Clusterin
Molecular Chaperones
Glycoproteins
Complement Inactivator Proteins
Serum proteins that negatively regulate the cascade process of COMPLEMENT ACTIVATION. Uncontrolled complement activation and resulting cell lysis is potentially dangerous for the host. The complement system is tightly regulated by inactivators that accelerate the decay of intermediates and certain cell surface receptors.
Recovery following relief of unilateral ureteral obstruction in the neonatal rat. (1/535)
BACKGROUND: Obstructive nephropathy is a primary cause of renal insufficiency in infants and children. This study was designed to distinguish the reversible and irreversible cellular consequences of temporary unilateral ureteral obstruction (UUO) on the developing kidney. METHODS: Rats were subjected to UUO or sham operation in the first 48 hours of life, and the obstruction was removed five days later (or was left in place). Kidneys were removed for study 14 or 28 days later. In additional groups, kidneys were removed at the end of five days of obstruction. Immunoreactive distribution of renin was determined in arterioles, and the distribution of epidermal growth factor, transforming growth factor-beta1, clusterin, vimentin, and alpha-smooth muscle actin was determined in tubules and/or interstitium. The number of glomeruli, glomerular maturation, tubular atrophy, and interstitial collagen deposition was determined by morphometry. Renal cellular proliferation and apoptosis were measured by proliferating cell nuclear antigen and the TdT uridine-nick-end-label technique, respectively. The glomerular filtration rate was measured by inulin clearance. RESULTS: Renal microvascular renin maintained a fetal distribution with persistent UUO; this was partially reversed by the relief of obstruction. Although glomerular maturation was also delayed and glomerular volume was reduced by UUO, the relief of obstruction prevented the reduction in glomerular volume. Although relief of obstruction did not reverse a 40% reduction in the number of nephrons, the glomerular filtration rate of the postobstructed kidney was normal. The relief of obstruction did not improve tubular cell proliferation and only partially reduced apoptosis induced by UUO. This was associated with a persistent reduction in the tubular epidermal growth factor. In addition, the relief of obstruction reduced but did not normalize tubular expression of transforming growth factor-beta1, clusterin, and vimentin, all of which are evidence of persistent tubular injury. The relief of obstruction significantly reduced interstitial fibrosis and expression of alpha-smooth muscle actin by interstitial fibroblasts, but not to normal levels. CONCLUSIONS: The relief of obstruction in the neonatal rat attenuates, but does not reverse, renal vascular, glomerular, tubular, and interstitial injury resulting from five days of UUO. Hyperfiltration by remaining nephrons and residual tubulointerstitial injury in the postobstructed kidney are likely to lead to deterioration of renal function later in life. (+info)Clusterin has chaperone-like activity similar to that of small heat shock proteins. (2/535)
Clusterin is a highly conserved protein which is expressed at increased levels by many cell types in response to a broad variety of stress conditions. A genuine physiological function for clusterin has not yet been established. The results presented here demonstrate for the first time that clusterin has chaperone-like activity. At physiological concentrations, clusterin potently protected glutathione S-transferase and catalase from heat-induced precipitation and alpha-lactalbumin and bovine serum albumin from precipitation induced by reduction with dithiothreitol. Enzyme-linked immunosorbent assay data showed that clusterin bound preferentially to heat-stressed glutathione S-transferase and to dithiothreitol-treated bovine serum albumin and alpha-lactalbumin. Size exclusion chromatography and SDS-polyacrylamide gel electrophoresis analyses showed that clusterin formed high molecular weight complexes (HMW) with all four proteins tested. Small heat shock proteins (sHSP) also act in this way to prevent protein precipitation and protect cells from heat and other stresses. The stoichiometric subunit molar ratios of clusterin:stressed protein during formation of HMW complexes (which for the four proteins tested ranged from 1.0:1.3 to 1.0:11) is less than the reported ratios for sHSP-mediated formation of HMW complexes (1.0:1.0 or greater), indicating that clusterin is a very efficient chaperone. Our results suggest that clusterin may play a sHSP-like role in cytoprotection. (+info)Clusterin gene expression mediates resistance to apoptotic cell death induced by heat shock and oxidative stress. (3/535)
