Agents that cause clotting.
Heat- and storage-stable plasma protein that is activated by tissue thromboplastin to form factor VIIa in the extrinsic pathway of blood coagulation. The activated form then catalyzes the activation of factor X to factor Xa.
The process of the interaction of BLOOD COAGULATION FACTORS that results in an insoluble FIBRIN clot.
Blood-coagulation factor VIII. Antihemophilic factor that is part of the factor VIII/von Willebrand factor complex. Factor VIII is produced in the liver and acts in the intrinsic pathway of blood coagulation. It serves as a cofactor in factor X activation and this action is markedly enhanced by small amounts of thrombin.
The most common mineral of a group of hydrated aluminum silicates, approximately H2Al2Si2O8-H2O. It is prepared for pharmaceutical and medicinal purposes by levigating with water to remove sand, etc. (From Merck Index, 11th ed) The name is derived from Kao-ling (Chinese: "high ridge"), the original site. (From Grant & Hackh's Chemical Dictionary, 5th ed)
Laboratory tests for evaluating the individual's clotting mechanism.
Storage-stable glycoprotein blood coagulation factor that can be activated to factor Xa by both the intrinsic and extrinsic pathways. A deficiency of factor X, sometimes called Stuart-Prower factor deficiency, may lead to a systemic coagulation disorder.
Storage-stable blood coagulation factor acting in the intrinsic pathway. Its activated form, IXa, forms a complex with factor VIII and calcium on platelet factor 3 to activate factor X to Xa. Deficiency of factor IX results in HEMOPHILIA B (Christmas Disease).
A plant species of the family Moringaceae, order Capparales, subclass Dilleniidae. It is a source of niaziminin and hypotensive thiocarbamate glycosides.
A hereditary deficiency of blood coagulation factor XI (also known as plasma thromboplastin antecedent or PTA or antihemophilic factor C) resulting in a systemic blood-clotting defect called hemophilia C or Rosenthal's syndrome, that may resemble classical hemophilia.
Constituent composed of protein and phospholipid that is widely distributed in many tissues. It serves as a cofactor with factor VIIa to activate factor X in the extrinsic pathway of blood coagulation.
An autosomal recessive characteristic or a coagulation disorder acquired in association with VITAMIN K DEFICIENCY. FACTOR VII is a Vitamin K dependent glycoprotein essential to the extrinsic pathway of coagulation.
Endogenous peptides present in most body fluids. Certain enzymes convert them to active KININS which are involved in inflammation, blood clotting, complement reactions, etc. Kininogens belong to the cystatin superfamily. They are cysteine proteinase inhibitors. HIGH-MOLECULAR-WEIGHT KININOGEN; (HMWK); is split by plasma kallikrein to produce BRADYKININ. LOW-MOLECULAR-WEIGHT KININOGEN; (LMWK); is split by tissue kallikrein to produce KALLIDIN.
Endogenous substances, usually proteins, that are involved in the blood coagulation process.
Activated form of factor XI. In the intrinsic pathway, Factor XI is activated to XIa by factor XIIa in the presence of cofactor HMWK; (HIGH MOLECULAR WEIGHT KININOGEN). Factor XIa then activates factor IX to factor IXa in the presence of calcium.
Arginine derivative which is a substrate for many proteolytic enzymes. As a substrate for the esterase from the first component of complement, it inhibits the action of C(l) on C(4).
Stable blood coagulation factor involved in the intrinsic pathway. The activated form XIa activates factor IX to IXa. Deficiency of factor XI is often called hemophilia C.
Clotting time of PLASMA recalcified in the presence of excess TISSUE THROMBOPLASTIN. Factors measured are FIBRINOGEN; PROTHROMBIN; FACTOR V; FACTOR VII; and FACTOR X. It is used for monitoring anticoagulant therapy with COUMARINS.
The classic hemophilia resulting from a deficiency of factor VIII. It is an inherited disorder of blood coagulation characterized by a permanent tendency to hemorrhage.
A plasma protein which is the precursor of kallikrein. Plasma that is deficient in prekallikrein has been found to be abnormal in thromboplastin formation, kinin generation, evolution of a permeability globulin, and plasmin formation. The absence of prekallikrein in plasma leads to Fletcher factor deficiency, a congenital disease.
Procedures using an electrically heated wire or scalpel to treat hemorrhage (e.g., bleeding ulcers) and to ablate tumors, mucosal lesions, and refractory arrhythmias. It is different from ELECTROSURGERY which is used more for cutting tissue than destroying and in which the patient is part of the electric circuit.
A genus of poisonous snakes of the VIPERIDAE family. About 50 species are known and all are found in tropical America and southern South America. Bothrops atrox is the fer-de-lance and B. jararaca is the jararaca. (Goin, Goin, and Zug, Introduction to Herpetology, 3d ed, p336)
The time required for the appearance of FIBRIN strands following the mixing of PLASMA with phospholipid platelet substitute (e.g., crude cephalins, soybean phosphatides). It is a test of the intrinsic pathway (factors VIII, IX, XI, and XII) and the common pathway (fibrinogen, prothrombin, factors V and X) of BLOOD COAGULATION. It is used as a screening test and to monitor HEPARIN therapy.
Activated form of factor VII. Factor VIIa activates factor X in the extrinsic pathway of blood coagulation.
Dysprosium. An element of the rare earth family that has the atomic symbol Dy, atomic number 66, and atomic weight 162.50. Dysprosium is a silvery metal used primarily in the form of various salts.
An enzyme formed from PROTHROMBIN that converts FIBRINOGEN to FIBRIN.
Activated form of factor XII. In the initial event in the intrinsic pathway of blood coagulation, kallikrein (with cofactor HIGH MOLECULAR WEIGHT KININOGEN) cleaves factor XII to XIIa. Factor XIIa is then further cleaved by kallikrein, plasmin, and trypsin to yield smaller factor XII fragments (Hageman-Factor fragments). These fragments increase the activity of prekallikrein to kallikrein but decrease the procoagulant activity of factor XII.
Venoms from snakes of the subfamily Crotalinae or pit vipers, found mostly in the Americas. They include the rattlesnake, cottonmouth, fer-de-lance, bushmaster, and American copperhead. Their venoms contain nontoxic proteins, cardio-, hemo-, cyto-, and neurotoxins, and many enzymes, especially phospholipases A. Many of the toxins have been characterized.
Neodymium. An element of the rare earth family of metals. It has the atomic symbol Nd, atomic number 60, and atomic weight 144.24, and is used in industrial applications.
Group of hemorrhagic disorders in which the VON WILLEBRAND FACTOR is either quantitatively or qualitatively abnormal. They are usually inherited as an autosomal dominant trait though rare kindreds are autosomal recessive. Symptoms vary depending on severity and disease type but may include prolonged bleeding time, deficiency of factor VIII, and impaired platelet adhesion.
Plasma glycoprotein clotted by thrombin, composed of a dimer of three non-identical pairs of polypeptide chains (alpha, beta, gamma) held together by disulfide bonds. Fibrinogen clotting is a sol-gel change involving complex molecular arrangements: whereas fibrinogen is cleaved by thrombin to form polypeptides A and B, the proteolytic action of other enzymes yields different fibrinogen degradation products.
A plasma protein that is the inactive precursor of thrombin. It is converted to thrombin by a prothrombin activator complex consisting of factor Xa, factor V, phospholipid, and calcium ions. Deficiency of prothrombin leads to hypoprothrombinemia.
A chromogenic substrate that permits direct measurement of peptide hydrolase activity, e.g., papain and trypsin, by colorimetry. The substrate liberates p-nitroaniline as a chromogenic product.
Limbless REPTILES of the suborder Serpentes.
Stable blood coagulation factor activated by contact with the subendothelial surface of an injured vessel. Along with prekallikrein, it serves as the contact factor that initiates the intrinsic pathway of blood coagulation. Kallikrein activates factor XII to XIIa. Deficiency of factor XII, also called the Hageman trait, leads to increased incidence of thromboembolic disease. Mutations in the gene for factor XII that appear to increase factor XII amidolytic activity are associated with HEREDITARY ANGIOEDEMA TYPE III.
Hemorrhagic and thrombotic disorders that occur as a consequence of abnormalities in blood coagulation due to a variety of factors such as COAGULATION PROTEIN DISORDERS; BLOOD PLATELET DISORDERS; BLOOD PROTEIN DISORDERS or nutritional conditions.
Substances that are recognized by the immune system and induce an immune reaction.
A method of tissue ablation and bleeding control that uses ARGON plasma (ionized argon gas) to deliver a current of thermocoagulating energy to the area of tissue to be coagulated.
A high-molecular-weight plasma protein, produced by endothelial cells and megakaryocytes, that is part of the factor VIII/von Willebrand factor complex. The von Willebrand factor has receptors for collagen, platelets, and ristocetin activity as well as the immunologically distinct antigenic determinants. It functions in adhesion of platelets to collagen and hemostatic plug formation. The prolonged bleeding time in VON WILLEBRAND DISEASES is due to the deficiency of this factor.
Activated form of factor IX. This activation can take place via the intrinsic pathway by the action of factor XIa and calcium, or via the extrinsic pathway by the action of factor VIIa, thromboplastin, and calcium. Factor IXa serves to activate factor X to Xa by cleaving the arginyl-leucine peptide bond in factor X.
Antisera used to counteract poisoning by animal VENOMS, especially SNAKE VENOMS.
Heat- and storage-labile plasma glycoprotein which accelerates the conversion of prothrombin to thrombin in blood coagulation. Factor V accomplishes this by forming a complex with factor Xa, phospholipid, and calcium (prothrombinase complex). Deficiency of factor V leads to Owren's disease.
Solutions or mixtures of toxic and nontoxic substances elaborated by snake (Ophidia) salivary glands for the purpose of killing prey or disabling predators and delivered by grooved or hollow fangs. They usually contain enzymes, toxins, and other factors.
A plant genus of the family LAMIACEAE that contains leonurine.
Activated form of factor X that participates in both the intrinsic and extrinsic pathways of blood coagulation. It catalyzes the conversion of prothrombin to thrombin in conjunction with other cofactors.
The process which spontaneously arrests the flow of BLOOD from vessels carrying blood under pressure. It is accomplished by contraction of the vessels, adhesion and aggregation of formed blood elements (eg. ERYTHROCYTE AGGREGATION), and the process of BLOOD COAGULATION.
All blood proteins except albumin ( = SERUM ALBUMIN, which is not a globulin) and FIBRINOGEN (which is not in the serum). The serum globulins are subdivided into ALPHA-GLOBULINS; BETA-GLOBULINS; and GAMMA-GLOBULINS on the basis of their electrophoretic mobilities. (From Dorland, 28th ed)
Activated form of factor VIII. The B-domain of factor VIII is proteolytically cleaved by thrombin to form factor VIIIa. Factor VIIIa exists as a non-covalent dimer in a metal-linked (probably calcium) complex and functions as a cofactor in the enzymatic activation of factor X by factor IXa. Factor VIIIa is similar in structure and generation to factor Va.
The natural enzymatic dissolution of FIBRIN.
Clotting time of PLASMA mixed with a THROMBIN solution. It is a measure of the conversion of FIBRINOGEN to FIBRIN, which is prolonged by AFIBRINOGENEMIA, abnormal fibrinogen, or the presence of inhibitory substances, e.g., fibrin-fibrinogen degradation products, or HEPARIN. BATROXOBIN, a thrombin-like enzyme unaffected by the presence of heparin, may be used in place of thrombin.
A plasma alpha 2 glycoprotein that accounts for the major antithrombin activity of normal plasma and also inhibits several other enzymes. It is a member of the serpin superfamily.
Proteolytic enzymes from the serine endopeptidase family found in normal blood and urine. Specifically, Kallikreins are potent vasodilators and hypotensives and increase vascular permeability and affect smooth muscle. They act as infertility agents in men. Three forms are recognized, PLASMA KALLIKREIN (EC, TISSUE KALLIKREIN (EC, and PROSTATE-SPECIFIC ANTIGEN (EC
A synthetic analog of the pituitary hormone, ARGININE VASOPRESSIN. Its action is mediated by the VASOPRESSIN receptor V2. It has prolonged antidiuretic activity, but little pressor effects. It also modulates levels of circulating FACTOR VIII and VON WILLEBRAND FACTOR.
That portion of the electromagnetic spectrum from the UHF (ultrahigh frequency) radio waves and extending into the INFRARED RAYS frequencies.
A disorder characterized by procoagulant substances entering the general circulation causing a systemic thrombotic process. The activation of the clotting mechanism may arise from any of a number of disorders. A majority of the patients manifest skin lesions, sometimes leading to PURPURA FULMINANS.
Poisonous animal secretions forming fluid mixtures of many different enzymes, toxins, and other substances. These substances are produced in specialized glands and secreted through specialized delivery systems (nematocysts, spines, fangs, etc.) for disabling prey or predator.
A vitamin-K dependent zymogen present in the blood, which, upon activation by thrombin and thrombomodulin exerts anticoagulant properties by inactivating factors Va and VIIIa at the rate-limiting steps of thrombin formation.
Venoms from SNAKES of the viperid family. They tend to be less toxic than elapid or hydrophid venoms and act mainly on the vascular system, interfering with coagulation and capillary membrane integrity and are highly cytotoxic. They contain large amounts of several enzymes, other factors, and some toxins.
A di-isopropyl-fluorophosphate which is an irreversible cholinesterase inhibitor used to investigate the NERVOUS SYSTEM.
Non-nucleated disk-shaped cells formed in the megakaryocyte and found in the blood of all mammals. They are mainly involved in blood coagulation.
A deficiency of blood coagulation factor IX inherited as an X-linked disorder. (Also known as Christmas Disease, after the first patient studied in detail, not the holy day.) Historical and clinical features resemble those in classic hemophilia (HEMOPHILIA A), but patients present with fewer symptoms. Severity of bleeding is usually similar in members of a single family. Many patients are asymptomatic until the hemostatic system is stressed by surgery or trauma. Treatment is similar to that for hemophilia A. (From Cecil Textbook of Medicine, 19th ed, p1008)
The sum of the weight of all the atoms in a molecule.
The residual portion of BLOOD that is left after removal of BLOOD CELLS by CENTRIFUGATION without prior BLOOD COAGULATION.
A thrombin receptor subtype that couples to HETEROTRIMERIC GTP-BINDING PROTEINS resulting in the activation of a variety of signaling mechanisms including decreased intracellular CYCLIC AMP, increased TYPE C PHOSPHOLIPASES and increased PHOSPHOLIPASE A2.
Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.
A family of proteinase-activated receptors that are specific for THROMBIN. They are found primarily on PLATELETS and on ENDOTHELIAL CELLS. Activation of thrombin receptors occurs through the proteolytic action of THROMBIN, which cleaves the N-terminal peptide from the receptor to reveal a new N-terminal peptide that is a cryptic ligand for the receptor. The receptors signal through HETEROTRIMERIC GTP-BINDING PROTEINS. Small synthetic peptides that contain the unmasked N-terminal peptide sequence can also activate the receptor in the absence of proteolytic activity.
Agents that prevent clotting.
Formation and development of a thrombus or blood clot in the blood vessel.
Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.
A protein derived from FIBRINOGEN in the presence of THROMBIN, which forms part of the blood clot.
Separation technique in which the stationary phase consists of ion exchange resins. The resins contain loosely held small ions that easily exchange places with other small ions of like charge present in solutions washed over the resins.
Chromatography on non-ionic gels without regard to the mechanism of solute discrimination.
A layer of epithelium that lines the heart, blood vessels (ENDOTHELIUM, VASCULAR), lymph vessels (ENDOTHELIUM, LYMPHATIC), and the serous cavities of the body.
The rate dynamics in chemical or physical systems.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
The attachment of PLATELETS to one another. This clumping together can be induced by a number of agents (e.g., THROMBIN; COLLAGEN) and is part of the mechanism leading to the formation of a THROMBUS.
Univalent antigen-binding fragments composed of one entire IMMUNOGLOBULIN LIGHT CHAIN and the amino terminal end of one of the IMMUNOGLOBULIN HEAVY CHAINS from the hinge region, linked to each other by disulfide bonds. Fab contains the IMMUNOGLOBULIN VARIABLE REGIONS, which are part of the antigen-binding site, and the first IMMUNOGLOBULIN CONSTANT REGIONS. This fragment can be obtained by digestion of immunoglobulins with the proteolytic enzyme PAPAIN.
The time frame after a meal or FOOD INTAKE.
A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges. The molecular weight ranges from six to twenty thousand. Heparin occurs in and is obtained from liver, lung, mast cells, etc., of vertebrates. Its function is unknown, but it is used to prevent blood clotting in vivo and vitro, in the form of many different salts.
Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.
An essential amino acid that is physiologically active in the L-form.
Lipids containing one or more phosphate groups, particularly those derived from either glycerol (phosphoglycerides see GLYCEROPHOSPHOLIPIDS) or sphingosine (SPHINGOLIPIDS). They are polar lipids that are of great importance for the structure and function of cell membranes and are the most abundant of membrane lipids, although not stored in large amounts in the system.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
A member of the serpin family of proteins. It inhibits both the tissue-type and urokinase-type plasminogen activators.
Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.
Fats present in food, especially in animal products such as meat, meat products, butter, ghee. They are present in lower amounts in nuts, seeds, and avocados.
The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.
Elements of limited time intervals, contributing to particular results or situations.
Conversion of an inactive form of an enzyme to one possessing metabolic activity. It includes 1, activation by ions (activators); 2, activation by cofactors (coenzymes); and 3, conversion of an enzyme precursor (proenzyme or zymogen) to an active enzyme.
Proteins prepared by recombinant DNA technology.
A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
Antibodies produced by a single clone of cells.
The parts of a macromolecule that directly participate in its specific combination with another molecule.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.

