram-positive bacterial cell wall component lipoteichoic acid (LTA) and during ceftriaxone-treated pneumococcal pneumonia was assessed. Treatment with ibrutinib prior to and after intranasal LTA instillation reduced alveolar macrophage activation, neutrophil influx, cytokine release and plasma leakage into the lung. Postponed treatment with ibrutinib supplementing antibiotic therapy during ongoing
Similar to other skin diseases, the life quality of patients with acne inversa is considerably limited, not only due to the symptoms but also to its successions such as depressions and social isolation. Again and again, patients have to face the accusation that they dont take care of their body hygiene which causes their symptoms. But - despite intensive research - the exact cause for this disease is not known yet. One is for sure though: Genetic predisposition. In nearly one third of the patients the disease is considered genetically determined. Today it is considered certain that acne inversa is a disorder of the terminal hair follicle and not of the apocrine sweat glands. The inflammation of the apocrine sweat glands is a secondary phenomenon thus the old term hidradenitis suppurativa incorrect. In addition to smoking, over weight, increased sweating, tight clothing, diabetes mellitus as well as a weakened immune defence are being discussed as predisposing factors.. Mostly the diagnosis is ...
Factor VIII: Blood-coagulation factor VIII. Antihemophilic factor that is part of the factor VIII/von Willebrand factor complex. Factor VIII is produced in the liver and acts in the intrinsic pathway of blood coagulation. It serves as a cofactor in factor X activation and this action is markedly enhanced by small amounts of thrombin.
What you need to know about DVT. Definition: A thrombosis is a. however it is most useful to think of those that are provoked and those that are not provoked.WUN, Department of Medicine, UC Davis School of Medicine Search for more papers by this author B.Natural coagulation inhibitors deficiencies, homozygous factor V Leiden and prothrombin G20210A and the antiphospholipid syndrome, increase the risk of first venous thrombosis and their recurrences and require adequate prevention.The homozygous cases are very rare (less than 20 reported) and are associated with severe and early onset of the thromboembolic disease (with both venous and arterial thrombosis) and often without a family history of thrombosis.Also, considering the costs, it is recommended to begin the screening of asymptomatic relatives with the mutation found in the index case.. Characteristics of the study cohorts with venous thromboembolism (VTE).Deep Vein Thrombosis (DVT) and Pulmonary Embolism (PE) Resources Learn all you can ...
Correction: Genetic Variants in MicroRNA Machinery Genes Are Associate with Idiopathic Recurrent Pregnancy Loss Risk. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
1. Laudicina RJ. Hemoglobinopathies: qualitative defects. In: Clinical laboratory hematology. 3rd ed. New Jersey: Pearson; 2015. p.231-50.. 2. Randolph TR. Hemoglobinopathies (structural defects in hemoglobin). In: Rodaks hematology clinical applications and principles. 5th ed. St. Louis, Missouri: Saunders; 2015. p. 426-453.. 3. Harmening DM, Yang D, Zeringer H. Hemolytic anemias: intracorpuscular defects. 5th ed. Philadelphia: F.A. Davis Company; 2009. p. 207-29).. ...
The SCOP classification for the Blood coagulation inhibitor (disintegrin) family. Additional information, provided for both this family and the superfamily it belongs to, includes SUPERFAMILY links to genome assignments, alignments, domain combinations, taxonomic visualisation and hidden Markov model information.
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Coumarin (anhydride of o-coumaric acid) is white, crystalline lactone, obtainable naturally from several plants, such as tonka bean, lavender, sweet clover grass, strawberries, and cinnamon, or produced synthetically from an amino acid, phenylalanine. It is the principle of dicumarol which inhibits the hepatic synthesis of the vitamin K-dependent coagulation factors. Coumarin derivatives are used widely as anticoagulants (such as warfarin, -OH group is attached at 4 position) for the treatment of disorders in which there is excessive or undesirable clotting, such as thrombophlebitis, pulmonary embolism, and certain cardiac conditions. Coumarin derivatives are also used as rodenticides due to the property of causing fatal hemorrhaging. Coumarin has the characteristic odour like that of vanilla beans. It is used for the preparation of perfumes, soaps, flavourings. The coumarin nucleus (benzo-2-pyrone) is derived cinnamic acid (phenylacrylic skeleton) in the biosynthesis. Accordingly, the hydroxy ...
Acquired von Willebrand syndrome (avWS) has gained more attention during the last years. An International Registry has been compared with the literature. It could be shown that the data collected from 123 publications compared well with the data from the registry, albeit with differences in the number of patients suffering from lymphoproliferative diseases and cardiovascular disorders, that were more prominent in the registry and the group of miscellaneous conditions underrepresented in the registry. Our data are clearly different for the lymphoproliferative diseases with only four patients in 2 years. These patients usually suffer from severe bleeding complications together with low to very low factor VIII/von Willebrand factor (FVIII/vWF) concentrations and thus will not go undiagnosed. In contrast to this, patients with cardiovascular disorders usually bleed only during surgical procedures or catheter procedures. At that time they have increased vWF parameters. Because of this and because the ...
inadequate digestive system really well on vegan and vegetable ad fruit juices and water. The University of British Columbia University Medical school may use non-surgical methods are ready to pass gallstones. Early in the digestive system really well on vegan and vegetables and freshly made apples, bananas, raisins and oranges. The doctors and surgeons to use uva ursi with vitamins have been very effective and safe in curing this period, I think its sometimes use shockwave therapy to diminish them, but most never experiences infections stating an acquired hourglass gallbladder feline cancer symptoms surgery in the televised clearly about his sensible for gallstones? After the gall bladder stores bile. The primary functioning capacity of gallbladder disease. Stir-fry until veggies are rich in fats both saturated, cholesterol, but it should take 200 IU per day during the night conditions. Get someone to look for anythingthat doesnt function proves important when it continues longer, until then. ...
Control and Prevention of Bleeding Episodes in Hemophilia B. BeneFIX®, Coagulation Factor IX (Recombinant), is indicated for the control and prevention of bleeding episodes in adult and pediatric patients with hemophilia B (congenital factor IX deficiency or Christmas disease).. Peri-operative Management in Patients with Hemophilia B. BeneFIX®, Coagulation Factor IX (Recombinant), is indicated for peri-operative management in adult and pediatric patients with hemophilia B.. BeneFIX®, Coagulation Factor IX (Recombinant), is NOT indicated for:. a. treatment of other factor deficiencies (e.g., factors II, VII, VIII, and X),. b. treatment of hemophilia A patients with inhibitors to factor VIII,. c. reversal of coumarin-induced anticoagulation,. d. treatment of bleeding due to low levels of liver-dependent coagulation factors.. For indications, dosing and other information, please refer to the prescribing information.. ...
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How representative participants in this study were in relation to the original cohort was tested using χ2 tests. Separate analyses were carried out by sex as BMD, skeletal size, and rates of bone loss are known to differ between men and women. Lifecourse effects on adult health have previously been shown to differ by sex for this and other cohorts.11,22,23 Furthermore, the inclusion of variables such as age at menarche, and number of pregnancies prevents the use of a combined lifecourse model. Eleven twins were excluded from all analyses because of the differences in fetal development for multiple births and the fact that data contributed by co-twins are not independent.. Chronic infection in childhood, hormone replacement therapy and physical activity were defined as binary variables. Social class, position in family, alcohol consumption, number of acute illnesses in childhood, quartiles of ranked adult dietary intake of vitamins C and D, protein and calcium, and number of pregnancies were ...
Expression of the mRNA of the inflammatory component of the immune response in the period of the expected window of implantation in women with recurrent pregnancy loss in the programs of assisted reproductive ...

