Venoms from jellyfish; CORALS; SEA ANEMONES; etc. They contain hemo-, cardio-, dermo- , and neuro-toxic substances and probably ENZYMES. They include palytoxin, sarcophine, and anthopleurine.
A phylum of radially symmetrical invertebrates characterized by possession of stinging cells called nematocysts. It includes the classes ANTHOZOA; CUBOZOA; HYDROZOA, and SCYPHOZOA. Members carry CNIDARIAN VENOMS.
A class in the phylum CNIDARIA which alternates between polyp and medusa forms during their life cycle. There are over 2700 species in five orders.
The order Actiniaria, in the class ANTHOZOA, comprised of large, solitary polyps. All species are carnivorous.
Venoms from snakes of the subfamily Crotalinae or pit vipers, found mostly in the Americas. They include the rattlesnake, cottonmouth, fer-de-lance, bushmaster, and American copperhead. Their venoms contain nontoxic proteins, cardio-, hemo-, cyto-, and neurotoxins, and many enzymes, especially phospholipases A. Many of the toxins have been characterized.
A genus of freshwater polyps in the family Hydridae, order Hydroida, class HYDROZOA. They are of special interest because of their complex organization and because their adult organization corresponds roughly to the gastrula of higher animals.
A double-walled capsule found in jellyfish and other CNIDARIA whose functions include prey capture, defense, locomotion, and attachment. Nematocysts contain toxic CNIDARIAN VENOMS which are injected into the victim via a barbed tubule.
Venoms obtained from Apis mellifera (honey bee) and related species. They contain various enzymes, polypeptide toxins, and other substances, some of which are allergenic or immunogenic or both. These venoms were formerly used in rheumatism to stimulate the pituitary-adrenal system.
Poisonous animal secretions forming fluid mixtures of many different enzymes, toxins, and other substances. These substances are produced in specialized glands and secreted through specialized delivery systems (nematocysts, spines, fangs, etc.) for disabling prey or predator.
Venoms from snakes of the genus Naja (family Elapidae). They contain many specific proteins that have cytotoxic, hemolytic, neurotoxic, and other properties. Like other elapid venoms, they are rich in enzymes. They include cobramines and cobralysins.
Venoms from SNAKES of the viperid family. They tend to be less toxic than elapid or hydrophid venoms and act mainly on the vascular system, interfering with coagulation and capillary membrane integrity and are highly cytotoxic. They contain large amounts of several enzymes, other factors, and some toxins.
Venoms produced by the wasp (Vespid) family of stinging insects, including hornets; the venoms contain enzymes, biogenic amines, histamine releasing factors, kinins, toxic polypeptides, etc., and are similar to bee venoms.
The class of true jellyfish, in the phylum CNIDARIA. They are mostly free-swimming marine organisms that go through five stages in their life cycle and exhibit two body forms: polyp and medusa.
Venoms from snakes of the family Elapidae, including cobras, kraits, mambas, coral, tiger, and Australian snakes. The venoms contain polypeptide toxins of various kinds, cytolytic, hemolytic, and neurotoxic factors, but fewer enzymes than viper or crotalid venoms. Many of the toxins have been characterized.
Venoms of arthropods of the order Araneida of the ARACHNIDA. The venoms usually contain several protein fractions, including ENZYMES, hemolytic, neurolytic, and other TOXINS, BIOLOGICAL.
Phylum of marine colenterates characterized by eight comb rows of fused cilia on the body surface. In contrast to CNIDARIA they lack stinging cells, but they are voracious predators and possess sticky cells (colloblasts) for capturing prey. Most species are transparent and many exhibit bioluminescence.
A class in the phylum CNIDARIA, comprised mostly of corals and anemones. All members occur only as polyps; the medusa stage is completely absent.
Venoms from animals of the order Scorpionida of the class Arachnida. They contain neuro- and hemotoxins, enzymes, and various other factors that may release acetylcholine and catecholamines from nerve endings. Of the several protein toxins that have been characterized, most are immunogenic.
Venoms from animals of the phylum Arthropoda. Those most investigated are from scorpions and spiders of the class Arachnidae and from ant, bee, and wasp families of the Insecta order Hymenoptera. The venoms contain protein toxins, enzymes, and other bioactive substances and may be lethal to man.
Flagellate EUKARYOTES, found mainly in the oceans. They are characterized by the presence of transverse and longitudinal flagella which propel the organisms in a rotating manner through the water. Dinoflagellida were formerly members of the class Phytomastigophorea under the old five kingdom paradigm.
A phylum of primitive invertebrate animals that exemplify a simple body organization. Trichoplax adhaerens is considered a key species for early metazoan evolution.
The class of box jellyfish, in the phylum CNIDARIA, characterized by their cube shape, and considered the most venomous jellyfish.
The relationships of groups of organisms as reflected by their genetic makeup.
Single-celled, aquatic endoparasitic worms that are currently considered belonging to the phylum CNIDARIA. They have a complex life cycle and parasitize a wide range of hosts including FISHES; ANNELIDA; and BRYOZOA.
A genus of poisonous snakes of the VIPERIDAE family. About 50 species are known and all are found in tropical America and southern South America. Bothrops atrox is the fer-de-lance and B. jararaca is the jararaca. (Goin, Goin, and Zug, Introduction to Herpetology, 3d ed, p336)
Antisera used to counteract poisoning by animal VENOMS, especially SNAKE VENOMS.
Animals that have no spinal column.
Venoms produced by FISHES, including SHARKS and sting rays, usually delivered by spines. They contain various substances, including very labile toxins that affect the HEART specifically and all MUSCLES generally.
The phylum of sponges which are sessile, suspension-feeding, multicellular animals that utilize flagellated cells called choanocytes to circulate water. Most are hermaphroditic. They are probably an early evolutionary side branch that gave rise to no other group of animals. Except for about 150 freshwater species, sponges are marine animals. They are a source of ALKALOIDS; STEROLS; and other complex molecules useful in medicine and biological research.
Venoms from the superfamily Formicoidea, Ants. They may contain protein factors and toxins, histamine, enzymes, and alkaloids and are often allergenic or immunogenic.
The process of cumulative change at the level of DNA; RNA; and PROTEINS, over successive generations.
The relationship between two different species of organisms that are interdependent; each gains benefits from the other or a relationship between different species where both of the organisms in question benefit from the presence of the other.
A family of extremely venomous snakes, comprising coral snakes, cobras, mambas, kraits, and sea snakes. They are widely distributed, being found in the southern United States, South America, Africa, southern Asia, Australia, and the Pacific Islands. The elapids include three subfamilies: Elapinae, Hydrophiinae, and Lauticaudinae. Like the viperids, they have venom fangs in the front part of the upper jaw. The mambas of Africa are the most dangerous of all snakes by virtue of their size, speed, and highly toxic venom. (Goin, Goin, and Zug, Introduction to Herpetology, 3d ed, p329-33)
Venoms from mollusks, including CONUS and OCTOPUS species. The venoms contain proteins, enzymes, choline derivatives, slow-reacting substances, and several characterized polypeptide toxins that affect the nervous system. Mollusk venoms include cephalotoxin, venerupin, maculotoxin, surugatoxin, conotoxins, and murexine.
"Bites and stings refer to tissue damage or toxic reactions caused by the teeth, mouthparts, or venomous secretions of animals such as insects, spiders, snakes, and mammals during predatory or defensive attacks."
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Limbless REPTILES of the suborder Serpentes.
The continuous sequence of changes undergone by living organisms during the post-embryonic developmental process, such as metamorphosis in insects and amphibians. This includes the developmental stages of apicomplexans such as the malarial parasite, PLASMODIUM FALCIPARUM.
The process of cumulative change over successive generations through which organisms acquire their distinguishing morphological and physiological characteristics.
Arthropods of the order Scorpiones, of which 1500 to 2000 species have been described. The most common live in tropical or subtropical areas. They are nocturnal and feed principally on insects and other arthropods. They are large arachnids but do not attack man spontaneously. They have a venomous sting. Their medical significance varies considerably and is dependent on their habits and venom potency rather than on their size. At most, the sting is equivalent to that of a hornet but certain species possess a highly toxic venom potentially fatal to humans. (From Dorland, 27th ed; Smith, Insects and Other Arthropods of Medical Importance, 1973, p417; Barnes, Invertebrate Zoology, 5th ed, p503)
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
A genus of venomous snakes of the subfamily Crotalinae. Twelve species of this genus are found in North and Central America and Asia. Agkistrodon contortrix is the copperhead, A. piscivorus, the cottonmouth. The former is named for its russet or orange-brown color, the latter for the white interior of its mouth. (Goin, Goin, and Zug, Introduction to Herpetology, 3d ed, p336; Moore, Poisonous Snakes of the World, 1980, p75)
Venoms produced by frogs, toads, salamanders, etc. The venom glands are usually on the skin of the back and contain cardiotoxic glycosides, cholinolytics, and a number of other bioactive materials, many of which have been characterized. The venoms have been used as arrow poisons and include bufogenin, bufotoxin, bufagin, bufotalin, histrionicotoxins, and pumiliotoxin.
Organs and other anatomical structures of non-human vertebrate and invertebrate animals.
The developmental entity of a fertilized egg (ZYGOTE) in animal species other than MAMMALS. For chickens, use CHICK EMBRYO.
Profound physical changes during maturation of living organisms from the immature forms to the adult forms, such as from TADPOLES to frogs; caterpillars to BUTTERFLIES.
A phylum of metazoan invertebrates comprising the segmented worms, and including marine annelids (POLYCHAETA), freshwater annelids, earthworms (OLIGOCHAETA), and LEECHES. Only the leeches are of medical interest. (Dorland, 27th ed)
The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.
Genes that encode highly conserved TRANSCRIPTION FACTORS that control positional identity of cells (BODY PATTERNING) and MORPHOGENESIS throughout development. Their sequences contain a 180 nucleotide sequence designated the homeobox, so called because mutations of these genes often results in homeotic transformations, in which one body structure replaces another. The proteins encoded by homeobox genes are called HOMEODOMAIN PROTEINS.
The processes occurring in early development that direct morphogenesis. They specify the body plan ensuring that cells will proceed to differentiate, grow, and diversify in size and shape at the correct relative positions. Included are axial patterning, segmentation, compartment specification, limb position, organ boundary patterning, blood vessel patterning, etc.
Synthetic analogs of NUCLEIC ACIDS composed of morpholine ring derivatives (MORPHOLINES) linked by phosphorodimidates. One standard DNA nucleic acid base (ADENINE; GUANINE; CYTOSINE; OR THYMINE) is bound to each morpholine ring.
A process of complicated morphogenetic cell movements that reorganizes a bilayer embryo into one with three GERM LAYERS and specific orientation (dorsal/ventral; anterior/posterior). Gastrulation describes the germ layer development of a non-mammalian BLASTULA or that of a mammalian BLASTOCYST.
Bites by snakes. Bite by a venomous snake is characterized by stinging pain at the wound puncture. The venom injected at the site of the bite is capable of producing a deleterious effect on the blood or on the nervous system. (Webster's 3d ed; from Dorland, 27th ed, at snake, venomous)
Photosensitive proteins in the membranes of PHOTORECEPTOR CELLS such as the rods and the cones. Opsins have varied light absorption properties and are members of the G-PROTEIN-COUPLED RECEPTORS family. Their ligands are VITAMIN A-based chromophores.
A genus of cone-shaped marine snails in the family Conidae, class GASTROPODA. It comprises more than 600 species, many containing unique venoms (CONUS VENOMS) with which they immobilize their prey.
A genus of snakes of the family VIPERIDAE. About 30 species are currently recognized, found in southeast Asia and adjacent island chains. The Okinawa habu frequently enters dwellings in search of rats and mice; the Chinese habu is often found in suburban and agricultural areas. They are quite irritable. (Moore: Poisonous Snakes of the World, 1980, p136)
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism.
Remains, impressions, or traces of animals or plants of past geological times which have been preserved in the earth's crust.
The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.
A portion of the animal phylum Chordata comprised of the subphyla CEPHALOCHORDATA; UROCHORDATA, and HYPEROTRETI, but not including the Vertebrata (VERTEBRATES). It includes nonvertebrate animals having a NOTOCHORD during some developmental stage.
Toxic substances from microorganisms, plants or animals that interfere with the functions of the nervous system. Most venoms contain neurotoxic substances. Myotoxins are included in this concept.
One of the three domains of life (the others being BACTERIA and ARCHAEA), also called Eukarya. These are organisms whose cells are enclosed in membranes and possess a nucleus. They comprise almost all multicellular and many unicellular organisms, and are traditionally divided into groups (sometimes called kingdoms) including ANIMALS; PLANTS; FUNGI; and various algae and other taxa that were previously part of the old kingdom Protista.
The internal fragments of precursor proteins (INternal proTEINS) that are autocatalytically removed by PROTEIN SPLICING. The flanking fragments (EXTEINS) are ligated forming mature proteins. The nucleic acid sequences coding for inteins are considered to be MOBILE GENETIC ELEMENTS. Inteins are composed of self-splicing domains and an endonuclease domain which plays a role in the spread of the intein's genomic sequence. Mini-inteins are composed of the self-splicing domains only.
Phospholipases that hydrolyze the acyl group attached to the 2-position of PHOSPHOGLYCERIDES.
A genus of poisonous snakes of the subfamily Elapinae of the family ELAPIDAE. They comprise the kraits. Twelve species are recognized and all inhabit southeast Asia. They are considered extremely dangerous. (Moore: Poisonous Snakes of the World, 1980, p120)
Partial cDNA (DNA, COMPLEMENTARY) sequences that are unique to the cDNAs from which they were derived.
A specific complex of toxic proteins from the venom of Crotalus durissus terrificus (South American rattlesnake). It can be separated into a phospholipase A and crotapotin fragment; the latter consists of three different amino acid chains, potentiates the enzyme, and is specifically neurotoxic.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
A technique that localizes specific nucleic acid sequences within intact chromosomes, eukaryotic cells, or bacterial cells through the use of specific nucleic acid-labeled probes.
Bites and stings inflicted by insects.
Wormlike or grublike stage, following the egg in the life cycle of insects, worms, and other metamorphosing animals.
The genetic complement of MITOCHONDRIA as represented in their DNA.
A genus of snakes of the family VIPERIDAE. It is distributed in West Pakistan, most of India, Burma, Ceylon, Thailand, southeast China, Taiwan, and a few islands of Indonesia. It hisses loudly when disturbed and strikes with great force and speed. Very prolific, it gives birth to 20-60 young. This viper is the leading cause of snakebite in India and Burma. (Moore: Poisonous Snakes of the World, 1980, p127)
Single-stranded complementary DNA synthesized from an RNA template by the action of RNA-dependent DNA polymerase. cDNA (i.e., complementary DNA, not circular DNA, not C-DNA) is used in a variety of molecular cloning experiments as well as serving as a specific hybridization probe.
The genetic complement of an organism, including all of its GENES, as represented in its DNA, or in some cases, its RNA.

