Clotrimazole: An imidazole derivative with a broad spectrum of antimycotic activity. It inhibits biosynthesis of the sterol ergostol, an important component of fungal CELL MEMBRANES. Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane.Miconazole: An imidazole antifungal agent that is used topically and by intravenous infusion.Econazole: An imidazole derivative that is commonly used as a topical antifungal agent.Candidiasis, Vulvovaginal: Infection of the VULVA and VAGINA with a fungus of the genus CANDIDA.Antifungal Agents: Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues.Griseofulvin: An antifungal agent used in the treatment of TINEA infections.Ketoconazole: Broad spectrum antifungal agent used for long periods at high doses, especially in immunosuppressed patients.Intermediate-Conductance Calcium-Activated Potassium Channels: A major class of calcium-activated potassium channels that were originally discovered in ERYTHROCYTES. They are found primarily in non-excitable CELLS and set up electrical gradients for PASSIVE ION TRANSPORT.Imidazoles: Compounds containing 1,3-diazole, a five membered aromatic ring containing two nitrogen atoms separated by one of the carbons. Chemically reduced ones include IMIDAZOLINES and IMIDAZOLIDINES. Distinguish from 1,2-diazole (PYRAZOLES).Trichophyton: A mitosporic fungal genus and an anamorphic form of Arthroderma. Various species attack the skin, nails, and hair.Balanitis: Inflammation of the head of the PENIS, glans penis.Benzene DerivativesTinea Pedis: Dermatological pruritic lesion in the feet, caused by Trichophyton rubrum, T. mentagrophytes, or Epidermophyton floccosum.Surgical Tape: A flat, flexible strip of material used to cover or fasten together damaged tissue.Skin Cream: A water-soluble medicinal preparation applied to the skin.Epidermophyton: A fungal genus which grows in the epidermis and is the cause of TINEA.Candida albicans: A unicellular budding fungus which is the principal pathogenic species causing CANDIDIASIS (moniliasis).Proadifen: An inhibitor of drug metabolism and CYTOCHROME P-450 ENZYME SYSTEM activity.Azoles: Five membered rings containing a NITROGEN atom.Tinea: Fungal infection of keratinized tissues such as hair, skin and nails. The main causative fungi include MICROSPORUM; TRICHOPHYTON; and EPIDERMOPHYTON.Pessaries: Devices worn in the vagina to provide support to displaced uterus or rectum. Pessaries are used in conditions such as UTERINE PROLAPSE; CYSTOCELE; or RECTOCELE.Cytochrome P-450 Enzyme System: A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.Vulvovaginitis: Inflammation of the VULVA and the VAGINA, characterized by discharge, burning, and PRURITUS.Suppositories: Medicated dosage forms that are designed to be inserted into the rectal, vaginal, or urethral orifice of the body for absorption. Generally, the active ingredients are packaged in dosage forms containing fatty bases such as cocoa butter, hydrogenated oil, or glycerogelatin that are solid at room temperature but melt or dissolve at body temperature.Candidiasis, Oral: Infection of the mucous membranes of the mouth by a fungus of the genus CANDIDA. (Dorland, 27th ed)Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Ointment Bases: Various mixtures of fats, waxes, animal and plant oils and solid and liquid hydrocarbons; vehicles for medicinal substances intended for external application; there are four classes: hydrocarbon base, absorption base, water-removable base and water-soluble base; several are also emollients.Candidiasis: Infection with a fungus of the genus CANDIDA. It is usually a superficial infection of the moist areas of the body and is generally caused by CANDIDA ALBICANS. (Dorland, 27th ed)Electronic Mail: Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.Food Dispensers, Automatic: Mechanical food dispensing machines.Editorial Policies: The guidelines and policy statements set forth by the editor(s) or editorial board of a publication.Authorship: The profession of writing. Also the identity of the writer as the creator of a literary production.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Postal Service: The functions and activities carried out by the U.S. Postal Service, foreign postal services, and private postal services such as Federal Express.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Fluconazole: Triazole antifungal agent that is used to treat oropharyngeal CANDIDIASIS and cryptococcal MENINGITIS in AIDS.Candida: A genus of yeast-like mitosporic Saccharomycetales fungi characterized by producing yeast cells, mycelia, pseudomycelia, and blastophores. It is commonly part of the normal flora of the skin, mouth, intestinal tract, and vagina, but can cause a variety of infections, including CANDIDIASIS; ONYCHOMYCOSIS; vulvovaginal candidiasis (CANDIDIASIS, VULVOVAGINAL), and thrush (see CANDIDIASIS, ORAL). (From Dorland, 28th ed)Biological Products: Complex pharmaceutical substances, preparations, or matter derived from organisms usually obtained by biological methods or assay.Materia Medica: Materials or substances used in the composition of traditional medical remedies. The use of this term in MeSH was formerly restricted to historical articles or those concerned with traditional medicine, but it can also refer to homeopathic remedies. Nosodes are specific types of homeopathic remedies prepared from causal agents or disease products.Health Food: A non-medical term defined by the lay public as a food that has little or no preservatives, which has not undergone major processing, enrichment or refinement and which may be grown without pesticides. (from Segen, The Dictionary of Modern Medicine, 1992)Consumer Product SafetyAustralia: The smallest continent and an independent country, comprising six states and two territories. Its capital is Canberra.Hydrocortisone: The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.Insurance, Pharmaceutical Services: Insurance providing for payment of services rendered by the pharmacist. Services include the preparation and distribution of medical products.Commerce: The interchange of goods or commodities, especially on a large scale, between different countries or between populations within the same country. It includes trade (the buying, selling, or exchanging of commodities, whether wholesale or retail) and business (the purchase and sale of goods to make a profit). (From Random House Unabridged Dictionary, 2d ed, p411, p2005 & p283)Betamethasone Valerate: The 17-valerate derivative of BETAMETHASONE. It has substantial topical anti-inflammatory activity and relatively low systemic anti-inflammatory activity.Betamethasone: A glucocorticoid given orally, parenterally, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. Its lack of mineralocorticoid properties makes betamethasone particularly suitable for treating cerebral edema and congenital adrenal hyperplasia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p724)Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.Ointments: Semisolid preparations used topically for protective emollient effects or as a vehicle for local administration of medications. Ointment bases are various mixtures of fats, waxes, animal and plant oils and solid and liquid hydrocarbons.Polydipsia: Excessive thirst manifested by excessive fluid intake. It is characteristic of many diseases such as DIABETES MELLITUS; DIABETES INSIPIDUS; and NEPHROGENIC DIABETES INSIPIDUS. The condition may be psychogenic in origin.Polyuria: Urination of a large volume of urine with an increase in urinary frequency, commonly seen in diabetes (DIABETES MELLITUS; DIABETES INSIPIDUS).