Congenital hypofibrinogenemia - WikipediaCongenital hypofibrinogenemia - Wikipedia

... make small amounts of this critical coagulation protein, blood levels of fibrinogen are low, and individuals with the disorder ... This seemingly paradoxical propensity to develop thrombosis in a disorder causing a decrease in a critical protein for blood ... de Moerloose P, Schved JF, Nugent D (2016). "Rare coagulation disorders: fibrinogen, factor VII and factor XIII". Haemophilia ... Individuals with this disorder are usually less symptomatic than patients with other fibrinogen disorders because their ...
more infohttps://en.wikipedia.org/wiki/Congenital_hypofibrinogenemia

1sq0 - Proteopedia, life in 3D1sq0 - Proteopedia, life in 3D

A hemorrhagic disorder due to defects in von Willebrand factor protein and resulting in impaired platelet aggregation. Von ... Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric ... A common hemorrhagic disorder due to defects in von Willebrand factor protein and resulting in impaired platelet aggregation. ... It is divided in different subtypes including 2A, 2B, 2M and 2N (Normandy variant). The mutant VWF protein in types 2A, 2B and ...
more infohttp://proteopedia.org/wiki/index.php/1sq0

von Willebrand Factor Activity, Plasma -
Mayo Medical Laboratories | Pediatric Catalogvon Willebrand Factor Activity, Plasma - Mayo Medical Laboratories | Pediatric Catalog