Cellular and ionic basis for T-wave alternans under long-QT conditions. (1/271)

BACKGROUND: T-wave alternans (TWA), an ECG phenomenon characterized by beat-to-beat alternation of the morphology, amplitude, and/or polarity of the T wave, is commonly observed in the acquired and congenital long-QT syndromes (LQTS). This study examines the cellular and ionic basis for TWA induced by rapid pacing under conditions mimicking the LQT3 form of the congenital LQTS in an arterially perfused canine left ventricular wedge preparation. METHODS AND RESULTS: Transmembrane action potentials from epicardial, M, and endocardial cells and 6 to 8 intramural unipolar electrograms were simultaneously recorded together with a transmural ECG and isometric tension development. In the presence of sea anemone toxin (ATX-II; 20 nmol/L), an increase in pacing rate (from a cycle length [CL] of 500 to 400 to 250 ms) produced a wide spectrum of T-wave and mechanical alternans. Acceleration to CLs of 400 to 300 ms produced mild to moderate TWA principally due to beat-to-beat alternation of repolarization of cells in the M region. Transmural dispersion of repolarization during alternans was exaggerated during alternate beats. Acceleration to CLs of 300 to 250 ms caused more pronounced beat-to-beat alternation of action potential duration (APD) of the M cell, resulting in a reversal of repolarization sequence across the ventricular wall, leading to alternation in the polarity of the T wave. The peak of the negative T waves coincided with repolarization of the M region, whereas the end of the negative T wave coincided with the repolarization of epicardium. In almost all cases, electrical alternans was concordant with mechanical alternans. Torsade de pointes occurred after an abrupt acceleration of CL, which was associated with marked TWA. Both ryanodine and low [Ca2+]o completely suppressed alternans of the T wave, APD, and contraction, suggesting a critical role for intracellular Ca2+ cycling in the maintenance of TWA. CONCLUSIONS: Our results suggest that TWA observed at rapid rates under long-QT conditions is largely the result of alternation of the M-cell APD, leading to exaggeration of transmural dispersion of repolarization during alternate beats, and thus the potential for development of torsade de pointes. Our data also suggest that unlike transient forms of TWA that damp out quickly and depend on electrical restitution factors, the steady-state electrical and mechanical alternans demonstrated in this study appears to be largely the result of beat-to-beat alternans of [Ca2+]i.  (+info)

ATX II, a sodium channel toxin, sensitizes skeletal muscle to halothane, caffeine, and ryanodine. (2/271)

BACKGROUND: The function or expression of subtypes of the sodium ion (Na+) channel is altered in biopsies or cultures of skeletal muscle from many persons who are susceptible to malignant hyperthermia (MH). ATX II, a specific Na+ channel toxin from a sea anemone, causes delayed inactivation of the channel similar to that seen in cell cultures of MH muscle. ATX II was added to skeletal muscle to determine whether altered Na+ channel function could increase the sensitivity of normal skeletal muscle to agents (halothane, caffeine, ryanodine) to which MH muscle is hypersensitive. METHODS: Studies were performed of fiber bundles from the vastus lateralis muscle of persons who were deemed not MH susceptible (MH-) or MH susceptible (MH+) according to the MH diagnostic test and of strips of diaphragm muscle from rats. Preparations in a tissue bath containing Krebs solution were connected to a force transducer. ATX II was introduced 5 min before halothane, caffeine, or ryanodine. RESULTS: ATX II increased the magnitude of contracture to halothane in preparations from most MH-, but not MH+, human participants. After ATX II treatment, preparations from 9 of 24 MH- participants generated contractures to halothane, 3%, that were of the same magnitude as those from MH+ participants. Preparations from four of six ATX II-treated healthy participants also gave responses of the same magnitude as those of MH-susceptible participants to a graded halothane challenge (0.5-3%). The contractures to bolus doses of halothane in specimens from male participants were more than three times larger than the contractures in specimens from female participants. In rat muscle, ATX II increased the magnitude of contracture to caffeine (2 mM) and decreased the time to produce a 1-g contracture to ryanodine (1 microM). CONCLUSIONS: ATX II, which causes delayed inactivation of the Na+ channel in cell cultures similar to that reported in cultures of MH+ skeletal muscle, increased the sensitivity of normal muscle to three agents to which MH+ muscle is hypersensitive. The increased sensitivity to halothane, 3%, occurred in most (79%), but not all, MH- participants, and this effect was most evident in male participants. Therefore, abnormal function of the Na+ channel, even if it is a secondary event in MH, may contribute to a positive contracture test result for MH.  (+info)

Structural conservation of the pores of calcium-activated and voltage-gated potassium channels determined by a sea anemone toxin. (3/271)

The structurally defined sea anemone peptide toxins ShK and BgK potently block the intermediate conductance, Ca(2+)-activated potassium channel IKCa1, a well recognized therapeutic target present in erythrocytes, human T-lymphocytes, and the colon. The well characterized voltage-gated Kv1.3 channel in human T-lymphocytes is also blocked by both peptides, although ShK has a approximately 1,000-fold greater affinity for Kv1.3 than IKCa1. To gain insight into the architecture of the toxin receptor in IKCa1, we used alanine-scanning in combination with mutant cycle analyses to map the ShK-IKCa1 interface, and compared it with the ShK-Kv1.3 interaction surface. ShK uses the same five core residues, all clustered around the critical Lys(22), to interact with IKCa1 and Kv1.3, although it relies on a larger number of contacts to stabilize its weaker interactions with IKCa1 than with Kv1.3. The toxin binds to IKCa1 in a region corresponding to the external vestibule of Kv1.3, and the turret and outer pore of the structurally defined bacterial potassium channel, KcsA. Based on the NMR structure of ShK, we deduce the toxin receptor in IKCa1 to have x-y dimensions of approximately 22 A, a diameter of approximately 31 A, and a depth of approximately 8 A; we estimate that the ion selectivity lies approximately 13 A below the outer lip of the toxin receptor. These dimensions are in good agreement with those of the KcsA channel determined from its crystal structure, and the inferred structure of Kv1.3 based on mapping with scorpion toxins. Thus, these distantly related channels exhibit architectural similarities in the outer pore region. This information could facilitate development of specific and potent modulators of the therapeutically important IKCa1 channel.  (+info)

Cysteine-scanning mutagenesis of an eukaryotic pore-forming toxin from sea anemone: topology in lipid membranes. (4/271)

Equinatoxin II is a cysteineless pore-forming protein from the sea anemone Actinia equina. It readily creates pores in membranes containing sphingomyelin. Its topology when bound in lipid membranes has been studied using cysteine-scanning mutagenesis. At approximately every tenth residue, a cysteine was introduced. Nineteen single cysteine mutants were produced in Escherichia coli and purified. The accessibility of the thiol groups in lipid-embedded cysteine mutants was studied by reaction with biotin maleimide. Most of the mutants were modified, except those with cysteines at positions 105 and 114. Mutants R144C and S160C were modified only at high concentrations of the probe. Similar results were obtained if membrane-bound biotinylated mutants were tested for avidin binding, but in this case three more mutants gave a negative result: S1C, S13C and K43C. Furthermore, mutants S1C, S13C, K20C, K43C and S95C reacted with biotin only after insertion into the lipid, suggesting that they were involved in major conformational changes occurring upon membrane binding. These results were further confirmed by labeling the mutants with acrylodan, a polarity-sensitive fluorescent probe. When labeled mutants were combined with vesicles, the following mutants exhibited blue-shifts, indicating the transfer of acrylodan into a hydrophobic environment: S13C, K20C, S105C, S114C, R120C, R144C and S160C. The overall results suggest that at least two regions are embedded within the lipid membrane: the N-terminal 13-20 region, probably forming an amphiphilic helix, and the tryptophan-rich 105-120 region. Arg144, Ser160 and residues nearby could be involved in making contacts with lipid headgroups. The association with the membrane appears to be unique and different from that of bacterial pore-forming proteins and therefore equinatoxin II may serve as a model for eukaryotic channel-forming toxins.  (+info)

Increased hindrance on the chiral carbon atom of mexiletine enhances the block of rat skeletal muscle Na+ channels in a model of myotonia induced by ATX. (5/271)

1 The antiarrhythmic drug mexiletine (Mex) is also used against myotonia. Searching for a more efficient drug, a new compound (Me5) was synthesized substituting the methyl group on the chiral carbon atom of Mex by an isopropyl group. Effects of Me5 on Na+ channels were compared to those of Mex in rat skeletal muscle fibres using the cell-attached patch clamp method. 2 Me5 (10 microM) reduced the maximal sodium current (INa) by 29.7+/-4.4 % (n=6) at a frequency of stimulation of 0.3 Hz and 65.7+/-4.4 % (n=6) at 1 Hz. At same concentration (10 microM), Mex was incapable of producing any effect (n=3). Me5 also shifted the steady-state inactivation curves by -7. 9+/-0.9 mV (n=6) at 0.3 Hz and -12.2+/-1.0 mV (n=6) at 1 Hz. 3 In the presence of sea anemone toxin II (ATX; 5 microM), INa decayed more slowly and no longer to zero, providing a model of sodium channel myotonia. The effects of Me5 on peak INa were similar whatever ATX was present or not. Interestingly, Me5 did not modify the INa decay time constant nor the steady-state INa to peak INa ratio. 4 Analysis of ATX-induced late Na+ channel activity shows that Me5 did not affect mean open times and single-channel conductance, thus excluding open channel block property. 5 These results indicate that increasing hindrance on the chiral atom of Mex increases drug potency on wild-type and ATX-induced noninactivating INa and that Me5 might improve the prophylaxis of myotonia.  (+info)

Mapping the functional anatomy of BgK on Kv1.1, Kv1.2, and Kv1.3. Clues to design analogs with enhanced selectivity. (6/271)

BgK is a peptide from the sea anemone Bunodosoma granulifera, which blocks Kv1.1, Kv1.2, and Kv1.3 potassium channels. Using 25 analogs substituted at a single position by an alanine residue, we performed the complete mapping of the BgK binding sites for the three Kv1 channels. These binding sites included three common residues (Ser-23, Lys-25, and Tyr-26) and a variable set of additional residues depending on the particular channel. Shortening the side chain of Lys-25 by taking out the four methylene groups dramatically decreased the BgK affinity to all Kv1 channels tested. However, the analog K25Orn displayed increased potency on Kv1.2, which makes this peptide a selective blocker for Kv1.2 (K(D) 50- and 300-fold lower than for Kv1.1 and Kv1.3, respectively). BgK analogs with enhanced selectivity could also be made by substituting residues that are differentially involved in the binding to some of the three Kv1 channels. For example, the analog F6A was found to be >500-fold more potent for Kv1.1 than for Kv1.2 and Kv1.3. These results provide new information about the mechanisms by which a channel blocker distinguishes individual channels among closely related isoforms and give clues for designing analogs with enhanced selectivity.  (+info)

Structure-function studies of tryptophan mutants of equinatoxin II, a sea anemone pore-forming protein. (7/271)

Equinatoxin II (EqtII) is a eukaryotic cytolytic toxin that avidly creates pores in natural and model lipid membranes. It contains five tryptophan residues in three different regions of the molecule. In order to study its interaction with the lipid membranes, three tryptophan mutants, EqtII Trp(45), EqtII Trp(116/117) and EqtII Trp(149), were prepared in an Escherichia coli expression system [here, the tryptophan mutants are classified according to the position of the remaining tryptophan residue(s) in each mutated protein]. They all possess a single intrinsic fluorescent centre. All mutants were less haemolytically active than the wild-type, although the mechanism of erythrocyte damage was the same. EqtII Trp(116/117) resembles the wild-type in terms of its secondary structure content, as determined from Fourier-transform infrared (FTIR) spectra and its fluorescent properties. Tryptophans at these two positions are buried within the hydrophobic interior of the protein, and are transferred to the lipid phase during the interaction with the lipid membrane. The secondary structure of the other two mutants, EqtII Trp(45) and EqtII Trp(149), was altered to a certain extent. EqtII Trp(149) was the most dissimilar from the wild-type, displaying a higher content of random-coil structure. It also retained the lowest number of nitrogen-bound protons after exchange with (2)H(2)O, which might indicate a reduced compactness of the molecule. Tryptophans in EqtII Trp(45) and EqtII Trp(149) were more exposed to water, and also remained as such in the membrane-bound form.  (+info)