Leukocyte microparticles stimulate endothelial cell cytokine release and tissue factor induction in a JNK1 signaling pathway. (1/178)

A role of membrane microparticles (MP) released by vascular cells in endothelial cell (EC) activation was investigated. Flow cytofluorimetric analysis of blood samples from normal volunteers revealed the presence of an heterogeneous MP population, which increased by approximately 2-fold after inflammatory stimulation with the chemotactic peptide, N-formyl-Met-Leu-Phe (2,799 +/- 360 versus 5241 +/- 640, p < 0.001). Blood-derived MP stimulated release of EC cytokines interleukin (IL)-6 (377 +/- 68 pg/ml) and MCP-1 (1, 282 +/- 79) and up-regulated de novo expression of tissue factor on the EC surface. This was associated with generation of a factor Xa-dependent procoagulant response (2.28 +/- 0.56 nM factor Xa/min/10(4) cells), in a reaction inhibited by a monoclonal antibody to tissue factor. Fluorescent labeling with antibodies to platelet GPIbalpha or leukocyte lactoferrin demonstrated that circulating MP originated from both platelets and leukocytes. However, depletion of platelet MP with an antibody to GPIbalpha did not reduce EC IL-6 release, and, similarly, MP from thrombin-stimulated platelets did not induce IL-6 release from endothelium. EC stimulation with leukocyte MP did not result in activation of the transcription factor NF-kappaB and was not associated with tyrosine phosphorylation of extracellular signal-regulated protein kinase, ERK1. In contrast, leukocyte MP stimulated a sustained, time-dependent increased tyrosine phosphorylation of approximately 46-kDa c-Jun NH(2)-terminal kinase (JNK1) in EC. These findings demonstrate that circulating leukocyte MP are up-regulated by inflammatory stimulation in vivo and activate a stress signaling pathway in EC, leading to increased procoagulant and proinflammatory activity. This may provide an alternative mechanism of EC activation, potentially contributing to dysregulation of endothelial functions during vascular injury.  (+info)

Procoagulant effect of anti-beta2-glycoprotein I antibodies with lupus anticoagulant activity. (2/178)

Prothrombin time (PT) is routinely used to monitor oral anticoagulant treatment in patients with the antiphospholipid antibody syndrome (APS). The fact that PT is a phospholipid (PL)-dependent coagulation test raises the possibility that lupus anticoagulant (LA) might interfere with this test, thus complicating the control of anticoagulant treatment. The effect of 6 affinity-purified preparations of anti- (a)beta2-glycoprotein I (GPI) antibodies with LA activity on the PT was tested. Instead of prolonging PT as expected, the abeta2-GPI antibodies reduced the PT of both normal plasma and anticoagulated plasma by a mean of 2.4 seconds and 5.6 seconds, respectively. This effect was also observed using other 5 commercially available preparations of thromboplastin. The abeta2-GPI-mediated reduction in PT was dose-dependent and was lost upon removal of beta2-GPI. The failure of abeta2-GPI antibodies to express LA activity in PT was found to depend on the fact that calcium ions were added together with PL at the beginning of the assay. In fact, modification of the standard diluted Russell viper venom time (dRVVT) test by adding calcium ions together with PL resulted in a loss of abeta2-GPI anticoagulant activity. The procoagulant effect was not as evident in an assay that used stimulated monocytes as a source of thromboplastin. These results show that abeta2-GPI antibodies exhibit an 'in vitro' procoagulant effect in PT and an anticoagulant effect in dRVVT only when the interaction with their antigen and PL occurs in the absence of calcium ions.  (+info)

Platelet factor 4-induced neutrophil-endothelial cell interaction: involvement of mechanisms and functional consequences different from those elicited by interleukin-8. (3/178)

Platelet factor 4 (PF-4), a member of the CXC-subfamily of chemokines, is secreted in high amounts by activated platelets. In previous studies, we found that PF-4 specifically binds to human polymorphonuclear granulocytes (PMN), but requires tumor necrosis factor-alpha (TNF-alpha) as a costimulus for the induction of effector functions in suspended cells. In the present study, we have examined PF-4 in comparison with interleukin-8 (IL-8) for its ability to promote interaction of PMN with cultured endothelial cells (EC). We show here for the first time that PF-4 dose-dependently induces PMN to undergo extremely firm adhesion to EC as well as to exocytose secondary granule contents in the presence of these cells. Interestingly, costimulation by TNF-alpha was not required, indicating that EC could provide a corresponding signal(s). As evident from antibody blocking experiments, PF-4-induced adhesion involved PMN-expressed L-selectin as well as leukocyte function-associated molecule-1 (LFA-1), whereas IL-8 involved MAC-1. Because blocking antibodies to LFA-1 but not to L-selectin or MAC-1 abrogated PF-4-dependent marker exocytosis from PMN, the costimulatory signal provided by EC appears to be elicited through cell-cell contact via LFA-1. IL-8, inducing the upregulation of MAC-1, did not elicit marker exocytosis in contact with EC. Our results suggest a role for PF-4 in the promotion of PMN-EC interaction that is virtually different from that exhibited by other CXC-chemokines such as IL-8.  (+info)

Hydrophobic contact between the two epidermal growth factor-like domains of blood coagulation factor IX contributes to enzymatic activity. (4/178)

The three-dimensional structure of activated factor IX comprises multiple contacts between the two epidermal growth factor (EGF)-like domains. One of these is a salt bridge between Glu(78) and Arg(94), which is essential for binding of factor IXa to its cofactor factor VIII and for factor VIII-dependent factor X activation (Christophe, O. D., Lenting, P. J., Kolkman, J. A., Brownlee, G. G., and Mertens, K. (1998) J. Biol. Chem. 273, 222-227). We now addressed the putative hydrophobic contact at the interface between the EGF-like domains. Recombinant factor IX chimeras were constructed in which hydrophobic regions Phe(75)-Phe(77) and Lys(106)-Val(108) were replaced by the corresponding sites of factor X and factor VII. Activated factor IX/factor X chimeras were indistinguishable from normal factor IXa with respect to factor IXa enzymatic activity. In contrast, factor IXa(75-77)/factor VII displayed approximately 2-fold increased factor X activation in the presence of factor VIII, suggesting that residues 75-77 contribute to cofactor-dependent factor X activation. Activation of factor X by factor IX(106-108)/factor VII was strongly decreased, both in the absence and presence of factor VIII. Activity could be restored by simultaneous substitution of the hydrophobic sites in both EGF-like domains for factor VII residues. These data suggest that factor IXa enzymatic activity requires hydrophobic contact between the two EGF-like domains.  (+info)

