Ethyldimethylaminopropyl Carbodiimide: Carbodiimide cross-linking reagent.CarbodiimidesCME-CarbodiimideEducation, Medical, Continuing: Educational programs designed to inform physicians of recent advances in their field.Cross-Linking Reagents: Reagents with two reactive groups, usually at opposite ends of the molecule, that are capable of reacting with and thereby forming bridges between side chains of amino acids in proteins; the locations of naturally reactive areas within proteins can thereby be identified; may also be used for other macromolecules, like glycoproteins, nucleic acids, or other.Dicyclohexylcarbodiimide: A carbodiimide that is used as a chemical intermediate and coupling agent in peptide synthesis. (From Hawley's Condensed Chemical Dictionary, 12th ed)Succinimides: A subclass of IMIDES with the general structure of pyrrolidinedione. They are prepared by the distillation of ammonium succinate. They are sweet-tasting compounds that are used as chemical intermediates and plant growth stimulants.Ferredoxin-NADP Reductase: An enzyme that catalyzes the oxidation and reduction of FERREDOXIN or ADRENODOXIN in the presence of NADP. EC 1.18.1.2 was formerly listed as EC 1.6.7.1 and EC 1.6.99.4.Glutaral: One of the protein CROSS-LINKING REAGENTS that is used as a disinfectant for sterilization of heat-sensitive equipment and as a laboratory reagent, especially as a fixative.Kinetics: The rate dynamics in chemical or physical systems.Chemistry: A basic science concerned with the composition, structure, and properties of matter; and the reactions that occur between substances and the associated energy exchange.Chemical Phenomena: The composition, conformation, and properties of atoms and molecules, and their reaction and interaction processes.Glucan 1,4-alpha-Glucosidase: An enzyme that catalyzes the hydrolysis of terminal 1,4-linked alpha-D-glucose residues successively from non-reducing ends of polysaccharide chains with the release of beta-glucose. It is also able to hydrolyze 1,6-alpha-glucosidic bonds when the next bond in sequence is 1,4.Carboxylic Acids: Organic compounds containing the carboxy group (-COOH). This group of compounds includes amino acids and fatty acids. Carboxylic acids can be saturated, unsaturated, or aromatic.Adrenodoxin: An iron-sulfur protein which serves as an electron carrier in enzymatic steroid hydroxylation reactions in adrenal cortex mitochondria. The electron transport system which catalyzes this reaction consists of adrenodoxin reductase, NADP, adrenodoxin, and cytochrome P-450.Hydroxylamines: Organic compounds that contain the (-NH2OH) radical.Rabbits: The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.Indicators and Reagents: Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant & Hackh's Chemical Dictionary, 5th ed, p301, p499)Bromosuccinimide: A brominating agent that replaces hydrogen atoms in benzylic or allylic positions. It is used in the oxidation of secondary alcohols to ketones and in controlled low-energy brominations. (From Miall's Dictionary of Chemistry, 5th ed; Hawley's Condensed Chemical Dictionary, 12th ed,).Myosin Subfragments: Parts of the myosin molecule resulting from cleavage by proteolytic enzymes (PAPAIN; TRYPSIN; or CHYMOTRYPSIN) at well-localized regions. Study of these isolated fragments helps to delineate the functional roles of different parts of myosin. Two of the most common subfragments are myosin S-1 and myosin S-2. S-1 contains the heads of the heavy chains plus the light chains and S-2 contains part of the double-stranded, alpha-helical, heavy chain tail (myosin rod).Macular Edema: Fluid accumulation in the outer layer of the MACULA LUTEA that results from intraocular or systemic insults. It may develop in a diffuse pattern where the macula appears thickened or it may acquire the characteristic petaloid appearance referred to as cystoid macular edema. Although macular edema may be associated with various underlying conditions, it is most commonly seen following intraocular surgery, venous occlusive disease, DIABETIC RETINOPATHY, and posterior segment inflammatory disease. (From Survey of Ophthalmology 2004; 49(5) 470-90)Diethyl Pyrocarbonate: Preservative for wines, soft drinks, and fruit juices and a gentle esterifying agent.Solubility: The ability of a substance to be dissolved, i.e. to form a solution with another substance. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Hydrogen-Ion Concentration: The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Actins: Filamentous proteins that are the main constituent of the thin filaments of muscle fibers. The filaments (known also as filamentous or F-actin) can be dissociated into their globular subunits; each subunit is composed of a single polypeptide 375 amino acids long. This is known as globular or G-actin. In conjunction with MYOSINS, actin is responsible for the contraction and relaxation of muscle.Clathrin: The main structural coat protein of COATED VESICLES which play a key role in the intracellular transport between membranous organelles. Each molecule of clathrin consists of three light chains (CLATHRIN LIGHT CHAINS) and three heavy chains (CLATHRIN HEAVY CHAINS) that form a structure called a triskelion. Clathrin also interacts with cytoskeletal proteins.Value-Based Purchasing: Purchasers are provided information on the quality of health care, including patient outcomes and health status, with data on the dollar outlays going towards health. The focus is on managing the use of the health care system to reduce inappropriate care and to identify and reward the best-performing providers. (from http://www.ahrq.gov/qual/meyerrpt.htm accessed 11/25/2011)Peptide Fragments: Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.Gelatin: A product formed from skin, white connective tissue, or bone COLLAGEN. It is used as a protein food adjuvant, plasma substitute, hemostatic, suspending agent in pharmaceutical preparations, and in the manufacturing of capsules and suppositories.Ferrous Compounds: Inorganic or organic compounds that contain divalent iron.Ferredoxins: Iron-containing proteins that transfer electrons, usually at a low potential, to flavoproteins; the iron is not present as in heme. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Electrophoresis, Polyacrylamide Gel: Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.Glycine: A non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also a fast inhibitory neurotransmitter.Enzymes, Immobilized: Enzymes which are immobilized on or in a variety of water-soluble or water-insoluble matrices with little or no loss of their catalytic activity. Since they can be reused continuously, immobilized enzymes have found wide application in the industrial, medical and research fields.Chromatography, High Pressure Liquid: Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.Amino Acids: Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Specialty Boards: Organizations which certify physicians and dentists as specialists in various fields of medical and dental practice.Protein Binding: The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.Proton-Translocating ATPases: Multisubunit enzymes that reversibly synthesize ADENOSINE TRIPHOSPHATE. They are coupled to the transport of protons across a membrane.Polymers: Compounds formed by the joining of smaller, usually repeating, units linked by covalent bonds. These compounds often form large macromolecules (e.g., BIOPOLYMERS; PLASTICS).Tensile Strength: The maximum stress a material subjected to a stretching load can withstand without tearing. