Clostridium histolyticum
Clostridium
Dupuytren Contracture
Microbial Collagenase
Clostridium difficile
Collagen
Clostridium botulinum
A novel galactooligosaccharide mixture increases the bifidobacterial population numbers in a continuous in vitro fermentation system and in the proximal colonic contents of pigs in vivo. (1/23)
Prebiotics are nondigestible food ingredients that encourage proliferation of selected groups of the colonic microflora, thereby altering the composition toward a more beneficial community. In the present study, the prebiotic potential of a novel galactooligosaccharide (GOS) mixture, produced by the activity of galactosyltransferases from Bifidobacterium bifidum 41171 on lactose, was assessed in vitro and in a parallel continuous randomized pig trial. In situ fluorescent hybridization with 16S rRNA-targeted probes was used to investigate changes in total bacteria, bifidobacteria, lactobacilli, bacteroides, and Clostridium histolyticum group in response to supplementing the novel GOS mixture. In a 3-stage continuous culture system, the bifidobacterial numbers for the first 2 vessels, which represented the proximal and traverse colon, increased (P < 0.05) after the addition of the oligosaccharide mixture. In addition, the oligosaccharide mixture strongly inhibited the attachment of enterohepatic Escherichia coli (P < 0.01) and Salmonella enterica serotype Typhimurium (P < 0.01) to HT29 cells. Addition of the novel mixture at 4% (wt:wt) to a commercial diet increased the density of bifidobacteria (P < 0.001) and the acetate concentration (P < 0.001), and decreased the pH (P < 0.001) compared with the control diet and the control diet supplemented with inulin, suggesting a great prebiotic potential for the novel oligosaccharide mixture. (+info)Differences between the gut microflora of children with autistic spectrum disorders and that of healthy children. (2/23)
Children with autistic spectrum disorders (ASDs) tend to suffer from severe gastrointestinal problems. Such symptoms may be due to a disruption of the indigenous gut flora promoting the overgrowth of potentially pathogenic micro-organisms. The faecal flora of patients with ASDs was studied and compared with those of two control groups (healthy siblings and unrelated healthy children). Faecal bacterial populations were assessed through the use of a culture-independent technique, fluorescence in situ hybridization, using oligonucleotide probes targeting predominant components of the gut flora. The faecal flora of ASD patients contained a higher incidence of the Clostridium histolyticum group (Clostridium clusters I and II) of bacteria than that of healthy children. However, the non-autistic sibling group had an intermediate level of the C. histolyticum group, which was not significantly different from either of the other subject groups. Members of the C. histolyticum group are recognized toxin-producers and may contribute towards gut dysfunction, with their metabolic products also exerting systemic effects. Strategies to reduce clostridial population levels harboured by ASD patients or to improve their gut microflora profile through dietary modulation may help to alleviate gut disorders common in such patients. (+info)Crystallization and preliminary X-ray characterization of the catalytic domain of collagenase G from Clostridium histolyticum. (3/23)
(+info)Unidirectional binding of clostridial collagenase to triple helical substrates. (4/23)
(+info)A universal strategy for high-yield production of soluble and functional clostridial collagenases in E. coli. (5/23)
(+info)Injectable collagenase clostridium histolyticum for Dupuytren's contracture. (6/23)
(+info)Inhibitive effects of alkyl gallates on hyaluronidase and collagenase. (7/23)
A series of the gallate esters of n-alkanols (C(1)-C(12)) was examined to determine their inhibitory activities against hyaluronidase and collagenase. Hexyl, heptyl, octyl, nonyl, and decyl gallates inhibited both hyaluronidase and collagenase, and the most potent inhibitor was octyl gallate against both enzymes. Octyl 3,5-dihydroxybenzoate showed inhibitory effects on hyaluronidase, whereas collagenase was inhibited by octyl 3,4-dihydroxybenzoate. (+info)Tissue dissociation enzyme neutral protease assessment. (8/23)
(+info)The cause of Dupuytren contracture is not fully understood, but it is believed to be related to genetic factors and may be more common in people of Northern European ancestry. Other risk factors include a family history of the condition, alcoholism, diabetes, and liver or kidney disease.
The symptoms of Dupuytren contracture can progress slowly over time, with the fingers gradually becoming more bent and rigid. In some cases, the contracture can become severe enough to interfere with hand function and daily activities. Treatment options for Dupuytren contracture include physical therapy, splints, and surgery.