Differential effects of beta-adrenergic agonists and antagonists in LQT1, LQT2 and LQT3 models of the long QT syndrome. (8/271)

OBJECTIVES: To define the cellular mechanisms responsible for the development of life-threatening arrhythmias in response to sympathetic activity in the congenital and acquired long QT syndromes (LCQTS). METHODS: Transmembrane action potentials (AP) from epicardial (EPI), M and endocardial (ENDO) cells and a transmural electrocardiogram were simultaneously recorded from an arterially perfused wedge of canine left ventricle. We examined the effect of beta-adrenergic agonists and antagonists on action potential duration (APD90), transmural dispersion of repolarization (TDR) and the development of Torsade de Pointes (TdP) in models of LQT1, LQT2 and LQT3 forms of LQTS. RESULTS: I(Ks) block with chromanol 293B (LQT1) homogeneously prolonged APD90 of the three cell types without increasing TDR. Addition of isoproterenol prolonged QT and APD90 of M but abbreviated that of EPI and ENDO, causing a persistent increase in TDR; Torsade de Pointes developed or could be induced only in the presence of isoproterenol. I(Kr) block with d-sotalol (LQT2) and augmentation of late I(Na) with ATX-II (LQT3) prolonged APD90 of M more than EPI and ENDO, causing increases in QT and TDR. TdP developed in the absence of isoproterenol. In LQT2 isoproterenol initially prolonged, then abbreviated, the APD90 of M but always abbreviated EPI, thus transiently increasing TDR and the incidence of TdP. In LQT3, isoproterenol always abbreviated APD90 of the three cell types, causing a persistent decrease in TDR and suppression of TdP. The arrhythmogenic as well as protective actions of isoproterenol were reversed by propranolol. CONCLUSIONS: Our data suggest that beta-adrenergic stimulation induces TdP by increasing transmural dispersion of repolarization in LQT1 and LQT2 but suppresses TdP by decreasing dispersion in LQT3. The data indicate that beta-blockers are protective in LQT1 and LQT2 but may facilitate TdP in LQT3.  (+info)

Cnidarian venoms are toxic substances produced by members of the phylum Cnidaria, which includes jellyfish, sea anemones, corals, and hydroids. These venoms are primarily contained in specialized cells called cnidocytes or nematocysts, which are found in the tentacles of these animals. When a cnidarian comes into contact with prey or a potential threat, the cnidocytes discharge, injecting the venom into the target through a hollow tubule.

Cnidarian venoms are complex mixtures of bioactive molecules, including proteins, peptides, and small organic compounds. The composition of these venoms can vary significantly between different cnidarian species, as well as between different life stages or sexes of the same species. Some cnidarian venoms primarily serve a defensive function, causing pain or other unpleasant symptoms in potential predators, while others have a more offensive role, helping to immobilize prey before consumption.

The effects of cnidarian venoms on humans can range from mild irritation and stinging sensations to severe pain, swelling, and allergic reactions. In some cases, cnidarian envenomations can lead to more serious complications, such as respiratory distress, cardiac arrhythmias, or even death, particularly in individuals with underlying health conditions or allergies to the venom.

Research on cnidarian venoms has led to important insights into the biochemistry and molecular mechanisms of pain, inflammation, and neurotoxicity, as well as the development of new therapeutic strategies for treating various medical conditions. Additionally, understanding the structure and function of cnidarian venom components has inspired the design of novel bioactive molecules with potential applications in drug discovery, pest control, and other areas of biotechnology.

Cnidaria is a phylum of aquatic animals that includes jellyfish, sea anemones, hydra, and corals. They are characterized by the presence of specialized stinging cells called cnidocytes, which they use for defense and capturing prey. Cnidarians have a simple body organization with two basic forms: polyps, which are typically cylindrical and attached to a substrate; and medusae, which are free-swimming and bell-shaped. Some species can exist in both forms during their life cycle.

Cnidarians have no true organs or organ systems, but they do have a unique tissue arrangement with two main layers: an outer epidermis and an inner gastrodermis, separated by a jelly-like mesoglea. They have a digestive cavity called the coelenteron, where they absorb nutrients after capturing and digesting prey. Cnidarians reproduce both sexually and asexually, with some species exhibiting complex life cycles involving multiple forms and reproductive strategies.

Hydrozoa is a class of predominantly marine, simple aquatic animals in the phylum Cnidaria. They are characterized by having a polyp form, which is typically colonial and sessile, and a medusa form, which is usually free-swimming and solitary. The polyp stage is often modular, with individual polyps being connected by stolons to form colonies. Hydrozoans have specialized cells called cnidocytes that contain stinging organelles called nematocysts, which they use for capturing prey and defense. Some well-known examples of hydrozoans include the Portuguese man o' war (Physalia physalis) and fire corals (Millepora spp.).

Sea Anemones are not considered a medical term, but they are rather marine biology organisms. They are a group of predatory sea animals belonging to the phylum Cnidaria, which also includes corals, jellyfish, and hydras. Sea anemones typically have a cylindrical or bell-shaped body crowned with tentacles that bear stinging cells used for capturing prey.

However, in a medical context, the term "anemone" is sometimes used to describe a type of skin lesion characterized by its resemblance to the sea anemone's shape and appearance. An anemone lesion is a rare cutaneous condition that presents as a solitary, red, or purple papule with multiple radiating fronds, often occurring on the face or neck. The lesions may be tender or pruritic (itchy) and can persist for several weeks to months.

It's important to note that sea anemones themselves do not have a direct medical relevance, but they can serve as a source of inspiration for medical terminology due to their unique morphological features.

Crotalid venoms are the toxic secretions produced by the members of the Crotalinae subfamily, also known as pit vipers. This group includes rattlesnakes, cottonmouths (or water moccasins), and copperheads, which are native to the Americas, as well as Old World vipers found in Asia and Europe, such as gaboon vipers and saw-scaled vipers.

Crotalid venoms are complex mixtures of various bioactive molecules, including enzymes, proteins, peptides, and other low molecular weight components. They typically contain a variety of pharmacologically active components, such as hemotoxic and neurotoxic agents, which can cause extensive local tissue damage, coagulopathy, cardiovascular dysfunction, and neuromuscular disorders in the victim.

The composition of crotalid venoms can vary significantly between different species and even among individual specimens within the same species. This variability is influenced by factors such as geographic location, age, sex, diet, and environmental conditions. As a result, the clinical manifestations of crotalid envenomation can be highly variable, ranging from mild local reactions to severe systemic effects that may require intensive medical treatment and supportive care.

Crotalid venoms have been the subject of extensive research in recent years due to their potential therapeutic applications. For example, certain components of crotalid venoms have shown promise as drugs for treating various medical conditions, such as cardiovascular diseases, pain, and inflammation. However, further studies are needed to fully understand the mechanisms of action of these venom components and to develop safe and effective therapies based on them.

I'm sorry for any confusion, but "Hydra" is not a term commonly used in medical definitions. Hydra is a genus of small, simple aquatic animals, belonging to the class Hydrozoa in the phylum Cnidaria. They are named after the multi-headed creature from Greek mythology due to their ability to regenerate lost body parts.

If you're looking for a medical term related to hydra, one possibility could be "Hydralazine," which is a medication used to treat high blood pressure. It works by relaxing the muscle in the walls of blood vessels, causing them to widen and the blood to flow more easily.

I hope this information is helpful! If you have any other questions or need clarification on a different topic, please let me know.

A nematocyst is a complex organelle found in cnidarians (such as jellyfish, sea anemones, and corals) that functions in defense and prey capture. It consists of a capsule containing coiled tubules filled with venom. When triggered by touch or chemical signals, the tubules rapidly discharge to penetrate and inject venom into the target. The rapid discharge and potent venom make nematocysts effective for both defense and prey capture in cnidarians.

Bee venom is a poisonous substance that a honeybee (Apis mellifera) injects into the skin of a person or animal when it stings. It's produced in the venom gland and stored in the venom sac of the bee. Bee venom is a complex mixture of proteins, peptides, and other compounds. The main active components of bee venom include melittin, apamin, and phospholipase A2.

Melittin is a toxic peptide that causes pain, redness, and swelling at the site of the sting. It also has hemolytic (red blood cell-destroying) properties. Apamin is a neurotoxin that can affect the nervous system and cause neurological symptoms in severe cases. Phospholipase A2 is an enzyme that can damage cell membranes and contribute to the inflammatory response.

Bee venom has been used in traditional medicine for centuries, particularly in China and other parts of Asia. It's believed to have anti-inflammatory, analgesic (pain-relieving), and immunomodulatory effects. Some studies suggest that bee venom may have therapeutic potential for a variety of medical conditions, including rheumatoid arthritis, multiple sclerosis, and chronic pain. However, more research is needed to confirm these findings and to determine the safety and efficacy of bee venom therapy.

It's important to note that bee stings can cause severe allergic reactions (anaphylaxis) in some people, which can be life-threatening. If you experience symptoms such as difficulty breathing, rapid heartbeat, or hives after being stung by a bee, seek medical attention immediately.

Venom is a complex mixture of toxic compounds produced by certain animals, such as snakes, spiders, scorpions, and marine creatures like cone snails and stonefish. These toxic substances are specifically designed to cause damage to the tissues or interfere with the normal physiological processes of other organisms, which can lead to harmful or even lethal effects.

Venoms typically contain a variety of components, including enzymes, peptides, proteins, and small molecules, each with specific functions that contribute to the overall toxicity of the mixture. Some of these components may cause localized damage, such as tissue necrosis or inflammation, while others can have systemic effects, impacting various organs and bodily functions.

The study of venoms, known as toxinology, has important implications for understanding the evolution of animal behavior, developing new therapeutics, and advancing medical treatments for envenomation (the process of being poisoned by venom). Additionally, venoms have been used in traditional medicine for centuries, and ongoing research continues to uncover novel compounds with potential applications in modern pharmacology.

Cobra venoms are a type of snake venom that is produced by cobras, which are members of the genus Naja in the family Elapidae. These venoms are complex mixtures of proteins and other molecules that have evolved to help the snake immobilize and digest its prey.

Cobra venoms typically contain a variety of toxic components, including neurotoxins, hemotoxins, and cytotoxins. Neurotoxins target the nervous system and can cause paralysis and respiratory failure. Hemotoxins damage blood vessels and tissues, leading to internal bleeding and organ damage. Cytotoxins destroy cells and can cause tissue necrosis.

The specific composition of cobra venoms can vary widely between different species of cobras, as well as between individual snakes of the same species. Some cobras have venoms that are primarily neurotoxic, while others have venoms that are more hemotoxic or cytotoxic. The potency and effects of cobra venoms can also be influenced by factors such as the age and size of the snake, as well as the temperature and pH of the environment.

Cobra bites can be extremely dangerous and even fatal to humans, depending on the species of cobra, the amount of venom injected, and the location of the bite. Immediate medical attention is required in the event of a cobra bite, including the administration of antivenom therapy to neutralize the effects of the venom.

"Viper venoms" refer to the toxic secretions produced by members of the Viperidae family of snakes, which include pit vipers (such as rattlesnakes, copperheads, and cottonmouths) and true vipers (like adders, vipers, and gaboon vipers). These venoms are complex mixtures of proteins, enzymes, and other bioactive molecules that can cause a wide range of symptoms in prey or predators, including local tissue damage, pain, swelling, bleeding, and potentially life-threatening systemic effects such as coagulopathy, cardiovascular shock, and respiratory failure.

The composition of viper venoms varies widely between different species and even among individuals within the same species. However, many viper venoms contain a variety of enzymes (such as phospholipases A2, metalloproteinases, and serine proteases) that can cause tissue damage and disrupt vital physiological processes in the victim. Additionally, some viper venoms contain neurotoxins that can affect the nervous system and cause paralysis or other neurological symptoms.

Understanding the composition and mechanisms of action of viper venoms is important for developing effective treatments for venomous snakebites, as well as for gaining insights into the evolution and ecology of these fascinating and diverse creatures.

Wasp venoms are complex mixtures of bioactive molecules produced by wasps (Hymenoptera: Vespidae) to defend themselves and paralyze prey. The main components include:

1. Phospholipases A2 (PLA2): Enzymes that can cause pain, inflammation, and damage to cell membranes.
2. Hyaluronidase: An enzyme that helps spread the venom by breaking down connective tissues.
3. Proteases: Enzymes that break down proteins and contribute to tissue damage and inflammation.
4. Antigen 5: A major allergen that can cause severe allergic reactions (anaphylaxis) in sensitive individuals.
5. Mastoparan: A peptide that induces histamine release, leading to localized inflammation and pain.
6. Neurotoxins: Some wasp venoms contain neurotoxins that can cause paralysis or neurological symptoms.

The composition of wasp venoms may vary among species, and individual sensitivity to the components can result in different reactions ranging from localized pain, swelling, and redness to systemic allergic responses.