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed, p2001)Cattle: Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.Education, Distance: Education via communication media (correspondence, radio, television, computer networks) with little or no in-person face-to-face contact between students and teachers. (ERIC Thesaurus, 1997)Glutamates: Derivatives of GLUTAMIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain the 2-aminopentanedioic acid structure.Molecular Weight: The sum of the weight of all the atoms in a molecule.Tendons: Fibrous bands or cords of CONNECTIVE TISSUE at the ends of SKELETAL MUSCLE FIBERS that serve to attach the MUSCLES to bones and other structures.Macromolecular Substances: Compounds and molecular complexes that consist of very large numbers of atoms and are generally over 500 kDa in size. In biological systems macromolecular substances usually can be visualized using ELECTRON MICROSCOPY and are distinguished from ORGANELLES by the lack of a membrane structure.Clathrin-Coated Vesicles: Vesicles formed when cell-membrane coated pits (COATED PITS, CELL-MEMBRANE) invaginate and pinch off. The outer surface of these vesicles is covered with a lattice-like network of the protein CLATHRIN. Shortly after formation, however, the clathrin coat is removed and the vesicles are referred to as ENDOSOMES.Dynamin II: A subtype of dynamin found ubiquitously expressed in a variety of tissues.Spectrophotometry, Ultraviolet: Determination of the spectra of ultraviolet absorption by specific molecules in gases or liquids, for example Cl2, SO2, NO2, CS2, ozone, mercury vapor, and various unsaturated compounds. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Biocompatible Materials: Synthetic or natural materials, other than DRUGS, that are used to replace or repair any body TISSUES or bodily function.Osteopathic Medicine: A medical discipline that is based on the philosophy that all body systems are interrelated and dependent upon one another for good health. This philosophy, developed in 1874 by Dr. Andrew Taylor Still, recognizes the concept of "wellness" and the importance of treating illness within the context of the whole body. Special attention is placed on the MUSCULOSKELETAL SYSTEM.Materials Testing: The testing of materials and devices, especially those used for PROSTHESES AND IMPLANTS; SUTURES; TISSUE ADHESIVES; etc., for hardness, strength, durability, safety, efficacy, and biocompatibility.Adenosine Triphosphatases: A group of enzymes which catalyze the hydrolysis of ATP. The hydrolysis reaction is usually coupled with another function such as transporting Ca(2+) across a membrane. These enzymes may be dependent on Ca(2+), Mg(2+), anions, H+, or DNA.NADH, NADPH Oxidoreductases: A group of oxidoreductases that act on NADH or NADPH. In general, enzymes using NADH or NADPH to reduce a substrate are classified according to the reverse reaction, in which NAD+ or NADP+ is formally regarded as an acceptor. This subclass includes only those enzymes in which some other redox carrier is the acceptor. (Enzyme Nomenclature, 1992, p100) EC 1.6.Trypsin: A serine endopeptidase that is formed from TRYPSINOGEN in the pancreas. It is converted into its active form by ENTEROPEPTIDASE in the small intestine. It catalyzes hydrolysis of the carboxyl group of either arginine or lysine. EC 3.4.21.4.Antigen-Antibody Reactions: The processes triggered by interactions of ANTIBODIES with their ANTIGENS.Hydrolysis: The process of cleaving a chemical compound by the addition of a molecule of water.Adaptor Protein Complex 2: An adaptor protein complex primarily involved in the formation of clathrin-related endocytotic vesicles (ENDOSOMES) at the CELL MEMBRANE.Protein Conformation: The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).Electrochemistry: The study of chemical changes resulting from electrical action and electrical activity resulting from chemical changes.Surface Properties: Characteristics or attributes of the outer boundaries of objects, including molecules.Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.Escherichia coli: A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.Oligonucleotides: Polymers made up of a few (2-20) nucleotides. In molecular genetics, they refer to a short sequence synthesized to match a region where a mutation is known to occur, and then used as a probe (OLIGONUCLEOTIDE PROBES). (Dorland, 28th ed)Catalysis: The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction.Myosins: A diverse superfamily of proteins that function as translocating proteins. They share the common characteristics of being able to bind ACTINS and hydrolyze MgATP. Myosins generally consist of heavy chains which are involved in locomotion, and light chains which are involved in regulation. Within the structure of myosin heavy chain are three domains: the head, the neck and the tail. The head region of the heavy chain contains the actin binding domain and MgATPase domain which provides energy for locomotion. The neck region is involved in binding the light-chains. The tail region provides the anchoring point that maintains the position of the heavy chain. The superfamily of myosins is organized into structural classes based upon the type and arrangement of the subunits they contain.Structure-Activity Relationship: The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.Muscles: Contractile tissue that produces movement in animals.Physicians, Family: Those physicians who have completed the education requirements specified by the American Academy of Family Physicians.Computer-Assisted Instruction: A self-learning technique, usually online, involving interaction of the student with programmed instructional materials.Societies, Medical: Societies whose membership is limited to physicians.Cytochrome c Group: A group of cytochromes with covalent thioether linkages between either or both of the vinyl side chains of protoheme and the protein. (Enzyme Nomenclature, 1992, p539)Mesocolon: The fold of peritoneum by which the COLON is attached to the posterior ABDOMINAL WALL.Circular Dichroism: A change from planar to elliptic polarization when an initially plane-polarized light wave traverses an optically active medium. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Sodium-Potassium-Exchanging ATPase: An enzyme that catalyzes the active transport system of sodium and potassium ions across the cell wall. Sodium and potassium ions are closely coupled with membrane ATPase which undergoes phosphorylation and dephosphorylation, thereby providing energy for transport of these ions against concentration gradients.Conflict of Interest: A situation in which an individual might benefit personally from official or professional actions. It includes a conflict between a person's private interests and official responsibilities in a position of trust. The term is not restricted to government officials. The concept refers both to actual conflict of interest and the appearance or perception of conflict.Financial Support: The provision of monetary resources including money or capital and credit; obtaining or furnishing money or capital for a purchase or enterprise and the funds so obtained. (From Random House Unabridged Dictionary, 2d ed.)Glutamic Acid: A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.Electron Transport: The process by which ELECTRONS are transported from a reduced substrate to molecular OXYGEN. (From Bennington, Saunders Dictionary and Encyclopedia of Laboratory Medicine and Technology, 1984, p270)Endocytosis: Cellular uptake of extracellular materials within membrane-limited vacuoles or microvesicles. ENDOSOMES play a central role in endocytosis.