Surgery is often recommended for people with severe contractures or those who have significant difficulty with hand function. The goal of surgery is to release the contracted tissue and restore normal hand movement. However, surgery is not always successful, and recurrence of the contracture is common.
In addition to surgery, other treatment options for Dupuytren contracture include:
* Physical therapy to improve hand function and range of motion
* Splints to help straighten the fingers
* Injections of enzymes or other medications to dissolve the contracted tissue
* Radiofrequency ablation to heat and shrink the contractured tissue
It is important to note that Dupuytren contracture is a chronic condition, meaning it cannot be cured and will require ongoing treatment and monitoring. With proper treatment and management, however, many people with Dupuytren contracture are able to maintain functional use of their hands and improve their quality of life.
Some common types of Clostridium infections include:
* Clostridium difficile (C. diff) infection: This is a common type of diarrheal disease that can occur after taking antibiotics, especially in people who are hospitalized or living in long-term care facilities.
* Gas gangrene: This is a severe and potentially life-threatening infection that occurs when Clostridium bacteria infect damaged tissue, causing gas to build up in the affected area.
* Tetanus: This is a serious neurological infection caused by the bacterium Clostridium tetani, which can enter the body through open wounds or puncture wounds.
* Botulism: This is a potentially fatal illness caused by the bacterium Clostridium botulinum, which can be contracted through contaminated food or wounds.
Clostridium infections can cause a range of symptoms, including diarrhea, fever, abdominal pain, and swelling or redness in the affected area. Treatment depends on the type of infection and may include antibiotics, surgery, or supportive care to manage symptoms.
Prevention measures for Clostridium infections include proper hand hygiene, avoiding close contact with people who are sick, and practicing safe food handling practices to prevent the spread of botulism and other clostridial infections. Vaccines are also available for some types of clostridial infections, such as tetanus and botulism.
In summary, Clostridium infections are a diverse group of bacterial infections that can cause a range of illnesses, from mild to severe and life-threatening. Proper prevention and treatment measures are essential to avoid the potential complications of these infections.
Collagenase clostridium histolyticum
Hathewaya histolytica
Clostridial aminopeptidase
Clostripain
Clostridium
Dupuytren's contracture
Microbial collagenase
Collagenase
Debridement
List of Clostridium species
Ines Mandl
Peyronie's disease
Controversies in autism
Culley C. Carson III
Plantar fibromatosis
Clostridium novyi-NT
DEPT (medicine)
List of drugs: Cm-Co
Renaissance School of Medicine at Stony Brook University
Bioprospecting
ATC code M09
List of MeSH codes (B03)
Collagenase Clostridium histolyticum Injection: MedlinePlus Drug Information
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Collagenase Clostridium16
- Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with collagenase Clostridium histolyticum (Xiaflex) and each time you receive the medication. (medlineplus.gov)
- Talk to your doctor about the risks of receiving collagenase Clostridium histolyticum injection (Xiaflex). (medlineplus.gov)
- Collagenase Clostridium histolyticum injection (Xiaflex) is used to treat Dupuytren's contracture (a painless thickening and tightening of tissue [cord] beneath the skin in the palm of the hand, which may make it difficult to straighten one or more fingers) when a cord of tissue can be felt upon examination. (medlineplus.gov)
- Collagenase Clostridium histolyticum injection (Xiaflex) is also used to treat Peyronie's disease (a thickening of tissue [plaque] inside the penis that causes the penis to curve). (medlineplus.gov)
- Collagenase Clostridium histolyticum injection (QWO) is also used to treat cellulite (fat deposit beneath the skin) in the buttocks of adult women. (medlineplus.gov)
- Collagenase Clostridium histolyticum injection is in a class of medications called enzymes. (medlineplus.gov)
- Collagenase Clostridium histolyticum injection comes as a powder to be mixed with a liquid and injected by a doctor. (medlineplus.gov)
- If you are receiving collagenase Clostridium histolyticum injection (Xiaflex) to treat Dupuytren's contracture, your doctor will inject the medicine into a cord just under the skin in the affected hand. (medlineplus.gov)