Phosphatidylinositol 3,4,5-trisphosphate regulates Ca(2+) entry via btk in platelets and megakaryocytes without increasing phospholipase C activity. (5/178)

The role of phosphatidylinositol 3,4,5-trisphosphate (PI3,4,5P(3)) and Btk in signalling by the collagen receptor glycoprotein VI was investigated. PI3,4,5P(3) was increased in platelets from mice deficient in the SH2 domain-containing inositol 5-phosphatase (SHIP), in response to collagen related peptide (CRP). Tyrosine phosphorylation and activation of phospholipase Cgamma2 (PLCgamma2) were unaltered in SHIP(-/-) platelets, whereas Btk was heavily tyrosine phosphorylated under basal conditions and maximally phosphorylated by low concentrations of CRP. There was an increase in basal Ca(2+), maximal expression of P-selectin, and potentiation of Ca(2+) and aminophospholipid exposure to CRP in SHIP(-/-) platelets in the presence of Ca(2+) (1 mM). Microinjection of PI3,4, 5P(3) into megakaryocytes caused a 3-fold increase in Ca(2+) in response to CRP, which was absent in X-linked immunodeficiency (Xid) mice, which have a mutation in the PH domain of Btk. There was a corresponding partial reduction in the sustained level of intracellular Ca(2+) in response to CRP in Xid mice but no change in PLC activity. These results demonstrate a novel pathway of Ca(2+) entry that involves PI3,4,5P(3) and Btk, and which is independent of increased PLC activity.  (+info)

A plasma kallikrein-dependent plasminogen cascade required for adipocyte differentiation. (6/178)

Here we show that plasma kallikrein (PKal) mediates a plasminogen (Plg) cascade in adipocyte differentiation. Ecotin, an inhibitor of serine proteases, inhibits cell-shape change, adipocyte-specific gene expression, and lipid accumulation during adipogenesis in culture. Deficiency of Plg, but not of urokinase or tissue-type plasminogen activator, suppresses adipogenesis during differentiation of 3T3-L1 cells and mammary-gland involution. PKal, which is inhibited by ecotin, is required for adipose conversion, Plg activation and 3T3-L1 differentiation. Human plasma lacking PKal does not support differentiation of 3T3-L1 cells. PKal is therefore a physiological regulator that acts in the Plg cascade during adipogenesis. We propose that the Plg cascade fosters adipocyte differentiation by degradation of the fibronectin-rich preadipocyte stromal matrix.  (+info)

Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen. (7/178)

Platelet adhesion on and activation by components of the extracellular matrix are crucial to arrest post-traumatic bleeding, but can also harm tissue by occluding diseased vessels. Integrin alpha2beta1 is thought to be essential for platelet adhesion to subendothelial collagens, facilitating subsequent interactions with the activating platelet collagen receptor, glycoprotein VI (GPVI). Here we show that Cre/loxP-mediated loss of beta1 integrin on platelets has no significant effect on the bleeding time in mice. Aggregation of beta1-null platelets to native fibrillar collagen is delayed, but not reduced, whereas aggregation to enzymatically digested soluble collagen is abolished. Furthermore, beta1-null platelets adhere to fibrillar, but not soluble collagen under static as well as low (150 s(-1)) and high (1000 s(-1)) shear flow conditions, probably through binding of alphaIIbbeta3 to von Willebrand factor. On the other hand, we show that platelets lacking GPVI can not activate integrins and consequently fail to adhere to and aggregate on fibrillar as well as soluble collagen. These data show that GPVI plays the central role in platelet-collagen interactions by activating different adhesive receptors, including alpha2beta1 integrin, which strengthens adhesion without being essential.  (+info)

Femoral artery thrombosis after percutaneous thrombin injection of an external iliac artery pseudoaneurysm. (8/178)

Ultrasound-guided percutaneous thrombin injection has been developed as a less invasive and highly successful treatment of iatrogenic femoral pseudoaneurysms. Most of these lesions have been the result of catheterization procedures. This method has proved to be highly effective, and few complications have been reported. Specifically, native arterial thrombosis, although recognized as a severe complication, has been mentioned only briefly in the literature. We present a case of the successful management of native arterial thrombosis after attempted percutaneous thrombin injection of a chronic external iliac artery pseudoaneurysm. This case serves to illustrate the risk factors for this complication and the treatment options once it occurs. The success of this treatment with acute iatrogenic femoral pseudoaneurysms may not necessarily translate into similar success in other anatomic locations and clinical situations.  (+info)

