A primary headache disorder that is characterized by severe, strictly unilateral PAIN which is orbital, supraorbital, temporal or in any combination of these sites, lasting 15-180 min. occurring 1 to 8 times a day. The attacks are associated with one or more of the following, all of which are ipsilateral: conjunctival injection, lacrimation, nasal congestion, rhinorrhea, facial SWEATING, eyelid EDEMA, and miosis. (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)
The symptom of PAIN in the cranial region. It may be an isolated benign occurrence or manifestation of a wide variety of HEADACHE DISORDERS.
Secondary headache disorders attributed to a variety of cranial or cervical vascular disorders, such as BRAIN ISCHEMIA; INTRACRANIAL HEMORRHAGES; and CENTRAL NERVOUS SYSTEM VASCULAR MALFORMATIONS.
Various conditions with the symptom of HEADACHE. Headache disorders are classified into major groups, such as PRIMARY HEADACHE DISORDERS (based on characteristics of their headache symptoms) and SECONDARY HEADACHE DISORDERS (based on their etiologies). (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)
A common primary headache disorder, characterized by a dull, non-pulsatile, diffuse, band-like (or vice-like) PAIN of mild to moderate intensity in the HEAD; SCALP; or NECK. The subtypes are classified by frequency and severity of symptoms. There is no clear cause even though it has been associated with MUSCLE CONTRACTION and stress. (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)
A class of disabling primary headache disorders, characterized by recurrent unilateral pulsatile headaches. The two major subtypes are common migraine (without aura) and classic migraine (with aura or neurological symptoms). (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)
A serotonin agonist that acts selectively at 5HT1 receptors. It is used in the treatment of MIGRAINE DISORDERS.
Primary headache disorders that show symptoms caused by the activation of the AUTONOMIC NERVOUS SYSTEM of the TRIGEMINAL NERVE. These autonomic features include redness and tearing of the EYE, nasal congestion or discharge, facial SWEATING and other symptoms. Most subgroups show unilateral cranial PAIN.
Conditions in which the primary symptom is HEADACHE and the headache cannot be attributed to any known causes.
A small space in the skull between the MAXILLA and the SPHENOID BONE, medial to the pterygomaxillary fissure, and connecting to the NASAL CAVITY via the sphenopalatine foramen.
The 5th and largest cranial nerve. The trigeminal nerve is a mixed motor and sensory nerve. The larger sensory part forms the ophthalmic, mandibular, and maxillary nerves which carry afferents sensitive to external or internal stimuli from the skin, muscles, and joints of the face and mouth and from the teeth. Most of these fibers originate from cells of the TRIGEMINAL GANGLION and project to the TRIGEMINAL NUCLEUS of the brain stem. The smaller motor part arises from the brain stem trigeminal motor nucleus and innervates the muscles of mastication.
Acyclic branched or unbranched hydrocarbons having two carbon-carbon double bonds.
A subtype of migraine disorder, characterized by recurrent attacks of reversible neurological symptoms (aura) that precede or accompany the headache. Aura may include a combination of sensory disturbances, such as blurred VISION; HALLUCINATIONS; VERTIGO; NUMBNESS; and difficulty in concentrating and speaking. Aura is usually followed by features of the COMMON MIGRAINE, such as PHOTOPHOBIA; PHONOPHOBIA; and NAUSEA. (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)
The 31 paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment. The spinal nerve plexuses and the spinal roots are also included.
Recurrent unilateral pulsatile headaches, not preceded or accompanied by an aura, in attacks lasting 4-72 hours. It is characterized by PAIN of moderate to severe intensity; aggravated by physical activity; and associated with NAUSEA and / or PHOTOPHOBIA and PHONOPHOBIA. (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)
A primary headache disorder that is similar to the CLUSTER HEADACHE with unilateral head pain, but differs by its multiple short severe attacks. It is usually seen in females, and may be responsive to non-steroidal-anti-inflammatory drugs (NSAIDS).
Decarboxylated monoamine derivatives of TRYPTOPHAN.
Conditions with HEADACHE symptom that can be attributed to a variety of causes including BRAIN VASCULAR DISORDERS; WOUNDS AND INJURIES; INFECTION; drug use or its withdrawal.
Unequal pupil size, which may represent a benign physiologic variant or a manifestation of disease. Pathologic anisocoria reflects an abnormality in the musculature of the iris (IRIS DISEASES) or in the parasympathetic or sympathetic pathways that innervate the pupil. Physiologic anisocoria refers to an asymmetry of pupil diameter, usually less than 2mm, that is not associated with disease.
A set of statistical methods used to group variables or observations into strongly inter-related subgroups. In epidemiology, it may be used to analyze a closely grouped series of events or cases of disease or other health-related phenomenon with well-defined distribution patterns in relation to time or place or both.
The caudal portion of the nucleus of the spinal trigeminal tract (TRIGEMINAL NUCLEUS, SPINAL), a nucleus involved with pain and temperature sensation.
Bony cavity that holds the eyeball and its associated tissues and appendages.
Pupillary constriction. This may result from congenital absence of the dilatator pupillary muscle, defective sympathetic innervation, or irritation of the CONJUNCTIVA or CORNEA.
Ventral part of the DIENCEPHALON extending from the region of the OPTIC CHIASM to the caudal border of the MAMMILLARY BODIES and forming the inferior and lateral walls of the THIRD VENTRICLE.

The trigeminovascular system in humans: pathophysiologic implications for primary headache syndromes of the neural influences on the cerebral circulation. (1/129)

Primary headache syndromes, such as cluster headache and migraine, are widely described as vascular headaches, although considerable clinical evidence suggests that both are primarily driven from the brain. The shared anatomical and physiologic substrate for both of these clinical problems is the neural innervation of the cranial circulation. Functional imaging with positron emission tomography has shed light on the genesis of both syndromes, documenting activation in the midbrain and pons in migraine and in the hypothalamic gray in cluster headache. These areas are involved in the pain process in a permissive or triggering manner rather than as a response to first-division nociceptive pain impulses. In a positron emission tomography study in cluster headache, however, activation in the region of the major basal arteries was observed. This is likely to result from vasodilation of these vessels during the acute pain attack as opposed to the rest state in cluster headache, and represents the first convincing activation of neural vasodilator mechanisms in humans. The observation of vasodilation was also made in an experimental trigeminal pain study, which concluded that the observed dilation of these vessels in trigeminal pain is not inherent to a specific headache syndrome, but rather is a feature of the trigeminal neural innervation of the cranial circulation. Clinical and animal data suggest that the observed vasodilation is, in part, an effect of a trigeminoparasympathetic reflex. The data presented here review these developments in the physiology of the trigeminovascular system, which demand renewed consideration of the neural influences at work in many primary headaches and, thus, further consideration of the physiology of the neural innervation of the cranial circulation. We take the view that the known physiologic and pathophysiologic mechanisms of the systems involved dictate that these disorders should be collectively regarded as neurovascular headaches to emphasize the interaction between nerves and vessels, which is the underlying characteristic of these syndromes. Moreover, the syndromes can be understood only by a detailed study of the cerebrovascular physiologic mechanisms that underpin their expression.  (+info)

Cluster headache-like attack as an opening symptom of a unilateral infarction of the cervical cord: persistent anaesthesia and dysaesthesia to cold stimuli. (2/129)

A 54 year old man experienced excruciating left retro-orbital pain with lacrimation and redness of the eye representative of a cluster headache attack. This was followed by left hemiparesis with plegia of the lower limb and left Horner's syndrome. Five days later the hemiparesis recovered while the patient developed hypoanaesthesia to cold stimuli that evoked painful burning dysaesthesia on the right side below the C4 level. MRI disclosed a discrete infarct in the left lateral aspect of the cord at C2 level concomitant to a left vertebral artery thrombosis. This limited infarct and the clinical symptoms suggest a hypoperfusion in the peripheral arterial system of the left hemicord, supplied both by the anterior and posterior spinal arteries. Cluster headache-like attack and persistent dysaesthesia to cold stimuli are discussed respectively in view of the central sympathetic involvement and partial spinothalamic system dysfunction.  (+info)

Cluster headache-like disorder in childhood. (3/129)

This paper reviews the diagnostic features of cluster headache-like disorder and describes its presentation in childhood. Case note summaries of patients with this condition are presented in the context of a brief summary of the literature. Four patients (two girls; aged 12 to 15 years) with cluster headache-like disorder were seen over a period of four years in the paediatric neurology department of Birmingham Children's Hospital. Their histories and clinical courses are described. All had a history of "thrashing around" or bizarre behaviour during attacks, which had distracted attention from the headache and seemed to contribute to delay in diagnosis. It appears that cluster headache-like disorder does occur in childhood but is not common and can be mistaken for other conditions. A history of thrashing around accompanied by headache is very suggestive. Recognition of the symptoms in the general paediatric clinic would allow rapid diagnosis.  (+info)

Cluster-tic syndrome: report of five new cases. (4/129)

The so-called short lasting primary headaches include heterogenic entities that can be divided between those without pronounced autonomic activation and those where this activation is evident, which includes the cluster-tic syndrome. We report five new cases with age closer to the trigeminal neuralgia's one, and concomitance of cluster headache and trigeminal neuralgia, which is less frequent in the literature. We also discuss briefly the pathophysiology of these clinical entities, suggesting that the trigeminus nerve is a common pathway of pain manifestation.  (+info)

Cluster headache in women: clinical characteristics and comparison with cluster headache in men. (5/129)

OBJECTIVE: To study the clinical characteristics of cluster headache in women. Cluster headache is a disorder of men (male to female ratio 6-7:1). METHODS: Retrospective chart review to identify all women diagnosed with cluster headache at an academic headache centre from January 1995 through July 1998. RESULTS: Thirty two women and 69 men were identified. The mean age of onset of cluster headache was 29.4 years in women versus 31.3 years in men. Two peaks of onset in women (2nd and 5th decade) were identified compared with one in men (3rd decade). Episodic cluster headache was present in 75% of women and 77% of men. Women and men had on average 3 attacks a day, but attack duration was shorter in women (67.2 minutes v 88.2 minutes). Cluster headache period duration (11.1 weeks v 10 weeks) and remission periods (21.1 months v 23.1 months) were similar in women and men. Miosis and ptosis seemed to be less common in women (miosis 13.3% v 24.6%, ptosis 41.9% v 58.1%) whereas lacrimation and nasal congestion/rhinorrhoea were almost equally prevalent in women and men. Women had more nausea than men (62.5% v 43.5%, p=0.09) and significantly more vomiting (46.9% v 17.4%, p=0.003). Photophobia occurred in 75% of women and 81.2% of men, and phonophobia occurred in 50% of women and 47.8% of men. CONCLUSIONS: The clinical characteristics of cluster headache in women are very similar to those in men. Women develop the disorder at an earlier age of onset and experience more "migrainous symptoms" with cluster headache, especially vomiting. Both men and women have frequent photophobia and phonophobia with cluster headache attacks. These symptoms are not included in the International Headache Society cluster headache criteria, suggesting the need for possible criteria revision.  (+info)

Management of primary headache: serendipity and science. (6/129)