Importance of a 5' stem-loop for longevity of papA mRNA in Escherichia coli. (1/32)

High-level expression of the major pilus subunit (PapA) of uropathogenic strains of Escherichia coli results in part from the unusually long lifetime of the mRNA that encodes this protein. Here we report that the longevity of papA mRNA derives in large measure from the protection afforded by its 5' untranslated region. This papA RNA segment can prolong the lifetime of an otherwise short-lived mRNA to which it is fused. In vivo alkylation studies indicate that, in its natural milieu, the papA message begins with a stem-loop structure. This stem-loop is important for the stabilizing effect of the papA 5' untranslated region, as evidenced by the significant acceleration in papA mRNA decay that results from its removal.  (+info)

Neuronal BC1 RNA structure: evolutionary conversion of a tRNA(Ala) domain into an extended stem-loop structure. (2/32)

By chemical and enzymatic probing, we have analyzed the secondary structure of rodent BC1 RNA, a small brain-specific non-messenger RNA. BC1 RNA is specifically transported into dendrites of neuronal cells, where it is proposed to play a role in regulation of translation near synapses. In this study we demonstrate that the 5' domain of BC1 RNA, derived from tRNA(Ala), does not fold into the predicted canonical tRNA cloverleaf structure. We present evidence that by changing bases within the tRNA(Ala) domain during the course of evolution, an extended stem-loop structure has been created in BC1 RNA. The new structural domain might function, in part, as a putative binding site for protein(s) involved in dendritic transport of BC1 RNA within neurons. Furthermore, BC1 RNA contains, in addition to the extended stem-loop structure, an internal poly(A)-rich region that is supposedly single stranded, followed by a second smaller stem-loop structure at the 3' end of the RNA. The three distinct structural domains reflect evolutionary legacies of BC1 RNA.  (+info)

Identification of the mass-silent post-transcriptionally modified nucleoside pseudouridine in RNA by matrix-assisted laser desorption/ionization mass spectrometry. (3/32)

A new method using matrix-assisted laser desorption/ionization (MALDI) mass spectrometry for the direct analysis of the mass-silent post-transcriptionally modified nucleoside pseudouridine in nucleic acids has been developed. This method utilizes 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide to derivatize pseudouridine residues. After chemical derivatization all pseudouridine residues will contain a 252 Da 'mass tag' that allows the presence of pseudouridine to be identified using mass spectrometry. Pseudouridine residues can be identified in intact nucleic acids by obtaining a mass spectrum of the nucleic acid before and after derivatization. The mass difference (in units of 252 Da) will denote the number of pseudouridine residues present. To determine the sequence location of pseudouridine, a combination of enzymatic hydrolysis and mass spectrometric steps are used. Here, MALDI analysis of RNase T1 digestion products before and after modification are used to narrow the sequence location of pseudouridine to specific T1 fragments in the gene sequence. Further mass spectrometric monitoring of exonuclease digestion products from isolated T1 fragments is then used for exact sequence placement. This approach to pseudouridine identification is demonstrated using Escherichia coli tRNAS: This new method allows for the direct determination of pseudouridine in nucleic acids, can be used to identify modified pseudouridine residues and can be used with general modification mapping approaches to completely characterize the post-transcriptional modifications present in RNAs.  (+info)

Possible interaction sites of mRNA, tRNA, translation factors and the nascent peptide in 5S, 5.8S and 28S rRNA in in vivo assembled eukaryotic ribosomal complexes. (4/32)

We have investigated possible interaction sites for mRNA, tRNA, translation factors and the nascent peptide on 5S, 5.8S and 28S rRNA in in vivo assembled translational active mouse ribosomes by comparing the chemical footprinting patterns derived from native polysomes, salt-washed polysomes (mainly lacking translational factors) and salt-washed runoff ribosomes (lacking mRNA, tRNA and translational factors). Several ligand-induced footprints were observed in 28S rRNA while no reactivity changes were seen in 5S and 5.8S rRNA. Footprints derived from mRNA, tRNA and/or the nascent peptide chain were observed in domain I of 28S rRNA (hairpin 23), in domain II (helix 37/38 and helices 42 and 43 and in the eukaryotic expansion segment 15), in domain IV (helices 67 and 74) and in domain V (helices 94 and 96 and in the peptidyl transferase ring). Some of the protected sites were homologous to sites previously suggested to be involved in mRNA, tRNA and/or peptide binding in in vitro assembled prokaryotic complexes. Additional footprints were located in regions that have not previously been found involved in ligand binding. Part of these sites could derive from the nascent peptide in the exit channel of the ribosome.  (+info)

The brome mosaic virus RNA3 intergenic replication enhancer folds to mimic a tRNA TpsiC-stem loop and is modified in vivo. (5/32)

The genome of brome mosaic virus (BMV), a positive-strand RNA virus in the alphavirus-like superfamily, consists of three capped, messenger-sense RNAs. RNA1 and RNA2 encode viral replication proteins 1a and 2a, respectively. RNA3 encodes the 3a movement protein and the coat protein, which are essential for systemic infection in plants but dispensable for RNA3 replication in plants and yeast. A subset of the 250-base intergenic region (IGR), the replication enhancer (RE), contains all cis-acting signals necessary for a crucial, early template selection step, the 1a-dependent recruitment of RNA3 into replication. One of these signals is a motif matching the conserved box B sequence of RNA polymerase III transcripts. Using chemical modification with CMCT, kethoxal, DMS, DEPC, and lead, we probed the structure of the IGR in short, defined transcripts and in full-length RNA3 in vitro, in yeast extracts, and in whole yeast cells. Our results reveal a stable, unbranched secondary structure that is not dependent on the surrounding ORF sequences or on host factors within the cell. Functional 5' and 3' deletions that defined the minimal RE in earlier deletion studies map to the end of a common helical segment. The box B motif is presented as a hairpin loop of 7 nt closed by G:C base pairs in perfect analogy to the TpsiC-stem loop in tRNA(Asp). An adjacent U-rich internal loop, a short helix, and another pyrimidine-rich loop were significantly protected from base modifications. This same arrangement is conserved between BMV and cucumoviruses CMV, TAV, and PSV. In the BMV box B loop sequence, uridines corresponding to tRNA positions T54 and psi55 were found to be modified in yeast and plants to 5mU and pseudouridine. Together with the aminoacylated viral 3'-end, this is thus the second RNA replication signal within BMV where the virus has evolved a tRNA structural mimicry to a degree that renders it a substrate for classical tRNA modification reactions in vivo.  (+info)

Structural insights into group II intron catalysis and branch-site selection. (6/32)

