Coagulants: Agents that cause clotting.Factor VII: Heat- and storage-stable plasma protein that is activated by tissue thromboplastin to form factor VIIa in the extrinsic pathway of blood coagulation. The activated form then catalyzes the activation of factor X to factor Xa.Blood Coagulation: The process of the interaction of BLOOD COAGULATION FACTORS that results in an insoluble FIBRIN clot.Factor VIII: Blood-coagulation factor VIII. Antihemophilic factor that is part of the factor VIII/von Willebrand factor complex. Factor VIII is produced in the liver and acts in the intrinsic pathway of blood coagulation. It serves as a cofactor in factor X activation and this action is markedly enhanced by small amounts of thrombin.Kaolin: The most common mineral of a group of hydrated aluminum silicates, approximately H2Al2Si2O8-H2O. It is prepared for pharmaceutical and medicinal purposes by levigating with water to remove sand, etc. (From Merck Index, 11th ed) The name is derived from Kao-ling (Chinese: "high ridge"), the original site. (From Grant & Hackh's Chemical Dictionary, 5th ed)Blood Coagulation Tests: Laboratory tests for evaluating the individual's clotting mechanism.Factor X: Storage-stable glycoprotein blood coagulation factor that can be activated to factor Xa by both the intrinsic and extrinsic pathways. A deficiency of factor X, sometimes called Stuart-Prower factor deficiency, may lead to a systemic coagulation disorder.Factor IX: Storage-stable blood coagulation factor acting in the intrinsic pathway. Its activated form, IXa, forms a complex with factor VIII and calcium on platelet factor 3 to activate factor X to Xa. Deficiency of factor IX results in HEMOPHILIA B (Christmas Disease).Moringa oleifera: A plant species of the family Moringaceae, order Capparales, subclass Dilleniidae. It is a source of niaziminin and hypotensive thiocarbamate glycosides.Factor XI Deficiency: A hereditary deficiency of blood coagulation factor XI (also known as plasma thromboplastin antecedent or PTA or antihemophilic factor C) resulting in a systemic blood-clotting defect called hemophilia C or Rosenthal's syndrome, that may resemble classical hemophilia.Thromboplastin: Constituent composed of protein and phospholipid that is widely distributed in many tissues. It serves as a cofactor with factor VIIa to activate factor X in the extrinsic pathway of blood coagulation.Factor VII Deficiency: An autosomal recessive characteristic or a coagulation disorder acquired in association with VITAMIN K DEFICIENCY. FACTOR VII is a Vitamin K dependent glycoprotein essential to the extrinsic pathway of coagulation.Kininogens: Endogenous peptides present in most body fluids. Certain enzymes convert them to active KININS which are involved in inflammation, blood clotting, complement reactions, etc. Kininogens belong to the cystatin superfamily. They are cysteine proteinase inhibitors. HIGH-MOLECULAR-WEIGHT KININOGEN; (HMWK); is split by plasma kallikrein to produce BRADYKININ. LOW-MOLECULAR-WEIGHT KININOGEN; (LMWK); is split by tissue kallikrein to produce KALLIDIN.Blood Coagulation Factors: Endogenous substances, usually proteins, that are involved in the blood coagulation process.Factor XIa: Activated form of factor XI. In the intrinsic pathway, Factor XI is activated to XIa by factor XIIa in the presence of cofactor HMWK; (HIGH MOLECULAR WEIGHT KININOGEN). Factor XIa then activates factor IX to factor IXa in the presence of calcium.Tosylarginine Methyl Ester: Arginine derivative which is a substrate for many proteolytic enzymes. As a substrate for the esterase from the first component of complement, it inhibits the action of C(l) on C(4).Factor XI: Stable blood coagulation factor involved in the intrinsic pathway. The activated form XIa activates factor IX to IXa. Deficiency of factor XI is often called hemophilia C.Prothrombin Time: Clotting time of PLASMA recalcified in the presence of excess TISSUE THROMBOPLASTIN. Factors measured are FIBRINOGEN; PROTHROMBIN; FACTOR V; FACTOR VII; and FACTOR X. It is used for monitoring anticoagulant therapy with COUMARINS.Hemophilia A: The classic hemophilia resulting from a deficiency of factor VIII. It is an inherited disorder of blood coagulation characterized by a permanent tendency to hemorrhage.Prekallikrein: A plasma protein which is the precursor of kallikrein. Plasma that is deficient in prekallikrein has been found to be abnormal in thromboplastin formation, kinin generation, evolution of a permeability globulin, and plasmin formation. The absence of prekallikrein in plasma leads to Fletcher factor deficiency, a congenital disease.Electrocoagulation: Procedures using an electrically heated wire or scalpel to treat hemorrhage (e.g., bleeding ulcers) and to ablate tumors, mucosal lesions, and refractory arrhythmias. It is different from ELECTROSURGERY which is used more for cutting tissue than destroying and in which the patient is part of the electric circuit.Bothrops: A genus of poisonous snakes of the VIPERIDAE family. About 50 species are known and all are found in tropical America and southern South America. Bothrops atrox is the fer-de-lance and B. jararaca is the jararaca. (Goin, Goin, and Zug, Introduction to Herpetology, 3d ed, p336)Partial Thromboplastin Time: The time required for the appearance of FIBRIN strands following the mixing of PLASMA with phospholipid platelet substitute (e.g., crude cephalins, soybean phosphatides). It is a test of the intrinsic pathway (factors VIII, IX, XI, and XII) and the common pathway (fibrinogen, prothrombin, factors V and X) of BLOOD COAGULATION. It is used as a screening test and to monitor HEPARIN therapy.Factor VIIa: Activated form of factor VII. Factor VIIa activates factor X in the extrinsic pathway of blood coagulation.Dysprosium: Dysprosium. An element of the rare earth family that has the atomic symbol Dy, atomic number 66, and atomic weight 162.50. Dysprosium is a silvery metal used primarily in the form of various salts.Thrombin: An enzyme formed from PROTHROMBIN that converts FIBRINOGEN to FIBRIN.Factor XIIa: Activated form of factor XII. In the initial event in the intrinsic pathway of blood coagulation, kallikrein (with cofactor HIGH MOLECULAR WEIGHT KININOGEN) cleaves factor XII to XIIa. Factor XIIa is then further cleaved by kallikrein, plasmin, and trypsin to yield smaller factor XII fragments (Hageman-Factor fragments). These fragments increase the activity of prekallikrein to kallikrein but decrease the procoagulant activity of factor XII.Crotalid Venoms: Venoms from snakes of the subfamily Crotalinae or pit vipers, found mostly in the Americas. They include the rattlesnake, cottonmouth, fer-de-lance, bushmaster, and American copperhead. Their venoms contain nontoxic proteins, cardio-, hemo-, cyto-, and neurotoxins, and many enzymes, especially phospholipases A. Many of the toxins have been characterized.Neodymium: Neodymium. An element of the rare earth family of metals. It has the atomic symbol Nd, atomic number 60, and atomic weight 144.24, and is used in industrial applications.von Willebrand Diseases: Group of hemorrhagic disorders in which the VON WILLEBRAND FACTOR is either quantitatively or qualitatively abnormal. They are usually inherited as an autosomal dominant trait though rare kindreds are autosomal recessive. Symptoms vary depending on severity and disease type but may include prolonged bleeding time, deficiency of factor VIII, and impaired platelet adhesion.Fibrinogen: Plasma glycoprotein clotted by thrombin, composed of a dimer of three non-identical pairs of polypeptide chains (alpha, beta, gamma) held together by disulfide bonds. Fibrinogen clotting is a sol-gel change involving complex molecular arrangements: whereas fibrinogen is cleaved by thrombin to form polypeptides A and B, the proteolytic action of other enzymes yields different fibrinogen degradation products.Prothrombin: A plasma protein that is the inactive precursor of thrombin. It is converted to thrombin by a prothrombin activator complex consisting of factor Xa, factor V, phospholipid, and calcium ions. Deficiency of prothrombin leads to hypoprothrombinemia.Benzoylarginine Nitroanilide: A chromogenic substrate that permits direct measurement of peptide hydrolase activity, e.g., papain and trypsin, by colorimetry. The substrate liberates p-nitroaniline as a chromogenic product.Snakes: Limbless REPTILES of the suborder Serpentes.Factor XII: Stable blood coagulation factor activated by contact with the subendothelial surface of an injured vessel. Along with prekallikrein, it serves as the contact factor that initiates the intrinsic pathway of blood coagulation. Kallikrein activates factor XII to XIIa. Deficiency of factor XII, also called the Hageman trait, leads to increased incidence of thromboembolic disease. Mutations in the gene for factor XII that appear to increase factor XII amidolytic activity are associated with HEREDITARY ANGIOEDEMA TYPE III.Blood Coagulation Disorders: Hemorrhagic and thrombotic disorders that occur as a consequence of abnormalities in blood coagulation due to a variety of factors such as COAGULATION PROTEIN DISORDERS; BLOOD PLATELET DISORDERS; BLOOD PROTEIN DISORDERS or nutritional conditions.Antigens: Substances that are recognized by the immune system and induce an immune reaction.Argon Plasma Coagulation: A method of tissue ablation and bleeding control that uses ARGON plasma (ionized argon gas) to deliver a current of thermocoagulating energy to the area of tissue to be coagulated.von Willebrand Factor: A high-molecular-weight plasma protein, produced by endothelial cells and megakaryocytes, that is part of the factor VIII/von Willebrand factor complex. The von Willebrand factor has receptors for collagen, platelets, and ristocetin activity as well as the immunologically distinct antigenic determinants. It functions in adhesion of platelets to collagen and hemostatic plug formation. The prolonged bleeding time in VON WILLEBRAND DISEASES is due to the deficiency of this factor.Factor IXa: Activated form of factor IX. This activation can take place via the intrinsic pathway by the action of factor XIa and calcium, or via the extrinsic pathway by the action of factor VIIa, thromboplastin, and calcium. Factor IXa serves to activate factor X to Xa by cleaving the arginyl-leucine peptide bond in factor X.Antivenins: Antisera used to counteract poisoning by animal VENOMS, especially SNAKE VENOMS.Factor V: Heat- and storage-labile plasma glycoprotein which accelerates the conversion of prothrombin to thrombin in blood coagulation. Factor V accomplishes this by forming a complex with factor Xa, phospholipid, and calcium (prothrombinase complex). Deficiency of factor V leads to Owren's disease.Snake Venoms: Solutions or mixtures of toxic and nontoxic substances elaborated by snake (Ophidia) salivary glands for the purpose of killing prey or disabling predators and delivered by grooved or hollow fangs. They usually contain enzymes, toxins, and other factors.Leonurus: A plant genus of the family LAMIACEAE that contains leonurine.Factor Xa: Activated form of factor X that participates in both the intrinsic and extrinsic pathways of blood coagulation. It catalyzes the conversion of prothrombin to thrombin in conjunction with other cofactors.Hemostasis: The process which spontaneously arrests the flow of BLOOD from vessels carrying blood under pressure. It is accomplished by contraction of the vessels, adhesion and aggregation of formed blood elements (eg. ERYTHROCYTE AGGREGATION), and the process of BLOOD COAGULATION.Serum Globulins: All blood proteins except albumin ( = SERUM ALBUMIN, which is not a globulin) and FIBRINOGEN (which is not in the serum). The serum globulins are subdivided into ALPHA-GLOBULINS; BETA-GLOBULINS; and GAMMA-GLOBULINS on the basis of their electrophoretic mobilities. (From Dorland, 28th ed)Factor VIIIa: Activated form of factor VIII. The B-domain of factor VIII is proteolytically cleaved by thrombin to form factor VIIIa. Factor VIIIa exists as a non-covalent dimer in a metal-linked (probably calcium) complex and functions as a cofactor in the enzymatic activation of factor X by factor IXa. Factor VIIIa is similar in structure and generation to factor Va.Fibrinolysis: The natural enzymatic dissolution of FIBRIN.Thrombin Time: Clotting time of PLASMA mixed with a THROMBIN solution. It is a measure of the conversion of FIBRINOGEN to FIBRIN, which is prolonged by AFIBRINOGENEMIA, abnormal fibrinogen, or the presence of inhibitory substances, e.g., fibrin-fibrinogen degradation products, or HEPARIN. BATROXOBIN, a thrombin-like enzyme unaffected by the presence of heparin, may be used in place of thrombin.Antithrombin III: A plasma alpha 2 glycoprotein that accounts for the major antithrombin activity of normal plasma and also inhibits several other enzymes. It is a member of the serpin superfamily.Kallikreins: Proteolytic enzymes from the serine endopeptidase family found in normal blood and urine. Specifically, Kallikreins are potent vasodilators and hypotensives and increase vascular permeability and affect smooth muscle. They act as infertility agents in men. Three forms are recognized, PLASMA KALLIKREIN (EC 3.4.21.34), TISSUE KALLIKREIN (EC 3.4.21.35), and PROSTATE-SPECIFIC ANTIGEN (EC 3.4.21.77).Deamino Arginine Vasopressin: A synthetic analog of the pituitary hormone, ARGININE VASOPRESSIN. Its action is mediated by the VASOPRESSIN receptor V2. It has prolonged antidiuretic activity, but little pressor effects. It also modulates levels of circulating FACTOR VIII and VON WILLEBRAND FACTOR.Microwaves: That portion of the electromagnetic spectrum from the UHF (ultrahigh frequency) radio waves and extending into the INFRARED RAYS frequencies.Disseminated Intravascular Coagulation: A disorder characterized by procoagulant substances entering the general circulation causing a systemic thrombotic process. The activation of the clotting mechanism may arise from any of a number of disorders. A majority of the patients manifest skin lesions, sometimes leading to PURPURA FULMINANS.Venoms: Poisonous animal secretions forming fluid mixtures of many different enzymes, toxins, and other substances. These substances are produced in specialized glands and secreted through specialized delivery systems (nematocysts, spines, fangs, etc.) for disabling prey or predator.Protein C: A vitamin-K dependent zymogen present in the blood, which, upon activation by thrombin and thrombomodulin exerts anticoagulant properties by inactivating factors Va and VIIIa at the rate-limiting steps of thrombin formation.Viper Venoms: Venoms from SNAKES of the viperid family. They tend to be less toxic than elapid or hydrophid venoms and act mainly on the vascular system, interfering with coagulation and capillary membrane integrity and are highly cytotoxic. They contain large amounts of several enzymes, other factors, and some toxins.Isoflurophate: A di-isopropyl-fluorophosphate which is an irreversible cholinesterase inhibitor used to investigate the NERVOUS SYSTEM.Blood Platelets: Non-nucleated disk-shaped cells formed in the megakaryocyte and found in the blood of all mammals. They are mainly involved in blood coagulation.Hemophilia B: A deficiency of blood coagulation factor IX inherited as an X-linked disorder. (Also known as Christmas Disease, after the first patient studied in detail, not the holy day.) Historical and clinical features resemble those in classic hemophilia (HEMOPHILIA A), but patients present with fewer symptoms. Severity of bleeding is usually similar in members of a single family. Many patients are asymptomatic until the hemostatic system is stressed by surgery or trauma. Treatment is similar to that for hemophilia A. (From Cecil Textbook of Medicine, 19th ed, p1008)Molecular Weight: The sum of the weight of all the atoms in a molecule.Plasma: The residual portion of BLOOD that is left after removal of BLOOD CELLS by CENTRIFUGATION without prior BLOOD COAGULATION.EsterasesReceptor, PAR-1: A thrombin receptor subtype that couples to HETEROTRIMERIC GTP-BINDING PROTEINS resulting in the activation of a variety of signaling mechanisms including decreased intracellular CYCLIC AMP, increased TYPE C PHOSPHOLIPASES and increased PHOSPHOLIPASE A2.Electrophoresis, Polyacrylamide Gel: Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.Receptors, Thrombin: A family of proteinase-activated receptors that are specific for THROMBIN. They are found primarily on PLATELETS and on ENDOTHELIAL CELLS. Activation of thrombin receptors occurs through the proteolytic action of THROMBIN, which cleaves the N-terminal peptide from the receptor to reveal a new N-terminal peptide that is a cryptic ligand for the receptor. The receptors signal through HETEROTRIMERIC GTP-BINDING PROTEINS. Small synthetic peptides that contain the unmasked N-terminal peptide sequence can also activate the receptor in the absence of proteolytic activity.Anticoagulants: Agents that prevent clotting.Thrombosis: Formation and development of a thrombus or blood clot in the blood vessel.Cattle: Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.Fibrin: A protein derived from FIBRINOGEN in the presence of THROMBIN, which forms part of the blood clot.Chromatography, Ion Exchange: Separation technique in which the stationary phase consists of ion exchange resins. The resins contain loosely held small ions that easily exchange places with other small ions of like charge present in solutions washed over the resins.Chromatography, Gel: Chromatography on non-ionic gels without regard to the mechanism of solute discrimination.Endothelium: A layer of epithelium that lines the heart, blood vessels (ENDOTHELIUM, VASCULAR), lymph vessels (ENDOTHELIUM, LYMPHATIC), and the serous cavities of the body.Kinetics: The rate dynamics in chemical or physical systems.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Platelet Aggregation: The attachment of PLATELETS to one another. This clumping together can be induced by a number of agents (e.g., THROMBIN; COLLAGEN) and is part of the mechanism leading to the formation of a THROMBUS.Immunoglobulin Fab Fragments: Univalent antigen-binding fragments composed of one entire IMMUNOGLOBULIN LIGHT CHAIN and the amino terminal end of one of the IMMUNOGLOBULIN HEAVY CHAINS from the hinge region, linked to each other by disulfide bonds. Fab contains the IMMUNOGLOBULIN VARIABLE REGIONS, which are part of the antigen-binding site, and the first IMMUNOGLOBULIN CONSTANT REGIONS. This fragment can be obtained by digestion of immunoglobulins with the proteolytic enzyme PAPAIN.Postprandial Period: The time frame after a meal or FOOD INTAKE.Heparin: A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges. The molecular weight ranges from six to twenty thousand. Heparin occurs in and is obtained from liver, lung, mast cells, etc., of vertebrates. Its function is unknown, but it is used to prevent blood clotting in vivo and vitro, in the form of many different salts.Peptide Fragments: Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.Arginine: An essential amino acid that is physiologically active in the L-form.Phospholipids: Lipids containing one or more phosphate groups, particularly those derived from either glycerol (phosphoglycerides see GLYCEROPHOSPHOLIPIDS) or sphingosine (SPHINGOLIPIDS). They are polar lipids that are of great importance for the structure and function of cell membranes and are the most abundant of membrane lipids, although not stored in large amounts in the system.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Plasminogen Activator Inhibitor 1: A member of the serpin family of proteins. It inhibits both the tissue-type and urokinase-type plasminogen activators.Endothelium, Vascular: Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.Dietary Fats: Fats present in food, especially in animal products such as meat, meat products, butter, ghee. They are present in lower amounts in nuts, seeds, and avocados.TriglyceridesStructure-Activity Relationship: The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Enzyme Activation: Conversion of an inactive form of an enzyme to one possessing metabolic activity. It includes 1, activation by ions (activators); 2, activation by cofactors (coenzymes); and 3, conversion of an enzyme precursor (proenzyme or zymogen) to an active enzyme.Recombinant Proteins: Proteins prepared by recombinant DNA technology.Calcium: A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.Protein Binding: The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Binding Sites: The parts of a macromolecule that directly participate in its specific combination with another molecule.Rabbits: The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Polymorphism, Genetic: The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.

