Apiaceae
A large plant family in the order Apiales, also known as Umbelliferae. Most are aromatic herbs with alternate, feather-divided leaves that are sheathed at the base. The flowers often form a conspicuous flat-topped umbel. Each small individual flower is usually bisexual, with five sepals, five petals, and an enlarged disk at the base of the style. The fruits are ridged and are composed of two parts that split open at maturity.
Coumarins
Anti-allergic effects of cnidii monnieri fructus (dried fruits of Cnidium monnieri) and its major component, osthol. (1/10)
Anti-allergic effects (types I and IV) of the 70% ethanol extract (CM-ext) obtained from Cnidii Monnieri Fructus (dried fruits of Cnidium monnieri) were investigated on 48 h homologous passive cutaneous anaphylaxis (PCA), 2, 4-dinitrofluorobenzene (DNFB)-induced contact dermatitis and picryl chloride (PC)-induced contact dermatitis in experimental animals. CM-ext showed inhibitory effects on these allergic models. Osthol isolated from CM-ext also had the inhibitory effects. These results suggested that Cnidii Monnieri Fructus might be useful as an agent for allergic diseases and that its anti-allergic effect was partially attributable to a coumarin derivative, osthol. (+info)Total coumarins from fruits of Cnidium monnieri inhibit formation and differentiation of multinucleated osteoclasts of rats. (2/10)
AIM: To determine the effects of TCFC (total comarins from the fruits of Cnidium monnieri) on the activity of osteoclasts in vitro. METHODS: Osteoclasts isolated from rat marrow cells were co-cultured with osteoblasts under the 1,25-dihydroxyvitamine D3. The tartrate-resistant acid phosphatase (TRAP) stain was used to identify osteoclast morphology. The activity of TRAP was measured by p-nitrophenyl sodium phosphate assay. The resorption pit area on the bone slices formed by osteoclasts was measured by computer image processing. Calcium concentration in the medium of co-culture of bone slices and osteoclasts was determined by atomic absorption spectra. RESULTS: TCFC 2.5-25 mg/L inhibited osteoclast formation and differentiation. TCFC 0.25-25 mg/L inhibited TRAP activity of osteoclasts and TCFC 25 mg/L decreased the TRAP activity by 26.3 % and 24.1 % after 48 h and 72 h, respectively. TCFC 25 mg/L decreased the osteoclastic bone resorption pit area by 25.05 % and Ca2+ release from bone slices by 41.73 %. CONCLUSION: TCFC reduced the bone lose by decreasing the osteoclast formation, its TRAP activity, and osteoclastic bone resorption. (+info)Ethyl acetate soluble fraction of Cnidium officinale MAKINO inhibits neuronal cell death by reduction of excessive nitric oxide production in lipopolysaccharide-treated rat hippocampal slice cultures and microglia cells. (3/10)
In the present work, we found that the ethyl acetate-soluble fraction of Cnidium officinale MAKINO (COEA) decreased nitric oxide (NO) production in the lipopolysaccharide (LPS)-stimulated BV-2 and primary microglia and suppressed expression of inducible nitric oxide synthase (iNOS) in BV-2 cells with the same pattern of NO production. In addition, we showed that excessive NO production played an important role in neuronal cell death in LPS-treated rat hippocampal slice cultures. Our data suggest that the COEA inhibits neuronal cell death by reduction of excessive NO production in LPS-treated rat hippocampal slice cultures. The ethyl acetate-soluble fraction of C. officinale reduced propidium iodide uptake and NO production in cultured media at the same time. (+info)Enemy-free space maintains swallowtail butterfly host shift. (4/10)
Natural enemies can be significant sources of mortality for herbivorous insects and therefore important agents of natural selection. One might expect selection to favor herbivores that escape from their natural enemies into enemy-free space. Although this is an appealing idea, it has received little empirical support, and no studies have documented enemy-free space as part of a nonagricultural, nonartificial host shift. The Alaskan swallowtail butterfly, Papilio machaon aliaska, uses as host plants a species in the family Apiaceae (Cnidium cnidiifolium) along with two Asteraceae species (Artemisia arctica and Petasites frigidus). I analyzed growth and survival of P. m. aliaska larvae in the field on the three host plants in treatments that either exposed or protected them from predators. I found that, in the presence of predators, larval survival is greater on the novel hosts (Asteraceae) than on the ancestral host (Apiaceae), but that in the absence of predators survival and growth are greater on the ancestral host. These results are a demonstration of enemy-free space as a mechanism for maintaining a naturally occurring host shift. (+info)Comparison of micellar electrokinetic capillary chromatography and high performance liquid chromatography on fingerprint of Cnidium monnieri. (5/10)
