A species of gram-positive bacteria in the family Clostridiaceae, found in INTESTINES and SOIL.
A genus of motile or nonmotile gram-positive bacteria of the family Clostridiaceae. Many species have been identified with some being pathogenic. They occur in water, soil, and in the intestinal tract of humans and lower animals.
Infections with bacteria of the genus CLOSTRIDIUM.
A common inhabitant of the colon flora in human infants and sometimes in adults. It produces a toxin that causes pseudomembranous enterocolitis (ENTEROCOLITIS, PSEUDOMEMBRANOUS) in patients receiving antibiotic therapy.
Toxic substances formed in or elaborated by bacteria; they are usually proteins with high molecular weight and antigenicity; some are used as antibiotics and some to skin test for the presence of or susceptibility to certain diseases.
Chemical substances that interrupt pregnancy after implantation.
Inflammation of the ENDOMETRIUM, usually caused by intrauterine infections. Endometritis is the most common cause of postpartum fever.
Antisera from immunized animals that is purified and used as a passive immunizing agent against specific BACTERIAL TOXINS.
The reproductive elements of lower organisms, such as BACTERIA; FUNGI; and cryptogamic plants.
Conditions characterized by impaired transmission of impulses at the NEUROMUSCULAR JUNCTION. This may result from disorders that affect receptor function, pre- or postsynaptic membrane function, or ACETYLCHOLINESTERASE activity. The majority of diseases in this category are associated with autoimmune, toxic, or inherited conditions.
A key intermediate in carbohydrate metabolism. Serves as a precursor of glycogen, can be metabolized into UDPgalactose and UDPglucuronic acid which can then be incorporated into polysaccharides as galactose and glucuronic acid. Also serves as a precursor of sucrose lipopolysaccharides, and glycosphingolipids.
The systematic arrangement of entities in any field into categories classes based on common characteristics such as properties, morphology, subject matter, etc.
Substances that are toxic to cells; they may be involved in immunity or may be contained in venoms. These are distinguished from CYTOSTATIC AGENTS in degree of effect. Some of them are used as CYTOTOXIC ANTIBIOTICS. The mechanism of action of many of these are as ALKYLATING AGENTS or MITOSIS MODULATORS.
A species of anaerobic, gram-positive, rod-shaped bacteria in the family Clostridiaceae that produces proteins with characteristic neurotoxicity. It is the etiologic agent of BOTULISM in humans, wild fowl, HORSES; and CATTLE. Seven subtypes (sometimes called antigenic types, or strains) exist, each producing a different botulinum toxin (BOTULINUM TOXINS). The organism and its spores are widely distributed in nature.
Substances that are toxic to the intestinal tract causing vomiting, diarrhea, etc.; most common enterotoxins are produced by bacteria.
Enzymes that catalyze the transfer of glucose from a nucleoside diphosphate glucose to an acceptor molecule which is frequently another carbohydrate. EC 2.4.1.-.
A sub-family of RHO GTP-BINDING PROTEINS that is involved in regulating the organization of cytoskeletal filaments. This enzyme was formerly listed as EC 3.6.1.47.
Sepsis associated with HYPOTENSION or hypoperfusion despite adequate fluid resuscitation. Perfusion abnormalities may include, but are not limited to LACTIC ACIDOSIS; OLIGURIA; or acute alteration in mental status.
Proteins found in any species of bacterium.
A system for verifying and maintaining a desired level of quality in a product or process by careful planning, use of proper equipment, continued inspection, and corrective action as required. (Random House Unabridged Dictionary, 2d ed)
A severe condition resulting from bacteria invading healthy muscle from adjacent traumatized muscle or soft tissue. The infection originates in a wound contaminated with bacteria of the genus CLOSTRIDIUM. C. perfringens accounts for the majority of cases (over eighty percent), while C. noyvi, C. septicum, and C. histolyticum cause most of the other cases.
Inorganic compounds that contain phosphorus as an integral part of the molecule.
An acute inflammation of the INTESTINAL MUCOSA that is characterized by the presence of pseudomembranes or plaques in the SMALL INTESTINE (pseudomembranous enteritis) and the LARGE INTESTINE (pseudomembranous colitis). It is commonly associated with antibiotic therapy and CLOSTRIDIUM DIFFICILE colonization.
Personal care items used during MENSTRUATION.
Plugs or cylinders made of cotton, sponge, or other absorbent material. They are used in surgery to absorb fluids such as blood or drainage.
The periodic shedding of the ENDOMETRIUM and associated menstrual bleeding in the MENSTRUAL CYCLE of humans and primates. Menstruation is due to the decline in circulating PROGESTERONE, and occurs at the late LUTEAL PHASE when LUTEOLYSIS of the CORPUS LUTEUM takes place.
Potentially pathogenic bacteria found in nasal membranes, skin, hair follicles, and perineum of warm-blooded animals. They may cause a wide range of infections and intoxications.
Fabric or other material used to cover the body.
Pads made of various materials used for personal hygiene usually for absorbing URINE or FECES. They can be worn as underpants or pants liners by various age groups, from NEWBORNS to the ELDERLY. Absorbent pads can be made of fluff wood pulp and HYDROGEL absorbent covered with viscose rayon, polyester, polypropylene, or POLYETHYLENE coverstock.
The period from onset of one menstrual bleeding (MENSTRUATION) to the next in an ovulating woman or female primate. The menstrual cycle is regulated by endocrine interactions of the HYPOTHALAMUS; the PITUITARY GLAND; the ovaries; and the genital tract. The menstrual cycle is divided by OVULATION into two phases. Based on the endocrine status of the OVARY, there is a FOLLICULAR PHASE and a LUTEAL PHASE. Based on the response in the ENDOMETRIUM, the menstrual cycle is divided into a proliferative and a secretory phase.
Medicines whose effectiveness is unproven and whose ingredients are often secret.
The fraudulent misrepresentation of the diagnosis and treatment of disease.
Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).
Containers, packaging, and packaging materials for drugs and BIOLOGICAL PRODUCTS. These include those in ampule, capsule, tablet, solution or other forms. Packaging includes immediate-containers, secondary-containers, and cartons. In the United States, such packaging is controlled under the Federal Food, Drug, and Cosmetic Act which also stipulates requirements for tamper-resistance and child-resistance. Similar laws govern use elsewhere. (From Code of Federal Regulations, 21 CFR 1 Section 210, 1993) DRUG LABELING is also available.
Substances that reduce the growth or reproduction of BACTERIA.
A generic concept reflecting concern with the modification and enhancement of life attributes, e.g., physical, political, moral and social environment; the overall condition of a human life.
The presence of organisms, or any foreign material that makes a drug preparation impure.
Steroid acids and salts. The primary bile acids are derived from cholesterol in the liver and usually conjugated with glycine or taurine. The secondary bile acids are further modified by bacteria in the intestine. They play an important role in the digestion and absorption of fat. They have also been used pharmacologically, especially in the treatment of gallstones.
A bile acid formed from chenodeoxycholate by bacterial action, usually conjugated with glycine or taurine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is used as cholagogue and choleretic.
A bile acid formed by bacterial action from cholate. It is usually conjugated with glycine or taurine. Deoxycholic acid acts as a detergent to solubilize fats for intestinal absorption, is reabsorbed itself, and is used as a choleretic and detergent.
A publication issued at stated, more or less regular, intervals.
An emulsifying agent produced in the LIVER and secreted into the DUODENUM. Its composition includes BILE ACIDS AND SALTS; CHOLESTEROL; and ELECTROLYTES. It aids DIGESTION of fats in the duodenum.

A phosphatidylserine-binding site in the cytosolic fragment of Clostridium sordellii lethal toxin facilitates glucosylation of membrane-bound Rac and is required for cytotoxicity. (1/28)

Large clostridial toxins glucosylate some small G proteins on a threonine residue, thereby preventing their interactions with effector molecules and regulators. We show that the glucosyltransferase domain of lethal toxin from Clostridium sordellii (LT(cyt); amino acids 1-546), which is released into the cytosol during cell infection, binds preferentially to liposomes containing phosphatidylserine as compared with other anionic lipids. The binding of LT(cyt) to phosphatidylserine increases by two orders of magnitude the rate of glucosylation of liposome-bound geranyl-geranylated Rac-GDP. Limited proteolysis and deletion studies show that the binding site for phosphatidylserine lies within the first 18 N-terminal residues of LT(cyt). Deletion of these residues abolishes the effect of phosphatidylserine on the activity of LT(cyt) on liposome-bound geranyl-geranylated Rac-GDP and prevents the morphological effects induced by LT(cyt) microinjection into various cells, but it does not affect the intrinsic activity of LT(cyt) on non-geranyl-geranylated Rac-GDP in solution. We conclude that the avidity of LT(cyt) for phosphatidylserine facilitates its targeting to the cytosolic leaflet of cell membranes and, notably, the plasma membrane, where this anionic lipid is abundant and where several targets of lethal toxin reside.  (+info)

Clostridium sordellii toxic shock syndrome after medical abortion with mifepristone and intravaginal misoprostol--United States and Canada, 2001-2005. (2/28)

On July 19, 2005, the Food and Drug Administration (FDA) issued a public health advisory regarding the deaths of four women in the United States after medical abortions with Mifeprex (mifepristone, formerly RU-486; Danco Laboratories, New York, New York) and intravaginal misoprostol. Two of these deaths occurred in 2003, one in 2004, and one in 2005. Two of these U.S. cases had clinical illness consistent with toxic shock and had evidence of endometrial infection with Clostridium sordellii, a gram-positive, toxin-forming anaerobic bacteria. In addition, a fatal case of C. sordellii toxic shock syndrome after medical abortion with mifepristone and misoprostol was reported in 2001, in Canada. All three cases of C. sordellii infection were notable for lack of fever, and all had refractory hypotension, multiple effusions, hemoconcentration, and a profound leukocytosis. C. sordellii previously has been described as a cause of pregnancy-associated toxic shock syndrome.  (+info)