Most patients find some relief with current agents, even though a poor understanding of the causes of chronic primary headache limits prophylaxis and treatment. The author reviews current preventive and treatment strategies for migraine, chronic tension headache, cluster headache, and substance withdrawal headache.  (+info)

Episodic paroxysmal hemicrania with seasonal variation: case report and the EPH-cluster headache continuum hypothesis. (7/129)

Episodic paroxysmal hemicrania (EPH) is a rare disorder characterized by frequent, daily attacks of short-lived, unilateral headache with accompanying ipsilateral autonomic features. EPH has attack periods which last weeks to months separated by remission intervals lasting months to years, however, a seasonal variation has never been reported in EPH. We report a new case of EPH with a clear seasonal pattern: a 32-year-old woman with a right-sided headache for 17 years. Pain occurred with a seasonal variation, with bouts lasting one month (usually in the first months of the year) and remission periods lasting around 11 months. During these periods she had headache from three to five times per day, lasting from 15 to 30 minutes, without any particular period preference. There were no precipitating or aggravating factors. Tearing and conjunctival injection accompanied ipsilaterally the pain. Previous treatments provided no pain relief. She completely responded to indomethacin 75 mg daily. After three years, the pain recurred with longer attack duration and was just relieved with prednisone. We also propose a new hypothesis: the EPH-cluster headache continuum.  (+info)

Persistence of attacks of cluster headache after trigeminal nerve root section. (8/129)

Cluster headache is a strictly unilateral headache that occurs in association with cranial autonomic features. We report a patient with a trigeminal nerve section who continued to have attacks. A 59-year-old man described a 14-year history of left-sided episodes of excruciating pain centred on the retro-orbital and orbital regions. These episodes lasted 1-4 h, recurring 2-3 times daily. The attacks were associated with ipsilateral ptosis, conjunctival injection, lacrimation, rhinorrhoea and facial flushing. From 1986 to 1988, he had trials of medications without any benefit. In February 1988, he had complete surgical section of the left trigeminal sensory root that shortened the attacks in length for 1 month without change in their frequency or character. In April 1988, he had further surgical exploration and the root was found to be completely excised; post-operatively, there was no change in the symptoms. From 1988 to 1999, he had a number of medications, including verapamil and indomethacin, all of which were ineffective. Prednisolone 30 mg orally daily rendered the patient completely pain free. Sumatriptan 100 mg orally and 6 mg subcutaneously aborted the attack after approximately 45 and 15 min, respectively. He was completely anaesthetic over the entire left trigeminal distribution. Left corneal reflex was absent. Motor function of the left trigeminal nerve was preserved. Neurological and physical examination was otherwise normal. MRI scan showed a marked reduction in the calibre of the left trigeminal nerve from the nerve root exit zone in the pons to Meckel's cave. An ECG-gated three-dimensional multislab MRI inflow angiogram was performed. No dilatation was observed in the left internal carotid artery during the cluster attack. Blink reflexes were elicited with a standard electrode and stimulus. Stimulation of the left supraorbital nerve produced neither ipsilateral nor contralateral blink reflex response. Stimulation of the right supraorbital nerve produced an ipsilateral response with a mean R2 onset latency of 36 ms and a contralateral response with a mean R2 onset latency of 32 ms. Lack of ipsilateral vessel dilatation makes the role of vascular factors in the initiation of cluster attacks questionable. With complete section of the left trigeminal sensory root the brain would perceive neither vasodilatation nor a peripheral neural inflammatory process; however, the patient continued to have an excellent response to sumatriptan. The case illustrates that cluster headache may be generated primarily from within the brain, and that triptans may have anti-headache effects through an entirely central mechanism.  (+info)

A cluster headache is a type of primary headache disorder characterized by severe, one-sided headaches that occur in clusters, meaning they happen several times a day for several weeks or months and then go into remission for a period of time. The pain of a cluster headache is typically intense and often described as a sharp, stabbing, or burning sensation around the eye or temple on one side of the head.

Cluster headaches are relatively rare, affecting fewer than 1 in 1000 people. They tend to affect men more often than women and usually start between the ages of 20 and 50. The exact cause of cluster headaches is not fully understood, but they are thought to be related to abnormalities in the hypothalamus, a part of the brain that regulates various bodily functions, including hormone production and sleep-wake cycles.

Cluster headache attacks can last from 15 minutes to several hours and may be accompanied by other symptoms such as redness or tearing of the eye, runny nose, sweating, or swelling on the affected side of the face. During a cluster period, headaches typically occur at the same time each day, often at night or in the early morning.

Cluster headaches can be treated with various medications, including triptans, oxygen therapy, and local anesthetics. Preventive treatments such as verapamil, lithium, or corticosteroids may also be used to reduce the frequency and severity of cluster headache attacks during a cluster period.

A headache is defined as pain or discomfort in the head, scalp, or neck. It can be a symptom of various underlying conditions such as stress, sinus congestion, migraine, or more serious issues like meningitis or concussion. Headaches can vary in intensity, ranging from mild to severe, and may be accompanied by other symptoms such as nausea, vomiting, or sensitivity to light and sound. There are over 150 different types of headaches, including tension headaches, cluster headaches, and sinus headaches, each with their own specific characteristics and causes.

A vascular headache is a type of headache that is primarily caused by disturbances in the blood vessels that supply blood to the brain and surrounding tissues. The two most common types of vascular headaches are migraines and cluster headaches.

Migraines are characterized by intense, throbbing pain on one or both sides of the head, often accompanied by nausea, vomiting, sensitivity to light and sound, and visual disturbances known as auras. They can last from several hours to days.

Cluster headaches, on the other hand, are characterized by severe, one-sided pain around the eye or temple that occurs in clusters, meaning they occur several times a day for weeks or months, followed by periods of remission. Cluster headaches are often accompanied by symptoms such as redness and tearing of the eye, nasal congestion, and sweating on the affected side of the face.

Other types of vascular headaches include toxic headaches caused by exposure to certain substances or drugs, and headaches associated with high blood pressure or other medical conditions that affect the blood vessels in the brain.

Headache disorders refer to a group of conditions characterized by recurrent headaches that cause significant distress and impairment in daily functioning. The most common types of headache disorders are tension-type headaches, migraines, and cluster headaches.

Tension-type headaches are typically described as a dull, aching sensation around the head and neck, often accompanied by tightness or pressure. Migraines, on the other hand, are usually characterized by moderate to severe throbbing pain on one or both sides of the head, often accompanied by nausea, vomiting, sensitivity to light and sound, and visual disturbances.

Cluster headaches are relatively rare but extremely painful, with attacks lasting from 15 minutes to three hours and occurring several times a day for weeks or months. They typically affect one side of the head and are often accompanied by symptoms such as redness and tearing of the eye, nasal congestion, and sweating on the affected side of the face.

Headache disorders can have a significant impact on quality of life, and effective treatment often requires a multidisciplinary approach that may include medication, lifestyle changes, and behavioral therapies.

A tension-type headache (TTH) is a common primary headache disorder characterized by mild to moderate, non-throbbing head pain, often described as a tight band or pressure surrounding the head. The pain typically occurs on both sides of the head and may be accompanied by symptoms such as scalp tenderness, neck stiffness, and light or sound sensitivity.

TTHs are classified into two main categories: episodic and chronic. Episodic TTHs occur less than 15 days per month, while chronic TTHs occur 15 or more days per month for at least three months. The exact cause of tension-type headaches is not fully understood, but they are believed to be related to muscle tension, stress, anxiety, and poor posture.

Treatment options for TTHs include over-the-counter pain relievers such as ibuprofen or acetaminophen, relaxation techniques, stress management, physical therapy, and lifestyle modifications. In some cases, prescription medications may be necessary to manage chronic TTHs.

A migraine disorder is a neurological condition characterized by recurrent headaches that often involve one side of the head and are accompanied by various symptoms such as nausea, vomiting, sensitivity to light and sound, and visual disturbances. Migraines can last from several hours to days and can be severely debilitating. The exact cause of migraines is not fully understood, but they are believed to result from a combination of genetic and environmental factors that affect the brain and blood vessels. There are different types of migraines, including migraine without aura, migraine with aura, chronic migraine, and others, each with its own specific set of symptoms and diagnostic criteria. Treatment typically involves a combination of lifestyle changes, medications, and behavioral therapies to manage symptoms and prevent future attacks.

Sumatriptan is a selective serotonin receptor agonist, specifically targeting the 5-HT1D and 5-HT1B receptors. It is primarily used to treat migraines and cluster headaches. Sumatriptan works by narrowing blood vessels around the brain and reducing inflammation that leads to migraine symptoms.

The medication comes in various forms, including tablets, injectables, and nasal sprays. Common side effects of sumatriptan include feelings of warmth or hotness, tingling, tightness, pressure, heaviness, pain, or burning in the neck, throat, jaw, chest, or arms.

It is important to note that sumatriptan should not be used if a patient has a history of heart disease, stroke, or uncontrolled high blood pressure. Additionally, it should not be taken within 24 hours of using another migraine medication containing ergotamine or similar drugs such as dihydroergotamine, methysergide, or caffeine-containing analgesics.

Trigeminal Autonomic Cephalalgias (TACs) is a group of primary headache disorders characterized by unilateral, severe head pain associated with ipsilateral cranial autonomic features. The International Classification of Headache Disorders, 3rd edition (ICHD-3) classifies TACs into four types:

1. Cluster Headache: Severe, strictly unilateral, orbital, supraorbital, or temporal pain lasting 15 minutes to three hours and occurring in clusters (usually at the same time of day for several weeks or months). The attacks are associated with ipsilateral cranial autonomic symptoms such as conjunctival injection, lacrimation, nasal congestion, rhinorrhea, forehead sweating, eyelid edema, and/or pupillary miosis.
2. Paroxysmal Hemicrania: Short-lasting (2-30 minutes) but recurrent attacks of severe unilateral head pain accompanied by ipsilateral cranial autonomic features. The attacks occur more than five times a day and are often associated with agitation or restlessness during the attack.
3. Short-lasting Unilateral Neuralgiform Headache Attacks (SUNHA): This category includes two subtypes: SUNCT (Short-lasting Unilateral Neuralgiform headache attacks with Conjunctival injection and Tearing) and SUNA (Short-lasting Unilateral Neuralgiform headache attacks with Autonomic symptoms). These disorders are characterized by moderate to severe unilateral head pain lasting 5 minutes to 6 hours, accompanied by cranial autonomic features.
4. Hemicrania Continua: A continuous, strictly unilateral headache of mild to moderate intensity with occasional exacerbations of severe pain. The attacks are associated with ipsilateral cranial autonomic symptoms and/or migrainous features such as photophobia, phonophobia, or nausea.

TACs are considered rare disorders, and their pathophysiology is not entirely understood. However, it is believed that they involve the trigeminal nerve and its connections to the brainstem. Treatment typically involves medications targeting the underlying mechanisms of these headaches, such as triptans for migraine-like features or anticonvulsants for neuralgiform pain. In some cases, invasive procedures like nerve blocks or neurostimulation may be considered.