Clusterin is a widely expressed, well conserved, secreted glycoprotein, which is highly induced in tissues regressing as a consequence of apoptotic cell death in vivo. It has recently been shown that clusterin expression is only confined to surviving cells following the induction of apoptosis in vitro, suggesting that it is involved in cell survival rather than death. In the hypothesis that clusterin may be implicated in cellular responses to stress, clusterin gene expression was analyzed in the A431 human epidermoid cancer cell line following heat shock and oxidative stress. Our results show that both a transient heat shock (20 min at 42 degrees C) and various oxidative stresses, including hydrogen peroxide, superoxide anion, hyperoxia and UVA exposure, induce a strong increase in clusterin mRNA levels as assessed by northern blot. Nuclear run-on analysis suggests that transcriptional activation is involved in inducing clusterin mRNA in response to heat shock. Using pulse-chase analysis of control and heat shocked cells, it is shown that clusterin mRNA is translated and secreted, thus resulting in increased extracellular levels of the protein following heat shock. To investigate the function of clusterin in response to these stresses, clusterin anti-sense transfectants that stably express virtually no clusterin at the mRNA and protein level were generated in A431 cells. These anti-sense transfectants are shown to be highly sensitive to apoptotic cell death induced by heat shock or oxidative stress compared with wild-type A431 cells or control transfectants. Taken together, our results show that clusterin gene expression is induced in response to heat shock and oxidative stress in human A431 cells, and confers cellular protection against heat shock and oxidative stress. (+info)Effect of targeted expression of clusterin in photoreceptor cells on retinal development and differentiation. (4/535)
Clusterin expression is increased in tissues undergoing apoptosis, including neurodegenerative retina, but the causal relationships remain to be clarified. To test the hypothesis that overexpression of clusterin could induce apoptosis in neurons, transgenic mice were generated in which rat clusterin transgene was expressed in photoreceptor cells under the transcriptional control of the human interphotoreceptor retinoid-binding protein (IRBP) promoter. Photoreceptor cell death in the resulting transgenic mice was examined by histology and TUNEL techniques. The expression of the clusterin transgene was confirmed by in situ hybridization in the photoreceptor cells, and results in a complex pattern of clusterin protein distribution in the retina. A reduction in apoptotic staining in the transgenic retinas was observed from birth to postnatal day 15. These results suggest that clusterin is not causally involved in apoptotic mechanisms of photoreceptor cell death, but may relate to cytoprotective functions. (+info)Nerve growth factor and epidermal growth factor stimulate clusterin gene expression in PC12 cells. (5/535)
Clusterin (apolipoprotein J) is an extracellular glycoprotein that might exert functions in development, cell death and lipid transport. Clusterin gene expression is elevated at sites of tissue remodelling, such as differentiation and apoptosis; however, the signals responsible for this regulation have not been identified. We use here the clusterin gene as a model system to examine expression in PC12 cells under the control of differentiation and proliferation signals produced by nerve growth factor (NGF) and by epidermal growth factor (EGF) respectively. NGF induced clusterin mRNA, which preceded neurite outgrowth typical of neuronal differentiation. EGF also activated the clusterin mRNA, demonstrating that both proliferation and differentiation signals regulate the gene. To localize NGF- and EGF-responsive elements we isolated the clusterin promoter and tested it in PC12 cell transfections. A 2.5 kb promoter fragment and two 1.5 and 0.3 kb deletion mutants were inducible by NGF and EGF. The contribution to this response of a conserved activator protein 1 (AP-1) motif located in the 0.3 kb fragment was analysed by mutagenesis. The mutant promoter was not inducible by NGF or EGF, which identifies the AP-1 motif as an element responding to both factors. Binding studies with PC12 nuclear extracts showed that AP-1 binds to this sequence in the clusterin promoter. These findings suggest that NGF and EGF, which give differential gene regulation in PC12 cells, resulting in neuronal differentiation and proliferation respectively, use the common Ras/extracellular signal-regulated kinase/AP-1 signalling pathway to activate clusterin expression. (+info)Clusterin (SGP-2) gene expression is cell cycle dependent in normal human dermal fibroblasts. (6/535)
In confluent human dermal fibroblasts brought to quiescence (G0) by serum starvation, the S phase peaked at 24 h after serum re-addiction and G2/M phase peaked at 36 h. This was confirmed by titration of h-gas1 mRNA (a marker of G0 phase) and histone H3 (a marker of S phase). Clusterin mRNA accumulation progressively increased in cells proceeding to confluence after seeding and to quiescence upon serum starvation, and peaked at around G0, in parallel with h-gas1 mRNA. At 6 h (roughly G1 phase) clusterin transcript formed a second peak, followed by a gradual decrease until 36 h. Correspondence of clusterin protein accumulation to its mRNA occurred solely with regard to the G0 peak but not to the second one. The possible meaning of the cell cycle related clusterin gene expression is discussed. (+info)Isolation of Ku70-binding proteins (KUBs). (7/535)