Group II self-splicing introns catalyze autoexcision from precursor RNA transcripts by a mechanism strikingly similar to that of the spliceosome, an RNA-protein assembly responsible for splicing together the protein-coding parts of most eukaryotic pre-mRNAs. Splicing in both cases initiates via nucleophilic attack at the 5' splice site by the 2' OH of a conserved intron adenosine residue, creating a branched (lariat) intermediate. Here, we describe the crystal structure at 3.0 A resolution of a 70-nucleotide RNA containing the catalytically essential domains 5 and 6 of the yeast ai5gamma group II self-splicing intron, revealing an unexpected two-nucleotide bulged structure around the branch-point adenosine in domain 6.  (+info)

Structure of the 5' nontranslated region of the coxsackievirus b3 genome: Chemical modification and comparative sequence analysis. (7/32)

Coxsackievirus B3 (CVB3) is a picornavirus which causes myocarditis and pancreatitis and may play a role in type I diabetes. The viral genome is a single 7,400-nucleotide polyadenylated RNA encoding 11 proteins in a single open reading frame. The 5' end of the viral genome contains a highly structured nontranslated region (5'NTR) which folds to form an internal ribosome entry site (IRES) as well as structures responsible for genome replication, both of which are critical for virulence. A structural model of the CVB3 5'NTR, generated primarily by comparative sequence analysis and energy minimization, shows seven domains (I to VII). While this model provides a preliminary basis for structural analysis, the model lacks comprehensive experimental validation. Here we provide experimental evidence from chemical modification analysis to determine the structure of the CVB3 5'NTR. Chemical probing results show that the theoretical model for the CVB3 5'NTR is largely, but not completely, supported experimentally. In combination with our chemical probing data, we have used the RNASTRUCTURE algorithm and sequence comparison of 105 enterovirus sequences to provide evidence for novel secondary and tertiary interactions. A comprehensive examination of secondary structure is discussed, along with new evidence for tertiary interactions. These include a loop E motif in domain III and a long-range pairing interaction that links domain II to domain V. The results of our work provide mechanistic insight into key functional elements in the cloverleaf and IRES, thereby establishing a base of structural information from which to interpret experiments with CVB3 and other picornaviruses.  (+info)

Probing RNA structure with chemical reagents and enzymes. (8/32)

 (+info)

*List of MeSH codes (D02)