- If you are receiving collagenase Clostridium histolyticum injection (Xiaflex) to treat Peyronie's disease, your doctor will inject the medicine into the plaque that is causing your penis to curve. (medlineplus.gov)
- If you are receiving collagenase Clostridium histolyticum (QWO) to treat cellulite, your doctor will inject it subcutaneously (just under the skin) into the buttock(s). (medlineplus.gov)
- If you are receiving treatment for Peyronie's disease, your doctor will inject collagenase Clostridium histolyticum into your penis, followed by a second injection 1 to 3 days after the first injection. (medlineplus.gov)
- Intralesional collagenase clostridium histolyticum (marketed as Xiaflex ® ) may be helpful. (dermnetnz.org)
- Xiaflex (collagenase clostridium histolyticum) is the first drug to be approved in the US to treat a progressive hand disease known as Dupuytren's contracture. (battlingforhealth.com)
- Injections of Collagenase Clostridium histolyticum (CCh) can be an effective way to treat men with Peyronie's disease. (smsna.org)
- For men with Peyronie's disease, treatment with collagenase clostridium histolyticum (CCH) has become more popular over the years. (smsna.org)
- The only FDA-approved medication for Peyronie's disease is collagenase clostridium histolyticum (called by its brand-name, Xiaflex ). (houstonmenshealth.com)
Xiaflex2
- Serious injury to the penis, including penile fracture (corporal rupture), has been reported in patients receiving Clostridium histolyticum injection (Xiaflex) for treatment of Peyronie's disease. (medlineplus.gov)
- Xiaflex, made from the protein product of a species of the bacterium Clostridium, is the first non-surgical therapy for Dupuytren's contracture, a disease common in Caucasian men over 50. (battlingforhealth.com)
Collagenaseccollagenase clostridium histolyticum-aaes1
- Qwo (collagenaseccollagenase clostridium histolyticum-aaes) is the first and only FDA-approved injectable for moderate to severe cellulite in the buttocks of adult women. (happycliniccos.com)
Perfringens2
- Other anaerobes, including C . novyi , C . histolyticum , and C . perfringens , were isolated from injection site wounds of 3 patients. (cdc.gov)
- 005.0 Staphylococcal food poisoning Staphylococcal toxaemia specified as due to food 005.1 Botulism Food poisoning due to Clostridium botulinum 005.2 Food poisoning due to Clostridium perfringens [Cl. (cdc.gov)
Species2
- Type species of the genus CLOSTRIDIUM, a gram-positive bacteria in the family Clostridiaceae. (bvsalud.org)
- Clostridium glycyrrhizinilyticum is the correct name if this species is regarded as a separate species (i.e., if its nomenclatural type is not assigned to another species whose name is validly published, legitimate and not rejected and has priority) within a separate genus Clostridium . (dsmz.de)
Collagenase clostridium histolyticum-aaes2
- The Food and Drug Administration has approved collagenase clostridium histolyticum-aaes (Qwo, Endo International) for the treatment of moderate to severe cellulite in the buttocks of adult women. (medscape.com)
- Cite this: FDA Approves Collagenase Clostridium Histolyticum-aaes for Cellulite - Medscape - Jul 09, 2020. (medscape.com)
Novyi2
- Other anaerobes, including C . novyi , C . histolyticum , and C . perfringens , were isolated from injection site wounds of 3 patients. (cdc.gov)
- This was also found in a large international outbreak of C . novyi in IDUs ( 7 ) and a botulism outbreak in IDUs in California ( 6 ), and is consistent with the obligate anaerobe characteristic of Clostridium spp. (cdc.gov)
Cellulite2
- Collagenase Clostridium histolyticum injection (QWO) is also used to treat cellulite (fat deposit beneath the skin) in the buttocks of adult women. (medlineplus.gov)
- If you are receiving collagenase Clostridium histolyticum (QWO) to treat cellulite, your doctor will inject it subcutaneously (just under the skin) into the buttock(s). (medlineplus.gov)
Peyronie's1
- If you are receiving treatment for Peyronie's disease, your doctor will inject collagenase Clostridium histolyticum into your penis, followed by a second injection 1 to 3 days after the first injection. (medlineplus.gov)
Powder2
- Collagenase Clostridium histolyticum injection comes as a powder to be mixed with a liquid and injected by a doctor. (medlineplus.gov)
- Single-use glass vials containing 0.9 mg of collagenase clostridium histolyticum as a sterile, lyophilized powder for reconstitution. (nih.gov)
Treatment1
- 2. Injectable Clostridium histolyticum collagenase as a potential treatment for uterine fibroids. (nih.gov)