In our studies, micellar electrokinetic capillary chromatography (MEKC) was employed in fingerprint analysis of Cnidium monnieri for the first time. Average chromatography of 10 batches Cnidium monnieri from Jiangsu province, China, which have long been considered as the original and genuine herbal medicine, was first established as the characteristic fingerprint. Within 25 min the major effective components were separated by 18 mM borate, 12 mM phosphate and 50 mM SDS (pH 9.2) containing 20% methanol. The relative standard deviations of migration times and peak areas were less than 5%. As a new approach of fingerprint, MKCE was compared to the conventional approach-HPLC in our experiments. The fingerprint developed by HPLC comprised 8 peaks that were collected within 40 min. Relative standard deviation (RSD) values of retention times of corresponding peaks in HPLC analysis were very small (maximum 3% and average 0.9%). In conclusion, each two methods had its advantages and disadvantages. Furthermore, besides HPLC, MEKC as a feasible method, could be used in the development of fingerprint of Cnidium monnieri. (+info)Therapeutic effect of osthole on hyperlipidemic fatty liver in rats. (6/10)
AIM: To study the effects of osthole on hyperlipidemic fatty liver and investigate the possible mechanisms. METHODS: A rat model with hyperlipidemic fatty liver was successfully established by feeding fatty milk for 6 weeks. The experimental rats were then treated with 5-20 mg/kg osthole for 6 weeks. The mouse hyperlipidemic model was induced by feeding fatty milk when they were treated with 10-20 mg/kg osthole for 3 weeks. RESULTS: After treatment with osthole, the levels of rat serum total cholesterol (TC), triglyceride (TG) and low density lipoprotein-cholesterol significantly decreased as compared with the fatty liver model group (P< 0.05 or P< 0.01). Hepatic weight and its coefficient, the hepatic tissue contents of TC, TG, and malondialdehyde, also significantly decreased (P< 0.05 or P< 0.01). In fatty milk-induced hyperlipidemic mice, the post-heparin plasma activities of lipoprotein lipase (LPL), hepatic lipase (HL), and total lipase (TL) significantly increased after treatment with 10-20 mg/kg osthole for 3 weeks (P< 0.05 or P< 0.01). Importantly, the histological evaluation of rat liver demonstrated that osthole dramatically decreased lipid accumulation (P< 0.01). CONCLUSION: Osthole was found to have therapeutic effects on fatty milk-induced rat fatty liver; the mechanisms might be associated with its anti-oxidation and the elevation of the activities of LPL and HL. (+info)Molecular identification of "Chuanxiong" by nucleotide sequence and multiplex single base extension analysis on chloroplast trnK gene. (7/10)
Chloroplast trnK gene sequences of Cnidium officinale and Ligusticum chuanxiong were determined to establish an effective method for identifying Japanese Senkyu and Chinese Chuanxiong, the two which have the same drug name in Chinese characters, similar external feature, but different botanical origins. Three sites of nucleotide differences were found between these 2 species at positions 767,924 and 964 from upstream in trnK gene sequence, allowing molecular identification of the two plants and crude drugs. Further, three kinds of specific primers of 14 mer, 23 mer and 30 mer long were designed to detect these 3 sites of marker nucleotides. By using multiplex single base extension (MSBE) analysis with the 3 specific primers, C. officinale and L. chuanxiong could be distinguished clearly by the electrophoretograms, where 3 peaks with different color of ddTMP, ddCMP and ddTMP were observed in case of C. officinale and those of ddGMP, ddAMP and ddGMP in L. chuanxiong. Moreover, trnK gene sequence of "Dongxiong," a kind of Chuanxiong cultivated in Northeast China, suggested that its botanical origin was C. officinale. (+info)Enhanced antitumor efficacy of cisplatin in combination with HemoHIM in tumor-bearing mice. (8/10)
(+info)
SNU Open Repository and Archive: Metabolomics Study in Cnidium officinale Accessions by Multivariate Analysis
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Cnidium
... is a genus of flowering plants in the Apiaceae, native to Eurasia, Africa and North America. It has 4 or 5 species. ... Alternative, Herbal Medicine - Cnidium Seeds v t e v t e (Articles with short description, Short description is different from ...
Cnidium monnieri
"Cnidium monnieri". Retrieved 3 January 2016. "Cnidium monnieri". Hortipedia. Retrieved 3 January 2016. "Cnidium monnieri ( ... Cnidium monnieri (L.) Cusson ex Juss., Monnier's snowparsley, is a flowering plant species in the genus Cnidium. Also known as ... Cnidium monnieri is a species in the genus Cnidium which contains approximately 11 to 35 species and belongs to the family[ ... Cnidium monnieri at the United States Department of Agriculture Cnidium monnieri in the Flora of China Wikispecies has ...