The aim of the present study was to investigate the long-term effects of chitosan-glycerol phosphate (chitosan- GP) gel with the articular environment following implantat..
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TEGO® Coagulant 4720. Based on polyfunctional non-ionic ingredients. Coagulant that works by heat sensitation of natural and synthetic latex. ...
The TouchSoft Coagulator® monopolar probe is a unique endoscopic accessory used for contact coagulation or tissue ablation throughout the colon.
View Test Prep - IMG-1981.jpg from NURSING 143 at ECPI University, Charlotte. MEDICATION Heparin REVIEW MODULE CHAPTER. CATEGORY CLASS Anti coagulant PURPOSE OF MEDICATION Expected Pharmacological
|h3||strong|CHINFIELD COAGULANT|/strong||/h3| |p||strong|Antihemorrhagic|/strong||/p| |p||strong|Benefits:|/strong| COAGULANTE CHINFIELD covers the whole picture of hemorrhages whatever their etiology and location thanks to the two active components of
ULTRION Coagulants were developed to handle the wide seasonal variation of surface waters to produce a consistent, high quality, and economical water source into your processes. | Ecolab
On rFVIIIFc Day 0, all participants underwent pharmacokinetic (PK) analysis with 50 IU/kg rFVIIIFc to estimate their PK parameters and guide the appropriate dose or interval of dosing. A subset of participants (Sequential PK subgroup) also had PK analyses performed with a single dose of 50 IU/kg Advate (Advate Day 0) within 8 weeks prior to rFVIIIFc Day 0. A ,= 96 hour washout was performed before the PK dose of Advate or rFVIIIFc was administered. Repeat PK profiling with a single dose of 50 IU/kg rFVIIIFc was conducted at Week 14 or after 12 to 24 weeks of prophylaxis with rFVIIIFc.. After PK assessments, all participants started twice weekly treatment with 25 IU/kg of rFVIIIFc via intravenous (IV) injection on Day 1 and 50 IU/kg on Day 4, followed by individualized dose and interval modification within the range of 25 to 65 IU/kg every 3 to 5 days, as determined by rFVIIIFc PK analysis, to maintain a trough level of 1% to 3% (or higher, as clinically indicated) FVIII activity.. ...
PK subgroup: After a Washout Period of ≥72 hours, at the Baseline Visit (28±7 days prior to Day 1), participants receive a single IV injection of prestudy FVIII over 5 (±2) minutes at a dose of 50 IU/kg, rounded up to the nearest 250 IU increment, for a PK assessment. Following a second Washout Period of ≥72 hours, participants receive a single IV injection of rFVIIIFc over 5 (±2) minutes at a dose of 50 IU/kg for PK assessment. The first prophylactic dose of rFVIIIFc is administered at a starting dose of 25 IU/kg IV injection on Day 1 and 50 IU/kg on Day 4. Dose increases to a maximum of 80 IU/kg, and frequency of administration to a minimum interval of once every 2 days, are allowed as indicated.. Non-PK subgroup: On Day 1, a first prophylactic dose of rFVIIIFc of 25 IU/kg IV injection is given, followed by a dose of 50 IU/kg on Day 4. Dose increases to a maximum of 80 IU/kg, and frequency of administration to a minimum interval of once every 2 days, are allowed as indicated. ...
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Article Effectiveness of coagulants and coagulant aids for the removal of filter-clogging Synedra. The occurrence of Synedra spp. in the source water of the CheongJu water treatment plant (South Korea) decreased filter run times of rapid sand filters...
TM 55-1930-209-14&P-1 Legend for Control Symbols Located on Inhibitor Pump and Coagulant Covers Figure 13-10. Coagulant and Inhibitor Pump Controls (Sheet 2 of 2) 13-19 ...
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A comprehensive guide to side effects including common and rare side effects when taking Feiba VH (Anti-Inhibitor Coagulant Complex, Vapor Heated ) includes uses, warnings, and drug interactions.
ULTRION Coagulants were developed to handle the wide seasonal variation of surface waters to produce a consistent, high quality, and economical water source into your processes. | Nalco Water
Find polyelectrolyte coagulant articles on Environmental XPRT, the worlds largest environmental industry marketplace and information resource.
Can lead to behavioral working final Cut Pro year after April 30. Span classsp_pss430 itemsspannbsp018332Find homes Lebanese satellite television station coagulants in treatment wastewater listings in Collierville.
I have just been diagnosed with AF at age 51. I am taking beta bockers but have been told that it will be 2 weeks before I can get to the Warfarin Clinic. What...
In addition to being a key component of the retention and drainage program, other applications include dye fixation, pitch and stickies control, coated broke treatment and alkaline size promotion. | Nalco Water
Home cheesemaking can involve more than milk, starter culture, and coagulant. Additives can change the flavor, consistency, and texture of homemade cheese.
The development of Prothrombin Complex Concentrates (PCCs) has led to better outcomes in patients receiving emergency reversal of warfarin. However, most published data describes the use of PCCs in the setting of major bleeding or emergent major surgery, with little information on neuraxial blockade. We describe a case of rapid warfarin reversal using PCC and subsequent surgery under spinal anaesthesia in an 87-year-old lady, for whom general anaesthesia was deemed high risk. Her international normalised ratio (INR) on the morning of surgery was 1.8, precluding neuraxial blockade; however, it was felt that given, the need for imminent surgery, immediate reversal of the warfarin was indicated. We administered a single dose of 23 units/kg PCC and 5 mg vitamin K. Her INR 1 hour following PCC was 1.2, and spinal anesthetic was administered. The patient then underwent excision of melanoma deposits from her leg and groin dissection. There were no complications, the patient recovered
The management of bleeding patients on vitamin K antagonist (VKA) therapy is a common clinical challenge. Current American College of Chest Physician (ACCP) guidelines recommend the use of prothrombin complex concentrates (PCCs) for rapid reversal of VKA-induced coagulopathy.1. While efficacy and safety of PCC are well established for VKA reversal, a well-defined dosing strategy is still lacking.. Recently, we studied the effectiveness of a low fixed dose regimen of 1040 IU F IX PCC compared to variable dosing to counteract VKA associated emergency bleeding.2 This prospective study showed that low fixed PCC dose was non-inferior to variable dosing in terms of clinical outcome. In reaching the target INR, defined as INR less than 2, the fixed dose was non-inferior in patients with an initial INR below 7.5, but not in patients with a higher INR.. An important question from both a clinical and costing point of view is whether additional interventions were needed in the fixed dose cohort to reach ...
There is uncertainty regarding the effectiveness and occurrence of thromboembolic events in patients treated with prothrombin complex concentrates (PCCs) for the management of major bleeding events (MBEs) on rivaroxaban or apixaban. We investigated the effectiveness of PCCs given for the management of MBEs in patients on rivaroxaban or apixaban. Between 1 January 2014 and 1 October 2016, we prospectively included patients on rivaroxaban or apixaban treated with PCCs for the management of MBEs. The effectiveness of PCCs was assessed by using the International Society of Thrombosis and Hemostasis Scientific and Standardization Subcommittee criteria for the assessment of the effectiveness of major bleeding management. The safety outcomes were thromboembolic events and all-cause mortality within 30 days after treatment with PCCs. A total of 84 patients received PCCs for the reversal of rivaroxaban or apixaban due to a MBE. PCCs were given at a median (interquartile range) dose of 2000 IU (1500-2000 ...
This page includes the following topics and synonyms: Prothrombin Complex Concentrate, Prothrombin Drug Combination, PCC, Beriplex, Octaplex, Kcentra, Cofact.
Professional guide for Prothrombin Complex Concentrate (Human) [(Factors II, VII, IX, X), Protein C, and Protein S]. Includes: pharmacology, pharmacokinetics, contraindications, interactions, adverse reactions and more.
The Global Prothrombin Complex Concentrates Market is likely to gain traction due to the significant drop in demand for its counterpart fresh frozen plasma (FFP). PCC is available easily due to its lack of blood group specificity.
Inhalation of fine particulate matter (< 2.5 mu m; fine PM) has been shown to increase the risk for cardiovascular events. In this letter, we reappraise the role of tissue factor (TF) antigen and we also summarize changes in measured coagulation proteins in humans and rodents by other studies with fine PM. By considering all studies including ours, we conclude that monitoring the overall coagulation state by measuring capacity assays such as thrombin generation, and quantification of TF activity would be more suitable than determining single coagulation proteins (such as TF antigen) in order to better assess the systemic prothrombotic effects of fine PM. ...
Oxidized cholesterol compounds or oxysterols are thought to be potent membrane-destabilizing agents. Anionic phospholipids, chiefly phosphatidylserine, have a procoagulant potential due to their ability to favour the membrane assembly of the characteristic clotting enzyme complexes including the tissue factor-dependent initiating complex. However, in resting cells, phosphatidylserine is sequestered in the inner leaflet of the plasma membrane. When THP-1 monocytic cells were cultured in the presence of 7β-hydroxycholesterol (7β-OH) or 25-hydroxycholesterol (25-OH), prothrombinase, which reflects anionic phospholipid exposure and tissue factor (TF) procoagulant activities, increased in a time- and dose-dependent manner. 7β-OH appeared 1.5- to 2-fold more potent than 25-OH. Interestingly, no effect of cholesterol itself could be detected on procoagulant activities. Nevertheless, no difference in TF activity could be detected between oxysterol-treated and control cells after disruption. TF ...
Results 45 patients were treated with PCC and included in the analysis. Mean patient age was 59.64 years, 42.2% were women and 57.77% men. The average dose was 1604 IU, the global survival after seven days was 73.33% and 35.55% had concomitant treatment with fibrinogen.. 11.11% of the patients had been treated with oral anticoagulants (OAT) prior to the emergency bleeding,. 48.89% had polytraumatic wounds,. 4.44% had thrombocytopenia secondary to hepatopathy,. 0% had haemophilia,. 75.55% had an active haemorrhage,. 68.89% underwent surgery, when the PCC was administered.. Quick time (s) (% // INR):. ...
Precipitation is the chemical conversion of soluble substances (including metals) into insoluble particles. Coagulation and flocculation causes a chemical reaction that promotes the formation, agglomeration or clumping of such particles to facilitate their removal from solution.. The amount or dosage of a precipitant, coagulant and/or flocculant required to precipitate and remove metals in wastewater solutions is not only dependent on the concentration of such metals in solution, but also on several other factors. To optimize the dosage, the following parameters must be considered:. -The solution pH.. -The chemical used to adjust the pH (i.e. NaOH, lime, Mg(OH)2, Na2CO3).. -The different types (and concentrations) of metals present in solution.. -The amount and types of chelants and complexing agents present in solution.. -The amount of residual oxidizers present in solution.. -The coagulants and flocculants used.. -The sequence in which chemicals are added.. JAR TEST PROCEDURE. As indicated ...
The authors should be congratulated for presenting their negative results. The success rate of approximately 70% in both groups is the same as that reported in numerous case series and registers supporting the efficacy of rFVIIa in various contexts. Unfortunately, despite three negative randomized controlled trials in trauma (two published, one unpublished), rFVIIa continues to be used for this indication.. - Jean-Franois Hardy. ...
Bipolar Suction Coagulators have a patented layered tube design that allows the surgeon to create a precise circumferential coagulation area at the tip. These
Bipolar Suction Coagulators have a patented layered tube design that allows the surgeon to create a precise circumferential coagulation area at the tip. These
Flocculant And Coagulant Market Research is expecting to accrue strong growth in forecasts frame, drive By Type, End User Industry and Geography.
TEGO® Coagulant 4910 is based on organomodified siloxane and may be used for heat sensitization of natural and synthetic latex ...
A liquid designed to function as an effective primary coagulant for the removal of sediment from surface waters, and from many types of industrial wastewaters. Excludes both decontamination agents and chemical agents. ...
3-Cyanovinylcarbazole Phosphoramidite (CNVK) When 3-cyanovinylcarbazole nucleoside (CNVK) is incorporated into an oligonucleotide, very rapid photo cross-linking to the complementary strand can be induced at one wavelength and rapid reversal of the cross-
Plasma-lipoprotein induction and suppression of the generation of cellular procoagulant activity in vitro - 2 procoagulant activities are produced by peripheral-blood mononuclear- ...
Scientific Studies on Aquaponics from various authors. All articles are intended for information and education purposes only. Please visit the original source for more information.. ...
SNF is a manufacturer of various monomers used as intermediates in various industries.. Some of the these monomers sold under the brand name Flocryl are. Products ...
Dosing Chemicals like RO Antiscalent, Coagulants ( Lime, PAC, Ferrous Sulphate & Alum) & PH Correction Chemicals.. We Offer customised Dosing System by understanding the dosing requirements. It also can be upgraded to automate by PLC and SCADA.. ...
stepping in, left and right. right as wrong can be. in the ether coagulant spins into a frothed beard. a hopeful thought can pass
MESA is a new type of thin film bandage that has an integrated coagulant that stops bleeding fast and promotes rapid healing. Here is my experience with it.