Fatal toxic shock syndrome associated with Clostridium sordellii after medical abortion. (3/28)

Endometritis and toxic shock syndrome associated with Clostridium sordellii have previously been reported after childbirth and, in one case, after medical abortion. We describe four deaths due to endometritis and toxic shock syndrome associated with C. sordellii that occurred within one week after medically induced abortions. Clinical findings included tachycardia, hypotension, edema, hemoconcentration, profound leukocytosis, and absence of fever. These cases indicate the need for physician awareness of this syndrome and for further study of its association with medical abortion.  (+info)

Sudden death associated with Clostridium sordellii in captive lions (Panthera leo). (4/28)

In the spring of 2003, a series of sudden deaths in a group of adult lions (Panthera leo) with a previous history of depression, inanition, and lethargy, was investigated. Five animals died within 24 to 36 hours after onset of signs of disease. Serologic screening for viral disease detection was negative, evidence of parasites was not detected, and results of a complete blood count and serum biochemical analysis were within reference intervals in all lions. The most relevant lesions observed were multiple areas of necrosis and hemorrhage in the intestinal outer muscular layer, and cellulitis with an intense bloody edema in the mesenteric and the pericardial fat tissue. On the basis of the fulminant course of the disease, the gross and histologic findings, and the isolation and identification of Clostridium sordellii, a diagnosis of infectious myositis and cellulitis associated with acute clostridiosis was made. To the authors' knowledge, this is the first report of sudden death associated with C. sordellii in felines.  (+info)

Clostridium sordellii infection: epidemiology, clinical findings, and current perspectives on diagnosis and treatment. (5/28)

Clostridium sordellii infections pose difficult clinical challenges and are usually fatal. Most commonly, these infections occur after trauma, childbirth, and routine gynecological procedures, but they have recently been associated with medically induced abortions and injection drug use. We report 2 fatal cases, one of which was associated with minor trauma, and the other of which was associated with normal childbirth, and we summarize the clinical features of 43 additional cases of reported C. sordellii infection. Of these 45 cases, 8 (18%) were associated with normal childbirth, 5 (11%) were associated with medically induced abortion, and 2 (0.4%) were associated with spontaneous abortion. The case-fatality rate was 100% in these groups. Ten (22%) of the C. sordellii infections occurred in injection drug users, and 50% of these patients died. Other cases of C. sordellii infection (in 19 patients [43%]) occurred after trauma or surgery, mostly in healthy persons, and 53% these patients died. Overall, the mortality rate was 69% (31 of 45 patients). Eighty-five percent of all patients with fatal cases died within 2-6 days of initial infection, and nearly 80% of fatal cases developed leukemoid reactions. Rapid diagnostic tests and improved treatments are needed to reduced the morbidity and mortality associated with this devastating infection.  (+info)

Infection of internal umbilical remnant in foals by Clostridium sordellii. (6/28)

Omphalitis and the resulting septicemia contribute to perinatal mortality in several animal species. In foals, the most important causes of omphalitis are Escherichia coli and Streptococcus zooepidemicus. However to date, no information has been published about the role of Clostridium sordellii in these infections. In this paper, we describe 8 cases of perinatal mortality in foals associated with internal umbilical remnant infection by C. sordellii. The foals studied were between 12 and 21 days old at the time of death, and various breeds were represented in the group. Five of the foals were male and 3 were female. The diagnosis was established on the basis of the detection of C. sordellii by 3 methods (culture, fluorescent antibody test, and immunohistochemistry) and on gross and histopathologic findings. All foals had acute peritonitis, and the internal umbilical remnant was thickened by edema, hemorrhage, and fibrosis. A moderate amount of serosanguinous fluid with fibrin strands was present in the pericardial sac and pleural cavity. Histopathologically, the urachus and umbilical arterial walls were thickened by edema and exhibited hemorrhage, fibrin, and leukocytic infiltration. Gram-positive bacterial rods were observed in subepithelial areas of the urachus, the adventicia of umbilical arteries, and interstitium of the internal umbilical remnant. On the basis of these findings, we suggest that C. sordellii should be considered in the differential diagnosis for infections of the internal umbilical remnant in foals.  (+info)

The leukemoid reaction in Clostridium sordellii infection: neuraminidase induction of promyelocytic cell proliferation. (7/28)

Life-threatening Clostridium sordellii infections have recently been reported in women undergoing therapeutic abortion, during natural childbirth, and in injection drug users. Shock, diffuse capillary leak, and a leukemoid reaction (LR) are cardinal features of these infections. The magnitude of the LR is highly correlated with mortality. We have isolated a 42-kDa extractable protein from C. sordellii culture supernatant that stimulates proliferation of promyelocytic HL-60 cells in vitro. Using mass spectrometry, we have identified this protein as the C. sordellii neuraminidase, NanS. Recombinant NanS (rNanS) dose dependently stimulated HL-60 cell proliferation. Increased proliferation was observed when HL-60 cells were cocultured with both rNanS and granulocyte-macrophage colony stimulating factor. In addition, NanS also modified vascular cell adhesion molecule 1, which orchestrates the release of mature and immature granulocytes from bone marrow stromal cells. Thus, neuraminidase likely plays an important role in the characteristic LR in C. sordellii infection.  (+info)

The large clostridial toxins from Clostridium sordellii and C. difficile repress glucocorticoid receptor activity. (8/28)

We have previously shown that Bacillus anthracis lethal toxin represses glucocorticoid receptor (GR) transactivation. We now report that repression of GR activity also occurs with the large clostridial toxins produced by Clostridium sordellii and C. difficile. This was demonstrated using a transient transfection assay system for GR transactivation. We also report that C. sordellii lethal toxin inhibited GR function in an ex vivo assay, where toxin reduced the dexamethasone suppression of the proinflammatory cytokine tumor necrosis factor alpha (TNF-alpha). Furthermore, the glucocorticoid antagonist RU-486 in combination with C. sordellii lethal toxin additively prevented glucocorticoid suppression of TNF-alpha. These findings corroborate the fact that GR is a target for the toxin and suggest a physiological role for toxin-associated GR repression in inflammation. Finally, we show that this repression is associated with toxins that inactivate p38 mitogen-activated protein kinase (MAPK).  (+info)