DNA-dependent protein kinase (DNA-PK) plays a critical role in resealing DNA double-stand breaks by non-homologous end joining. Aside from DNA-PK, XRCC4 and DNA ligase IV, other proteins which play a role(s) in this repair pathway remain unknown; DNA-PK contains a catalytic subunit (DNA-PKcs) and a DNA binding subunit (Ku70 and Ku80). We isolated Ku70-binding proteins (KUB1-KUB4) using yeast two-hybrid analyses. Sequence analyses revealed KUB1 to be apolipoprotein J (apoJ), also known as X-ray-inducible transcript 8 (XIP8), testosterone-repressed prostate message-2 (TRPM-2) and clusterin. KUB2 is Ku80. KUB3 and KUB4 are unknown, >10 kb trans-cripts. Interactions of apoJ/XIP8 or KUB3 with Ku70 were confirmed by co-immunoprecipitation analyses in MCF-7:WS8 breast cancer or IMR-90 normal lung fibroblast cells, respectively. The interaction of apoJ/XIP8 with Ku70 was confirmed by far-western analyses. Stable over-expression of full-length apoJ/XIP8 in MCF-7:WS8 caused decreased Ku70/Ku80 DNA end binding that was restored by apoJ/XIP8 monoclonal antibodies. The role of apoJ/XIP8 in ionizing radiation resistance/sensitivity is under investigation. (+info)Targeted disruption of the murine lecithin:cholesterol acyltransferase gene is associated with reductions in plasma paraoxonase and platelet-activating factor acetylhydrolase activities but not in apolipoprotein J concentration. (8/535)
Lecithin:cholesteryl acyltransferase (LCAT) deficiency resulting from targeted disruption of the Lcat gene in the mouse is associated with dramatic decreases in HDL concentration and the accumulation of nascent HDL in the plasma. We examined whether LCAT deficiency in mice is associated with a concomitant decrease in two antioxidative enzymes, paraoxonase (PON) and platelet-activating factor acetylhydrolase (PAF-AH). In control Lcat (+/+) mice both these enzymes are transported on HDL. Compared to Lcat (+/+) mice, HDL-cholesterol is reduced 94% and apoA-I, 90%, in Lcat (-/-) mice; this reduction in HDL is paralleled by a 71% decrease in PAF-AH activity and in a 58% decrease in PON activity. Apolipoprotein J (apoJ) levels, rather than being decreased, were significantly (P = 0.01) higher (36%) in Lcat (-/-) than in Lcat (+/+) mice, and the apo J/PON ratio was 3-fold greater in Lcat (-/-) than in Lcat (+/+) animals. Even though apolipoprotein A-I (apoA-I) concentration and PON activity were drastically reduced, there was no reduction in apoA-I and PON liver mRNA levels suggesting that post-transcriptional events are responsible for the reduction of plasma PON and apoA-I levels. Fast protein liquid chromatography (FPLC) revealed that in Lcat (+/+) mice both PON and PAF-AH activity is associated with large, apoA-I-containing HDL particles (9.7 nm by non-denaturing gradient gel electrophoresis) while in Lcat (-/-) mice both enzymes are associated with small 8.2 nm particles. We conclude that the concomitant reduction in HDL and apoA-I concentrations and PON and PAF-AH activities is best explained by rapid clearance of the small HDL particles found in LCAT deficiency. (+info)
Hepatitis delta virus epigenetically enhances clusterin expression via histone acetylation in human hepatocellular carcinoma...
Secretory Clusterin: A Promising Target for Chemoresistance of Hepatocellular Carcinoma | Bentham Science
Interaction of complement and clusterin in renal injury<...
A Phase I Pharmacokinetic and Pharmacodynamic Study of OGX-011, a 2′-Methoxyethyl Antisense Oligonucleotide to Clusterin, in...
Clusterin protein diversity in the primate eye by Paul Wong, Bruce A. Pfeffer et al.
Clusterin: A potential target for improving response to antiestrogens
Apolipoprotein J Antibody 600-101-198
Clusterin - an apoptotic puzzle | Journal of Cell Science
Single Nucleotide Polymorphism rs11136000 of CLU Gene (Clusterin, ApoJ) and the Risk of Late-Onset Alzheimers Disease in a...
Clusterin in the Central Nervous System Historical Overview - Alzheimer Disease
Glial cell responses, complement and apolipoprotein J expression following axon injury in the neonatal rat
Clusterin and DNA repair: A new function in cancer for a key player in apoptosis and cell cycle control<...
Repeated exposure of human skin fibroblasts to UVB at subcytotoxic level triggers premature senescence through the TGF-β1...
Clusterin expression can be modulated by changes in TCF1-mediated Wnt signaling
Sulfated Glycoproteins, Glycolipids, and Glycosaminoglycans from Synaptic Plasma and Myelin Membranes: Isolation and...
Clusterin Antibody Monoclonal | APOJ Antibody | ProSpec
Clusterin Protein Human | Apolipoprotein J | ProSpec
Wong, Mol Vis 2000; 6:184-191. Figure 3.
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Sydney Research Online: Clusterin in Kidney Transplantation: Novel Biomarkers Versus Serum Creatinine for Early Prediction of...
Clusterin - Monoclonal Antibody - Antibodies | BioVendor Research and Diagnostics Products
Clusterin - Monoclonal Antibody - from Mouse - for Western blotting - Antibodies | BioVendor Research and Diagnostics Products
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Examples of errors detected by the V706 diagnostic
The Microwave Factor: In vitro effect of cell phone radiation on motility, DNA fragmentation and clusterin gene expression in...