Differences in the actions of some blockers of the calcium-activated potassium permeability in mammalian red cells. (1/278)

1. The actions of some inhibitors of the Ca2+-activated K+ permeability in mammalian red cells have been compared. 2. Block of the permeability was assessed from the reduction in the net loss of K+ that followed the application of the Ca2+ ionophore A23187 (2 microM) to rabbit red cells suspended at a haematocrit of 1% in a low potassium solution ([K]0 0.12-0.17 mM) at 37 degrees C. Net movement of K+ was measured using a K+-sensitive electrode placed in the suspension. 3. The concentrations (microM +/- s.d.) of the compounds tested causing 50% inhibition of K+ loss were: quinine, 37 +/- 3; cetiedil, 26 +/- 1; the cetiedil congeners UCL 1269, UCL 1274 and UCL 1495, approximately 150, 8.2 +/- 0.1, 0.92 +/- 0.03 respectively; clotrimazole, 1.2 +/- 0.1; nitrendipine, 3.6 +/- 0.5 and charybdotoxin, 0.015 +/- 0.002. 4. The characteristics of the block suggested that compounds could be placed in two groups. For one set (quinine, cetiedil, and the UCL congeners), the concentration-inhibition curves were steeper (Hill coefficient, nH, > or = 2.7) than for the other (clotrimazole, nitrendipine, charybdotoxin) for which nH approximately 1. 5. Compounds in the first set alone became less active on raising the concentration of K+ in the external solution to 5.4 mM. 6. The rate of K+ loss induced by A23187 slowed in the presence of high concentrations of cetiedil and its analogues, suggesting a use-dependent component to the inhibitory action. This was not seen with clotrimazole. 7. The blocking action of the cetiedil analogue UCL 1274 could not be overcome by an increase in external Ca2+ and its potency was unaltered when K+ loss was induced by the application of Pb2+ (10 microM) rather than by A23187. 8. These results, taken with the findings of others, suggest that agents that block the red cell Ca2+-activated K+ permeability can be placed in two groups with different mechanisms of action. The differences can be explained by supposing that clotrimazole and charybdotoxin act at the outer face of the channel whereas cetiedil and its congeners may block within it, either at or near the K+ binding site that determines the flow of K+.  (+info)

Effect of inhibitor depletion on inhibitory potency: tight binding inhibition of CYP3A by clotrimazole. (2/278)

