A species of anaerobic, gram-positive, rod-shaped bacteria in the family Clostridiaceae that produces proteins with characteristic neurotoxicity. It is the etiologic agent of BOTULISM in humans, wild fowl, HORSES; and CATTLE. Seven subtypes (sometimes called antigenic types, or strains) exist, each producing a different botulinum toxin (BOTULINUM TOXINS). The organism and its spores are widely distributed in nature.
Clostridium botulinum type B
Subtype of CLOSTRIDIUM BOTULINUM that produces botulinum toxin type B which is neurotoxic to humans and animals.
Toxic proteins produced from the species CLOSTRIDIUM BOTULINUM. The toxins are synthesized as a single peptide chain which is processed into a mature protein consisting of a heavy chain and light chain joined via a disulfide bond. The botulinum toxin light chain is a zinc-dependent protease which is released from the heavy chain upon ENDOCYTOSIS into PRESYNAPTIC NERVE ENDINGS. Once inside the cell the botulinum toxin light chain cleaves specific SNARE proteins which are essential for secretion of ACETYLCHOLINE by SYNAPTIC VESICLES. This inhibition of acetylcholine release results in muscular PARALYSIS.
A disease caused by potent protein NEUROTOXINS produced by CLOSTRIDIUM BOTULINUM which interfere with the presynaptic release of ACETYLCHOLINE at the NEUROMUSCULAR JUNCTION. Clinical features include abdominal pain, vomiting, acute PARALYSIS (including respiratory paralysis), blurred vision, and DIPLOPIA. Botulism may be classified into several subtypes (e.g., food-borne, infant, wound, and others). (From Adams et al., Principles of Neurology, 6th ed, p1208)
Clostridium botulinum type E
Subtype of CLOSTRIDIUM BOTULINUM that produces botulinum toxin type E which is neurotoxic to humans and animals.
Clostridium botulinum type A
Antiserum given therapeutically in BOTULISM.
Clostridium botulinum type F
Subtype of CLOSTRIDIUM BOTULINUM that produces botulinum toxin type F which is neurotoxic to humans and animals.
Clostridium botulinum type D
Subtype of CLOSTRIDIUM BOTULINUM that produces botulinum toxin type D which is neurotoxic to ANIMALS, especially CATTLE, but not humans.
Botulinum Toxins, Type A
A serotype of botulinum toxins that has specificity for cleavage of SYNAPTOSOMAL-ASSOCIATED PROTEIN 25.
Clostridium botulinum type C
Subtype of CLOSTRIDIUM BOTULINUM that produces botulinum toxin type C which is neurotoxic to ANIMALS, especially CATTLE, but not humans. It causes dissociation of ACTIN FILAMENTS.
Preparations of pathogenic organisms or their derivatives made nontoxic and intended for active immunologic prophylaxis. They include deactivated toxins. Anatoxin toxoids are distinct from anatoxins that are TROPANES found in CYANOBACTERIA.
Clostridium botulinum type G
Subtype of CLOSTRIDIUM BOTULINUM that produces botulinum toxin type G. Though it has been isolated from soil, no outbreaks involving this type have been recognized.
Lethal Dose 50
SNARE proteins where the central amino acid residue of the SNARE motif is an ARGININE. They are classified separately from the Q-SNARE PROTEINS where the central amino acid residue of the SNARE motif is a GLUTAMINE. This subfamily contains the vesicle associated membrane proteins (VAMPs) based on similarity to the prototype for the R-SNAREs, VAMP2 (synaptobrevin 2).
Infections with bacteria of the genus CLOSTRIDIUM.
Antisera from immunized animals that is purified and used as a passive immunizing agent against specific BACTERIAL TOXINS.
Heat and stain resistant, metabolically inactive bodies formed within the vegetative cells of bacteria of the genera Bacillus and Clostridium.
ADP Ribose Transferases
Enzymes that transfer the ADP-RIBOSE group of NAD or NADP to proteins or other small molecules. Transfer of ADP-ribose to water (i.e., hydrolysis) is catalyzed by the NADASES. The mono(ADP-ribose)transferases transfer a single ADP-ribose. POLY(ADP-RIBOSE) POLYMERASES transfer multiple units of ADP-ribose to protein targets, building POLY ADENOSINE DIPHOSPHATE RIBOSE in linear or branched chains.
Containers, packaging, and packaging materials for processed and raw foods and beverages. It includes packaging intended to be used for storage and also used for preparation of foods such as microwave food containers versus COOKING AND EATING UTENSILS. Packaging materials may be intended for food contact or designated non-contact, for example, shipping containers. FOOD LABELING is also available.
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN.
Drugs used for their actions on skeletal muscle. Included are agents that act directly on skeletal muscle, those that alter neuromuscular transmission (NEUROMUSCULAR BLOCKING AGENTS), and drugs that act centrally as skeletal muscle relaxants (MUSCLE RELAXANTS, CENTRAL). Drugs used in the treatment of movement disorders are ANTI-DYSKINESIA AGENTS.
A method of measuring the effects of a biologically active substance using an intermediate in vivo or in vitro tissue or cell model under controlled conditions. It includes virulence studies in animal fetuses in utero, mouse convulsion bioassay of insulin, quantitation of tumor-initiator systems in mouse skin, calculation of potentiating effects of a hormonal factor in an isolated strip of contracting stomach muscle, etc.
Nitrous acid sodium salt. Used in many industrial processes, in meat curing, coloring, and preserving, and as a reagent in ANALYTICAL CHEMISTRY TECHNIQUES. It is used therapeutically as an antidote in cyanide poisoning. The compound is toxic and mutagenic and will react in vivo with secondary or tertiary amines thereby producing highly carcinogenic nitrosamines.
Cellulose derivative used in chromatography, as ion-exchange material, and for various industrial applications.