Leukocyte microparticles stimulate endothelial cell cytokine release and tissue factor induction in a JNK1 signaling pathway. (1/178)

A role of membrane microparticles (MP) released by vascular cells in endothelial cell (EC) activation was investigated. Flow cytofluorimetric analysis of blood samples from normal volunteers revealed the presence of an heterogeneous MP population, which increased by approximately 2-fold after inflammatory stimulation with the chemotactic peptide, N-formyl-Met-Leu-Phe (2,799 +/- 360 versus 5241 +/- 640, p < 0.001). Blood-derived MP stimulated release of EC cytokines interleukin (IL)-6 (377 +/- 68 pg/ml) and MCP-1 (1, 282 +/- 79) and up-regulated de novo expression of tissue factor on the EC surface. This was associated with generation of a factor Xa-dependent procoagulant response (2.28 +/- 0.56 nM factor Xa/min/10(4) cells), in a reaction inhibited by a monoclonal antibody to tissue factor. Fluorescent labeling with antibodies to platelet GPIbalpha or leukocyte lactoferrin demonstrated that circulating MP originated from both platelets and leukocytes. However, depletion of platelet MP with an antibody to GPIbalpha did not reduce EC IL-6 release, and, similarly, MP from thrombin-stimulated platelets did not induce IL-6 release from endothelium. EC stimulation with leukocyte MP did not result in activation of the transcription factor NF-kappaB and was not associated with tyrosine phosphorylation of extracellular signal-regulated protein kinase, ERK1. In contrast, leukocyte MP stimulated a sustained, time-dependent increased tyrosine phosphorylation of approximately 46-kDa c-Jun NH(2)-terminal kinase (JNK1) in EC. These findings demonstrate that circulating leukocyte MP are up-regulated by inflammatory stimulation in vivo and activate a stress signaling pathway in EC, leading to increased procoagulant and proinflammatory activity. This may provide an alternative mechanism of EC activation, potentially contributing to dysregulation of endothelial functions during vascular injury.  (+info)

Procoagulant effect of anti-beta2-glycoprotein I antibodies with lupus anticoagulant activity. (2/178)

Prothrombin time (PT) is routinely used to monitor oral anticoagulant treatment in patients with the antiphospholipid antibody syndrome (APS). The fact that PT is a phospholipid (PL)-dependent coagulation test raises the possibility that lupus anticoagulant (LA) might interfere with this test, thus complicating the control of anticoagulant treatment. The effect of 6 affinity-purified preparations of anti- (a)beta2-glycoprotein I (GPI) antibodies with LA activity on the PT was tested. Instead of prolonging PT as expected, the abeta2-GPI antibodies reduced the PT of both normal plasma and anticoagulated plasma by a mean of 2.4 seconds and 5.6 seconds, respectively. This effect was also observed using other 5 commercially available preparations of thromboplastin. The abeta2-GPI-mediated reduction in PT was dose-dependent and was lost upon removal of beta2-GPI. The failure of abeta2-GPI antibodies to express LA activity in PT was found to depend on the fact that calcium ions were added together with PL at the beginning of the assay. In fact, modification of the standard diluted Russell viper venom time (dRVVT) test by adding calcium ions together with PL resulted in a loss of abeta2-GPI anticoagulant activity. The procoagulant effect was not as evident in an assay that used stimulated monocytes as a source of thromboplastin. These results show that abeta2-GPI antibodies exhibit an 'in vitro' procoagulant effect in PT and an anticoagulant effect in dRVVT only when the interaction with their antigen and PL occurs in the absence of calcium ions.  (+info)

Platelet factor 4-induced neutrophil-endothelial cell interaction: involvement of mechanisms and functional consequences different from those elicited by interleukin-8. (3/178)