Primary headache disorders are a group of headaches that are not caused by an underlying medical condition or structural problem. They are considered to be separate medical entities and include:

1. Migraine: A recurring headache that typically causes moderate to severe throbbing pain, often on one side of the head. It is commonly accompanied by nausea, vomiting, and sensitivity to light and sound.
2. Tension-type headache (TTH): The most common type of headache, characterized by a pressing or tightening sensation around the forehead or back of the head and neck. It is usually not aggravated by physical activity and does not cause nausea or vomiting.
3. Cluster headache: A rare but extremely painful type of headache that occurs in clusters, meaning they happen several times a day for weeks or months, followed by periods of remission. The pain is usually one-sided, centered around the eye and often accompanied by redness, tearing, and nasal congestion.
4. New daily persistent headache (NDPH): A type of headache that starts suddenly and persists every day for weeks or months. It can be similar to tension-type headaches or migraines but is not caused by an underlying medical condition.
5. Trigeminal autonomic cephalalgias (TACs): A group of primary headache disorders characterized by severe pain on one side of the head, often accompanied by symptoms such as redness, tearing, and nasal congestion. Cluster headaches are a type of TAC.
6. Other primary headache disorders: These include rare conditions such as hemicrania continua, paroxysmal hemicrania, and short-lasting unilateral neuralgiform headache attacks.

Primary headache disorders can significantly impact a person's quality of life and ability to function. Treatment typically involves medication, lifestyle changes, and behavioral therapies.

The pterygopalatine fossa is a small, irregularly shaped space located in the skull, lateral to the nasal cavity and inferior to the orbit. It serves as a critical communications center for several important nerves, arteries, and veins that provide sensory innervation, vasomotor control, and blood supply to various structures in the head and neck region.

The following are some key components of the pterygopalatine fossa:

1. Nerves: The pterygopalatine ganglion is a major component of this fossa, which contains postganglionic parasympathetic fibers, sympathetic fibers, and sensory fibers from various nerves, including the maxillary nerve (V2), greater petrosal nerve, deep petrosal nerve, and nerve of the pterygoid canal.

2. Arteries: The maxillary artery, a branch of the external carotid artery, enters the fossa through the foramen rotundum and divides into several branches that supply various structures in the head and neck region, such as the sphenopalatine artery, posterior superior alveolar artery, infraorbital artery, and greater palatine artery.

3. Veins: The pterygoid venous plexus is a complex network of veins located in and around the fossa that communicates with various venous systems, including the facial vein, cavernous sinus, and inferior ophthalmic vein.

The pterygopalatine fossa plays an essential role in several physiological functions, such as lacrimation, salivation, and vasodilation of blood vessels in the nasal cavity and paranasal sinuses. Additionally, it is a potential site for the spread of infection or neoplasm from the oral cavity, nasal cavity, or paranasal sinuses to other regions of the head and neck.

The trigeminal nerve, also known as the fifth cranial nerve or CNV, is a paired nerve that carries both sensory and motor information. It has three major branches: ophthalmic (V1), maxillary (V2), and mandibular (V3). The ophthalmic branch provides sensation to the forehead, eyes, and upper portion of the nose; the maxillary branch supplies sensation to the lower eyelid, cheek, nasal cavity, and upper lip; and the mandibular branch is responsible for sensation in the lower lip, chin, and parts of the oral cavity, as well as motor function to the muscles involved in chewing. The trigeminal nerve plays a crucial role in sensations of touch, pain, temperature, and pressure in the face and mouth, and it also contributes to biting, chewing, and swallowing functions.

Alkadienes are organic compounds that contain two carbon-carbon double bonds in their molecular structure. The term "alka" refers to the presence of hydrocarbons, while "diene" indicates the presence of two double bonds. These compounds can be classified as either conjugated or non-conjugated dienes based on the arrangement of the double bonds.

Conjugated dienes have their double bonds adjacent to each other, separated by a single bond, while non-conjugated dienes have at least one methylene group (-CH2-) separating the double bonds. The presence and positioning of these double bonds can significantly affect the chemical and physical properties of alkadienes, including their reactivity, stability, and spectral characteristics.

Alkadienes are important intermediates in various chemical reactions and have applications in the production of polymers, pharmaceuticals, and other industrial products. However, they can also be produced naturally by some plants and microorganisms as part of their metabolic processes.

"Migraine with Aura" is a neurological condition that is formally defined by the International Classification of Headache Disorders (ICHD) as follows:

"An migraine attack with focal neurological symptoms that usually develop gradually over 5 to 20 minutes and last for less than 60 minutes. Motor weakness is not a feature of the aura."

The symptoms of an aura may include visual disturbances such as flickering lights, zigzag lines, or blind spots; sensory disturbances such as tingling or numbness in the face, arms, or legs; and speech or language difficulties. These symptoms are caused by abnormal electrical activity in the brain and typically precede or accompany a migraine headache, although they can also occur without a headache.

It's important to note that not all people who experience migraines will have an aura, and some people may have an aura without a headache. If you are experiencing symptoms of a migraine with aura or any other type of headache, it is recommended that you consult with a healthcare professional for proper diagnosis and treatment.

Spinal nerves are the bundles of nerve fibers that transmit signals between the spinal cord and the rest of the body. There are 31 pairs of spinal nerves in the human body, which can be divided into five regions: 8 cervical, 12 thoracic, 5 lumbar, 5 sacral, and 1 coccygeal. Each spinal nerve carries both sensory information (such as touch, temperature, and pain) from the periphery to the spinal cord, and motor information (such as muscle control) from the spinal cord to the muscles and other structures in the body. Spinal nerves also contain autonomic fibers that regulate involuntary functions such as heart rate, digestion, and blood pressure.

"Migraine without Aura," also known as "Common Migraine," is defined by the International Classification of Headache Disorders (ICHD-3) as follows:

"Headaches fulfilling criteria C and D:

C. At least five attacks fulfilling criterion B

B. Headache lasting 4-72 hours (untreated or unsuccessfully treated)

1. a) Has at least two of the following characteristics:
b) One-sided location
c) Pulsating quality
d) Moderate or severe pain intensity
e) Aggravation by or causing avoidance of routine physical activity (e.g., walking or climbing stairs)

D. During headache at least one of the following:

1. a) Nausea and/or vomiting
2. b) Photophobia and phonophobia"

In simpler terms, Migraine without Aura is a recurring headache disorder characterized by moderate to severe headaches that typically occur on one side of the head, have a pulsating quality, and are aggravated by physical activity. The headaches last between 4 and 72 hours if not treated or if treatment is unsuccessful. Additionally, during the headache, at least one of the following symptoms must be present: nausea/vomiting, sensitivity to light (photophobia), or sensitivity to sound (phonophobia).

Paroxysmal Hemicrania is a rare primary headache disorder characterized by severe, unilateral (one-sided) head pain that occurs in brief, recurring episodes or attacks. The pain is usually located in the temple, eye, or face and can be accompanied by ipsilateral (same side) autonomic symptoms such as redness of the eye, tearing, nasal congestion, or sweating.

The headaches typically last between 2-30 minutes and occur several times a day, often increasing in frequency over time. The disorder predominantly affects women and tends to begin in middle age. Paroxysmal Hemicrania is considered a type of trigeminal autonomic cephalalgia (TAC) and is thought to be caused by abnormal activation of the trigeminovascular system, which supplies nerves to the head and face.

The disorder is uniquely responsive to indomethacin, a nonsteroidal anti-inflammatory drug (NSAID), with most patients experiencing complete or significant relief at doses of 150-225 mg/day. Failure to respond to indomethacin should raise suspicion for other types of headache disorders.

Tryptamines are a class of organic compounds that contain a tryptamine skeleton, which is a combination of an indole ring and a ethylamine side chain. They are commonly found in nature and can be synthesized in the lab. Some tryptamines have psychedelic properties and are used as recreational drugs, such as dimethyltryptamine (DMT) and psilocybin. Others have important roles in the human body, such as serotonin, which is a neurotransmitter that regulates mood, appetite, and sleep. Tryptamines can also be found in some plants and animals, including certain species of mushrooms, toads, and catnip.

Secondary headache disorders refer to headaches that are caused by an underlying medical condition, structural abnormality, or injury. These headaches can have various characteristics and patterns, and their symptoms may mimic those of primary headache disorders such as migraine or tension-type headaches. However, in order to diagnose a secondary headache disorder, the healthcare provider must identify and address the underlying cause.

Examples of conditions that can cause secondary headache disorders include:

* Intracranial hemorrhage (bleeding in the brain)
* Brain tumors or other space-occupying lesions
* Meningitis or encephalitis (infections of the membranes surrounding the brain or the brain itself)
* Sinusitis or other respiratory infections
* Temporomandibular joint disorder (TMJ)
* Giant cell arteritis (a condition that affects the blood vessels in the head and neck)
* Substance use or withdrawal (such as from caffeine or alcohol)
* Medications (such as nitroglycerin or blood pressure-lowering drugs)

It is important to note that secondary headache disorders can be serious and even life-threatening, so it is essential to seek medical attention if you experience a new or unusual headache, especially if it is accompanied by other symptoms such as fever, weakness, numbness, or difficulty speaking.

Anisocoria is a medical term that refers to an inequality in the size of the pupils in each eye. The pupil is the black, circular opening in the center of the iris (the colored part of the eye) that allows light to enter and strike the retina. Normally, the pupils are equal in size and react similarly when exposed to light or darkness. However, in anisocoria, one pupil is larger or smaller than the other.

Anisocoria can be caused by various factors, including neurological conditions, trauma, eye diseases, or medications that affect the pupillary reflex. In some cases, anisocoria may be a normal variant and not indicative of any underlying medical condition. However, if it is a new finding or associated with other symptoms such as pain, headache, vision changes, or decreased level of consciousness, it should be evaluated by a healthcare professional to determine the cause and appropriate treatment.

Cluster analysis is a statistical method used to group similar objects or data points together based on their characteristics or features. In medical and healthcare research, cluster analysis can be used to identify patterns or relationships within complex datasets, such as patient records or genetic information. This technique can help researchers to classify patients into distinct subgroups based on their symptoms, diagnoses, or other variables, which can inform more personalized treatment plans or public health interventions.

Cluster analysis involves several steps, including:

1. Data preparation: The researcher must first collect and clean the data, ensuring that it is complete and free from errors. This may involve removing outlier values or missing data points.
2. Distance measurement: Next, the researcher must determine how to measure the distance between each pair of data points. Common methods include Euclidean distance (the straight-line distance between two points) or Manhattan distance (the distance between two points along a grid).
3. Clustering algorithm: The researcher then applies a clustering algorithm, which groups similar data points together based on their distances from one another. Common algorithms include hierarchical clustering (which creates a tree-like structure of clusters) or k-means clustering (which assigns each data point to the nearest centroid).
4. Validation: Finally, the researcher must validate the results of the cluster analysis by evaluating the stability and robustness of the clusters. This may involve re-running the analysis with different distance measures or clustering algorithms, or comparing the results to external criteria.

Cluster analysis is a powerful tool for identifying patterns and relationships within complex datasets, but it requires careful consideration of the data preparation, distance measurement, and validation steps to ensure accurate and meaningful results.