Techniques used to separate mixtures of substances based on differences in the relative affinities of the substances for mobile and stationary phases. A mobile phase (fluid or gas) passes through a column containing a stationary phase of porous solid or liquid coated on a solid support. Usage is both analytical for small amounts and preparative for bulk amounts.
Differentiation of the gene clusters encoding botulinum neurotoxin type A complexes in Clostridium botulinum type A, Ab, and A(B) strains. (1/8)We describe a strategy to identify the clusters of genes encoding components of the botulinum toxin type A (boNT/A) complexes in 57 strains of Clostridium botulinum types A, Ab, and A(B) isolated in Italy and in the United States from different sources. Specifically, we combined the results of PCR for detecting the ha33 and/or p47 genes with those of boNT/A PCR-restriction fragment length polymorphism analysis. Three different type A toxin gene clusters were revealed; type A1 was predominant among the strains from the United States, whereas type A2 predominated among the Italian strains, suggesting a geographic distinction between strains. By contrast, no relationship between the toxin gene clusters and the clinical or food source of strains was evident. In two C. botulinum type A isolates from the United States, we recognized a third type A toxin gene cluster (designated type A3) which was similar to that previously described only for C. botulinum type A(B) and Ab strains. Total genomic DNA from the strains was subjected to pulsed-filed gel electrophoresis and randomly amplified polymorphic DNA analyses, and the results were consistent with the boNT/A gene clusters obtained. (+info)
Efficient DNA fingerprinting of Clostridium botulinum types A, B, E, and F by amplified fragment length polymorphism analysis. (2/8)Amplified fragment length polymorphism (AFLP) analysis was applied to characterize 33 group I and 37 group II Clostridium botulinum strains. Four restriction enzyme and 30 primer combinations were screened to tailor the AFLP technique for optimal characterization of C. botulinum. The enzyme combination HindIII and HpyCH4IV, with primers having one selective nucleotide apiece (Hind-C and Hpy-A), was selected. AFLP clearly differentiated between C. botulinum groups I and II; group-specific clusters showed <10% similarity between proteolytic and nonproteolytic C. botulinum strains. In addition, group-specific fragments were detected in both groups. All strains studied were typeable by AFLP, and a total of 42 AFLP types were identified. Extensive diversity was observed among strains of C. botulinum type E, whereas group I had lower genetic biodiversity. These results indicate that AFLP is a fast, highly discriminating, and reproducible DNA fingerprinting method with excellent typeability, which, in addition to its suitability for typing at strain level, can be used for C. botulinum group identification. (+info)
Heterogeneity of times required for germination and outgrowth from single spores of nonproteolytic Clostridium botulinum. (3/8)Knowledge of the distribution of growth times from individual spores and quantification of this biovariability are important if predictions of growth in food are to be improved, particularly when, as for Clostridium botulinum, growth is likely to initiate from low numbers of spores. In this study we made a novel attempt to determine the distributions of times associated with the various stages of germination and subsequent growth from spores and the relationships between these stages. The time to germination (t(germ)), time to emergence (t(emerg)), and times to reach the lengths of one (t(C1)) and two (t(C2)) mature cells were quantified for individual spores of nonproteolytic C. botulinum Eklund 17B using phase-contrast microscopy and image analysis. The times to detection for wells inoculated with individual spores were recorded using a Bioscreen C automated turbidity reader and were compatible with the data obtained microscopically. The distributions of times to events during germination and subsequent growth showed considerable variability, and all stages contributed to the overall variability in the lag time. The times for germination (t(germ)), emergence (t(emerg) - t(germ)), cell maturation (t(C1) - t(emerg)), and doubling (t(C2) - t(C1)) were not found to be correlated. Consequently, it was not possible to predict the total duration of the lag phase from information for just one of the stages, such as germination. As the variability in postgermination stages is relatively large, the first spore to germinate will not necessarily be the first spore to produce actively dividing cells and start neurotoxin production. This information can make a substantial contribution to improved predictive modeling and better quantitative microbiological risk assessment. (+info)
Production of anti-neurotoxin antibody is enhanced by two subcomponents, HA1 and HA3b, of Clostridium botulinum type B 16S toxin-haemagglutinin. (4/8)Clostridium botulinum type B strain produces two forms of progenitor toxin, 16S and 12S. The 12S toxin is formed by association of a neurotoxin (NTX) and a non-toxic non-haemagglutinin (NTNH), and the 16S toxin is formed by conjugation of the 12S toxin with a haemagglutinin (HA). HA consists of four subcomponents designated HA1, HA2, HA3a and HA3b. When mice were immunized with formalin-detoxified NTX, 12S or 16S, a significantly greater amount of anti-NTX antibody (Ab) was produced in the mice injected with 16S than in NTX- or 12S-injected mice. Immunization with NTX mixed with HA1 and/or HA3b also increased the anti-NTX Ab production, whereas NTX mixed with HA2 did not, indicating that HA1 and HA3b have adjuvant activity. This was further confirmed by immunizing mice with human albumin (Alb) alone or Alb mixed with either HA1 or HA3b. When mouse-spleen cells were stimulated with NTX, 16S or different HA subcomponents, 16S, HA1, HA3b and the mixture of HA1 and HA3 significantly increased interleukin 6 (IL6) production compared with NTX alone. Transcription of IL6 mRNA was low after stimulation with NTX alone, but increased to 16S-stimulation levels when NTX was mixed with HA1 or HA3b. In flow cytometry using labelled Abs against CD3 and CD19, the percentage of CD19 cells was higher following stimulation with 16S or NTX mixed with HA1 or HA3b compared with stimulation with NTX. The percentage of CD3 cells remained unchanged. These results suggest strongly that HA1 and HA3b demonstrate adjuvant activity via increasing IL6 production. (+info)
