Clostridium sordellii: A species of gram-positive bacteria in the family Clostridiaceae, found in INTESTINES and SOIL.Clostridium: A genus of motile or nonmotile gram-positive bacteria of the family Clostridiaceae. Many species have been identified with some being pathogenic. They occur in water, soil, and in the intestinal tract of humans and lower animals.Clostridium Infections: Infections with bacteria of the genus CLOSTRIDIUM.Clostridium difficile: A common inhabitant of the colon flora in human infants and sometimes in adults. It produces a toxin that causes pseudomembranous enterocolitis (ENTEROCOLITIS, PSEUDOMEMBRANOUS) in patients receiving antibiotic therapy.Bacterial Toxins: Toxic substances formed in or elaborated by bacteria; they are usually proteins with high molecular weight and antigenicity; some are used as antibiotics and some to skin test for the presence of or susceptibility to certain diseases.Abortifacient Agents: Chemical substances that interrupt pregnancy after implantation.Endometritis: Inflammation of the ENDOMETRIUM, usually caused by intrauterine infections. Endometritis is the most common cause of postpartum fever.Antitoxins: Antisera from immunized animals that is purified and used as a passive immunizing agent against specific BACTERIAL TOXINS.Spores: The reproductive elements of lower organisms, such as BACTERIA; FUNGI; and cryptogamic plants.Neuromuscular Junction Diseases: Conditions characterized by impaired transmission of impulses at the NEUROMUSCULAR JUNCTION. This may result from disorders that affect receptor function, pre- or postsynaptic membrane function, or ACETYLCHOLINESTERASE activity. The majority of diseases in this category are associated with autoimmune, toxic, or inherited conditions.Uridine Diphosphate Glucose: A key intermediate in carbohydrate metabolism. Serves as a precursor of glycogen, can be metabolized into UDPgalactose and UDPglucuronic acid which can then be incorporated into polysaccharides as galactose and glucuronic acid. Also serves as a precursor of sucrose lipopolysaccharides, and glycosphingolipids.Classification: The systematic arrangement of entities in any field into categories classes based on common characteristics such as properties, morphology, subject matter, etc.Cytotoxins: Substances that are toxic to cells; they may be involved in immunity or may be contained in venoms. These are distinguished from CYTOSTATIC AGENTS in degree of effect. Some of them are used as CYTOTOXIC ANTIBIOTICS. The mechanism of action of many of these are as ALKYLATING AGENTS or MITOSIS MODULATORS.Clostridium botulinum: A species of anaerobic, gram-positive, rod-shaped bacteria in the family Clostridiaceae that produces proteins with characteristic neurotoxicity. It is the etiologic agent of BOTULISM in humans, wild fowl, HORSES; and CATTLE. Seven subtypes (sometimes called antigenic types, or strains) exist, each producing a different botulinum toxin (BOTULINUM TOXINS). The organism and its spores are widely distributed in nature.Enterotoxins: Substances that are toxic to the intestinal tract causing vomiting, diarrhea, etc.; most common enterotoxins are produced by bacteria.Glucosyltransferases: Enzymes that catalyze the transfer of glucose from a nucleoside diphosphate glucose to an acceptor molecule which is frequently another carbohydrate. EC 2.4.1.-.rac GTP-Binding Proteins: A sub-family of RHO GTP-BINDING PROTEINS that is involved in regulating the organization of cytoskeletal filaments. This enzyme was formerly listed as EC 126.96.36.199.Shock, Septic: Sepsis associated with HYPOTENSION or hypoperfusion despite adequate fluid resuscitation. Perfusion abnormalities may include, but are not limited to LACTIC ACIDOSIS; OLIGURIA; or acute alteration in mental status.Bacterial Proteins: Proteins found in any species of bacterium.Quality Control: A system for verifying and maintaining a desired level of quality in a product or process by careful planning, use of proper equipment, continued inspection, and corrective action as required. (Random House Unabridged Dictionary, 2d ed)Bacteria, AnaerobicGas Gangrene: A severe condition resulting from bacteria invading healthy muscle from adjacent traumatized muscle or soft tissue. The infection originates in a wound contaminated with bacteria of the genus CLOSTRIDIUM. C. perfringens accounts for the majority of cases (over eighty percent), while C. noyvi, C. septicum, and C. histolyticum cause most of the other cases.Nostrums: Medicines whose effectiveness is unproven and whose ingredients are often secret.Quackery: The fraudulent misrepresentation of the diagnosis and treatment of disease.Microbial Sensitivity Tests: Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).Drug Packaging: Containers, packaging, and packaging materials for drugs and BIOLOGICAL PRODUCTS. These include those in ampule, capsule, tablet, solution or other forms. Packaging includes immediate-containers, secondary-containers, and cartons. In the United States, such packaging is controlled under the Federal Food, Drug, and Cosmetic Act which also stipulates requirements for tamper-resistance and child-resistance. Similar laws govern use elsewhere. (From Code of Federal Regulations, 21 CFR 1 Section 210, 1993) DRUG LABELING is also available.Anti-Bacterial Agents: Substances that reduce the growth or reproduction of BACTERIA.Quality of Life: A generic concept reflecting concern with the modification and enhancement of life attributes, e.g., physical, political, moral and social environment; the overall condition of a human life.Drug Contamination: The presence of organisms, or any foreign material that makes a drug preparation impure.Superantigens: Microbial antigens that have in common an extremely potent activating effect on T-cells that bear a specific variable region. Superantigens cross-link the variable region with class II MHC proteins regardless of the peptide binding in the T-cell receptor's pocket. The result is a transient expansion and subsequent death and anergy of the T-cells with the appropriate variable regions.Menstrual Hygiene Products: Personal care items used during MENSTRUATION.Staphylococcus aureus: Potentially pathogenic bacteria found in nasal membranes, skin, hair follicles, and perineum of warm-blooded animals. They may cause a wide range of infections and intoxications.Tampons, Surgical: Plugs or cylinders made of cotton, sponge, or other absorbent material. They are used in surgery to absorb fluids such as blood or drainage.Peptide Library: A collection of cloned peptides, or chemically synthesized peptides, frequently consisting of all possible combinations of amino acids making up an n-amino acid peptide.Protein Engineering: Procedures by which protein structure and function are changed or created in vitro by altering existing or synthesizing new structural genes that direct the synthesis of proteins with sought-after properties. Such procedures may include the design of MOLECULAR MODELS of proteins using COMPUTER GRAPHICS or other molecular modeling techniques; site-specific mutagenesis (MUTAGENESIS, SITE-SPECIFIC) of existing genes; and DIRECTED MOLECULAR EVOLUTION techniques to create new genes.Antibodies: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Jupiter: The fifth planet in order from the sun. It is one of the five outer planets of the solar system. Its sixteen natural satellites include Callisto, Europa, Ganymede, and Io.Antibody Affinity: A measure of the binding strength between antibody and a simple hapten or antigen determinant. It depends on the closeness of stereochemical fit between antibody combining sites and antigen determinants, on the size of the area of contact between them, and on the distribution of charged and hydrophobic groups. It includes the concept of "avidity," which refers to