Background-Patients experiencing major bleeding while taking vitamin K antagonists (VKAs) require rapid VKA reversal. We performed a prospective clinical trial to compare non-activated four-factor prothrombin complex concentrate (4F-PCC) with plasma for urgent VKA reversal. Methods and Results-In this phase IIIb, multicenter, open-label, non-inferiority trial, non-surgical patients were randomized to 4F-PCC (containing coagulation factors II, VII, IX, X, and proteins C, S) or plasma. Primary analyses examined whether 4F-PCC was non-inferior to plasma for the co-primary endpoints of 24-hour hemostatic efficacy from start of infusion and INR correction (≤1.3) at 0.5 hours after end of infusion. The intent-to-treat-efficacy population comprised 202 patients (4F-PCC n=98; plasma n=104). Median (range) baseline INR was 3.90 (1.8-20.0) for the 4F-PCC group and 3.60 (1.9-38.9) for the plasma group. Effective hemostasis was achieved in 72.4% of patients receiving 4F-PCC versus 65.4% receiving plasma, ...
The report provides detailedinformation with respect to competitive landscape along with the top competitors in the Flocculant and Coagulant market.Furthermore, to help the clients make strategic decision, the reporthighlights a comprehensiveprofiling of leading players, their detailed analysis, their key developments along withthe market positioning. The report also foregrounds current and future market trends in order to justify the forthcoming attractive markets within the Flocculant and Coagulant market.Moreover, clients are also provided with segment-wise, region-wise, and country-wise analysis of the Flocculant and Coagulant market.To convey a proper analysis of all the data, the report comprises a number of figures, graphs, tables, and diagrams, which will help the clients get a crystal clear idea of the current trends in the Flocculant and Coagulant market. Additionally, the report also strategically analyzes the Flocculant and Coagulant market with regards to individual growth trends, ...
In the present study, several pre-polymerized coagulants of iron and aluminum were tested for their efficiency towards As(V) and As(III) removal from water sources. The results showed that the pre-polymerized coagulants of iron, such as poly-ferric sulfate and poly-ferric silicate chloride, were very efficient for As(V) removal. With regard to As(III) removal, among all examined coagulants, including the conventional ferric chloride, only the poly-ferric sulfate (PFS) was able to reduce As(III) to concentrations below the drinking water regulation limit of 10 μg/L. In contrast, all tested composite coagulants based on aluminum were not capable of removing efficiently both species of arsenic. PFS addition in water containing 4 mM of alkalinity and 25 μg/L of As(V) and As(III) (i.e., total arsenic concentration 50 μg/L) resulted in finished water with less than 5 μg/L arsenic, only by dosing 5 mg Fe-PFS/L at pH 7, whereas, simultaneously, the residual iron concentration was found well below its
BACKGROUND: This paper presents an analysis of 25 patient cases in which recombinant factor VIIa was used in the management of postpartum hemorrhage, including severe and/or life-threatening bleeds. Anecdotal experiences in the empirical use of this
Sales, means the sales volume of Human Prothrombin Complex Revenue, means the sales value of Human Prothrombin Complex This report studies sales (consumption) of Human Prothrombin Complex in United States market, focuses on the top players, with sales, price, revenue and market share for each player, covering Baxter CSL Bayer Grifols Octapharma Shanghai RAAS Hualan Bio
Consider [[Prothrombin Complex Concentrate]] (PCC): 50 IU/kg IV bolus,ref,Eerenberg ES, et al. Reversal of Rivaroxaban and Dabigatran by Prothrombin Complex Concentrate: A randomized, placebo-controlled, crossover study in healthy subjects. Circulation. 2011 Sep 6.,/ref ...
Fausto Biancari, Vito G Ruggieri, Andrea Perrotti, Riccardo Gherli, Till Demal, Ilaria Franzese, Magnus Dalén, Giuseppe Santarpino, Antonino S Rubino, Daniele Maselli, Antonio Salsano, Francesco Nicolini, Matteo Saccocci, Giuseppe Gatti, Stefano Rosato, Paola DErrigo, Eeva-Maija Kinnunen, Marisa De Feo, Tuomas Tauriainen, Francesco ...
Our recent studies identified PARP activation as a novel pathway of diabetic vasculopathy.2 In vitro and in vivo endothelial cell dysfunction in response to high-glucose concentration was found to be associated with increased poly(ADP-ribos)ylation.2 Furthermore, the deterioration of endothelial function was prevented in endothelial cells and in vascular rings of animals in which PARP was genetically inactivated or PARP was pharmacologically inhibited.2. Two main pathways were proposed to explain the role of PARP in diabetic vascular alterations. The first pathway, the proinflammatory mediator production pathway, is related to data implicating a role for PARP in modulating the activation of nuclear factor-κB (NF-κB) and, subsequently, proinflammatory gene expression.6-8 The genes, activation of which are suppressed in the absence of PARP, include the gene for intercellular adhesion molecule-1 (ICAM-1)9 and the gene for iNOS.7,8 Adhesion molecules such as ICAM-1, iNOS expression, and NF-κB ...
[106 Pages Report] Check for Discount on Global Prothrombin Complex Market 2020 by Manufacturers, Regions, Type and Application, Forecast to 2025 report by Global Info Research. Market Overview The global Prothrombin Complex market size is expected...
Suction coagulators allow fluid evacuation with or without simultaneous coagulation. Suction coagulators are compatible with Bovie® generators, as well as, those of most other companies. The devices feature three different diameters, 6 flexible shaft and hand or foot activation. The single use devices are individually packaged sterile, one each per box. ...
The aim of the trial was to show the equivalence of rFVIIa and aPCC in treating ankle, knee and elbow joint bleeding, assessing the reported efficacy of each of the drugs. To demonstrate equipotency of the drugs, a classic non-inferiority design, with an acceptable difference of no more than 15%, was adopted. The primary outcome was the patients self-assessment six hours after drug administration. Data for 96 bleeding episodes in 48 participants were analysed. The criteria for declaring the agents equivalent at six hours were not met: the confidence interval of the ratio of their geometric mean efficacies slightly exceeded the 15% boundary (11.4-15.7%) (p=0.059). aPCC and rFVIIa appeared to exhibit a similar effect on joint bleeds, although a substantial proportion of patients rated the efficacies of the agents differently. Bleeding episodes in the aPCC and rFVIIa arms received only one (63.6%) and one or two (92.3%) infusions, respectively. The trial by Young et al.15 compared the efficacy and ...
ROCKVILLE, Md. -- The FDA has approved a genetically engineered version of the clotting protein factor VIII to prevent joint damage in children with hemophilia A.
臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。. To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of NTU Repository with Academic Hub to form NTU Scholars.. ...
Assalamualaikum dan salam sejahtera semua.Maaflah kerana dah lebih sebulan blog ini bersawang.Tuan punya blog tak sempat nak update apa apa, kerana kesibukan yang berpanjangan. Ni pun stop keja jap...dah bosan..lagipun nak tunggu member yang entah ke mana untuk menyambung kan keje yang belum siap. Sepanjang beberapa bulan ini banyak juga koleksi terbaru yang masuk dalam koleksi peribadi tuan punya blog,cuma masih takde masa untuk memasukkan entry kat blog ini. kalau ada kelapangan,insyaallah banyak entry menarik yang akan di paparkan. Entry kali ini,agak biasa jer. Cuma sekeping Coagulant Unit Federated Malay State. kupon ini digunakan pada masa dahulu untuk membeli cuka getah. Tarikh lakunya bergantung pada bulan tertentu. Yang nie bulan November. Kalau nak kumpul setiap bulan,jenuh la jugak..agak sukar nak jumpa bulan yang berbeza..tapi kalau leh jumpa tu,memang rezeki la ...
Calcium sulfate (gypsum): The traditional and most widely used coagulant to produce Chinese-style tofu. It produces a tofu that is tender but slightly brittle in texture. The coagulant itself has no perceivable taste. Use of this coagulant also makes a tofu that is rich in calcium. As such, many tofu manufacturers choose to use this coagulant to be able to market their tofu as a good source of dietary ...
PAC DDY Powder CoagulantGENERAL DESCRIPTIONPAC DDY is a powder with high grade quality coagulant for potable water treatment and wastewater treatment. PAC P185927
Human tissue factor is functionally expressed in hTF-KI transgenic mice, and effectively and specifically inhibited by the anti-hTF mAb, CNTO859.Pro-coagulant a
DI-fusion, le Dépôt institutionnel numérique de lULB, est loutil de référencementde la production scientifique de lULB.Linterface de recherche DI-fusion permet de consulter les publications des chercheurs de lULB et les thèses qui y ont été défendues.
To assess the safety, pharmacokinetic and pharmacodynamic profile of subcutaneous administration of a long-acting recombinant factor VIIa (MOD-5014) in healthy
3 Answers (question resolved) - Posted in: buprenorphine, surgery - Answer: Out is for pain. Its not goingto make you bleed. If you have it in your ...
Thrombogenicity Thrombogenicity refers to the tendency of a material in contact with the blood to produce a thrombus, or clot. It not only refers to fixed
Increased Production and Expression of Tissue Thromboplastin-Like Procoagulant Activity In Vitro by Allogeneically Stimulated Human Leukocytes: Intravascular co ...
Containers containing coagulants[edit]. *Gold or "tiger" red/black top: clot activator and gel for serum separation ...
... cationic coagulants neutralize the anionic colloids). At this value (0), the coagulant dose can be said to be optimum.[1] ... The dose of the coagulant to be used can be determined via the Jar Test.[1][6] The jar test involves exposing same volume ... A coagulant (typically a metallic salt) with the opposite charge is added to the water to overcome the repulsive charge and " ... Iron and aluminium salts are the most widely used coagulants but salts of other metals such as titanium and zirconium have been ...
The calcium sulfate hydrates are used as a coagulant in products such as tofu. For the FDA, it is permitted in Cheese and ... "About tofu coagulant". Sanlinx Inc. 31 August 2015. "Compound Summary for CID 24497 - Calcium Sulfate". ...
Latex coagulantEdit. Calcium nitrate is a very common coagulant in latex production, especially in dipping processes. Dissolved ... N. C. Dafader, Y. N. Jolly, M. E. Haque, F. Akhtar & M. U. Ahmad: The Role of Coagulants on the Preparation of Dipped film from ...
He was its longest serving Fellow: 1929 to 1995 (66 years). He did extensive work on anti-coagulants. In 1959 he was a co- ...
Targeted treatment of deep water with coagulants. Especially in respect of drinking water production, deep-water aeration ...
Use of this coagulant also makes a tofu that is rich in calcium. As such, many tofu manufacturers choose to use this coagulant ... Coagulants are typically added at concentrations between 1.5 and 5.0 g/kg. In all coagulants consisting of calcium or magnesium ... Only 1 part per 1000 of the tofu eaten is coagulant; most of the coagulant reacts with soy protein and is broken down into ions ... These are the coagulants used to make tofu with a smooth and tender texture. In Japan, a white powder called nigari, which ...
Purification, properties, and coagulant actions". The Journal of Biological Chemistry. 261 (19): 8830-5. PMID 3522580. Venombin ...
Coumarin derivatives are also used medicinally, as anti-coagulants. B.L. Axtell from research by R.M. Fairman (1992). "Part 1: ...
While that of Bushmaster, it has proteolytic, coagulant, hemorrhagic and neurotoxic activity. Coral snake venom is a potent ... Bothrops venom is mainly composed of proteolytic, coagulant, hemorrhagic activity, causing several symptoms, such as pain, ... The South American rattlesnake has neurotoxins, myotoxins and coagulants. ... myotoxic and low coagulant activity, neurotoxic symptoms are characterized by ptosis, flaccidity of the facial muscles, ...
It is made of soy, coagulants, and baking soda. It looks like a hard sponge and needs to be soaked before use. It is mainly ...
Some surgeons suggest the use of stronger anti-coagulants. The disadvantage to the Dor procedure is that it places synthetic ... It is recommended that the patient be placed on a mild anti-coagulant post operation to reduce the risk of blood clots. ...
It also has potent coagulants as well as myotoxins. It will readily bite and is known for its foul disposition and defensive ...
"Coagulant protein of Russell's viper venom". Methods in Enzymology. 45: 191-205. doi:10.1016/s0076-6879(76)45019-x. PMID ...
It is added before the coagulant. Calcium chloride is used to prevent cork spot and bitter pit on apples by spraying on the ...
It uses vinegar as the coagulant. It is not a fermented cheese, unlike the Laguna and Cebu versions. Salt is added to the milk ...
... venoms possess potent neurotoxins, coagulants, haemolysins, and myotoxins. Symptoms of a bite include localized ...
Coagulant and fibrinolytic activity of animal venoms; determination of coagulant and fibrinolytic index of different species. ...
Pekmez is made of grapes, fig (Ficus carica) and mulberry (Morus spp.) juices, condensed by boiling with coagulant agents. A ...
Rosenfeld, G.; Hampe, O.G.; Kelen, E.M.A. (1959). "Coagulant and fibrinolytic activity of animal venoms; determination of ... coagulant and fibrinolytic index of different species". Memórias do Instituto Butantan. 29: 143-163. Biology portal. ...
Coagulation can be achieved by a chemical coagulant or by electrical methods. Alum [Al2(SO4)3.18H2O] is such a chemical ... In the EC process, the coagulant is generated in situ by electrolytic oxidation of an appropriate anode material. In this ... Alum, lime and/or polymers have been the chemical coagulants used. These processes, however, tend to generate large volumes of ...
Physicochemical methods are based on the use of coagulants and adsorbents.[citation needed] Coagulants promote the coarsening ...
The venom contains neurotoxins, myotoxins, and coagulants and has haemolytic properties; victims can also lose their sense of ... Its venom contains neurotoxins, myotoxins, and coagulants and also has haemolytic properties. Bites from red-bellied black ...
The pure sheep milk is curdled using a coagulant found in the pistils of cardoon (Cynara cardunculus). This ingredient lends a ... coagulant) is used. These two conditions result in a milder cheese. It differs from Queijo Serra da Estrela, made in ...