Development of enrichment semi-nested PCR for Clostridium botulinum types A, B, E, and F and its application to Korean environmental samples. (5/8)An enrichment semi-nested PCR procedure was developed for detection of Clostridium botulinum types A, B, E, and F. It was applied to sediment samples to examine the prevalence of C. botulinum in the Korean environment. The first pair of primers for the semi-nested PCR was designed using a region shared by the types A, B, E, and F neurotoxin gene sequences, and the second round employed four nested primers complementary to the BoNT/A, /B, /E, and /F encoding genes for simultaneous detection of the four serotypes. Positive results were obtained from the PCR analysis of five of 44 sediments (11%) collected from Yeong-am Lake in Korea; all were identified as deriving from type B neurotoxin (bontb) genes. Two of the C. botulinum type B organisms were isolated, and their bontb genes sequenced. The deduced amino acid sequences of BoNT/B showed 99.5 and 99.8% identity with the amino acid sequence of accession no. AB084152. Our data suggest that semi-nested PCR is a useful tool for detecting C. botulinum in sediments, and renders it practicable to conduct environmental surveys. (+info)
Bowel loops and eyelid droops. (6/8)(+info)
Comparative genomic hybridization analysis of two predominant Nordic group I (proteolytic) Clostridium botulinum type B clusters. (7/8)(+info)
Expression of Hc fragment from Clostridium botulinum neurotoxin serotype B in Escherichia coli and its use as a good immunogen. (8/8)A good immunogen was developed as an effective recombinant vaccine candidate that protected mice against botulinum neurotoxin serotype B (BoNT/B) intoxication. The Hc fragment of Clostridium botulinum neurotoxin type B (rBoNT/B-Hc) was cloned into the bacterial expression vector pQE-30, and the resulting vector was successfully expressed in the Escherichia coli M15 strain. The purified rBoNT/B-Hc protein was used to vaccinate mice and evaluate their survival against challenge with native BoNT/B. The mice that received three subcutaneous injections of rBoNT/B-Hc immunogen doses ranging from 0.25 to 6.25 mug mixed with Freund's adjuvant were completely protected against an intraperitoneal (i.p.) administration of 10,000 50% lethal doses (LD50) of BoNT/B. A dose response was observed in both the ELISA antibody titers and protective efficacy with increasing dose of immunogen. The work presented here demonstrates that the purified rBoNT/B-Hc was a highly effective immunogen and able to protect against a high-dose neurotoxin challenge. (+info)
Nordimet «Nordic Group» - Felleskatalogen
Indikasjoner:Aktiv revmatoid artritt hos voksne. Polyartritt-former av alvorlig, aktiv juvenil idiopatisk artritt (JIA), når respons på NSAID ikke har
IM2353U - Beckman Coulter
The monoclonal antibody 1D3 was shown to be non-reactive with NK cells or monocytes but to be specific to polymorphonuclear leucocytes (PMNs). It recognizes an epitope specific to the FcγRIIIB molecule and was characterized as the sole antibody belonging to the CD16b cluster of differentiation. This antibody reacts with PMNs, irrespective of the neutrophil antigen (NA) phenotype, although it shows lower reactivity with NA2-homozygote PMNs as compared to NA1-homozygotes or NA1/NA2 heterozygotes ...
Bioline International Official Site (site up-dated regularly)
were collected during the day. Conventional PCR and semi-nested PCR assays were optimised. The detection limit of the technique for purified W. bancrofti DNA extracted from adult worms was 10 fg for the internal systems (WbF/Wb2) and 0.1 fg by using semi-nested PCR. The specificity of the primers was confirmed experimentally by amplification of 1 ng of purified genomic DNA from other species of parasites. Evaluation of the paired urine and serum samples by the semi-nested PCR technique indicated only two of the 20 tested individuals were positive, whereas the simple internal PCR system (WbF/Wb2), which has highly promising performance, revealed that all the patients were positive using both samples. This study successfully demonstrated the possibility of using the PCR technique on urine for the diagnosis of W. bancrofti infection ...
Human IL1R2 ELISA Kit | biobool.com
specificalPrinciple of the Assay,,The Human IL-1R2 ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of Human IL-1R2 in Cell Culture Supernatants, Serum. This assay employs an antibody specific for Human IL-1R2 coated on a 96-well plate. Standards and samples are pipetted into the wells and IL-1R2 present in a sample is bound to the wells by the immobilized antibody. The wells are washed and biotinylated anti-Human IL-1R2 antibody is added. After washing away unbound biotinylated antibody, HRP-conjugated streptavidin is pipetted to the wells. The wells are again washed, a TMB substrate solution is added to the wells and color develops in proportion to the amount of IL-1R2 bound. The Stop Solution changes the color from blue to yellow, and the intensity of the color is measured at 450 nm. Background/Introduction: Interleukin 1 receptor, type II (IL1R2) also known as CD121b (Cluster of Differentiation 121b) is an ...
detection limit for semi-nested polymerase chain reac | Open-i
: detection limit for semi-nested polymerase chain reaction (PCR). Line 1:molecular weight marker of 100 bp; 2-9: 10-fold dilution curve, 1 ng-0.1 fg;10: negati
RCSB PDB for 1FV3
1FV3: The crystal structure of tetanus toxin Hc fragment complexed with a synthetic GT1b analogue suggests cross-linking between ganglioside receptors and the toxin.
Theoretical Investigations of Diffusion and Clustering in Semiconductors
Density functional theory studies of two systems have been conducted: mechanisms of self-diffusion in Ge and clustering of B in Si. In the case of self-diffusion of Ge, we find for the vacancy mechanism within harmonic transition state theory a diffusion prefactor, which agrees well with experiment but the activation energy is under-estimated by nearly 1 eV when the PW91 functional is used. We propose a cluster correction procedure involving the hybrid B3LYP functional, which brings the activation energy to 3.2 eV, agreeing with experiment. The interstitial and exchange mechanisms contribute negligibly. The reaction pathway of B cluster formation in Si has been studied, with the cluster B3I2 being identified as an intermediary in the formation of B3I-, a dominant cluster. The dimmer method is found to be effective for finding transition states for complex systems. All of the steps identified to date have been shown to be diffusion limited.