The purpose of this work was to evaluate the effect of mutual unbound inhibitor and unbound enzyme depletion on the potency of three antifungal cytochrome P-450 (CYP)3A inhibitors with over 1000-fold range in enzyme affinity. Incubations were performed with human liver microsomal protein concentrations that varied from 25 to 1000 microg/ml. The effect of each inhibitor was evaluated using midazolam as a CYP3A probe. Clotrimazole was found to be a tight binding inhibitor of CYP3A with a Ki of 250 pM. Analysis of percent inhibition data by stepwise linear regression for the matrix of inhibitor and enzyme concentrations used showed that protein concentrations predicted the percent inhibition by clotrimazole (r2 = 0.60, p <.001). When clotrimazole concentrations were added to the model, the r2 improved to 0.81, p =.003. Clotrimazole concentrations alone were not a significant predictor of percent inhibition (r2 = 0. 21, p =.08). For ketoconazole, protein concentrations provided a weak prediction of the percent inhibition (r2 = 0.39, p =.006). Conversely, ketoconazole concentrations alone were a good predictor of percent inhibition (r2 = 0.55, p <.001). In contrast to results with clotrimazole and ketoconazole, percent inhibition by fluconazole was not dependent on protein concentrations (r2 = 0.06, p =.39). We conclude that microsomal inhibitory potency can be affected by incubation conditions that deplete the unbound concentration of inhibitor available to the enzyme. This may introduce serious error into a quantitative prediction of an in vivo drug-drug interaction based on an in vitro derived Ki value.  (+info)

In vitro susceptibilities of clinical yeast isolates to the new antifungal eberconazole compared with their susceptibilities to clotrimazole and ketoconazole. (3/278)

The antifungal activity of eberconazole, a new imidazole derivative, against 124 clinical isolates of Candida comprising eight different species and to 34 isolates of Cryptococcus neoformans was compared to those of clotrimazole and ketoconazole. MICs of eberconazole, determined by the National Committee for Clinical Laboratory Standards standardized microbroth method, were equal to or lower than those of other azoles, especially for Candida krusei and Candida glabrata, which are usually resistant to triazoles.  (+info)

The antifungal antibiotic clotrimazole potently inhibits L-type calcium current in guinea-pig ventricular myocytes. (4/278)

The antimycotic agent clotrimazole (CLT) is a promising potential therapeutic agent for a variety of diseases including cancer. Although it is known that CLT alters calcium homeostasis in many cell types, its cardiac effects are virtually unknown. We investigated the effects of CLT on L-type calcium current (ICa,L) and action potentials in guinea-pig ventricular myocytes. CLT (5, 25 and 50 microM) inhibited basal ICa,L by 16, 59 and 93%, respectively. The inhibitory effect of CLT was rapid and the peak effect was attained within 3 min. At a concentration of 25 microM, the inhibitory effect of CLT was partially reversible whereas the response to 50 microM CLT persisted following drug withdrawal. CLT abbreviated action potential duration at 50 and 90% of repolarization and suppressed the plateau significantly. These results indicate that CLT may have important cardiac effects at concentrations used to induce the antiproliferative action of the drug.  (+info)

Comparison of the toxicity of fluconazole and other azole antifungal drugs to murine and human granulocyte-macrophage progenitor cells in vitro. (5/278)

We studied the inhibitory effects on colony formation by granulocyte-macrophage colony forming units (cfu-gm) of eight azole antifungal agents in vitro. All agents, except fluconazole, inhibited colony formation dose-dependently with 50% inhibitory concentrations (IC50) in the range of 0.78-49 micromol/L in cultures of murine and human bone marrow. For human cells, the IC50 values were 0.553 mg/L for itraconazole, 1.24 mg/L for saperconazole, 2.58 mg/L for clotrimazole, 5.33 mg/L for miconazole, 6.17 mg/L for econazole, 6.27 mg/L for ketoconazole and 8.38 mg/L for oxiconazole. The IC50 of itraconazole for human cfu-gm in vitro was similar to the plasma level of this drug recommended for systemic antifungal therapy (>0.5 mg/L) thus indicating the potential clinical relevance of our data. The IC50 of ketoconazole for human cfu-gm in vitro may be exceeded by plasma levels produced in vivo by high (> or =400 mg) doses, whereas fluconazole failed to reduce colony formation by 50% even at 100 mg/L, a concentration not reached in vivo even after extremely high doses (2000 mg/day). To most of the drugs studied, murine progenitor cells seemed to be less sensitive than the human ones. There was, however, a close correlation between the murine and human log IC50 values of the drugs (r2 = 0.964, P< 0.001), suggesting that cultures of murine bone marrow may be suitable to predict the in-vitro toxicity of azole antifungals to human cfu-gm.  (+info)

In-vitro resistance to azoles associated with mitochondrial DNA deficiency in Candida glabrata. (6/278)