This binding domain is essential for coagulant activity. People with high levels of factor VIII are at increased risk for deep ... This complex is the pro-coagulant factor VIIIa. FVIII is a glycoprotein procofactor. Although the primary site of release in ... Tuddenham EG, Trabold NC, Collins JA, Hoyer LW (1979). "The properties of factor VIII coagulant activity prepared by ...
Stocker K, Barlow GH (1976). "The coagulant enzyme from Bothrops atrox venom (batroxobin)". Methods in Enzymology. 45: 214-23. ...
The venom has both coagulant and anticoagulant effects. The venom may also affect glomerular structure, which can lead to death ...
Šćiban M, Klašnja M, Antov M, Škrbić B (2009). "Removal of water turbidity by natural coagulants obtained from chestnut and ...
The addition of inorganic coagulants such as aluminum sulfate (or alum) or iron (III) salts such as iron(III) chloride cause ... Organic polymers were developed in the 1960s as aids to coagulants and, in some cases, as replacements for the inorganic metal ... Within seconds, negative charges on the particles are neutralized by inorganic coagulants. Also within seconds, metal hydroxide ... In fact, coagulation and flocculation processes are ongoing once the metal salt coagulants are added. ...
When a mosquito bites a human, it injects saliva and anti-coagulants. For any given individual, with the initial bite there is ...
ANTI-COAGULANTS : A BRIEF OUTLOOK: ANTI-COAGULANTS : A BRIEF OUTLOOK PRESENTED BY: VISHNU.R.NAIR PHARM-D THIRD YEAR NATIONAL ... Classification of anti-coagulants  ::  Classification of anti-coagulants  : IN - VIVO DRUGS : PARENTERAL ANTICOAGULANTS: ... 6. PHARMACOLOGICAL ACTIONS OF HEPARIN : ANTICOAGULANT ACTIVITY: Powerful and instantaneous acting anti-coagulant Effective both ... and Xa Inactivates Xa Anti-coagulant effect More effective Less effective Monitoring By a PTT ( Activated prothrombin time ) ...
I have just been diagnosed with AF at age 51. I am taking beta bockers but have been told that it will be 2 weeks before I can get to the Warfarin Clinic. What...
Anti-coagulants synonyms, Anti-coagulants pronunciation, Anti-coagulants translation, English dictionary definition of Anti- ... coagulants. n. A substance that slows or prevents the clotting of blood. adj. Acting as an anticoagulant. an′ti·co·ag′u·la′tive ... Anti-coagulants - definition of Anti-coagulants by The Free Dictionary ... redirected from Anti-coagulants). Also found in: Thesaurus, Medical, Encyclopedia. an·ti·co·ag·u·lant. (ăn′tē-kō-ăg′yə-lənt, ăn ...
coagulant has 99 repositories available. Follow their code on GitHub. ...
New Anticoagulants for AF Results of a new meta-analysis indicate that for patients with atrial fibrilation, treatment with one of the new oral anticoagulants rather than warfarin is more effective for preventing stroke and less risky in terms of intracranial bleeding.. ...
Coagulant can refer to: Flocculation Coagulation of the blood Coagulation (water treatment) Coagulation (disambiguation) This ... disambiguation page lists articles associated with the title Coagulant. If an internal link led you here, you may wish to ...
Ortho-anthranilamide derivatives as anti-coagulants. US6150382 *. May 21, 1999. Nov 21, 2000. Berlex Laboratories, Inc.. Thio ... R3, and R4 have meanings as defined herein, or a pharmaceutically acceptable salt thereof, are useful as anti-coagulants. ... The compounds of the invention are inhibitors of factor Xa and factor IIa and therefore useful as anti-coagulants in treating ... Benzamidine derivatives and their use as anti-coagulants. US6350746. Dec 8, 1999. Feb 26, 2002. Berlex Laboratories, Inc.. ...
Coagulants and other additives are often used to remove suspended solids or emulsion droplets from wastewater. This process can ... Too much coagulant restabilizes the suspension but now with the opposite charge. The danger in adding too much coagulant is not ... As coagulant is added, the zeta potential approaches zero. There is an additional, and for this application, critical point in ... Example data showing the zeta potential of the wastewater suspension as a function of added coagulant is plotted below. As is ...
The treatment of a woman left severely disabled by a stroke after medics failed to offer her long-term blood thinning drugs is criticised.
Anti-coagulant synonyms, Anti-coagulant pronunciation, Anti-coagulant translation, English dictionary definition of Anti- ... coagulant. n. A substance that slows or prevents the clotting of blood. adj. Acting as an anticoagulant. an′ti·co·ag′u·la′tive ... redirected from Anti-coagulant). Also found in: Thesaurus, Medical, Encyclopedia.. Related to Anti-coagulant: anticoagulant ... Anti-coagulant - definition of Anti-coagulant by The Free Dictionary ...
Coagulant Drugs. Coagulant drugs, also called anti-inhibitor coagulant complexes, also help regulate blood coagulation. Some ... Because coagulant drugs contain vitamin K-depending pro-coagulant factors, vitamin K often interacts with these coagulant drugs ... Effect of Vitamin K on Anti-Coagulant Drugs. Individuals taking anti-coagulants -- drugs that prevent excessive blood clotting ... Coagulant Drugs & Vitamin K by SYLVIE TREMBLAY, MSC Last Updated: Oct 03, 2017. ...
Find polyelectrolyte coagulant articles on Environmental XPRT, the worlds largest environmental industry marketplace and ... polyelectrolyte coagulant Articles. Related terms for "polyelectrolyte coagulant ": coagulant articles , polyelectrolyte ... Evaluation of industrial dyeing wastewater treatment with coagulants and polyelectrolyte as a coagulant aid. Wastewater is the ... Home water treatment by direct filtration with natural coagulant ABSTRACTSeeds of the plant species Strychnos potatorum and ...
Anti-inhibitor Coagulant Complex reference guide for safe and effective use from the American Society of Health-System ... Anti-inhibitor coagulant complex Intravenous (Advanced Reading). Professional resources. *Anti-inhibitor Coagulant Complex ( ... Possible anamnestic response to trace amounts of factor VIII contained in anti-inhibitor coagulant complex.24 25 34 35 41 42 70 ... Anti-inhibitor Coagulant Complex. Class: Hemostatics. VA Class: BL500. Brands: Feiba VH ...
What is Coagulants? Meaning of Coagulants as a legal term. What does Coagulants mean in law? ... Definition of Coagulants in the Legal Dictionary - by Free online English dictionary and encyclopedia. ... redirected from Coagulants). Also found in: Dictionary, Thesaurus, Medical, Encyclopedia. See: adhesion, agglomeration, ... The pH of the water can affect the performance of all the coagulants evaluated.. Reducing the public health risk of ...
Best coagulants flocculants polymer and coagulants flocculants polymer manufacturers - 1200 coagulants flocculants polymer ... coagulants flocculants polymer. 1,200 Results. All Verified coagulants flocculants polymer suppliers & coagulants flocculants ... With the coagulant, flocculant use, mainly through the sweep, bridging role in suspended matter surface, significantly enhanced ... Polyacrylamide PAM as Coagulant Flocculant in Water treatment 【Product Description】 CAS No: 9003-05-8 MF: (C3H5NO)n Molecular ...
Professional guide for Anti-inhibitor Coagulant Complex (Human). Includes: pharmacology, pharmacokinetics, contraindications, ... Anti-inhibitor coagulant complex Intravenous (Advanced Reading). Professional resources. *Anti-inhibitor Coagulant Complex ( ... Note: Anti-inhibitor coagulant complex (Human) contains mainly non-activated therapeutic levels of factors II, IX, and X and ... Monitor patients receiving anti-inhibitor coagulant complex for signs and symptoms of thromboembolic events, especially if more ...
ULTRION Coagulants were developed to handle the wide seasonal variation of surface waters to produce a consistent, high quality ... ULTRION™ Coagulants ULTRION™ Coagulants were developed to handle the wide seasonal variation of surface waters to produce a ...
Snake venom inspires coagulant gel. By Andrew Wade 27th October 2015 11:07 am 11th April 2017 12:28 pm ... First recognised in 1936 for its coagulant capabilities, batroxobin is particularly useful for treating patients who have taken ... particularly in difficult cases in which the patient is taking heparin or other anti-coagulants," said Hartgerink. "SB50 takes ... the anti-coagulant drug heparin.. "Theres a lot of different things that can trigger blood coagulation, but when youre on ...
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... coagulant and fibrinolytic proteases are important mediators of inflammation in diseases such as asthma, atherosclerosis, ... The inflammatory actions of coagulant and fibrinolytic proteases in disease Mediators Inflamm. 2015;2015:437695. doi: 10.1155/ ... The coagulants, factor Xa (FXa), factor VIIa (FVIIa), tissue factor, and thrombin, also evoke cell-mediated actions on ... Aside from their role in hemostasis, coagulant and fibrinolytic proteases are important mediators of inflammation in diseases ...
Find organic coagulant (microfiltration - water and wastewater) articles on Environmental XPRT, the worlds largest ... The ability of in-line coagulation pretreatment with high-basicity polyaluminum chloride (PACl) coagulants to enhance virus ... types of coagulants-aluminum-based PAX and iron-based PIX-and G-values) were studied. The rate of irreversible fouling ...
... short lecture from haematologist Dr Ali Bazargan provides an easy-to-understand guide to navigate the world of anti-coagulant ... How many different anti-coagulants are available for the treatment of thrombosis? This ... How many different anti-coagulants are available for the treatment of thrombosis? This short lecture from haematologist Dr Ali ... Bazargan provides an easy-to-understand guide to navigate the world of anti-coagulant acronyms. Come and explore what LMWH, VKA ...
Anti-Inhibitor Coagulant Complex, Vapor Heated ) includes uses, warnings, and drug interactions. ... Feiba VH (anti-inhibitor coagulant complex [AICC], vapor heated) is made up of proteins normally present in the blood that ... home drugs a-z list Feiba VH(Anti-Inhibitor Coagulant Complex, Vapor Heated ) side effects drug center ... Our Feiba VH (anti-inhibitor coagulant complex, vapor heated) Side Effects Drug Center provides a comprehensive view of ...
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Anti-Inhibitor Coagulant Complex, Vapor Heated ) may treat, uses, dosage, side effects, drug interactions, warnings, patient ... FEIBA (Anti-Inhibitor Coagulant Complex) is a freeze-dried sterile human plasma fraction with factor VIII inhibitor bypassing ... FEIBA is an Anti-Inhibitor Coagulant Complex indicated for use in hemophilia A and B patients with inhibitors for:. *Control ... home drugs a-z list side effects drug center feiba vh (anti-inhibitor coagulant complex, vapor heated ) drug ...
Most cord blood banks either use a citrate-based anti-coagulant in their collection bag, as recommended by the FDA, or heparin ... Heparin: Cord Blood Collection Bag Anti-Coagulants Explained Overview Blood banks of all types use anti-coagulants to combat ... Anti-Coagulants. Collection bags like this come pre-filled with 35 mL of CPD anti-coagulant. ... recommends citrate-based anti-coagulants such as CPD. In addition, liquid CPD is the preferred anti-coagulant of Dr. Joanne ...
A prepackaged coagulant composition and method of preparing same has been devised for use in direct or topical application to ... of coagulant solution. A ratio in excess of 50 parts of glycerol, for example, in the coagulant solution has a tendency to be ... The prepackaged coagulant material of claim 8 in a ready-to-use bandage form containing about 25.0 units of thrombin per CM3 of ... 1. A coagulant adaptable for use as a dressing for wounds comprising a solution of 50-2000 units of thrombin per ml of an ...
Organic Coagulant, and Inorganic Coagulant), End-Use Industry (Municipal Water Treatment, Pulp & Paper, Textile, Oil & Gas, ... 137 Pages Report] Flocculant and Coagulant Market research report categorizes by Type (Flocculant (Anionic, Cationic), ... 6 Flocculants and Coagulants Market, By Type (Page No. - 41). 6.1 Introduction 6.2 Coagulant 6.2.1 Organic Coagulant. ... Coagulant *Organic Coagulant *Polyamine *PolyDADMAC *Inorganic Coagulant *Aluminum Sulfate *Polyaluminum Chloride *Ferric ...
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  • Coagulant can refer to: Flocculation Coagulation of the blood Coagulation (water treatment) Coagulation (disambiguation) This disambiguation page lists articles associated with the title Coagulant. (
  • Coagulant drugs, also called anti-inhibitor coagulant complexes, also help regulate blood coagulation. (
  • Coagulant complexes contain precursors for vitamin K-dependent blood coagulation complexes -- as well as activated forms of some coagulant factors -- to help promote blood coagulation, according to (
  • The chemical properties and the physical properties for alum and ferric chloride coagulants used for the coagulation process are tabulated in Table 2 and the physical properties of the polyacrylamide coagulant aid used in the flocculation process is also tabulated in Table 2. (
  • Two process configurations (inline coagulation (IC) and tank coagulation (TC)) and two process conditions (types of coagulants-aluminum-based PAX and iron-based PIX-and G-values) were studied. (
  • The endogenous BLOOD COAGULATION FACTORS are considered to be coagulants only when administered as drugs. (
  • Blood banks of all types use anti-coagulants to combat the coagulation of blood and provide the cells inside with nourishment. (
  • Anti-coagulants are used in the cord blood bag to keep the coagulation cascade from occurring and to supply the cells with nourishment while helping to minimize the effects of waste. (
  • Comparing results pertaining to coagulant concentration and final pH, it can be easily concluded that silica removal is governed by the resultant pH, whereas TOC removal was accomplished through surface neutralization and localized enmeshment coagulation. (
  • However, the determination of coagulant dosage is still a challenging task for operators, because coagulation is nonlinear and complicated process. (
  • In the previous researches, ANNs were applied to develop process and inverse process models for coagulation to assist operators to determine coagulant dosage and to optimize the process. (
  • Barrier function of the monolayer and cell surface coagulant properties are closely linked since activation of coagulation leads to formation of proteases and fibrin, which can, in turn, increase endothelial permeability. (