Cell detachment and apoptosis induction of immortalized human prostate epithelial cells are associated with early accumulation...
Association between clusterin gene polymorphism rs11136000 and late‑onset Alzheimers disease susceptibility: A review and meta...
Expression of Clusterin in the Superficial Zone of Bovine Articular Cartilage -ORCA
The blockade of angiotensin II (Ang II) is a significant therapeutic | Discovery of Serotonin N-acetyltransferase Inhibitors
A Study Evaluating the Pain Palliation Benefit of Adding Custirsen to Docetaxel Retreatment or Cabazitaxel as Second Line...
Dementia study links gene with damage to brai | EurekAlert!
Distribution of clusterin in Alzheimer brain tissue. - PubMed - NCBI
Tissue expression of CLU - Staining in oral mucosa - The Human Protein Atlas
Protease-activated alpha-2-macroglobulin can inhibit amyloid formation by Amy R. Wyatt, Patrick Constantinescu et al.
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CLU monoclonal antibody, clone 7D1 - (MAB9601) - Products - Abnova
Combination of available tests helps predict Alzheimers disease risk
Association of TLR4 with Alzheimers disease risk and presymptomatic biomarkers of inflammation
OncoGenex Receives Confirmation from FDA on the Design of a Second Phase 3 Trial Evaluating OGX-011
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Environmental Rose Scented Envelope Sachet for clu
Gelsolin, clusterin and cd5l are the potential plasma biomarkers of amyotrophic lateral sclerosis with and without cognitive...
PLOS ONE: Biological Effects of Cigarette Smoke in Cultured Human Retinal Pigment Epithelial Cells
Glycoconjugates in the detection of alcohol abuse | Biochemical Society Transactions | Portland Press
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Tissue expression of CLU - Staining in vagina - The Human Protein Atlas
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Custirsen Shows no Survival Benefits in Metastatic Prostate Cancer | ESMO
A Multinational, Randomized, Open-Label Study of Custirsen In Patients With Advanced or Metastatic (Stage IV) Non-Small Cell...
Alzheimers disease risk gene APOE4 impairs function of brain immune cells
Bridging Integrator 1 ( BIN1) Genotypes Mediate Alzheimers Disease Risk by Altering Neuronal Degeneration - IOS Press
Protein expressions of Prx II and CLU in plasma by West | Open-i
Your Role : Robby Morris, CLU, CLTC, Financial Services Professional
CLU - PrimePCR Assay and Template | Life Science | Bio-Rad
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Clusterin
"Entrez Gene: clusterin". Koltai T (2014). "Clusterin: a key player in cancer chemoresistance and its inhibition". OncoTargets ... In humans, clusterin is encoded by the CLU gene on chromosome 8. CLU is a molecular chaperone responsible for aiding protein ... Clusterin was first identified in ram rete testis fluid where it showed signs of clustering with rat sertoli cells and ... Wei L, Xue T, Wang J, Chen B, Lei Y, Huang Y, Wang H, Xin X (Aug 2009). "Roles of clusterin in progression, chemoresistance and ...
CLUAP1
Clusterin associated protein 1, also known as CLUAP1, is a human gene. Model organisms have been used in the study of CLUAP1 ... "Entrez Gene: clusterin associated protein 1". Retrieved 2011-08-30. "Radiography data for Cluap1". Wellcome Trust Sanger ...
Custirsen
... acts as an anti-cancer drug by binding to the mRNA initiation site of the clusterin gene, reducing clusterin protein ... The results found that the recommended dose of Custirsen was 640 mg, with maximum decrease of clusterin blood plasma occurring ... The anti-apoptotic activity of clusterin in aiding tumour growth is due to interactions with protein complexes. These include: ... Chi KN, Zoubeidi A, Gleave ME (December 2008). "Custirsen (OGX-011): a second-generation antisense inhibitor of clusterin for ...
GOLM1
Zhou Y, Li L, Hu L, Peng T (March 2011). "Golgi phosphoprotein 2 (GOLPH2/GP73/GOLM1) interacts with secretory clusterin". ...
Low-density lipoprotein receptor-related protein 8
Bajari TM, Strasser V, Nimpf J, Schneider WJ (2003). "A model for modulation of leptin activity by association with clusterin ...
Kidney ischemia
Clusterin - Clusterin is a protein ubiquitously expressed in different cell lines. Secreted clusterin is involved in lipid ... The cells release clusterin as a response to cell stress. This is due to clusterin being able to protect the cell by reducing ... Kidney ischemia can be diagnosed by checking the levels of several biomarkers such as clusterin and cystatin C. While the ...