Scyphozoa is a class in the phylum Cnidaria, which includes true jellyfish. Scyphozoans are free-swimming marine animals characterized by a medusa-like stage in their life cycle that is dominant and persistent. They have a bell-shaped body with tentacles hanging from the margin of the bell. The tentacles contain cnidocytes, specialized cells that deliver venom through nematocysts to capture prey. Scyphozoans have a simple nervous system and lack a brain or centralized nervous system. They also have a radial symmetry, meaning their body parts are arranged around a central axis. Some examples of Scyphozoa include the sea nettle, moon jelly, and lion's mane jellyfish.

Elapid venoms are the toxic secretions produced by elapid snakes, a family of venomous snakes that includes cobras, mambas, kraits, and coral snakes. These venoms are primarily composed of neurotoxins, which can cause paralysis and respiratory failure in prey or predators.

Elapid venoms work by targeting the nervous system, disrupting communication between the brain and muscles. This results in muscle weakness, paralysis, and eventually respiratory failure if left untreated. Some elapid venoms also contain hemotoxins, which can cause tissue damage, bleeding, and other systemic effects.

The severity of envenomation by an elapid snake depends on several factors, including the species of snake, the amount of venom injected, the location of the bite, and the size and health of the victim. Prompt medical treatment is essential in cases of elapid envenomation, as the effects of the venom can progress rapidly and lead to serious complications or death if left untreated.

Spider venoms are complex mixtures of bioactive compounds produced by the specialized glands of spiders. These venoms are primarily used for prey immobilization and defense. They contain a variety of molecules such as neurotoxins, proteases, peptides, and other biologically active substances. Different spider species have unique venom compositions, which can cause different reactions when they bite or come into contact with humans or other animals. Some spider venoms can cause mild symptoms like pain and swelling, while others can lead to more severe reactions such as tissue necrosis or even death in extreme cases.

Ctenophora, also known as comb jellies, are a phylum of marine animals characterized by the presence of cilia or combs that they use for locomotion. These creatures are typically transparent and have a gelatinous body. They are found in various sizes and shapes, ranging from a few millimeters to over a meter in length. Ctenophores do not have a true digestive system or an anus; instead, they consume their food through their mouth and excrete waste through the same opening. They primarily feed on small organisms such as plankton and other ctenophores. Some species of ctenophores are bioluminescent and produce light through a chemical reaction in their bodies.

Anthozoa is a major class of marine animals, which are exclusively aquatic and almost entirely restricted to shallow waters. They are classified within the phylum Cnidaria, which also includes corals, jellyfish, sea anemones, and hydroids. Anthozoans are characterized by their lack of medusa stage in their life cycle, as they exist solely as polyps.

This class is divided into two main subclasses: Hexacorallia (also known as Zoantharia) and Octocorallia (also known as Alcyonaria). The primary differences between these subclasses lie in the structure of their polyps and the composition of their skeletons.

1. Hexacorallia: These are commonly referred to as 'stony' or 'hard' corals, due to their calcium carbonate-based skeletons. They have a simple polyp structure with six-fold symmetry (hence the name Hexacorallia), featuring 6 tentacles around the mouth opening. Examples of Hexacorallia include reef-building corals, sea fans, and black corals.
2. Octocorallia: These are also called 'soft' corals or 'leather' corals because they lack a calcium carbonate skeleton. Instead, their supporting structures consist of proteins and other organic compounds. Octocorallia polyps exhibit eight-fold symmetry (hence the name Octocorallia), with eight tentacles around the mouth opening. Examples of Octocorallia include sea fans, sea whips, and blue corals.

Anthozoa species are primarily found in tropical and subtropical oceans, but some can be found in colder, deeper waters as well. They play a crucial role in marine ecosystems by providing habitats and shelter for various other marine organisms, particularly on coral reefs. Additionally, they contribute to the formation of limestone deposits through their calcium carbonate-based skeletons.

Scorpion venoms are complex mixtures of neurotoxins, enzymes, and other bioactive molecules that are produced by the venom glands of scorpions. These venoms are primarily used for prey immobilization and defense. The neurotoxins found in scorpion venoms can cause a variety of symptoms in humans, including pain, swelling, numbness, and in severe cases, respiratory failure and death.

Scorpion venoms are being studied for their potential medical applications, such as in the development of new pain medications and insecticides. Additionally, some components of scorpion venom have been found to have antimicrobial properties and may be useful in the development of new antibiotics.

Arthropod venoms are toxic secretions produced by the venom glands of various arthropods, such as spiders, scorpions, insects, and marine invertebrates. These venoms typically contain a complex mixture of bioactive molecules, including peptides, proteins, enzymes, and small molecules, which can cause a range of symptoms and effects in humans and other animals.

The specific composition of arthropod venoms varies widely depending on the species and can be tailored to serve various functions, such as prey immobilization, defense, or predation. Some arthropod venoms contain neurotoxins that can disrupt nerve function and cause paralysis, while others may contain cytotoxins that damage tissues or hemotoxins that affect the blood and cardiovascular system.

Arthropod venoms have been studied for their potential therapeutic applications, as some of their bioactive components have shown promise in treating various medical conditions, including pain, inflammation, and neurological disorders. However, it is important to note that arthropod venoms can also cause severe allergic reactions and other adverse effects in susceptible individuals, making it essential to exercise caution when handling or coming into contact with venomous arthropods.

Dinoflagellida is a large group of mostly marine planktonic protists, many of which are bioluminescent. Some dinoflagellates are responsible for harmful algal blooms (HABs), also known as "red tides," which can produce toxins that affect marine life and human health.

Dinoflagellates are characterized by two flagella, or whip-like structures, that they use for movement. They have complex cell structures, including a unique structure called the nucleomorph, which is the remnant of a former endosymbiotic event where another eukaryotic cell was engulfed and became part of the dinoflagellate's cell.

Dinoflagellates are important contributors to the marine food chain, serving as both primary producers and consumers. Some species form symbiotic relationships with other marine organisms, such as corals, providing them with nutrients in exchange for protection and other benefits.

Placozoa is not a medical term, but rather a taxonomic category in biology. Placozoa is a phylum that includes only one described species, Trichoplax adhaerens, which is a simple, microscopic marine animal. It has a flat, irregularly shaped body without any distinct organs or tissue layers. Its cells are totipotent, meaning they can transform into different types of cells as needed for the organism's survival.

Placozoa has been studied in some developmental and cell biology research contexts, but it is not directly relevant to medical definitions or human health.

Cubozoa is a taxonomic class of marine animals commonly known as box jellyfish or sea wasps. These creatures are characterized by their cube-shaped medusae, which have four corners and trailing tentacles on each side. The Cubozoans are found in tropical and subtropical waters around the world. They are known for their powerful venom, which can be deadly to humans.

The term "Cubozoa" is derived from the Latin word "cubus," meaning cube, and the Greek word "zoon," meaning animal. The class is part of the phylum Cnidaria, which also includes corals, sea anemones, and other jellyfish.

It's worth noting that while some people use the term "box jellyfish" to refer specifically to Cubozoans, others may use it more broadly to include any jellyfish with a box-like shape, regardless of their taxonomic classification.

Phylogeny is the evolutionary history and relationship among biological entities, such as species or genes, based on their shared characteristics. In other words, it refers to the branching pattern of evolution that shows how various organisms have descended from a common ancestor over time. Phylogenetic analysis involves constructing a tree-like diagram called a phylogenetic tree, which depicts the inferred evolutionary relationships among organisms or genes based on molecular sequence data or other types of characters. This information is crucial for understanding the diversity and distribution of life on Earth, as well as for studying the emergence and spread of diseases.

Myxozoa is a group of microscopic, primarily freshwater, parasitic cnidarians. They have complex life cycles involving one or more intermediate hosts, such as annelids or mollusks, and a definitive host, usually a fish. The adult stage of the parasite develops in the tissues of the definitive host, while the larval stages infect the muscles, gills, or other organs of the intermediate hosts.

Myxozoans are characterized by their small size (usually less than 1 mm), simple body structure, and unique spore stage. The spores contain one or two polar capsules, which are coiled structures that release thread-like filaments to help the spores attach to host tissues.

Myxozoans can cause significant damage to their hosts, leading to diseases such as whirling disease in fish and proliferative kidney disease in salmonids. These parasites have a wide geographic distribution and are found in both wild and farmed aquatic animals.

"Bothrops" is a genus of venomous snakes commonly known as lancehead vipers, found primarily in Central and South America. The name "Bothrops" comes from the Greek words "bothros," meaning pit, and "ops," meaning face, referring to the deep pits on the sides of their heads that help them detect heat and locate prey. These snakes are known for their aggressive behavior and potent venom, which can cause severe pain, swelling, tissue damage, and potentially life-threatening systemic effects if left untreated.

The genus "Bothrops" includes over 30 species of pit vipers, many of which are considered medically important due to their ability to inflict serious envenomations in humans. Some notable examples include Bothrops asper (the terciopelo or fer-de-lance), Bothrops atrox (the common lancehead), and Bothrops jararaca (the jararaca).

If you encounter a snake of this genus, it is essential to seek medical attention immediately if bitten, as the venom can cause significant harm if not treated promptly.

Antivenins, also known as antivenoms, are medications created specifically to counteract venomous bites or stings from various creatures such as snakes, spiders, scorpions, and marine animals. They contain antibodies that bind to and neutralize the toxic proteins present in venom. Antivenins are usually made by immunizing large animals (like horses) with small amounts of venom over time, which prompts the animal's immune system to produce antibodies against the venom. The antibody-rich serum is then collected from the immunized animal and purified for use as an antivenin.

When administered to a victim who has been envenomated, antivenins work by binding to the venom molecules, preventing them from causing further damage to the body's tissues and organs. This helps minimize the severity of symptoms and can save lives in life-threatening situations. It is essential to seek immediate medical attention if bitten or stung by a venomous creature, as antivenins should be administered as soon as possible for optimal effectiveness.

I'm sorry for any confusion, but "Invertebrates" is not a medical term. It is a term used in biology to describe a vast group of animals that do not have a vertebral column or spinal cord. This includes creatures such as insects, worms, starfish, and shellfish, among many others. They are classified as invertebrates because they lack a backbone, which is a characteristic of vertebrates, or animals that include humans and other mammals, birds, reptiles, amphibians, and fish.

Fish venoms are toxic substances produced by some species of fish, primarily found in their spines, fins, or skin. These venoms are used for defense against predators and can cause painful injuries to humans who come into contact with them. The venomous fishes belong to various taxonomic groups, including catfishes (order Siluriformes), stingrays (superorder Batoidea), scorpionfishes (family Scorpaenidae), weevers (family Trachinidae), and stonefishes (family Synanceiidae).

The composition of fish venoms varies among species, but they typically contain a mixture of proteins, enzymes, and small molecules that can induce local and systemic effects. Local reactions usually involve pain, swelling, and redness at the site of the injury, while systemic symptoms may include nausea, vomiting, difficulty breathing, paralysis, or even death in severe cases.

Immediate medical attention is required for fish venom injuries to manage pain, prevent infection, and treat potential systemic effects. Treatment usually involves removing any remaining venomous spines or fragments, immersing the wound in hot water (>45°C/113°F) to denature the proteins in the venom, and administering appropriate analgesics, antibiotics, and supportive care as needed.

Porifera, also known as sponges, is a phylum of multicellular aquatic organisms characterized by having pores in their bodies. These pores allow water to circulate through the body, bringing in food and oxygen while expelling waste products. Sponges do not have true tissues or organs; instead, they are composed of specialized cells that perform specific functions. They are generally sessile (non-mobile) and live attached to rocks, coral reefs, or other underwater structures. Some species can be quite large, while others are microscopic in size. Sponges have a long fossil record dating back over 500 million years and play important roles in marine ecosystems as filter feeders and habitat providers for many other marine organisms.

Ant venoms are toxic secretions produced by various species of ants as a defense mechanism against predators and to incapacitate their prey. The composition of ant venoms varies among different species, but they typically contain a mixture of alkaloids, peptides, and proteins that can cause a range of symptoms in humans, from mild irritation and pain to severe allergic reactions.

The venom of some ant species, such as the fire ants (Solenopsis spp.), contains alkaloids that can cause painful pustules and itching, while the venom of other species, like the bulldog ants (Myrmecia spp.), contains proteins that can induce severe allergic reactions and even anaphylactic shock in sensitive individuals.

Understanding the composition and effects of ant venoms is important for developing effective treatments for ant stings and for studying their potential therapeutic applications, such as using ant venom components in pain management or as leads for new drug development.

Molecular evolution is the process of change in the DNA sequence or protein structure over time, driven by mechanisms such as mutation, genetic drift, gene flow, and natural selection. It refers to the evolutionary study of changes in DNA, RNA, and proteins, and how these changes accumulate and lead to new species and diversity of life. Molecular evolution can be used to understand the history and relationships among different organisms, as well as the functional consequences of genetic changes.

In the context of medicine and biology, symbiosis is a type of close and long-term biological interaction between two different biological organisms. Generally, one organism, called the symbiont, lives inside or on another organism, called the host. This interaction can be mutually beneficial (mutualistic), harmful to the host organism (parasitic), or have no effect on either organism (commensal).

Examples of mutualistic symbiotic relationships in humans include the bacteria that live in our gut and help us digest food, as well as the algae that live inside corals and provide them with nutrients. Parasitic symbioses, on the other hand, involve organisms like viruses or parasitic worms that live inside a host and cause harm to it.