Platelet factor 4 (PF-4), a member of the CXC-subfamily of chemokines, is secreted in high amounts by activated platelets. In previous studies, we found that PF-4 specifically binds to human polymorphonuclear granulocytes (PMN), but requires tumor necrosis factor-alpha (TNF-alpha) as a costimulus for the induction of effector functions in suspended cells. In the present study, we have examined PF-4 in comparison with interleukin-8 (IL-8) for its ability to promote interaction of PMN with cultured endothelial cells (EC). We show here for the first time that PF-4 dose-dependently induces PMN to undergo extremely firm adhesion to EC as well as to exocytose secondary granule contents in the presence of these cells. Interestingly, costimulation by TNF-alpha was not required, indicating that EC could provide a corresponding signal(s). As evident from antibody blocking experiments, PF-4-induced adhesion involved PMN-expressed L-selectin as well as leukocyte function-associated molecule-1 (LFA-1), whereas IL-8 involved MAC-1. Because blocking antibodies to LFA-1 but not to L-selectin or MAC-1 abrogated PF-4-dependent marker exocytosis from PMN, the costimulatory signal provided by EC appears to be elicited through cell-cell contact via LFA-1. IL-8, inducing the upregulation of MAC-1, did not elicit marker exocytosis in contact with EC. Our results suggest a role for PF-4 in the promotion of PMN-EC interaction that is virtually different from that exhibited by other CXC-chemokines such as IL-8.  (+info)

Hydrophobic contact between the two epidermal growth factor-like domains of blood coagulation factor IX contributes to enzymatic activity. (4/178)

The three-dimensional structure of activated factor IX comprises multiple contacts between the two epidermal growth factor (EGF)-like domains. One of these is a salt bridge between Glu(78) and Arg(94), which is essential for binding of factor IXa to its cofactor factor VIII and for factor VIII-dependent factor X activation (Christophe, O. D., Lenting, P. J., Kolkman, J. A., Brownlee, G. G., and Mertens, K. (1998) J. Biol. Chem. 273, 222-227). We now addressed the putative hydrophobic contact at the interface between the EGF-like domains. Recombinant factor IX chimeras were constructed in which hydrophobic regions Phe(75)-Phe(77) and Lys(106)-Val(108) were replaced by the corresponding sites of factor X and factor VII. Activated factor IX/factor X chimeras were indistinguishable from normal factor IXa with respect to factor IXa enzymatic activity. In contrast, factor IXa(75-77)/factor VII displayed approximately 2-fold increased factor X activation in the presence of factor VIII, suggesting that residues 75-77 contribute to cofactor-dependent factor X activation. Activation of factor X by factor IX(106-108)/factor VII was strongly decreased, both in the absence and presence of factor VIII. Activity could be restored by simultaneous substitution of the hydrophobic sites in both EGF-like domains for factor VII residues. These data suggest that factor IXa enzymatic activity requires hydrophobic contact between the two EGF-like domains.  (+info)

Phosphatidylinositol 3,4,5-trisphosphate regulates Ca(2+) entry via btk in platelets and megakaryocytes without increasing phospholipase C activity. (5/178)

The role of phosphatidylinositol 3,4,5-trisphosphate (PI3,4,5P(3)) and Btk in signalling by the collagen receptor glycoprotein VI was investigated. PI3,4,5P(3) was increased in platelets from mice deficient in the SH2 domain-containing inositol 5-phosphatase (SHIP), in response to collagen related peptide (CRP). Tyrosine phosphorylation and activation of phospholipase Cgamma2 (PLCgamma2) were unaltered in SHIP(-/-) platelets, whereas Btk was heavily tyrosine phosphorylated under basal conditions and maximally phosphorylated by low concentrations of CRP. There was an increase in basal Ca(2+), maximal expression of P-selectin, and potentiation of Ca(2+) and aminophospholipid exposure to CRP in SHIP(-/-) platelets in the presence of Ca(2+) (1 mM). Microinjection of PI3,4, 5P(3) into megakaryocytes caused a 3-fold increase in Ca(2+) in response to CRP, which was absent in X-linked immunodeficiency (Xid) mice, which have a mutation in the PH domain of Btk. There was a corresponding partial reduction in the sustained level of intracellular Ca(2+) in response to CRP in Xid mice but no change in PLC activity. These results demonstrate a novel pathway of Ca(2+) entry that involves PI3,4,5P(3) and Btk, and which is independent of increased PLC activity.  (+info)

A plasma kallikrein-dependent plasminogen cascade required for adipocyte differentiation. (6/178)

Here we show that plasma kallikrein (PKal) mediates a plasminogen (Plg) cascade in adipocyte differentiation. Ecotin, an inhibitor of serine proteases, inhibits cell-shape change, adipocyte-specific gene expression, and lipid accumulation during adipogenesis in culture. Deficiency of Plg, but not of urokinase or tissue-type plasminogen activator, suppresses adipogenesis during differentiation of 3T3-L1 cells and mammary-gland involution. PKal, which is inhibited by ecotin, is required for adipose conversion, Plg activation and 3T3-L1 differentiation. Human plasma lacking PKal does not support differentiation of 3T3-L1 cells. PKal is therefore a physiological regulator that acts in the Plg cascade during adipogenesis. We propose that the Plg cascade fosters adipocyte differentiation by degradation of the fibronectin-rich preadipocyte stromal matrix.  (+info)

Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen. (7/178)

Platelet adhesion on and activation by components of the extracellular matrix are crucial to arrest post-traumatic bleeding, but can also harm tissue by occluding diseased vessels. Integrin alpha2beta1 is thought to be essential for platelet adhesion to subendothelial collagens, facilitating subsequent interactions with the activating platelet collagen receptor, glycoprotein VI (GPVI). Here we show that Cre/loxP-mediated loss of beta1 integrin on platelets has no significant effect on the bleeding time in mice. Aggregation of beta1-null platelets to native fibrillar collagen is delayed, but not reduced, whereas aggregation to enzymatically digested soluble collagen is abolished. Furthermore, beta1-null platelets adhere to fibrillar, but not soluble collagen under static as well as low (150 s(-1)) and high (1000 s(-1)) shear flow conditions, probably through binding of alphaIIbbeta3 to von Willebrand factor. On the other hand, we show that platelets lacking GPVI can not activate integrins and consequently fail to adhere to and aggregate on fibrillar as well as soluble collagen. These data show that GPVI plays the central role in platelet-collagen interactions by activating different adhesive receptors, including alpha2beta1 integrin, which strengthens adhesion without being essential.  (+info)

Femoral artery thrombosis after percutaneous thrombin injection of an external iliac artery pseudoaneurysm. (8/178)

Ultrasound-guided percutaneous thrombin injection has been developed as a less invasive and highly successful treatment of iatrogenic femoral pseudoaneurysms. Most of these lesions have been the result of catheterization procedures. This method has proved to be highly effective, and few complications have been reported. Specifically, native arterial thrombosis, although recognized as a severe complication, has been mentioned only briefly in the literature. We present a case of the successful management of native arterial thrombosis after attempted percutaneous thrombin injection of a chronic external iliac artery pseudoaneurysm. This case serves to illustrate the risk factors for this complication and the treatment options once it occurs. The success of this treatment with acute iatrogenic femoral pseudoaneurysms may not necessarily translate into similar success in other anatomic locations and clinical situations.  (+info)