The Trigeminal Caudal Nucleus, also known as the nucleus of the spinal trigeminal tract or spinal trigeminal nucleus, is a component of the trigeminal nerve sensory nuclear complex located in the brainstem. It is responsible for receiving and processing pain and temperature information from the face and head, particularly from the areas innervated by the ophthalmic (V1) and maxillary (V2) divisions of the trigeminal nerve. The neurons within this nucleus then project to other brainstem regions and ultimately to the thalamus, which relays this information to the cerebral cortex for conscious perception.

In medical terms, the orbit refers to the bony cavity or socket in the skull that contains and protects the eye (eyeball) and its associated structures, including muscles, nerves, blood vessels, fat, and the lacrimal gland. The orbit is made up of several bones: the frontal bone, sphenoid bone, zygomatic bone, maxilla bone, and palatine bone. These bones form a pyramid-like shape that provides protection for the eye while also allowing for a range of movements.

Miosis is the medical term for the constriction or narrowing of the pupil of the eye. It's a normal response to close up viewing, as well as a reaction to certain drugs like opioids and pilocarpine. Conversely, dilation of the pupils is called mydriasis. Miosis can be also a symptom of certain medical conditions such as Horner's syndrome or third cranial nerve palsy.

The hypothalamus is a small, vital region of the brain that lies just below the thalamus and forms part of the limbic system. It plays a crucial role in many important functions including:

1. Regulation of body temperature, hunger, thirst, fatigue, sleep, and circadian rhythms.
2. Production and regulation of hormones through its connection with the pituitary gland (the hypophysis). It controls the release of various hormones by producing releasing and inhibiting factors that regulate the anterior pituitary's function.
3. Emotional responses, behavior, and memory formation through its connections with the limbic system structures like the amygdala and hippocampus.
4. Autonomic nervous system regulation, which controls involuntary physiological functions such as heart rate, blood pressure, and digestion.
5. Regulation of the immune system by interacting with the autonomic nervous system.

Damage to the hypothalamus can lead to various disorders like diabetes insipidus, growth hormone deficiency, altered temperature regulation, sleep disturbances, and emotional or behavioral changes.