the strength of the antigen-antibody bond after formation of reversible complexes.Genetic Engineering: Directed modification of the gene complement of a living organism by such techniques as altering the DNA, substituting genetic material by means of a virus, transplanting whole nuclei, transplanting cell hybrids, etc.Taurochenodeoxycholic Acid: A bile salt formed in the liver by conjugation of chenodeoxycholate with taurine, usually as the sodium salt. It acts as detergent to solubilize fats in the small intestine and is itself absorbed. It is used as a cholagogue and choleretic.Cholagogues and Choleretics: Gastrointestinal agents that stimulate the flow of bile into the duodenum (cholagogues) or stimulate the production of bile by the liver (choleretic).Osmotic Pressure: The pressure required to prevent the passage of solvent through a semipermeable membrane that separates a pure solvent from a solution of the solvent and solute or that separates different concentrations of a solution. It is proportional to the osmolality of the solution.Leucine Zippers: DNA-binding motifs formed from two alpha-helixes which intertwine for about eight turns into a coiled coil and then bifurcate to form Y shaped structures. Leucines occurring in heptad repeats end up on the same sides of the helixes and are adjacent to each other in the stem of the Y (the "zipper" region). The DNA-binding residues are located in the bifurcated region of the Y.Endoplasmic Reticulum Stress: Various physiological or molecular disturbances that impair ENDOPLASMIC RETICULUM function. It triggers many responses, including UNFOLDED PROTEIN RESPONSE, which may lead to APOPTOSIS; and AUTOPHAGY.Endoplasmic Reticulum: A system of cisternae in the CYTOPLASM of many cells. In places the endoplasmic reticulum is continuous with the plasma membrane (CELL MEMBRANE) or outer membrane of the nuclear envelope. If the outer surfaces of the endoplasmic reticulum membranes are coated with ribosomes, the endoplasmic reticulum is said to be rough-surfaced (ENDOPLASMIC RETICULUM, ROUGH); otherwise it is said to be smooth-surfaced (ENDOPLASMIC RETICULUM, SMOOTH). (King & Stansfield, A Dictionary of Genetics, 4th ed)Ursodeoxycholic Acid: An epimer of chenodeoxycholic acid. It is a mammalian bile acid found first in the bear and is apparently either a precursor or a product of chenodeoxycholate. Its administration changes the composition of bile and may dissolve gallstones. It is used as a cholagogue and choleretic.Abortion, Induced: Intentional removal of a fetus from the uterus by any of a number of techniques. (POPLINE, 1978)Gynecology: A medical-surgical specialty concerned with the physiology and disorders primarily of the female genital tract, as well as female endocrinology and reproductive physiology.GeorgiaAbortion, Spontaneous: Expulsion of the product of FERTILIZATION before completing the term of GESTATION and without deliberate interference.Abortion, Missed: The retention in the UTERUS of a dead FETUS two months or more after its DEATH.Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
A phosphatidylserine-binding site in the cytosolic fragment of Clostridium sordellii lethal toxin facilitates glucosylation of membrane-bound Rac and is required for cytotoxicity. (1/28)Large clostridial toxins glucosylate some small G proteins on a threonine residue, thereby preventing their interactions with effector molecules and regulators. We show that the glucosyltransferase domain of lethal toxin from Clostridium sordellii (LT(cyt); amino acids 1-546), which is released into the cytosol during cell infection, binds preferentially to liposomes containing phosphatidylserine as compared with other anionic lipids. The binding of LT(cyt) to phosphatidylserine increases by two orders of magnitude the rate of glucosylation of liposome-bound geranyl-geranylated Rac-GDP. Limited proteolysis and deletion studies show that the binding site for phosphatidylserine lies within the first 18 N-terminal residues of LT(cyt). Deletion of these residues abolishes the effect of phosphatidylserine on the activity of LT(cyt) on liposome-bound geranyl-geranylated Rac-GDP and prevents the morphological effects induced by LT(cyt) microinjection into various cells, but it does not affect the intrinsic activity of LT(cyt) on non-geranyl-geranylated Rac-GDP in solution. We conclude that the avidity of LT(cyt) for phosphatidylserine facilitates its targeting to the cytosolic leaflet of cell membranes and, notably, the plasma membrane, where this anionic lipid is abundant and where several targets of lethal toxin reside. (+info)
Clostridium sordellii toxic shock syndrome after medical abortion with mifepristone and intravaginal misoprostol--United States and Canada, 2001-2005. (2/28)On July 19, 2005, the Food and Drug Administration (FDA) issued a public health advisory regarding the deaths of four women in the United States after medical abortions with Mifeprex (mifepristone, formerly RU-486; Danco Laboratories, New York, New York) and intravaginal misoprostol. Two of these deaths occurred in 2003, one in 2004, and one in 2005. Two of these U.S. cases had clinical illness consistent with toxic shock and had evidence of endometrial infection with Clostridium sordellii, a gram-positive, toxin-forming anaerobic bacteria. In addition, a fatal case of C. sordellii toxic shock syndrome after medical abortion with mifepristone and misoprostol was reported in 2001, in Canada. All three cases of C. sordellii infection were notable for lack of fever, and all had refractory hypotension, multiple effusions, hemoconcentration, and a profound leukocytosis. C. sordellii previously has been described as a cause of pregnancy-associated toxic shock syndrome. (+info)
Fatal toxic shock syndrome associated with Clostridium sordellii after medical abortion. (3/28)Endometritis and toxic shock syndrome associated with Clostridium sordellii have previously been reported after childbirth and, in one case, after medical abortion. We describe four deaths due to endometritis and toxic shock syndrome associated with C. sordellii that occurred within one week after medically induced abortions. Clinical findings included tachycardia, hypotension, edema, hemoconcentration, profound leukocytosis, and absence of fever. These cases indicate the need for physician awareness of this syndrome and for further study of its association with medical abortion. (+info)
Sudden death associated with Clostridium sordellii in captive lions (Panthera leo). (4/28)In the spring of 2003, a series of sudden deaths in a group of adult lions (Panthera leo) with a previous history of depression, inanition, and lethargy, was investigated. Five animals died within 24 to 36 hours after onset of signs of disease. Serologic screening for viral disease detection was negative, evidence of parasites was not detected, and results of a complete blood count and serum biochemical analysis were within reference intervals in all lions. The most relevant lesions observed were multiple areas of necrosis and hemorrhage in the intestinal outer muscular layer, and cellulitis with an intense bloody edema in the mesenteric and the pericardial fat tissue. On the basis of the fulminant course of the disease, the gross and histologic findings, and the isolation and identification of Clostridium sordellii, a diagnosis of infectious myositis and cellulitis associated with acute clostridiosis was made. To the authors' knowledge, this is the first report of sudden death associated with C. sordellii in felines. (+info)