It's worth noting that while the term "symbiosis" is often used in popular culture to refer to any close relationship between two organisms, in scientific contexts it has a more specific meaning related to long-term biological interactions.

Elapidae is a family of venomous snakes, also known as elapids. This family includes many well-known species such as cobras, mambas, death adders, and sea snakes. Elapids are characterized by their fixed fangs, which are located at the front of the upper jaw and deliver venom through a hollow canal. The venom of these snakes is typically neurotoxic, causing paralysis and respiratory failure in prey or attackers.

Elapids are found throughout the world, with the greatest diversity occurring in tropical regions. They vary widely in size, from small species like the death adders that measure only a few inches long, to large species like the king cobra, which can reach lengths of up to 18 feet (5.5 meters).

Elapids are generally shy and avoid confrontations with humans whenever possible. However, they will defend themselves aggressively if threatened or cornered. Bites from elapid snakes can be medically significant and may require antivenom treatment.

Mollusk venoms are toxic substances produced by certain species of mollusks, a group of marine animals that includes snails, slugs, clams, octopuses, and squids. These venoms are primarily used for defense against predators or for hunting prey. They can contain a variety of bioactive molecules, such as proteins, peptides, and neurotoxins, which can cause a range of effects on the victim's body, from mild irritation to paralysis and death.

One well-known example of a mollusk venom is that of the cone snail, which uses its venom to capture prey. The venom of some cone snails contains compounds called conotoxins, which are highly selective for specific ion channels in the nervous system and can cause paralysis or death in their victims. These conotoxins have been studied for their potential therapeutic applications, such as pain relief and treatment for neurological disorders.

It's important to note that while some mollusk venoms can be dangerous or even deadly to humans, most species of mollusks are not harmful to people. However, it's always a good idea to exercise caution when handling any marine animals, as even non-venomous species can cause injury with their sharp shells or other structures.

"Bites and stings" is a general term used to describe injuries resulting from the teeth or venomous secretions of animals. These can include:

1. Insect bites: The bite marks are usually small, punctate, and may be accompanied by symptoms such as redness, swelling, itching, and pain. Examples include mosquito, flea, bedbug, and tick bites.

2. Spider bites: Some spiders possess venomous fangs that can cause localized pain, redness, and swelling. In severe cases, systemic symptoms like muscle cramps, nausea, vomiting, and difficulty breathing may occur. The black widow and brown recluse spiders are notorious for their venomous bites.

3. Snake bites: Venomous snakes deliver toxic saliva through their fangs, which can lead to local tissue damage, swelling, pain, and potentially life-threatening systemic effects such as paralysis, bleeding disorders, and respiratory failure.

4. Mammal bites: Animal bites from mammals like dogs, cats, and wild animals can cause puncture wounds, lacerations, and crush injuries. They may also transmit infectious diseases, such as rabies.

5. Marine animal stings: Stings from jellyfish, sea urchins, stingrays, and other marine creatures can result in localized pain, redness, swelling, and systemic symptoms like difficulty breathing, muscle cramps, and altered heart rhythms. Some marine animals' venoms can cause severe allergic reactions or even death.

Treatment for bites and stings varies depending on the type and severity of the injury. It may include wound care, pain management, antibiotics to prevent infection, and in some cases, antivenom therapy to counteract the effects of venom. Seeking immediate medical attention is crucial in severe cases or when systemic symptoms are present.

Molecular sequence data refers to the specific arrangement of molecules, most commonly nucleotides in DNA or RNA, or amino acids in proteins, that make up a biological macromolecule. This data is generated through laboratory techniques such as sequencing, and provides information about the exact order of the constituent molecules. This data is crucial in various fields of biology, including genetics, evolution, and molecular biology, allowing for comparisons between different organisms, identification of genetic variations, and studies of gene function and regulation.

I'm sorry for any confusion, but "snakes" is not a medical term. It refers to a group of legless reptiles that can be found on every continent except Antarctica. If you have any questions about snakes in a different context, please provide more information and I'll do my best to help!

'Life cycle stages' is a term used in the context of public health and medicine to describe the different stages that an organism goes through during its lifetime. This concept is particularly important in the field of epidemiology, where understanding the life cycle stages of infectious agents (such as bacteria, viruses, parasites) can help inform strategies for disease prevention and control.

The life cycle stages of an infectious agent may include various forms such as spores, cysts, trophozoites, schizonts, or vectors, among others, depending on the specific organism. Each stage may have different characteristics, such as resistance to environmental factors, susceptibility to drugs, and ability to transmit infection.

For example, the life cycle stages of the malaria parasite include sporozoites (the infective form transmitted by mosquitoes), merozoites (the form that infects red blood cells), trophozoites (the feeding stage inside red blood cells), schizonts (the replicating stage inside red blood cells), and gametocytes (the sexual stage that can be taken up by mosquitoes to continue the life cycle).

Understanding the life cycle stages of an infectious agent is critical for developing effective interventions, such as vaccines, drugs, or other control measures. For example, targeting a specific life cycle stage with a drug may prevent transmission or reduce the severity of disease. Similarly, designing a vaccine to elicit immunity against a particular life cycle stage may provide protection against infection or disease.

Biological evolution is the change in the genetic composition of populations of organisms over time, from one generation to the next. It is a process that results in descendants differing genetically from their ancestors. Biological evolution can be driven by several mechanisms, including natural selection, genetic drift, gene flow, and mutation. These processes can lead to changes in the frequency of alleles (variants of a gene) within populations, resulting in the development of new species and the extinction of others over long periods of time. Biological evolution provides a unifying explanation for the diversity of life on Earth and is supported by extensive evidence from many different fields of science, including genetics, paleontology, comparative anatomy, and biogeography.

I believe there may be some confusion in your question as "scorpions" are not a medical term, but instead refer to a type of arachnid. If you're asking about a medical condition that might involve scorpions, then perhaps you're referring to "scorpion stings."

Scorpion stings occur when a scorpion uses its venomous stinger to inject venom into another animal or human. The effects of a scorpion sting can vary greatly depending on the species of scorpion and the amount of venom injected, but generally, they can cause localized pain, swelling, and redness at the site of the sting. In more severe cases, symptoms such as numbness, difficulty breathing, muscle twitching, or convulsions may occur. Some species of scorpions have venom that can be life-threatening to humans, especially in children, the elderly, and those with compromised immune systems.

If you are looking for information on a specific medical condition or term, please provide more details so I can give you a more accurate answer.

An amino acid sequence is the specific order of amino acids in a protein or peptide molecule, formed by the linking of the amino group (-NH2) of one amino acid to the carboxyl group (-COOH) of another amino acid through a peptide bond. The sequence is determined by the genetic code and is unique to each type of protein or peptide. It plays a crucial role in determining the three-dimensional structure and function of proteins.

'Agkistrodon' is a genus of venomous snakes commonly known as pit vipers, found predominantly in North America and parts of Asia. This genus includes several species, among them the copperhead (A. contortrix), cottonmouth or water moccasin (A. piscivorus), and the cantil (A. bilineatus). These snakes are characterized by their triangular heads, heat-sensing pits between the eyes and nostrils, and elliptical pupils. They deliver venom through hollow fangs and can cause significant harm to humans if they bite.

It is important to note that 'Agkistrodon' species are often misidentified due to their similarities with other pit vipers. Accurate identification of a snakebite victim is crucial for proper medical treatment, so seeking professional help from herpetologists or medical professionals is highly recommended in such situations.

Amphibian venoms are toxic secretions produced by certain species of amphibians, such as frogs, toads, and salamanders. These secretions are often produced by specialized glands in the skin and can contain a variety of bioactive compounds, including alkaloids, steroids, peptides, and proteins. Some amphibian venoms can cause painful burns or irritation upon contact with the skin, while others can be deadly if ingested or introduced into the bloodstream through wounds or mucous membranes.

The study of amphibian venoms has gained increasing attention in recent years due to their potential as sources of novel bioactive compounds with therapeutic applications. For example, some peptides found in amphibian venoms have been shown to have potent analgesic, anti-inflammatory, and antimicrobial properties, making them promising candidates for the development of new drugs.

It is important to note that not all amphibians produce venom, and even those that do may use their toxic secretions primarily for defense against predators rather than for hunting prey. Additionally, while some amphibian venoms can be dangerous or even lethal to humans, most cases of envenomation occur in the context of intentional handling or accidental contact with these animals in their natural habitats.

'Animal structures' is a broad term that refers to the various physical parts and organs that make up animals. These structures can include everything from the external features, such as skin, hair, and scales, to the internal organs and systems, such as the heart, lungs, brain, and digestive system.

Animal structures are designed to perform specific functions that enable the animal to survive, grow, and reproduce. For example, the heart pumps blood throughout the body, delivering oxygen and nutrients to the cells, while the lungs facilitate gas exchange between the animal and its environment. The brain serves as the control center of the nervous system, processing sensory information and coordinating motor responses.

Animal structures can be categorized into different systems based on their function, such as the circulatory system, respiratory system, nervous system, digestive system, and reproductive system. Each system is made up of various structures that work together to perform a specific function.

Understanding animal structures and how they function is essential for understanding animal biology and behavior. It also has important implications for human health, as many animals serve as models for studying human disease and developing new treatments.

A nonmammalian embryo refers to the developing organism in animals other than mammals, from the fertilized egg (zygote) stage until hatching or birth. In nonmammalian species, the developmental stages and terminology differ from those used in mammals. The term "embryo" is generally applied to the developing organism up until a specific stage of development that is characterized by the formation of major organs and structures. After this point, the developing organism is referred to as a "larva," "juvenile," or other species-specific terminology.

The study of nonmammalian embryos has played an important role in our understanding of developmental biology and evolutionary developmental biology (evo-devo). By comparing the developmental processes across different animal groups, researchers can gain insights into the evolutionary origins and diversification of body plans and structures. Additionally, nonmammalian embryos are often used as model systems for studying basic biological processes, such as cell division, gene regulation, and pattern formation.

Biological metamorphosis is a complex process of transformation that certain organisms undergo during their development from embryo to adult. This process involves profound changes in form, function, and structure of the organism, often including modifications of various body parts, reorganization of internal organs, and changes in physiology.

In metamorphosis, a larval or juvenile form of an animal is significantly different from its adult form, both morphologically and behaviorally. This phenomenon is particularly common in insects, amphibians, and some fish and crustaceans. The most well-known examples include the transformation of a caterpillar into a butterfly or a tadpole into a frog.

The mechanisms that drive metamorphosis are regulated by hormonal signals and genetic programs. In many cases, metamorphosis is triggered by environmental factors such as temperature, moisture, or food availability, which interact with the organism's internal developmental cues to initiate the transformation. The process of metamorphosis allows these organisms to exploit different ecological niches at different stages of their lives and contributes to their evolutionary success.

Annelida is a phylum of bilaterally symmetrical, segmented animals that includes earthworms, leeches, and marine polychaetes (bristle worms). The name "Annelida" comes from the Latin word "annellus," meaning "little ring," which refers to the distinct segments found in these animals.

Each segment in annelids contains a pair of bundled nerves called the ventral nerve cord, and many also contain circular and longitudinal muscles that enable the animal to move by contracting and relaxing these muscles in a wave-like motion. Some annelids have specialized segments for functions such as reproduction or respiration.

Annelids are primarily aquatic animals, although some terrestrial species like earthworms have evolved to live on land. They vary in size from tiny marine worms that are only a few millimeters long to large marine polychaetes that can reach over a meter in length.

Annelids are important decomposers and help break down dead organic matter, returning nutrients to the soil or water. Some species of annelids are also parasitic, feeding on the blood or tissues of other animals. Overall, annelids play a crucial role in many aquatic and terrestrial ecosystems.

In genetics, sequence alignment is the process of arranging two or more DNA, RNA, or protein sequences to identify regions of similarity or homology between them. This is often done using computational methods to compare the nucleotide or amino acid sequences and identify matching patterns, which can provide insight into evolutionary relationships, functional domains, or potential genetic disorders. The alignment process typically involves adjusting gaps and mismatches in the sequences to maximize the similarity between them, resulting in an aligned sequence that can be visually represented and analyzed.

Homeobox genes are a specific class of genes that play a crucial role in the development and regulation of an organism's body plan. They encode transcription factors, which are proteins that regulate the expression of other genes. The homeobox region within these genes contains a highly conserved sequence of about 180 base pairs that encodes a DNA-binding domain called the homeodomain. This domain is responsible for recognizing and binding to specific DNA sequences, thereby controlling the transcription of target genes.

Homeobox genes are particularly important during embryonic development, where they help establish the anterior-posterior axis and regulate the development of various organs and body segments. They also play a role in maintaining adult tissue homeostasis and have been implicated in certain diseases, including cancer. Mutations in homeobox genes can lead to developmental abnormalities and congenital disorders.

Some examples of homeobox gene families include HOX genes, PAX genes, and NKX genes, among others. These genes are highly conserved across species, indicating their fundamental role in the development and regulation of body plans throughout the animal kingdom.

"Body patterning" is a general term that refers to the process of forming and organizing various tissues and structures into specific patterns during embryonic development. This complex process involves a variety of molecular mechanisms, including gene expression, cell signaling, and cell-cell interactions. It results in the creation of distinct body regions, such as the head, trunk, and limbs, as well as the organization of internal organs and systems.