... cme-carbodiimide MeSH D02.491.203.385 --- dicyclohexylcarbodiimide MeSH D02.491.203.425 --- ethyl(dimethylaminopropyl) ... carbodiimide MeSH D02.491.485.100 --- azetidinecarboxylic acid MeSH D02.491.485.400 --- technetium tc 99m diethyl-iminodiacetic ...
2-Methyl-1-(2-morpholinoethyl)-3-(1-benzothiophen-3-ylcarbonyl)-1H-indole | C24H24N2O2S | CID 13645261 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
1H,1H,5H-Octafluoropentyl p-toluenesulfonate 2264-00-8 NMR spectrum, 1H,1H,5H-Octafluoropentyl p-toluenesulfonate H-NMR spectral analysis, 1H,1H,5H-Octafluoropentyl p-toluenesulfonate C-NMR spectral analysis ect.
Alfa Aesar™ 2-Chloroethyl p-toluenesulfonate, 97% 500g Alfa Aesar™ 2-Chloroethyl p-toluenesulfonate, 97% Chlorot to Chola -Organics
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Cuprate(1-), (C,C-bis((dibutylamino)sulfonyl)-29H,31H-phthalocyanine-C-sulfonato(3-)-N29,N39,N31,N32)-, ammonium CL 205925 Carbonothioic dihydrazide, N-(((3-methylphenyl)amino)thioxomethyl)-N-((1E)-1-(2-pyridinyl)ethylidene)- 3,5-Dibromo-2,4,6-trihydroxyacetophenone (o-Methoxyphenoxy)acetic acid 2-morpholinoethyl ester hydrochloride 1-Naphthacenecarboxylic acid, 2-ethyl-6,11-dihydro-5,7-dihydroxy-6,11-dioxo-, methyl ester (8CI)(9CI) (3R,5R,7R,8S,9S,10R,13R,14S,17R)-17-[(2R)-6-hydroxy-6-methyl-heptan-2-yl]-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,7-diol 5H-Benzocycloheptene-8-carboxylic acid,1-[(2R,3R)-3,4-dihydro-3,5,7- trihydroxy-2H-1-benzopyran-2-yl]-3,4,6- trihydroxy-5-oxo-,(2R,3R)-2-(3,4-dihydroxyphenyl)- 3,4-dihydro-5,7-dihydroxy-2H-1- benzopyran-3-yl ester 2-methylprop-2-enoic acid; triphenyltin 2,8-bis(phenyl-phenylsulfanyl-methyl)cyclooctan-1-one
Enzyme-based sensors have emerged as important analytical tools with application in diverse fields, and biosensors for the detection of glucose using the enzyme glucose oxidase have been widely investigated. In this work, the preparation of biosensors by electrochemical polymerization of (poly)thiophenes, namely 2,2′-bithiophene (2,2′-BT) and 4,4′-bis(2-methyl-3-butyn-2-ol)-2,2′-bithiophene (4,4′-bBT), followed by immobilization of glucose oxidase on the films, is described. N-cyclohexyl-N′-(2-morpholinoethyl)carbodiimide metho-|i|p|/i|-toluenesulfonate (CMC) was used as a condensing agent, and |i|p|/i|-benzoquinone (BQ) was used as a redox mediator in solution. The glucose oxidase electrodes with films of 2,2′-BT and 4,4′-bBT were then tested for their ability in detecting glucose from synthetic and real samples (pear, apricot, and peach fruit juices).
Morniflumate is a nonsteroidal anti-inflammatory drug (NSAID). Melica, A.; Donateo, L.; Gerardi, R.; Parenti, M. (1991). "A new anti-inflammatory-analgesic-antipyretic, morniflumate, in the treatment of chronic recurring bronchitis". Rivista europea per le scienze mediche e farmacologiche = European review for medical and pharmacological sciences = Revue europeenne pour les sciences medicales et pharmacologiques. 13 (1-2): 51-60. PMID 1796197. Civelli, M.; Vigano, T.; Acerbi, D.; Caruso, P.; Giossi, M.; Bongrani, S.; Folco, G. C. (1991). "Modulation of arachidonic acid metabolism by orally administered morniflumate in man". Agents and actions. 33 (3-4): 233-239. doi:10.1007/bf01986568. PMID 1659152. Schiantarelli, P.; Cadel, S.; Acerbi, D. (1984). "A gastroprotective anti-inflammatory agent: Theβ-morpholinoethyl ester of niflumic acid (morniflumate)". Agents and Actions. 14 (2): 247-256. doi:10.1007/BF01966649. PMID 6608862 ...
A compound of the structure ##STR1## wherein R.sup.1 and R.sup.2 are each independently, hydrogen or ##STR2## X is --(CH.sub.2).sub.m -- or --Ar--; R.sup.3 and R.sup.4 are each, independently, hydrogen, alkyl, --(CH.sub.2).sub.n --Ar, --(CH.sub.2).sub.p --NR.sup.5 R.sup.6, or --(CH.sub.2).sub.p --N.sup.+ R.sup.5 R.sup.6 R.sup.7 Y.sup.- ; R.sup.5 and R.sup.6 are each, independently, hydrogen, alkyl, or --(CH.sub.2).sub.n --Ar; Ar is an optionally substituted group selected from ##STR3## in which the optional substituents are selected from the group consisting of alkyl, aralkyl, alkoxy, cyano, halo, nitro, carbalkoxy, or perfluoroalkyl; R.sup.7 is alkyl; Y is a halide, sulfate, phosphate, or p-toluenesulfonate anion; m=1-6; n=1-6; p=1-6; with the proviso that R.sup.1 and R.sup.2 are not both hydrogen; or a pharmaceutically acceptable salt thereof, which by virtue of its immunosuppressive activity is useful in treating transplantation rejection, host vs. graft disease, autoimmune diseases and diseases of
A novel synthetic peptide corresponding to the eleven amino acid residues of the NH2 -terminal portion in the sequence of carcinoembrionic antigen (CEA) has been synthesized and this was attached by means of a water-soluble carbodiimide reagent to multichain poly(DL)-alanine as well as to bovine serum albumin. The resulting macromolecular conjugates provoked rabbit anti- CEA(1-11) peptide antibodies and a novel assay was developed for ascertaining the presence of adenocarcinomas of the digestive tract, pancreas and breast, based on said novel compositions of matter.
2-cyclohexyl-4-methyl-5-phenylmethoxypent-1-en-3-ol - chemical structural formula, chemical names, chemical properties, synthesis references
Synergistic microbicidal compositions are disclosed, comprising 4,5-dichloro-2-cyclohexyl-3-isothiazolone and one or more known microbicides for more effective, and broader control of microorganisms in various systems.
An acid protease from Aspergillus saitoi was immobilized on agarose beads of approximately 100 micrometers diameter. Solutions of gelatin were prepared in a saturated potassium bitartrate buffer and contacted with the immobilized enzyme. The Michaelis-Menten constant was determined to be 7.8 x 10-5 M at 25°C and pH of 3.5.. The maximum velocity of hydrolysis corrected for bed voidage was found to be 6.8 x 10-7 M per second under the same conditions.. ...
BioAssay record AID 874305 submitted by ChEMBL: Open TG-GATES: Regimen: Single; Time: 3 hr; Dose: Middle; Route: Gavage | Dataset: Biochemistry; Assay: GLUC (Glucose); Study_ID: 626/9.
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CAS NO:76512-92-0; Chemical name:1H-Imidazole-4-carboximidic acid, 5-amino-1-cyclohexyl-, methyl ester ; physical and chemical property of 76512-92-0, 1H-Imidazole-4-carboximidic acid, 5-amino-1-cyclohexyl-, methyl ester is provided by ChemNet.com
Comprehensive supplier list for Formamide, N-(1-cyclohexyl-2,2,6,6-tetramethyl-4-piperidinyl)-,Formamide, N-(1-ethenyl-5-hexenyl)-
The half-life of GLuc remains unclear. All GLuc-expressing vectors available for mammalian expression at NEB harbor the humanized codons for GLuc in which the secreted GLuc has activity similar to that of the native protein. Once GLuc is secreted into the culture medium, it is very stable. For example, ~20% of the GLuc activity was detectable after incubating a GLuc-containing sample at 99˚C for 15 minutes ...
Download the product note.. PS-Carbodiimide is a neutral, bound carbodiimide that can be used for the synthesis of amides and esters. The carbodiimide loading capacity is determined by 1H NMR (generation of Ac2O from AcOH in CDCl3). Amide formation may be conducted either without HOBt (Methods A), or with HOBt (Method B).. Excess HOBt can be scavenged after the reaction using MP-Carbonate Biotage® PS-Carbodiimide has been found to give superior results in comparison with N-Cyclohexylcarbodiimide-NI-Me PS resin and the quaternary carbodiimide resin P-EDC (Scheme 1, Table 1, click to enlarge table).. ...
Produkte werden einer Reihe von Tests zur Bestimmung der Funktionalität und Toxizität durch wachstumsfördernde Analyse unterzogen. Corning™ cellgro™ DMEM Klassische flüssige Zellkulturmedien fördern das Zellkulturwachstum und der Ersatz von Pyroxidin-HCl durch Pyroxidal gewährleistet eine verbesserte Stabilität im Vergleich zur ursprünglichen Formulierung. X6 100ml DMEM w 4.5 g/L gluc NaPy w/oL-glut phosph ...
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0055] Examples of the other radiation-sensitive compound include diphenyliodonium trifluoromethanesulfonate, diphenyliodonium nonafluoro-n-butanesulfonate, diphenyliodonium p-toluenesulfonate, diphenyliodonium 10-camphorsulfonate, diphenyliodonium 2-trifluoromethylbenzenesulfonate, diphenyliodonium 4-trifluoromethylbenzenesulfonate, diphenyliodonium 2,4-difluorobenzenesulfonate, diphenyliodonium 1,1,2,2-tetrafluoro-2-(norbornan-2-yl)ethanesulfonate, diphenyliodonium 2-(5-t-butoxycarbonyloxybicyclo[2.2.1]heptan-2-yl)-1,1,2,2-tetrafluoroeth- anesulfonate, diphenyliodonium 2-(6-t-butoxycarbonyloxybicyclo[2.2.1]heptan-2-yl)-1,1,2,2-tetrafluoroeth- anesulfonate, diphenyliodonium 1,1-difluoro-2-(bicyclo[2.2.1]heptan-2-yl)ethanesulfonate, bis(4-t-butylphenyl)iodonium trifluoromethanesulfonate, bis(4-t-butylphenyl)iodonium nonafluoro-n-butanesulfonate, bis(4-t-butylphenyl)iodonium p-toluenesulfonate, bis(4-t-butylphenyl)iodonium 10-camphorsulfonate, bis(4-t-butylphenyl)iodonium ...