Clostridium sordellii infection: epidemiology, clinical findings, and current perspectives on diagnosis and treatment. (5/28)Clostridium sordellii infections pose difficult clinical challenges and are usually fatal. Most commonly, these infections occur after trauma, childbirth, and routine gynecological procedures, but they have recently been associated with medically induced abortions and injection drug use. We report 2 fatal cases, one of which was associated with minor trauma, and the other of which was associated with normal childbirth, and we summarize the clinical features of 43 additional cases of reported C. sordellii infection. Of these 45 cases, 8 (18%) were associated with normal childbirth, 5 (11%) were associated with medically induced abortion, and 2 (0.4%) were associated with spontaneous abortion. The case-fatality rate was 100% in these groups. Ten (22%) of the C. sordellii infections occurred in injection drug users, and 50% of these patients died. Other cases of C. sordellii infection (in 19 patients [43%]) occurred after trauma or surgery, mostly in healthy persons, and 53% these patients died. Overall, the mortality rate was 69% (31 of 45 patients). Eighty-five percent of all patients with fatal cases died within 2-6 days of initial infection, and nearly 80% of fatal cases developed leukemoid reactions. Rapid diagnostic tests and improved treatments are needed to reduced the morbidity and mortality associated with this devastating infection. (+info)
Infection of internal umbilical remnant in foals by Clostridium sordellii. (6/28)Omphalitis and the resulting septicemia contribute to perinatal mortality in several animal species. In foals, the most important causes of omphalitis are Escherichia coli and Streptococcus zooepidemicus. However to date, no information has been published about the role of Clostridium sordellii in these infections. In this paper, we describe 8 cases of perinatal mortality in foals associated with internal umbilical remnant infection by C. sordellii. The foals studied were between 12 and 21 days old at the time of death, and various breeds were represented in the group. Five of the foals were male and 3 were female. The diagnosis was established on the basis of the detection of C. sordellii by 3 methods (culture, fluorescent antibody test, and immunohistochemistry) and on gross and histopathologic findings. All foals had acute peritonitis, and the internal umbilical remnant was thickened by edema, hemorrhage, and fibrosis. A moderate amount of serosanguinous fluid with fibrin strands was present in the pericardial sac and pleural cavity. Histopathologically, the urachus and umbilical arterial walls were thickened by edema and exhibited hemorrhage, fibrin, and leukocytic infiltration. Gram-positive bacterial rods were observed in subepithelial areas of the urachus, the adventicia of umbilical arteries, and interstitium of the internal umbilical remnant. On the basis of these findings, we suggest that C. sordellii should be considered in the differential diagnosis for infections of the internal umbilical remnant in foals. (+info)
The leukemoid reaction in Clostridium sordellii infection: neuraminidase induction of promyelocytic cell proliferation. (7/28)Life-threatening Clostridium sordellii infections have recently been reported in women undergoing therapeutic abortion, during natural childbirth, and in injection drug users. Shock, diffuse capillary leak, and a leukemoid reaction (LR) are cardinal features of these infections. The magnitude of the LR is highly correlated with mortality. We have isolated a 42-kDa extractable protein from C. sordellii culture supernatant that stimulates proliferation of promyelocytic HL-60 cells in vitro. Using mass spectrometry, we have identified this protein as the C. sordellii neuraminidase, NanS. Recombinant NanS (rNanS) dose dependently stimulated HL-60 cell proliferation. Increased proliferation was observed when HL-60 cells were cocultured with both rNanS and granulocyte-macrophage colony stimulating factor. In addition, NanS also modified vascular cell adhesion molecule 1, which orchestrates the release of mature and immature granulocytes from bone marrow stromal cells. Thus, neuraminidase likely plays an important role in the characteristic LR in C. sordellii infection. (+info)
The large clostridial toxins from Clostridium sordellii and C. difficile repress glucocorticoid receptor activity. (8/28)We have previously shown that Bacillus anthracis lethal toxin represses glucocorticoid receptor (GR) transactivation. We now report that repression of GR activity also occurs with the large clostridial toxins produced by Clostridium sordellii and C. difficile. This was demonstrated using a transient transfection assay system for GR transactivation. We also report that C. sordellii lethal toxin inhibited GR function in an ex vivo assay, where toxin reduced the dexamethasone suppression of the proinflammatory cytokine tumor necrosis factor alpha (TNF-alpha). Furthermore, the glucocorticoid antagonist RU-486 in combination with C. sordellii lethal toxin additively prevented glucocorticoid suppression of TNF-alpha. These findings corroborate the fact that GR is a target for the toxin and suggest a physiological role for toxin-associated GR repression in inflammation. Finally, we show that this repression is associated with toxins that inactivate p38 mitogen-activated protein kinase (MAPK). (+info)
Mifepriston, wolna encyklopedia
a b Cohen AL, Bhatnagar J. Toxic shock associated with Clostridium sordellii and Clostridium perfringens after medical and ... Fatal Clostridium sordellii Infections after Medical Abortions. „N Engl J Med", s. 1382-1383, 2010-09-30 (ang.). ... Clostridium sordellii to Gram-dodatnia laseczka, kolonizująca drogi rodne u 0,5-10% kobiet. Bywa ona sporadycznie przyczyną ... Pathophysiology of mifepristone-induced septic shock due to Clostridium sordellii. „Ann Pharmacother". 39 (9), s. 1483-1488, ...
Just I, Selzer J, Hofmann F, Green GA, Aktories K (April 1996). "Inactivation of Ras by Clostridium sordellii lethal toxin- ... Some authors include Clostridium haemolyticum as Clostridium novyi type D. C novyi is closely related to Clostridium botulinum ... toxins of Clostridium difficile show homology with the alpha-toxin of C novyi as does the lethal toxin of clostridium sordellii ... Clostridium novyi (oedematiens) a Gram-positive, endospore- forming, obligate anaerobic bacteria of the class clostridia. It is ...
... sordellii three days later. M. J. Aldape, A. E. Bryant, D. L. Stevens; Clostridium sordellii Infection: Epidemiology, Clinical ... McGregor.pdf Pathema-Clostridium Resource Type strain of Clostridium sordellii at BacDive - the Bacterial Diversity ... Clostridium sordellii is a rare anaerobic, gram-positive, spore-forming rod with peritrichous flagella that is capable of ... C. sordellii bacteremia and sepsis occur rarely. Most cases of sepsis from C. sordellii occur in patients with underlying ...
Clostridium difficile toxin B
These bacterial toxins have been shown to be associated with Clostridium sordellii hemorrhagic toxin (TcsH), lethal toxin (TcsL ... Clostridium difficile toxin B is a toxin produced by the bacteria Clostridium difficile. C. difficile produces two major kinds ... Clostridium difficile TcdE Holin Holin Reinert DJ, Jank T, Aktories K, Schulz GE (September 2005). "Structural basis for the ... With regard to Clostridium difficile-associated diarrhea (CDAD), the effects of cytopathicity are more critical than actual ...
List of MeSH codes (B03)
Clostridium perfringens MeSH B03.300.390.400.200.700 --- Clostridium sordellii MeSH B03.300.390.400.200.710 --- Clostridium ... Clostridium perfringens MeSH B03.510.415.400.200.700 --- Clostridium sordellii MeSH B03.510.415.400.200.710 --- Clostridium ... Clostridium butyricum MeSH B03.300.390.400.200.200 --- Clostridium cellulolyticum MeSH B03.300.390.400.200.205 --- Clostridium ... clostridium difficile MeSH B03.300.390.400.200.412 --- Clostridium histolyticum MeSH B03.300.390.400.200.493 --- Clostridium ...