The cause of cluster headache is unknown. Cluster headaches were historically described as vascular headaches, with the belief ... Trigeminal neuralgia is a unilateral headache syndrome, or "cluster-like" headache. Management for cluster headache is divided ... Cluster headaches are named for the occurrence of groups of headache attacks (clusters). They have also been referred to as " ... Cluster-like head pain may be diagnosed as secondary headache rather than cluster headache. A detailed oral history aids ...
The Organization for Understanding Cluster Headaches (O.U.C.H.) was a 501(c)(3) non-profit organization that assisted cluster ... The UK equivalent, Organisation for the Understanding of Cluster Headache or OUCH (UK), is a registered charity.[citation ... "OUCH(uk) , Organisation for the Understanding of Cluster Headache ,". ouchuk.org. Retrieved 15 December 2015. OUCH Archived 10 ... Organisation for the Understanding of Cluster Headache Belgium or OUCH Belgium is the same non-profit organization for Belgium ...
Cluster headaches are relatively uncommon. They affect only 1-3 per thousand people in the world. Cluster headaches affect ... of headaches are primary headaches. Most of these primary headaches are tension headaches. Most people with tension headaches ... The first step to diagnosing a headache is to determine if the headache is old or new. A "new headache" can be a headache that ... The ICHD-2 classification defines migraines, tension-types headaches, cluster headache and other trigeminal autonomic headache ...
Cluster headache Garza, Ivan; Robertson, Carrie E.; Smith, Jonathan H.; Whealy, Mark E. (2022). "102. Headache and other ... Rebound headaches frequently occur daily, can be very painful and are a common cause of chronic daily headache. They typically ... A medication overuse headache (MOH), also known as a rebound headache, usually occurs when painkillers are taken frequently to ... It was defined as a secondary headache, with the aim of emphasising excessive drug intake as the basis of this form of headache ...
ISBN 978-1-929007-88-2. Nesbitt AD, Goadsby PJ (Apr 11, 2012). "Cluster headache". BMJ (Clinical Research Ed.) (Review). 344: ... and cluster headaches. The facial nerve (VII) controls most muscles of facial expression, supplies the sensation of taste from ...
"Cluster headache variant. Spectrum of a new headache syndrome". Arch. Neurol. 38 (11): 705-9. doi:10.1001/archneur. ... While attacks tend to be more frequent at night, no circadian periodicity such as in cluster headache can be observed. The ... The factor that allows hemicrania continua and its exacerbations to be differentiated from migraine and cluster headache is ... The International Headache Society's International Classification of Headache Disorders classifies hemicrania continua as a ...
Beck, E.; Sieber, W. J.; Trejo, R. (2005). "Management of cluster headache". American Family Physician. 71 (4): 717-724. PMID ... Shift work also increases the risk of developing cluster headaches, heart attacks, fatigue, stress, sexual dysfunction, ... However, 10% more participants reported adverse effects (nausea and headache) while taking modafinil. In post-marketing ...
"Verapamil and Cluster Headache: Still a Mystery. A Narrative Review of Efficacy, Mechanisms and Perspectives". Headache. 59 (8 ... It may also be used for the prevention of migraines and cluster headaches. It is given by mouth or by injection into a vein. ... Verapamil is used to treat the condition cluster headache. Tentative evidence supports the use of verapamil topically to treat ... Beck E, Sieber WJ, Trejo R (February 2005). "Management of cluster headache". American Family Physician. 71 (4): 717-724. PMID ...
Post M (2015). "Cluster Headache Patient Survey: 5-MeO-DALT". Figshare. doi:10.6084/M9.FIGSHARE.1372467.V3. Post M (2014). " ... Numerous anecdotal reports and a small-scale trial indicate the potential of 5-MeO-DALT for the treatment of cluster headache, ... Brandt RB, Doesborg PG, Haan J, Ferrari MD, Fronczek R (February 2020). "Pharmacotherapy for Cluster Headache". CNS Drugs. ... "Treatment of Cluster Headache Symptoms using Synthetic Tryptamine N,N-Diallyl-5 Methoxytryptamine". Figshare. doi:10.6084/M9. ...
"Verapamil for cluster headache. Clinical pharmacology and possible mode of action". Headache: The Journal of Head and Face Pain ...
Cluster-like head pain may be diagnosed as secondary headache rather than cluster headache. Under-recognition of CH by health ... "IHS Classification ICHD-II 3.1 Cluster headache". The International Headache Society. Archived from the original on 3 November ... Cluster headaches are often misdiagnosed, mismanaged, or undiagnosed for many years; they may be confused with migraine, " ... Tfelt-Hansen, Peer C.; Jensen, Rigmor H. (July 2012). "Management of Cluster Headache". CNS Drugs. 26 (7): 571-580. doi:10.2165 ...
376-. ISBN 978-84-7429-200-8. Sicuteri F (1988). "Antiandrogenic medication of cluster headache". Int J Clin Pharmacol Res. 8 ( ... CPA has been studied in the treatment of cluster headaches in men. Estradiol valerate/cyproterone acetate Ethinylestradiol/ ...
... s are a family of tryptamine-based drugs used as abortive medication in the treatment of migraines and cluster headaches ... Law, S; Derry, S; Moore, R. A. (2013). "Triptans for acute cluster headache". The Cochrane Database of Systematic Reviews. 7 (7 ... Triptans have largely replaced ergotamines, an older class of medications used to relieve migraine and cluster headaches. ... Triptans are effective for the treatment of cluster headache. This has been demonstrated for subcutaneous sumatriptan and ...
"This hand-held device is approved to treat cluster headaches". NBC News. Retrieved 2019-03-06. "ElectroCore wins cluster ... "Nerve Stimulator Approved for Cluster Headache". Pain News Network. Retrieved 2019-03-06. "Term Sheet -- Friday, June 22". ... headache FDA 510(k) indication for GammaCore". MassDevice. 2018-11-28. Retrieved 2019-03-06. " ...
Sewell RA (2008). "Unauthorized research on cluster headache" (PDF). The Entheogen Review. 16 (4): 117-125. Schultes RE (1941 ...
Ekbom, Karl (July 1974). "Migraine in Patients with Cluster Headache". Headache: The Journal of Head and Face Pain. 14 (2): 69- ... it may precede a migraine headache, but can also occur acephalgically (without headache), also known as visual migraine or ... It may occur as an isolated symptom without headache in acephalgic migraine. As the scotoma area expands, some people perceive ... Symptoms typically appear gradually over 5 to 20 minutes and generally last less than 60 minutes, leading to the headache in ...
Goadsby PJ, Edvinsson L (June 1994). "Human in vivo evidence for trigeminovascular activation in cluster headache. Neuropeptide ... Edvinsson L, Goadsby PJ (October 1994). "Neuropeptides in migraine and cluster headache". Cephalalgia. 14 (5): 320-7. doi: ... They have been proved to be effective in people who experience migraine headaches, both with and without aura, and both ... September 2017). "Blocking CGRP in migraine patients - a review of pros and cons". The Journal of Headache and Pain. 18 (1): 96 ...
... Cluster Headache Study Group (August 1991). "Treatment of acute cluster headache with sumatriptan". The New England ... is a medication used to treat migraine headaches and cluster headaches. It is taken orally, intranasally, or by subcutaneous ... The injectable form of the drug has been shown to abort a cluster headache within 30 minutes in 77% of cases. Sumatriptan is ... Sumatriptan is effective for ending or relieving the intensity of migraine and cluster headaches. It is most effective when ...
He also published work on cluster headache.[citation needed] Paul Robert Bing at Who Named It? v t e (Articles with short ...
Polgas faints from an intense cluster headache. Upon waking up, he discovers that he is in Dr. Dado Galang's clinic. The doctor ... Upon recovering from his headache, Polgas decides to explore Mount Arayat. He first calls the Thunderdog and instructs the ...
"What is cluster headache? Fact sheet for patients and their families. A publication to mark Cluster Headache Day 2016". ... Kudrow M.D., Lee (January 1981). "Response of Cluster Headache Attacks to Oxygen Inhalation". Headache. 21 (1): 1-4. doi: ... System for supply of breathing gas on demand within a confined space Oxygen for cluster headaches - Information for cluster ... DVOT is commonly used to treat conditions such as cluster headache, which affects up to four in 1000 people (0.4%), and is a ...
This includes herpes simplex infections; cluster headaches and migraine; and knee osteoarthritis. It was approved by the Health ... headache, cough and sneezing. Oral LD50 in mouse is >87.5 mg/kg in male and 90 mg/kg in males and >60 mg/kg in females. " ...
Research has also been conducted on psilocybin therapy for the treatment of migraines and cluster headaches. Given that most ... Sewell, RA; Halpern, JH; Pope HG, Jr (27 June 2006). "Response of cluster headache to psilocybin and LSD". Neurology. 66 (12): ... Dolan, Eric W. (2021-05-18). "A single dose of psilocybin has a lasting therapeutic effect on migraine headache, according to a ...
Minute amounts have been reported to stop cluster and migraine headaches. A double-blind study, done by Johns Hopkins Hospital ... Sewell RA, Halpern JH, Pope HG (2006). "Response of cluster headache to psilocybin and LSD". Neurology. 66 (12): 1920-22. doi: ...
Lambru G, Matharu M (April 2011). "Serotonergic agents in the management of cluster headache". Current Pain and Headache ... In the treatment of cluster headaches, methylergometrine has been initiated at a dose of 0.2 mg/day, rapidly increased to 0.2 ...
Sewell RA, Halpern JH, Pope HG (June 2006). "Response of cluster headache to psilocybin and LSD". Neurology. 66 (12): 1920-2. ... 1-Methylpsilocin has been investigated for applications such as treatment of glaucoma, OCD, and cluster headaches, as these ...
"Neurostimulation for Treatment of Migraine and Cluster Headache". Pain Medicine. 16 (9): 1827-1834. doi:10.1111/pme.12792. PMC ... headache and twitching in the scalp or upper face associated with the intervention. In addition, placebo manipulations can ...
Wheeler SD (July-August 1998). "Significance of migrainous features in cluster headache: divalproex responsiveness". Headache. ... Valproate is also used to prevent migraine headaches. The medication has been tested in the treatment of AIDS and cancer, owing ... It is also used to prevent migraine headaches. Valproate has a broad spectrum of anticonvulsant activity, although it is ... valproate semisodium forms are medications primarily used to treat epilepsy and bipolar disorder and prevent migraine headaches ...
Brauser D (April 18, 2017). "FDA Approves Vagus Nerve Stimulation Device for Cluster Headache". Medscape. "GammaCore Device ... for episodic cluster headaches, under the de novo pathway. In January 2018, the FDA cleared a new use of that device, for the ... Headache. 57 (4): 685-691. doi:10.1111/head.13069. PMID 28295242. S2CID 205161411. Cai PY, Bodhit A, Derequito R, Ansari S, ... Current Pain and Headache Reports. 19 (12): 54. doi:10.1007/s11916-015-0528-6. PMID 26493698. S2CID 8117776. Yesiltepe, Metin; ...
Jamieson suffers from episodic cluster headaches. BUFFY: the Songs of Buffy Sainte-Marie (2024) Trouble Sleeping (2021) Songs ...
The cause of cluster headache is unknown. Cluster headaches were historically described as vascular headaches, with the belief ... Trigeminal neuralgia is a unilateral headache syndrome, or "cluster-like" headache. Management for cluster headache is divided ... Cluster headaches are named for the occurrence of groups of headache attacks (clusters). They have also been referred to as " ... Cluster-like head pain may be diagnosed as secondary headache rather than cluster headache. A detailed oral history aids ...
... also known as histamine headache, is a primary neurovascular primary headache disorder, the pathophysiology and etiology of ... As the name suggests, CH involves a grouping of headaches, usually over a period of several weeks. ... encoded search term (Cluster Headache) and Cluster Headache What to Read Next on Medscape ... Tfelt-Hansen P. Acute pharmacotherapy of migraine, tension-type headache, and cluster headache. J Headache Pain. 2007 Apr. 8(2 ...
The largest study of patients with cluster headache to date suggests women have more severe attacks and longer headache bouts ... "This large study of rigorously diagnosed cluster headache patients mandates an elevated index of suspicion for cluster headache ... Women with cluster headache (CH) have more severe symptoms and longer headache bouts than men, and they are more likely to have ... "I have patients in our cohort and our clinic who say they go to neurologists with all the symptoms of cluster headache and the ...
... painful headaches for many days or even weeks in a row may signal that youre more likely to have other medical woes, ... who had cluster headaches. Most were men, because men are more likely to have cluster headaches. The researchers compared that ... of those who had cluster headaches had at least one additional illness and about 78% of those without cluster headaches had two ... These "cluster headaches" are extremely painful and can last from 15 minutes to three hours at a time. And people who have them ...
... such as chronic tension headaches, medication overuse headaches, cluster headaches, nerve pain (neuropathic pain), back pain ... such as chronic tension headaches, medication overuse headaches, cluster headaches, nerve pain (neuropathic pain), back pain ... We are looking for patients who suffer from cluster headaches and other rare primary headache disorders such as hemicrania ... Epidemiological data on cluster headaches indicate an increased risk of the disease in first-degree relatives. Familial cases ...
... researchers showed that galcanezumab significantly reduced weekly cluster headache attacks compared to placebo. ... The positive results in episodic cluster headache are truly a landmark moment-both for people living with cluster headache and ... The 2-month trial included 106 patients with episodic cluster headache with an average of 17.5 cluster headache attacks per ... reduction in weekly cluster headache attacks compared to placebo.. Cluster headache can be difficult to evaluate in clinical ...
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... April 24, 2019. SPT Staff ... Teva announced that it is discontinuing development of its drug fremanezumab (Ajovy) for the treatment of cluster headaches, ... was unlikely to meet the primary endpoint of mean change from baseline in the weekly average number of cluster headache attacks ... Teva continues to explore other uses for fremanezumab, including the treatment of post-traumatic headache, which is currently ...
Raising general awareness of cluster headache and offering support and guidance through our helpline and user forum ... About Cluster Headache. *Cluster Headache Basics. *What is Cluster Headache?. *Cluster Attack ...