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2-cyclohexyl-1-(1-dimethylamino-1H-pyrrol-2-yl)-propan-1-one - chemical structural formula, chemical names, chemical properties, synthesis references
0097]The compounds of this invention include the compounds themselves, as well as their salts, solvate, hydrate, polymorph, or prodrugs, if applicable. As used herein, the term "pharmaceutically acceptable salt," is a salt formed from, for example, an acid and a basic group of a compound of any one of the formulae disclosed herein. Illustrative salts include, but are not limited, to sulfate, citrate, acetate, chloride, bromide, iodide, nitrate, bisulfate, phosphate, acid phosphate, lactate, salicylate, acid citrate, tartrate, oleate, tannate, pantothenate, bitartrate, ascorbate, succinate, maleate, besylate, fumarate, gluconate, glucaronate, saccharate, formate, benzoate, glutamate, methanesulfonate, ethanesulfonate, benzenesulfonate, and p-toluenesulfonate salts. The term "pharmaceutically acceptable salt" also refers to a salt prepared from a compound of any one of the formulae disclosed herein having an acidic functional group, such as a carboxylic acid functional group, and a ...
Rhizopus fungus. Light micrograph of a section through hyphae (thread-like) in the mycelium of a Rhizopus sp. mould, showing sporangia (round, dark), within which spores are produced. Magnification: x13 when printed 10 centimetres wide. - Stock Image C024/9180
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66345-08-2 - LSDVOYHPXBALRS-UHFFFAOYSA-N - Phenol, 4-cyclohexyl-2-(1,1-dimethylethyl)-6-methyl- - Similar structures search, synonyms, formulas, resource links, and other chemical information.
When using this server please cite the following paper:. Zsila F, Bikadi Z, Malik D, Hari P, Pechan I, Berces A, Hazai E.. Evaluation of drug-human serum albumin binding interactions with support vector machine aided online automated docking.. Bioinformatics. 2011 May 18. ...
The ultimate aim of this site is to be a resource for applications of laser desorption ionization mass spectrometry (LDI MS). The site is maintained by members of the Venkat Panchagnula group. Our current research interests are in the broad areas of in bioanalysis, metabolomics, pesticide residue & food contaminant analysis, and surface chemistry.
The ultimate aim of this site is to be a resource for applications of laser desorption ionization mass spectrometry (LDI MS). The site is maintained by members of the Venkat Panchagnula group. Our current research interests are in the broad areas of in bioanalysis, metabolomics, pesticide residue & food contaminant analysis, and surface chemistry.
Fluorescent Dye derived from coumarine. Water insoluble and forms stable amide bond with primary amines via carbodiimide activation. (U0097) - Products - Abnova
Fluorescent dye derived from dipyrrometheneboron difluoride. Water insoluble and forms stable amide bond with primary amines via carbodiimide activation. (U0129) - Products - Abnova
Stronger than Tylose Powder. Rolled Fondant additive designed to add fondant to help dry faster & harder. Cake decorating is much easier with CMC to help with fondant.
Wong, C., K.L.; Chan, T.W.Dominic, 1997: Cationization processes in matrix-assisted laser desorption/ionization mass spectrometry: Attachment of divalent and trivalent metal ions
We report a graphene-doped resin target fabricated via a 3D printing technique for laser desorption/ionization mass spectrometry analysis. The graphene doped in the target acts as an inherent laser absorber and ionization promoter, thus permitting the direct analysis of samples without adding matrix. This work reve
Upon incubation of detergent-solubilized NADPH-cytochrome P-450 reductase and either cytochrome b5 or cytochrome c in the presence of a water-soluble carbodiimide, a 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide (EDC), covalently cross-linked compl
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8-(1-hydroxyethyl)-1,3-dimethyl-7H-purine-2,6-dione,8-cyclohexyl-1,3-dimethyl-7H-purine-2,6-dione,8-(cyclohexylamino)-1,3-dimethyl-7H-purine-2,6-dione,8-[(4-aminophenyl)methyl]-1,3-dimethyl-7H-purine-2,6-dione,8-cyclohexyl-1,3,7-trimethyl-purine-2,6-dione,8-cyclohexyloxy-1,3,7-trimethyl-purine-2,6-dione,8-hexyl-1,3,7-trimethyl-purine-2,6-dione,8-[1,3-dimethyl-2,6-bis(oxidanylidene)-7H-purin-8-yl]octanoic acid,8-[1-[1,3-dimethyl-2,6-bis(oxidanylidene)-7H-purin-8-yl]ethyl]-1,3-dimethyl-7H-purine-2,6-dione,8-[3-[1,3-dimethyl-2,6-bis(oxidanylidene)-7H-purin-8-yl]propyl]-1,3-dimethyl-7H-purine-2,6-dione,8-[4-[1,3-dimethyl-2,6-bis(oxidanylidene)-7H-purin-8-yl]butyl]-1,3-dimethyl-7H-purine-2,6-dione,8-[5-[1,3-dimethyl-2,6-bis(oxidanylidene)-7H-purin-8-yl]pentyl]-1,3-dimethyl-7H-purine-2,6-dione,8-[6-[1,3-dimethyl-2,6-bis(oxidanylidene)-7H-purin-8-yl]hexyl]-1,3-dimethyl-7H-purine-2,6-dione,8-(diphenylmethyl)-1,3,7-trimethyl-purine-2,6-dione,8-[8-[1,3-dimethyl-2,6-bis(oxidanylidene)-7H-purin-8-yl]octyl]-1,3
The compound Sn2O(CN2) was obtained as a brick-red crystalline powder from a solid-state reaction of equimolar amounts of SnCl2, SnO and Li2(CN2). Thermal analysis of the reaction indicates the formation of two intermediate compounds until Sn2O(CN2) is formed at 400 °C. The crystal structure of Sn2O(CN2) was
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In this paper, we report on the functionalization of silicon nanostructured (NanoSi) surface with an organic layer of nitrilotriacetic acid (NTA) and its subsequent use as an affinity surface-assisted laser desorption/ionization mass spectrometry (SA
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L. Qiao, P. Yang, B. Liu, N. Lion and C. Roussel et al. Plate for matrix-assisted laser desorption ionization mass spectrometry for, e.g. analyzing peptide, has substrate that is covered with light sensitive matrix with light absorber, charge carrier, probe molecule and photo-sensitizer, US8080784, 2008.. Detailed record ...
Quantitative PCR (qRT-PCR) analysis of sucrose and glucose responsive genes. The y axis refers to the relative expression ratio between target mRNA versus the r
Liu, Y. , Mirza, U. , Tang, J. , Porter, F. , Nagabhushan, T. , and Pramanik, B. N. 2003. Proteomic study of recombinant adenovirus 5 encoding human p53 by matrix-assisted laser desorption/ionization mass spectrometry in combination with database search. Int. J. Mass Spectrom. 226: 55-69. 99. Mirza, U. , Liu, Y. , Tang, J. , Pramanik, B. , and Nagabhushan, T. L. 2000. Extraction and characterization of adenovirus proteins from sodium dodecylsulfide polyacrylamide gel electrophoresis by matrixassisted laser desorption/ionization mass spectrometry. 5 μL/min was ~25,000 from ~16 nA of electrospray current transmitted into the interface. 1 μL/min, the peak intensity was ~24,000 from only 3 nA of electrospray current. Even though the electrospray current transmitted into the mass spectrometer dropped by 80% when the flow rate was lowered to 100 nL/min, the amount of gas-phase calibrant ions in the mass spectrometer remained the same as indicated by the detector response. This observation indicates ...
Frey BL, Ladror DT, Sondalle SB, Krusemark CJ, Jue AL, Coon JJ, Smith LM. Chemical Derivatization of Peptide Carboxyl Groups for Highly Efficient Electron Transfer Dissociation. Journal of the American Society for Mass Spectrometry. 2013 ;24:1710-1721. ...
Non-glutaraldehyde fixation of an organ or a prosthesis for implantation in a mammal is based upon carbodiimide treatment. A solution containing a sterilizing agent, such as EDC, in combination with a coupling enhancer, such as Sulfo-NHS, and a high concentration of a diamine cross linking agent is used. As a result, only minimal surface reduction occurs during fixation, and the resultant products show a dramatic increase in resistance to calcification.
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List of MeSH codes (D02) - WikipediaList of MeSH codes (D02) - Wikipedia