In medical terminology, "body patterning" may refer to specific developmental processes or abnormalities related to embryonic development. For example, in genetic disorders such as Poland syndrome or Holt-Oram syndrome, mutations in certain genes can lead to abnormal body patterning, resulting in the absence or underdevelopment of certain muscles, bones, or other structures.

It's important to note that "body patterning" is not a formal medical term with a specific definition, but rather a general concept used in developmental biology and genetics.

Morpholinos are synthetic oligonucleotides that contain morpholine rings in their backbone instead of the ribose or deoxyribose sugars found in DNA and RNA. They are often used as antisense agents to inhibit gene expression by binding to complementary RNA sequences, preventing translation or splicing. Morpholinos are resistant to nucleases and have a neutral charge, which makes them more stable and less likely to cause off-target effects compared to other antisense technologies. They have been widely used in research to study gene function and have also shown promise as therapeutic agents for various diseases, including neuromuscular disorders and viral infections.

Gastrulation is a fundamental process in embryonic development, characterized by the transformation of a initially flat layer of cells called the blastula into a three-layered structure known as the gastrula. This complex series of cellular movements and rearrangements establishes the foundation for the formation of the three primary germ layers: the ectoderm, mesoderm, and endoderm. These germ layers further differentiate to give rise to all the diverse cell types and tissues in the developing organism, including the nervous system, muscles, bones, and internal organs.

The precise mechanisms of gastrulation vary among different animal groups; however, common features include:

1. Formation of a blastopore: A small indentation or opening that forms on the surface of the blastula, which eventually develops into the primitive gut or anus in the gastrula.
2. Invagination: The process by which cells at the blastopore fold inward and migrate towards the interior of the embryo, forming the endodermal layer.
3. Epiboly: A coordinated movement of cells that spreads over and encloses the yolk within the embryo, contributing to the formation of the ectodermal layer.
4. Delamination: The separation and migration of cells from the epiblast (the outer layer of the blastula) to form the mesodermal layer in between the ectoderm and endoderm.

Gastrulation is a critical period in embryonic development, as errors during this process can lead to severe congenital abnormalities or even embryonic lethality. A thorough understanding of gastrulation has important implications for regenerative medicine, stem cell research, and the study of evolutionary developmental biology (Evo-Devo).

A snake bite is a traumatic injury resulting from the puncture or laceration of skin by the fangs of a snake, often accompanied by envenomation. Envenomation occurs when the snake injects venom into the victim's body through its fangs. The severity and type of symptoms depend on various factors such as the species of snake, the amount of venom injected, the location of the bite, and the individual's sensitivity to the venom. Symptoms can range from localized pain, swelling, and redness to systemic effects like coagulopathy, neurotoxicity, or cardiotoxicity, which may lead to severe complications or even death if not treated promptly and appropriately.

Opsins are a type of protein that are sensitive to light and play a crucial role in vision. They are found in the photoreceptor cells of the retina, which are the specialized cells in the eye that detect light. Opsins are activated by light, which triggers a series of chemical reactions that ultimately result in the transmission of a signal to the brain, allowing us to see.

There are several different types of opsins, including rhodopsin and the cone pigments, which are found in the rods and cones of the retina, respectively. Rhodopsin is responsible for dim-light vision, while the cone pigments are involved in color vision and bright-light vision.

Opsins belong to a larger family of proteins called G protein-coupled receptors (GPCRs), which are involved in many different physiological processes in the body. In addition to their role in vision, opsins have also been found to be involved in other light-dependent processes, such as the regulation of circadian rhythms and the entrainment of the biological clock.

A Conus snail, also known as a cone snail, is a type of predatory sea snail that belongs to the family Conidae. These snails are known for their venomous harpoons, which they use to capture and immobilize prey. The venom of some species can be dangerous or even deadly to humans.

Conus snails are found in tropical and subtropical waters around the world, and there are over 700 different species. They vary in size, with some species measuring just a few millimeters long and others reaching lengths of several inches. Many Conus snails have brightly colored shells that are highly prized by collectors.

In addition to their medical significance as a source of venom, Conus snails are also of interest to researchers because they produce a variety of bioactive compounds that have potential applications in medicine. For example, some cone snail venoms contain peptides that have been shown to have pain-relieving and neuroprotective properties.

"Trimeresurus" is a genus of venomous pit vipers found primarily in Asia. Commonly known as "Asian pit vipers" or " temple pit vipers," these snakes are characterized by the presence of a heat-sensing pit organ between the eye and the nostril, which they use to detect the body heat of their prey. They are responsible for causing serious bites and occasionally fatal accidents in human beings.

It's important to note that "Trimeresurus" is a taxonomic term used in the field of biology, specifically in systematics and classification of organisms. It does not have a direct medical definition, but it refers to a group of snakes with medical significance due to their venomous nature.

Developmental gene expression regulation refers to the processes that control the activation or repression of specific genes during embryonic and fetal development. These regulatory mechanisms ensure that genes are expressed at the right time, in the right cells, and at appropriate levels to guide proper growth, differentiation, and morphogenesis of an organism.

Developmental gene expression regulation is a complex and dynamic process involving various molecular players, such as transcription factors, chromatin modifiers, non-coding RNAs, and signaling molecules. These regulators can interact with cis-regulatory elements, like enhancers and promoters, to fine-tune the spatiotemporal patterns of gene expression during development.

Dysregulation of developmental gene expression can lead to various congenital disorders and developmental abnormalities. Therefore, understanding the principles and mechanisms governing developmental gene expression regulation is crucial for uncovering the etiology of developmental diseases and devising potential therapeutic strategies.

In medical terms, "fossils" do not have a specific or direct relevance to the field. However, in a broader scientific context, fossils are the remains or impressions of prehistoric organisms preserved in petrified form or as a mold or cast in rock. They offer valuable evidence about the Earth's history and the life forms that existed on it millions of years ago.

Paleopathology is a subfield of paleontology that deals with the study of diseases in fossils, which can provide insights into the evolution of diseases and human health over time.

Sequence homology, amino acid, refers to the similarity in the order of amino acids in a protein or a portion of a protein between two or more species. This similarity can be used to infer evolutionary relationships and functional similarities between proteins. The higher the degree of sequence homology, the more likely it is that the proteins are related and have similar functions. Sequence homology can be determined through various methods such as pairwise alignment or multiple sequence alignment, which compare the sequences and calculate a score based on the number and type of matching amino acids.

Chordata is a phylum in the animal kingdom that includes animals with a notochord, dorsal hollow nerve cord, pharyngeal gill slits, and a post-anal tail at some point during their development. Nonvertebrate Chordates include two classes: Tunicata (sea squirts and salps) and Cephalochordata (lancelets). These animals do not have a backbone or vertebral column, which is why they are considered nonvertebrate. Despite the lack of a vertebral column, these animals share other common characteristics with Vertebrates, such as a circulatory system and a complex nervous system.

Neurotoxins are substances that are poisonous or destructive to nerve cells (neurons) and the nervous system. They can cause damage by destroying neurons, disrupting communication between neurons, or interfering with the normal functioning of the nervous system. Neurotoxins can be produced naturally by certain organisms, such as bacteria, plants, and animals, or they can be synthetic compounds created in a laboratory. Examples of neurotoxins include botulinum toxin (found in botulism), tetrodotoxin (found in pufferfish), and heavy metals like lead and mercury. Neurotoxic effects can range from mild symptoms such as headaches, muscle weakness, and tremors, to more severe symptoms such as paralysis, seizures, and cognitive impairment. Long-term exposure to neurotoxins can lead to chronic neurological conditions and other health problems.

Eukaryota is a domain that consists of organisms whose cells have a true nucleus and complex organelles. This domain includes animals, plants, fungi, and protists. The term "eukaryote" comes from the Greek words "eu," meaning true or good, and "karyon," meaning nut or kernel. In eukaryotic cells, the genetic material is housed within a membrane-bound nucleus, and the DNA is organized into chromosomes. This is in contrast to prokaryotic cells, which do not have a true nucleus and have their genetic material dispersed throughout the cytoplasm.

Eukaryotic cells are generally larger and more complex than prokaryotic cells. They have many different organelles, including mitochondria, chloroplasts, endoplasmic reticulum, and Golgi apparatus, that perform specific functions to support the cell's metabolism and survival. Eukaryotic cells also have a cytoskeleton made up of microtubules, actin filaments, and intermediate filaments, which provide structure and shape to the cell and allow for movement of organelles and other cellular components.

Eukaryotes are diverse and can be found in many different environments, ranging from single-celled organisms that live in water or soil to multicellular organisms that live on land or in aquatic habitats. Some eukaryotes are unicellular, meaning they consist of a single cell, while others are multicellular, meaning they consist of many cells that work together to form tissues and organs.

In summary, Eukaryota is a domain of organisms whose cells have a true nucleus and complex organelles. This domain includes animals, plants, fungi, and protists, and the eukaryotic cells are generally larger and more complex than prokaryotic cells.

An intein is a type of mobile genetic element that can be found within the proteins of various organisms, including bacteria, archaea, and eukaryotes. Inteins are intervening sequences of amino acids that are capable of self-excising from their host protein through a process called protein splicing.

Protein splicing involves the cleavage of the intein from the flanking sequences (known as exteins) and the formation of a peptide bond between the two exteins, resulting in a mature, functional protein. Inteins can also ligate themselves to form circular proteins or can be transferred horizontally between different organisms through various mechanisms.

Inteins have been identified as potential targets for drug development due to their essential role in the survival and virulence of certain pathogenic bacteria. Additionally, the protein splicing mechanism of inteins has been harnessed for various biotechnological applications, such as the production of recombinant proteins and the development of biosensors.

Phospholipase A2 (PLA2) is a type of enzyme that catalyzes the hydrolysis of the sn-2 ester bond in glycerophospholipids, releasing free fatty acids, such as arachidonic acid, and lysophospholipids. These products are important precursors for the biosynthesis of various signaling molecules, including eicosanoids, platelet-activating factor (PAF), and lipoxins, which play crucial roles in inflammation, immunity, and other cellular processes.

Phospholipases A2 are classified into several groups based on their structure, mechanism of action, and cellular localization. The secreted PLA2s (sPLA2s) are found in extracellular fluids and are characterized by a low molecular weight, while the calcium-dependent cytosolic PLA2s (cPLA2s) are larger proteins that reside within cells.

Abnormal regulation or activity of Phospholipase A2 has been implicated in various pathological conditions, such as inflammation, neurodegenerative diseases, and cancer. Therefore, understanding the biology and function of these enzymes is essential for developing novel therapeutic strategies to target these disorders.

'Bungarus' is a genus of venomous elapid snakes commonly known as kraits, which are native to South and Southeast Asia. The term 'Bungarus' comes from the natural history classification system used in biology, specifically in the field of herpetology (the study of amphibians and reptiles).

Kraits are known for their highly potent neurotoxic venom, which can cause respiratory failure and death if left untreated. They are typically nocturnal and have a distinctive pattern of alternating black, white, and yellow bands. Some of the more well-known species in this genus include the banded krait (Bungarus fasciatus) and the Malayan krait (Bungarus candidus).

It's worth noting that 'Bungarus' is not a medical term per se, but rather a taxonomic designation used by biologists to classify a group of related organisms. However, understanding the properties and behaviors of venomous snakes like kraits can be important for medical professionals who may encounter patients who have been bitten or envenomated by these creatures.

Expressed Sequence Tags (ESTs) are short, single-pass DNA sequences that are derived from cDNA libraries. They represent a quick and cost-effective method for large-scale sequencing of gene transcripts and provide an unbiased view of the genes being actively expressed in a particular tissue or developmental stage. ESTs can be used to identify and study new genes, to analyze patterns of gene expression, and to develop molecular markers for genetic mapping and genome analysis.

Crotoxin is a type of protein toxin found in the venom of the South American rattlesnake, Crotalus durissus terrificus. It is a heterodimeric presynaptic neurotoxin composed of two subunits, an acidic subunit (CA) and a basic subunit (CB), which work together to inhibit the release of neurotransmitters from nerve endings. Crotoxin has been extensively studied for its potential therapeutic applications in various medical conditions, including inflammation, pain, and cancer. However, it is also highly toxic and can cause serious harm if ingested or introduced into the body through a snake bite.

A base sequence in the context of molecular biology refers to the specific order of nucleotides in a DNA or RNA molecule. In DNA, these nucleotides are adenine (A), guanine (G), cytosine (C), and thymine (T). In RNA, uracil (U) takes the place of thymine. The base sequence contains genetic information that is transcribed into RNA and ultimately translated into proteins. It is the exact order of these bases that determines the genetic code and thus the function of the DNA or RNA molecule.

In situ hybridization (ISH) is a molecular biology technique used to detect and localize specific nucleic acid sequences, such as DNA or RNA, within cells or tissues. This technique involves the use of a labeled probe that is complementary to the target nucleic acid sequence. The probe can be labeled with various types of markers, including radioisotopes, fluorescent dyes, or enzymes.

During the ISH procedure, the labeled probe is hybridized to the target nucleic acid sequence in situ, meaning that the hybridization occurs within the intact cells or tissues. After washing away unbound probe, the location of the labeled probe can be visualized using various methods depending on the type of label used.

In situ hybridization has a wide range of applications in both research and diagnostic settings, including the detection of gene expression patterns, identification of viral infections, and diagnosis of genetic disorders.