Ab-initio molecular dynamics model for density, elastic properties and short range order of Co-Fe-Ta-B metallic glass thin films
Density, elastic modulus and the pair distribution function of Co-Fe-Ta-B metallic glasses were obtained by ab-initio molecular dynamics simulations and measured for sputtered thin films using X-ray reflectivity, nanoindentation and X-ray diffraction using high energy photons. The computationally obtained density of 8.19 g/cm3 for Co43Fe20Ta5.5B31.5 and 8.42 g/cm3 for Co45.5Fe24Ta6B24.5, as well as the Youngs moduli of 273 and 251 GPa, respectively, are consistent with our experiments and literature data. These data, together with the good agreement between the theoretical and the experimental pair distribution functions, indicate that the here established model is useful to describe density, elasticity and short range order of Co-Fe-Ta-B metallic glass thin films. Irrespective of the investigated variation in chemical composition, (Co,Fe)-B cluster formation and Co-Fe interactions are identified by density of states analysis. Strong bonds within the structural units and between the metallic ...
Aprotinin - Wikipedia
The drug aprotinin (Trasylol, previously Bayer and now Nordic Group pharmaceuticals), is a small protein bovine pancreatic trypsin inhibitor (BPTI), or basic trypsin inhibitor of bovine pancreas, which is an antifibrinolytic molecule that inhibits trypsin and related proteolytic enzymes. Under the trade name Trasylol, aprotinin was used as a medication administered by injection to reduce bleeding during complex surgery, such as heart and liver surgery. Its main effect is the slowing down of fibrinolysis, the process that leads to the breakdown of blood clots. The aim in its use was to decrease the need for blood transfusions during surgery, as well as end-organ damage due to hypotension (low blood pressure) as a result of marked blood loss. The drug was temporarily withdrawn worldwide in 2007 after studies suggested that its use increased the risk of complications or death; this was confirmed by follow-up studies. Trasylol sales were suspended in May 2008, except for very restricted research ...
Sequence Similarity - 1DFQ: THE HC FRAGMENT OF TETANUS TOXIN COMPLEXED WITH SIALIC ACID Sequence Similarity Report...
1DFQ: The structures of the H(C) fragment of tetanus toxin with carbohydrate subunit complexes provide insight into ganglioside binding.
Clostridium Botulinum Type E Toxoid Antikörper (DyLight 405) (ABIN4264006)
Reaktivität: Bakterien Wirt: Maus Klon: KBE144 Konjugat: DyLight 405 | Clostridium Botulinum Type E Toxoid Antikörper (ABIN4264006).
Clostridium Botulinum Type E Toxoid Antikörper (Alexa Fluor 700) (ABIN4263965)
Reaktivität: Bakterien Wirt: Maus Klon: BE3 Konjugat: Alexa Fluor 700 | Clostridium Botulinum Type E Toxoid Antikörper (ABIN4263965).
中国科学院南海海洋研究所机构知识库(SCSIO OpenIR): Species identification in salted products of red snappers by semi-nested PCR-RFLP based on the...
A molecular approach was developed to distinguish species of red snappers among commercial salted fish products. The specific fragments of the mitochondrial 12S rRNA gene, which were about 450bp, were obtained using the semi-nested polymerase chain reaction (semi-nested PCR). Subsequently, PCR arnplicons were sequenced, aiming to select restriction endonucleases that generated species-specific restriction fragment length polymorphism (RFLP) profiles. Discrimination of red snappers Lutjanus sanguineus, Lutjanus erythopterus from Lutjanus argentimaculatus, Lutjanus malabarius and other morphologically similar fishes such as Lethrinus leutjanus and Pinjalo pinjalo was feasible by one restriction digestion reaction with three endonucleases Hae III, Sca I and SnaB I, however, for discrimination of L. sanguineus and L. erythopterus, another restriction digestion reaction with single restriction endonuclease Mae II was needed. The semi-nested PCR-RFLP was demonstrated to be reliable in species ...
A severe case of infant botulism caused by Clostridium botulinum type A with concomitant intestinal viral infections. - PubMed...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
gi|153938254|ref|YP 001392563.1| from Clostridium botulinum F str. Langeland
Domain architecture, protein sequence and external database links and dcGO predictor for gi|153938254|ref|YP_001392563.1| from Clostridium botulinum F str. Langeland.
Gentaur Molecular :Meridian Life Science \ Rabbit A C. botulinum Type A \ B76900R
Gentaur molecular products has all kinds of products like :search , Meridian Life Science \ Rabbit A C. botulinum Type A \ B76900R for more molecular products just contact us
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The detection of a deletion in the type B neurotoxin gene of Clostridium botulinum A(B) strains by a two-step PCR
Differences between the type B neurotoxin gene sequence of Clostridium botulinum type A(B) and Cl. botulinum type B, including a six nucleotide deletion, were recently proposed as a cause of the lack of expression of this gene in the type A toxigenic strains. A polymerase chain reaction (PCR) based
Clostridium Botulinum | Renew Health And Wellness
Clostridium botulinum is a spore-forming, strictly anaerobic that means they live and grow in low oxygen environments, and gram-positive bacteria. The Clostridium botulinum bacteria remain dormant in the form of spores when conditions for survival are poor. The spore contains a small amount of all essential components of Clostridium botulinum, and has a thick protective …. ...
PDF] Clostridium botulinum by Christine Rasetti-Escargueil Download Book
Clostridium botulinum monoclonal antibody, clone KB22 - (MAB0406) - Products - Abnova
China Clostridium Botulinum Treatment, WorldinMFG.com
The structure of the neurotoxin-associated protein HA33/A from Clostridium botulinum suggests a reoccurring beta-trefoil fold...