Press Release issued Jan 22, 2018: Classified as organic coagulants and inorganic coagulants. The inorganic coagulants can be split into are iron based coagulants and aluminium based coagulants. Iron based coagulants are used in reducing the biological decomposition products at low pH. In the removal of arsenic from water, iron based coagulants are more effective than aluminium based coagulants because of their higher affinity towards arsenic. Iron based coagulants are used in sewage and waste water treatment, whereas the aluminium based coagulants are used in industrial waste water treatment. Some of the benefits of using iron based coagulants are they totally remove the suspended solids, enhance turbidity removal, better COD and BOD removal, enhanced colour removal and many more. The major problem with the usage of aluminium based coagulants is that they adversely affect the environment. This is one of the major reason for the shift of trend towards using iron based coagulants. Moreover, the iron
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TEGO® Coagulant 4720. Based on polyfunctional non-ionic ingredients. Coagulant that works by heat sensitation of natural and synthetic latex. ...
The TouchSoft Coagulator® monopolar probe is a unique endoscopic accessory used for contact coagulation or tissue ablation throughout the colon.
View Test Prep - IMG-1981.jpg from NURSING 143 at ECPI University, Charlotte. MEDICATION Heparin REVIEW MODULE CHAPTER. CATEGORY CLASS Anti coagulant PURPOSE OF MEDICATION Expected Pharmacological
|h3||strong|CHINFIELD COAGULANT|/strong||/h3| |p||strong|Antihemorrhagic|/strong||/p| |p||strong|Benefits:|/strong| COAGULANTE CHINFIELD covers the whole picture of hemorrhages whatever their etiology and location thanks to the two active components of
ULTRION Coagulants were developed to handle the wide seasonal variation of surface waters to produce a consistent, high quality, and economical water source into your processes. | Ecolab
On rFVIIIFc Day 0, all participants underwent pharmacokinetic (PK) analysis with 50 IU/kg rFVIIIFc to estimate their PK parameters and guide the appropriate dose or interval of dosing. A subset of participants (Sequential PK subgroup) also had PK analyses performed with a single dose of 50 IU/kg Advate (Advate Day 0) within 8 weeks prior to rFVIIIFc Day 0. A ,= 96 hour washout was performed before the PK dose of Advate or rFVIIIFc was administered. Repeat PK profiling with a single dose of 50 IU/kg rFVIIIFc was conducted at Week 14 or after 12 to 24 weeks of prophylaxis with rFVIIIFc.. After PK assessments, all participants started twice weekly treatment with 25 IU/kg of rFVIIIFc via intravenous (IV) injection on Day 1 and 50 IU/kg on Day 4, followed by individualized dose and interval modification within the range of 25 to 65 IU/kg every 3 to 5 days, as determined by rFVIIIFc PK analysis, to maintain a trough level of 1% to 3% (or higher, as clinically indicated) FVIII activity.. ...
PK subgroup: After a Washout Period of ≥72 hours, at the Baseline Visit (28±7 days prior to Day 1), participants receive a single IV injection of prestudy FVIII over 5 (±2) minutes at a dose of 50 IU/kg, rounded up to the nearest 250 IU increment, for a PK assessment. Following a second Washout Period of ≥72 hours, participants receive a single IV injection of rFVIIIFc over 5 (±2) minutes at a dose of 50 IU/kg for PK assessment. The first prophylactic dose of rFVIIIFc is administered at a starting dose of 25 IU/kg IV injection on Day 1 and 50 IU/kg on Day 4. Dose increases to a maximum of 80 IU/kg, and frequency of administration to a minimum interval of once every 2 days, are allowed as indicated.. Non-PK subgroup: On Day 1, a first prophylactic dose of rFVIIIFc of 25 IU/kg IV injection is given, followed by a dose of 50 IU/kg on Day 4. Dose increases to a maximum of 80 IU/kg, and frequency of administration to a minimum interval of once every 2 days, are allowed as indicated. ...
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Article Effectiveness of coagulants and coagulant aids for the removal of filter-clogging Synedra. The occurrence of Synedra spp. in the source water of the CheongJu water treatment plant (South Korea) decreased filter run times of rapid sand filters...
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TM 55-1930-209-14&P-1 Legend for Control Symbols Located on Inhibitor Pump and Coagulant Covers Figure 13-10. Coagulant and Inhibitor Pump Controls (Sheet 2 of 2) 13-19 ...
ULTRION Coagulants were developed to handle the wide seasonal variation of surface waters to produce a consistent, high quality, and economical water source into your processes. | Nalco Water
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Can lead to behavioral working final Cut Pro year after April 30. Span classsp_pss430 itemsspannbsp018332Find homes Lebanese satellite television station coagulants in treatment wastewater listings in Collierville.
In addition to being a key component of the retention and drainage program, other applications include dye fixation, pitch and stickies control, coated broke treatment and alkaline size promotion. | Nalco Water
Home cheesemaking can involve more than milk, starter culture, and coagulant. Additives can change the flavor, consistency, and texture of homemade cheese.
The development of Prothrombin Complex Concentrates (PCCs) has led to better outcomes in patients receiving emergency reversal of warfarin. However, most published data describes the use of PCCs in the setting of major bleeding or emergent major surgery, with little information on neuraxial blockade. We describe a case of rapid warfarin reversal using PCC and subsequent surgery under spinal anaesthesia in an 87-year-old lady, for whom general anaesthesia was deemed high risk. Her international normalised ratio (INR) on the morning of surgery was 1.8, precluding neuraxial blockade; however, it was felt that given, the need for imminent surgery, immediate reversal of the warfarin was indicated. We administered a single dose of 23 units/kg PCC and 5 mg vitamin K. Her INR 1 hour following PCC was 1.2, and spinal anesthetic was administered. The patient then underwent excision of melanoma deposits from her leg and groin dissection. There were no complications, the patient recovered
The management of bleeding patients on vitamin K antagonist (VKA) therapy is a common clinical challenge. Current American College of Chest Physician (ACCP) guidelines recommend the use of prothrombin complex concentrates (PCCs) for rapid reversal of VKA-induced coagulopathy.1. While efficacy and safety of PCC are well established for VKA reversal, a well-defined dosing strategy is still lacking.. Recently, we studied the effectiveness of a low fixed dose regimen of 1040 IU F IX PCC compared to variable dosing to counteract VKA associated emergency bleeding.2 This prospective study showed that low fixed PCC dose was non-inferior to variable dosing in terms of clinical outcome. In reaching the target INR, defined as INR less than 2, the fixed dose was non-inferior in patients with an initial INR below 7.5, but not in patients with a higher INR.. An important question from both a clinical and costing point of view is whether additional interventions were needed in the fixed dose cohort to reach ...
There is uncertainty regarding the effectiveness and occurrence of thromboembolic events in patients treated with prothrombin complex concentrates (PCCs) for the management of major bleeding events (MBEs) on rivaroxaban or apixaban. We investigated the effectiveness of PCCs given for the management of MBEs in patients on rivaroxaban or apixaban. Between 1 January 2014 and 1 October 2016, we prospectively included patients on rivaroxaban or apixaban treated with PCCs for the management of MBEs. The effectiveness of PCCs was assessed by using the International Society of Thrombosis and Hemostasis Scientific and Standardization Subcommittee criteria for the assessment of the effectiveness of major bleeding management. The safety outcomes were thromboembolic events and all-cause mortality within 30 days after treatment with PCCs. A total of 84 patients received PCCs for the reversal of rivaroxaban or apixaban due to a MBE. PCCs were given at a median (interquartile range) dose of 2000 IU (1500-2000 ...
This page includes the following topics and synonyms: Prothrombin Complex Concentrate, Prothrombin Drug Combination, PCC, Beriplex, Octaplex, Kcentra, Cofact.
Professional guide for Prothrombin Complex Concentrate (Human) [(Factors II, VII, IX, X), Protein C, and Protein S]. Includes: pharmacology, pharmacokinetics, contraindications, interactions, adverse reactions and more.
The Global Prothrombin Complex Concentrates Market is likely to gain traction due to the significant drop in demand for its counterpart fresh frozen plasma (FFP). PCC is available easily due to its lack of blood group specificity.
Oxidized cholesterol compounds or oxysterols are thought to be potent membrane-destabilizing agents. Anionic phospholipids, chiefly phosphatidylserine, have a procoagulant potential due to their ability to favour the membrane assembly of the characteristic clotting enzyme complexes including the tissue factor-dependent initiating complex. However, in resting cells, phosphatidylserine is sequestered in the inner leaflet of the plasma membrane. When THP-1 monocytic cells were cultured in the presence of 7β-hydroxycholesterol (7β-OH) or 25-hydroxycholesterol (25-OH), prothrombinase, which reflects anionic phospholipid exposure and tissue factor (TF) procoagulant activities, increased in a time- and dose-dependent manner. 7β-OH appeared 1.5- to 2-fold more potent than 25-OH. Interestingly, no effect of cholesterol itself could be detected on procoagulant activities. Nevertheless, no difference in TF activity could be detected between oxysterol-treated and control cells after disruption. TF ...
Results 45 patients were treated with PCC and included in the analysis. Mean patient age was 59.64 years, 42.2% were women and 57.77% men. The average dose was 1604 IU, the global survival after seven days was 73.33% and 35.55% had concomitant treatment with fibrinogen.. 11.11% of the patients had been treated with oral anticoagulants (OAT) prior to the emergency bleeding,. 48.89% had polytraumatic wounds,. 4.44% had thrombocytopenia secondary to hepatopathy,. 0% had haemophilia,. 75.55% had an active haemorrhage,. 68.89% underwent surgery, when the PCC was administered.. Quick time (s) (% // INR):. ...
TEGO® Coagulant 4910 is based on organomodified siloxane and may be used for heat sensitization of natural and synthetic latex ...
A liquid designed to function as an effective primary coagulant for the removal of sediment from surface waters, and from many types of industrial wastewaters. Excludes both decontamination agents and chemical agents. ...
... When 3-cyanovinylcarbazole nucleoside (CNVK) is incorporated into an oligonucleotide, very rapid photo cross-linking to the complementary strand can be induced at one wavelength and rapid reversal of the cross-
SNF is a manufacturer of various monomers used as intermediates in various industries.. Some of the these monomers sold under the brand name Flocryl are. Products ...
Dosing Chemicals like RO Antiscalent, Coagulants ( Lime, PAC, Ferrous Sulphate & Alum) & PH Correction Chemicals.. We Offer customised Dosing System by understanding the dosing requirements. It also can be upgraded to automate by PLC and SCADA.. ...
stepping in, left and right. right as wrong can be. in the ether coagulant spins into a frothed beard. a hopeful thought can pass
MESA is a new type of thin film bandage that has an integrated coagulant that stops bleeding fast and promotes rapid healing. Here is my experience with it.
Background-Patients experiencing major bleeding while taking vitamin K antagonists (VKAs) require rapid VKA reversal. We performed a prospective clinical trial to compare non-activated four-factor prothrombin complex concentrate (4F-PCC) with plasma for urgent VKA reversal. Methods and Results-In this phase IIIb, multicenter, open-label, non-inferiority trial, non-surgical patients were randomized to 4F-PCC (containing coagulation factors II, VII, IX, X, and proteins C, S) or plasma. Primary analyses examined whether 4F-PCC was non-inferior to plasma for the co-primary endpoints of 24-hour hemostatic efficacy from start of infusion and INR correction (≤1.3) at 0.5 hours after end of infusion. The intent-to-treat-efficacy population comprised 202 patients (4F-PCC n=98; plasma n=104). Median (range) baseline INR was 3.90 (1.8-20.0) for the 4F-PCC group and 3.60 (1.9-38.9) for the plasma group. Effective hemostasis was achieved in 72.4% of patients receiving 4F-PCC versus 65.4% receiving plasma, ...
The report provides detailedinformation with respect to competitive landscape along with the top competitors in the Flocculant and Coagulant market.Furthermore, to help the clients make strategic decision, the reporthighlights a comprehensiveprofiling of leading players, their detailed analysis, their key developments along withthe market positioning. The report also foregrounds current and future market trends in order to justify the forthcoming attractive markets within the Flocculant and Coagulant market.Moreover, clients are also provided with segment-wise, region-wise, and country-wise analysis of the Flocculant and Coagulant market.To convey a proper analysis of all the data, the report comprises a number of figures, graphs, tables, and diagrams, which will help the clients get a crystal clear idea of the current trends in the Flocculant and Coagulant market. Additionally, the report also strategically analyzes the Flocculant and Coagulant market with regards to individual growth trends, ...