Toxins | Free Full-Text | Role of p38alpha/beta MAP Kinase in Cell Susceptibility to Clostridium sordellii Lethal Toxin and...
Lethal Toxin from Clostridium sordellii (TcsL), which is casually involved in the toxic shock syndrome and in gas gangrene, enters its target cells by receptor-mediated endocytosis. Inside the cell, TcsL mono-O-glucosylates and thereby inactivates Rac/Cdc42 and Ras subtype GTPases, resulting in actin reorganization and an activation of p38 MAP kinase. While a role of p38 MAP kinase in TcsL-induced cell death is well established, data on a role of p38 MAP kinase in TcsL-induced actin reorganization are not available. In this study, TcsL-induced Rac/Cdc42 glucosylation and actin reorganization are differentially analyzed in p38alpha−/− MSCV empty vector MEFs and the corresponding cell line with reconstituted p38alpha expression (p38alpha−/− MSCV p38alpha MEFs). Genetic deletion of p38alpha results in reduced susceptibility of cells to TcsL-induced Rac/Cdc42 glucosylation and actin reorganization. Furthermore, SB203580, a pyridinyl imidazole inhibitor of p38alpha/beta MAP kinase, also protects
Clostridium sordellii ATCC ® 9714™ Designation: 211 TypeStrain=True Application: Quality control strain Control strain for anaerobe identification Quality control strain for API, BBL, IDS, and MicroScan [Reg TM] products
Clostridium sordellii ATCC ® 9714™ Designation: 211 TypeStrain=True Application: Quality control strain Control strain for anaerobe identification Quality control strain for API, BBL, IDS, and MicroScan [Reg TM] products
Definition of clostridial toxin in the Financial Dictionary - by Free online English dictionary and encyclopedia. What is clostridial toxin? Meaning of clostridial toxin as a finance term. What does clostridial toxin mean in finance?
The Minnesota Department of Health (MDOH) has received reports of three previously healthy persons who died unexpectedly following uncomplicated knee surgery; two had total knee replacements and one had a cartilage graft implantation. The surgeries were performed at two local hospitals. Two patients died on November 11, 2001, and one died on November 16, approximately 36--82 hours following surgery. CDC is assisting MDOH in the investigation of these events. All three patients became ill 1--4 days following surgery. Symptoms included severe abdominal pain and a sudden decline in blood pressure followed by a fulminant course with death within 24 hours of symptom onset. The clinical course was consistent with septic or cardiogenic shock. After 5 days of incubation, a blood culture taken from one of the patients yielded Clostridium sordellii. The source of infection in the one patient and the cause of death in all patients remain unknown. In response to these deaths, MDOH is recommending that all ...
Clostridium difficile is an important nosocomial pathogen, resulting in antibiotic-associated disease ranging from mild diarrhoea to the life-threatening pseudomembranous colitis. Upon antibiotic exposure, it is believed that the normal bowel microflora of patients is disrupted, allowing C. difficile to proliferate. Significantly, C. difficile is among only a few bacteria able to ferment tyrosine to p-cresol, a phenolic compound that is toxic to other microbes via its ability to interfere with metabolism. Therefore, the ability of different C. difficile strains to produce and tolerate p-cresol may play an important role in the development and severity of C. difficile-associated disease. In this study, it was demonstrated that two C. difficile hypervirulent 027 strains (Stoke Mandeville and BI-16) are more tolerant to p-cresol than other C. difficile strains including 630, CF4 and CD196. Surprising, it was shown that Clostridium sordellii also has a high tolerance to p-cresol, suggesting an overlap in
Agents for treating pain, methods for producing the agents and methods for treating pain by administration to a patient of a therapeutically effective amount of the agent. The agent can include a clostridial neurotoxin, or a component or fragment or derivative thereof, attached to a targeting moiety, wherein the targeting moiety is selected from a group consisting of transmission compounds which can be released from neurons upon the transmission of pain signals by the neurons, and compounds substantially similar to the transmission compounds.
Methods for treating fibromyalgia may include administering a therapeutically effective amount of a Clostridial toxin to a peripheral location on the body of a patient. This peripheral location is other than the site on the body where the pain emanates.
Extreme leukocytosis and leukemoid reaction associated with the lung sarcomatoid carcinoma: an unusual case report Danyang Wang, Haiyan Zhang, Fengkuan Yu, Baijun Fang Department of Hematopathy, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, People’s Republic of China Purpose: To report a rare case of extreme leukocytosis and leukemoid reaction associated with lung sarcomatoid carcinoma (LSC) and increase people’s awareness of the disease. Patients and methods: A 58-year-old male patient was diagnosed with LSC; however, after the end of the second course of chemotherapy, his white blood cells increased gradually without fever or use of medications such as granulocyte colony-stimulating factor and steroids. A bone marrow biopsy then confirmed it to be a leukemoid reaction. Results: The patient died of multiple organ failure 2 months after being diagnosed with leukocytosis. Conclusion: LSC associated with leukemoid reaction is very rare and the prognosis is
A successful pregnancy requires that the maternal immune system adapts to tolerate the semi-allogeneic fetal-placental unit. This adaptation mainly occurs locally, i.e. at the fetal-maternal interface, where fetal-derived tissues come into close contact with maternal cells in the uterine endometrium (called decidua during pregnancy). Macrophages and regulatory T (Treg) cells are maternal immune cells that are enriched in the decidua and they likely play a central role in promoting fetal tolerance. However, the precise function of decidual macrophages and the factors regulating both macrophages and Treg cells in humans are unknown. The aim of this thesis was to characterize the phenotype and function of decidual macrophages from first trimester human pregnancy and to identify factors responsible for inducing tolerogenic properties in both decidual macrophages and Treg cells. CD14+ decidual macrophages showed characteristics of immune suppressive or homeostatic macrophages (expression of CD163, ...
Leukemoid reaction with pulmonary carcinoma has been a rare observation. Three cases are presented in detail with possible mechanisms contributing to the production of a leukemoid blood picture.
Conference Comment: The contributor provides a good summary of C. piliforme, an atypical member of the genus Clostridium. Other members of the clostridia are large, Gram positive spore forming bacteria with straight or slightly curved morphology, in contrast the filamentous, Gram negative spore forming C. piliforme.(2) Further differentiating C. piliforme from other clostridia is the fact that it does not possess characteristics that allow its inclusion into one of the three general categories of the other pathogenic members of the genus. These categories of clostridia are neurotoxic (C. tetani, C. botulinum types A-G), histotoxic (C. chauvoei, C. septicum, C. novyi types A and B, C. perfringens type A, C. sordellii, C. hemolyticum), and enteropathogenic/enterotoxemia-producing (C. perfringens types A-E, C. difficile, C. colinum, C. spiroforme).(2 ...