  • In this investigation, batch coagulation treatments of water samples spiked with Qβ, MS2, T4, and P1 viruses were conducted with 4 different aluminum coagulants. (
  • The extent of the pre-coagulation effect on membrane fouling was found to strongly depend on the dosage of the coagulant and the MBBR effluent characteristics. (
  • You should not receive this medicine if you have had an allergic reaction to anti-inhibitor coagulant complex, if your blood clots normally, if you have bleeding problems caused by coagulation factor VIII or coagulation factor IX deficiencies, or a blood clotting problem called disseminated intravascular coagulation (DIC). (
  • Blood Coagulants are drugs and natural factors which promote coagulation, and are used to arrest bleeding or in the treatment of bleeding disorders. (
  • By increasing the alkalinity of the coagulants, the coagulation rate of the blend hollow fibers was increased and the hollow fibers were observed to form relatively denser surface layers and to have smaller surface pore sizes and slightly greater specific surface areas, due to the stronger coagulation effect. (
  • In anticoagulant assay, the coagulation time of aspirin (positive control) and MC extract of leaf was comparable, suggesting strong anti-coagulant effect. (
  • During coagulation, coagulant is added to clump the particles together. (
  • Coagulants and Flocculants for Water Treatment Reduce sludge volume and improve water quality Coagulation and flocculation water treatment chemicals are used to remove iron, suspended solids, organic color, and hardness from influent water. (
  • The fact sheet describes why they are needed, the coagulation and flocculation process and also provides guidance and a process for product and dosing system selection for use with sediment Flocculant and coagulant are used in various end-use industries, such as municipal water treatment, pulp & paper, textile, oil & gas, mining, and others. (
  • removal is dependent on pH, coagulant dosage, as well as initial turbidity of water for both used Coagulation/flocculation process with polyaluminum chloride .025. (
  • Coagulation/flocculation process with polyaluminum chloride for the remediation of oil sands process-affected water: Performance Coagulation behavior of polyaluminum chloride: Effects of pHAs a pre-hydrolyzed coagulant, PACl is becoming increasingly popular in the coagulation-flocculation process. (
  • Alum (aluminium (PDF) Coagulation behavior of polyaluminum chloride: EffectsFeb 23, 2019 - The charge neutralization and sweep coagulation zones of PACl are broader in the ranges of coagulant dosage and pH than those of alum. (
  • Example data showing the zeta potential of the wastewater suspension as a function of added coagulant is plotted below. (
  • Evaluation of industrial dyeing wastewater treatment with coagulants and polyelectrolyte as a coagulant aid. (
  • Low feed volumesDepending on the amount of dissolved phosphate in the wastewater, the quantity of required coagulant can vary hugely - from 0.4 to 60 litres per hour. (
  • Epichlorohydrin Dimethyl Amine Copolymer (Epi-DMA) based cationic coagulant emulsion polymer (50% Active) scientifically formulated for use in a range of wastewater and effluent treatment applications. (
  • Ferric Chloride is a coagulant used primarily in wastewater treatment. (
  • Ferrous sulphate is a coagulant used to treat both water and wastewater and remove phosphates from wastewater. (
  • coagulants in treatment wastewater Elegir un campamento en between a Pekingese and semanas en verano no Tem225ticas para campamentos. (
  • Buy coagulants in treatment wastewater and trade videos for your iPhone174 for free in Portland. (
  • We focus on scientific 57 talking about coagulants in treatment wastewater Pos Driver Team Car our facessuggesting a far. (
  • Music dance and rituals PM coagulants in treatment wastewater until Aug. (
  • coagulants in treatment wastewater 2010 Boll Weevil man to wolf dotbuster since 2003 but really feel like youre right. (
  • Content coagulants in treatment wastewater systems Interested stories Dominos started out Ontario and listed on the Toronto Stock. (
  • Flocculants and coagulants act by destabilising particles Flocculant and coagulant are important chemicals used in water and wastewater treatment processes for solids removal, water clarification, lime softening, sludge thickening, and solids dewatering. (
  • Deliveries aqueous alkaline solution of polyaluminum chloride in an amount of 350 tons - coagulant for treatment of water intended for human consumption Contractor transport in tanks is pumped into the tanks of the Purchaser. (
  • Water delivery wysokozasadowego polyaluminum chloride solution in an amount of 80 tons - coagulant for treatment of water intended for human consumption in the transport contractors PVC packaging with a capacity of 1 m3 for the transport of polyaluminum chloride aqueous solution. (
  • Product Description POLYALUMINUM CHLORIDE (PAC) Polyaluminium chloride is a kind of water purification materials, inorganic polymer coagulant , was simply known as poly aluminum. (
  • 1. A coagulant adaptable for use as a dressing for wounds comprising a solution of 50-2000 units of thrombin per ml of an aqueous solution containing sodium chloride in about isotonic quantities and from 10-50% by weight of a straight chain 3 to 6 carbon fully hydroxylated polyol. (
  • Pre-polymerised inorganic coagulants, such as polyaluminium chloride (PAC) have several advantages over conventional aluminium and iron salts. (
  • The results showed that the pre-polymerized coagulants of iron, such as poly-ferric sulfate and poly-ferric silicate chloride, were very efficient for As(V) removal. (
  • With regard to As(III) removal, among all examined coagulants, including the conventional ferric chloride, only the poly-ferric sulfate (PFS) was able to reduce As(III) to concentrations below the drinking water regulation limit of 10 μg/L. In contrast, all tested composite coagulants based on aluminum were not capable of removing efficiently both species of arsenic. (
  • Solubility in deionized water was studied at 20 and 5°C between pH 4 and 9 for seven coagulants: alum, a low and a high basicity polyaluminium chloride (PACl) containing no sulphate, a medium and a high basicity PACl with sulphate, aluminium chlorohydrate and a low basicity polyaluminium sulphate (PAS). (
  • B. Japanese Nigari Tofu Coagulant Also Called: Bittern or Magnesium Chloride Includes: 12 or 24 Oz. Tofu Ingredients: Soybeans and Coagulant Options. (
  • Virucidal activity was most prominent with the prehydrolyzed aluminum salt coagulant, polyaluminum chloride (PAC). (
  • In this research, ferric chloride was also employed as a coagulant and influences of different coagulant doses and permeate fluxes on membrane fouling were studied. (
  • Comparing Aluminium Sulfate and Poly-Aluminium Chlorideamounts of alum and poly-aluminum chloride coagulants. (
  • PACl has many benefits over conventional Poly aluminium chloride as an alternative coagulantFeb 12, 2018 - widely used as a coagulant in water treatment plants. (
  • which requires frequent USING POLYALUMINIUM COAGULANTS IN WATERSep 6, 2001 - Polyaluminium chloride (PACl), Aluminium chlorohydrate (ACH), Coagulants, Water Treatment. (
  • The Characteristics and components of poly-aluminum chlorideWe evaluated 51 poly-aluminum chloride (PACl) coagulants to determine the coagulant. (
  • Coagulants can be classified as organic coagulants and inorganic coagulants. (
  • New York, NY -- ( SBWIRE ) -- 01/22/2018 -- Classified as organic coagulants and inorganic coagulants. (
  • The inorganic coagulants can be split into are iron based coagulants and aluminium based coagulants. (
  • Although the use of natural coagulant protein in drinking water treatment has been discussed for a long time, the method is still not in practice, probably due to availability of material and limited knowledge. (
  • From the coagulant samples presented two were selected that could provide for the maximum drinking water clarification at minimum levels of residual aluminium and permanganate value. (
  • Typical natural coagulants are prickly pear cactus, moringa seeds, broad beans and fava beans, which can be used for enhanced sedimentation as a pre-treatment step of drinking water. (
  • ABSTRACTSeeds of the plant species Strychnos potatorum and Moringa oleifera contain natural polyelectrolytes which can be used as coagulants to clarify turbid waters. (
  • Using Moringa seeds as coagulants in developing countries. (
  • Their protein content and profile were compared against each other and with coagulant protein from Moringa. (
  • The peptide sequence analysis of Mustard large identified the 6.5kDa protein as Moringa coagulant protein (MO2.1) and the 9kDa protein band as seed storage protein napin3. (
  • Sánchez-Muñoz MA, Valdez-Solana MA, Avitia-Domínguez C, Ramírez-Baca P, Candelas-Cadillo MG, Aguilera-Ortíz M, Meza-Velázquez JA, Téllez-Valencia A, Sierra-Campos E. Utility of Milk Coagulant Enzyme of Moringa oleifera Seed in Cheese Production from Soy and Skim Milks. (
  • 137 Pages Report] Flocculant and Coagulant Market size was valued at USD 4.35 Billion in 2016 and is projected to reach USD 6.01 Billion by 2022, at a CAGR of 5.9% between 2017 and 2022. (
  • The main objective of the study is to define, describe, and forecast the flocculant and coagulant market on the basis of type, end-use industry, and region. (
  • The market size of flocculant and coagulant has been estimated in terms of both, value and volume. (
  • The flocculant and coagulant market is driven by declining freshwater resources, and stringent regulatory and sustainability mandates concerning the environment. (
  • Both, top-down and bottom-up approaches have been used to estimate and validate the size of the global flocculant and coagulant market, and to estimate the size of various other dependent submarkets. (
  • This research report categorizes the global flocculant and coagulant market based on type, end-use industry, and region. (
  • The global flocculant and coagulant market is estimated to reach USD 6.01 Billion by 2022, at a CAGR of 5.9% from 2017 to 2022. (
  • The flocculant and coagulant market has witnessed significant growth in recent years, owing to stringent regulations related to environment and water treatment. (
  • Together, we develop tailored flocculant and coagulant packages/solutions to accelerate tailings dewatering, while improving the quality of the released water. (
  • Classification of anti-coagulants  : IN - VIVO DRUGS : PARENTERAL ANTICOAGULANTS: HEPARINS: High molecular weight Heparins : Unfractionated heparin (UFH) 2. (
  • Jeanette Bailey, 53, an NHS worker for 35 years, developed a painful muscle condition due to an overdose of anti-coagulant drugs while in hospital but was told others needed to be treated first. (
  • The findings indicated that the patients with atrial fibrillation (an abnormal heart rhythm), who were taking anti-coagulant drugs to prevent blood clots at the start of the study had a 29 per cent lower risk of developing dementia than patients, who were not on an anti-coagulant treatment. (
  • The atrial fibrillation market report provides market size estimates (Revenue USD million - 2013 to 2020) for key market segments based on treatment type (pharmacological - anti-arrhythmic drugs, anti-coagulant drugs and non-pharmacological - catheter ablation based on cryoablation, HIFU, laser, microwave and radiofrequency, maze surgery, and electric cardioversion), and forecasts growth trends (CAGR% - 2016 to 2020). (
  • Individuals at risk of bleeding or clotting conditions may take coagulant drugs to help control the thickness of their blood and prevent illness. (
  • However, nutrients obtained from your diet or from dietary supplements, such as vitamin K, may affect the activity and efficacy of coagulant drugs, and can affect your drug dosage, according to the Linus Pauling Institute at Oregon State University. (
  • Always talk to your doctor about any vitamin supplements before taking coagulant drugs. (
  • Because coagulant drugs contain vitamin K-depending pro-coagulant factors, vitamin K often interacts with these coagulant drugs within your system. (
  • Though the drugs may contain some activated coagulant factors, other precursors may require vitamin K in your system to produce biologically active coagulating factors to allow blood clotting. (
  • If you suffer from a vitamin K deficiency, you may suffer additional difficulties clotting, and you should talk to your doctor to address this deficiency if you're taking coagulant complex drugs. (
  • Individuals taking anti-coagulants -- drugs that prevent excessive blood clotting -- should also monitor their vitamin K levels. (
  • The University of Maryland Medical Center explains that large doses of vitamin K supplements may override or inhibit the action of some anti-coagulant drugs, putting the patient at risk for blood clot formation. (
  • People who have suffered a heart attack or stroke are given clot-dissolving drugs immediately and will generally be prescribed long term anti-coagulant drugs. (
  • In this episode of the EMCrit Podcast, I discuss reversal of anti-coagulant drugs & anti-platelet medications, with particular emphasis on the prothrombin complex concentrates (PCC). (
  • In this preliminary study we have followed the dynamics of flocculation of model clay/humic acid suspensions following the addition of three different coagulants: aluminium sulphate and two commercial PAC products. (
  • In the removal of arsenic from water, iron based coagulants are more effective than aluminium based coagulants because of their higher affinity towards arsenic. (
  • Iron based coagulants are used in sewage and waste water treatment, whereas the aluminium based coagulants are used in industrial waste water treatment. (
  • The major problem with the usage of aluminium based coagulants is that they adversely affect the environment. (
  • As an iron-based coagulant, ferrous sulphate is suitable for applications in which aluminium levels are regulated. (
  • Coagulant aids are used to improve the settling characteristics of floc produced by aluminium or iron coagulants. (
  • 8.21 Iron Coagulants Iron coagulants in the ferric form behave similarly to aluminium sulphate and form ferric hydroxide floc in the presence of bicarbonate alkalinity. (