In the present study, several pre-polymerized coagulants of iron and aluminum were tested for their efficiency towards As(V) and As(III) removal from water sources. The results showed that the pre-polymerized coagulants of iron, such as poly-ferric sulfate and poly-ferric silicate chloride, were very efficient for As(V) removal. With regard to As(III) removal, among all examined coagulants, including the conventional ferric chloride, only the poly-ferric sulfate (PFS) was able to reduce As(III) to concentrations below the drinking water regulation limit of 10 μg/L. In contrast, all tested composite coagulants based on aluminum were not capable of removing efficiently both species of arsenic. PFS addition in water containing 4 mM of alkalinity and 25 μg/L of As(V) and As(III) (i.e., total arsenic concentration 50 μg/L) resulted in finished water with less than 5 μg/L arsenic, only by dosing 5 mg Fe-PFS/L at pH 7, whereas, simultaneously, the residual iron concentration was found well below its
BACKGROUND: This paper presents an analysis of 25 patient cases in which recombinant factor VIIa was used in the management of postpartum hemorrhage, including severe and/or life-threatening bleeds. Anecdotal experiences in the empirical use of this
Sales, means the sales volume of Human Prothrombin Complex Revenue, means the sales value of Human Prothrombin Complex This report studies sales (consumption) of Human Prothrombin Complex in United States market, focuses on the top players, with sales, price, revenue and market share for each player, covering Baxter CSL Bayer Grifols Octapharma Shanghai RAAS Hualan Bio
Our recent studies identified PARP activation as a novel pathway of diabetic vasculopathy.2 In vitro and in vivo endothelial cell dysfunction in response to high-glucose concentration was found to be associated with increased poly(ADP-ribos)ylation.2 Furthermore, the deterioration of endothelial function was prevented in endothelial cells and in vascular rings of animals in which PARP was genetically inactivated or PARP was pharmacologically inhibited.2. Two main pathways were proposed to explain the role of PARP in diabetic vascular alterations. The first pathway, the proinflammatory mediator production pathway, is related to data implicating a role for PARP in modulating the activation of nuclear factor-κB (NF-κB) and, subsequently, proinflammatory gene expression.6-8 The genes, activation of which are suppressed in the absence of PARP, include the gene for intercellular adhesion molecule-1 (ICAM-1)9 and the gene for iNOS.7,8 Adhesion molecules such as ICAM-1, iNOS expression, and NF-κB ...
[106 Pages Report] Check for Discount on Global Prothrombin Complex Market 2020 by Manufacturers, Regions, Type and Application, Forecast to 2025 report by Global Info Research. Market Overview The global Prothrombin Complex market size is expected...
ROCKVILLE, Md. -- The FDA has approved a genetically engineered version of the clotting protein factor VIII to prevent joint damage in children with hemophilia A.
Assalamualaikum dan salam sejahtera semua.Maaflah kerana dah lebih sebulan blog ini bersawang.Tuan punya blog tak sempat nak update apa apa, kerana kesibukan yang berpanjangan. Ni pun stop keja jap...dah bosan..lagipun nak tunggu member yang entah ke mana untuk menyambung kan keje yang belum siap. Sepanjang beberapa bulan ini banyak juga koleksi terbaru yang masuk dalam koleksi peribadi tuan punya blog,cuma masih takde masa untuk memasukkan entry kat blog ini. kalau ada kelapangan,insyaallah banyak entry menarik yang akan di paparkan. Entry kali ini,agak biasa jer. Cuma sekeping Coagulant Unit Federated Malay State. kupon ini digunakan pada masa dahulu untuk membeli cuka getah. Tarikh lakunya bergantung pada bulan tertentu. Yang nie bulan November. Kalau nak kumpul setiap bulan,jenuh la jugak..agak sukar nak jumpa bulan yang berbeza..tapi kalau leh jumpa tu,memang rezeki la ...
Calcium sulfate (gypsum): The traditional and most widely used coagulant to produce Chinese-style tofu. It produces a tofu that is tender but slightly brittle in texture. The coagulant itself has no perceivable taste. Use of this coagulant also makes a tofu that is rich in calcium. As such, many tofu manufacturers choose to use this coagulant to be able to market their tofu as a good source of dietary ...
PAC DDY Powder CoagulantGENERAL DESCRIPTIONPAC DDY is a powder with high grade quality coagulant for potable water treatment and wastewater treatment. PAC P185927
Human tissue factor is functionally expressed in hTF-KI transgenic mice, and effectively and specifically inhibited by the anti-hTF mAb, CNTO859.Pro-coagulant a
3 Answers (question resolved) - Posted in: buprenorphine, surgery - Answer: Out is for pain. Its not goingto make you bleed. If you have it in your ...
... refers to the tendency of a material in contact with the blood to produce a thrombus, or clot. It not only refers to fixed
http://biomedicine.gu.se/biomedicine/about-us/staff/department-of-medical-biochemistry-and-cell-biology/?publicationPageNumber=8&selectedTab=2&feedbackForm=true&returnAddress=http%3A%2F%2Fbiomedicine.gu.se%2Fbiomedicine%2Fabout-us%2Fstaff%2Fdepartment-of-medical-biochemistry-and-cell-biology%2F%3FpublicationPageNumber%3D9%26selectedTab%3D2%26languageId%3D100001%26userId%3Dxkanic&recipientName=Chatrine+Butler&encodedEmail=Y2hhdHJpbmUuYnV0bGVyQGd1LnNl&languageId=100001&userId=xkanic ...
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ZeoVit Iodide Complex Concentrate, 50 ml. - At AquaCave, we offer Best Prices, 5% Back, and Free Shipping on ZeoVit Iodide Complex Concentrate, 50 ml.. - Buy ZeoVit Iodide Complex Concentrate, 50 ml. - Now Only $49.99 - ZeoVit Iodide Complex Concentrate, 50 ml.For an improved coloration corals need iodide in different forms as well as additional elements enabeling an optimal assimilation of the iodide. Contains organic and inorganic iodide as well as bromine, potassium and fluorine. Recommended in any tank system.Dosing: 1 drop per 100 L/25 gallons per day.- See more at: http://www.aquariumspecialty.com/zeovit-iodide-complex-concentrate-50ml#sthash.IWFZUPLE.dpufFor an improved coloration corals need iodide in different forms as well as additional elements enabeling an optimal assimilation of the iodide. Contains organic and inorganic iodide as well as bromine, potassium and fluorine. Recommended in any tank system.Dosing: 1 drop per 100 L/25 gallons per day.Enhances blue colors, especially in certain
Table 1: The aluminum coagulants. Table 2. The main deposits of bauxite in Russia. Table 3. Characteristics of bauxite deposits owned by JSC Kazakhstan Aluminum. Table 4. Bauxite mining in the CIS in 2002-2014, kt.. Table 5. Production of bauxite by Russian enterprises in 2002-2014, kt.. Table 6. The main deposits of nepheline ores in Russia. Table 7: Composition of nepheline concentrate,%. Table 8: Production of nepheline ore (1) and the production of nepheline concentrate (2) in Russia in 2000-2014, mln t. Table 9. Production of alumina in Russia by enterprises in 2002-2014, kt.. Table 10. Production of sulfuric acid enterprises of Kazakhstan in 2007-2014, kt.. Table 11: Production of sulfuric acid by Russian enterprises in 2004-2014, kt.. Table 12: Production of hydrochloric acid by Russian enterprises in 2004-2014, kt.. Table 13: Volumes and directions of railway supplies of raw materials for the production of coagulants in 2002-2014, t. Table 14: Specifications Purified technical aluminum ...
... products effect consists in initiating and accelerating the haemocoagulation cascade.. BLOODCARE it has a significant role in starting haemocoagulation process. While applied, Factor VII is activated as well as the trombocyte activation is initiated by tissue factor. Due to anionactive characteristics of oxidised cellulose, BLOODCARE is able to form complex polymers with compounds such as fibrinogen or haemoglobin, therefore fibrinogen polymerisation is speeded up.. Calcium ions (powder and spray form) are used during protein complex fixation on cell membranes, in particular thrombocytes and endotel cells. Higher Ca2+ ion concentration stabilises activated Factor V and speeds up Factor XIII activity resulting in fibrinogen network stabilisation which is therefore able to create sufficiently organised structure for fibroblast growth and cicatrix formation. During coagulation process Ca2+ ions partially participate in thrombocyte adhesion to collagens of exposed wound, and also show ...
Despite many animal studies and clinical trials, mortality in sepsis remains high. This may be due to the fact that most experimental studies of sepsis employ young animals, whereas the majority of septic patients are elderly (60 − 70 years). The objective of the present study was to examine the sepsis-induced inflammatory and pro-coagulant responses in aged mice. Since running exercise protects against a variety of diseases, we also examined the effect of voluntary running on septic responses in aged mice. Male C57BL/6 mice were housed in our institute from 2-3 to 22 months (an age mimicking that of the elderly). Mice were prevented from becoming obese by food restriction (given 70-90% of ad libitum consumption amount). Between 20 and 22 months, a subgroup of mice ran voluntarily on wheels, alternating 1-3 days of running with 1-2 days of rest. At 22 months, mice were intraperitoneally injected with sterile saline (control) or 3.75 g/kg fecal slurry (septic). At 7 h post injection, we examined (1)
MEDLINE, EMBASE/Excerpta Medica, LILACS, Cochrane Injuries Group Specialized Register, Cochrane Central Register of Controlled Trials, National Research Register, NBS Systematic Review Initiative RCT Database, Meta-database of Ongoing Trials, KoreaMed, IndMed, PakMediNet, Cambridge Scientific abstracts, ZETOC, ISI Proceedings (all to March 2006); bibliographies of relevant studies; and experts ...
When warfarin reversal must be accomplished rapidly, such as in cases of active bleeding or in preparation for an invasive procedure, multiple options exist, chief among them being fresh frozen plasma (FFP) and four factor prothrombin complex concentrate (4-PCC). Between those two options, the ACCP guidelines suggest (soft recommendation) 4-PCC over FFP. This was based on low level data (very small studies) showing more rapid INR reversal using the former. This study, which came out after publication of the ACCP guidelines, added further weight in favor of 4-PCC in patients deemed appropriate for rapid warfarin reversal in the emergency setting. Though considered low level in that it was a retrospective study, it was larger (around 150 patients in both groups) than prior studies. Despite mounting evidence in favor of 4-PCC some experts (e.g. the authors of this review) remain skeptical as to whether 4-PCC is superior, awaiting information from randomized controlled trials. One such trial has ...
Biosensors can offer unparalleled insights into the temporal and spatial features of signaling in live cells. The AKAR2 biosensor enables the detection in real time of PKA-catalyzed phosphorylation events in live cells [15,42,43]. We successfully engineered AKAR2 to the N-terminus of AKAP5, providing a biosensor that reports from the local environment, in cis orientation with respect to AKAP5. The FRET-based signal generated from the AKAP5 biosensor displayed a rapid activation in response to beta-adrenergic stimulation. Within less than 10 s the FRET signal, reflecting in situ PKA-catalyzed phosphorylation of AKAP5, reached peak amplitude. PKA-catalyzed phosphorylation of AKAP5 underwent rapid reversal. PCDs confine AKAP5 to the cell membrane, in close proximity to the membrane-embedded adenylylcyclase that generates cyclic AMP. The localization of AKAP5 was highly uniform, decorating the inner leaflet of the cell membrane. AKAP12, in contrast, is sequestered in close proximity to the cell ...
Lafantaisie-Favreau, C.-H., Guzmán-Morales, J., Sun, J., Chen, G., Harris, A., Smith, T. D., ... Hoemann, C. D. (2013). Subchondral pre-solidified chitosan/blood implants elicit reproducible early osteochondral wound-repair responses including neutrophil and stromal cell chemotaxis, bone resorption and repair, enhanced repair tissue integration and delayed matrix deposition. BMC Musculoskeletal Disorders, 14. ...
Haemostasis plays a large and important role in otorhinolaryngology and head and neck surgery. It requires different techniques used on different areas of the head and neck. Whatever technique required, most procedures would be unable to be completed without adequate haemostasis. Certainly, postoperative complications would be high in the absence of effective haemostasis. New advancements in techniques and technology are enabling new ways to achieve haemostasis, adding to the surgical options available.. Was this article helpful?. ...
A number of proteins and genes affect the thickness of your blood to help maintain your health. Too-fast or too-slow blood coagulation can prove harmful,...
The cosmetic division is a recent development of SNF. We can now offer the cosmetics industry a range of specially designed polymers under the brand name of FloCare. Using the latest polymerization techniques developed in-house, FloCare polymers are easy to handle, quick to implement and can develop innovating formulas.. Specific performance tests have been put in place for the FloCare range in order for SNF to guarantee the constant quality of its polymers in regards to the application.. Products ...
Warfarin is a vitamin K antagonist, metabolized through the liver and can be reversed with vitamin K, prothrombin complex concentrates and frozen plasma.. LWMH inhibits factors Xa and IIa via accelerating the activity of ATIII. It is renally cleared and must be used with caution in patients with renal failure. Reversal can be obtained with protamine.. Rivaroxaban is an oral FXa inhibitor that is renally cleared and does not require coagulation monitoring. In cases of bleeding factor Xa levels can be used to monitor therapeutic levels. There are no approved antidotes for reversal and protocols for reversal are center dependent.. Dabigatran is an oral thrombin inhibitor that does not require coagulation monitoring. There is no reversible antidote and coagulation testing is typically not used to monitor PT/ PTT values. There are no antidotes for reversal but dialysis has been used with limited success.. Dentali F et al. Safety of prothrombin complex concentrates for rapid anticoagulation reversal ...