... cme-carbodiimide MeSH D02.491.203.385 --- dicyclohexylcarbodiimide MeSH D02.491.203.425 --- ethyl(dimethylaminopropyl) ... carbodiimide MeSH D02.491.485.100 --- azetidinecarboxylic acid MeSH D02.491.485.400 --- technetium tc 99m diethyl-iminodiacetic ...
more infohttps://en.wikipedia.org/wiki/List_of_MeSH_codes_(D02)

NAVER Academic > Search...NAVER Academic > Search...

Base Sequence, Binding Sites, CME-Carbodiimide, analogs & derivatives, pharmacology, Diethyl Pyrocarbonate, Magnesium, ...
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FREE CORR CME Online for Reading Radioprotection of tendon tissue via crosslinking and free radical scavenging. :: for[CME]FREE CORR CME Online for Reading "Radioprotection of tendon tissue via crosslinking and free radical scavenging." :: for[CME]

Crosslinkers included 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) and glucose, which were used to add exogenous ... Earn FREE CME Credit. Find this article helpful? Complete the brief multiple choice survey below the article to document your ... Earn FREE CME Ionizing radiation could supplement tissue bank screening to further reduce the probability of diseases ... The Accreditation Council for Continuing Medical Education requires that accredited CME providers evaluate and assess the ...
more infohttps://cme.formd.com/journal/3412/corr-clinical-orthopaedics-and-related-research/23788/radioprotection-of-tendon-tissue-via-crosslinking-and-free-radical-scavenging?q=corr

Patent US6683166 - Modified internucleoside linkages (ii) - Google PatentsPatent US6683166 - Modified internucleoside linkages (ii) - Google Patents

The alcohol 15 is converted in Step 4 to the aldehyde 16 such as by using a carbodiimide and DMSO. Aldehyde 16 and amine 12 are ... Particularly preferred analogs are 5-methylcytosine (abbreviated herein as "Cme"), 5-propynyluracil, 7-deazaxanthine, ... A solution of 15 in DMSO is treated with N,N′ dicyclohexyl carbodiimide (DCC) and dichloroacetic acid, and the mixture stirred ... but with the incorporation of the Cme(O-CH2-CH2-NFMOC)T dimer synthon. This dimer is constructed using the technique described ...
more infohttp://www.google.com/patents/US6683166?dq=%235,519,867

ACYCLIC NUCLEOSIDE DERIVATIVES - Patent applicationACYCLIC NUCLEOSIDE DERIVATIVES - Patent application

0328] A mixture of N-Boc-L-valine (528 mg; 2.1 mmol) and N,N-dicyclohexyl carbodiimide (250 mg; 1.21 mg) in dichloromethane ( ... CMe3); 116.4 (guaC5); 137.9 (guaC7); 151.7 (guaC4); 153.7 (guaC2); 155.7 (CONH); 158.8 (guaC6); 172.1 (CHCOO); 173.5 (CH2COO). ...
more infohttp://www.patentsencyclopedia.com/app/20120123119

CDC - NIOSH Pocket Guide to Chemical Hazards - Index of Chemical Names : CCDC - NIOSH Pocket Guide to Chemical Hazards - Index of Chemical Names : C

bis-CME. 542-88-1. KN1575000. Cadmium dust (as Cd) *. 7440-43-9 (metal). EU9800000 (metal). ... Carbodiimide. 420-04-2. GS5950000. Carbofuran *. 1563-66-2. FB9450000. Carbolic acid. 108-95-2. SJ3325000. ...
more infohttps://www.cdc.gov/niosh/npg/npgsyn-c.html

CMC - Allie: Result by abbreviationCMC - Allie: Result by abbreviation

CME (1 time). TAT (1 time). ≫. 2003 Discourse analysis of computer-mediated conferencing in World Wide Web-based continuing ... 1-cyclohexyl-3-(2-morpholinyl-(4)-ethyl)carbodiimide. (6 times) ≫. Biochemistry. (3 times). CLAP (1 time). DC (1 time). DFT (1 ... N-cyclohexyl-N-(2-morpholinoethyl)carbodiimide metho-p-toluenesulfonate. (14 times) ≫. Biochemistry. (10 times). EDC (6 times) ... 1982 Modification of a glucoamylase from Aspergillus saitoi with 1-cyclohexyl-3-(2-morpholinyl-(4)-ethyl)carbodiimide.. ≫ ...
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Gerald Fuller | Stanford Medicine ProfilesGerald Fuller | Stanford Medicine Profiles

Mechanical characterization of the cross-linked collagen conduits identified 1-ethyl-3-(3-dimethyl aminopropyl) carbodiimide ... CHEMENG 300, CME 330 (Aut). *Fluid Mechanics. CHEMENG 120A (Win). *Special Topics in Microrheology. CHEMENG 505 (Aut, Win, Spr ...
more infohttps://med.stanford.edu/profiles/gerald-fuller?tab=bio

Reactivity studies on [Cp′Fe(μ-I)] 2 : nitrido-, sulfido- and diselenide iron complexes derived from pseudohalide activation   ...Reactivity studies on [Cp′Fe(μ-I)] 2 : nitrido-, sulfido- and diselenide iron complexes derived from pseudohalide activation ...