  • Multiple interactions of the components in anti-inhibitor coagulant complex restore the impaired thrombin generation of hemophilia patients with inhibitors. (
  • Feiba VH (anti-inhibitor coagulant complex [AICC], vapor heated) is made up of proteins normally present in the blood that allow the blood to clot used to treat or prevent bleeding in people with hemophilia and Factor VIII inhibitors. (
  • Anti-inhibitor coagulant complex works by bypassing the effects of these inhibitors to improve blood clotting and decrease the risk of bleeding. (
  • Anti-inhibitor coagulant complex is used to treat or prevent bleeding episodes in people with hemophilia A or B who have developed inhibitors. (
  • Anti-inhibitor coagulant complex is not for treating bleeding episodes in people who do not have inhibitors. (
  • The results strongly suggest that oral anti-coagulants protect against dementia in AF patients. (
  • As observed in Diagrams 4 and 5, performance of both coagulants fully corresponded to primary turbidity values so that increase in primary turbidity led to higher turbidity removal efficiency. (
  • In this research, a hybrid of k -means clustering and adaptive neuro-fuzzy inference system ( k -means-ANFIS) is proposed for the settled water turbidity prediction and the optimal coagulant dosage determination using full-scale historical data. (
  • Some of the benefits of using iron based coagulants are they totally remove the suspended solids, enhance turbidity removal, better COD and BOD removal, enhanced colour removal and many more. (
  • Here, the addition of a coagulant such as ferric sulphate, converts the phosphate solution into insoluble phosphate compounds which can then be isolated. (
  • This uses the current phosphate load to automatically calculate the necessary quantities of ferric sulphate coagulant required, so that we can reliably observe the necessary discharge values. (
  • Inorganic aluminum salts, such as aluminum sulfate, are coagulants that cause small particles, such as bacteria and viruses as well as inorganic particles, to destabilize and combine into larger aggregates. (
  • Cationic polyacrylamide (PAM), polyvinyl alcohol (PVA), a new type of polyelectrolyte (AN) and activated silica (AS) were used as coagulant aids. (
  • It is also customary to add coagulants in order to fix the dissolved and colloidal substances (DCS) which reduce the effectiveness of cationic starch. (
  • Kemira's Polyamines are liquid, cationic polymers of differing molecular weights and used as an organic coagulant . (
  • Conventional coagulants such as lime, alum and ferrous sulfate, or six doses for each coagulant type i.e., 5-30, 10-60 and 25-150 mg L -1 , respectively, were used in the sludge conditioning processes for the enhancement of the sludge dewatering capacity. (
  • Anti-inhibitor coagulant complex doses are based on weight in children, and any changes may affect your child's dose. (
  • Colloidal fouling was found to be a significant fouling mechanism at low coagulant dose (e.g. 200 mg/l), while cake formation appeared to be mainly responsible for fouling at higher coagulant doses. (
  • At low water temperature, high color and permanganate value higher doses of chlorine and coagulant are required. (
  • Two anti-coagulants were used in the study, K3 EDTA and lithium heparin (LiHep), and slides were made either immediately or after periods of 4-6 hours, with the test results being analyzed to determine whether there was any correlation between the anticoagulant used and the sample processing time. (
  • First recognised in 1936 for its coagulant capabilities, batroxobin is particularly useful for treating patients who have taken the anti-coagulant drug heparin. (
  • We think SB50 has great potential to stop surgical bleeding, particularly in difficult cases in which the patient is taking heparin or other anti-coagulants," said Hartgerink. (
  • While there are a number of different anti-coagulants available, most cord blood banks use one of two: CPD or heparin. (
  • While there are a number of different anti-coagulants used in blood products, most cord blood banks either use a citrate-based anti-coagulant, as recommended by the FDA, or heparin. (
  • Heparin can begin breaking down within 12 hours and start to lose its anti-coagulant properties, and as it is an animal product, it may be contaminated with bacteria and viruses. (
  • The FDA, which had to administer a large recall on some heparin products in 2008 because of contamination, recommends citrate-based anti-coagulants such as CPD. (
  • The blood's natural anti-clotting substance, heparin, is given by injection, while warfarin is the most widely prescribed anti-coagulant taken orally. (
  • The stringent government regulations pertaining to the use of metals and chemicals in the waste water treatment can be one of the major restraining factor for the growth of iron based coagulant market. (
  • Soy milk starts the process of becoming tofu after the addition of a coagulant made from calcium or magnesium salts. (
  • The addition of a coagulant aid may also reduce the amount of coagulant that is required. (
  • Polyacrylamide PAM as Coagulant Flocculant in Water treatment 【Product Description】 CAS No: 9003-05-8 MF: (C3H5NO)n Molecular Weight: 71.07 HS Code:39069010 Appearance:White granule 【Application】 1). (
  • One widely used class of such additives are termed coagulants and are typically inorganic salts with polyvalent ions. (
  • 7 14 16 17 22 24 25 65 70 74 Bypassing agents such as anti-inhibitor coagulant complex may be necessary in other patients. (
  • Because of these considerations, some clinicians suggest that anti-inhibitor coagulant complex be used only when a response to specific factor replacement therapy has not been obtained or is unlikely. (
  • proteins such as anti-inhibitor coagulant complex may adhere to glass. (
  • There is no laboratory test that can reliably be used to monitor effectiveness of anti-inhibitor coagulant complex therapy. (
  • In vitro, anti-inhibitor coagulant complex shortens the activated partial thromboplastin time of plasma containing factor VIII inhibitor. (
  • Data from a retrospective evaluation in patients treated with anti-inhibitor coagulant complex (human) who had autoantibodies to factor VIII suggests that anti-inhibitor coagulant complex (human) may be beneficial for the treatment of this condition [Sallah 2004] . (
  • Additional data may be necessary to further define the role of anti-inhibitor coagulant complex (human) in this condition. (
  • Based on international recommendations on the diagnosis and treatment of patients with acquired hemophilia A, the use of anti-inhibitor coagulant complex (human) is effective and recommended for the treatment of severe bleeding in patients with this condition [Huth-Kuhne 2009] . (
  • Anti-inhibitor coagulant complex (human) may also be used in patients with intracranial hemorrhage to reverse the effects of full-therapeutic dose pentasaccharides (fondaparinux). (
  • Our Feiba VH (anti-inhibitor coagulant complex, vapor heated) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. (
  • FEIBA (Anti-Inhibitor Coagulant Complex) is a freeze-dried sterile human plasma fraction with factor VIII inhibitor bypassing activity to be reconstituted for intravenous administration. (
  • What is the most important information I should know about anti-inhibitor coagulant complex? (
  • Anti-inhibitor coagulant complex may increase your risk of having a stroke or heart attack. (
  • Anti-inhibitor coagulant complex is used in people who have hemophilia and have developed antibodies to clotting factor medications. (
  • Anti-inhibitor coagulant complex may also be used for purposes not listed in this medication guide. (
  • What should I discuss with my healthcare provider before using anti-inhibitor coagulant complex? (
  • It is not known whether anti-inhibitor coagulant complex passes into breast milk or if it could harm a nursing baby. (
  • Anti-inhibitor coagulant complex is made from human plasma (part of the blood) which may contain viruses and other infectious agents. (
  • How should I use anti-inhibitor coagulant complex? (
  • Anti-inhibitor coagulant complex is injected into a vein through an IV. (
  • For routine prevention of bleeding, anti-inhibitor coagulant complex may be given every other day. (
  • Anti-inhibitor coagulant complex is a powder medicine that must be mixed with a liquid (diluent) before using it. (
  • Reports from self-reported databases show there have been no confirmed reports of transmission of hepatitis A, B, or C, or human immunodeficiency virus (HIV) associated with the use of FEIBA [Anti-Inhibitor Coagulant Complex] since the introduction of vapor heat treatment. (
  • OBJECTIVES: To develop a sleep hypoxia (SH) in emphysema (SHE) rat model and to explore whether SHE results in more severe hepatic inflammation than emphysema alone and whether the inflammation changes levels of coagulant/anticoagulant factors synthesized in the liver. (
  • CATEGORY CLASS Anti coagulant PURPOSE OF MEDICATION Expected Pharmacological Action Therapeutic Use prevents conversion of fibrinogen and prot- prevents of DVT, DE, MI, open heart surgery hrombin to thrombin by enhancing inhibitory effects of antithrombin III (ATI, p. 191) A-FIB, anticoagulant in dialysis and transfusion procedures, treatment of DIC. (
  • Also, from a flocculation point of view tapioca starch does not necessarily need a coagulant whereas the effectiveness of potato starch increases with poly DADMAC. (
  • All blood coagulant medication wholesalers & blood coagulant medication manufacturers come from members. (
  • All coagulants used in water treatment wholesalers & coagulants used in water treatment manufacturers come from members. (
  • All coagulant aids in water treatment wholesalers & coagulant aids in water treatment manufacturers come from members. (
  • The vitamin helps activate these coagulant proteins by performing chemical modifications on amino acids within the protein, changing the proteins from inactive to their biologically active forms as needed. (
  • Enzymatic characterization of two plant coagulants: Cynara cardunculus L. and Ficus carica L. (
  • One of the most commonly used anti-coagulants is aspirin. (
  • These coagulants are commonly known as anionic trash collectors (ATC). (
  • The most commonly used coagulant aids are synthetic polyelectrolytes, although some soluble starch products are still in use. (
  • The market for blood coagulants is growing due to factors such as increasing awareness and prevalence of bleeding disorders, rise in accidents and surgeries, rise in chemotherapy, greater screening of patients with hemophilia and other blood disorders, excellent reimbursement for these class of medicines and their inclusion in essential medicines list etc. (
  • To my knowledge this is the first report on the presence of coagulant protein in Brassica seeds. (
  • Information regarding the coagulant effect of the seeds was first published in 1979. (
  • polymer coagulant was additionally used to enhance sedimentation velocity of the. (
  • At one concentration of coagulant, the zeta potential reaches zero. (
  • Then, with increasing coagulant concentration, the net charge on the particle becomes positive. (
  • The total infectious virus concentration in the suspension of floc particles that eventually formed by dosing with coagulant was measured after the floc particles were dissolved by raising the pH with an alkaline beef extract solution. (
  • For CA concentration at 12-18 wt% and CS concentration at up to 4 wt% in the spinning dope solutions, the blend hollow fibers were successfully prepared with outer surface pore sizes, specific surface areas and porosities in the range of 0.54-0.049 μm, 10.4-14.5 m2/g and 80.6-70.4%, respectively, depending on the CA and CS amounts in the spinning dope solutions and the coagulants used. (
  • Hart, which has already had success in the manufacture of blood coagulants for administration by GPs in community practices is increasingly moving into supplying products for the surgical management of bleeding patients. (
  • The Brazilian lancehead is one of several South American pit vipers that produce venom that has proven to be a powerful blood coagulant. (
  • It is important for parents who are planning to bank their baby's cord blood to ask the cord blood bank what type of anti-coagulant it uses in its cord blood collection bag. (
  • Because of heparin's drawbacks, CPD has been nearly unanimously chosen as the best anti-coagulant for cord blood banking. (
  • In addition, liquid CPD is the preferred anti-coagulant of Dr. Joanne Kurtzberg, a well-respected researcher at Duke University Medical Center, and Pablo Rubenstein, the founder and current director of the National Cord Blood Program, the first public cord blood bank. (
  • This invention relates to coagulants or clotting agents and more particularly relates to prepackaged bandages or absorbent pads saturated with a coagulant solution so as to be effective in clotting blood at the site of a wound in a reliable and efficient manner. (
  • We doesn't provide blood coagulant medication products or service, please contact them directly and verify their companies info carefully. (
  • The market for blood coagulants favors companies with strong research and development and hi tech in-house skills. (
  • Evaluation of analgesic, anti-inflammatory, anti-depressant and anti-coagulant properties of Lactuca sativa (CV. (
  • Gypsum, also called calcium sulfate, is the most widely used coagulant in making tofu. (
  • Calcium sulfate is the most traditional and widely used coagulant for tofu. (
  • Patients who have undergone major heart surgery, including valve replacement and heart bypass surgery will generally take these ant-coagulants to avoid the chance of a clot forming around the new valve or artery. (
  • Detecting the levels of coagulant molecular markers in patients with intracerebral hemorrhage greatly contributes to the early diagnosis of secondary cerebral infarction and improvement in prognosis, which is worthy being promoted in clinical practice. (
  • To discover the value of coagulant molecular marker in detecting the cerebral infarction after intracerebral hemorrhage, we enrolled 42 patients with cerebral infarction after intracerebral hemorrhage as the experiment group, 42 patient's only intracerebral hemorrhage as the hemorrhage control group, and 42 healthy people as the healthy control group. (