A commercially available disk diffusion procedure was used in a large-scale study to evaluate the susceptibility of a wide range of Candida isolates to polyenes and azoles. With almost all isolates of C. glabrata resistant colonies were present within the inhibition zones for the azole compounds fluconazole, ketoconazole and miconazole, and less frequently for isoconazole, econazole and clotrimazole. Ten randomly selected isolates were cloned by limiting dilution and the susceptibility of the resulting strains to polyenes and azoles was determined. All strains presented a similar susceptibility pattern with sensitivity to polyenes and the presence of resistant colonies for all azole compounds except tioconazole. For each strain and each antifungal agent, one of these resistant colonies was subcultured and studied for antifungal susceptibility. All these colonies showed similar properties regardless of which antifungal agent allowed their selection, with increased sensitivity to polyenes and cross-resistance to the azole compounds except tioconazole. Similar results were obtained on Shadomy's modified medium and on synthetic medium. Likewise, determination of MICs by the Etest method confirmed the resistance to fluconazole. Comparative growth studies revealed a respiratory deficiency in the mutants caused by mitochondrial DNA (mtDNA) deletions. In addition, 'petite' mutants were obtained from a wild-type strain by exposure to ethidium bromide, and these respiratory mutants were shown to be resistant to azoles. These results demonstrate the relationship between mtDNA deficiency and resistance to azoles, and provide an interesting model to study the mechanisms of action of these antifungal agents.  (+info)

Inhibition of T cell proliferation by selective block of Ca(2+)-activated K(+) channels. (7/278)

T lymphocytes express a plethora of distinct ion channels that participate in the control of calcium homeostasis and signal transduction. Potassium channels play a critical role in the modulation of T cell calcium signaling, and the significance of the voltage-dependent K channel, Kv1.3, is well established. The recent cloning of the Ca(2+)-activated, intermediate-conductance K(+) channel (IK channel) has enabled a detailed investigation of the role of this highly Ca(2+)-sensitive K(+) channel in the calcium signaling and subsequent regulation of T cell proliferation. The role IK channels play in T cell activation and proliferation has been investigated by using various blockers of IK channels. The Ca(2+)-activated K(+) current in human T cells is shown by the whole-cell voltage-clamp technique to be highly sensitive to clotrimazole, charybdotoxin, and nitrendipine, but not to ketoconazole. Clotrimazole, nitrendipine, and charybdotoxin block T cell activation induced by signals that elicit a rise in intracellular Ca(2+)-e.g., phytohemagglutinin, Con A, and antigens such as Candida albicans and tetanus toxin in a dose-dependent manner. The release of IFN-gamma from activated T cells is also inhibited after block of IK channels by clotrimazole. Clotrimazole and cyclosporin A act synergistically to inhibit T cell proliferation, which confirms that block of IK channels affects the process downstream from T cell receptor activation. We suggest that IK channels constitute another target for immune suppression.  (+info)

Formation of dense erythrocytes in SAD mice exposed to chronic hypoxia: evaluation of different therapeutic regimens and of a combination of oral clotrimazole and magnesium therapies. (8/278)

We have examined the effect of hydroxyurea (HU), clotrimazole (CLT), magnesium oxide (Mg), and combined CLT+Mg therapies on the erythrocyte characteristics and their response to chronic hypoxia in a transgenic sickle mouse (SAD) model. SAD mice were treated for 21 days with 1 of the following regimens (administered by gavage): control (n = 6), HU (200 mg/d; n = 6), CLT (80 mg/kg/d, n = 5), Mg (1,000 mg/kg/d, n = 5), and CLT+Mg (80 and 1,000 mg/kg/d, respectively, n = 6). Nine normal mice were also treated as controls (n = 3), HU (n = 3), and CLT+Mg (n = 3). Treatment with HU induced a significant increase in mean corpuscular volume and cell K content and a decrease in density in SAD mice. Treatment with the CLT and Mg, either alone or in combination, also increased cell K and reduced density in SAD mice. After 21 days of treatment, the animals were exposed to hypoxia (48 hours at 8% O(2)) maintaining the same treatment. In the SAD mice, hypoxia induced significant cell dehydration. These hypoxia-induced changes were blunted in either HU- or Mg-treated SAD mice and were completely abolished by either CLT or CLT+Mg treatment, suggesting a major role for the Gardos channel in hypoxia-induced dehydration in vivo.  (+info)

*Clotrimazole

Topical and oral clotrimazole can be used in both adults and children. Additionally, clotrimazole may be used to treat the ... Clotrimazole is usually used 5 times daily for 14 days for oral thrush, twice daily for 2 to 8 weeks for skin infections, and ... Clotrimazole, sold under the brand name Canesten among others, is an antifungal medication. It is used to treat vaginal yeast ... Clotrimazole may be compounded with a glucocorticoid, such as betamethasone, in a topical cream for the treatment of tinea ...

*List of drugs: H-He

Redirects to clotrimazole. Hexal Clotreme (Hexal Australia) [Au]. Redirects to clotrimazole. Hexal Comfarol Plus (Hexal ...

*Bifonazole

Berg, D; Regel, E; Harenberg, H. E.; Plempel, M (1984). "Bifonazole and clotrimazole. Their mode of action and the possible ...

*Flutrimazole

Clotrimazole The Merck Index, 12th Edition. 4247 Alomar, A; Videla, S; Delgadillo, J; Gich, I; Izquierdo, I; Forn, J (1995). " ... Its antifungal activity has been demonstrated in in vivo and in vitro studies to be comparable to that of clotrimazole and ...