Cnidium cnidiifolium
... is a species of flowering plant in the parsley family, Apiaceae. Its common names include northern hemlock ... Cnidium cnidiifolium. NatureServe. 2013. Hultén, E. Flora of Alaska and Neighboring Territories. 1968. v t e (Articles with ... "Cnidium cnidiifolium". Germplasm Resources Information Network (GRIN). Agricultural Research Service (ARS), United States ...
Depressaria pulcherrimella
Other recorded food plants include Cnidium, Bunium and Valeriana species. Fauna Europaea "microlepidoptera.nl". Archived from ...
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Dactylorhiza ochroleuca (Wüstnei ex Boll) Holub Cnidium dubium (Schkuhr) Thell. Chaerophyllum hirsutum L. Dianthus borbasii ...
Xanthotoxol
It is one of the major active ingredients in Cnidium monnieri. Xanthotoxol O-methyltransferase (8-hydroxyfuranocoumarin 8-O- ...
Agonopterix quadripunctata
The larvae feed on Seseli and Cnidium species, including Cnidium dubium. Fauna Europaea Swedish Moths Insecta Norvegiae ...
List of Apiaceae genera
Carlesia Dunn Chymsydia Albov Cnidiocarpa Pimenov Cnidium Cusson Coaxana J.M.Coult. & Rose Cortia DC. Cortiella C. Norman ...
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The larvae feed on Daphne cnidium, Helianthemum, Pistacia lentiscus and Dorycnium germanicum. tortricidae.com Wikispecies has ...
Molopospermum
2015). "Cnidium monnieri: A Review of Traditional Uses, Phytochemical and Ethnopharmacological Properties". Am J Chin Med. 43 ( ... Cnidium monnieri - may possess aphrodisiac properties. The chemistry of Molopospermum suggests that it may possess ...
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Cnidium rhizome, Cnidium officinale or Szechuan lovage); 2 parts dong quai (Angelica sinensis or female ginseng); 1 part tian ...
Imperatorin
2010-11-17). "Antifibrotic activity of coumarins from Cnidium monnieri fruits in HSC-T6 hepatic stellate cells". Journal of ... Cnidium monnieri, Incarvillea younghusbandii, and Zanthoxylum americanum mill. It is biosynthesized from umbelliferone, a ...
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Osthol
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Monnieri
Some species with the epithet are: Bacopa monnieri - water hyssop Cnidium monnieri - Monnier's snowparsley Stachys monieri - ...
List of MeSH codes (B06)
... cnidium MeSH B06.388.100.075.211 - coriandrum MeSH B06.388.100.075.233 - cuminum MeSH B06.388.100.075.288 - daucus carota MeSH ...
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MacKenzie's water-hemlock Cnidium cnidiifolium - Jakutsk snow parsley Conioselinum chinense - Chinese hemlock-parsley ...
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Extract3
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- 3. Skin Rashes and Infections can be addressed with a topical solution of Cnidium Extract. (fineskybiotech.com)
- This effect has not been widely studied so if this is an issue you have or fear it might be that you supplement your medical routine by adding Cnidium extract as a secondary supplement. (fineskybiotech.com)
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- ABSTRACT HPC 03 is herbal formula that consists of extracts from Angelica gigas, Cnidium officinale Makino and Cinnamomum cassia Presel. (nrresource.org)
- Evaluation of fetal and neonatal outcomes after ingestion of Cnidium root (Cnidium officinale Makino) during pregnancy. (cdc.gov)
Chuang Zi1
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Monnier1
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Licorice1
- Tang-kuei root (dang gui), Peach kernel (tao ren), Cnidium root (chuan xiong), Chinese licorice root (gan cao), Ginger (gan jiang). (acuatlanta.net)
Erectile dysfunction1
- Cnidium is most commonly used for helping with libido and sexual performance, ED (erectile dysfunction), and skin conditions, but there is no good scientific evidence supporting any of these uses. (malehealthreview.com)
Major1
- 1. Low intimate drive in men and women is one of the major Cnidium benefits. (fineskybiotech.com)
Make1
- It is important to have an experienced herbalist help you make the Cnidium paste for external use, at least the first time, so you get it right. (fineskybiotech.com)
Activities1
- Chemical compositon, antibacterial and antioxidant activities of Cnidium silaifolium ssp. (csic.es)
Improve1
- This may be the second most common of the Cnidium benefits and one that may improve even more with regular use. (fineskybiotech.com)