The hemagglutinating protein HA33 from Clostridium botulinum is associated with the large botulinum neurotoxin secreted complexes and is critical in toxin protection, internalization, and possibly activation. We report the crystal structure of serotype A HA33 (HA33/A) at 1.5 A resolution that contains a unique domain organization and a carbohydrate recognition site. In addition, sequence alignments of the other toxin complex components, including the neurotoxin BoNT/A, hemagglutinating protein HA17/A, and non-toxic non-hemagglutinating protein NTNHA/A, suggests that most of the toxin complex consists of a reoccurring beta-trefoil fold ...
Clostridium botulinum - Wikipedia
Li clostrideye do botulisse, c est l microbe del famile des clostrideyes ki cåze li botulisse des djins et des biesses. No d l indje e sincieus latén : Clostridium botulinum ...
Clostridium Botulinum (Botulism) - Videos Liv
You said high pressure cooking can destroy the toxin? Does it destroy the toxin? Or just the bacteria? And if it destroys the toxin, can I just cook my bulgey can of food before I eat it?. Reply ...
health and safety in the health insurance and social proper care workplace Dissertation
1 . How Health and Safety legislation is usually implemented at work ( Learning Outcome 1) 2 . Many ways in which health insurance and safety requirements impact on
Comparative genomic hybridization analysis of adrenocortical t...
Comparative genomic hybridization analysis of adrenocortical tumors.: Comparative genomic hybridization (CGH) is a molecular cytogenetic technique that allows t
Recombination and insertion events involving the botulinum neurotoxin complex genes in Clostridium botulinum types A, B, E and...
Clostridium botulinum is a taxonomic designation for at least four diverse species that are defined by the expression of one (monovalent) or two (bivalent) of seven different C. botulinum neurotoxins (BoNTs, A-G). The four species have been classified as C. botulinum Groups I-IV. The presence of bont genes in strains representing the different Groups is probably the result of horizontal transfer of the toxin operons between the species. Chromosome and plasmid sequences of several C. botulinum strains representing A, B, E and F serotypes and a C. butyricum type E strain were compared to examine their genomic organization, or synteny, and the location of the botulinum toxin complex genes. These comparisons identified synteny among proteolytic (Group I) strains or nonproteolytic (Group II) strains but not between the two Groups. The bont complex genes within the strains examined were not randomly located but found within three regions of the chromosome or in two specific sites within plasmids. A
Grass Sickness and Clostridium Botulinum Type C
Grass sickness is an often fatal disease affecting horses especially in the springtime and leading to different signs of neurotoxicity. The pathogenesis still remains unclear, but there seems be a toxicoinfection with the neurotoxin-producing bacterium clostridium botulinum and the disease.
clostridium botulinum | I Love Pets
About Clostridium botulinum:. Clostridium botulinum can cause severe and potentially fatal toxicity in both animals consuming the pet treat and people handling the pet treat or coming in contact with contact areas that have been exposed to the product. Common symptoms may include dizziness, blurred or double vision, trouble with speaking or swallowing, difficulty breathing, muscle weakness, abdominal distension, and constipation. Pets or Persons experiencing these symptoms should seek immediate medical attention.. FIND OUT WHAT OTHER PET BRANDS MADE THE RECALL LIST:. ...
JoVE Author Search: Arnon SS
SWISS-MODEL Template Library | 3n7l.1
SWISS-MODEL Template Library (SMTL) entry for 3n7l.1. Crystal structure of botulinum neurotoxin serotype D/C VPI 5993 binding domain
List of foodborne illness outbreaks in the United States
Botulism (Type A Clostridium botulinum) in Peoria, Illinois. 28 persons were hospitalized, and 20 patients were treated with an ... "Outbreak of Botulism Type E Associated with Eating a Beached Whale - Western Alaska, July 2002". cdc.gov. Johnson, Annysa ( ... Mann JM, Martin S, Hoffman R, Marrazzo S (March 1981). "Patient recovery from type A botulism: morbidity assessment following a ... http://starpas.azcc.gov/scripts/cgiip.exe/WService=wsbroker1/names-detail.p?name-id=L12696489&type=L.L.C. Fox, Maggie (November ...
Myron W. Wentz
"Clostridium botulinum type F: Seasonal inhibition by Bacillus lichenoformis". Science 1967;155(758): 89-90. "Meet the Founder ...
Polyneuropathy in dogs and cats
"Natural Clostridium botulinum Type C Toxicosis in a Group of Cats". J Clin Microbiol. 42 (11): 5406-8. doi:10.1128/JCM.42.11. ... The most common type is Coonhound paralysis. This is similar to Guillain-Barré syndrome in humans. Coonhound paralysis seems to ... Hyperchylomicronemia or hyperlipoproteinemia is a type of inherited hyperlipidemia in cats. Polyneuropathy is caused by ...
... of the bacterium Clostridium botulinum. C. botulinum can fall into one of 7 different types which are strains A through G. Type ... Yule, Adam; Ian K. Barker; John W. Austin; Richard D. Moccia (2006). "Toxicity of Clostridium Botulinum Type E Neurotoxin to ... Franciosa, G; L. Fenicia; C. Caldiani; P. Aureli (1996). "PCR for detection of Clostridium botulinum type C in avian and ... The Type E strain is also commonly associated with avian outbreaks and is frequently found in fish species which is why most ...
... however the toxin produced from the bacterium Clostridium botulinum type C may be involved. Clostridium botulinum is a soil- ... It may cause grass sickness when the spores of C. botulinum type C are ingested and produce their toxin locally within the ... Grass sickness may affect all types of horse, pony and donkey, and has affected some well known horses including the ...
... is well known for its role in inhibiting the growth of Clostridium botulinum spores in refrigerated meats. The ... Furthermore, the type of bacteria also affects sodium nitrites effectiveness. It is generally agreed upon that sodium nitrite ... for this activity results from the inhibition of iron-sulfur clusters essential to energy metabolism of Clostridium botulinum. ... "Contribution of different vegetable types to exogenous nitrate and nitrite exposure". Food Chemistry. 120 (4): 960-966. doi: ...