Cluster headache due to internal carotid artery dissection. Author(s). S. S. M. Razvi, L. Walker, E. Teasdale, A. Tyagi, K. W. ...
Episodic cluster headache, Ictal phase, Inter-bout period, Plasma PACAP-38-LI. in Journal of Headache and Pain. volume. 17. ... Journal of Headache and Pain}}, title = {{Release of PACAP-38 in episodic cluster headache patients - An exploratory study}}, ... Release of PACAP-38 in episodic cluster headache patients - An exploratory study. *Mark ... Episodic cluster headache; Ictal phase; Inter-bout period; Plasma PACAP-38-LI}}, language = {{eng}}, number = {{1}}, publisher ...
Learn about the signs and symptoms of cluster headache including pain behind or around one eye. ... Cluster headache can be misdiagnosed as migraine disease. ... What is a cluster headache?. Cluster headache attacks occur in ... cluster headache is not a type of migraine and has its own set of signs and symptoms. Cluster headache is a primary headache ... Who gets cluster headache?. Men develop cluster headache more often than women. They generally develop between the ages of 20 ...
Cluster Headaches - Learn about the causes, symptoms, diagnosis & treatment from the MSD Manuals - Medical Consumer Version. ... What is a cluster headache? A cluster headache is a particular type of headache Overview of Headaches Headaches are one of the ... What causes a cluster headache? Doctors arent sure what causes a cluster headache. However, alcohol can trigger headaches ... These headaches happen in clusters, which means you get lots of headaches for a while and then no headaches for a while. ...
... and posture can all cause headaches during pregnancy. Learn more about the causes, symptoms, and treatments here. ... Cluster headaches Cluster headaches are rarer than other types, occurring in an estimated 0.3%. of all pregnancies. ... Tension headaches are the most common type of headache during pregnancy. In fact, a 2017 review in the Journal of Headache and ... of all headaches that occur during pregnancy are tension headaches. Tension headaches cause mild-to-moderate pain in the head. ...
A headache is pain or discomfort in your head, scalp, or neck. ... A headache is pain or discomfort in your head, scalp, or neck. ... What are the symptoms of a tension-type headache? A migraine headache? A cluster headache? ... National Headache Foundation website. The complete headache chart. headaches.org/resources/the-complete-headache-chart/. ... Tension-type headache - what to ask your doctor; Cluster headache - what to ask your doctor ...
Preventing Cluster Headache Attacks, Preventing Migraine Attacks, Preventing Tension Headache Attacks. ... Learn About Preventive Treatment for Primary Headache: Prevention of Risk Factors for Primary Headache, ... Preventive Treatment for Primary Headache: Preventing Cluster Headache, Tension Headache. *Difference between Tension Headache ... Classification and Types of Headache: Primary Headaches, Secondary Headaches. *Pathophysiology of Headache: Primary Headaches, ...
... also known as histamine headache, is a primary neurovascular primary headache disorder, the pathophysiology and etiology of ... As the name suggests, CH involves a grouping of headaches, usually over a period of several weeks. ... encoded search term (Cluster Headache) and Cluster Headache What to Read Next on Medscape ... Tfelt-Hansen P. Acute pharmacotherapy of migraine, tension-type headache, and cluster headache. J Headache Pain. 2007 Apr. 8(2 ...
Cluster Headaches. Cluster Headaches: Symptoms, Causes, and Treatments By Clarissa Vanner Your Health Cluster Headaches: ... Cluster headaches are extremely painful which is why its important to get informed. Lets take a closer look at what cluster ... Read More about Cluster Headaches: Symptoms, Causes, and Treatments 7 min read ... headaches are, how they differ from other types of headaches, and what to do to treat them if you ever experience one. ...
Managing Cluster Headaches Through the Seasons What is Cluster Headache? Cluster headache is often considered the most severe ... Waking Up with Headaches: Exploring 6 Types of Wake-Up Headaches Do you frequently wake up with a headache? This is a common ... One-Sided Headache with Congested Runny Nose: 5 Reasons Why Do you have a one-sided headache, left-sided headache, right-sided ... Choosing the Best Neuromodulation Devices for Migraine and Cluster Headaches There are 5 neuromodulation devices that are FDA ...
Melbourne osteopath Tim discusses what cluster headaches are and how treatment can help. ... Symptoms of Cluster Headaches vs. Migraine. *The non-painful symptoms tend to be slightly different. Migraine pain often ... Treatment For Cluster Headaches. It is very important to have an accurate diagnosis and treatment plan when working with ... People with cluster headaches usually have long periods of time between attacks in comparison to migraine. When an episode of ...
If you have Cluster Headaches, it can be difficult to convey the problem to a stranger. This card can help get your point ... If you have Cluster Headaches and cant communicate effectively, simply hand this card to a manager or employee... ... Its also a great tool to help others believe you might need a little more assistance as Cluster Headaches is hard to see... ...
Heres what may be causing your headache, and how to treat it. ... You can have headaches in different locations like behind the ... Cluster headaches. Youll typically feel cluster headaches behind or around your eye. They can also spread to your forehead, ... Cluster headache treatment. At home. Cluster headaches may be brought on by factors such as lifestyle, weather, or diet. ... Haaalp! Why Do I Have a Constant Headache?. Chronic daily headache is a persistent headache that happens at least 15 days out ...
What is a cluster headache? Learn more about the causes, symptoms, triggers, remedies, treatment, and prevention of tension ... What is a Cluster Headache?. A cluster headache is a type of headache that causes intense pain. It starts suddenly, usually on ... Cluster Headache vs Migraine. Cluster headache and migraines are both types of headaches, but with some key differences to ... Cluster Headache Symptoms. Cluster headache usually occurs on one side of the head. Besides this, symptoms of a cluster ...
The treatment of cluster headache is based on empirical data rather than on a pathophysiological concept of this disorder.6 ... of cluster headache patients still have attacks.5. Treatment of Cluster Headache. The treatment of cluster headache is based on ... The most important and prevalent of these headache disorders is cluster headache.. Cluster headache is defined as a paroxysmal ... Cluster headache is a rare but extremely disabling condition. For the acute treatment of cluster headache attacks, oxygen (100 ...
... (Histamine Headache): Read more about Symptoms, Diagnosis, Treatment, Complications, Causes and Prognosis. ... characterized by recurrent severe headaches particularly on one side of the head. It is a neurological disorder, wherein the ... Facts about Cluster Headaches Cluster headaches last a short period of time, but cause severe pain Men suffer from cluster ... Recurrent headache occurred in 4.4% of the cases: migraine in 1.7%; cluster headache in 0.09%; other, non‐migrainous headache ( ...
Muxima are displaying a Cluster Headache Awareness Exhibition, When the Beast Knocks by Mister Geez from 23 - 30 March. ... A percentage of sales will go to the OUCH charity (Organisation for the Understanding of Cluster Headache). ... Muxima is excited to announce the Cluster Headache Awareness Exhibition from Wednesday 23 - Wednesday 30 March 2022. ...
Global Cluster Headache Market is anticipated to reach a value of over USD xx billion by 2028 and register a CAGR of xx% for ... Cluster Headache Market # Cluster Headache Market Size # Cluster Headache Market Share # Cluster Headache Market Trends ... Global Cluster Headache Market is anticipated to reach a value of over USD xx billion by 2028 and register a CAGR of xx% for ... Global Cluster Headache Market is anticipated to reach a value of over USD xx billion by 2028 and register a CAGR of xx% for ...
By Rosie,2021-11-15T07:26:27+00:00October 25th, 2021,Back Pain, Chiropractic for Seniors, Headaches, Hip and Joint Pain, Neck ... Back Pain, Chiropractic for Seniors, Headaches, Hip and Joint Pain, Neck Pain, Pain, Pregnancy and Chiropractic, Sciatica, ...
Symptoms cluster headache: Cluster headache affects only 2 percent of the population and is characterized by half-sided ... Cluster or tension headache - Why is the head buzzing? Health Some 72 percent of the population occasionally suffer from ... sweating and tension of the cervical spine on the side of the headache. In cluster headache, attacks typically repeat several ... Symptoms tension headache: Typically, tension-type headaches occur bilaterally and are considered to be dull, oppressive, ...
Do you often experience headache attacks back to back These are called cluster headaches and can cause great disruption and ... you may be dealing with cluster headaches.. What are Cluster Headaches?. Cluster headaches are recurring headaches that may ... How Often do Cluster Headaches Occur?. The frequency of cluster headaches may vary. The clusters may hit for only a week or may ... How are Cluster Headaches Treated?. Unless you plan on waiting until the cluster headaches pass, you should go to the doctor ...
  • The pain is typically greater than in other headache conditions, including migraines, and is usually described as burning, stabbing, drilling or squeezing. (wikipedia.org)
  • Migraines A migraine isn't just a bad headache. (msdmanuals.com)
  • Cluster headache and migraines are both types of headaches, but with some key differences to distinguish between the two. (homage.sg)
  • 92 percent of those affected are affected by tension headaches and migraines. (newwomensmag.com)
  • A doctor can inject the sufferer with drugs called triptans, which ease both cluster headaches and migraines, or with a synthetic hormone called octreotide. (mywilliamsonchiro.com)
  • Attacks often occur in clusters which typically last for weeks or months and occasionally more than a year. (wikipedia.org)
  • Cluster headaches are named for the occurrence of groups of headache attacks (clusters). (wikipedia.org)
  • Cluster headaches are recurring bouts of severe unilateral headache attacks. (wikipedia.org)
  • Women were significantly more likely than men to have headache bouts lasting 4 months or longer and were more likely to have attacks that followed a circadian pattern, with early-morning onset. (medscape.com)
  • Despite the challenges of studying the condition, researchers showed that galcanezumab significantly reduced weekly cluster headache attacks compared to placebo. (hcplive.com)
  • Eli Lilly and Company's galcanezumab reached the primary endpoint in an episodic cluster headache trial, achieving statistically significant differences in the reduction of weekly cluster headache attacks compared to placebo across weeks 1 to 3 of the 2-month treatment period. (hcplive.com)
  • The drug also met its secondary endpoint, with a statistically significantly greater percentage of treated patients reaching at least a 50% reduction in weekly cluster headache attacks compared to placebo. (hcplive.com)
  • The 2-month trial included 106 patients with episodic cluster headache with an average of 17.5 cluster headache attacks per week at baseline. (hcplive.com)
  • The patients treated with galcanezumab experienced statistically significant differences in the reduction of weekly cluster headache attacks compared to patients treated with placebo during the first 3 weeks of the study (-8.7 for galcanezumab compared to -5.2 for placebo, p=0.036). (hcplive.com)
  • According to a press release , an analysis of a phase 3 study found that the treatment was unlikely to meet the primary endpoint of mean change from baseline in the weekly average number of cluster headache attacks during the 4-week period. (pharmacytimes.com)
  • Cluster headache attacks occur in episodes. (migraine.com)
  • When these attacks end, people with cluster feel exhausted but without ongoing symptoms. (migraine.com)
  • Yet, once a cluster headache comes on, many people refrain from drinking alcohol as this can make some cluster headache attacks worse. (migraine.com)
  • Attacks of Headache- Attacks are usually short, lasting from 15 to 180 minutes, and the excruciating pain may have subsided by the time a patient reaches a doctor's office or emergency room. (epainassist.com)
  • Treatment efforts focus on the prevention of attacks during cluster or migraine cycles. (epainassist.com)
  • People with cluster headaches usually have long periods of time between attacks in comparison to migraine. (flowosteopathy.com.au)
  • When an episode of cluster headaches begins, the attacks are often a string of intense, frequent bouts of pain (1-8 per day). (flowosteopathy.com.au)
  • For the acute treatment of cluster headache attacks, oxygen (100%) with a flow of at least 7l/minute, 6mg subcutaneous sumatriptan, and 5mg zolmitriptan nasal spray are the drugs of first choice. (touchneurology.com)
  • 1 All of these headache syndromes have two features in common: relatively short-lasting, unilateral, severe headache attacks, and, typically, accompanying cranial autonomic symptoms. (touchneurology.com)
  • If the cluster attacks occur for longer than one year without remission periods or with remission periods lasting for less than one month, the diagnosis is chronic cluster headache. (touchneurology.com)
  • after 15 years, 80% of cluster headache patients still have attacks. (touchneurology.com)
  • This headache syndrome involves what is described as "attacks" of severe pain on one side of the head lasting 15-180 minutes and occurring as little as once every day or as often as 8 times a day. (symptoma.com)
  • The headaches can also be seasonal, with the spring or fall signaling the onset of attacks. (symptoma.com)
  • The trigeminal nerve also stimulates the parasympathetic autonomic system, which causes the eye tearing and redness, nasal congestion and discharge with cluster attacks. (symptoma.com)
  • In cluster headache, attacks typically repeat several times a day and have a rapid increase in pain intensity. (newwomensmag.com)
  • Let's take a closer look at what cluster headaches are, how they differ from other types of headaches, and what to do to treat them if you ever experience one. (activebeat.com)
  • Vicks Vaporub has been found to be helpful in treating various types of headaches, including sinus headaches, tension headaches, and migraine headaches. (websites-general-directory.org)
  • Women were also more likely to have a co-occurring migraine or tension-type headache and to have an immediate family member who had a history of CH. (medscape.com)