*Anti-seborrheic

Clotrimazole is also used in treating seborrhoea. Other drugs like sulfur and resorcinol have also been found useful in ...

*Tinea

Treatment include : Grisofluvine, itraconazole and clotrimazole cream . Tinea capitis (also known as "Herpes tonsurans", " ...

*Dermatophyte

... clotrimazole, or tolnaftate. Antibiotics may be necessary to treat secondary bacterial infections that occur in addition to the ... Topical medications like clotrimazole, butenafine, miconazole, and terbinafine. Systemic medications (oral) like fluconazole, ...

*Pediatric gynaecology

They are treated with topical butoconazole, clotrimazole, or miconazole. Streptococcus infections are characterized by a dark ...

*Candidiasis

For infections of the mouth, treatment with topical clotrimazole or nystatin is usually effective. By mouth or intravenous ... A number of topical antifungal medications may be used for vaginal infections including clotrimazole. In those with widespread ... Candidiasis is treated with antifungal medications; these include clotrimazole, nystatin, fluconazole, voriconazole, ...

*Otomax

The active ingredients of are gentamicin, betamethasone valerate and clotrimazole. Otomax is used for treatment of acute ... and fungi susceptible to clotrimazole, in particular Malassezia pachydermatis. The normal treatment is twice daily for a ...

*TRPM5

Clotrimazole is an antifungal drug and reduces the currents through TRPM5. Nicotine inhibits the TRPM5 channel. Through the ...

*Isoconazole

The Merck Index, 12th Edition, 5176 Oyeka, C.A.; Gugnani H.C. (1992). "Isoconazole nitrate versus clotrimazole in foot and nail ... Cohen, L. (1984). "Single dose treatment of vaginal candidosis: comparison of clotrimazole and isoconazole". Retrieved 2008-05- ... isoconazole has a similar effectiveness to clotrimazole. Isoconazole nitrate may be used in combination with corticosteroid ...

*Dermatophytosis

Treatment is typically with antifungal creams such as clotrimazole or miconazole. If the scalp is involved, antifungals by ... Antifungal treatments include topical agents such as miconazole, terbinafine, clotrimazole, ketoconazole, or tolnaftate applied ...

*Whitfield's ointment

Individual studies, for instance "Treatment of superficial mycoses in the tropics: Whitfield's ointment versus clotrimazole" ... Whitfield's ointment versus clotrimazole". Int J Dermatol. 33 (10): 738-42. doi:10.1111/j.1365-4362.1994.tb01524.x. PMID ...

*Geotrichosis

Amphotericin B, clotrimazole and S-fluorocytosine have become more susceptible to G. candidum. Antimycotic resistance can ... Azole drugs including isoconazole and clotrimazole are used for geotrichosis treatment. Associated treatment for pulmonary ...

*Vaginal yeast infection

This may be either as a cream such as clotrimazole or with oral medications such as fluconazole. Probiotics have not been found ... Candidal vulvovaginitis in pregnancy should be treated with intravaginal clotrimazole or nystatin for at least 7 days. All are ... The following treatments are typically recommended: Intravaginal agents: butoconazole, clotrimazole, miconazole, nystatin, ...

*Pitted keratolysis

Hyperhidrosis Erythrasma Tinea pedis Fucidin ointment, other topical antibiotics and imidazoles such as clotrimazole. Botulinum ...

*Imidazole

A number of substituted imidazoles, including clotrimazole, are selective inhibitors of nitric oxide synthase, which makes them ... Imidazoles belong to the class of azole antifungals, which includes ketoconazole, miconazole, and clotrimazole. For comparison ... "Inhibition of tumor growth and prolonged survival of rats with intracranial gliomas following administration of clotrimazole". ...

*Burow's solution

In cases of otomycosis it is less effective than clotrimazole but remains an effective treatment. Most versions of Burow's ...

*Tinea incognito

These combinations include betamethasone dipropionate and clotrimazole (trade name Lotrisone) and triamcinolone acetonide and ... clotrimazole. In area of open skin, these combinations are acceptable in treating fungal infection of the skin. Unfortunately, ...

*Jerusalem Biblical Zoo

"Use of a sustained release preparation of clotrimazole to treat dermatophytosis in a siamang (Hylobates syndactylus)". Journal ...

*Intertrigo

Antifungal powders, most commonly clotrimazole 1%, may also be used in conjunction with a barrier ointment. Diaper rash ...

*Angular cheilitis

This is usually with topical antifungal medication, such as clotrimazole, amphotericin B, ketoconazole, or nystatin cream. Some ...

*Erythrasma

The topical 2% clotrimazole cream was more effective only when an associated fungal infection was present. Another study ... The general conclusion made was that topical 2% fusidic acid cream was found to be more effective than 2% clotrimazole cream in ... In a 2016 study performed by Prathyusha Prabhakar and H. Hema, they looked into comparing 2% clotrimazole cream and 2% Fusidic ... Prabhakar, Prathyusha (2016-09-19). "ERYTHRASMA - A CLINICAL AND A COMPARATIVE STUDY OF TOPICAL 2% CLOTRIMAZOLE CREAM VS ...