Clostridium sordellii infections pose difficult clinical challenges and are usually fatal. Most commonly, these infections occur after trauma, childbirth, and routine gynecological procedures, but they have recently been associated with medically induced abortions and injection drug use. We report 2 …
Post-abortion infection is not well defined as one particular type of infection in studies of medical abortion 33 . The most common type of infection reported is endometritis, which is an infection of the lining of the uterus, and genital tract. It may involve infection of reproductive organs and the urinary system. Clostridium sordellii sepsis is another type of post-abortion infection that is extremely rare. Doctors analyzed one case in which a woman died from complications associated with Clostridium sordellii infection, and determined that even though the infection was associated with medical abortion, the case does not alter the overall proven safety of medical abortions induced with Mifepristone and Misoprostol 11 . Clostridium sordellii can also cause fatal infections in women who have just given birth 39 . It is not an infection that only affects women having medical abortions.. Clostridium sordellii specifically called attention to the somewhat unusual and rather distinctive signs and ...
Clostridium difficile and C. sordellii are two anaerobic, spore forming, gram positive pathogens with a broad host range and the ability to cause lethal infections. Despite strong similarities between the two Clostridial strains, differences in their host tissue preference place C. difficile infections in the gastrointestinal tract and C. sordellii infections in soft tissues. In this study, to improve our understanding of C. sordellii and C. difficile virulence and pathogenesis, we have performed a comparative genomic and phenomic analysis of the two. The global phenomes of C. difficile and C. sordellii were compared using Biolog Phenotype microarrays. When compared to C. difficile, C. sordellii was found to better utilize more complex sources of carbon and nitrogen, including peptides. Phenotype microarray comparison also revealed that C. sordellii was better able to grow in acidic pH conditions. Using next generation sequencing technology, we determined the draft genome of C.
Lethal Toxin from Clostridium sordellii (TcsL), which is casually involved in the toxic shock syndrome and in gas gangrene, enters its target cells by receptor-mediated endocytosis. Inside the cell, TcsL mono-O-glucosylates and thereby inactivates Rac/Cdc42 and Ras subtype GTPases, resulting in actin reorganization and an activation of p38 MAP kinase. While a role of p38 MAP kinase in TcsL-induced cell death is well established, data on a role of p38 MAP kinase in TcsL-induced actin reorganization are not available. In this study, TcsL-induced Rac/Cdc42 glucosylation and actin reorganization are differentially analyzed in p38alpha−/− MSCV empty vector MEFs and the corresponding cell line with reconstituted p38alpha expression (p38alpha−/− MSCV p38alpha MEFs). Genetic deletion of p38alpha results in reduced susceptibility of cells to TcsL-induced Rac/Cdc42 glucosylation and actin reorganization. Furthermore, SB203580, a pyridinyl imidazole inhibitor of p38alpha/beta MAP kinase, also protects
Clostridium sordellii ATCC ® 9714™ Designation: 211 TypeStrain=True Application: Quality control strain Control strain for anaerobe identification Quality control strain for API, BBL, IDS, and MicroScan [Reg TM] products
Clostridium sordellii ATCC ® 9714™ Designation: 211 TypeStrain=True Application: Quality control strain Control strain for anaerobe identification Quality control strain for API, BBL, IDS, and MicroScan [Reg TM] products
Achilles, S. L., & Reeves, M. F. (2011). Society of Family Planning Clinical Guideline 20102: Prevention of infection after induced abortion. Contraception, 83(4), 295-309.. American College of Obstetricians and Gynecologists. (2014). Practice Bulletin No. 143: Medical management of first-trimester abortion. Obstetrics & Gynecology, 123(3), 676-692.. Chen, M. J., & Creinin, M. D. (2015). Mifepristone with buccal misoprostol for medical abortion: A systematic review. Obstetrics & Gynecology, 126(1), 12-21.. Cohen, A. L., Bhatnagar, J., Reagan, S., Zane, S. B., DAngeli, M. A., Fischer, M., … McDonald, L. C. (2007). Toxic shock associated with Clostridium sordellii and Clostridium perfringens after medical and spontaneous abortion. Obstetrics & Gynecology, 110(5), 1027-1033.. Fischer, M., Bhatnagar, J., Guarner, J., Reagan, S., Hacker, J. K., Van Meter, S. H., & Zaki, S. R. (2005). Fatal toxic shock syndrome associated with Clostridium sordellii after medical abortion. New England Journal of ...
Definition of clostridial toxin in the Financial Dictionary - by Free online English dictionary and encyclopedia. What is clostridial toxin? Meaning of clostridial toxin as a finance term. What does clostridial toxin mean in finance?
The Minnesota Department of Health (MDOH) has received reports of three previously healthy persons who died unexpectedly following uncomplicated knee surgery; two had total knee replacements and one had a cartilage graft implantation. The surgeries were performed at two local hospitals. Two patients died on November 11, 2001, and one died on November 16, approximately 36--82 hours following surgery. CDC is assisting MDOH in the investigation of these events. All three patients became ill 1--4 days following surgery. Symptoms included severe abdominal pain and a sudden decline in blood pressure followed by a fulminant course with death within 24 hours of symptom onset. The clinical course was consistent with septic or cardiogenic shock. After 5 days of incubation, a blood culture taken from one of the patients yielded Clostridium sordellii. The source of infection in the one patient and the cause of death in all patients remain unknown. In response to these deaths, MDOH is recommending that all ...
Protokół aborcji farmakologicznej w Kanadzie obejmuje metotreksat i mizoprostol. Mifepriston nie został w tym celu zarejestrowany i obecnie nie jest legalnie dostępny. Od 2000 roku w różnych miastach kanadyjskich odbywały się testy kliniczne z użyciem obydwu schematów terapeutycznych, które nie wykazały różnic w ich skuteczności (mifepriston miał mieć szybszy początek działania). Rok później wstrzymano jednak postępowanie legalizacyjne, kiedy jedna z pacjentek zmarła na skutek uogólnionego zakażenia bakterią Clostridium sordellii[82]. Użycie mifepristonu w Australii zostało zakazane w 1996 roku. Pod koniec 2005 roku Senat Australii zajął się ustawą poselską, która znosiła to ograniczenie i przekazywała moc decyzyjną Therapeutic Goods Administration (TGA), instytucji odpowiedzialnej za nadzór nad środkami farmaceutycznymi. Wniosek wywołał wiele kontrowersji na terenie całego kraju. 10 lutego 2006 roku prawo zostało uchwalone i od tej pory mifepriston ...
Rectal biopsies were maintained in organ culture over a 24-hour culture period, with good preservation of histological architecture. A filtrate containing Clostridium difficile toxin significantly inhibited the rise in epithelial alkaline phosphatase activity normally seen during culture. This effect was abolished by pre-incubation of the filtrate with Clostridium sordellii antitoxin, or heat inactivation. This effect is most probably due to a toxin of C. difficile. The method provides a new quantitative approach to the study of luminal toxins as possible pathogenic agents in idiopathic inflammatory diseases of the colon.
Clostridium difficile is an important nosocomial pathogen, resulting in antibiotic-associated disease ranging from mild diarrhoea to the life-threatening pseudomembranous colitis. Upon antibiotic exposure, it is believed that the normal bowel microflora of patients is disrupted, allowing C. difficile to proliferate. Significantly, C. difficile is among only a few bacteria able to ferment tyrosine to p-cresol, a phenolic compound that is toxic to other microbes via its ability to interfere with metabolism. Therefore, the ability of different C. difficile strains to produce and tolerate p-cresol may play an important role in the development and severity of C. difficile-associated disease. In this study, it was demonstrated that two C. difficile hypervirulent 027 strains (Stoke Mandeville and BI-16) are more tolerant to p-cresol than other C. difficile strains including 630, CF4 and CD196. Surprising, it was shown that Clostridium sordellii also has a high tolerance to p-cresol, suggesting an overlap in
Agents for treating pain, methods for producing the agents and methods for treating pain by administration to a patient of a therapeutically effective amount of the agent. The agent can include a clostridial neurotoxin, or a component or fragment or derivative thereof, attached to a targeting moiety, wherein the targeting moiety is selected from a group consisting of transmission compounds which can be released from neurons upon the transmission of pain signals by the neurons, and compounds substantially similar to the transmission compounds.
Methods for treating fibromyalgia may include administering a therapeutically effective amount of a Clostridial toxin to a peripheral location on the body of a patient. This peripheral location is other than the site on the body where the pain emanates.
Extreme leukocytosis and leukemoid reaction associated with the lung sarcomatoid carcinoma: an unusual case report Danyang Wang, Haiyan Zhang, Fengkuan Yu, Baijun Fang Department of Hematopathy, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, People’s Republic of China Purpose: To report a rare case of extreme leukocytosis and leukemoid reaction associated with lung sarcomatoid carcinoma (LSC) and increase people’s awareness of the disease. Patients and methods: A 58-year-old male patient was diagnosed with LSC; however, after the end of the second course of chemotherapy, his white blood cells increased gradually without fever or use of medications such as granulocyte colony-stimulating factor and steroids. A bone marrow biopsy then confirmed it to be a leukemoid reaction. Results: The patient died of multiple organ failure 2 months after being diagnosed with leukocytosis. Conclusion: LSC associated with leukemoid reaction is very rare and the prognosis is
A successful pregnancy requires that the maternal immune system adapts to tolerate the semi-allogeneic fetal-placental unit. This adaptation mainly occurs locally, i.e. at the fetal-maternal interface, where fetal-derived tissues come into close contact with maternal cells in the uterine endometrium (called decidua during pregnancy). Macrophages and regulatory T (Treg) cells are maternal immune cells that are enriched in the decidua and they likely play a central role in promoting fetal tolerance. However, the precise function of decidual macrophages and the factors regulating both macrophages and Treg cells in humans are unknown. The aim of this thesis was to characterize the phenotype and function of decidual macrophages from first trimester human pregnancy and to identify factors responsible for inducing tolerogenic properties in both decidual macrophages and Treg cells. CD14+ decidual macrophages showed characteristics of immune suppressive or homeostatic macrophages (expression of CD163, ...