Follicular dendritic cell sarcoma
Clusterin is a heterodimeric protein that aids in the clearance of cellular debris and is involved with apoptosis. Clusterin ... Grogg, Karen L; Macon, William R; Kurtin, Paul J; Nascimento, Antonio G (2004). "A survey of clusterin and fascin expression in ... These cells are best visualized with immunostaining using the FDC markers CD21, CD35, R4/23, clusterin, and KiM4p. Marker ... Characteristically, FDCS have mircotubuloreticular structures (MTRS) and increased levels of intracellular clusterin. MTRS ...
LRP2
"Identification of glycoprotein 330 as an endocytic receptor for apolipoprotein J/clusterin". J. Biol. Chem. 270 (22): 13070-5. ...
NBPF1
Vandepoele K, Staes K, Andries V, van Roy F (April 2010). "Chibby interacts with NBPF1 and clusterin, two candidate tumor ...
Human serum albumin
"Identification of human plasma proteins as major clients for the extracellular chaperone clusterin". The Journal of Biological ...
Gene silencing
Antiapoptotic proteins, such as clusterin and survivin, are often expressed in cancer cells. Clusterin and survivin-targeting ... "Nucleotide-based therapies targeting clusterin chemosensitize human lung adenocarcinoma cells both in vitro and in vivo". ...
Multiple sclerosis biomarkers
It appears together with clusterin and complement C3, markers of complement-mediated inflammatory reactions. Also Fibroblast ...
Mothers against decapentaplegic homolog 3
Lee KB, Jeon JH, Choi I, Kwon OY, Yu K, You KH (February 2008). "Clusterin, a novel modulator of TGF-beta signaling, is ...
Albert Hofman
Plasma clusterin and the risk of Alzheimer disease. JAMA. 2011 Apr 6;305(13):1322-6. Solouki AM, et al. A genome-wide ...
Reverse phase protein lysate microarray
9 (3). Proteome Science , Full text , Development of reverse phase protein microarrays for the validation of clusterin, a mid- ...
Martin Gleave
Gleave's team was recognized in 2010 as the first in the world to develop an anti-clusterin agent. Richard D. Williams MD ...
MMP25
2003). "Clusterin, an abundant serum factor, is a possible negative regulator of MT6-MMP/MMP-25 produced by neutrophils". J. ...
Epstein-Barr virus-associated lymphoproliferative diseases
In these cases, the FD cells express FD-cell markers (e.g. CD21, CD23, CD35, clusterin, podoplanin, gamma-synuclein) and in >90 ...
Complement membrane attack complex
These fluid phase complexes do not bind to cell membranes and are ultimately scavenged by clusterin and vitronectin, two ...
Sertoli cell
Clusterin, a soluble molecule with functions similar to CD59, forms a complex with Granzyme B and inhibits activation of ...
SAT1 (gene)
... is accompanied by significant changes in the levels of expression of polyamine metabolism regulatory genes and clusterin ( ...
Piotr Piecuch
Li, W.; Piecuch, P. (2010). "Multi-level Extension of the Cluster-In-Molecule Local Correlation Methodology: Merging Coupled- ...
Bronze Star Medal
Oak leaf cluster - In the Army, Air Force, and Space Force, the oak leaf cluster is worn to denote additional awards. 5/16 inch ...
Vancomycin
... clusterin, and osteopontin (OPN), and in humans, insulin-like growth factor binding protein 7 (IGFBP7) as part of the ...
CLU
... the gene for clusterin CLU (programming language) Clu (Tron), fictional character from the Tron franchise Chartered Life ...
HeuristicLab
The following list gives an overview of the problems supported by HeuristicLab: Artificial Ant Classification Clusterin ...
Nvidia DGX
... turnkey cluster-in-a-box solution that can be purchased, leased, or rented by smaller companies or individuals who want to ...
ACAMPs
Among soluble inhibitors there are factor H, C1 inhibitor, C4b-binding protein, factor I, S protein or clusterin, the membrane- ...
Anaplastic large-cell lymphoma
For example, expression of CD56, MUC1 (also termed EMA for epithelial membrane antigen), and clusterin and strong uniform ...
Clusterin - Monoclonal Antibody - from Mouse - for Immunohistochemistry - Antibodies | BioVendor Research and Diagnostics...
The extracellular chaperone Clusterin enhances Tau aggregate seeding in a cellular model | bioRxiv
Upon interaction with Tau aggregates, Clusterin stabilizes highly potent, soluble seed species. Tau/Clusterin complexes enter ... The extracellular chaperone Clusterin enhances Tau aggregate seeding in a cellular model. View ORCID ProfilePatricia Yuste- ... Thus, upregulation of Clusterin, as observed in AD patients, may enhance Tau seeding and possibly accelerate the spreading of ... Here we show in a cellular model system and in neurons that Clusterin, an abundant extracellular chaperone, strongly enhances ...
"The extracellular chaperone clusterin sequesters oligomeric forms of t" by Priyanka Narayan, Angel Orte et al.