  • but some are caused by a serious problem Tension headaches. (msdmanuals.com)
  • Together, these changes may make certain types of headache, such as tension headaches, more likely. (medicalnewstoday.com)
  • However, some women continue to experience tension headaches from hormonal changes throughout their pregnancy. (medicalnewstoday.com)
  • Tension headaches are the most common type of headache during pregnancy. (medicalnewstoday.com)
  • In fact, a 2017 review in the Journal of Headache and Pain notes that 26% of all headaches that occur during pregnancy are tension headaches. (medicalnewstoday.com)
  • Tension headaches cause mild-to-moderate pain in the head. (medicalnewstoday.com)
  • Acute headache should be evaluated in young and middle age female patients to rule out life threatening causes of tension headache . (epainassist.com)
  • Tfelt-Hansen P. Acute pharmacotherapy of migraine, tension-type headache, and cluster headache. (medscape.com)
  • Cluster or tension headache - Why is the head buzzing? (newwomensmag.com)
  • Typically, tension-type headaches occur bilaterally and are considered to be dull, oppressive, pulling from the neck to the forehead, not pulsating. (newwomensmag.com)
  • Possible causes of tension-type headache are: stress situations, muscle tension, especially due to prolonged sitting, weather changes, depression, poorly ventilated rooms or drug abuse. (newwomensmag.com)
  • The duration can be between 15 minutes to 3 hours and be diagnosed by the following side effects: reddened conjunctiva, burning and watery eyes, sweating and tension of the cervical spine on the side of the headache. (newwomensmag.com)
  • The use of Vicks Vaporub for cluster headaches, sinus headaches, tension headaches, and migraine headaches has been reported by individuals seeking relief from their symptoms. (websites-general-directory.org)
  • Tension headaches are a common type of headache caused by muscle contractions in the head and neck region. (websites-general-directory.org)
  • Using Vicks Vaporub for tension headaches involves applying the product topically to the temples and forehead. (websites-general-directory.org)
  • There are also alternative treatments for tension headaches, including massage, relaxation techniques, and lifestyle changes such as getting enough sleep and exercise. (websites-general-directory.org)
  • If your tension headaches persist or become more severe, it is important to seek medical attention to rule out any underlying conditions. (websites-general-directory.org)
  • She received a diagnosis of chronic tension headache about 10 years ago. (medscape.com)
  • She describes a sharp pain with an electric-shock sensation, in contrast to the dull ache of her tension headaches. (medscape.com)
  • Worldwide, the percentages of the adult population with an active headache disorder are 46% for headache in general, 11% for migraine (MIG), 42% for tension-type headache (TTH) and 3% for chronic daily headache. (medscape.com)
  • This guideline covers advice on the diagnosis and management of tension-type headache, migraine (including migraine with aura and menstrual-related migraine), cluster headache and medication overuse headache in young people (aged 12 years and older) and adults. (bvsalud.org)
  • Cluster headache (CH) is a neurological disorder characterized by recurrent severe headaches on one side of the head, typically around the eye(s). (wikipedia.org)
  • Cluster headache is a condition, characterized by recurrent severe headaches particularly on one side of the head. (symptoma.com)
  • Migraine is a complex disorder characterized by recurrent episodes of headache, most often unilateral and in some cases associated with visual or sensory symptoms-collectively known as an aura-that arise most often before the head pain but that may occur during or afterward (see the image below). (medscape.com)
  • Though CH is strictly unilateral, there are some documented cases of "side-shift" between cluster periods, or, rarely, simultaneous (within the same cluster period) bilateral cluster headaches. (wikipedia.org)
  • The typical symptoms of cluster headache include grouped occurrence and recurrence (cluster) of headache attack, severe unilateral orbital, supraorbital and/or temporal pain. (wikipedia.org)
  • Cluster headache is defined as a paroxysmal, strongly unilateral, very severe headache, typically with a retro-orbital maximum of pain. (touchneurology.com)
  • Development of severe, unilateral and sudden headache marks the onset of cluster headaches. (symptoma.com)
  • Some people may experience the nausea and auras generally attributable to migraine before the pain from the cluster headache, which comes on rapidly. (migraine.com)
  • What can I do about nausea or vomiting with my headaches? (medlineplus.gov)
  • Nausea precedes headache. (epainassist.com)
  • Migraine headaches are a severe form of headache that can cause intense pain, nausea, and sensitivity to light and sound. (websites-general-directory.org)
  • Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition. (medscape.com)
  • People who have cluster headaches may be more than three times more likely to have other medical conditions, such as heart disease or mental disorders, the new study found. (upi.com)
  • Scientists at the Kiel Pain Clinic and the Hamburg University Hospital are investigating which molecular genetic factors play a role in the development of cluster headaches and other rare primary headache disorders. (schmerzklinik.de)
  • We are looking for patients who suffer from cluster headaches and other rare primary headache disorders such as hemicrania continua, chronic paroxysmal hemicrania, SUNCT, etc. (schmerzklinik.de)
  • Familial cases of the very rare primary headache disorders have also been reported. (schmerzklinik.de)
  • B. in cystic fibrosis or Huntington's chorea, in each of which a single gene is changed, several genetic factors are involved in the development of primary headache disorders. (schmerzklinik.de)
  • The doctors and scientists at the Kiel Pain Clinic and the Hamburg Institute for Human Genetics want to examine several hundred patients who suffer from cluster headaches and other rare primary headache disorders. (schmerzklinik.de)
  • Our goal is to use genetic analyzes to investigate the molecular mechanisms underlying the rare primary headache disorders as comprehensively as possible. (schmerzklinik.de)
  • The International Classification of Headache Disorders: 2nd edition. (medscape.com)
  • Optimum treatment for all primary headache disorders is holistic and patient-centered. (flowosteopathy.com.au)
  • The most important and prevalent of these headache disorders is cluster headache. (touchneurology.com)
  • Currently, lithium is used to treat a variety of disorders including cluster headaches, alcoholism, and Grave's disease. (cdc.gov)
  • In the following systematic review, we address the literature on headache and pituitary disorders with regard to prevalence, aetiology, pathophysiological mechanisms and treatment. (medscape.com)
  • Cluster headache is often considered the most severe type of headache experienced by headache sufferers. (virtualheadachespecialist.com)
  • This type of headache can be brought on by intense physical activities, causing that throbbing sensation. (greatist.com)
  • A cluster headache is a type of headache that causes intense pain. (homage.sg)
  • The duration of this type of headache can last from 30 minutes to 5-6 days and occasionally occur daily. (newwomensmag.com)
  • In women, this type of headache is much more common than in men. (newwomensmag.com)
  • More research is needed to determine its effectiveness in treating this type of headache. (websites-general-directory.org)
  • 1 Head pain during the cluster period occur daily, even multiple times a day. (migraine.com)
  • Primary headaches are not a symptom of a health condition, whereas secondary headaches occur when an underlying condition is the cause. (medicalnewstoday.com)
  • Migraine headaches may also occur during pregnancy. (medicalnewstoday.com)
  • According to estimates, migraine headaches without aura occur in up to 10% of pregnant women. (medicalnewstoday.com)
  • This classification of cluster headache occur regularly for longer than a year, and are followed by a headache-free period of less than a month. (homage.sg)
  • These autonomic symptoms occur on the side of the headache and comprise lacrimation, conjunctival injection, rhinorrhea, miosis, and ptosis. (touchneurology.com)
  • Headaches typically occur at the same time of the day, every day and last for about 15 to 180 minutes. (symptoma.com)
  • For example, cluster periods can occur seasonally, such as every spring or every fall . (symptoma.com)
  • The pain of the headaches is often intense and may occur on one side of your head or near one of your eyes. (physicianpartnersofamerica.com)
  • How Often do Cluster Headaches Occur? (physicianpartnersofamerica.com)
  • Cluster headaches get their name because they occur in a cyclical pattern. (mywilliamsonchiro.com)
  • They are a primary headache disorder of the trigeminal autonomic cephalalgias type. (wikipedia.org)
  • Cluster headache attack is accompanied by at least one of the following autonomic symptoms: drooping eyelid, pupil constriction, redness of the conjunctiva, tearing, runny nose and less commonly, facial blushing, swelling, or sweating, typically appearing on the same side of the head as the pain. (wikipedia.org)
  • Pathophysiology of cluster headache: a trigeminal autonomic cephalgia. (medscape.com)
  • Trigemino-autonomic headaches are characterized by very severe and unbearable headaches, accompanied by symptoms of the autonomic nervous system in the head area such as conjunctival injection (redness of the conjunctiva), lacrimation (watery eyes), nasal congestion and/or rhinorrhea (congestion and/or runny nose), increased sweating in the forehead and face area, miosis (constricted pupil), ptosis (drooping eyelid), eyelid edema and skin changes. (schmerzklinik.de)
  • Cluster headache is a primary headache disorder and is a part of the trigeminal autonomic cephalgias (TAC) group. (migraine.com)
  • 1,2 This means they develop on one side of the head in the trigeminal nerve area and symptoms that develop are in the autonomic controlled systems on the same side of the head as the headache. (migraine.com)
  • The second edition of the headache classification from the International Headache Society (IHS) has defined a new primary headache grouping named the trigemino-autonomic cephalgias (TAC). (touchneurology.com)
  • James Martinez, MD, Lilly medical fellow and study author, elaborated further, saying that patients with this condition experience headaches that are "excruciatingly severe. (hcplive.com)
  • Research suggests that 39% of women will experience headaches during or just after pregnancy. (medicalnewstoday.com)
  • In the second and third trimesters, a woman may be less likely to experience headaches due to hormonal changes, as the body has usually adjusted to these changes by this stage of pregnancy. (medicalnewstoday.com)
  • Individuals usually experience headaches 2 to 3 hours after they fall asleep. (symptoma.com)
  • During a period of cluster headaches, the sufferer usually gets at least one headache per day, lasting between 15 minutes and three hours. (mywilliamsonchiro.com)
  • 61-Year-Old With Irritability, Headaches, and Weight Loss - Medscape - Nov 13, 2023. (medscape.com)
  • Guideline] Biondi D, Mendes P. Treatment of primary headache: cluster headache. (medscape.com)
  • The manufacturer, Eli Lilly, previously conducted a phase 3 trial of galcanezumab for patients with chronic cluster headache that did not meet its primary endpoint. (hcplive.com)
  • Medically speaking, headaches are either primary or secondary. (medicalnewstoday.com)
  • The focus of treatment at that time was to treat primary headache when pain become intolerable instead of preventing occurrence of primary headache. (epainassist.com)
  • Early prevention and treatment may discontinue occurrence or frequency of primary headache. (epainassist.com)
  • Primary headaches. (greatist.com)
  • However, any predisposition of a patient for primary headache will also contribute significantly to the development of headache in conjunction with pituitary disease. (medscape.com)
  • The pain can be so intense that people experiencing cluster headache are likely to rock back and forth or pace to try and block it out. (migraine.com)
  • Cluster headaches normally come on suddenly, and are marked by a burst of intense pain as it starts. (homage.sg)
  • If you get intense headaches that seem to come in a pattern, you may be dealing with cluster headaches. (physicianpartnersofamerica.com)
  • Because cluster headaches are so intense, the afflicted may feel desperate. (mywilliamsonchiro.com)
  • Our results show that people with cluster headaches not only have an increased risk of other illnesses, those with at least one additional illness missed four times as many days of work due to sickness and disability than those with just cluster headaches. (upi.com)
  • People with cluster headaches missed an average number of 63 days of work due to sickness and disability compared to 34 days in those without cluster headaches, the findings showed. (upi.com)
  • Increasing our understanding of the other conditions that affect people with cluster headache and how they impact their ability to work is very important," Ran said in a journal news release. (upi.com)
  • Several medications help people with cluster headaches. (mywilliamsonchiro.com)
  • For long-term treatment of chronic cluster headaches, lithium may be used as an alternative to verapamil. (epainassist.com)
  • Ekbom K, Ahlborg B, Schéle R. Prevalence of migraine and cluster headache in Swedish men of 18. (medscape.com)
  • The positive results in episodic cluster headache are truly a landmark moment-both for people living with cluster headache and for our researchers at Lilly, many of whom have spent more than two decades researching and developing innovative, non-opioid treatment options for diseases like migraine and cluster headache,' said Shaw. (hcplive.com)
  • Cluster headache: from treatment to pathophysiology. (bvsalud.org)
  • Unlike acute headache treatments, which are taken at the onset of each headache, researchers administered galcanezumab subcutaneously on a monthly basis during the trial. (hcplive.com)
  • Preventative treatments] try to reduce the overall number of headaches. (hcplive.com)
  • Women with cluster headache (CH) have more severe symptoms and longer headache bouts than men, and they are more likely to have a chronic subtype of the disorder, new research shows. (medscape.com)
  • The episodic form of cluster headache occurs in 80% of cluster headache sufferers, with bouts lasting for between seven and 365 days separated by pain-free remission periods of longer than one month's duration. (touchneurology.com)