Natural coagulants are coagulants derived from plants and other locally available materials from the surrounding nature. Typical natural coagulants are prickly pear cactus, moringa seeds, broad beans and fava beans, which can be used for enhanced sedimentation as a pre-treatment step of drinking water.
Acquired haemophilia A (AHA) is a rare, serious bleeding disorder most often encountered in elderly patients. The mainstay of haemostatic management is with bypassing agents (BPAs) including recombinant activated factor VII (rFVIIa) and activated prothrombin complex concentrates (aPCCs). Their major limitation is incomplete efficacy, potential risk for thrombosis and the lack of routine laboratory assays for monitoring treatment response. Plasma-derived porcine FVIII (pd-pFVIII, Hyate C(®)), first used in the 1950s for the management of congenital haemophilia, has sufficient sequence homology to be haemostatic in humans, but the lack of complete homology facilitates efficacy even in the presence of human allo- and autoantibodies against human FVIII (hFVIII ...
Ongoing patent expirations and failed life cycle management efforts leave the established companies vulnerable regarding the future growth perspective of their recombinant coagulation factor business, but at the same time opens the door to potential new market entrants.. The recombinant factor VIII pipeline consists of more than ten novel molecules, four of them already in clinical stages, some are wild-type constructs, but many are longer acting variants of factor VIII. The recombinant factor IX pipeline even counts 15 developments with three in clinical phases. In the recombinant factor VIIa pipeline, all projects except one are modified versions, either short-acting or longer acting with four projects in the clinic and two more shortly to follow.. All of the next generation molecules need systemic intravenous administration, attempts to allow subcutaneous or even non-injectable administration regimes so far have not succeeded and leave space for future optimization.. SWOT analysis revealed ...
... ,The Wet-Field Coagulator provides precise episcleral, intrascleral, and intraocular hemostasis with reduced peripheral tissue trauma. Controlled Rf diathermy delivers targeted coagulation with the most comprehensive line of bipolar Eraser instruments, forceps and cables. This instrument combines en,medicine,medical supply,medical supplies,medical product
Individuals with chronically elevated glucose, most patients with type-2 diabetes, have increased inflammation (hs-CRP levels) and accelerated atherosclerosis, associated with acute vascular events. Up to date, it is not known whether hs-CRP or elevated glucose alter the expression and pre-mRNA splicing of tissue factor (TF), the primary initiator of blood coagulation. We have tested the hypothesis that hs-CRP and hyperglycemia singly or combined may increase tissue factor isoform expression. First, we determined changes in tissue factor isoform expression in whole blood and procoagulant activity (PCA) in human monocytic cells obtained from healthy volunteers (controls, n=20) and insulin-treated patients with type-2 diabetes (n=60). TF m-RNA was quantified for the full-length and soluble isoform by real-time PCR. To assess the impact of hs-CRP on TF, the patients were divided into two groups according to their hs-CRP (hs-CRP,0.3 mg/dl or ,0.3 mg/dl). Secondarily, PMN cells were isolated and ...
Its interesting that you can take something so deadly and turn it into something that has the potential to save lives," said Rice chemist Jeffrey Hartgerink.. Batroxobin is a haemotoxin that has similar properties to thrombin, a naturally occurring enzyme in humans that plays an important role in clotting. First recognised in 1936 for its coagulant capabilities, batroxobin is particularly useful for treating patients who have taken the anti-coagulant drug heparin.. "Theres a lot of different things that can trigger blood coagulation, but when youre on heparin, most of them dont work, or they work slowly or poorly," Hartgerink said in a statement.. "This is important because surgical bleeding in patients taking heparin can be a serious problem. The use of batroxobin allows us to get around this problem because it can immediately start the clotting process, regardless of whether heparin is there or not.". ...
Jerrold Levy, MD, of Duke University, discusses some of the late breaking clinical trial data and take-home points from ISTH 2015. The topics of greatest concern to clinicians in practice include: 1) There are evolving strategies for managing bleeding in patients taking direct oral anticoagulants, including the use of prothrombin complex concentrates, 2) the specific reversal strategies for Xa inhibitors and dabigatran are also evolving, 3) the approach to managing peri-procedural anticoagulation is changing due to the introduction of targeted NOAC reversal agents. , TV Network
The Report PharmaPoint: Hemophilia A and B Recombinant Factor Replacement Therapy - Global Drug Forecast and Market Analysis to 2024 provides information on pricing, market analysis, shares, forecast, and company profiles for key industry participants. - MarketResearchReports. ...
Government Bid Opportunity: Argon Plasma Coagulator System. Access many more 65 - Medical, Dental, and Veterinary Equipment Bids | Get your Free Government Bids Alert!
Anion Coagulant And Flocculant For Drilling Mud SuppliersAlibaba offers 9 Anion Coagulant And Flocculant For Drilling Mud Suppliers, and Anion Coagulant And Flocculant For Drilling Mud Manufacturers, Distributors, Factor...
The talk will present results on the discovery of a heparan sulfate hexasaccharide from a library of 46,656 natural sequences that selectively binds and activates heparin cofactor II (HCII), a plasma serpin, for accelerated inhibition of thrombin, a pro-coagulant protease ...
In this work, for high performance and wide range of ultrafiltration applications, the effects of the most widely used values of internal coagulant flow rates (ICFR) (i.e., 2.6, 3.6, 4, 5, 7, 9, 11, a
To the best of our knowledge, this is the first study investigating TG-related parameters following PCC administration in acute trauma patients. PCC therapy resulted in significantly higher ETP than in patients who received fibrinogen concentrate only or no coagulation therapy at all and, importantly, this was sustained over the first 3 to 4 days following PCC administration. AT was significantly lower in the FC-PCC group from ER admission until 3 to 4 days later, reaching a nadir on day 2. Hemostasis relies on a delicate balance between pro- and anticoagulant factors, and between thrombin potential and thrombin inhibition potential. This balance may have been impaired in the FC-PCC group, during a period when fibrinogen levels were increased above the normal range; similar findings have been reported in previous studies [34, 35]. The overall picture is increased thrombin potential (day 1 to day 4), increased substrate for coagulation (that is, fibrinogen reaching a plateau on day 4) and ...
For people with high responding inhibitors, utilizing factor is, in many cases, not possible because the inhibitor neutralizes even the largest possible dose of factor. In these cases treatment is based on the type of hemophilia and the nature of the bleed.. During a life or limb-threatening bleeding episode, physicians can remove antibodies from the body using a process called plasmapheresis, which lowers the level of antibodies to allow treatment with factor concentrate to treat the bleed. However, this is a temporary solution and within a few days the body will produce large amounts of new antibodies. For the person with a high responding inhibitor, most bleeding episodes are treated using bypassing products that include prothrombin complex concentrates (PCCs), activated prothrombin complex concentrates (APCCs) (i.e. Feiba VH, produced by Baxter). These bypassing products contain other factors that can stimulate the formation of a clot and stop bleeding. While these treatments are effective, ...
For people with high responding inhibitors, utilizing factor is, in many cases, not possible because the inhibitor neutralizes even the largest possible dose of factor. In these cases treatment is based on the type of hemophilia and the nature of the bleed.. During a life or limb-threatening bleeding episode, physicians can remove antibodies from the body using a process called plasmapheresis, which lowers the level of antibodies to allow treatment with factor concentrate to treat the bleed. However, this is a temporary solution and within a few days the body will produce large amounts of new antibodies. For the person with a high responding inhibitor, most bleeding episodes are treated using bypassing products that include prothrombin complex concentrates (PCCs), activated prothrombin complex concentrates (APCCs) (i.e. Feiba VH, produced by Baxter). These bypassing products contain other factors that can stimulate the formation of a clot and stop bleeding. While these treatments are effective, ...
Abstract: The feasibility of using a combination of Effective Microorganisms™(EM) and conventional chemical conditioner was evaluated in this study to assess and discern the dewatering properties of the secondary sludge which was produced from wastewater treatment plant of the medical assebly in Mosul City. Conventional coagulants such as lime, alum and ferrous sulfate, or six doses for each coagulant type i.e., 5-30, 10-60 and 25-150 mg L -1, respectively, were used in the sludge conditioning processes for the enhancement of the sludge dewatering capacity. The characteristics of the conditioned sludge at each dose, such as Specific Resistance to Filtration (SRF), were determined. Experimental results indicated that EM seeds had a passive effect on SRF value which was about 71.4 and 75% in lime and ferrous sulfate respectively. While in the alum conditioning process, a significant effect on SRF reduction was accomplished which was about -47.9 and -32.8% for EM and alum dose increments, ...
On April 16, 2015, Baxter International Inc. of Deerfield, Illinois, Baxter Healthcare Corp. of Deerfield, Illinois, and Baxter Healthcare SA of…
Largest Internet Trauma Care Site - Covers all aspects of injury prevention, evaluation and management. Includes an email Discussion group, Conference listings, Trauma Imagebank, Fellowship database. Home of Trauma Moulage on the Internet.
Langhammer, B., Sunnerhagen, K. S., Stanghelle, J. K., Sällström, S., Becker, F., & Fugl-Meyer, K. (2017). Life satisfaction in persons with severe stroke-A longitudinal report from the Sunnaas International Network (SIN) stroke study. European Stroke Journal, 2396987317695140.. Lindström, L., Skjærven, R., Bergman, E., Lundgren, M., Klungsøyr, K., Cnattingius, S., & Wikström, A. K. (2017). Chronic Hypertension in Women after Perinatal Exposure to Preeclampsia, Being Born Small for Gestational Age or Preterm. Paediatric and Perinatal Epidemiology.. Schultz, N. H., Tran, H. T. T., Bjørnsen, S., Henriksson, C. E., Sandset, P. M., & Holme, P. A. (2017). The reversal effect of prothrombin complex concentrate (PCC), activated PCC and recombinant activated factor VII against anticoagulation of Xa inhibitor. Thrombosis Journal, 15(1), 6.. Sulo, E., Nygård, O., Vollset, S. E., Igland, J., Ebbing, M., Østbye, T., Jørgensen, T., Sulo, G., & Tell, G. S. (2017). Time Trends and Educational ...
Paleomagnetism is the study of magnetization locked into rocks at the time of their formation. Paleomagnetic data show that while the geologic strata were being laid down, the earths magnetic field reversed its direction hundreds of times. Reversals are a very severe departure from steady decay of intensity. Both archaeomagnetic and paleomagnetic data contradict the early creationist assumption of constant decay of intensity. In 1988 I published a review paper documenting the great diversity and reliability of the data.[8]. A Creationist Theory for Reversals and Fluctuations The validity of the data required a new theory to explain them. In 1986 I suggested that strong flows of the fluid in the earths core could produce rapid reversals of the field during and after the Genesis flood.[9] The resulting disturbances in the core would cause the field intensity at the earths surface to fluctuate up and down for thousands of years afterwards.. This dynamic-decay theory is a more general version ...
Thank you for your interest in spreading the word on Arteriosclerosis, Thrombosis, and Vascular Biology.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. ...
Make sure your doctor knows if you have had a stroke, heart attack, deep vein thrombosis (DVT), or any other heart or blood clot problem in the last 3 months. This medicine may increase your risk of blood clots. Tell your doctor right away if you have a sudden or severe headache, problems with vision or speech, chest pain, trouble breathing or swallowing, swelling or tenderness in your leg, or numbness or weakness ...
An aqueous organic or inorganic suspension can be coagulated and then flocculated by flowing it past a shaped body comprising a mixture of water soluble multivalent metal coagulant and a water soluble organic polymeric flocculant in the form of substantially discrete particles. The surface of the shaped body is eroded by the flowing stream to form a solution of the coagulant in which the polymeric flocculant particles are entrained, and these subsequently dissolve into the suspension.
Determination of optimum coagulant and coagulant aid doses for treatment of drinking water and wastewater sources by sedimentation or dissolved air flotation-filtration (DAFF) for removal of turbidity, colour, dissolved organic carbon (DOC) or algal cells and to determine idealised floc structure and improved filtration performance ...
Worldwide commercial aircraft maintenance market is anticipated to showcase considerable expansion during the forecast period (from 2017 to 2022). Commercial aircraft m...
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Coagulation Testing Is The Basis For The Diagnosis Of Bleeding And Thrombotic Disorders As Well As The Mainstay Of Anti Coagulant Monitoring And Management The