... all of which interact with clusterin to form long-lived, stable complexes. Consequently, clusterin is able to influence both ... These results not only elucidate the protective role of clusterin but also provide a molecular basis for the genetic link ... We have examined the interactions between human clusterin and the Alzheimers disease-associated amyloid-β 1-40 peptide (Aβ 1- ... clusterin, has been identified as a newly-discovered risk factor in Alzheimers disease. ...
Human - Clusterin - Monoclonal Antibody - from Mouse - for Immunohistochemistry - Antibodies | BioVendor Research and...
Alzheimer Disease: Practice Essentials, Background, Anatomy
Clusterin. Clusterin, a plasma protein, plays an important role in the pathogenesis of AD. In one study, clusterin was ... Plasma clusterin and the risk of Alzheimer disease. JAMA. 2011 Apr 6. 305(13):1322-6. [QxMD MEDLINE Link]. ... Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease. Arch Gen ... 19] A study by Schrijvers et al notes that although plasma clusterin levels are significantly associated with baseline ...
Peripheral administration of human recombinant ApoJ/clusterin modulates brain beta-amyloid levels in APP23 mice | Alzheimer's...
ApoJ/clusterin is a multifunctional protein highly expressed in the brain. The implication of ApoJ in β-amyloid (Aβ) ... Peripheral administration of human recombinant ApoJ/clusterin modulates brain beta-amyloid levels in APP23 mice. Alzforum ... Peripheral administration of human recombinant ApoJ/clusterin modulates brain beta-amyloid levels in APP23 mice. Access & ...
High clusterin expression correlates with a poor outcome in stage II colorectal cancers.
The role of clusterin in tumor growth and progression remains unclear. Overexpression of cytoplasmic clusterin has been studied ... Clusterin/*metabolism. Colorectal Neoplasms/*metabolism/pathology. Female. Humans. Immunoenzyme Techniques. In Situ Nick-End ... We assessed levels of clusterin expression in a group of stage II colorectal cancer patients to assess its utility as a ... High clusterin expression correlates with a poor outcome in stage II colorectal cancers.. ...
Clusterin regulates transthyretin amyloidosis<...
The ability of clusterin to influence amyloid fibril formation prompted us to investigate whether clusterin is capable of ... The ability of clusterin to influence amyloid fibril formation prompted us to investigate whether clusterin is capable of ... The ability of clusterin to influence amyloid fibril formation prompted us to investigate whether clusterin is capable of ... The ability of clusterin to influence amyloid fibril formation prompted us to investigate whether clusterin is capable of ...
LEGENDplex Human Apo J (Clusterin) Capture Bead A7, 13X
Apolipoprotein J (Clusterin), Urine - Nexelis, a Q² Solutions Company
The clusterin assay is a solid phase ELISA designed to measure humin clusterin in cell culture supernates, serum, plasma, urine ... Mature human clusterin shares a 77% amino acid sequence identity with mouse and rat clusterin. ... Determination of urine clusterin has been shown to have utility in tracking kidney injury in the animals. Thus, it detects ... Clusterin (also know as apolipoprotein J, sulfated glycoprotein 2 (SGP-2), TRPM-2, and SP-40) is a secreted multifunctional ...
IMSEAR at SEARO: Relationship between Clusterin Gene Expression and In-vitro Sperm Characteristics in Caprine Semen
Relationship between Clusterin Gene Expression and In-vitro Sperm Characteristics in Caprine Semen. Journal of Animal Research ... Relationship between Clusterin Gene Expression and In-vitro Sperm Characteristics in Caprine Semen. ... The present experiment was undertaken to study the relationship between clusterin (CLU) gene expression and in vitro sperm ...
Solved: Why is the "Edit" button in the "Indexer Clusterin... - Splunk Community
Mouse Clusterin ELISA KIT Mouse Elisa Kit Elisa kit Solarbio Life Science
Mature mouse Clusterin shares 77% and 93% amino acid sequence identity with human and rat Clusterin, respectively.? ... Clusterin, also known as Apolipoprotein J, Sulfated Glycoprotein 2 (SGP-2), TRPM-2, and SP-40, is a secreted multifunctional ... It also participates in the control of cell proliferation, apoptosis, and carcinogenesis (1, 2). Clusterin is expressed in ... Mouse Clusterin is synthesized as a precursor that contains two coiled coil domains, two nuclear localization signals (NLS), ...
Identification of human plasma proteins as major clients for the extracellular chaperone clusterin
Clusterin (CLU) is an extracellular chaperone that is likely to play an important role in protein folding quality control. This ... Clusterin (CLU) is an extracellular chaperone that is likely to play an important role in protein folding quality control. This ... Identification of human plasma proteins as major clients for the extracellular chaperone clusterin Journal Article Download ... Identification of human plasma proteins as major clients for the extracellular chaperone clusterin. Journal of Biological ...
Results for 'Complement' | Abcam: antibodies, proteins, kits...