For use in healthy cattle and calves three months of age or older as an aid in preventing blackleg caused by Clostridium chauvoei, malignant edema caused by Cl. septicum, black disease caused by Cl. novyi, gas-gangrene caused by Cl. sordellii, enterotoxemia and enteritis caused by Cl. perfringens Types B, C and D, and disease caused by Histophilus somni (Haemophilus somnus). Although Cl. perfringens Type B is not a significant problem in North America, immunity is provided by the beta toxoid of Type C and the epsilon toxoid of Type D. Ultrabac 7/Somubac consists of killed, standardized cultures of Cl. chauvoei, Cl. septicum, Cl. novyi, Cl. sordellii, Cl. perfringens Types C and D, and H. somni, with an adjuvant. Available in a 10 dose or 50 dose.. ...
A leukemoid reaction (LR) is a hematological disorder, defined by a leukocyte count greater than 50,000 cells/mcL with reactive causes outside the bone ...
IJMS | Free Full-Text | Decidual Macrophages Are Significantly Increased in Spontaneous Miscarriages and Over-Express FasL: A...
Decidual macrophages (DM) are the second most abundant population in the fetal-maternal interface. Their role has been so far identified as being local immuno-modulators favoring the maternal tolerance to the fetus. Herein we investigated tissue samples from 11 cases of spontaneous miscarriages and from 9 cases of elective terminations of pregnancy. Using immunohistochemistry and dual immunofluorescence we have demonstrated that in spontaneous miscarriages the DM are significantly increased. Additionally, we noted a significant up-regulation of macrophage FasL expression. Our results further support a dual role for DM during pregnancy and miscarriages. We hypothesize that the baseline DM population in normal pregnancy is in line with an M2 phenotype supporting the ongoing gestation. In contrast, during spontaneous miscarriages, the increased FasL-expressing population could be a part of an M1 phenotype participating in Fas/FasL-related apoptosis. Our results highlight a new aspect of macrophage biology
One Shot Ultra 8 Cattle Vaccine aids in the prevention of blackleg, malignant edema, bacilary hemoglobinuria, black disease, enterotoxemia and enteritis, and bovine pneumonia.
Flow cytometric characterisation of cell populations in human pregnancy decidua and isolation of decidual macrophages. -...
Methods have been developed for isolating human tissue macrophages from first trimester or term pregnancy decidua. After a two stage enzymic digestion, viable cells were separated from cellular debris by velocity sedimentation at unit gravity or by Percoll centrifugation. Cell populations were analysed by flow cytometry after labelling with monoclonal antibodies. In term decidua, 47% of the cells were of bone marrow origin, comprising 18% macrophages, 3% large granular lymphocytes and 8% T cells. The remaining cells, the proportion of which varied between individuals, were CD16-positive granulocytes. Macrophages were isolated flow cytometrically from both first trimester and term decidual cell dispersions after labelling with an antibody to MHC class II. Yields of up to 4 X 10(6) macrophages, greater than 95% pure, were routinely obtained.
For use in healthy cattle and sheep as an aid in preventing disease caused by Clostridium chauvoei (Blackleg), septicum (Malignant edema), haemolyticum (Bacilliary Hemoglobinuria (Red Water)), novyl (Black disease), sordellii and perfringens Types C&D (Enterotoxemia).
Lauren Wesser who had her leg amputed due to a a rare tampon infection now educates girls about Toxic Shock Syndrome. | This model lost her leg to Toxic Shock Syndrome. What is it?
Severe leukocytosis with neutrophilia (leukemoid reaction) in alcoholic steatohepatitis. - PubMed - NCBI
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DMOZ - Health: Conditions and Diseases: Infectious Diseases: Bacterial: Staphylococcal: Toxic Shock Syndrome
Toxic Shock Syndrome is most often caused by staphylococcal bacterial toxins, but streptococcal bacteria can cause a similar illness.
Wearing the same tampon for an extended amount of time could lead to a rare, but sometimes deadly disease called toxic shock syndrome (TSS). The National Women
Mum Lou Harvey-Smith revealed her sons terrifying ordeal after contracting Toxic Shock Syndrome after burning himself - only to be misdiagnosed...
Researchers from the University of Maryland School of Medicine and their colleagues have identified the structure of the most lethal toxin produced by certain strains of Clostridium difficile bacteria, a potentially deadly infection associated with the use of antibiotics. The
Clostridium sordellii (Hall and Scott) Prevot ATCC ® 9714™
Clostridium sordellii ATCC ® 9714™ Designation: 211 TypeStrain=True Application: Quality control strain Control strain for ... Nucleotide (GenBank) : M59105 Clostridium sordellii 16S ribosomal RNA. Nucleotide (GenBank) : L12058 Clostridium sordellii 7- ... Clostridium sordellii (Hall and Scott) Prevot (ATCC® 9714™) Strain Designations: 211 [NCIB 10717] / Type Strain: yes / ... Clostridium sordellii (Hall and Scott) Prevot (ATCC® 9714-MINI-PACK™) Add to ...https://www.atcc.org/Products/Quality_Control_Strains/By_Organization__Company/9714.aspx?slp=1
Clostridium sordellii (Hall and Scott) Prevot ATCC ® 9714™
Clostridium sordellii ATCC ® 9714™ Designation: 211 TypeStrain=True Application: Quality control strain Control strain for ... Nucleotide (GenBank) : M59105 Clostridium sordellii 16S ribosomal RNA. Nucleotide (GenBank) : L12058 Clostridium sordellii 7- ... Clostridium sordellii (Hall and Scott) Prevot (ATCC® 9714™) Strain Designations: 211 [NCIB 10717] / Type Strain: yes / ... Clostridium sordellii (Hall and Scott) Prevot (ATCC® 9714-MINI-PACK™) Add to ...https://www.atcc.org/Global/Products/4/C/9/4/9714.aspx
Toxins | Free Full-Text | Role of p38alpha/beta MAP Kinase in Cell Susceptibility to Clostridium sordellii Lethal Toxin and...
Lethal Toxin from Clostridium sordellii (TcsL), which is casually involved in the toxic shock syndrome and in gas gangrene, ... Role of p38alpha/beta MAP Kinase in Cell Susceptibility to Clostridium sordellii Lethal Toxin and Clostridium difficile Toxin B ... "Role of p38alpha/beta MAP Kinase in Cell Susceptibility to Clostridium sordellii Lethal Toxin and Clostridium difficile Toxin B ... Role of p38alpha/beta MAP Kinase in Cell Susceptibility to Clostridium sordellii Lethal Toxin and Clostridium difficile Toxin B ...http://www.mdpi.com/2072-6651/9/1/2
Frontiers | Osmotic Stress Induced Cell Death in Wheat Is Alleviated by Tauroursodeoxycholic Acid and Involves Endoplasmic...