Hello, are you looking for article NursingCrib.com Nursing Care Plan Hemophilia by nursingcrib? If it is true we are very fortunate in being able to provide information NursingCrib.com Nursing Care Plan Hemophilia by nursingcrib And good article NursingCrib.com Nursing Care Plan Hemophilia by nursingcrib This could benefit/solution for you. ...
If a woman is a carrier for hemophilia and has a child with a man who does not have hemophilia, what percentage of their sons would be expected to have hemophilia? What percentage of their daughters would be expected to be.
By the end of the summer, we were up to six hundred pounds a week. Then things dropped off quickly once September hit. I worked hard at marketing through the fall and picked up a few biggish clients at fifty pounds a week and Ive been making eight batches-320 pounds-twice a week pretty steadily since New Years. But the business keep growing. Ive begun some nine batch days to keep up with the demand, but physically, I am near my limits of production. It is such physically demanding work. I get the shop at 5:00am and work straight through till 4:00pm or 5:00pm. Go, go, go practically the whole time. Ive made a couple of small changes to my process recently and actually get some time to breathe in there. Did you notice some of the very soft or rock hard tofu over the past month as I was figuring it out? [Ed.: Yes, actually, I did.] Mainly, I changed how I add the coagulant, the amount of water I cook with, and the temperature to which I heat and curdle the soymilk. I am ready to make some other ...
Performance of Moringa oleifera seed extract as primary coagulant and as coagulant aid with alum in clarification of turbid coloured water was examined and compared with the performance of alum. M. oleifera seed extract is effective as prime coagulant and as coagulant aid with alum. Compared with alum (residual filtrate turbidity 2 NTU and residual colour 3 TCU), it produces water with slightly higher residual filtrate turbidity (4 and 3 NTU) and residual colour (15 and 13 TCU), but the residual turbidity and residual colour are within the WHO (2006) drinking water guideline values for turbidity (5 NTU) and colour (15 TCU). ...
Adaptive hemocompatible coatings. We have demonstrated that bio-responsive polymer architectures can empower medical therapies by engaging molecular feedback-response mechanisms resembling the homeostatic adaptation of living tissues to varying environmental constraints: A blood coagulation-responsive hydrogel system was shown to deliver heparin in amounts triggered by the environmental levels of thrombin, the key enzyme of the coagulation cascade, which--in turn- becomes inactivated due to released heparin. The bio-responsive hydrogel quantitatively quenches human blood coagulation over several hours in the presence of pro-coagulant stimuli. Release analogously triggered by the early coagulation factors Xa or XIIa enhanced the efficiency of the released anticoagulant, and silver-containing hydrogel layers provided a combination of hemocompatibility and long-term antiseptic capacity. Figure modified from Maitz MF et al. Biomaterials 2017 Back. ...
Science & Technology, Life Sciences & Biomedicine, Transplantation, Urology & Nephrology, TRANSPLANTATION, UROLOGY & NEPHROLOGY, chronic renal disease, dyslipidaemia, factor VII genotype, factor VII coagulant activity (VIIc), interleukin 6, prothrombin fragment F1+2, TRIGLYCERIDE-RICH LIPOPROTEINS, CARDIOVASCULAR RISK-FACTORS, ISCHEMIC-HEART-DISEASE, ACTIVATED FACTOR-VII, UREMIC PATIENTS, GEMFIBROZIL, FAILURE, POLYMORPHISM, THROMBOSIS, STATE ...
Containers containing coagulants[edit]. *Gold or "tiger" red/black top: clot activator and gel for serum separation ...
... cationic coagulants neutralize the anionic colloids). At this value (0), the coagulant dose can be said to be optimum.[1] ... The dose of the coagulant to be used can be determined via the Jar Test.[1][6] The jar test involves exposing same volume ... A coagulant (typically a metallic salt) with the opposite charge is added to the water to overcome the repulsive charge and " ... Iron and aluminium salts are the most widely used coagulants but salts of other metals such as titanium and zirconium have been ...
Latex coagulantEdit. Calcium nitrate is a very common coagulant in latex production, especially in dipping processes. Dissolved ... N. C. Dafader, Y. N. Jolly, M. E. Haque, F. Akhtar & M. U. Ahmad: The Role of Coagulants on the Preparation of Dipped film from ...
Pekmez is made of grapes, fig (Ficus carica) and mulberry (Morus spp.) juices, condensed by boiling with coagulant agents. ...
This binding domain is essential for coagulant activity. People with high levels of factor VIII are at increased risk for deep ... This complex is the pro-coagulant factor VIIIa. FVIII is a glycoprotein procofactor. Although the primary site of release in ...
The saliva of Ixodes holocyclus also contains anti-coagulant.[58] Domestic pets[edit]. Dogs and cats on the East Coast of ...
The calcium sulfate hydrates are used as a coagulant in products such as tofu. Up to the 1970s, commercial quantities of ... About tofu coagulant. Retrieved 9 Jan. 2008. Whitehaven Coast Archeological Survey Gypsum, USGS, 2008 "NASA Mars Opportunity ...
He was their longest serving Fellow: 1929 to 1995 (66 years). He did extensive work on anti-coagulants. In 1959 he was a co- ...
Targeted treatment of deep water with coagulants. Especially in respect of drinking water production, deep-water aeration ...
Purification, properties and coagulant actions". J. Biol. Chem. 261: 8830-8835. PMID 3522580. Venombin AB at the US National ...
The addition of inorganic coagulants such as aluminum sulfate (or alum) or iron (III) salts such as iron(III) chloride cause ... In fact, coagulation and flocculation processes are ongoing once the metal salt coagulants are added.[8]:74-5 ... Organic polymers were developed in the 1960s as aids to coagulants and, in some cases, as replacements for the inorganic metal ... Within seconds, negative charges on the particles are neutralized by inorganic coagulants. Also within seconds, metal hydroxide ...
... the prostatic fluid contains a coagulant. This mixes with and coagulates semen during copulation to form a mating plug that ...
Coumarin derivatives are also used medicinally, as anti-coagulants. B.L. Axtell from research by R.M. Fairman (1992). "Part 1: ...
It also has potent coagulants as well as myotoxins. It will readily bite and is known for its foul disposition and defensive ...
Some doctors use anti-coagulants to prevent a clot. On the other hand, some doctors only give steroids and immunosuppressants ...
Some surgeons suggest the use of stronger anti-coagulants. The disadvantage to the Dor procedure is that it places synthetic ... It is recommended that the patient be placed on a mild anti-coagulant post operation to reduce the risk of blood clots. ...
"Coagulant protein of Russell's viper venom". Methods Enzymol. 45: 191-205. doi:10.1016/s0076-6879(76)45019-x. PMID 1011991. ...
It is added before the coagulant. Calcium chloride is used to prevent cork spot and bitter pit on apples by spraying on the ...
... venoms possess potent neurotoxins, coagulants, haemolysins, and myotoxins. Symptoms of a bite include localized ...
Coagulant and fibrinolytic activity of animal venoms; determination of coagulant and fibrinolytic index of different species. ...
It may also be used as a coagulant for making tofu.[15] ...
Coagulation can be achieved by a chemical coagulant or by electrical methods. Alum [Al2(SO4)3.18H2O] is such a chemical ... In the EC process, the coagulant is generated in situ by electrolytic oxidation of an appropriate anode material. In this ... Alum, lime and/or polymers have been the chemical coagulants used. These processes, however, tend to generate large volumes of ...
Physicochemical methods are based on the use of coagulants and adsorbents. Coagulants promote the coarsening and precipitation ...
The pure sheep milk is curdled using a coagulant found in the pistils of cardoon (Cynara cardunculus). This ingredient lends a ... coagulant) is used. These two conditions result in a milder cheese. It differs from Queijo Serra da Estrela, made in ...
Stocker, K.; Barlow, G.H. (1976). "The coagulant enzyme from Bothrops atrox venom (batroxobin)". Methods Enzymol. 45: 214-223. ...
... screening for anti-platelet and anti-coagulant potency; and collaborating with different groups in search of novel strategies ...
Keywords: soy milk; milk-coagulant activity; Moringa oleifera; seeds soy milk; milk-coagulant activity; Moringa oleifera; seeds ... Utility of Milk Coagulant Enzyme of Moringa oleifera Seed in Cheese Production from Soy and Skim Milks. María Alejandra Sánchez ... "Utility of Milk Coagulant Enzyme of Moringa oleifera Seed in Cheese Production from Soy and Skim Milks." Foods 6, no. 8: 62. ... Utility of Milk Coagulant Enzyme of Moringa oleifera Seed in Cheese Production from Soy and Skim Milks. Foods 2017, 6, 62. ...
Moringa oleifera SEED DERIVATIVES AS POTENTIAL BIO-COAGULANT FOR MICROALGAE Chlorella Sp. HARVESTING ... it was found that the zeta potential values of mixed microalgae-coagulant suspension shows positive correlation on the ... Moringa oleifera SEED DERIVATIVES AS POTENTIAL BIO-COAGULANT FOR MICROALGAE Chlorella Sp. HARVESTING. Malaysian Journal of ... study was performed to investigate the potentialities of Moringa oleifera seed derivatives as an environmentally bio-coagulant ...
The Use of Moringa oleifera as a Natural Coagulant for Water and Wastewater Treatment. Department of Engineering, University of ... Assessment of Drinking Water Treatment using Moringa oleifera Natural Coagulant-A Minor Field Study in Maputo, Mozambique. ... Moringa oleifera as a Natural Coagulant. Affordable Water Supply & Sanitation: Proceedings of the 20th WEDC Conference, Colombo ... Using Moringa seeds as coagulants in developing countries. J. Am. Water Works Assoc. 80:43‐50. ...
Moringa acts as a coagulant attaching itself to harmful material and bacteria. It is believed that this process is taking place ...
1158_40 Evaluation of natural coagulant Moringa oleifera Lam. in the treatment of dairy wastewater at different pH ...
Anti-coagulants synonyms, Anti-coagulants pronunciation, Anti-coagulants translation, English dictionary definition of Anti- ... coagulants. n. A substance that slows or prevents the clotting of blood. adj. Acting as an anticoagulant. an′ti·co·ag′u·la′tive ... Anti-coagulants - definition of Anti-coagulants by The Free Dictionary https://www.thefreedictionary.com/Anti-coagulants ... redirected from Anti-coagulants). Also found in: Thesaurus, Medical, Encyclopedia. an·ti·co·ag·u·lant. (ăn′tē-kō-ăg′yə-lənt, ăn ...
coagulant has 99 repositories available. Follow their code on GitHub. ...
New Anticoagulants for AF Results of a new meta-analysis indicate that for patients with atrial fibrilation, treatment with one of the new oral anticoagulants rather than warfarin is more effective for preventing stroke and less risky in terms of intracranial bleeding.. ...
Ortho-anthranilamide derivatives as anti-coagulants. US6150382 *. May 21, 1999. Nov 21, 2000. Berlex Laboratories, Inc.. Thio ... R3, and R4 have meanings as defined herein, or a pharmaceutically acceptable salt thereof, are useful as anti-coagulants. ... The compounds of the invention are inhibitors of factor Xa and factor IIa and therefore useful as anti-coagulants in treating ... Benzamidine derivatives and their use as anti-coagulants. US6350746. Dec 8, 1999. Feb 26, 2002. Berlex Laboratories, Inc.. ...
The treatment of a woman left severely disabled by a stroke after medics failed to offer her long-term blood thinning drugs is criticised.
Anti-coagulant synonyms, Anti-coagulant pronunciation, Anti-coagulant translation, English dictionary definition of Anti- ... coagulant. n. A substance that slows or prevents the clotting of blood. adj. Acting as an anticoagulant. an′ti·co·ag′u·la′tive ... redirected from Anti-coagulant). Also found in: Thesaurus, Medical, Encyclopedia.. Related to Anti-coagulant: anticoagulant ... Anti-coagulant - definition of Anti-coagulant by The Free Dictionary https://www.thefreedictionary.com/Anti-coagulant ...
Inorganic coagulants are typically aluminum or iron salts used for water treatment for different applications: e.g. potable ... The European Inorganic Coagulants Producers Association (INCOPA) is a sector group of Cefic, the European Chemical Industry ...
Coagulant Drugs. Coagulant drugs, also called anti-inhibitor coagulant complexes, also help regulate blood coagulation. Some ... Because coagulant drugs contain vitamin K-depending pro-coagulant factors, vitamin K often interacts with these coagulant drugs ... Effect of Vitamin K on Anti-Coagulant Drugs. Individuals taking anti-coagulants -- drugs that prevent excessive blood clotting ... Coagulant Drugs & Vitamin K by SYLVIE TREMBLAY, MSC Last Updated: Oct 03, 2017. ...
Find polyelectrolyte coagulant articles on Environmental XPRT, the worlds largest environmental industry marketplace and ... polyelectrolyte coagulant Articles. Related terms for "polyelectrolyte coagulant ": coagulant articles , polyelectrolyte ... Evaluation of industrial dyeing wastewater treatment with coagulants and polyelectrolyte as a coagulant aid. Wastewater is the ... Home water treatment by direct filtration with natural coagulant ABSTRACTSeeds of the plant species Strychnos potatorum and ...
Due to inconsistencies between the drug labels on DailyMed and the pill images provided by RxImage, we no longer display the RxImage pill images associated with drug labels. We anticipate reposting the images once we are able identify and filter out images that do not match the information provided in the drug labels. ...
Anti-inhibitor Coagulant Complex reference guide for safe and effective use from the American Society of Health-System ... Anti-inhibitor coagulant complex Intravenous (Advanced Reading). Professional resources. *Anti-inhibitor Coagulant Complex ( ... Possible anamnestic response to trace amounts of factor VIII contained in anti-inhibitor coagulant complex.24 25 34 35 41 42 70 ... Anti-inhibitor Coagulant Complex. Class: Hemostatics. VA Class: BL500. Brands: Feiba VH ...