Botulinum toxin is a neurotoxin protein produced by the bacterium Clostridium botulinum. Botox is a specific form of botulinum ... botulinum toxin type B) in type A-resistant cervical dystonia". Neurology. 53 (7): 1431-8. doi:10.1212/WNL.53.7.1431. PMID ... Botulinum toxin treats wrinkles by immobilizing the muscles which cause wrinkles. It is not appropriate for the treatment of ... Botulinum toxin Injectable filler Danby, FW (Jul-Aug 2010). "Nutrition and aging skin: sugar and glycation". Cln Dermatol. 4. ...
Many pathogenic bacteria, such as Staphylococcus aureusand Clostridium botulinum are food borne pathogens that secrete toxins ... Each of these different types of organisms can then be further classified as a pathogen based on its mode of transmission. This ... Each of these three types of antimicrobials can be classified into two subsequent groups: bactericidal and bacteriostatic. ...
"Sporulation of Clostridium botulinum Types A, B and E, Clostridium Perfringens, and putrefactive Anaerobe 3679 in dialysis sacs ... "Comparative Dose-Survival Curves of Representative Clostridium botulinum Type F Spores and Type A and B Spores", Applied and ... "Production of Types A and B Spores of Clostridium botulinum by the Biphasic Method: Effect on Spore Population, Radiation ... "Cryogenic Gamma Irradiation of Prototype Pork and Chicken and Antagonistic Effect between Clostridium botulinum Types A and B ...
Botulinum toxin infusion As an alternative to the deep digital flexor tenotomy, Clostridium botulinum type A toxin has been ... Carter, D; Renfroe (2009). "A Novel Approach to the Treatment and Prevention of Laminitis: Botulinum Toxin Type A for the ... Trimming Successful treatment for any type of founder must necessarily involve stabilization of the bony column by some means. ...
Clostridium perfringens, Clostridium botulinum, Streptococcus equi subspecies equi, Equine influenza, Equine herpesvirus type 1 ... Eight horses that had received prophylactic botulinum antitoxin and developed subsequent signs of Theiler's disease were ...
... specifically Clostridium botulinum in an effort to prevent botulism, and helps preserve the color of cured meat. Many also ... There are many types of curing salts often specific to a country or region. One of the most common curing salts. It is also ...
Tier 1 BSATs are indicated by an asterisk (*). Botulinum neurotoxin-producing species of Clostridium* Coxiella burnetii ... Alcelaphine herpesvirus type 1) Menangle virus Mycoplasma capricolum subspecies capripneumoniae (contagious caprine ... Abrin Botulinum neurotoxins* Clostridium perfringens epsilon toxin Conotoxins Ricin Saxitoxin Shiga-like ribosome inactivating ... proteins Shiga toxin Staphylococcal enterotoxins Tetrodotoxin 2 Type A trichothecenes: Diacetoxyscirpenol T-2 toxin Bacillus ...
Eric Robinson (veterinarian)
"The Bacteria of the Clostridium Botulinum C and D types". In 1929 he was also director of the Bacterial Vaccine Section at ...
H7 and Clostridium botulinum, the toxin genes in an integrated phage converted a harmless ancestral bacterium into a lethal ... This environmentally important trait can be found in most bacteria of the metabolic types listed above. Regardless of the type ... There are many types of antibiotics and each class inhibits a process that is different in the pathogen from that found in the ... Many types of secretion systems are known and these structures are often essential for the virulence of pathogens, so are ...
According to further researches, the Clostridium botulinum strains isolated were mainly type A, with several cases of type B. ... FU, Si-Wu; WANG, Chen-Huai (2008). "An Overview of Type E Botulism in China". Biomedical and Environmental Sciences. 21 (4): ... The team also discovered that, the source of the botulinum was a local fermented food called mi song hu hu. They promoted the ... and they were eradicated soon after the identification of them as cases type A botulism. After the liberation of 1949, a ...
List of MeSH codes (B03)
Clostridium botulinum type A MeSH B03.300.390.400.200.160.100 --- Clostridium botulinum type B MeSH B03.300.390.400.200.160.150 ... Clostridium botulinum type C MeSH B03.300.390.400.200.160.200 --- Clostridium botulinum type D MeSH B03.300.390.400.200.160.250 ... Clostridium botulinum type E MeSH B03.300.390.400.200.160.300 --- Clostridium botulinum type F MeSH B03.300.390.400.200.160.350 ... Clostridium botulinum type A MeSH B03.510.415.400.200.160.100 --- Clostridium botulinum type B MeSH B03.510.415.400.200.160.150 ...
Botulin is produced by Clostridium botulinum and causes the deadly disease botulism. While patients may sometimes complain of ... which has replaced horse serum-type tetanus antitoxin in most of the developed world. Anatoxin "The Preparation and Testing of ... For example, the tetanus toxoid is derived from the tetanospasmin produced by Clostridium tetani. The latter causes tetanus and ...
... meats serve to reduce the risks of food poisoning from anaerobic bacteria such as species of Clostridium that release botulinum ... when some types begin to go rancid. Unopened oils can have a storage life of up to one year, but some types have a shorter ... Modern techniques of preparing meat for storage vary with the type of meat and special requirements of tenderness, flavour, ...
Some authors include Clostridium haemolyticum as Clostridium novyi type D. C novyi is closely related to Clostridium botulinum ... The toxins normally produced by the various types are shown in table 1 The alpha-toxin of Clostridium botulinum types C and D, ... Type strain of Clostridium novyi at BacDive - the Bacterial Diversity Metadatabase Biology portal. ... Moore WB (October 1968). "Solidified media suitable for the cultivation of Clostridium novyi type B". Journal of General ...