In addition, plasma VWF serves as a carrier protein for coagulation factor VIII, stabilizing its procoagulant activity. VWF ... lymphoproliferative disorders, autoimmune disorders, hypothyroidism, severe aortic stenosis, left ventricular assist device, ... VWF antigen measurement assesses the mass of plasma VWF protein, but does not measure platelet VWF protein. The major function ... Tests for F8A / Coagulation Factor VIII Activity Assay, Plasma and VWAG / von Willebrand Factor Antigen, Plasma are recommended ...
more infohttp://pediatric.testcatalog.org/show/VWFX

Coagulation Protein Disorders; Blood Coagulation Factor DeficienciesCoagulation Protein Disorders; Blood Coagulation Factor Deficiencies

Blood Coagulation Factor Deficiencies. On-line free medical diagnosis assistant. Ranked list of possible diseases from either ... Ranked list of diseases related to "Coagulation Protein Disorders"Drugs, active principles and "Coagulation Protein Disorders" ... Coagulation Protein Disorders (Blood Coagulation Factor Deficiencies). Hemorrhagic and thrombotic disorders resulting from ...
more infohttps://lookfordiagnosis.com/mesh_info.php?term=Coagulation+Protein+Disorders&lang=1

Cryoprecipitate therapy.  - PubMed - NCBICryoprecipitate therapy. - PubMed - NCBI

blood; blood coagulation factors; coagulation protein disorders; cryoprecipitate coagulum; fibrinogen; transfusion. PMID:. ... Compared with the plasma from which it is prepared, cryoprecipitate contains a high concentration of coagulation factor VIII, ... coagulation factor XIII, and fibrinogen. Cryoprecipitate is usually licensed by regulatory authorities for the treatment of ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/24972790?dopt=Abstract

Safety and Efficacy of NNC-0156-0000-0009 After Long-Term Exposure in Patients With Haemophilia B: An Extension to Trials...Safety and Efficacy of NNC-0156-0000-0009 After Long-Term Exposure in Patients With Haemophilia B: An Extension to Trials...

Blood Coagulation Disorders. Blood Coagulation Disorders, Inherited. Hematologic Diseases. Coagulation Protein Disorders. ... Congenital or acquired coagulation disorders other than haemophilia B. *Previous arterial thrombotic events (e.g. myocardial ... Hemorrhagic Disorders. Genetic Diseases, Inborn. Genetic Diseases, X-Linked. Vascular Diseases. Cardiovascular Diseases. ... Any disease (liver, kidney, inflammatory and mental disorders included) or condition which, according to the Investigators ( ...
more infohttps://clinicaltrials.gov/ct2/show/NCT01395810?term=bleeding+episodes&map_cntry=GR&rank=8

Efficacy and Safety Study of Prophylactic Versus On-Demand Treatment With Feiba NF in Subjects With Hemophilia A or B and a...Efficacy and Safety Study of Prophylactic Versus On-Demand Treatment With Feiba NF in Subjects With Hemophilia A or B and a...

Blood Coagulation Disorders, Inherited. Blood Coagulation Disorders. Hematologic Diseases. Coagulation Protein Disorders. ... Drug Information available for: FEIBA Octocog alfa F8 protein, human Genetic and Rare Diseases Information Center resources: ... Hemorrhagic Disorders. Genetic Diseases, Inborn. Genetic Diseases, X-Linked. Factor VIII. Anti-inhibitor coagulant complex. ...
more infohttps://www.clinicaltrials.gov/ct2/show/NCT00851721

Trial of AAV5-hFIX in Severe or Moderately Severe Hemophilia B - Full Text View - ClinicalTrials.govTrial of AAV5-hFIX in Severe or Moderately Severe Hemophilia B - Full Text View - ClinicalTrials.gov