Paraneoplastic leukemoid reaction is rare in patients with primary pancreatic cancer. In literature review, we found only five previous cases of a leukemoid reaction in patients with pancreatic cancer.5, 6, 7, 8, 9 In 1971, Akoun et al.7 described the first case of myeloid leukemoid reaction in a pancreatic cancer patient. Since then, four cases with leukemoid reaction associated with pancreatic cancer have been reported.6, 7, 8, 9 This case, to the best of our knowledge, is the first case reporting the paraneoplastic leukemoid reaction with pancreatic cancer in Korea.. Paraneoplastic leukemoid reaction is diagnosed by excluding other secondary causes.4 In our patient, catheter-related infection was suspected during the early admission period but leukocytosis worsened after proper treatment for the infection. Multiple follow up blood cultures were negative, and further workups for infectious etiology were negative as well. Leukemoid reactions in advanced malignancy are mostly myelocytic. On the ...
Leukemoid reaction with pulmonary carcinoma has been a rare observation. Three cases are presented in detail with possible mechanisms contributing to the production of a leukemoid blood picture.
Conference Comment: The contributor provides a good summary of C. piliforme, an atypical member of the genus Clostridium. Other members of the clostridia are large, Gram positive spore forming bacteria with straight or slightly curved morphology, in contrast the filamentous, Gram negative spore forming C. piliforme.(2) Further differentiating C. piliforme from other clostridia is the fact that it does not possess characteristics that allow its inclusion into one of the three general categories of the other pathogenic members of the genus. These categories of clostridia are neurotoxic (C. tetani, C. botulinum types A-G), histotoxic (C. chauvoei, C. septicum, C. novyi types A and B, C. perfringens type A, C. sordellii, C. hemolyticum), and enteropathogenic/enterotoxemia-producing (C. perfringens types A-E, C. difficile, C. colinum, C. spiroforme).(2 ...
For use in healthy cattle and calves three months of age or older as an aid in preventing blackleg caused by Clostridium chauvoei, malignant edema caused by Cl. septicum, black disease caused by Cl. novyi, gas-gangrene caused by Cl. sordellii, enterotoxemia and enteritis caused by Cl. perfringens Types B, C and D, and disease caused by Histophilus somni (Haemophilus somnus). Although Cl. perfringens Type B is not a significant problem in North America, immunity is provided by the beta toxoid of Type C and the epsilon toxoid of Type D. Ultrabac 7/Somubac consists of killed, standardized cultures of Cl. chauvoei, Cl. septicum, Cl. novyi, Cl. sordellii, Cl. perfringens Types C and D, and H. somni, with an adjuvant. Available in a 10 dose or 50 dose.. ...
A leukemoid reaction (LR) is a hematological disorder, defined by a leukocyte count greater than 50,000 cells/mcL with reactive causes outside the bone ...
Decidual macrophages (DM) are the second most abundant population in the fetal-maternal interface. Their role has been so far identified as being local immuno-modulators favoring the maternal tolerance to the fetus. Herein we investigated tissue samples from 11 cases of spontaneous miscarriages and from 9 cases of elective terminations of pregnancy. Using immunohistochemistry and dual immunofluorescence we have demonstrated that in spontaneous miscarriages the DM are significantly increased. Additionally, we noted a significant up-regulation of macrophage FasL expression. Our results further support a dual role for DM during pregnancy and miscarriages. We hypothesize that the baseline DM population in normal pregnancy is in line with an M2 phenotype supporting the ongoing gestation. In contrast, during spontaneous miscarriages, the increased FasL-expressing population could be a part of an M1 phenotype participating in Fas/FasL-related apoptosis. Our results highlight a new aspect of macrophage biology
One Shot Ultra 8 Cattle Vaccine aids in the prevention of blackleg, malignant edema, bacilary hemoglobinuria, black disease, enterotoxemia and enteritis, and bovine pneumonia.
Methods have been developed for isolating human tissue macrophages from first trimester or term pregnancy decidua. After a two stage enzymic digestion, viable cells were separated from cellular debris by velocity sedimentation at unit gravity or by Percoll centrifugation. Cell populations were analysed by flow cytometry after labelling with monoclonal antibodies. In term decidua, 47% of the cells were of bone marrow origin, comprising 18% macrophages, 3% large granular lymphocytes and 8% T cells. The remaining cells, the proportion of which varied between individuals, were CD16-positive granulocytes. Macrophages were isolated flow cytometrically from both first trimester and term decidual cell dispersions after labelling with an antibody to MHC class II. Yields of up to 4 X 10(6) macrophages, greater than 95% pure, were routinely obtained.
For use in healthy cattle and sheep as an aid in preventing disease caused by Clostridium chauvoei (Blackleg), septicum (Malignant edema), haemolyticum (Bacilliary Hemoglobinuria (Red Water)), novyl (Black disease), sordellii and perfringens Types C&D (Enterotoxemia).
Supplementary Materialsijms-20-05994-s001. immune responses [15,16,17]. In addition, is usually up-regulated in the endometrial cells of pregnant women compared to non-pregnant women [18]. Up-regulated had been found in both the nucleus and cytoplasm in the decidual stromal cells of human first-trimester endometrium [18]. In an in vitro decidualization model, was up-regulated and only the short isoform translocated to the nucleus of endometrial stromal cells [18]. Given these facts, we were thinking about exploring the hyperlink between your macrophage and gene polarization in individual deciduas. Investigations of decidual macrophages polarity and stability may help to clarify their jobs in pregnancies and could pave the best way to therapies of pathological pregnancies. 2. Outcomes 2.1. NLRP7 Portrayed in Decidual Macrophages from the First-Trimester Being pregnant Our previous research discovered that may donate to the decidualization of endometrial stromal cells [18]. We continued to explore ...
Lauren Wesser who had her leg amputed due to a a rare tampon infection now educates girls about Toxic Shock Syndrome. | This model lost her leg to Toxic Shock Syndrome. What is it?
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Toxic Shock Syndrome is most often caused by staphylococcal bacterial toxins, but streptococcal bacteria can cause a similar illness.
ICD-10 A48.3 is toxic shock syndrome (A483). This code is grouped under diagnosis codes for certain infectious and parasitic diseases.
Wearing the same tampon for an extended amount of time could lead to a rare, but sometimes deadly disease called toxic shock syndrome (TSS). The National Women
Mum Lou Harvey-Smith revealed her sons terrifying ordeal after contracting Toxic Shock Syndrome after burning himself - only to be misdiagnosed...
Researchers from the University of Maryland School of Medicine and their colleagues have identified the structure of the most lethal toxin produced by certain strains of Clostridium difficile bacteria, a potentially deadly infection associated with the use of antibiotics. The
a b Cohen AL, Bhatnagar J. Toxic shock associated with Clostridium sordellii and Clostridium perfringens after medical and ... Fatal Clostridium sordellii Infections after Medical Abortions. „N Engl J Med", s. 1382-1383, 2010-09-30 (ang.). ... Clostridium sordellii to Gram-dodatnia laseczka, kolonizująca drogi rodne u 0,5-10% kobiet. Bywa ona sporadycznie przyczyną ... Pathophysiology of mifepristone-induced septic shock due to Clostridium sordellii. „Ann Pharmacother". 39 (9), s. 1483-1488, ...
Schamber, G.J.; Berg, I.E.; Molesworth, J.R. (April 1986). "Braxy or Bradsot-like Abomastitis Caused by Clostridium septicum in ... sordellii, and Sarcina spp.) Viruses like Rinderpest morbillivirus or Pestivirus can also cause an inflammation of the mucosa, ... Abomasitis can be caused by several factors: Bacterial infections (e.g. Clostridium septicum, C. perfringens (type A), C. ...
Clostridium species involved are Clostridium perfringens, Clostridium septicum, and Clostridium sordellii, which typically ... Clostridium sordellii can also produce two major toxins: all known virulent strains produce the essential virulence factor ... The key Clostridium septicum virulence factor is a pore-forming toxin called alpha-toxin, though it is unrelated to the ... Bacteroides and Clostridium species). Populations of those affected are typically older with medical comorbidities such as ...
pH-dependent channel formation has been demonstrated for C. difficile Toxin B and C as well as Clostridium sordellii lethal ... Clostridium difficile toxin B Clostridium difficile colitis Clostridium difficile (bacteria) RTX toxin Transporter ... Pruitt RN, Chambers MG, Ng KK, Ohi MD, Lacy DB (July 2010). "Structural organization of the functional domains of Clostridium ... Clostridium difficile, the causative agent of nosocomial antibiotic-associated diarrhea and pseudomembranous colitis, possesses ...
... schirmacherense Clostridium scindens Clostridium septicum Clostridium sordellii Clostridium sphenoides Clostridium ... Clostridium aceticum Clostridium acetireducens Clostridium acetobutylicum Clostridium acidisoli Clostridium aciditolerans ... Clostridium acidurici Clostridium aerotolerans Clostridium aestuarii Clostridium akagii Clostridium aldenense Clostridium ... difficile Clostridium diolis Clostridium disporicum Clostridium drakei Clostridium durum Clostridium estertheticum Clostridium ...
Just I, Selzer J, Hofmann F, Green GA, Aktories K (April 1996). "Inactivation of Ras by Clostridium sordellii lethal toxin- ... Some authors include Clostridium haemolyticum as Clostridium novyi type D. C novyi is closely related to Clostridium botulinum ... toxins of Clostridium difficile show homology with the alpha-toxin of C novyi as does the lethal toxin of clostridium sordellii ... Clostridium novyi (oedematiens) a Gram-positive, endospore- forming, obligate anaerobic bacteria of the class clostridia. It is ...
McGregor.pdf Pathema-Clostridium Resource Type strain of Clostridium sordellii at BacDive - the Bacterial Diversity ... Clostridium sordellii is a rare anaerobic, gram-positive, spore-forming rod with peritrichous flagella that is capable of ... M. J. Aldape, A. E. Bryant, D. L. Stevens; Clostridium sordellii Infection: Epidemiology, Clinical Findings, and Current ... C. sordellii bacteremia and sepsis occur rarely. Most cases of sepsis from C. sordellii occur in patients with underlying ...