"Clostridium argentinense sp. nov.: A Genetically Homogeneous Group Composed of All Strains of Clostridium botulinum Toxin Type ... botulinum toxin group G, respectively. Like Cl. botulinum, Cl. argentinense produces botulin, a neurotoxin that causes botulism ... "Clostridium argentinense: Suen et al., 1988". National Center for Biotechnology Information (NCBI). "Clostridium argentinense ... Clostridium argentinense is an anaerobic, motile, gram-positive bacterium. Some bacilli now identified as Cl. argentinense were ...
... botulinum types A or B. C. botulinum type A was found to be present in soil samples from mountain areas of Victoria. Type-B ... 1988, Clostridium argentinense sp.nov.: a genetically homogeneous group composed of all strains of Clostridium botulinum type G ... Type A C. botulinum predominates the soil samples from the western regions, while type B is the major type found in eastern ... Clostridium Botulinum type A (most potent type) can be broken down and destroyed for 160 °f for 10 minutes, but they are ...
Clostridium botulinum type C toxin has been incriminated as the cause of grass sickness, a condition in horses which occurs in ... by the bacterium Clostridium botulinum. Clostridium botulinum is a large anaerobic Gram-positive bacillus that forms ... Clostridium botulinum is an anaerobic, Gram positive, spore-forming rod. Botulinum toxin is one of the most powerful known ... However, further studies showed type H to be a chimeric toxin composed of parts of types F and A (FA). Some types produce a ...
The bacterium responsible, Clostridium botulinum, is ubiquitous in the environment, grows in the anaerobic conditions created ... Emulsion-type cooked sausages, such as frankfurters or bologna, use a bowl chopper to make finely ground meat batter that is ... Nitrites are used for all types of sausages and are the most common. Nitrates are used only in the preparation of the cured dry ... Sausages come in two main types: fresh and cured. Cured sausages may be either cooked or dried. Most cured sausages are smoked ...
"Clostridium baratii". Retrieved 2011-01-24. Type strain of Clostridium baratii at BacDive - the Bacterial Diversity ... As opposed to the classic cause of botulism, C. botulinum, its environmental source is unknown. Therefore, it is unclear how to ... "Clostridium baratii: Prévot 1938". National Center for Biotechnology Information (NCBI). Clostridium baratii at the ... Infant Botulism Caused by Clostridium baratii Type F - Iowa, 2013". MMWR. Centers for Disease Control and Prevention. Retrieved ...
Botulism is a rare disease caused by the bacterium Clostridium botulinum.This microbe is primarily found in the soil or ... According to studies, there is an estimated 60,000 different types of bacteria that reside in the soil. Terrestrial bacteria ...
There are eight types of botulinum toxin, named type A-H. Type A and B are capable of causing disease in humans, and are also ... Botulinum toxin produced by Clostridium botulinum is the cause of botulism. Humans most commonly ingest the toxin from eating ... Botulinum toxin (BTX) is a neurotoxic protein produced by the bacterium Clostridium botulinum and related species. It prevents ... Types C-G are less common; types E and F can cause disease in humans, while the other types cause disease in other animals. ...
... and Southern blot hybridisation for type E botulinum toxin gene. The absence of genes encoding botulinum neurotoxin A,B,F and ... "Inhibition of the cytotoxic effect of Clostridium difficile in vitro by Clostridium butyricum MIYAIRI 588 strain". Journal of ... Clostridium butyricum is a strictly anaerobic endospore-forming Gram-positive butyric acid producing bacillus subsisting by ... of a neurotoxigenic Clostridium butyricum strain isolated from the food implicated in an outbreak of food-borne type E botulism ...
Biosecurity in the United States
Bacillus anthracis Botulinum neurotoxin Botulinum neurotoxin producing species of Clostridium Brucella abortus Brucella ... Alcelaphine herpesvirus type 1) Menangle virus Mycoplasma capricolum/ M.F38/M. mycoides Capri (contagious caprine ... Clostridium perfringens epsilon toxin Coccidioides immitis Coxiella burnetii Eastern equine encephalitis virus Francisella ...
Well-known exotoxins include: botulinum toxin produced by Clostridium botulinum; Corynebacterium diphtheriae toxin, produced ... toxic effectors of type VI secretion system) By tissue target type susceptible to the toxin (neurotoxins affect the nervous ... Type III exotoxins can be classified by their mode of entry into the cell, or by their mechanism once inside. Intracellular ... Toxins of this type include cholera toxin, pertussis toxin, Shiga toxin and heat-liable enterotoxin from E. coli. Once in the ...
Clostridia. Clostridium (spore-forming). motile:. *Clostridium difficile *Pseudomembranous colitis. *Clostridium botulinum * ... Type strain of Streptococcus pneumoniae at BacDive - the Bacterial Diversity Metadatabase ... The organism also causes many types of pneumococcal infections other than pneumonia. These invasive pneumococcal diseases ... induction of transformation by a desoxyribonucleic acid fraction isolated from pneumococcus type III". J Exp Med. 79 (2): 137- ...
Urinary tract infection
Clostridia. Clostridium (spore-forming). motile:. *Clostridium difficile *Pseudomembranous colitis. *Clostridium botulinum * ... Lam, TB; Omar, MI; Fisher, E; Gillies, K; MacLennan, S (23 September 2014). "Types of indwelling urethral catheters for short- ... the type of underwear used, personal hygiene methods used after urinating or defecating, or whether a person typically bathes ...
Fermentation in food processing
... as the Clostridium botulinum bacteria thrive in the anaerobic conditions created by the air-tight enclosure in plastic. ... Fermented foods by typeEdit. Bean-basedEdit. Cheonggukjang, doenjang, fermented bean curd, miso, natto, soy sauce, stinky tofu ...
... that prevented Clostridium botulinum growth. ... This method is the most traditional and ancient type of ...