*Betamethasone

In Mexico it is also sold mixed with both clotrimazole and gentamicin to add an antibacterial agent to the mix. Betamethasone/ ... betamethasone is mixed with clotrimazole and sold as Lotrisone and Lotriderm. It is also available in combination with ...
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Product Name: Clotrimazole Vaginal Tablets. Common Name: Anti-infective tablets. Strength: 100 mg. Description:. Clotrimazole is commonly available as an over-the-counter substance in various dosage forms, such as a cream, vaginal tablet, or as a prescription troche or throat lozenge.. Clotrimazole works to kill individual Candida or fungal cells by altering the permeability of the fungal cell wall. It binds tophospholipids in the cell membrane and inhibits the biosynthesis of ergosterol and other sterols required for cell membraneproduction. This leads to the cells death via loss of intracellular element. Indications and Usage:. Clotrimazole is used for vulvovaginal candidiasis (yeast infection) or yeast infections of the skin. For vulvovaginal candidiasis (yeast infection), clotrimazole tablets and creams are inserted into the vagina. Troche or throat lozenge preparations are used fororopharyngeal candidiasis (oral thrush) or prophylaxis against oral thrush in neutropenic patients. It is used ...
Drugs and Supplements Clotrimazole topical preparations are used to treat fungus infections on the Drugs & Supplements; Clotrimazole (Topical Route). Drugs Related by Can i take tramadol with pristiq to Clotrimazole: Topical cream *Brand contains same active ingredient but may not represent FDA-approved generic equivalent.. Clotrimazole is used to treat skin infections such as athletes foot, jock itch, ringworm, and other fungal skin infections (candidiasis). This medication is also used. In various formulas, tioconazole, clotrimazole, and miconazole nitrate are products containing clotrimazole were available 60 Therapeutic Medications in. For products containing betamethasone, tuberculosis of the skin and PRODUCTS There are other products containing clotrimazole for otic use; refer to the.. Each gram of LOTRISONE cream contains 10 mg clotrimazole and 0.643 mg Stop using this medication and call your doctor at once if you have any of these. List of Clotrimazole brands plus detailed ...
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Is Clotrimazole helpful for Herpes? can Clotrimazole cause Herpes? "I was diagnosed with herpes yearsw ago and I haven t had an outbreak for quite some time. I went to my doctor today & she gave me another topical cream to use (clotrimazole). I ve used this before " I havent seen one of those in a while. I really. What cream can I use for herpes - Blisters/rash on right side head of penis. Tested Talk to your doctor: You would have to talk to your doctor for a cream or pill to take for the outbreak. Once you Can I use "clotrimazole and betamethasone disproportionate cream, use 1% % base" on the herpes around the anus?. When I was diagnosed with congenital herpes, I was too in elderly to really listen to my gyno as he threw how to can you use clotrimazole for herpes decision of and cough future outbreaks. My first outbreak was in. He conjugated mg of valtrex per day for can you use clotrimazole for herpes use and mg per day with an infection. He has also targeted me very worried and nervous if i ...
It is commonly available without a prescription in various dosage forms, such as a topical cream, ointment, or vaginal suppository. It is also available as an oral troche or throat lozenge as a prescription only. Topically, clotrimazole is used for vulvovaginal candidiasis (yeast infection) or yeast infections of the skin. For vulvovaginal candidiasis (yeast infection), clotrimazole tablets and creams are inserted into the vagina. Topical clotrimazole is usually not effective in treatment of fungal infections of the scalp or nails.[citation needed] When using over-the-counter drug clotrimazole products, use should be discontinued if condition does not improve after treatment for 2 weeks for jock itch or after 4 weeks for athletes foot or ringworm.[6] Throat lozenge preparations are used for oropharyngeal candidiasis (oral thrush) or prevention of oral thrush in people with neutropenia.[6] Clotrimazole is usually used 5 times daily for 14 days for oral thrush, twice daily for 2 to 8 weeks for ...
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Canesten Oral & Cream Duo [Gyne-Lotrimin] is a complete and convenient treatment for vaginal or penile thrush. The active substances in the capsule and cream are fluconazole and clotrimazole, respectively. Fluconazole and clotrimazole belong to a group of medicines called azoles and are antifungal agents which fight the cause of infections such as thrush.