New VyprVPN server cluster in Miami! | Giganews
Golden Frog added a new VyprVPN server cluster in Miami! Feedback from Golden Frog Ideas motivated the addition of this new server location, and Golden Frog encourages Giganews members using VyprVPN to share or vote up ideas. Your feedback is extremely useful to the Golden Frog team and they take all ideas seriously.. The new server cluster is available for all VyprVPN protocols, including PPTP, L2TP/IPsec, and OpenVPN.. How to Access the New Miami VyprVPN Server Cluster:. ...
Frontiers | Genetic variant rs11136000 upregulates clusterin expression and reduces Alzheimer's disease risk
Clusterin (CLU) is an extracellular chaperone involved in reducing amyloid beta (Aβ) toxicity and aggregation. Although ... Clusterin (CLU) is an extracellular chaperone involved in reducing amyloid beta (Aβ) toxicity and aggregation. Although ... Genetic variant rs11136000 upregulates clusterin expression and reduces Alzheimers disease risk. by admin ...
Prostate - MeSH - NCBI
Kidney-based in vitro models for drug-induced toxicity testing | SpringerLink
Wu C-Y, Yang H-Y, Chien H-P, Tseng M-H, Huang J-L (2018) Urinary clusterin-a novel urinary biomarker associated with pediatric ... Hidaka S, Kranzlin B, Gretz N, Witzgall R (2002) Urinary clusterin levels in the rat correlate with the severity of tubular ... Dieterle F, Perentes E, Cordier A et al (2010a) Urinary clusterin, cystatin C, beta2-microglobulin and total protein as markers ... Another early marker of renal damage is urinary clusterin (CLU), which is a heterodimeric glycoprotein that contributes to ...
MySQL :: MySQL InnoDB Cluster in Oracle Public Cloud: A Tutorial
You have now acquired the basic knowledge to properly create and configure a cluster using Oracle Public Cloud and MySQL Cloud Service instances, including how to bootstrap a remote cluster so that you can access it locally. This scenario is useful when you dont want to expose the servers where MySQL Server is running but instead provide the IP address of another server which just handles the application traffic.. Theres a lot of other functionalities that we still want to share with you, so stay tuned for Part II of this series!. If you have any questions about the basic setup described here, please let us know here in the comments. As always, thank you for using MySQL!. ...
ANALISIS PERSEBARAN KASUS COVID-19 DI JAWA BARAT MENGGUNAKAN METODE K-MEANS CLUSTERIN
| Seminar Nasional Sistem...
Gene: [08p21/CLU] clusterin (complement lysis inhibitor, SP-40,40, apolipoprotein J); sulfated glycoprotein 2 (testosterone...
Song W[Author] - Search Results - PubMed
Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid | Nature
Search of: CLI - List Results - ClinicalTrials.gov
corneal dystrophy - Ontology Report - Rat Genome Database
Search Ageing-Associated Genes in Humans
Purified CHO Legumain Protein | AG65-0423-01-Z | Immunology Consultatnt Laboratory
Extracellular chaperone clusterin1
- The extracellular chaperone clusterin sequesters oligomeric forms of t" by Priyanka Narayan, Angel Orte et al. (edu.au)
Ability of clusterin2
- The ability of clusterin to influence amyloid fibril formation prompted us to investigate whether clusterin is capable of inhibiting TTR amyloidosis. (elsevier.com)
- The ability of clusterin to bind and neutralize non-oxidatively modified LDL reduces cytotoxicity in atherosclerotic plaques. (nexelis.com)
Inhibitor2
- We also demonstrated that clusterin is an effective inhibitor of L55P TTR amyloidosis, the most aggressive form of TTR diseases. (elsevier.com)
- Clusterin in Alzheimer's disease: An amyloidogenic inhibitor of amyloid formation? (grnet.gr)
Alzheimer's4
- In recent genome-wide association studies, the extracellular chaperone protein, clusterin, has been identified as a newly-discovered risk factor in Alzheimer's disease. (edu.au)
- We have examined the interactions between human clusterin and the Alzheimer's disease-associated amyloid-β 1-40 peptide (Aβ 1-40 ), which is prone to aggregate into an ensemble of oligomeric intermediates implicated in both the proliferation of amyloid fibrils and in neuronal toxicity. (edu.au)
- These results not only elucidate the protective role of clusterin but also provide a molecular basis for the genetic link between clusterin and Alzheimer's disease. (edu.au)
- The chaperone function of clusterin helps to reduce the accumulation of the β-amyloid fibrils and damage due to amyloid plaques in Alzheimer's disease. (nexelis.com)
Tumor3
- The role of clusterin in tumor growth and progression remains unclear. (lenus.ie)
- Increased circulating levels of clusterin enhance tumor aggressiveness by inhibiting apoptosis and by promoting the epithelial to messenchymal transition. (nexelis.com)
- Evaluation of genetic polymorphisms in clusterin and tumor necrosis factor-alpha genes in South Indian individuals with pseudoexfoliation syndrome. (cdc.gov)