Schulz, F., Just, I., and Genth, H. (2009). Prevention of Clostridium sordellii lethal toxin-induced apoptotic cell death by ...https://www.frontiersin.org/articles/10.3389/fpls.2017.00667/full
Clostridium sordellii | HAI | CDC
General Information about C. sordellii. Clostridium sordellii [klaw-strĭ-dee-um sore-dell-ee-i] (also called C. sordellii) is a ... Toxic shock associated with clostridium sordellii and clostridium perfringens after medical and spontaneous abortion.external ... It is not known how C. sordellii is spread between persons or from the environment to persons. Other similar Clostridium ... For more information see the Clostridium sordellii Toxic Shock Syndrome After Medical Abortion with Mifepristone and ...http://www.cdc.gov/HAI/organisms/cSordellii.html
Clostridium sordellii - definition of Clostridium sordellii by The Free Dictionary
Clostridium sordellii synonyms, Clostridium sordellii pronunciation, Clostridium sordellii translation, English dictionary ... definition of Clostridium sordellii. n. pl. clos·trid·i·a Any of various rod-shaped, spore-forming, chiefly anaerobic bacteria ... of the genus Clostridium, such as certain nitrogen-fixing species... ... Clostridium chauvoei, Clostridium septicum, Clostridium perfringens, Clostridium novyi, Clostridium Sordellii, por exemplo, ...http://www.thefreedictionary.com/Clostridium+sordellii
Clostridium sordellii - Wikipedia
... sordellii three days later. M. J. Aldape, A. E. Bryant, D. L. Stevens; Clostridium sordellii Infection: Epidemiology, Clinical ... McGregor.pdf Pathema-Clostridium Resource Type strain of Clostridium sordellii at BacDive - the Bacterial Diversity ... Clostridium sordellii is a rare anaerobic, gram-positive, spore-forming rod with peritrichous flagella that is capable of ... C. sordellii bacteremia and sepsis occur rarely. Most cases of sepsis from C. sordellii occur in patients with underlying ...https://en.wikipedia.org/wiki/Clostridium_sordellii
Clostridium sordellii - microbewiki
In 1927 the organism was renamed Bacillus sordellii and two years later it became classified as Clostridium sordellii, as it is ... In women, the C. sordellii infection can develop into Clostridium sordellii Toxic Shock Sydrome (CSTS), which is associated ... The mechanism of transmission for Clostridium sordellii between person to person or person to environment is not known . ... A study published by The American Journal of Pathology investigated the effects of Clostridium sordellii in mice. The lethal ...https://microbewiki.kenyon.edu/index.php?title=Clostridium_sordellii&
Toxins | Free Full-Text | The Tip of the Four N-Terminal α-Helices of Clostridium sordellii Lethal Toxin Contains the...
Clostridium sordellii lethal toxin (TcsL) is a powerful virulence factor responsible for severe toxic shock in man and animals ... Keywords: Clostridium sordellii; Clostridium difficile; large clostridial glucosylating toxin; C. sordellii lethal toxin; ... This article belongs to the Collection Clostridium difficile/Clostridium sordellii and Clostridium perfringens Toxins) ... Ras Clostridium sordellii; Clostridium difficile; large clostridial glucosylating toxin; C. sordellii lethal toxin; ...https://www.mdpi.com/2072-6651/8/4/90
Clostridium sordellii Pathogenicity Locus Plasmid pCS1-1 Encodes a Novel Clostridial Conjugation Locus | mBio
Tetracycline-resistance genes of Clostridium perfringens, Clostridium septicum and Clostridium sordellii isolated from cattle ... Toxic shock associated with Clostridium sordellii and Clostridium perfringens after medical and spontaneous abortion. Obstet ... Clostridium sordellii in enteritis in an adult sheep. Vet Rec 112:19. doi:10.1136/vr.112.1.19. ... Clostridium sordellii lethal toxin kills mice by inducing a major increase in lung vascular permeability. Am J Pathol 170:1003- ...https://mbio.asm.org/content/9/1/e01761-17
Clostridium species (Clostridium perfringens, C. butyricum, C. clostridioforme, C. innocuum, C. ramosum, C. septicum, C....
Clostridium sordellii and C. septicum posses susceptibility similar to C. perfringens, although there are occasional strains ... Clostridium innocuum and Clostridium ramosen compared with these of clinical isolates of Clostridium perfringens. J Clin ... by Clostridium sporogenes, Clostridium novyi and Clostridium botulinum (14). ... Clostridium sordellii bacteremia: case report and review. Clin Infect Dis. 1992;15:950-4. [PubMed] ...http://www.antimicrobe.org/b90.asp
Clostridium sordellii Lethal-Toxin Autoprocessing and Membrane Localization Activities Drive GTPase Glucosylation Profiles in...
Clostridium sordellii Lethal-Toxin Autoprocessing and Membrane Localization Activities Drive GTPase Glucosylation Profiles in ... Clostridium sordellii Lethal-Toxin Autoprocessing and Membrane Localization Activities Drive GTPase Glucosylation Profiles in ... Clostridium sordellii Lethal-Toxin Autoprocessing and Membrane Localization Activities Drive GTPase Glucosylation Profiles in ... Clostridium sordellii Lethal-Toxin Autoprocessing and Membrane Localization Activities Drive GTPase Glucosylation Profiles in ...https://msphere.asm.org/content/1/1/e00012-15/figures-only
Glucosylation of Ras by Clostridium sordellii lethal toxin: consequences for effector loop conformations observed by NMR...
The lethal toxin (LT) from Clostridium sordellii, which belongs to the family of large clostridial cytotoxins, acts as a ... The lethal toxin (LT) from Clostridium sordellii, which belongs to the family of large clostridial cytotoxins, acts as a ... Glucosylation of Ras by Clostridium sordellii lethal toxin: consequences for effector loop conformations observed by NMR ... Glucosylation of Ras by Clostridium sordellii lethal toxin: consequences for effector loop conformations observed by NMR ...https://epub.uni-regensburg.de/16602/
Glucosylation of Ras by Clostridium sordellii Lethal Toxin: Consequences for Effector Loop Conformations Observed by...