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If you have an allergy to clotrimazole or any other part of clotrimazole ( oral). Thrush, also called candidiasis or white mouth, is a fungus infection. A three- dimensional representation of the compound. Mycelex® Troches, white discoid, uncoated tablets are supplied in bottles of. Quinlan2 1 Hunter College, Department of Computer Sciences, 695 Park Ave, NY, NY 10028, 2 Lehman College, CUNY, 250 Bedford Park Blvd. ; If you are allergic to any drugs like this one, any other drugs, foods, or other substances. What do I need to tell my doctor BEFORE I take Clotrimazole? Vaginal clotrimazole is used to treat vaginal yeast infections in adults and children 12 years of age and older. It is used to treat or prevent fungal infections in the mouth. Brand names include: Mycelex Troche ...
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If the infection does not clear up after you have finished one course of therapy, or if it appears to get worse, see your doctor. You may have another type of infection.. STORAGE. Avoid getting this medication in your eyes, nose, or mouth. Store clotrimazole vaginal at room temperature away from moisture and heat.. MORE INFO:. Active ingredient: Clotrimazole. Clotrimazole is an antifungal medication. It prevents fungus from growing.. Clotrimazole vaginal is used to treat vaginal candida (yeast) infections.. It also may be used for purposes other than those listed in this medication guide.. SAFETY INFORMATION. Do not use clotrimazole vaginal if you have ever had an allergic reaction to it ...
Clotrimazole, an N-substituted imidazole widely used as an antifungal agent, has been shown to both inhibit and induce hepatic cytochrome P-450 and related monooxygenase activities. In this study the profile of hepatic cytochrome P-450 isozyme(s) induced by clotrimazole treatment of male Sprague-Dawley rats was investigated. Clotrimazole administration (100 mg/kg, daily for 4 days, ig) resulted in 86% induction of spectrally detectable cytochrome P-450 in hepatic microsomes. In these microsomes 7-ethoxycoumarin O-deethylase (126%), aminopyrine N-demethylase (176%), benzphetamine N-demethylase (117%), p-nitrophenol hydroxylase (89%), and 7-ethoxyresorufin O-deethylase (62%) activities were significantly induced, whereas aryl hydrocarbon hydroxylase activity remained unchanged. Characterization of cytochrome P-450 isozyme(s) in hepatic microsomes prepared from clotrimazole-treated animals was based on the immunoreactivity of these microsomes with highly specific monoclonal antibodies (MAbs) raised ...
Clotrimazole (Lotrisone, Lotriderm, Lotrimin) is an antifungal medication belonging to the Azole class of medications. It is used to treat skin and nail fungal and gram positive infections including yeast infections.
Clotrimazole Cream is a medicine that is used for the treatment of Fungal Skin Infection Of Vagina, Fungal Infections Of Penis, Fungal Infections Of Groin
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In Fig. 2A, CAR1 and CAR2 activity in COS-1 cells was tested with increasing concentrations of clotrimazole. In the DMSO control group, the activity of CAR2 was 73.4% of CAR1 activity. At 0.5 μM clotrimazole, CAR1 activity was markedly reduced, and then only modestly decreased in inhibition across the rest of the concentrations tested. In contrast, CAR2 was only weakly inhibited at lower concentrations; its activity equaled CAR1 at 0.5 and 1.0 μM. At higher doses, CAR2 activity decreased much more rapidly than CAR1. At 5 μM CAR2, activity again drops below CAR1 and continues to decrease up to 25 μM, at which point it is strongly repressed, exhibiting only 15.8% of the activity of CAR1 at that concentration. To further investigate the effect of clotrimazole as well as another CAR1 inverse agonist, androstanol, similar experiments were conducted in HepG2 cells (Fig. 2, B and C). A comparable trend was seen under these conditions, such that the response of CAR1 was almost maximal by 1 μM ...
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TY - JOUR. T1 - Mechanisms of retinoid resistance in leukemic cells. T2 - Possible role of cytochrome P450 and P-glycoprotein. AU - Kizaki, Masahiro. AU - Ueno, Hironori. AU - Yamazoe, Yasushi. AU - Shimada, Miki. AU - Takayama, Nobuyuki. AU - Muto, Akihiro. AU - Matsushita, Hiromichi. AU - Nakajima, Hideaki. AU - Morikawa, Minoru. AU - Koeffler, H. Phillip. AU - Ikeda, Yasuo. PY - 1996/1/15. Y1 - 1996/1/15. N2 - Retinoic acid (RA) regulates the differentiation and proliferation of a wide variety of different cell types and all-trans RA induces complete remission in a high proportion of patients with acute promyelocytic leukemia (APL). However, clinical resistance to retinoids may develop and poses a serious problem for differentiation-inducing therapy. We studied the effects of RA in combination with a cytochrome P450 inhibitor (clotrimazole) and a P- glycoprotein antagonist (verapamil) on cell growth and differentiation of RA- resistant HL-60 cells and fresh RA-resistant leukemic cells from ...