  • This is the case in 15-20% of cluster headache sufferers. (touchneurology.com)
  • They are also called "suicide headaches," because they can drive sufferers to despair. (mywilliamsonchiro.com)
  • Some sufferers have predictable cluster headaches, which present at the same time every day, or even during a certain season. (mywilliamsonchiro.com)
  • However, alcohol can trigger headaches during a cluster period. (msdmanuals.com)
  • Will alcohol or smoking make my headaches worse? (medlineplus.gov)
  • In: Standards of care for headache diagnosis and treatment. (medscape.com)
  • Diagnosis and Treatment of Headache. (medscape.com)
  • It is very important to have an accurate diagnosis and treatment plan when working with cluster headaches. (flowosteopathy.com.au)
  • There are also certain medications that may trigger cluster headache including nitroglycerine, taken for heart problems. (migraine.com)
  • Additionally, a pregnant woman may have some trigger foods that cause irritation or symptoms such as headaches. (medicalnewstoday.com)
  • When you cut out caffeine, you're withdrawing it from your routine, which can change your brain chemistry and trigger a headache. (greatist.com)
  • While sometimes confused with migraine disease, cluster headache is not a type of migraine and has its own set of signs and symptoms. (migraine.com)
  • It is a difficult headache disorder to study, so we were pleased to conduct the study and demonstrate efficacy," said Martinez. (hcplive.com)
  • The treatment of cluster headache is based on empirical data rather than on a pathophysiological concept of this disorder. (touchneurology.com)
  • Patients with poorly defined nocturnal or awakening headaches should undergo polysomnography to exclude a treatable sleep disturbance, especially in the absence of an underlying psychological disorder or analgesic overuse syndrome. (symptoma.com)
  • Men are likelier victims than women, and usually develop this headache disorder between the age of 20 and 50. (mywilliamsonchiro.com)
  • Headache is a very common disorder. (medscape.com)
  • Clinical policy: critical issues in the evaluation and management of adult patients presenting to the emergency department with acute headache. (medscape.com)
  • Acute headache could be secondary to serious problem within the skull, which needs immediate investigation and treatment. (epainassist.com)
  • 5-7 During the acute phase, symptoms are generally limited to a febrile illness with associated headaches, fatigue and chills. (who.int)
  • Female cluster headache in the United States of America: what are the gender differences? (medscape.com)
  • It is important to note that the use of Vicks Vaporub for headaches is not a medically recognized treatment option, and individuals should consult with a healthcare professional before using Vicks Vaporub or any other non-prescription medication for headaches. (websites-general-directory.org)
  • On the other hand, cluster headaches will present with one or more of: watery eyes, a runny nose, drooping eyelid, swelling in the eyelid or forehead sweating. (flowosteopathy.com.au)
  • According to the World Health Organization, headaches are a global problem, affecting people of all races, income levels, and regional areas. (virtualheadachespecialist.com)
  • The World Health Organization reports that 1 out of every 20 people around the globe get headaches almost every day. (greatist.com)
  • Muxima is excited to announce the Cluster Headache Awareness Exhibition from Wednesday 23 - Wednesday 30 March 2022. (romanroadlondon.com)
  • Global Cluster Headache Market is anticipated to reach a value of over USD xx billion by 2028 and register a CAGR of xx% for the forecast period 2022-2028. (meetupss.com)
  • During March-July 2022, Michigan public health officials identified a cluster of ocular syphilis cases. (cdc.gov)
  • Women with migraine typically report headaches before or during their period. (greatist.com)
  • Study CGAL: A phase 3 placebo-controlled study of galcanezumab in patients with episodic cluster headache: Results from the 8-week double-blind treatment phase (abstract IOR03LB). (medscape.com)
  • The study, which is the largest to date involving patients with cluster headache (CH), adds to a growing body of work that suggests an illness that affects mostly men may actually have a much greater effect on women. (medscape.com)
  • I have patients in our cohort and our clinic who say they go to neurologists with all the symptoms of cluster headache and the neurologists say that 'you can't have cluster headache because you're a woman,' " Belin said. (medscape.com)
  • This large study of rigorously diagnosed cluster headache patients mandates an elevated index of suspicion for cluster headache in women, and an awareness of possibly more burdensome disease in women," the editorialists add. (medscape.com)
  • About 60% of all cluster headache patients respond to this treatment with significant pain reduction within 30 minutes. (touchneurology.com)
  • In placebo-controlled trials, sumatriptan injected subcutaneously was effective in about 75% of all cluster headache patients (i.e. they were pain-free within 20 minutes). (touchneurology.com)
  • Headache is very common in pituitary disease and is reported to be present in more than a third of all patients with pituitary adenomas. (medscape.com)
  • Some studies suggest that oversecretion of GH and prolactin may be important for the development of headaches, and treatment, particularly with somatostatin analogues, has been shown to improve symptoms in these patients. (medscape.com)
  • MDHHS and KCHCSD, which includes a sexual health clinic with comprehensive testing, treatment, and counseling services, coordinated response and investigation of the patients in the cluster. (cdc.gov)
  • Neuroimaging is not necessary in patients with a history of recurrent migraine headaches and a normal neurologic examination. (medscape.com)
  • Don't perform neuroimaging studies in patients with stable headaches that meet criteria for migraine. (medscape.com)
  • Cluster headache can be difficult to evaluate in clinical studies, which has contributed to few available treatment options for cluster headache, often considered the most severe pain one can experience,' said Christi Shaw, president of Lilly Bio-Medicines in a statement . (hcplive.com)
  • Cluster periods can last a year or longer. (migraine.com)
  • They usually stop quickly, and are followed by headache-free periods, before the next headache starts again. (homage.sg)
  • The cluster of headaches may last for weeks or months, with remission periods in between. (mywilliamsonchiro.com)
  • The present review attempts to systematically review the literature for any combination of headache and pituitary or hormone overproduction or deficiency. (medscape.com)
  • Whereas in pituitary apoplexy a mechanical component explains the almost universal association of the condition with headaches, this correlation is less clear in other forms of pituitary disease and a positive impact of surgery on headaches is not guaranteed. (medscape.com)
  • [ 1 ] Headaches are frequently linked to pituitary disease, and it is generally accepted that headache is a common presenting feature of pituitary adenomas and other sellar pathologies. (medscape.com)
  • All articles reporting original data and review articles on headache and pituitary disease in peer reviewed journals were screened for inclusion into the present review. (medscape.com)
  • A misaligned cervical vertebra can put pressure on the trigeminal nerve, which carries pain signals during a cluster headache. (mywilliamsonchiro.com)
  • Your estrogen levels rise during pregnancy, and those hormonal changes can lead to headaches and migraine. (greatist.com)
  • Most data available are retrospective and/or not based on the International Headache Society (IHS) classification. (medscape.com)
  • Otherwise, treatment rests on general treatment options for headaches based on an accurate clinical history and a precise classification which includes assessment of the patient's psychosocial risk factors. (medscape.com)
  • We also provide a brief overview of the general classification of headaches. (medscape.com)
  • We're very interested in learning more about the treatment response in men and women and why chronic cluster headache seems to be more common in women," Belin said. (medscape.com)
  • Overview of Headaches Headaches are one of the most common reasons people go to the doctor. (msdmanuals.com)
  • Experiencing a headache during pregnancy is common and not usually a cause for concern. (medicalnewstoday.com)
  • Headaches are a common symptom during pregnancy. (medicalnewstoday.com)
  • A common symptom of preeclampsia is a headache that will not go away. (medicalnewstoday.com)
  • The sections below will discuss several types of headache that are common during pregnancy. (medicalnewstoday.com)
  • Headaches are more common in adult female population. (epainassist.com)
  • Although migraine is far more common than cluster headache, there are some clear distinguishing factors. (flowosteopathy.com.au)
  • Severe, uncontrolled high blood pressure , often called malignant hypertension, can contribute to headaches, although high blood pressure is not a common cause of headaches. (greatist.com)
  • On the other hand, low blood pressure (aka hypotension) from common problems such as dehydration or even blood loss due to menstruation can commonly cause headaches and lightheadedness. (greatist.com)
  • Headaches are a common ailment, but they can be quite debilitating. (physicianpartnersofamerica.com)
  • A cluster of five cases of ocular syphilis in women with a common male sex partner was identified in Michigan, suggesting that an unidentified Treponema pallidum strain might have been a risk factor for developing systemic manifestations of syphilis. (cdc.gov)
  • A common heterosexual partner in an ocular syphilis cluster has not been previously documented and suggests that an unidentified strain of T. pallidum might have been associated with increased risk for systemic manifestations of syphilis. (cdc.gov)
  • Dr. Peter Goadsby, Professor of Clinical Neurology at University College London, a leading researcher on the condition has commented: "Cluster headache is probably the worst pain that humans experience. (wikipedia.org)
  • Curr Pain Headache Rep . 2009 Apr. (medscape.com)
  • When the cluster period ends head pain may not reappear for months or even up to a year. (migraine.com)
  • It is important to contact your doctor if you think you have developed cluster headache or experience a significant change in the pain or pattern of headaches. (migraine.com)
  • A headache is pain or discomfort in your head, scalp, or neck. (medlineplus.gov)
  • What are the pain medicines that can be used for headaches? (medlineplus.gov)
  • Will taking too many pain medicines make my headaches worse? (medlineplus.gov)
  • Headaches and other head pain. (medlineplus.gov)
  • Headache and other craniofacial pain. (medlineplus.gov)
  • Migraine or cluster headaches are severe irritating pain, which often are intolerable. (epainassist.com)
  • Headache associated with eye pain and diplopia . (epainassist.com)
  • But the location of your headache can actually help tip you off to the cause of that persistent and annoying pain. (greatist.com)
  • What's the cause of your headache pain? (greatist.com)
  • The headache reaches its peak in five to 10 minutes, and is described as a constant and deep, burning, and piercing type of pain. (homage.sg)
  • It can also be used to alleviate cough headaches and neck pain headaches. (websites-general-directory.org)
  • Though the exact cause of cluster headaches is unknown, the nerves near your eye are believed to be a factor. (physicianpartnersofamerica.com)
  • Researchers do not know the cause of cluster headaches, but suspect it could be linked to an abnormality in the hypothalamus. (mywilliamsonchiro.com)
  • Having short, painful headaches for many days or even weeks in a row may signal that you're more likely to have other medical woes, researchers say. (upi.com)
  • These "cluster headaches" are extremely painful and can last from 15 minutes to three hours at a time. (upi.com)
  • Cluster headaches are extremely painful which is why it's important to get informed. (activebeat.com)
  • Like a Pencil in Your Eyeball Cluster headaches are both rare and uncommonly painful. (symptoma.com)
  • The headaches she has been experiencing recently, however, are much more painful than her usual headaches. (medscape.com)
  • Stochino ME, Deidda A, Asuni C, Cherchi A, Manchia M, Del Zompo M. Evaluation of lithium response in episodic cluster headache: a retrospective case series. (medscape.com)
  • Cluster headache prevalence in the Italian general population. (medscape.com)
  • Cluster headache prevalence. (medscape.com)
  • The lifetime prevalence of cluster headache is about 0.1%, with a mean male-to-female ratio of 4.3:1. (touchneurology.com)
  • Increased prevalence of sensing types in men with cluster headaches. (bvsalud.org)
  • Although they are not approved for cluster headache, anti-seizure drugs such as valproate (Depakote), topiramate (Topamax), and gabapentin (Neurontin), are sometimes used for preventive treatment. (epainassist.com)
  • Teva announced that it is discontinuing development of its drug fremanezumab (Ajovy) for the treatment of cluster headaches, the company reported. (pharmacytimes.com)
  • Treatment of cluster headache in pregnancy and lactation. (medscape.com)
  • Similarly, invasion into the cavernous sinus or local inflammatory changes have been linked to headaches without convincing evidence. (medscape.com)
  • I know that's quite a strong remark to make, but if you ask a cluster headache patient if they've had a worse experience, they'll universally say they haven't. (wikipedia.org)
  • Women with cluster headache will tell you that an attack is worse than giving birth. (wikipedia.org)
  • Some other pregnancy symptoms may also influence these headaches or make them worse. (medicalnewstoday.com)
  • Are there foods that I should stay away from that may make my headaches worse? (medlineplus.gov)
  • Patient may have to try several medications to find out the most effective medication to prevent recurrence of headache. (epainassist.com)
  • It's also part of headache medications like Excedrin . (greatist.com)
  • Some medications used to treat hypertension can cause headaches as a side effect, but not because of their effects on blood pressure. (greatist.com)
  • Unlike some headache medications, it does not involve ingesting anything, making it a good choice for those who prefer natural remedies or are sensitive to certain drugs. (websites-general-directory.org)
  • These headaches can be mild to moderate in severity and can be treated with various over-the-counter medications, including Vicks Vaporub. (websites-general-directory.org)