These bacterial toxins have been shown to be associated with Clostridium sordellii hemorrhagic toxin (TcsH), lethal toxin (TcsL ... Clostridium difficile toxin B is a cytotoxin produced by the bacteria Clostridium difficile. It is one of two major kinds of ... Clostridium difficile TcdE Holin Holin Reinert DJ, Jank T, Aktories K, Schulz GE (September 2005). "Structural basis for the ... With regard to Clostridium difficile-associated diarrhea (CDAD), the effects of cytopathicity are more critical than actual ...
Clostridium haemolyticum Clostridium novyi Clostridium perfringens Clostridium septicum Clostridium sordellii Clostridium ... Clostridial vaccines can contain anti-toxins to one or more endotoxins produced by the following bacteria: Clostridium chauvoei ... for sheep and cattle that protects against diseases caused by toxins produced by an infection with one or more Clostridium ...
Včasih je s C. botulinum okužen med in takšen med lahko pri otrocih povzroči botulizem.[2] C. sordellii so povezali z nekaj več ... Clostridium (klostridij) je rod grampozitivnih bakterij iz debla Firmicutes. Bakterije iz tega rodu so obvezni anaerobi in ... V rod Clostridium spadajo tako nenevarne vrste kot tudi pomembni patogeni. Štiri vrste povzročajo pri človeku bolezni: *C. ... Vzpostavljeno iz »https://sl.wikipedia.org/w/index.php?title=Clostridium&oldid=4843481« ...
Clostridium perfringens MeSH B03.300.390.400.200.700 - Clostridium sordellii MeSH B03.300.390.400.200.710 - Clostridium ... Clostridium perfringens MeSH B03.510.415.400.200.700 - Clostridium sordellii MeSH B03.510.415.400.200.710 - Clostridium ... Clostridium botulinum type G MeSH B03.300.390.400.200.180 - Clostridium butyricum MeSH B03.300.390.400.200.200 - Clostridium ... Clostridium botulinum type G MeSH B03.510.415.400.200.180 - Clostridium butyricum MeSH B03.510.415.400.200.200 - Clostridium ...
General Information about C. sordellii. Clostridium sordellii [klaw-strĭ-dee-um sore-dell-ee-i] (also called C. sordellii) is a ... Toxic shock associated with clostridium sordellii and clostridium perfringens after medical and spontaneous abortion.external ... It is not known how C. sordellii is spread between persons or from the environment to persons. Other similar Clostridium ... For more information see the Clostridium sordellii Toxic Shock Syndrome After Medical Abortion with Mifepristone and ...
McGregor.pdf Pathema-Clostridium Resource Type strain of Clostridium sordellii at BacDive - the Bacterial Diversity ... Clostridium sordellii is a rare anaerobic, gram-positive, spore-forming rod with peritrichous flagella that is capable of ... M. J. Aldape, A. E. Bryant, D. L. Stevens; Clostridium sordellii Infection: Epidemiology, Clinical Findings, and Current ... C. sordellii bacteremia and sepsis occur rarely. Most cases of sepsis from C. sordellii occur in patients with underlying ...
Clostridium sordellii synonyms, Clostridium sordellii pronunciation, Clostridium sordellii translation, English dictionary ... definition of Clostridium sordellii. n. pl. clos·trid·i·a Any of various rod-shaped, spore-forming, chiefly anaerobic bacteria ... of the genus Clostridium, such as certain nitrogen-fixing species... ... Clostridium chauvoei, Clostridium septicum, Clostridium perfringens, Clostridium novyi, Clostridium Sordellii, por exemplo, ...
In 1927 the organism was renamed Bacillus sordellii and two years later it became classified as Clostridium sordellii, as it is ... In women, the C. sordellii infection can develop into Clostridium sordellii Toxic Shock Sydrome (CSTS), which is associated ... The mechanism of transmission for Clostridium sordellii between person to person or person to environment is not known [2]. ... A study published by The American Journal of Pathology investigated the effects of Clostridium sordellii in mice. The lethal ...
Clostridium sordellii ATCC ® 9714™ Designation: 211 TypeStrain=True Application: Quality control strain Control strain for ... Nucleotide (GenBank) : M59105 Clostridium sordellii 16S ribosomal RNA. Nucleotide (GenBank) : L12058 Clostridium sordellii 7- ... Clostridium sordellii (Hall and Scott) Prevot (ATCC® 9714™) Strain Designations: 211 [NCIB 10717] / Type Strain: yes / ... Clostridium sordellii (Hall and Scott) Prevot (ATCC® 9714-MINI-PACK™) Add to ...
Clostridium sordellii infections pose difficult clinical challenges and are usually fatal. Most commonly, these infections ... Clostridium sordellii infection: epidemiology, clinical findings, and current perspectives on diagnosis and treatment Clin ... Clostridium sordellii infections pose difficult clinical challenges and are usually fatal. Most commonly, these infections ... Ten (22%) of the C. sordellii infections occurred in injection drug users, and 50% of these patients died. Other cases of C. ...
Requirements for Germination of Clostridium sordellii Spores In Vitro Message Subject (Your Name) has forwarded a page to you ... Requirements for Germination of Clostridium sordellii Spores In Vitro. Norma Ramirez, Ernesto Abel-Santos ... Clostridium sordellii is a spore-forming, obligately anaerobic, Gram-positive bacterium that can cause toxic shock syndrome ... C. sordellii spores germinated only in a narrow pH range between 5.7 and 6.5. In contrast, C. sordellii spore germination was ...
We describe four deaths due to endometritis and toxic shock syndrome associated with C. sordellii that occurred within one week ... Endometritis and toxic shock syndrome associated with Clostridium sordellii have previously been reported after childbirth and ... Fatal toxic shock syndrome associated with Clostridium sordellii after medical abortion N Engl J Med. 2005 Dec 1;353(22):2352- ... Endometritis and toxic shock syndrome associated with Clostridium sordellii have previously been reported after childbirth and ...
Clostridium sordellii, ATCC-9714, from Microorganisms. High-quality, certified reference materials, available to purchase ...
Clostridium sordellii lethal toxin (TcsL) is a powerful virulence factor responsible for severe toxic shock in man and animals ... Keywords: Clostridium sordellii; Clostridium difficile; large clostridial glucosylating toxin; C. sordellii lethal toxin; ... This article belongs to the Collection Clostridium difficile/Clostridium sordellii and Clostridium perfringens Toxins) ... Ras Clostridium sordellii; Clostridium difficile; large clostridial glucosylating toxin; C. sordellii lethal toxin; ...
Lethal Toxin from Clostridium sordellii (TcsL), which is casually involved in the toxic shock syndrome and in gas gangrene, ... Role of p38alpha/beta MAP Kinase in Cell Susceptibility to Clostridium sordellii Lethal Toxin and Clostridium difficile Toxin B ... "Role of p38alpha/beta MAP Kinase in Cell Susceptibility to Clostridium sordellii Lethal Toxin and Clostridium difficile Toxin B ... Role of p38alpha/beta MAP Kinase in Cell Susceptibility to Clostridium sordellii Lethal Toxin and Clostridium difficile Toxin B ...
Severe capillary leakage, toxic shock syndrome, and an extreme leukemoid reaction (LR), are hallmark features of C. sordellii ... Clostridium sordellii is a lethal pathogen for both animals and humans. ... Clostridium sordellii is a lethal pathogen for both animals and humans. Severe capillary leakage, toxic shock syndrome, and an ... Follow-up in vitro and in vivo work is under way to further characterize Mcs1 enzymatic kinetics and its role in C. sordellii ...
Tetracycline-resistance genes of Clostridium perfringens, Clostridium septicum and Clostridium sordellii isolated from cattle ... Toxic shock associated with Clostridium sordellii and Clostridium perfringens after medical and spontaneous abortion. Obstet ... Clostridium sordellii in enteritis in an adult sheep. Vet Rec 112:19. doi:10.1136/vr.112.1.19. ... Clostridium sordellii lethal toxin kills mice by inducing a major increase in lung vascular permeability. Am J Pathol 170:1003- ...
Purification and characterization of Clostridium sordellii lethal toxin and cross-reactivity with Clostridium difficile ... Purification and characterization of Clostridium sordellii lethal toxin and cross-reactivity with Clostridium difficile ... Purification and characterization of Clostridium sordellii lethal toxin and cross-reactivity with Clostridium difficile ... Purification and characterization of Clostridium sordellii lethal toxin and cross-reactivity with Clostridium difficile ...
Clostridium sordellii and C. septicum posses susceptibility similar to C. perfringens, although there are occasional strains ... Clostridium innocuum and Clostridium ramosen compared with these of clinical isolates of Clostridium perfringens. J Clin ... by Clostridium sporogenes, Clostridium novyi and Clostridium botulinum (14). ... Clostridium sordellii bacteremia: case report and review. Clin Infect Dis. 1992;15:950-4. [PubMed] ...
Clostridium sordellii Lethal-Toxin Autoprocessing and Membrane Localization Activities Drive GTPase Glucosylation Profiles in ... Clostridium sordellii Lethal-Toxin Autoprocessing and Membrane Localization Activities Drive GTPase Glucosylation Profiles in ... Clostridium sordellii Lethal-Toxin Autoprocessing and Membrane Localization Activities Drive GTPase Glucosylation Profiles in ... Clostridium sordellii Lethal-Toxin Autoprocessing and Membrane Localization Activities Drive GTPase Glucosylation Profiles in ...
The lethal toxin (LT) from Clostridium sordellii, which belongs to the family of large clostridial cytotoxins, acts as a ... The lethal toxin (LT) from Clostridium sordellii, which belongs to the family of large clostridial cytotoxins, acts as a ... Glucosylation of Ras by Clostridium sordellii lethal toxin: consequences for effector loop conformations observed by NMR ... Glucosylation of Ras by Clostridium sordellii lethal toxin: consequences for effector loop conformations observed by NMR ...
... sordellii infections in soft tissues. In this study, to improve our understanding of C. sordellii and C. difficile virulence ... When compared to C. difficile, C. sordellii was found to better utilize more complex sources of carbon and nitrogen, including ... Phenotype microarray comparison also revealed that C. sordellii was better able to grow in acidic pH conditions. Using next ... Proteins involved in the metabolic differences between C. sordellii and C. difficile should be targets for further studies ...
Glucosylation of Ras by Clostridium sordellii Lethal Toxin: Consequences for Effector Loop Conformations Observed by NMR ...
... * General information. *. the following information is not yet verified. Taxonomy. Family: ... Most cases of sepsis from C. sordellii occur in patients with underlying conditions.. Severe toxic shock syndrome among ... previously healthy persons has been described in a small number of C. sordellii cases, most often associated with gynecologic ...