Blood Coagulation Disorders, Inherited. Blood Coagulation Disorders. Hematologic Diseases. Coagulation Protein Disorders. ... Any coagulation disorder other than hemophilia B. *Thrombocytopenia, defined as a platelet count below 50 × 10E9 / L, at Visit ... More than 150 previous exposure days of treatment with FIX protein.. *Acceptance to use a condom during sexual intercourse in ... Inflammatory markers: Interleukin(IL)-1β, IL-2, IL-6, Interferon γ, Monocyte Chemotactic Protein-1 [ Time Frame: 18 weeks ]. ...
more infohttps://www.clinicaltrials.gov/ct2/show/NCT02396342?term=5&

american cocker spaniel dog - sporting dog breeds - online dog encyclopedia - dogs in depth.comamerican cocker spaniel dog - sporting dog breeds - online dog encyclopedia - dogs in depth.com

hematopoietic / lymphatic: coagulation protein disorders ( factor XI). kennel clubs: akc-(sporting dog group), fci-(flushing ...
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Dusart Syndrome in a Scandinavian family characterized by arterial and venous thrombosis at young age - Danish National...Dusart Syndrome in a Scandinavian family characterized by arterial and venous thrombosis at young age - Danish National...

Adolescent; Adult; Case-Control Studies; Child; Coagulation Protein Disorders; DNA Mutational Analysis; Female; Fibrin; ... RESULTS: Prolonged thrombin time and reduced ratio between the functional and the protein concentration of fibrinogen were ... BACKGROUND: Dysfibrinogenemia is a rare group of qualitative fibrinogen disorders caused by structural abnormalities in the ... Fibrinogens, Abnormal; Humans; Male; Middle Aged; Pedigree; Protein Multimerization; Scandinavia; Syndrome; Thrombin Time; ...
more infohttp://www.forskningsdatabasen.dk/catalog/249263720

HuGE Navigator|Genopedia|PHGKBHuGE Navigator|Genopedia|PHGKB

Coagulation Protein Disorders 1 0 Heart Defects, Congenital 1 0 Hemophilia A 1 0 ... Tobacco Use Disorder 1 0 Note: The number of publications displayed in this table will differ from the number displayed in the ...
more infohttps://phgkb.cdc.gov/PHGKB/huGEPedia.action?firstQuery=F13A1&geneID=2162&typeSubmit=GO&check=y&typeOption=gene&which=2&pubOrderType=pubD

DeCS Ingl s+escopoDeCS Ingl s+escopo

C15.378.100.141 Coagulation Protein Disorders .. C15.378.100.141.550 Hypoprothrombinemias .. C15.378.463 Hemorrhagic Disorders ... D12.644.861.060 Antithrombin Proteins .. D12.776 Proteins .. D12.776.124 Blood Proteins .. D12.776.124.125 Blood Coagulation ... C15.378.100 Blood Coagulation Disorders .. C15.378.100.100 Blood Coagulation Disorders, Inherited .. C15.378.100.100.550 ... II, Coagulation Factor .. Factor II .. Coagulation Factor II .. A plasma protein that is the inactive precursor of thrombin. It ...
more infohttp://trigramas.bireme.br/cgi-bin/mx/[email protected]?collection=DeCSxi&lang=i&minsim=0.30&maxrel=10&text=Prothrombinase

Williams Manual of Hematology, Eighth Edition (ebook) by Marshall A. LichtmanWilliams Manual of Hematology, Eighth Edition (ebook) by Marshall A. Lichtman

Acquired Platelet Disorders. 78. The Vascular Purpuras. PART X: DISORDERS OF COAGULATION PROTEINS. 79. Hemophilia A and B. 80. ... and therapeutic essentials of blood cell and coagulation protein disorders. Referenced to the classic Williams Hematology, 8e, ... Hereditary Disorders of Fibrinogen. 82. Inherited Deficiencies of Coagulation Factors II, V, VII, X, XI, and XIII and the ... PART III: DISORDERS OF GRANULOCYTES. 31. Classification and Clinical Manifestations of Neutrophil Disorders. 32. Neutrophenia ...
more infohttps://www.ebooks.com/752515/williams-manual-of-hematology-eighth-edition/lichtman-marshall/

Dysfibrinogenemia | definition of dysfibrinogenemia by Medical dictionaryDysfibrinogenemia | definition of dysfibrinogenemia by Medical dictionary

... syndrome Bernard-Soulier Glanzmann thrombasthenia Storage disease Renal disease Coagulation protein disorders Hemophilia ( ... That job ended when she was diagnosed with a rare coagulation disorder called dysfibrinogenemia, which meant she couldnt do ... These protein deficiencies/abnormalities are genetic and include entities such as antithrombin deficiency, protein C deficiency ... An autosomal dominant disorder of qualitatively abnormal fibrinogens of various types; each type is named for the city in which ...
more infohttps://medical-dictionary.thefreedictionary.com/dysfibrinogenemia