Glucosylation of Ras by Clostridium sordellii Lethal Toxin: Consequences for Effector Loop Conformations Observed by NMR ...https://www.infona.pl/resource/bwmeta1.element.acs-doi-10_1021_bi034529v
... * General information. *. the following information is not yet verified. Taxonomy. Family: ... Most cases of sepsis from C. sordellii occur in patients with underlying conditions.. Severe toxic shock syndrome among ... previously healthy persons has been described in a small number of C. sordellii cases, most often associated with gynecologic ...http://microbe-canvas.com/Bacteria.php?p=1313
Author: 'Stahl, Christina' / Subject: Clostridium sordellii and skeletal muscle - PubAg Search Results
Clostridium sordellii Remove constraint Subject: Clostridium sordellii Subject skeletal muscle Remove constraint Subject: ... 1. Lethal toxin of Clostridium sordellii is associated with fatal equine atypical myopathy ... horses; Clostridium sordellii; bacterial infections; horse diseases; bacterial toxins; septic shock; mortality; myocardial ... The lethal toxin of Clostridium sordellii (TcsL) evokes severe, mostly fatal disease patterns like toxic shock syndrome in ...https://pubag.nal.usda.gov/?f%5Bsubject_term%5D%5B%5D=Clostridium+sordellii&f%5Bsubject_term%5D%5B%5D=skeletal+muscle&q=%22Stahl%2C+Christina%22&search_field=author&sort=title
Author: 'Stahl, Christina' / Subject: Clostridium sordellii and septic shock - PubAg Search Results
Clostridium sordellii Remove constraint Subject: Clostridium sordellii Subject septic shock Remove constraint Subject: septic ... 1. Lethal toxin of Clostridium sordellii is associated with fatal equine atypical myopathy ... horses; Clostridium sordellii; bacterial infections; horse diseases; bacterial toxins; septic shock; mortality; myocardial ... The lethal toxin of Clostridium sordellii (TcsL) evokes severe, mostly fatal disease patterns like toxic shock syndrome in ...https://pubag.nal.usda.gov/?f%5Bsubject_term%5D%5B%5D=Clostridium+sordellii&f%5Bsubject_term%5D%5B%5D=septic+shock&q=%22Stahl%2C+Christina%22&search_field=author&sort=title
Clostridium sordellii infection | Genetic and Rare Diseases Information Center (GARD) - an NCATS Program
... information resources and questions answered by our Genetic and Rare Diseases Information Specialists for Clostridium sordellii ... ClinicalTrials.gov lists trials that are related to Clostridium sordellii infection. Click on the link to go to ClinicalTrials. ... PubMed is a searchable database of medical literature and lists journal articles that discuss Clostridium sordellii infection. ... Clostridium sordellii infection Title Other Names:. Clostridium sordellii toxic shock syndrome; C. sordellii infection ...https://phgkb.cdc.gov/PHGKB/phgHome.action?action=forward&dbsource=cluster&id=28368
Bacterial Preceptrol Cultures Page 1
Clostridium sordellii (Hall and Scott) Prevot (ATCC® 9714™) ATCC® Number: 9714™ Strain Designations: 211 [NCIB 10717] ... Clostridium perfringens (Veillon and Zuber) Hauduroy et al. (ATCC® 13124™) ATCC® Number: 13124™ Strain Designations: NCTC 8237 ...https://atcc.org/en/Products/Cells_and_Microorganisms/Bacteria/Preceptrol_Cultures.aspx?dsNav=Ns:Organism_Accepted_Name%7C101%7C1%7C,N:4294963051
Preceptrol Cultures Page 1
Clostridium sordellii (Hall and Scott) Prevot (ATCC® 9714™) ATCC® Number: 9714™ Strain Designations: 211 [NCIB 10717] ... Clostridium perfringens (Veillon and Zuber) Hauduroy et al. (ATCC® 13124™) ATCC® Number: 13124™ Strain Designations: NCTC 8237 ... Clostridium septicum (Mace) Ford (ATCC® 12464™) ATCC® Number: 12464™ Strain Designations: Pasteur III (NCTC 547) ...https://atcc.org/en/Products/Collections/Preceptrol_Cultures.aspx?dsNav=Ns:Organism_Accepted_Name%7C101%7C1%7C,N:4294958095
Bile Acid 7α-Dehydroxylating Gut Bacteria Secrete Antibiotics that Inhibit Clostridium difficile: Role of Secondary Bile Acids....
1-acetyl-β-carboline; Clostridium difficile; Clostridium scindens; Clostridium sordellii; cyclic dipeptides; dysbiosis; gut ... A) PYF medium control; B) C. difficile grown in 50% C. sordellii spent culture medium; C) C. diffiicle incubated in 100% C. ... The purification protocols for antibacterial compounds secreted by C. sordellii and C. scindens are described in . The LC-ESI/ ... Clostridium scindens biotransforms primary bile acids into secondary bile acids, and is correlated with inhibition of ...https://www.ncbi.nlm.nih.gov/pubmed/30482679
Bacteriology/Mycology | Veterinary Diagnostic Laboratory - University of Minnesota
Fluorescent Antibody, Clostridia spp. (chauvoei, novyi, sordellii, septicum). Specimen Requirements: 1) affected tissue 2) 5 ...https://www.vdl.umn.edu/services-fees/bacteriologymycology
Septic Abortion: Prevention and Management | GLOWM
FATAL INFECTION WITH CLOSTRIDIUM SORDELLII. Nine deaths have occurred in the US, and one in Canada, from Clostridium sordellii ... infection with Clostridium perfringens is largely associated with illegal abortions.8 Recently Clostridium sordellii has been ... Meites E, Zane S, Gould C: Fatal Clostridium sordellii infections after medical abortions. N Engl J Med. 2010 Sep 30;363(14): ... Fatal toxic shock syndrome associated with Clostridium sordellii after medical abortion. N Eng J Med 2005;353:2352 ...http://www.glowm.com/section_view/item/437/recordset/71685/value/437
Ballard JD[au] - PubMed - NCBI
Clostridium sordellii toxic shock syndrome.. Aronoff DM, Ballard JD.. Lancet Infect Dis. 2009 Dec;9(12):725-6. doi: 10.1016/ ... Intrinsic Toxin-Derived Peptides Destabilize and Inactivate Clostridium difficile TcdB.. Larabee JL, Bland SJ, Hunt JJ, Ballard ... TcdB from hypervirulent Clostridium difficile exhibits increased efficiency of autoprocessing.. Lanis JM, Hightower LD, Shen A ... Clostridium difficile ClpP Homologues are Capable of Uncoupled Activity and Exhibit Different Levels of Susceptibility to ...https://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Ballard+JD%5Bau%5D&dispmax=50
Rapid, simultaneous detection of Clostridium sordellii and Clostridium perfringens in archived tissues by a novel PCR-based...