Clostridium sordellii (C. sordellii). These bacteria normally exist in the vagina and dont cause infection. They may enter the ... It can be caused by Staphylococcus aureus, Streptococcus pyogenes, or Clostridium sordellii. ... Intravenous drug use can also cause C. sordellii infections.. Who is at risk for toxic shock syndrome?. You may be at risk for ...
Clostridium sordellii lethal toxin reproduces the fatal toxic shock syndrome observed in humans and animals ... Clostridium sordellii lethal toxin kills mice by inducing a major increase in lung vascular permeability. ... When intraperitoneally injected into Swiss mice, Clostridium sordellii lethal toxin reproduces the fatal toxic shock syndrome ...
keywords = "chicken, Clostridium perfringens, Clostridium sordellii, necrotic enteritis, poultry",. author = "Guillermo Rimoldi ... These rods were identified as C. sordellii by immunohistochemistry. Clostridium sordellii was isolated in an almost pure ... These rods were identified as C. sordellii by immunohistochemistry. Clostridium sordellii was isolated in an almost pure ... These rods were identified as C. sordellii by immunohistochemistry. Clostridium sordellii was isolated in an almost pure ...
Clostridium sordellii Remove constraint Subject: Clostridium sordellii Subject skeletal muscle Remove constraint Subject: ... 1. Lethal toxin of Clostridium sordellii is associated with fatal equine atypical myopathy ... horses; Clostridium sordellii; bacterial infections; horse diseases; bacterial toxins; septic shock; mortality; myocardial ... The lethal toxin of Clostridium sordellii (TcsL) evokes severe, mostly fatal disease patterns like toxic shock syndrome in ...
... information resources and questions answered by our Genetic and Rare Diseases Information Specialists for Clostridium sordellii ... ClinicalTrials.gov lists trials that are related to Clostridium sordellii infection. Click on the link to go to ClinicalTrials. ... PubMed is a searchable database of medical literature and lists journal articles that discuss Clostridium sordellii infection. ... Clostridium sordellii infection Title Other Names:. Clostridium sordellii toxic shock syndrome; C. sordellii infection ...
TcsL is the main C. sordellii toxin as most of toxigenic C. sordellii strains only synthesize this toxin. Intestinal ... The absence or moderate local inflammatory response allows C. sordellii spreading in deep tissues, production of toxin which is ... sordellii lethal toxin (TcsL) and hemorrhagic toxin (TcsH)) which belong to the large clostridial glucosylating toxin (LCGT) ... Clostridium difficile and Clostridium sordellii produce related potent toxins (C. difficile toxin A (TcdA) and toxin B (TcdB), ...
Clostridium sordellii (Hall and Scott) Prevot (ATCC® 9714™) ATCC® Number: 9714™ Strain Designations: 211 [NCIB 10717] ... Clostridium perfringens (Veillon and Zuber) Hauduroy et al. (ATCC® 13124™) ATCC® Number: 13124™ Strain Designations: NCTC 8237 ...
Clostridium sordellii (Hall and Scott) Prevot (ATCC® 9714™) ATCC® Number: 9714™ Strain Designations: 211 [NCIB 10717] ... Clostridium perfringens (Veillon and Zuber) Hauduroy et al. (ATCC® 13124™) ATCC® Number: 13124™ Strain Designations: NCTC 8237 ... Clostridium septicum (Mace) Ford (ATCC® 12464™) ATCC® Number: 12464™ Strain Designations: Pasteur III (NCTC 547) ...
1-acetyl-β-carboline; Clostridium difficile; Clostridium scindens; Clostridium sordellii; cyclic dipeptides; dysbiosis; gut ... A) PYF medium control; B) C. difficile grown in 50% C. sordellii spent culture medium; C) C. diffiicle incubated in 100% C. ... The purification protocols for antibacterial compounds secreted by C. sordellii and C. scindens are described in . The LC-ESI/ ... Clostridium scindens biotransforms primary bile acids into secondary bile acids, and is correlated with inhibition of ...
The woman had died from a serious infection caused by the abortion pill: Clostridium sordellii. Her death should have placed ...
  • Severe toxic shock syndrome among previously healthy persons has been described in a small number of C. sordellii cases, most often associated with gynecologic infections in women and infection of the umbilical stump in newborns. (cdc.gov)
  • Women are at highest risk of infection from C. sordellii following the end of pregnancy, whether that pregnancy ended in a live birth, induced abortion (medical or surgical), or spontaneous abortion (miscarriage). (cdc.gov)
  • The rate of vaginal colonization (when bacteria are present, but not causing an infection) with Clostridium species in the period after abortion has been reported to be as high as 29%, whereas these bacteria have been isolated in the vaginal secretions of 5%-10% of non-pregnant women. (cdc.gov)
  • Symptoms of a C. sordellii infection include nausea, vomiting, diarrhea, and sometimes abdominal pain without fever. (cdc.gov)
  • We describe an unusual and protracted course of disease in 6 captive brown pelicans (Pelecanus occidentalis), which was believed to result from toxicosis by toxovar A produced by a mixed infection with Clostridium sordellii and Clostridium perfringens. (thefreedictionary.com)
  • A healthy 4-year-old boy sustained a closed fracture of the arm and died of Clostridium sordellii infection 4 days later. (thefreedictionary.com)
  • Since 2000, five women North America who had medically induced abortions died from toxic shock caused by a Clostridium sordellii infection. (thefreedictionary.com)
  • Numerous case studies suggest that the incubation of C. sordellii after infection is 1 to 5 days [5][6] . (kenyon.edu)
  • We report 2 fatal cases, one of which was associated with minor trauma, and the other of which was associated with normal childbirth, and we summarize the clinical features of 43 additional cases of reported C. sordellii infection. (nih.gov)
  • Other cases of C. sordellii infection (in 19 patients [43%]) occurred after trauma or surgery, mostly in healthy persons, and 53% these patients died. (nih.gov)
  • Although the incidence of C. sordellii infection is low, it is fatal in most cases. (asm.org)
  • A major virulence factor in Clostridium sordellii -mediated infection is the toxin TcsL, which is encoded within a region of the genome called the pathogenicity locus (PaLoc). (asm.org)
  • Human infections with clostridia can result from endogenous or exogenous infection ( 5 ). (antimicrobe.org)
  • When intraperitoneally injected into Swiss mice, Clostridium sordellii lethal toxin reproduces the fatal toxic shock syndrome observed in humans and animals after natural infection. (pasteur.fr)
  • ClinicalTrials.gov lists trials that are related to Clostridium sordellii infection. (cdc.gov)
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Clostridium sordellii infection. (cdc.gov)
  • The infection originates in a wound contaminated with bacteria of the genus CLOSTRIDIUM. (fpnotebook.com)
  • Clostridium sordellii (now Paeniclostridium) can cause a fatal infection in exceptionally rare cases after medical abortions. (wikipedia.org)
  • Clostridium difficile (C. difficile) is one of the leading pathogens causing hospital-acquired infection in the United States. (k-state.edu)
  • Clostridium sordellii (or C. sordellii) normally exists in the vagina and does not cause infection. (vidanthealth.com)
  • A fifth case was linked to a similar bacterial infection with Clostridium perfringens. (c-span.org)
  • Gas gangrene and clostridial myonecrosis are interchangeable terms used to describe an infection of muscle tissue by toxin-producing clostridia. (medscape.com)
  • The global prevalence of severe Clostridium difficile infection highlights the profound clinical significance of clostridial glucosylating toxins. (semanticscholar.org)
  • Ceragenin CSA13 Reduces Clostridium difficile Infection in Mice by Modulating the Intestinal Microbiome and Metabolites. (semanticscholar.org)
  • Clostridial Myonecrosis (Gas Gangrene): A rare but extremely fatal disease that results from the infection of muscle tissue by exotoxin producing Clostridium bacteria Footnote 5 . (canada.ca)
  • These women died from sepsis (serious infection involving the bloodstream) and seven women were found to involve infection with bacteria known as Clostridium sordellii and one case involved infection with Clostridium perfringens. (lifenews.com)
  • Recent advances in the understanding of antibiotic resistance in Clostridium difficile infection. (asmscience.org)
  • C. perfringens or C. sordellii endometritis usually follows within 1 week or so of childbirth or abortion, although simple obstetric or gynecological procedures, such as amniocentesis or cervical excisions, may precede infection. (oncologynurseadvisor.com)
  • The clinical course is described of a patient who attended an A&E department with septicaemia who was found at postmortem examination to have been infected with Clostridium novyi type A. Doctors working in A&E departments should be aware of the existence of this infection and be vigilant when treating injecting drug users with localised infection. (bmj.com)
  • Misuse of injected drugs has been reported to be a risk factor for infection with Clostridium species including C tetani , 1 C botulinum 2 and C perfringens . (bmj.com)
  • There are several clinical features which are unique to C. sordellii: marked leukocytosis (leukaemoid reaction), refractory hypotension, severe tachycardia, haemoconcentration, persistent apyrexia and profound capillary leak syndrome (see entry for Clostridium novyi alpha-toxin for details of mechanism). (wikipedia.org)
  • Clostridium sordellii lethal toxin (TcsL) is a powerful virulence factor responsible for severe toxic shock in man and animals. (mdpi.com)
  • Lethal Toxin from Clostridium sordellii (TcsL), which is casually involved in the toxic shock syndrome and in gas gangrene, enters its target cells by receptor-mediated endocytosis. (mdpi.com)
  • The cst locus is present on all pCS1 subtypes, and homologous loci were identified on toxin-encoding plasmids from Clostridium perfringens and Clostridium botulinum and also carried within genomes of Clostridium difficile isolates, indicating that it is a widespread clostridial conjugation locus. (asm.org)
  • While the pathogenesis of C. sordellii infections is not well understood, it is known that the toxin TcsL is an important virulence factor. (asm.org)
  • Purification and characterization of Clostridium sordellii lethal toxin and cross-reactivity with Clostridium difficile cytotoxin. (asm.org)
  • Lethal toxin (LT) was purified from Clostridium sordellii IP82 by DEAE-Trisacryl, Ultrogel AcA3-4 gel filtration, and hydroxyapatite column chromatography. (asm.org)
  • A specific antiserum against LT neutralized the biological activities of LT and also cytotoxic activity and lethal activity of Clostridium difficile toxin B but not of C. difficile toxin A. However, this serum did not recognize antigen from C. difficile culture supernatant by immunoblotting. (asm.org)
  • and the demonstration of production of lecithinase (or alpha toxin by C. perfringens ) and lipase (by Clostridium sporogenes , Clostridium novyi and Clostridium botulinum ( 14 ). (antimicrobe.org)