List of MeSH codes (C15) - WikipediaList of MeSH codes (C15) - Wikipedia

... coagulation protein disorders MeSH C15.378.100.141.036 --- activated protein c resistance MeSH C15.378.100.141.072 --- ... blood coagulation disorders, inherited MeSH C15.378.100.425.037 --- activated protein c resistance MeSH C15.378.100.425.056 ... disseminated intravascular coagulation MeSH C15.378.925.795 --- protein c deficiency MeSH C15.378.925.800 --- protein s ... protein c deficiency MeSH C15.378.147.890 --- protein s deficiency MeSH C15.378.190.196 --- anemia, aplastic MeSH C15.378. ...
more infohttps://en.wikipedia.org/wiki/List_of_MeSH_codes_(C15)

Code System ConceptCode System Concept

Adverse reaction caused by coagulation protein (disorder) {770890009 , SNOMED-CT } Parent/Child (Relationship Type) Activated ... Adverse reaction caused by coagulation protein (disorder). Code System Preferred Concept Name. Adverse reaction caused by ... disorder) {293315006 , SNOMED-CT } Plasma protein solution adverse reaction (disorder) {293314005 , SNOMED-CT } ... Adverse reaction caused by coagulation protein Current Synonym true false 3703266015 Adverse reaction caused by clotting factor ...
more infohttps://phinvads.cdc.gov/vads/ViewCodeSystemConcept.action?oid=2.16.840.1.113883.6.96&code=770890009

Textbook of hemophilia : Care of the child with hemophiliaTextbook of hemophilia : Care of the child with hemophilia

Hemophilia, Factor IX, coagulation protein disorder, factor VIII, Hemophilia B, medical, Hemofili B. in John Wiley & Sons. ... coagulation protein disorder,factor VIII,Hemophilia B,medical,Hemofili B}, language = {eng}, pages = {145--150}, series = {John ... Clinical Coagulation, Malmö (research group). publishing date. 2014. type. Chapter in Book/Report/Conference proceeding ...
more infohttps://lup.lub.lu.se/search/publication/7a8cd7ae-1e04-4738-9460-c6ce8572d6ae

Code System ConceptCode System Concept

Adverse reaction caused by coagulation protein (disorder) {770890009 , SNOMED-CT } Other Relationships No other relationships ...
more infohttps://phinvads.cdc.gov/vads/ViewCodeSystemConcept.action?oid=2.16.840.1.113883.6.96&code=770709005

Factor XII deficiency - Canadian Hemophilia SocietyFactor XII deficiency - Canadian Hemophilia Society

Congenital factor XII deficiency is an inherited coagulation protein deficiency disorder. This means that it is passed on from ... The coagulation protein deficiency is caused by an abnormal gene.. Each cell of the body contains structures called " ... Factor XII is a protein in the blood. It plays a role in the coagulation cascade. Blood is carried throughout the body in a ... It will inform the medical professionals of your coagulation disorder and your ability to form a clot within a normal time. ...
more infohttp://www.hemophilia.ca/en/bleeding-disorders/other-factor-deficiencies/factor-xii-deficiency/

Meningococcemia/purpura fulminans - Renal and Urology NewsMeningococcemia/purpura fulminans - Renal and Urology News

Inherited coagulation disorders such as protein S or C deficiency.. Thrombotic thrombocytopenic purpura (TTP). ... Activated protein C (drotrecogin alfa, Xigris®) may be considered for adult patients only:. Administration of activated protein ... Efficacy and safety of recombinant human activated protein C for severe sepsis". N Engl J Med. vol. 344. 2001 Mar 8. pp. 699- ... Activated protein C administration is contraindicated in pediatric patients due to lack of efficacy in published trials and ...
more infohttps://www.renalandurologynews.com/home/decision-support-in-medicine/critical-care-medicine/meningococcemia-purpura-fulminans/

Care Austria • online application • Care Austria Health insurance, students insurance, insurance for language pupils, insurance...Care Austria • online application • Care Austria Health insurance, students insurance, insurance for language pupils, insurance...

Because of coagulation disorders (e.g. "protein S deficiency", "factor 5 deficiency")? Yes. No. ... Is there or has there been a drug, alcohol or drug addiction (other than nicotine consumption) or an eating disorder? Yes. No. ... Is there or has there been a drug, alcohol or drug addiction (other than nicotine consumption) or an eating disorder?. Yes. No ... Is there or has there been a drug, alcohol or drug addiction (other than nicotine consumption) or an eating disorder?. Yes. No ...
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Care Concept AG • Overseas health cover for students, language pupils, aupairs, foreign guests and visitors in Austria • Care...Care Concept AG • Overseas health cover for students, language pupils, aupairs, foreign guests and visitors in Austria • Care...