What is Coagulants? Meaning of Coagulants as a legal term. What does Coagulants mean in law? ... Definition of Coagulants in the Legal Dictionary - by Free online English dictionary and encyclopedia. ... redirected from Coagulants). Also found in: Dictionary, Thesaurus, Medical, Encyclopedia. See: adhesion, agglomeration, ... The pH of the water can affect the performance of all the coagulants evaluated.. Reducing the public health risk of ...
Best coagulants flocculants polymer and coagulants flocculants polymer manufacturers - 1200 coagulants flocculants polymer ... coagulants flocculants polymer. 1,200 Results. All Verified coagulants flocculants polymer suppliers & coagulants flocculants ... With the coagulant, flocculant use, mainly through the sweep, bridging role in suspended matter surface, significantly enhanced ... Polyacrylamide PAM as Coagulant Flocculant in Water treatment 【Product Description】 CAS No: 9003-05-8 MF: (C3H5NO)n Molecular ...
Professional guide for Anti-inhibitor Coagulant Complex (Human). Includes: pharmacology, pharmacokinetics, contraindications, ... Anti-inhibitor coagulant complex Intravenous (Advanced Reading). Professional resources. *Anti-inhibitor Coagulant Complex ( ... Note: Anti-inhibitor coagulant complex (Human) contains mainly non-activated therapeutic levels of factors II, IX, and X and ... Monitor patients receiving anti-inhibitor coagulant complex for signs and symptoms of thromboembolic events, especially if more ...
ULTRION Coagulants were developed to handle the wide seasonal variation of surface waters to produce a consistent, high quality ... ULTRION™ Coagulants ULTRION™ Coagulants were developed to handle the wide seasonal variation of surface waters to produce a ...
Snake venom inspires coagulant gel. By Andrew Wade 27th October 2015 11:07 am 11th April 2017 12:28 pm ... First recognised in 1936 for its coagulant capabilities, batroxobin is particularly useful for treating patients who have taken ... particularly in difficult cases in which the patient is taking heparin or other anti-coagulants," said Hartgerink. "SB50 takes ... the anti-coagulant drug heparin.. "Theres a lot of different things that can trigger blood coagulation, but when youre on ...
Sodium Silicate for Tube Winding Adhesives from the EngNet Engineering directory and search engine. Find suppliers, manufacturers and distributors for Sodium Silicate for Tube Winding Adhesives.
Find organic coagulant (microfiltration - water and wastewater) articles on Environmental XPRT, the worlds largest ... The ability of in-line coagulation pretreatment with high-basicity polyaluminum chloride (PACl) coagulants to enhance virus ... types of coagulants-aluminum-based PAX and iron-based PIX-and G-values) were studied. The rate of irreversible fouling ...
... short lecture from haematologist Dr Ali Bazargan provides an easy-to-understand guide to navigate the world of anti-coagulant ... How many different anti-coagulants are available for the treatment of thrombosis? This ... How many different anti-coagulants are available for the treatment of thrombosis? This short lecture from haematologist Dr Ali ... Bazargan provides an easy-to-understand guide to navigate the world of anti-coagulant acronyms. Come and explore what LMWH, VKA ...
Meaning of coagulants. What does coagulants mean? Information and translations of coagulants in the most comprehensive ... Definition of coagulants in the Definitions.net dictionary. ... What does coagulants mean?. Definitions for coagulants. Here ... Discuss these coagulants definitions with the community:. Word of the Day. Would you like us to send you a FREE new word ... Coagulants. Exogenous substances used to promote blood coagulation. The endogenous BLOOD COAGULATION FACTORS are considered to ...
  • The results showed that the pre-polymerized coagulants of iron, such as poly-ferric sulfate and poly-ferric silicate chloride, were very efficient for As(V) removal. (mdpi.com)
  • With regard to As(III) removal, among all examined coagulants, including the conventional ferric chloride, only the poly-ferric sulfate (PFS) was able to reduce As(III) to concentrations below the drinking water regulation limit of 10 μg/L. In contrast, all tested composite coagulants based on aluminum were not capable of removing efficiently both species of arsenic. (mdpi.com)
  • Here, the addition of a coagulant such as ferric sulphate, converts the phosphate solution into insoluble phosphate compounds which can then be isolated. (watson-marlow.com)
  • This uses the current phosphate load to automatically calculate the necessary quantities of ferric sulphate coagulant required, so that we can reliably observe the necessary discharge values. (watson-marlow.com)
  • Ferric sulfate and Ferric Chloride are used as a coagulants or flocculants for water treatment production, and several other applications such as sludge conditioning, odor prevention and more. (pencco.com)
  • Conventional coagulants such as lime, alum and ferrous sulfate, or six doses for each coagulant type i.e., 5-30, 10-60 and 25-150 mg L -1 , respectively, were used in the sludge conditioning processes for the enhancement of the sludge dewatering capacity. (teraganix.com)
  • Solubility in deionized water was studied at 20 and 5°C between pH 4 and 9 for seven coagulants: alum, a low and a high basicity polyaluminium chloride (PACl) containing no sulphate, a medium and a high basicity PACl with sulphate, aluminium chlorohydrate and a low basicity polyaluminium sulphate (PAS). (iwaponline.com)
  • For example, the colloidal particles are negatively charged and alum is added as a coagulant to create positively charged ions. (wikipedia.org)
  • Two anti-coagulants were used in the study, K3 EDTA and lithium heparin (LiHep), and slides were made either immediately or after periods of 4-6 hours, with the test results being analyzed to determine whether there was any correlation between the anticoagulant used and the sample processing time. (thefreedictionary.com)
  • CATEGORY CLASS Anti coagulant PURPOSE OF MEDICATION Expected Pharmacological Action Therapeutic Use prevents conversion of fibrinogen and prot- prevents of DVT, DE, MI, open heart surgery hrombin to thrombin by enhancing inhibitory effects of antithrombin III (ATI, p. 191) A-FIB, anticoagulant in dialysis and transfusion procedures, treatment of DIC. (coursehero.com)
  • There are other types of tubes used for various tests that are ordered by a healthcare professional, but are not classified as a coagulant or anticoagulant. (brighthub.com)
  • Jeanette Bailey, 53, an NHS worker for 35 years, developed a painful muscle condition due to an overdose of anti-coagulant drugs while in hospital but was told others needed to be treated first. (thefreedictionary.com)
  • The findings indicated that the patients with atrial fibrillation (an abnormal heart rhythm), who were taking anti-coagulant drugs to prevent blood clots at the start of the study had a 29 per cent lower risk of developing dementia than patients, who were not on an anti-coagulant treatment. (thefreedictionary.com)
  • The atrial fibrillation market report provides market size estimates (Revenue USD million - 2013 to 2020) for key market segments based on treatment type (pharmacological - anti-arrhythmic drugs, anti-coagulant drugs and non-pharmacological - catheter ablation based on cryoablation, HIFU, laser, microwave and radiofrequency, maze surgery, and electric cardioversion), and forecasts growth trends (CAGR% - 2016 to 2020). (thefreedictionary.com)
  • Individuals at risk of bleeding or clotting conditions may take coagulant drugs to help control the thickness of their blood and prevent illness. (livestrong.com)
  • However, nutrients obtained from your diet or from dietary supplements, such as vitamin K, may affect the activity and efficacy of coagulant drugs, and can affect your drug dosage, according to the Linus Pauling Institute at Oregon State University. (livestrong.com)
  • Always talk to your doctor about any vitamin supplements before taking coagulant drugs. (livestrong.com)
  • Because coagulant drugs contain vitamin K-depending pro-coagulant factors, vitamin K often interacts with these coagulant drugs within your system. (livestrong.com)
  • Though the drugs may contain some activated coagulant factors, other precursors may require vitamin K in your system to produce biologically active coagulating factors to allow blood clotting. (livestrong.com)
  • Individuals taking anti-coagulants -- drugs that prevent excessive blood clotting -- should also monitor their vitamin K levels. (livestrong.com)
  • The University of Maryland Medical Center explains that large doses of vitamin K supplements may override or inhibit the action of some anti-coagulant drugs, putting the patient at risk for blood clot formation. (livestrong.com)
  • The vitamin helps activate these coagulant proteins by performing chemical modifications on amino acids within the protein, changing the proteins from inactive to their biologically active forms as needed. (livestrong.com)
  • Although the use of natural coagulant protein in drinking water treatment has been discussed for a long time, the method is still not in practice, probably due to availability of material and limited knowledge. (diva-portal.org)
  • Among the operational parameters, slow mixing time significantly influenced performance of natural coagulant. (iwaponline.com)
  • Turbidity and bacteria ( Escherichia coli ) removal efficiency of the purified M. oleifera and metal coagulants were similar. (iwaponline.com)
  • Our results suggest that intermediate polymers formed during hydrolysis of the aluminum coagulants sorbed strongly to viruses, either rendering them inactive or preventing infectivity. (nii.ac.jp)
  • Coagulant aids (polymers that bridge the colloids together) are also often used to increase the efficiency of the process. (wikipedia.org)
  • The total infectious virus concentration in the suspension of floc particles that eventually formed by dosing with coagulant was measured after the floc particles were dissolved by raising the pH with an alkaline beef extract solution. (nii.ac.jp)
  • A liquid designed to function as an effective primary coagulant for the removal of sediment from surface waters, and from many types of industrial wastewaters. (tpub.com)
  • Hart, which has already had success in the manufacture of blood coagulants for administration by GPs in community practices is increasingly moving into supplying products for the surgical management of bleeding patients. (thefreedictionary.com)
  • We doesn't provide blood coagulant medication products or service, please contact them directly and verify their companies info carefully. (hfcletter.com)
  • We doesn't provide coagulants used in water treatment products or service, please contact them directly and verify their companies info carefully. (chinacomputerparts.com)
  • Iron based coagulants are used in reducing the biological decomposition products at low pH. (sbwire.com)
  • Still, BPOM requires health supplements that contain more EPA than DHA to carry a warning about consuming anti-coagulants alongside products high in EPA, as it believes this results in a significant blood-thinning effect. (nutraingredients.com)
  • The calcium sulfate hydrates are used as a coagulant in products such as tofu. (wikipedia.org)
  • Here we describe that the interaction of pro-coagulant MVs with bacteria of the species Streptococcus pyogenes is part of the early immune response to the invading pathogen. (lu.se)
  • The Brazilian lancehead is one of several South American pit vipers that produce venom that has proven to be a powerful blood coagulant. (theengineer.co.uk)
  • It is important for parents who are planning to bank their baby's cord blood to ask the cord blood bank what type of anti-coagulant it uses in its cord blood collection bag. (cryo-cell.com)
  • Because of heparin's drawbacks, CPD has been nearly unanimously chosen as the best anti-coagulant for cord blood banking. (cryo-cell.com)
  • In addition, liquid CPD is the preferred anti-coagulant of Dr. Joanne Kurtzberg, a well-respected researcher at Duke University Medical Center, and Pablo Rubenstein, the founder and current director of the National Cord Blood Program, the first public cord blood bank. (cryo-cell.com)
  • This invention relates to coagulants or clotting agents and more particularly relates to prepackaged bandages or absorbent pads saturated with a coagulant solution so as to be effective in clotting blood at the site of a wound in a reliable and efficient manner. (google.es)
  • The market for blood coagulants is growing due to factors such as increasing awareness and prevalence of bleeding disorders, rise in accidents and surgeries, rise in chemotherapy, greater screening of patients with hemophilia and other blood disorders, excellent reimbursement for these class of medicines and their inclusion in essential medicines list etc. (abnewswire.com)
  • The market for blood coagulants favors companies with strong research and development and hi tech in-house skills. (abnewswire.com)
  • Coagulant blood tests are performed to test an individual's ability to clot properly. (brighthub.com)
  • Previous studies have shown that stimulation of whole blood or peripheral blood mononuclear cells with bacterial virulence factors results in the sequestration of pro-coagulant microvesicles (MVs). (lu.se)
  • If you take anti-coagulant medications, such as warfarin, you must disclose any vitamin K supplementation to your doctor to determine an appropriate mediation dosage and prevent harmful side effects. (livestrong.com)
  • The number of anti-coagulant medications such as Warfarin has risen significantly over recent years. (borno-chemists.com)
  • I am writing to ask if you or your loved one are taking both Celebrex and Warfarin (or a similar anti-coagulant) and what your experience has been with them. (blogspot.com)