  • Isolation of Clostridia from wound, pus, blood or faeces, along with toxin and serological assays aid in the diagnosis of clostridial infections. (antimicrobe.org)
  • The lethal toxin (LT) from Clostridium sordellii, which belongs to the family of large clostridial cytotoxins, acts as a monoglucosyltransferase for the Rho subfamily GTPase Rac and also modifies Ras. (uni-regensburg.de)
  • The lethal toxin of Clostridium sordellii (TcsL) evokes severe, mostly fatal disease patterns like toxic shock syndrome in humans and animals. (usda.gov)
  • Clostridium difficile and Clostridium sordellii produce related potent toxins (C. difficile toxin A (TcdA) and toxin B (TcdB), C. sordellii lethal toxin (TcsL) and hemorrhagic toxin (TcsH)) which belong to the large clostridial glucosylating toxin (LCGT) family. (archives-ouvertes.fr)
  • TcsL is the main C. sordellii toxin as most of toxigenic C. sordellii strains only synthesize this toxin. (archives-ouvertes.fr)
  • The absence or moderate local inflammatory response allows C. sordellii spreading in deep tissues, production of toxin which is released in the general circulation and causes a toxic shock syndrome. (archives-ouvertes.fr)
  • Cell-penetrating peptides derived from Clostridium difficile TcdB2 and a related large clostridial toxin. (nih.gov)
  • Intrinsic Toxin-Derived Peptides Destabilize and Inactivate Clostridium difficile TcdB. (nih.gov)
  • Coordination between T helper cells, iNKT cells, and their follicular helper subsets in the humoral immune response against Clostridium difficile toxin B. (nih.gov)
  • Memory B Cells Encode Neutralizing Antibody Specific for Toxin B from the Clostridium difficile Strains VPI 10463 and NAP1/BI/027 but with Superior Neutralization of VPI 10463 Toxin B. (nih.gov)
  • The main species responsible for disease in humans are: Clostridium botulinum can produce botulinum toxin in food or wounds and can cause botulism. (wikipedia.org)
  • Specific inhibition of geranylgeranyltransferase-I and Rac/Cdc42 by GGTI-286 and Clostridium sordellii lethal toxin, respectively, enhanced TM expression, whereas inactivation of Rho by Clostridium botulinum C3 exoenzyme was ineffective. (ahajournals.org)
  • Clostridium difficile toxin-induced inflammation and intestinal injury are mediated by the inflammasome. (semanticscholar.org)
  • The source of the bacteria has not been determined but it has been documented that about 0.5% to 10% of healthy women are lengthened vaginal carriage of C. sordellii. (wikipedia.org)
  • Any of various rod-shaped, spore-forming, chiefly anaerobic bacteria of the genus Clostridium, such as certain nitrogen-fixing species found in soil and those causing botulism and tetanus. (thefreedictionary.com)
  • Some microbiologists hypothesize that the bacteria can travel from person to person and from contaminated surfaces to person in a similar manner to other Clostridium species, although there has yet to be a study confirming this to be true for C. sordellii . (kenyon.edu)
  • Bile Acid 7α-Dehydroxylating Gut Bacteria Secrete Antibiotics that Inhibit Clostridium difficile: Role of Secondary Bile Acids. (nih.gov)
  • The bile acid 7α-dehydroxylating gut bacteria, C. scindens and C. sordellii, were found to secrete the tryptophan-derived antibiotics, 1-acetyl-β-carboline and turbomycin A, respectively. (nih.gov)
  • C. sordellii is a rare bacteria, most often causing infections in patients with underlying medical conditions. (beckershospitalreview.com)
  • Clostridium is a genus of Gram-positive bacteria. (wikipedia.org)
  • Clostridium contains around 250 species that include common free-living bacteria, as well as important pathogens. (wikipedia.org)
  • In November it updated its alert to say that all four women were infected with the same Clostridium sordellii bacteria. (chicagotribune.com)
  • Here we report the identification of 1104 LCT-T homologs, with 769 proteins from bacteria outside of clostridia. (nature.com)
  • Clostridium is a genus of gram-positive, spore-forming bacteria belonging to the family Clostridiaceae. (canada.ca)
  • Clostridium is a genus of Gram-positive bacteria, that are obligate anaerobes capable of producing endospores. (novusbio.com)
  • Clostridium includes common free-living bacteria as well as important pathogens. (novusbio.com)
  • Fatal infections with C. sordellii and C. perfringens have occurred after medical abortion. (cdc.gov)
  • Illicit drug users are especially susceptible to C. sordellii infections and certain drugs have shown more apt to transmit the bacterium [4] . (kenyon.edu)
  • Along with IDU, C. sordelli infections have been associated with medically induced abortions, minor traumas and surgeries, spontaneous abortions and normal childbirth-the tools used in these operations are not found to carry C. sordellii on their surfaces [1] . (kenyon.edu)
  • The populations most susceptible to Clostridium sordellii infections are women nearing the end of pregnancy, whether that concludes in live birth, medical abortion, or miscarriage [2] . (kenyon.edu)
  • Clostridium sordellii infections pose difficult clinical challenges and are usually fatal. (nih.gov)
  • Ten (22%) of the C. sordellii infections occurred in injection drug users, and 50% of these patients died. (nih.gov)
  • Since spore germination is believed to be the first step in the establishment of Bacilli and Clostridia infections, we analyzed the requirements for C. sordellii spore germination in vitro . (asm.org)
  • Severe capillary leakage, toxic shock syndrome, and an extreme leukemoid reaction (LR), are hallmark features of C. sordellii infections and contribute to its high mortality rate. (rsc.org)
  • These findings have the potential to help advance new therapeutics and diagnostics against deadly C. sordellii infections. (rsc.org)
  • IMPORTANCE C. sordellii is a bacterial pathogen that causes severe infections in humans and animals, with high mortality rates. (asm.org)
  • Clostridia are also often isolated from polymicrobial intraabdominal, biliary, pleuropulmonary, central nervous system, genitourinary and skin and soft tissue infections ( 5 ). (antimicrobe.org)
  • The role of clostridia in the pathogenesis of polmicrobial infections is unclear ( 28 , 29 ). (antimicrobe.org)
  • Intravenous drug use can also cause C. sordellii infections. (massgeneral.org)
  • Fatal Clostridium sordellii infections after medical abortions. (ipas.org)
  • Clostridium sordellii infections. (vidanthealth.com)
  • Of the U.S. cases, four resulted from infections with Clostridium sordellii, a rare bacterium. (c-span.org)
  • Clostridium perfringens, which produces a huge array of invasins and exotoxins, causes wound and surgical infections that lead to gas gangrene, in addition to severe uterine infections. (novusbio.com)
  • The clostridia implicated in these (presumably) hematogenous infections include C. septicum , C. tertium, C. perfringens , and C. novyi . (oncologynurseadvisor.com)
  • Severe infections caused by Clostridium species have been described in the medical literature for centuries-largely because of their fulminant nature, distinctive clinical presentations, and complex management issues. (asmscience.org)
  • however, it reveals that toxins produced by C. sordellii are more lethal than in any other Clostridium spp. (kenyon.edu)
  • Clostridium sordellii is a lethal pathogen for both animals and humans. (rsc.org)
  • Clostridium novyi produces lethal toxins. (novusbio.com)
  • C. septicum can cause spontaneous, non-traumatic gas gangrene, and C. sordellii can induce gas gangrene of the uterus, as a consequence of spontaneous abortion, normal vaginal delivery and traumatic injury. (antimicrobe.org)
  • For use in healthy cattle and sheep as an aid in the prevention of diseases caused by C. chauvoei (blackleg) , C. septicum (malignant edema), C. novyi (black disease), C. sordellii (gas-gangrene), and C. perfringens Types B, C, and D (enterotoxemia). (drugs.com)
  • Other common clostridial species that cause gas gangrene include Clostridium bifermentans, Clostridium septicum, Clostridium sporogenes, Clostridium novyi, Clostridium fallax, Clostridium histolyticum, and Clostridium tertium . (medscape.com)
  • Microbiology) any anaerobic typically rod-shaped bacterium of the genus Clostridium , occurring mainly in soil, but also in the intestines of humans and animals: family Bacillaceae . (thefreedictionary.com)
  • Clostridium sordelli is a gram positive, spore-forming, anaerobic rod [1] . (kenyon.edu)
  • Clostridium sordellii is a spore-forming, obligately anaerobic, Gram-positive bacterium that can cause toxic shock syndrome after gynecological procedures. (asm.org)
  • Organisms of the genus Clostridium are important members of the humans' anaerobic gastrointestinal and cervical-vaginal flora. (antimicrobe.org)
  • Gas gangrene is caused by an anaerobic, gram-positive, spore-forming bacillus of the genus Clostridium . (medscape.com)
  • A recent clinical series on gas gangrene demonstrated a predominance (83.3%) of aerobic gram-negative bacilli in wound cultures compared with anaerobic gram-positive bacilli, with Clostridium species accounting for 4.5% of the isolates. (medscape.com)
  • In response to recent reports of unexplained deaths in injecting drug users, the autopsy specimen from the left thigh lesion was recultured and yielded an anaerobe that was identified by the Anaerobic Reference Laboratory in Cardiff as Clostridium novyi type A. (bmj.com)
  • Clostridium sordellii [klaw-strĭ-dee-um sore-dell-ee-i] (also called C. sordellii ) is a rare bacterium that causes pneumonia, endocarditis, arthritis, peritonitis, and myonecrosis. (cdc.gov)
  • So far, all documented post-partum females who contracted C. sordellii septicaemia have died, and all but one woman who contracted the bacterium post-abortion have died[citation needed]. (wikipedia.org)
  • The pathogen that killed several abortion patients was Clostridium sordellii , a common bacterium that can prove deadly when it gets into the bloodstream. (thefreedictionary.com)
  • Three of the five deaths were caused by a rare bacterium Clostridium sordellii. (bio-medicine.org)
  • Three of the case s involved a rare bacterium known as Clostridium sordellii, Danco's statement said. (bio-medicine.org)
  • Clostridium novyi type A is a bacterium that has recently been associated with a number of fatalities among drug injecting addicts. (bmj.com)
  • Clostridium and Bacillus are both in the phylum Firmicutes, but they are in different classes, orders, and families. (wikipedia.org)
  • Clostridia are a class of Firmicutes, including Clostridium and other similar genera. (novusbio.com)
  • Other similar Clostridium species are spread from person to person and sometimes contaminated surfaces are involved in this transmission. (cdc.gov)
  • There are no known zoonotic Clostridium species, meaning they cannot transmit directly from animal to human [5] . (kenyon.edu)