Insect bites and stings refer to the penetration of the skin by insects, such as mosquitoes, fleas, ticks, or bees, often resulting in localized symptoms including redness, swelling, itching, and pain. The reaction can vary depending on the individual's sensitivity and the type of insect. In some cases, systemic reactions like anaphylaxis may occur, which requires immediate medical attention. Treatment typically involves relieving symptoms with topical creams, antihistamines, or in severe cases, epinephrine. Prevention measures include using insect repellent and protective clothing.

A larva is a distinct stage in the life cycle of various insects, mites, and other arthropods during which they undergo significant metamorphosis before becoming adults. In a medical context, larvae are known for their role in certain parasitic infections. Specifically, some helminth (parasitic worm) species use larval forms to infect human hosts. These invasions may lead to conditions such as cutaneous larva migrans, visceral larva migrans, or gnathostomiasis, depending on the specific parasite involved and the location of the infection within the body.

The larval stage is characterized by its markedly different morphology and behavior compared to the adult form. Larvae often have a distinct appearance, featuring unsegmented bodies, simple sense organs, and undeveloped digestive systems. They are typically adapted for a specific mode of life, such as free-living or parasitic existence, and rely on external sources of nutrition for their development.

In the context of helminth infections, larvae may be transmitted to humans through various routes, including ingestion of contaminated food or water, direct skin contact with infective stages, or transmission via an intermediate host (such as a vector). Once inside the human body, these parasitic larvae can cause tissue damage and provoke immune responses, leading to the clinical manifestations of disease.

It is essential to distinguish between the medical definition of 'larva' and its broader usage in biology and zoology. In those fields, 'larva' refers to any juvenile form that undergoes metamorphosis before reaching adulthood, regardless of whether it is parasitic or not.

A mitochondrial genome refers to the genetic material present in the mitochondria, which are small organelles found in the cytoplasm of eukaryotic cells (cells with a true nucleus). The mitochondrial genome is typically circular and contains a relatively small number of genes compared to the nuclear genome.

Mitochondrial DNA (mtDNA) encodes essential components of the electron transport chain, which is vital for cellular respiration and energy production. MtDNA also contains genes that code for some mitochondrial tRNAs and rRNAs needed for protein synthesis within the mitochondria.

In humans, the mitochondrial genome is about 16.6 kilobases in length and consists of 37 genes: 2 ribosomal RNA (rRNA) genes, 22 transfer RNA (tRNA) genes, and 13 protein-coding genes. The mitochondrial genome is inherited maternally, as sperm contribute very few or no mitochondria during fertilization. Mutations in the mitochondrial genome can lead to various genetic disorders, often affecting tissues with high energy demands, such as muscle and nerve cells.

Russell's Viper is not a medical condition or term. It is a type of venomous snake, scientifically known as Daboia russelii, found in parts of Asia. The bite of this viper can cause severe symptoms such as pain, swelling, bleeding, tissue damage, and potentially life-threatening systemic effects like kidney failure, blood clotting problems, and cardiac arrest. Medical personnel should be notified immediately in case of a snakebite, and appropriate antivenom therapy should be initiated as soon as possible to reduce the risk of complications or mortality.

Complementary DNA (cDNA) is a type of DNA that is synthesized from a single-stranded RNA molecule through the process of reverse transcription. In this process, the enzyme reverse transcriptase uses an RNA molecule as a template to synthesize a complementary DNA strand. The resulting cDNA is therefore complementary to the original RNA molecule and is a copy of its coding sequence, but it does not contain non-coding regions such as introns that are present in genomic DNA.

Complementary DNA is often used in molecular biology research to study gene expression, protein function, and other genetic phenomena. For example, cDNA can be used to create cDNA libraries, which are collections of cloned cDNA fragments that represent the expressed genes in a particular cell type or tissue. These libraries can then be screened for specific genes or gene products of interest. Additionally, cDNA can be used to produce recombinant proteins in heterologous expression systems, allowing researchers to study the structure and function of proteins that may be difficult to express or purify from their native sources.

A genome is the complete set of genetic material (DNA, or in some viruses, RNA) present in a single cell of an organism. It includes all of the genes, both coding and noncoding, as well as other regulatory elements that together determine the unique characteristics of that organism. The human genome, for example, contains approximately 3 billion base pairs and about 20,000-25,000 protein-coding genes.

The term "genome" was first coined by Hans Winkler in 1920, derived from the word "gene" and the suffix "-ome," which refers to a complete set of something. The study of genomes is known as genomics.

Understanding the genome can provide valuable insights into the genetic basis of diseases, evolution, and other biological processes. With advancements in sequencing technologies, it has become possible to determine the entire genomic sequence of many organisms, including humans, and use this information for various applications such as personalized medicine, gene therapy, and biotechnology.