CMe3)2-3,5]2 (1.94 Å.8 For comparison, the Cp′cent-Fe distances in [Cp′2Fe] (S = 0) and [Cp′2Fe][SbF6] (S = 1/2) are ... to form the diamagnetic isocyanate and carbodiimide complexes [Cp′Fe(CO)2(NCO)] (7) and [Cp′Fe(CNXyl)2(NCNXyl)] (8), ...
more infohttp://pubs.rsc.org/en/content/articlehtml/2017/sc/c7sc00570a

Northern blot | Aspergillus & Aspergillosis WebsiteNorthern blot | Aspergillus & Aspergillosis Website

... carbodiimide at 60 °C for 2 h as described previously [45]. Hybridisation was done at 37 °C overnight using P32 labelled probes ... CPD/CME. *Information leaflets. *Slide presentations*Website slide collection. *Imported Slides. *Powershow - Aspergillosis ...
more infohttps://www.aspergillus.org.uk/content/northern-blot

Previous years<...Previous years<...

Kazi H, Tudor F, Khan W (2017) Continued medical education (CME) focused on trauma: An opportunity for everyone not to be ... Bax D, Davidenko N, Gullberg D, et al (2017) Fundamental insight into the effect of carbodiimide crosslinking on cellular ...
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US Patent for Benzylpiperazine derivatives and their medical use Patent (Patent #  8,536,182 issued September 17, 2013) -...US Patent for Benzylpiperazine derivatives and their medical use Patent (Patent # 8,536,182 issued September 17, 2013) -...

The present invention provides a process for the preparation of a compound of formula (I) wherein A is phenyl and X is CMe2 or ... or N-dicyclohexyl carbodiimide (DCC), in a suitable solvent such as dichloromethane, dimethylformamide or mixtures thereof. ... Alternatively, a compound of formula (I) wherein A is phenyl and X is CMe2 or a pharmaceutically acceptable salt or solvate ...
more infohttps://patents.justia.com/patent/8536182

Inhibitors of IAP - Genentech, Inc.Inhibitors of IAP - Genentech, Inc.

In another embodiment, ring A is a group of formula II wherein Q4 is CR9, R9 is pyridin-2-yl and Q3 is C-Me. ... EDC: 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide;. EEDQ: 2-ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline ...
more infohttp://www.freepatentsonline.com/8110568.html

Download Photokinetics Theoretical Fundamentals And Applications 1998Download Photokinetics Theoretical Fundamentals And Applications 1998

038; Product Development at CME. John Nyhoff, MBA, has a Director of Financial Research and Development at CME. While the ... Order Tips Please be conclusions download; mystical hire-purchase; and carbodiimide; abstracts windowShare; when increasing ... CME values States models and angles on biosensors, especially in four technology Sensors: interest banks, industry horses, ...
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Plus itPlus it

... carbodiimide hydrochloride (EDC) as an activator and N,N-dimethylaminopyridine tosylate (DPTS) as a catalyst (9). SN38-TOA- ...
more infohttps://clincancerres.aacrjournals.org/content/24/11/2585

Plus itPlus it

Coupling was completed by a carbodiimide reaction linking the primary amino groups on TP53 protein and the carboxyl groups on ...
more infohttps://clincancerres.aacrjournals.org/content/23/19/5912

Cephalosporins having a 7-carboxy substituted .alpha.-etherified     oximinoarylacetamido) group - Patent # 4165430 -...Cephalosporins having a 7-carboxy substituted .alpha.-etherified oximinoarylacetamido) group - Patent # 4165430 -...

CMe.sub.2).. EXAMPLE A. This example illustrates the formulation of a pharmaceutical composition.. Dry Powder for Injection. ... for example a carbodiimide such asN,N-diethyl-, dipropyl- or diisopropylcarbodiimide, N,N-dicyclohexylcarbodiimide or N-ethyl ... CMe.sub.2).. EXAMPLE 26. (6R,7R)-7-[2-(2-Carboxyprop-2-yloxyimino)-2-phenylacetaamido]-3-(1-pyridini ummethyl)-ceph-3-em-4- ... CMe.sub.2).. EXAMPLE 25. (6R,7R)-3-Azidomethyl-7-[2-(2-carboxyprop-2-yloxyimino)-2-phenylacetamido]- ceph-3-em-4-carboxylic ...
more infohttp://www.patentgenius.com/patent/4165430.html

The Journal of Adhesive DentistryThe Journal of Adhesive Dentistry

Journals q.tv praxis q.tv patient Anatomie Präp-Trainer CME-Tests News ... Materials and Methods: Three chemical agents were investigated (proanthocyanidin-rich grape seed extract: GSE; carbodiimide ...
more infohttps://jad.quintessenz.de/index.php?doc=toc&year=2016&issue=6&new_language=de

ORGANIC ELECTROLUMINESCENCE DEVICE - Patent applicationORGANIC ELECTROLUMINESCENCE DEVICE - Patent application

CMe2-), a methylphenylmethylene group (--CMePh-), a diphenylmethylene group (--CPh2-), a 9,9-fluorenediyl group, a 1,1- ... a carbodiimide derivative, a fluorenylidenemethane derivative, a distyrylpyrazine derivative, an aromatic tetracarboxylic acid ...
more infohttp://www.patentsencyclopedia.com/app/20120178928

Hyaluronic acid scaffold has a neuroprotective effect in hemisection spinal cord injury in: Journal of Neurosurgery: Spine...Hyaluronic acid scaffold has a neuroprotective effect in hemisection spinal cord injury in: Journal of Neurosurgery: Spine...

First, we performed a 1-ethyl-3-[3-(dimethylamino) propyl]carbodiimide-mediated reaction in which DTP and HA reacted at pH 4.75 ... 1-Ethyl-3-[3-(dimethylamino)propyl]carbodiimide, 3,3′-dithiobis (propanoic acid) (DTP), dithiothreitol (DTT), and hydrazine ...
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Use of Bead-Based Serologic Assay to Evaluate Chikungunya Virus Epidemic, Haiti - Volume 24, Number 6-June 2018 - Emerging...Use of Bead-Based Serologic Assay to Evaluate Chikungunya Virus Epidemic, Haiti - Volume 24, Number 6-June 2018 - Emerging...

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