  • In general, Clostridium species are transmitted through contaminated wound sites and discontinuities in the gastrointestinal tract [5] . (kenyon.edu)
  • In Clostridium species the average incubation is 6 hours to 3 days [6] . (kenyon.edu)
  • Unlike the case for Bacilli species, d -alanine had no effect on C. sordellii spore germination. (asm.org)
  • Clostridium perfringens is the most important of the species and accounts for 20-40% of all isolates. (antimicrobe.org)
  • Any bacterial organism that can be assigned to the species Clostridium perfringens. (fpnotebook.com)
  • Clostridium species inhabit soils and the intestinal tract of animals, including humans. (wikipedia.org)
  • The issue was originally illustrated in full detail by a rRNA phylogeny from Collins 1994, which split the traditional genus (now corresponding to a large slice of Clostridia) into twenty clusters, with cluster I containing the type species and its close relatives. (wikipedia.org)
  • Clostridia are obligate anaerobes, but some species are relatively aerotolerant. (medscape.com)
  • There are close to 200 species of Clostridium, with only a few species being pathogenic to humans. (canada.ca)
  • Clostridium tetani causes tetanus. (wikipedia.org)
  • Clostridium welchii and Clostridium tetani respond to sulfonamides. (wikipedia.org)
  • Clostridium sordellii (and not Clostridium tetani) was isolated. (mn.us)
  • C. sordellii is ubiquitous in the environment, and C. tetani is rarely isolated from tetanus cases. (mn.us)
  • Tetanus (Clostridium tetani) 1996 case definition. (mdedge.com)
  • That vaccinates the calf against the toxins produced by Clostridium tetani. (cattletoday.com)
  • Here, we have shown the ability of a plasmid carrying the tcsL gene to undergo conjugative transfer between distantly related strains of C. sordellii , which has far-reaching implications for the ability of C. sordellii to acquire the capacity to cause disease. (asm.org)
  • For more information see the Clostridium sordellii Toxic Shock Syndrome After Medical Abortion with Mifepristone and Intravaginal Misoprostol - United States and Canada, 2001-2005 . (cdc.gov)
  • Undiagnosed cases of fatal clostridium-associated toxic shock in californian women of childbearing age. (cdc.gov)
  • Toxic shock associated with clostridium sordellii and clostridium perfringens after medical and spontaneous abortion. (cdc.gov)
  • Endometritis and toxic shock syndrome associated with Clostridium sordellii have previously been reported after childbirth and, in one case, after medical abortion. (nih.gov)
  • We describe four deaths due to endometritis and toxic shock syndrome associated with C. sordellii that occurred within one week after medically induced abortions. (nih.gov)
  • C. sordellii is one of the causes of toxic shock syndrome associated with gynaecological procedures, childbirth, and abortion Footnote 12 . (canada.ca)
  • The relevance of this information suggests that C. sordellii fatal toxic shock after medical abortion must be recognized as a global concern," he told LifeNews. (lifenews.com)
  • Clostridium perfringens is the most common clinical isolate of the genus. (antimicrobe.org)
  • Clostridium can be distinguished from Desulfotomaculum on the basis of the nutrients each genus uses (the latter requires sulfur). (wikipedia.org)
  • Nine cases of fatal Clostridium sepsis occurred in North America following mifepristone and misoprostol medical abortion before 13 weeks gestation (Cohen et al. (ipas.org)
  • 2004) A Fatal Case of Clostridium sordellii Septic Shock Syndrome Associated With Medical Abortion. (womenonwaves.org)
  • Our data showed that C. sordellii spores require three structurally different amino acids and bicarbonate for maximum germination. (asm.org)
  • C. sordellii spores germinated only in a narrow pH range between 5.7 and 6.5. (asm.org)
  • Heat resistance of Clostridium sordellii spores. (doktori.hu)
  • In terms of management, there is no hard and fast rule, as with most bacterial pathogens, but past data reveals C. sordellii susceptibility to beta-lactams, clindamycin, tetracycline and chloramphenicol but resistant to aminoglycosides and sulphonamides. (wikipedia.org)
  • 39:1483-8 Nakamura S, Yamakawa K, Nishida S. Antibacterial susceptibility of Clostridium sordellii strains. (wikipedia.org)
  • Clostridium sordelli is a virulent strain of Clostridium bifermentans that causes pneumonia, endocarditis, arthritis, peritonitits, myonecrosis, bacteremia and sepsis in humans in more serious strains of the disease [1][2] . (kenyon.edu)
  • Clostridium chauvoei is the causative agent of blackleg in cattle, it is a very virulent pathogen of cattle that causes fever, depression, lameness, and a high level of mortality. (novusbio.com)
  • C. sordellii bacteremia and sepsis occur rarely. (cdc.gov)
  • Most cases of sepsis from C. sordellii occur in patients with underlying conditions. (cdc.gov)
  • Clostridium sordellii ) and sepsis can present without fever, bacteremia or significant findings on pelvic examination. (earlyoptionpill.com)
  • Using a derivative of the pCS1-1 plasmid from strain ATCC 9714 which had been marked with the ermB erythromycin resistance gene, conjugative transfer into a recipient C. sordellii isolate, R28058, was demonstrated. (asm.org)
  • OS Paeniclostridium sordellii ATCC 9714. (genome.jp)
  • Molecular and microbiological characterization of Clostridium difficile isolates from single, relapse, and reinfection cases. (asmscience.org)
  • CDC experts in microbiology, epidemiology, and perinatology (pregnancy-related complications) are working together with state and local health agencies and the FDA in the investigation of recent deaths associated with C. sordellii . (cdc.gov)
  • Researchers continue to study what percentage of women carries vaginal or rectal C. sordellii and C. perfringens before and after abortion, as well as during pregnancy. (cdc.gov)
  • C. sordellii mainly affects women and is often linked to end of pregnancy, whether the pregnancy resulted in childbirth, abortion or spontaneous abortion. (beckershospitalreview.com)
  • The Portuguese girl in question died after an abortion with the RU 486 abortion drug caused Clostridium sordellii septic shock. (lifenews.com)
  • This may be the first reported global case that needs to be further investigated as part of the ongoing review of C. sordellii medical abortion deaths that includes my daughter, Holly Patterson and others in the United States and Canada," he told LifeNews.com. (lifenews.com)
  • Simple radiographs are often associated with clostridium sordellii after medical abortion. (pacoimabeautiful.org)
  • Clostridium perfringens causes a wide range of symptoms, from food poisoning to cellulitis, fasciitis, necrotic enteritis and gas gangrene. (wikipedia.org)
  • In 1927 the organism was renamed Bacillus sordellii and two years later it became classified as Clostridium sordellii , as it is almost indistinguishable from Clostridium oedematoides [1] . (kenyon.edu)
  • This organism, originally known as Bacillus aerogenes capsulatus, was later renamed Bacillus perfringens, and then Clostridium welchii . (medscape.com)
  • The organism is now named Clostridium perfringens . (medscape.com)
  • Microbiological analysis of a swab of the left thigh yielded an organism, provisionally identified as Clostridium sordellii . (bmj.com)
  • TcdB from hypervirulent Clostridium difficile exhibits increased efficiency of autoprocessing. (semanticscholar.org)
  • Clostridium difficile , the main cause of diarrhea in hospitalized patients, produces toxins A (TcdA) and B (TcdB), which affect intestinal epithelial cell survival, proliferation, and migration and induce an intense inflammatory response. (asm.org)
  • Follow-up in vitro and in vivo work is under way to further characterize Mcs1 enzymatic kinetics and its role in C. sordellii pathogenesis. (rsc.org)
  • Bacillus and Clostridium are often described as Gram-variable, because they show an increasing number of gram-negative cells as the culture ages. (wikipedia.org)
  • The Schaeffer-Fulton stain (0.5% malachite green in water) can be used to distinguish endospores of Bacillus and Clostridium from other microorganisms. (wikipedia.org)
  • Current antimicrobial susceptibilities among the clostridia are also presented, as are the evaluation, interpretation, and reporting of clinical microbiology laboratory results. (asmscience.org)
  • Tests performed by the Food and Drug Administration (FDA) have not detected contamination with C. sordellii of either of the medications used in medical abortions. (cdc.gov)
  • It was concluded that antibodies prepared from C. sordellii LT that neutralized C. difficile cytotoxic activity recognized a low number of epitopes or tertiary structures of C. difficile cytotoxin. (asm.org)
  • Cultures for Clostridium difficile in stools containing a cytotoxin neutralized by Clostridium sordellii antitoxin. (asm.org)
  • Pathophysiology of mifepristone-induced septic shock due to Clostridium sordellii. (wikipedia.org)
  • Clostridium and Desulfotomaculum are both in the class Clostridia and order Clostridiales, and they both produce bottle-shaped endospores, but they are in different families. (wikipedia.org)
  • C. sordellii isolates carry the PaLoc on the pCS1 family of plasmids, of which there are four characterized members. (asm.org)
  • The significance of clostridia in polymicrobial isolates is unknown. (antimicrobe.org)
  • Clostridium perfringens (Veillon and Zuber) Hauduroy et al. (atcc.org)
  • Clostridia are ubiquitous and are found in the soil, marine sediment, decaying vegetation and intestinal tract of humans, other vertebrate and insects. (antimicrobe.org)
  • Clostridia have been isolated from the mucous membranes of humans, including the GI tract and the female genital tract. (medscape.com)
  • For the most part, clostridia are soil organisms, but they also colonize or contaminate the enteric tracts of animals and humans. (oncologynurseadvisor.com)
  • Clostridium difficile ClpP Homologues are Capable of Uncoupled Activity and Exhibit Different Levels of Susceptibility to Acyldepsipeptide Modulation. (nih.gov)
  • Pathogen Safety Data Sheets: Infectious Substances - Clostridium spp. (canada.ca)
  • Three outbreaks of necrotic enteritis-like disease associated with Clostridium sordellii were diagnosed in commercial broiler chicken flocks with 18,000 to 31,000 birds between 18 and 26 days old. (elsevier.com)
  • A retrospective study of commercial broiler chicken and Turkey submissions to the California Animal Health and Food Safety Laboratory System revealed that C. sordellii had been isolated from intestinal lesions in outbreaks of necrotic enteritis-like disease in 8 of 39 cases, 5 times together with Clostridium perfringens and 3 times alone. (elsevier.com)
  • Because antimicrobial susceptibilities are relatively similar among these clostridia, this should not influence empiric antibiotic choices. (oncologynurseadvisor.com)