Cnidarian Toxins and Venoms. 54 (8): 1071-1074. doi:10.1016/j.toxicon.2009.02.027. ISSN 0041-0101. PMID 19268681. da Silva, ... Venoms are often complex mixtures of toxins of differing types. Toxins from venom are used to treat a wide range of medical ... Snake venom may have originated with duplication of genes that had been expressed in the salivary glands of ancestors. Venom is ... Venoms cause their biological effects via the many toxins that they contain; some venoms are complex mixtures of toxins of ...
Venom from animals such as cnidarians, scorpions and spiders may be species-specific. A substance that is weakly toxic for ... This prevents the cnidarian from stinging itself although sloughed off cnidae can be induced to fire independently. Over 30 ... Other cnidarians, such as the jellyfish Cyanea capillata (the "Lion's Mane" made famous by Sherlock Holmes) or the siphonophore ... Brinkman D, Burnell J (November 2007). "Identification, cloning and sequencing of two major venom proteins from the box ...
All cnidarians lack a centralised venom system and in replace produce numerous venom tissues throughout the body, using 2 ... They are present in all cnidarians and produce highly complex venom filled organelles. The most functional and common venom ... which allows for the opportunity for the reach of the venom to extend. In general, the venom of an Enthemonae are harmless to ... The venom that is found within these tissues are a complex combination of proteins, polypeptides and other non-protein based ...
... wasp venoms MeSH D23.946.833.230 - cnidarian venoms MeSH D23.946.833.370 - fish venoms MeSH D23.946.833.590 - mollusk venoms ... cnidarian venoms MeSH D23.946.580.370 - fish venoms MeSH D23.946.580.450 - holothurin MeSH D23.946.580.565 - lyngbya toxins ... arthropod venoms MeSH D23.946.833.065.055 - ant venoms MeSH D23.946.833.065.115 - bee venoms MeSH D23.946.833.065.115.060 - ... viper venoms MeSH D23.946.833.850.960.200 - crotalid venoms MeSH D23.946.833.850.960.200.050 - ancrod MeSH D23.946.833.850. ...
UHMedNow, "Angel Yanagihara's box jellyfish venom research leads to sting treatment", March 4, 2011 PBS Nova, Venom: Nature's ... Cnidarians of the Pacific Ocean, Cnidarians of the Indian Ocean). ... the venom contained in their tentacles. Its effectiveness was demonstrated in the PBS Nova episode "Venom: Nature's Killer", ... "Molecular dissection of box jellyfish venom cytotoxicity highlights an effective venom antidote". Nature Communications. 10 (1 ...
Pelagic cnidarians (jellyfish and related species) have nematocysts on their tentacles that eject a coiled microscopic thread ... These threads penetrate the surface of their target and release a series of complicated, biologically advanced venoms. Their ...
... wasp venoms MeSH D20.888.230 - cnidarian venoms MeSH D20.888.370 - fish venoms MeSH D20.888.590 - mollusk venoms MeSH D20.888. ... arthropod venoms MeSH D20.888.065.055 - ant venoms MeSH D20.888.065.115 - bee venoms MeSH D20.888.065.115.060 - apamin MeSH ... viper venoms MeSH D20.888.850.960.200 - crotalid venoms MeSH D20.888.850.960.200.050 - ancrod MeSH D20.888.850.960.200.105 - ... snake venoms MeSH D20.888.850.325 - elapid venoms MeSH D20.888.850.325.139 - bungarotoxins MeSH D20.888.850.325.220 - cobra ...
After many tests on frogs, it was determined that A. aurita has a proteinaceous venom that causes muscle twitching by inducing ... cnidarian), Scyphozoan genera, Cnidarians of the Atlantic Ocean, Cnidarians of the Pacific Ocean, Ulmaridae). ... "Preliminary Results of the in Vivo and in Vitro Characterization of a Tentacle Venom Fraction from the Jellyfish Aurelia aurita ...
The venom is injected through the hollow filament to immobilise the prey; the tentacles then manoeuvre the prey into the ... Coral reefs are extremely diverse marine ecosystems hosting over 4,000 species of fish, massive numbers of cnidarians, molluscs ... These cells carry venom which they rapidly release in response to contact with another organism. A dormant nematocyst ... Peel, John S. (2017). "A problematic cnidarian (Cambroctoconus; Octocorallia?) from the Cambrian (Series 2-3) of Laurentia". ...
A stronger venom would also allow C. bronzie to feed on fish, while their diet is limited to smaller prey, like shrimp. More ... Cnidarians of the Pacific Ocean). ... The venom of C. bronzie may be very similar to that of Chironex ... The venom contained in C. bronzie's cnidocytes is much less potent than other cubozoans, as there has been no evidence that C. ... However, studies have shown that the venom of C. bronzie has adversely affected the cardiovascular system of anesthetized rats ...
Cnidarians, such as jellyfish, sea anemones, Hydra and coral have numerous hair-like tentacles. Cnidarians have huge numbers of ... The longer tentacles are equipped with cnidocytes whose venom paralyses and kills prey. The smaller tentacles guide food into ... Bird J (5 June 2007). "CNIDARIANS: SIMPLE ANIMALS WITH A STING!". oceanicresearch.org. Oceanic Research Group. Archived from ...
These side effects are due to venom released from the nematocyte, as venom is part of the defense mechanism of the fire coral. ... Plate-growing fire coral forms a shape similar to that of fellow cnidarian lettuce corals - erect, thin sheets, which group ... J Venom Anim Toxins Incl Trop Dis Vol. 20, Issue. 49 Moats, E. C. (1992). Fire Coral Envenomation Vol. 3. "The Fire Corals". ... Despite its mild to moderate potential for pain, the venom is nonlethal to humans. The very small nematocysts on fire corals ...
The venom contains, among other components, numerous ion channel-blocking peptides. In 1995, a group led by Olga Castaneda and ... HMP2 and PMP-1 are astacin metalloproteinases from the Cnidarian Hydra vulgaris and the jellyfish Podocoryne carnea that ... These proteins are involved in mammalian reproduction as well as in the venoms of some snakes. In both cases, the mechanism is ... Yamazaki Y, Morita T (September 2004). "Structure and function of snake venom cysteine-rich secretory proteins". Toxicon. 44 (3 ...
Leung, TCN; Qu, Z; Nong, W; Hui, JHL; Ngai, SM (21 December 2020). "Proteomic Analysis of the Venom of Jellyfishes Rhopilema ... Cnidarians of the Pacific Ocean). ... Proteomic Analysis revealed that the R. esculentum venom ...
The venom is a mix of toxins, including neurotoxins, that paralyzes the prey so the anemone can move it to the mouth for ... Unlike other cnidarians, anemones (and other anthozoans) entirely lack the free-swimming medusal stage of their life cycle; the ... As cnidarians, sea anemones are related to corals, jellyfish, tube-dwelling anemones, and Hydra. Unlike jellyfish, sea anemones ... The muscles and nerves are much simpler than those of most other animals, although more specialised than in other cnidarians, ...
Like many cnidarians, they rely on nematocysts for protection and to capture prey. They are not difficult to care for, and can ... The nematocyte venom of A. mutabilis contains at least one or more toxins with powerful cytolytic activity. However, conditions ... Like most nematocysts found in cnidarians, the nematocysts of A. mutabilis injects a tubule of venomous substances as a ... Marino, A.; Morabito, R.; La Spada, G. (March 2009). "Factors altering the haemolytic power of crude venom from Aiptasia ...
Castañeda O, Harvey AL (December 2009). "Discovery and characterization of cnidarian peptide toxins that affect neuronal ... It is purified from the venom of Bunodosoma caissarum. This toxin is derived from the sea anemone Bunodosoma caissarum of the ...
Prey of cnidarians ranges from plankton to animals several times larger than themselves. Some cnidarians are parasites, mainly ... A tough capsule, the cnida, which houses the thread, its payload and a mixture of chemicals that may include venom or adhesives ... Hence, cnidarians and ctenophores have traditionally been labelled diploblastic, along with sponges. However, both cnidarians ... Recent phylogenetic analyses support monophyly of cnidarians, as well as the position of cnidarians as the sister group of ...
Cnidarians of the Atlantic Ocean, Cnidarians of the Caribbean Sea, Animals described in 1768). ... "Therapeutic Value Of Peptides From Animal Venoms". Comprehensive Natural Products II, 2010, pp. 287-303. .William R. Kem, Benne ... 2017). Peptide therapeutics from venom: Current status and potential. Bioorganic & Medicinal Chemistry. 26. 10.1016/j.bmc. ... "Coelenteron , Cnidarian Anatomy". Encyclopedia Britannica, 2020, https://www.britannica.com/science/coelenteron ."Stichodactyla ...
In Hydra, a cnidarian, damage to the area around the mouth is fully healed within 20 minutes. Animals in several phyla, ... Injury in animals is damage to the body caused by wounding, change in pressure, heat or cold, chemical substances, venoms and ... Injuries to animals including humans can be caused by wounding, change in pressure, heat or cold, chemical substances, venoms ...
Cnidarians of the Atlantic Ocean, Cnidarians of the Indian Ocean, Cnidarians of the Pacific Ocean, Cnidarians of the Caribbean ... The stinging, venom-filled nematocysts in the tentacles of the Portuguese man o' war can paralyze small fish and other prey. ... the two basic body plans of cnidarians. Both of these body plans comprise entire individuals in non-colonial cnidarians (for ... The blanket octopus is immune to the venom of the Portuguese man o' war; young individuals have been observed to carry broken ...
Scientists have just recently figured out how the venom of the Malo maxima affects the heart. The venom causes a concentration- ... Cnidarians of Australia, Carukiidae, Animals described in 2005). ... The venom also stimulates the sensory nerve CGRP to release in ... Only two types of species have the venom to cause Irukandji syndrome, the Irukandji Jellyfish and the Box Jelly. The Box Jelly ... It appears that the venom does not activate the parasympathetic nervous system, but the sympathetic nervous system. ...
This structure is believed to carry most of the venom within the entire nematocyst. The umbrella-shaped fleshy body of C. ... Burke, William (2002). "Cnidarians and human skin". Dermatologic Therapy. 15: 18-25. doi:10.1046/j.1529-8019.2002.01508.x. ... Chiropsoides buitendijki has potent venom that can harm human skin. Several cases of human injury have been reported off the ...
Ramezanpour, Mahnaz; da Silva, Karen Burke; Sanderson, Barbara J. S. (2013). "Venom present in sea anemone (Heteractis ... Cnidarian families, Taxa named by Angelo Andres, All stub articles, Actiniaria stubs). ... the venom of Heteractis has shown potential in treatment of lung cancer. C. Collingwood first discovered Stichodactylidae back ...
Other preyed upon animals are paralysed with venom before being eaten; venom can also be used to start digesting the animal. ... 1018 molluscs and 1016 cnidarians, for a total of 1021 wild animals. It has been estimated that there are 2.25 times more wild ... 264 Paley also contended that venom is a merciful way for poisonous animals to kill the animals that they predate. The problem ...
The proteins closest in structure to the macins are a superfamily of proteins derived from scorpion venom, dubbed the scorpion ... Hydramacin-1 was first isolated from epithelial cells of the cnidarian Hydra, a small (almost-microscopic) freshwater animal ...
Being cnidarians, they do possess distinctive harpoon-like injection stinging cells, and like many scyphozoans their ... Research also shows that pouring saltwater into stings significantly increases flow of venom into body. Browne, J., 2011, ... Toxins and Venoms; also Systemic Side Effects from Eye Medications (4th ed.). Charles C Thomas Publisher. p. 870. ISBN 978-0- ...
... and throes were observed following venom injection. S. cyanea venom also contains some antibacterial activity. Human accidents ... "A report of 49 cases of cnidarian envenoming from southeastern Brazilian coastal waters". Toxicon. 40 (10): 1445-1450. ... The venom of Conus is a conotoxin, whose action occurs by blocking muscle and neural receptors. Two cases were recorded by ... Phoneutria nigriventer venom contains two fractions PhTx-1 and PhTx-2 which are potent for primates, however, the spider has ...
The amount of venom in one animal is said to be enough to kill 60 adult humans. Chironex fleckeri was named after North ... Biology and Ecology of Venomous Marine Cnidarians, Singapore: Springer, pp. 133-168, doi:10.1007/978-981-15-1603-0_5, ISBN 978- ... The venom causes cells to become porous enough to allow potassium leakage, causing hyperkalemia, which can lead to ... Wilcox, Christie (9 April 2014). "Should we stop using vinegar to treat box jelly stings? Not yet-Venom experts weigh in on ...
It is a type of "box jellyfish" that is known for producing potent venom and is known for inflicting the Irukandji syndrome. ... Cnidarians of Australia, Animals described in 1967). ... These cells are also capable of producing venom that changes ... C. barnesi feeds by stinging its prey through nematocysts and injecting venom. Once the prey is paralyzed and in captivity, ... Studies with SDS gel- electrophoresis have found that the protein composition of the venom increased as these jellyfish altered ...
Cnidarians appear to have recruited as toxins the same kinds of proteins recruited by many other venomous animals. However, ... venom, and compares the diversity and evolution of cnidarian venom to other venomous animals (e.g., snakes and arachnids). The ... Cnidarians appeared to have more diverse venoms than amphibians and fish; about the same diversity as insects, gastropods, and ... Despite being well known for their venomous sting, many cnidarian venoms have never been studied, including from entire clades ...
Cnidarian Toxins and Venoms. 54 (8): 1071-1074. doi:10.1016/j.toxicon.2009.02.027. ISSN 0041-0101. PMID 19268681. da Silva, ... Venoms are often complex mixtures of toxins of differing types. Toxins from venom are used to treat a wide range of medical ... Snake venom may have originated with duplication of genes that had been expressed in the salivary glands of ancestors. Venom is ... Venoms cause their biological effects via the many toxins that they contain; some venoms are complex mixtures of toxins of ...
What are the therapeutic uses for Australian box jellyfish venom?. Cnidarian venoms have been investigated as a potential ... Lee H, Kwon YC, Kim E. Jellyfish venom and toxins: a review. In: Gopalakrishnakone P, Haddad Jr. V, Kem WR, Tubaro A, Kim E ( ... Heat is not recommended as part of standard treatment, although it can reduce the venom lethality when maintained at over 43 C ... The venom is spread by tiny nematocysts, each containing picograms (trillionths of a gram) of proteins. ...
... snails are equipped with one or two pairs of salivary glands that discharge at the proboscis tip inactivating cnidarian venom ... This project will allow me to identify both in predators and preys untapped venom compounds with potential applications, worth ...
The Impact of Environmental Conditions on Cnidarian Venom. Editorial: J Mar Biol Oceanogr, 10.5. DOI: Maty Luna *Abstract ... The Impact of Environmental Conditions on Cnidarian Venom in Movement and Feeding, Neuronal Coordination of Motile Cilia. ...
Biochemical study of venom sea anemone Phymactis papillosa (Actiniidae). Cuya, A. & Escobar, E., Oct 2017, In: Revista Peruana ... Biochemical study of venom sea anemone Phymactis papillosa (Actiniidae). Cuya, A. & Escobar, E., 1 Oct 2017, In: Revista ... Biochemical study of Tityus kaderkai (Scorpiones: Buthidae) venom with notes on its distribution and habitat in Peru. Escobar, ... Partial purification of toxins Hl1, Hl2 and Hl3 from Hadruroides lunatus Koch, 1867 scorpion venom (Scorpionida: Vejovidae). ...
Micro and macroevolution of sea anemone venom phenotype. Smith, E. G., Surm, J. M., Macrander, J., Simhi, A., Amir, G., ... An ancient pan-cnidarian microRNA regulates stinging capsule biogenesis in Nematostella vectensis. Fridrich, A., Salinas- ...
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OHara E, Wilson D and Seymour J (2021) The influence of ecological factors on cnidarian venoms. Toxicon, 9-10. ... Kaposi K, Courtney R and Seymour J (2022) Implications of bleaching on cnidarian venom ecology. Toxicon: X, 13. ... Impacts of bleaching on the venom ecology of a tropical cnidarian (PhD , Primary Advisor/AM/Adv) ... Examining the venom ecology of the unknown juvenile stages of the Irukandji jellyfish Carukia barnesi. Indicative Funding. $ ...
3. Classification, phylogeny and distribution of poisonous and venomous sponges and cnidarians, evolutionary strategy. Stucture ... W. Bücherl, E. E. Buckley, V. Deulofeu: Venomous animals and their venoms I-III., Academic Press, 1971 ... Application of drugs, poison and venoms in the natural therapy and in the drug industry. ...
Venom samples were lyophilized and stored at -80ºC until required for assays. When needed, the lyophilized venoms were ... It is well known that, compared to other cnidarians (typically jellyfish toxins), sea anemone toxins are relatively stable (5 ... Of the three cell lines tested, A549 was the most sensitive to killing by the venoms. A431 was vulnerable to killing by venoms ... Differential susceptibilities of human lung, breast and skin cancer cell lines to killing by five sea anemone venoms ...
CME-Carbodiimide Cnicus Cnidaria Cnidarian Venoms Cnidium Co-Repressor Proteins Coagulants Coagulase Coagulation Protein ... ...
Cnidarian Venom Evolution: Nothing New Under the Sun-by David Nelsen. Cnidarians appear to have recruited as toxins the same ...
These findings might be relevant to the pharmacological characterization of cnidarian venoms and toxins on voltage-gated ... Sea anemones produce venoms characterized by a complex mixture of low molecular weight compounds, proteins and peptides acting ... In this study, we evaluated the effect of a low molecular weight fraction from the venom of the sea anemone Lebrunia neglecta ... A Sea Anemone Lebrunia neglecta Venom Fraction Decreases Boar Sperm Cells Capacitation: Possible Involvement of HVA Calcium ...
... which is consistent with previous findings in other cnidarian venoms. However, we found few toxins that are typical of sea ... We identified 525 venom-like genes between all four species. The venom-gene profile for each species was dominated by enzymatic ... both known to utilize venom in stinging-cell rich tentacles. Cnidarians are an entirely venomous group that utilize their ... Our study is the first to provide a survey of the putative venom composition of cerianthids and contributes to our general ...
Membrane Microdomains, Animals, Cattle, Humans, Sphingomyelins, Cnidarian Venoms, Surface Plasmon Resonance, Amino Acid ...
New Insights Into Cellular and Developmental Dynamics of Venom Composition and Delivery System in the Cnidarian Model ... Evolution of the Cnidarian MicroRNA Mode of Action, and the Developmental Role of the Ancient miR-2022 Prof. Y. Moran 2021 ...
This study describes the structural characterization of a totally new family of peptides from the venom of the snake green ... and Cnidarians) and 103,000 flying species (hymenopterans) have already been reported, and that each of their venoms is ... Soares, S.G., Oliveira, L.L.: Venom-Sweet-Venom: N-Linked Glycosylation in Snake Venom Toxins. Protein Pept. Lett. 16(8), 913- ... The green mamba venom was separated into 13 fractions by cation exchange chromatography over 16 h (Figure 1a). As the venom ...
Predation (Biology), Venom Description Background In cnidarians, antagonistic interactions with predators and prey are mediated ... Some like it hot : population-specific adaptations in venom production to abiotic stressors in a widely distributed cnidarian ... Decoupling behavioral and transcriptional responses to color in an eyeless cnidarian Author Reitzel, Adam M., Leach, Whitney ... Although cnidarians exhibit diel behavioral rhythms including cycles in locomotor activity, tentacle extension and spawning, ...
Cnidarian Venoms [D23.946.580.230] Cnidarian Venoms * Fish Venoms [D23.946.580.370] Fish Venoms ...
Animals use venom for defense or to subdue prey, and they deliver these toxic substances by biting or stinging. Venom often ... Certain types of cnidarian can cause life-threatening effects in humans. The Australian box jellyfish, Chironex fleckeri, can ... Hemotoxic venom interferes with blood clotting, which can cause abnormal bleeding. Myotoxic venom effects cause extensive ... The venom on their spines can cause intense burning pain, redness, and swelling of the injured areas. Rare reports of illness ...
Box jellyfish are cnidarian invertebrates distinguished by their cube-shaped medusae. Some species of box jellyfish produce ... making it explode and spray corrosive venom to the predator. ... extremely potent venom: Chironex fleckeri, Carukia barnesi and ...
Forage for more such amazing facts about Cnidarians, in this story. ... a Cnidarian invertebrate belonging to class Cubozoa, is the worlds most venomous and poisonous creature. So powerful is its ... The nematocysts present at the tips of the tentacles contain venom, which is injected into the body of the Cnidarians victim ... This causes the Cnidarians to collapse when taken out of the water.. ► In some Cnidarian species like the hydra, the mesoglea ...
An asp caterpillar has a venom that causes excruciating pain and deters predators. The venom has a surprising origin. ... Some centipedes, cnidarians and fish do as well.. Willy van Strien. Photo: asp caterpillar of southern flannel moth Megalopyge ... The venom of the Megalopygid family is unique among the Lepidoptera. Isnt it strange that caterpillars of this family make the ... But it is not a good idea to touch them, because spines are hidden under the hairs that inject a venom when touched. The result ...
Cnidarian Venoms. *Fish Venoms. *Holothurin. *Lyngbya Toxins. *Mollusk Venoms. *Saxitoxin. *Tetrodotoxin. *Purines ...
Cnidarian Venoms [D23.946.580.230] Cnidarian Venoms * Fish Venoms [D23.946.580.370] Fish Venoms ...
Jellyfish Venoms use Cnidarian Venoms Jellyfish, Box use Cubozoa Jellyfish, Moon use Scyphozoa ...
Jellyfish Venoms use Cnidarian Venoms Jellyfish, Box use Cubozoa Jellyfish, Moon use Scyphozoa ...
Jellyfish Venoms use Cnidarian Venoms Jellyfish, Box use Cubozoa Jellyfish, Moon use Scyphozoa ...
Jellyfish Venoms use Cnidarian Venoms. Jellyfish, Box use Cubozoa. Jellyfish, Moon use Scyphozoa ...

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