... sordellii infections (,90%). Deaths from Clostridium sordellii and Clostridium perfringens toxic shock (CTS) are sudden, and ... Clostridium sordellii and Clostridium perfringens are infrequent human pathogens; however, the case-fatality rates for the ... Rapid, simultaneous detection of Clostridium sordellii and Clostridium perfringens in archived tissues by a novel PCR-based ... Rapid, Simultaneous Detection of Clostridium sordellii and Clostridium perfringens in Archived Tissues by a Novel PCR-Based ...https://phgkb.cdc.gov/PHGKB/phgHome.action?action=forward&dbsource=cdcpub&id=1362
- There are several clinical features which are unique to C. sordellii: marked leukocytosis (leukaemoid reaction), refractory hypotension, severe tachycardia, haemoconcentration, persistent apyrexia and profound capillary leak syndrome (see entry for Clostridium novyi alpha-toxin for details of mechanism. (wikipedia.org)
- A major virulence factor in Clostridium sordellii -mediated infection is the toxin TcsL, which is encoded within a region of the genome called the pathogenicity locus (PaLoc). (asm.org)
- The cst locus is present on all pCS1 subtypes, and homologous loci were identified on toxin-encoding plasmids from Clostridium perfringens and Clostridium botulinum and also carried within genomes of Clostridium difficile isolates, indicating that it is a widespread clostridial conjugation locus. (asm.org)
- While the pathogenesis of C. sordellii infections is not well understood, it is known that the toxin TcsL is an important virulence factor. (asm.org)
- Lethal Toxin from Clostridium sordellii (TcsL), which is casually involved in the toxic shock syndrome and in gas gangrene, enters its target cells by receptor-mediated endocytosis. (mdpi.com)
- Clostridium sordellii lethal toxin (TcsL) is a powerful virulence factor responsible for severe toxic shock in man and animals. (mdpi.com)
- The lethal toxin (LT) from Clostridium sordellii, which belongs to the family of large clostridial cytotoxins, acts as a monoglucosyltransferase for the Rho subfamily GTPase Rac and also modifies Ras. (uni-regensburg.de)
- The lethal toxin of Clostridium sordellii (TcsL) evokes severe, mostly fatal disease patterns like toxic shock syndrome in humans and animals. (usda.gov)
- Cell-penetrating peptides derived from Clostridium difficile TcdB2 and a related large clostridial toxin. (nih.gov)
- Intrinsic Toxin-Derived Peptides Destabilize and Inactivate Clostridium difficile TcdB. (nih.gov)
- Coordination between T helper cells, iNKT cells, and their follicular helper subsets in the humoral immune response against Clostridium difficile toxin B. (nih.gov)
- Memory B Cells Encode Neutralizing Antibody Specific for Toxin B from the Clostridium difficile Strains VPI 10463 and NAP1/BI/027 but with Superior Neutralization of VPI 10463 Toxin B. (nih.gov)
- Specific inhibition of geranylgeranyltransferase-I and Rac/Cdc42 by GGTI-286 and Clostridium sordellii lethal toxin, respectively, enhanced TM expression, whereas inactivation of Rho by Clostridium botulinum C3 exoenzyme was ineffective. (ahajournals.org)
- The toxins normally produced by the various types are shown in table 1 The alpha-toxin of Clostridium botulinum types C and D, is similar to the C novyi beta-toxin. (wikipedia.org)
- The A and B toxins of Clostridium difficile show homology with the alpha-toxin of C novyi as does the lethal toxin of clostridium sordellii. (wikipedia.org)
- Severe toxic shock syndrome among previously healthy persons has been described in a small number of C. sordellii cases, most often associated with gynecologic infections in women and infection of the umbilical stump in newborns. (cdc.gov)
- Women are at highest risk of infection from C. sordellii following the end of pregnancy, whether that pregnancy ended in a live birth, induced abortion (medical or surgical), or spontaneous abortion (miscarriage). (cdc.gov)
- The rate of vaginal colonization (when bacteria are present, but not causing an infection) with Clostridium species in the period after abortion has been reported to be as high as 29%, whereas these bacteria have been isolated in the vaginal secretions of 5%-10% of non-pregnant women. (cdc.gov)
- Symptoms of a C. sordellii infection include nausea, vomiting, diarrhea, and sometimes abdominal pain without fever. (cdc.gov)
- Numerous case studies suggest that the incubation of C. sordellii after infection is 1 to 5 days . (kenyon.edu)
- A healthy 4-year-old boy sustained a closed fracture of the arm and died of Clostridium sordellii infection 4 days later. (thefreedictionary.com)
- Since 2000, five women North America who had medically induced abortions died from toxic shock caused by a Clostridium sordellii infection. (thefreedictionary.com)
- Pregnancy-associated infections - Toxic Shock Syndrome Also associated with a pediatric case where patient presented with a broken arm and was pronounced dead due to infection of C. sordellii three days later. (wikipedia.org)
- ClinicalTrials.gov lists trials that are related to Clostridium sordellii infection. (cdc.gov)
- PubMed is a searchable database of medical literature and lists journal articles that discuss Clostridium sordellii infection. (cdc.gov)
- Clostridium sordellii (or C. sordellii) normally exists in the vagina and does not cause infection. (vidanthealth.com)
- Wound infection by C novyi and many other clostridium species cause gas gangrene Spontaneous infection is mostly associated with predisposing factors of hematologic or colorectal malignancies and with diabetes mellitus, although Gram-negative organisms, including Escherichia coli, may lead to a gas gangrene-like syndrome in diabetic patients. (wikipedia.org)
- Some microbiologists hypothesize that the bacteria can travel from person to person and from contaminated surfaces to person in a similar manner to other Clostridium species, although there has yet to be a study confirming this to be true for C. sordellii . (kenyon.edu)
- Any of various rod-shaped, spore-forming, chiefly anaerobic bacteria of the genus Clostridium, such as certain nitrogen-fixing species found in soil and those causing botulism and tetanus. (thefreedictionary.com)
- The source of the bacteria has not been determined but it has been documented that about 0.5% to 10% of healthy women are lengthened vaginal carriage of C. sordellii. (wikipedia.org)
- Clostridium novyi (oedematiens) a Gram-positive, endospore- forming, obligate anaerobic bacteria of the class clostridia. (wikipedia.org)
- Illicit drug users are especially susceptible to C. sordellii infections and certain drugs have shown more apt to transmit the bacterium . (kenyon.edu)
- Along with IDU, C. sordelli infections have been associated with medically induced abortions, minor traumas and surgeries, spontaneous abortions and normal childbirth-the tools used in these operations are not found to carry C. sordellii on their surfaces . (kenyon.edu)
- The populations most susceptible to Clostridium sordellii infections are women nearing the end of pregnancy, whether that concludes in live birth, medical abortion, or miscarriage . (kenyon.edu)
- IMPORTANCE C. sordellii is a bacterial pathogen that causes severe infections in humans and animals, with high mortality rates. (asm.org)
- Clostridium sordellii infections. (vidanthealth.com)
- Intravenous drug use can also cause C. sordellii infections. (vidanthealth.com)
- Clostridium sordellii [klaw-strĭ-dee-um sore-dell-ee-i] (also called C. sordellii ) is a rare bacterium that causes pneumonia, endocarditis, arthritis, peritonitis, and myonecrosis. (cdc.gov)
- The pathogen that killed several abortion patients was Clostridium sordellii , a common bacterium that can prove deadly when it gets into the bloodstream. (thefreedictionary.com)
- So far, all documented post-partum females who contracted C. sordellii septicaemia have died, and all but one woman who contracted the bacterium post-abortion have died. (wikipedia.org)
- Other similar Clostridium species are spread from person to person and sometimes contaminated surfaces are involved in this transmission. (cdc.gov)
- There are no known zoonotic Clostridium species, meaning they cannot transmit directly from animal to human . (kenyon.edu)
- In general, Clostridium species are transmitted through contaminated wound sites and discontinuities in the gastrointestinal tract . (kenyon.edu)
- In Clostridium species the average incubation is 6 hours to 3 days . (kenyon.edu)
- Formalin-fixed, paraffin-embedded (FFPE) tissues usually are the only specimens available for sudden fatal cases, and immunohistochemistry (IHC) for Clostridia is generally performed but it cannot identify species. (cdc.gov)
- For more information see the Clostridium sordellii Toxic Shock Syndrome After Medical Abortion with Mifepristone and Intravaginal Misoprostol - United States and Canada, 2001-2005 . (cdc.gov)
- Undiagnosed cases of fatal clostridium-associated toxic shock in californian women of childbearing age. (cdc.gov)
- The mechanism of transmission for Clostridium sordellii between person to person or person to environment is not known . (kenyon.edu)
- A study published by The American Journal of Pathology investigated the effects of Clostridium sordellii in mice. (kenyon.edu)