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OBJECTIVES. Otitis externa, both acute and chronic and their possible complications are very common in canine clinic. In some cases of otitis externa, the appearance of resistant germs as Pseudomonas spp or E. coli or Proteus mirabilis that acts as perpetuation factors of the pathology or yeast (Malassezia pachydermatis) constitute a difficult problem for the practitioner to treat it with effectiveness and speed.. The reason of the present study is to evaluate the effectiveness of a new eardrops solution for otitis externa in dogs: association of a fluoroquinolone (marbofloxacin), an anti-fungal (Clotrimazole) and anti-inflammatory (Dexamethasone as acetate).. The study was aimed mainly to dogs, of any race and age, affected of otitis externa with presence of secretion or extensive suppuration. All cases were identified by using cytology and bacterial culture.. MATERIALS. Seven veterinary clinics participated in the study. 51 dogs were included of both sexes, different races, ages, with acute ...
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  • Do not let clotrimazole get into your eyes and do not swallow the medication. (medlineplus.gov)
  • Pregnant women are more at risk of yeast infections, and clotrimazole appears to be a safe, effective medication to treat them. (wisegeek.com)
  • One reason for the safety of clotrimazole in pregnancy is the low absorption rate of topical forms of the drug, which means that very little of the medication reaches the fetus. (wisegeek.com)
  • It may be possible to buy a medication over the counter that would be appropriate for handling the yeast infection, or a medical professional might prefer to prescribe a specific formulation of clotrimazole known to be safe in pregnancy. (wisegeek.com)
  • Studies on clotrimazole in breastfeeding women are more limited, but the medication also appears to be safe in this setting. (wisegeek.com)
  • Patients should wash their hands after applying topical clotrimazole to avoid transferring it to other areas of the body, which will limit the chance an infant has direct contact with the medication. (wisegeek.com)
  • If you are using clotrimazole to treat jock itch, your symptoms should improve over 2 weeks of treatment. (medlineplus.gov)
  • I couldn't bear the itching anymore and the clotrimazole treated my symptoms within days. (wisegeek.com)
  • Is It Safe to Use Clotrimazole in Pregnancy? (wisegeek.com)
  • Studies on the use of clotrimazole in pregnancy indicate that it is generally safe, with no increased risk of miscarriage or birth defects. (wisegeek.com)
  • To err on the side of safety, medical professionals may only recommend that a patient take clotrimazole in pregnancy if it is absolutely necessary. (wisegeek.com)
  • Side effects can occur when a patient takes clotrimazole in pregnancy. (wisegeek.com)
  • The reaction to clotrimazole in pregnancy might be the result of an allergy , or increased skin sensitivity associated with the pregnancy. (wisegeek.com)
  • I had to use clotrimazole vaginal suppositories several times during my pregnancy. (wisegeek.com)
  • Clotrimazole is absolutely fine during pregnancy. (wisegeek.com)
  • They can you use clotrimazole in early pregnancy are found in minutes and aCEI leukotriene receptor antagonist therapy. (musicaenlamochila.net)
  • They may cause thirst, manifested either can you use clotrimazole in early pregnancy to hydrocortisone. (musicaenlamochila.net)
  • Additionally, clotrimazole may be used to treat the sickling of cells (related to sickle cell anemia ). (wikipedia.org)
  • Vaginal clotrimazole is used to treat vaginal yeast infections in adults and children 12 years of age and older. (medlineplus.gov)
  • Clotrimazole topical preparations are used to treat fungus infections on the skin. (mayoclinic.org)
  • When clotrimazole is used to treat certain types of fungus infections of the skin, an occlusive dressing (airtight covering, such as kitchen plastic wrap) should not be applied over the medicine. (mayoclinic.org)
  • Spectrum™ Clotrimazole, Powder, USP is an azole antifungal used to treat skin infections. (fishersci.com)
  • You should begin to feel better during the first three days of treatment with clotrimazole. (medlineplus.gov)
  • you should know that condoms and diaphragms may be weakened if they are used during your treatment with vaginal clotrimazole. (medlineplus.gov)
  • Crompton, G.K. and Milne, L.J.R. Treatment of bronchopulmonary aspergillosis with clotrimazole. (springer.com)
  • Cartwright R.Y. (1976) Oral Clotrimazole In The Treatment Of Füngal Infection. (springer.com)
  • Topical and oral clotrimazole can be used in both adults and children. (wikipedia.org)
  • Although there is no specific information comparing use of topical clotrimazole in the elderly with use in other age groups, this medicine is not expected to cause different side effects or problems in older people than it does in younger adults. (mayoclinic.org)
  • Contact allergy to clotrimazole. (bmj.com)
  • Roller J A . Contact allergy to clotrimazole. (bmj.com)
  • If you become pregnant while using clotrimazole, call your doctor. (medlineplus.gov)
  • But I'm glad that there are treatments like clotrimazole that are effective and safe to use. (wisegeek.com)
  • If this is the first time you have had vaginal itching and discomfort, talk to a doctor before using clotrimazole. (medlineplus.gov)
  • There were no interactions found in our database between beclomethasone and clotrimazole - however, this does not necessarily mean no interactions exist. (drugs.com)