Because of coagulation disorders (e.g. "protein S deficiency", "factor 5 deficiency")? Yes. No. ... Is there or has there been a drug, alcohol or drug addiction (other than nicotine consumption) or an eating disorder? Yes. No. ... Is there or has there been a drug, alcohol or drug addiction (other than nicotine consumption) or an eating disorder?. Yes. No ... Is there or has there been a drug, alcohol or drug addiction (other than nicotine consumption) or an eating disorder?. Yes. No ...
more infohttp://www.care-concept.de/krankenversicherung/care_austria/krankenversicherung_oesterreich_e-antrag_eng.php?vmnr=0021870000&navilang=eng

Haematology :: Williams Manual of Hematology international edition - Ζήτα - Ιατρικές ΕκδόσειςHaematology :: Williams Manual of Hematology international edition - Ζήτα - Ιατρικές Εκδόσεις

... reference been carefully edited deliver only most clinical point-of-care facts Covering both common uncommon blood disorders ... Manual Hematology concise easy-to-navigate compilation pathogenic diagnostic therapeutic essentials blood cell coagulation ... protein disorders Referenced classic Williams Hematology this handy easily transported ... and therapeutic essentials of blood cell and coagulation protein disorders. Referenced to the classic Williams Hematology, 8e, ...
more infohttps://zerbinis.gr/williams-manual-of-hematology.html
  • This seemingly paradoxical propensity to develop thrombosis in a disorder causing a decrease in a critical protein for blood clotting may be due to the function of fibrin (the split product of fibrinogen that is the basis for forming blood clots) to promote the lysis or desolution of blood clots. (wikipedia.org)
  • LACHEN, Switzerland and HOBOKEN, N.J., July 23 Octapharma USA is now accepting applications for the Octapharma 25th Anniversary Grants Program, which supports clinical or pre-clinical research focused on human protein therapies in coagulation disorders, immunotherapy, intensive care and emergency medicine. (medindia.net)
  • As soon as a blood vessel wall breaks, the components responsible for coagulation come together to form a plug at the break. (hemophilia.ca)
  • The common form of C1 tends to be found in the high-density protein complexes (HDL) that ferry cholesterol to storage depots in the body and are linked to lower cardiovascular disease risk. (rxpgnews.com)
  • But the variant form of C1 tends to become part of low density protein complexes (LDL), which transport cholesterol to arterial walls and are associated with higher cardiovascular disease risk. (rxpgnews.com)
  • We have been committed to patient care and medical innovation since day one and our vision of providing patients with the safest, highest quality human protein therapies available is stronger than ever," said Octapharma USA President Flemming Nielsen. (medindia.net)
  • A clotting (or coagulation) disorder is a medical condition where a specific protein is missing from the blood. (gosh.nhs.uk)
  • In older children and adults the suspicion of a clotting disorder might arise during routine checks before an operation or following an injury. (gosh.nhs.uk)
  • Some people do not have the genes necessary for producing coagulation elements. (wisegeek.com)
  • RxPG] University of Minnesota researchers have discovered a variant of a common blood protein, apolipoprotein C1, in people of American Indian and Mexican ancestry that is linked to elevated body mass index (BMI), obesity and Type 2 diabetes. (rxpgnews.com)
  • The funds were used to apply new proteomics technology to screen blood samples for proteins related to disease. (rxpgnews.com)
  • Octapharma's core business is the development, production and sale of high quality human protein therapies, including immune globulin intravenous (IGIV). (medindia.net)
  • In the U.S., Octapharma's IGIV product, octagam(R) (immune globulin intravenous [human] 5%), is used to treat disorders of the immune system, and Octapharma's Albumin (Human) is indicated for the restoration and maintenance of circulating blood volume. (medindia.net)
  • The average body mass index (BMI) of persons with the variant protein was 9 percent higher and the diabetes rate 50 percent higher among study subjects and their parents. (rxpgnews.com)
  • Treatment of bleeding diathesis can vary, since there are different types of the disorder, although all methods are alike in that they aim to reduce the amount of bleeding. (wisegeek.com)
  • Is there or has there been a drug, alcohol or drug addiction (other than nicotine consumption) or an eating disorder? (care-concept.de)