Amino acid sequence ide1
- Mature human clusterin shares a 77% amino acid sequence identity with mouse and rat clusterin. (nexelis.com)
Protein3
- Clusterin (also know as apolipoprotein J, sulfated glycoprotein 2 (SGP-2), TRPM-2, and SP-40) is a secreted multifunctional protein that was named for its ability to induce cellular clustering. (nexelis.com)
- Clusterin (CLU) is an extracellular chaperone that is likely to play an important role in protein folding quality control. (edu.au)
- Custirsen utilizes second-generation antisense technology, licensed from Isis Pharmaceuticals (NASDAQ: ISIS), to target and inhibit production of clusterin, a protein involved in resistance of cancer tumors to treatments. (higcapital.com)
Complexes2
- Tau/Clusterin complexes enter recipient cells via endocytosis and compromise the endolysosomal compartment, allowing transfer to the cytosol where they propagate aggregation of endogenous Tau. (biorxiv.org)
- Using highly sensitive single-molecule fluorescence methods, we have found that Aβ 1-40 forms a heterogeneous distribution of small oligomers (from dimers to 50-mers), all of which interact with clusterin to form long-lived, stable complexes. (edu.au)
Gene2
Chaperone3
- Here we show in a cellular model system and in neurons that Clusterin, an abundant extracellular chaperone, strongly enhances Tau aggregate seeding. (biorxiv.org)
- Clusterin has recently been proposed to play a role as an extracellular molecular chaperone, affecting the fibril formation of amyloidogenic proteins. (elsevier.com)
- Clusterin is ubiquitously expressed and appears to function as a secreted MOLECULAR CHAPERONE. (nih.gov)
Progression1
- 2010). Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease. (bvsalud.org)
Genetic1
- Influence of clusterin genetic variants on IOP elevation in pseudoexfoliation syndrome and pseudoexfoliative glaucoma in Turkish population. (cdc.gov)
Amyloid2
- Here, we report that clusterin strongly interacts with wild-type TTR and TTR variants V30M and L55P under acidic conditions, and blocks the amyloid fibril formation of TTR variants. (elsevier.com)
- In particular, the amyloid fibril formation of V30M TTR in the presence of clusterin is reduced to level similar to wild-type TTR. (elsevier.com)
Assay1
- The clusterin assay is a solid phase ELISA designed to measure humin clusterin in cell culture supernates, serum, plasma, urine and saliva. (nexelis.com)
Apoptosis1
- Glicoproteína heterodimérica, muy estable, que se expresa en muy diversos trastornos fisiológicos graves, como el CÁNCER, la APOPTOSIS y algunas TRASTORNOS NEUROLÓGICOS. (bvsalud.org)
Variants1
- Association of clusterin (CLU) variants and exfoliation syndrome: An analysis in two Caucasian studies and a meta-analysis. (cdc.gov)
Pathology1
- Thus, upregulation of Clusterin, as observed in AD patients, may enhance Tau seeding and possibly accelerate the spreading of Tau pathology. (biorxiv.org)
Urine1
- Determination of urine clusterin has been shown to have utility in tracking kidney injury in the animals. (nexelis.com)
Influence1
- Consequently, clusterin is able to influence both the aggregation and disaggregation of Aβ 1-40 by sequestration of the Aβ oligomers. (edu.au)
Human2
- Human clusterin is synthesized as a precursor that contains two coiled domains, three nuclear localization signals (NLS), and one heparin binding domain. (nexelis.com)
- An alternately spliced 50 kDa isoform o f human clusterin remains intracellularly and is neither glycosylated nor cleaved into α and β chains. (nexelis.com)
Plasma1
- Prevention of Dominant IgG Adsorption on Nanocarriers in IgG-Enriched Blood Plasma by Clusterin Precoating. (mpg.de)
Levels3
- We assessed levels of clusterin expression in a group of stage II colorectal cancer patients to assess its utility as a prognostic marker. (lenus.ie)
- Clusterin levels are associated with poor survival in stage II colorectal cancer. (lenus.ie)
- High levels (µg/mL) of clusterin circulate predominantly as a component of high-density lipoprotein particles, and these are internalized and degraded through interactions with LPR-2/megalin. (nexelis.com)
CANCER1
- however, no correlation between clusterin expression and survival in colorectal cancer has been identified to date. (lenus.ie)
High1
- High clusterin expression correlates with a poor outcome in stage II colorectal cancers. (lenus.ie)
Appears1
- The mechanism by which clusterin inhibits TTR amyloidosis appears to be through stabilization of TTR tetrameric structure. (elsevier.com)
Function2
- This function contrasts with the cyoprotective effect of secreted clusterin. (nexelis.com)
- In addition, clusterin (two out of six isoforms) and haptoglobin (four isoforms) were up-regulated in bGH mice as a function of age. (nih.gov)