Toxin tiếng Việt
Clostridium: tetani (Tetanospasmin) · perfringens (Alpha toxin, Enterotoxin) · difficile (A, B) · botulinum (Botox). khác: ... type I (Superantigen) · type II (Pore forming toxins) · type III (AB toxin/AB5) ...
... that prevented Clostridium botulinum growth. ... This method is the most traditional and ancient type of ...
... includes the genus Clostridium (e.g. the pathogens C. dificile, C. tetani, C. botulinum and the biotech C. acetobutylicum) ... but generally the name of the phylum is generally the plural of the type genus, with the exception of the Firmicutes, ... Low-G+C species (later renamed Firmicutes) (Clostridium, Peptococcus, Bacillus, Mycoplasma) ... the class Clostridia of mostly anaerobic sulphite-reducing saprophytic species, ...
Bakteri bahasa Indonesia, ensiklopedia bebas
High-Pressure-Mediated Survival of Clostridium botulinum and Bacillus amyloliquefaciens Endospores at High Temperature. Appl ... Filament of the Extreme Halophile Halobacterium salinarum R1M1 and Its Relation to Eubacterial Flagellar Filaments and Type IV ... Clostridium botulinum merupakan salah satu contoh bakteri penghasil endospora yang sangat tahan suhu dan tekanan tinggi, dimana ... Clostridium botulinum, menghasilkan racun botulinin, seringkali terdapat pada makanan kalengan dan kini senyawa tersebut ...
Clostridia. Clostridium (spore-forming). motile:. *Clostridium difficile *Pseudomembranous colitis. *Clostridium botulinum * ... Tetanus affects skeletal muscle, a type of striated muscle used in voluntary movement. The other type of striated muscle, ... Tetanus is caused by the tetanus bacterium Clostridium tetani. Tetanus is an international health problem, as C. tetani ... Tetanus, also known as lockjaw, is an infection characterized by muscle spasms. In the most common type, the spasms begin in ...
"A novel strain of Clostridium botulinum that produces type B and type H botulinum toxins". The Journal of Infectious Diseases. ... There are seven main types of botulinum toxin, named type A-G. New types are occasionally found. Types A and B are ... types E and F can cause disease in humans, while the other types cause disease in other animals. Botulinum toxin types A and ... Botulism toxins are produced by bacteria of the genus Clostridium, namely Clostridium botulinum, C. butyricum, C. baratii and C ...
Clostridium:. *tetani *Tetanospasmin. *Tetanolysin. *perfringens *Alpha toxin. *Enterotoxin. *difficile *A. *B. *botulinum * ... type I *Superantigen. *type II *Pore-forming toxin. *type III *AB toxin/AB5 ...
Properly cured sauerkraut is sufficiently acidic to prevent a favorable environment for the growth of Clostridium botulinum, ... There is also a home made type of very mild sauerkraut where white cabbage is pickled with salt in a refrigerator for only ... see http://www.mariner.org/exploration/index.php?type=webpage&id=55 / What did they eat? which begins "One of Cook's most ...
Clostridium botulinum (which can survive anaerobic conditions and high temperatures and is thus not always affected by ... It is now common for other types of vinegar (made from wine, rice and apple cider) to be sold mixed with cane vinegar to lower ... A white variation has become quite popular in Brazil in recent years, where it is the cheapest type of vinegar sold. ... Vinegar is effective in removing clogs from drains, polishing silver, copper and brass as well as ungluing sticker-type price ...
Clostridia. Clostridium (spore-forming). motile:. *Clostridium difficile *Pseudomembranous colitis. *Clostridium botulinum * ... The type species is B. subtilis, an important model organism. It is also a notable food spoiler, causing ropiness in bread and ... "Nucleotide sequence of the sspE genes coding for γ-type small, acid-soluble spore proteins from the round-spore-forming ... "The All-Species Living Tree project: A 16S rRNA-based phylogenetic tree of all sequenced type strains" (PDF). Systematic and ...
Botulinum toxin (from Clostridium botulinum) and bleomycin (from Streptomyces verticillus) are two examples. Botulinum, the ... A more recent example is the N-type calcium channel blocker ziconotide analgesic which is based on a cyclic peptide cone snail ... C2 symmetry tends to be much more abundant than other types of bilateral symmetry. This finding sheds light on how these ... This apparent contradiction was later solved by Berzelius's theory of isomers, whereby not only the number and type of elements ...
Major types and their metabolites. Aflatoxin B1 is considered the most toxic and is produced by both Aspergillus flavus ... Clostridium:. *tetani *Tetanospasmin. *Tetanolysin. *perfringens *Alpha toxin. *Enterotoxin. *difficile *A. *B. *botulinum * ... However the most toxic type of aflatoxin, B1, can permeate through the skin. ... but it invades all types of organic substrates whenever conditions are favorable for its growth. Favorable conditions include ...
Lamanna C, McElroy OE, Eklund HW (May 1946). "The purification and crystallization of Clostridium botulinum type A toxin". ... There are eight types of botulinum toxin, named type A-H. Types A and B are capable of causing disease in humans, and are also ... Botulinum toxin (BTX) or Botox is a neurotoxic protein produced by the bacterium Clostridium botulinum and related species. ... Botulism toxins are produced by bacteria of the genus Clostridium, namely Clostridium botulinum, C. butyricum, C. baratii and C ...
Clostridia. Clostridium (spore-forming). motile:. *Clostridium difficile *Pseudomembranous colitis. *Clostridium botulinum * ... Myonecrosis differs slightly from other types of necrosis. While the underlying causes are almost identical, the type of ... Gas gangrene is caused by exotoxin-producing Clostridium species (most often C. perfringens, and C. novyi, but less commonly ... Chi CH, Chen KW, Huang JJ, Chuang YC, Wu MH (1995). "Gas composition in Clostridium septicum gas gangrene". J Formos Med Assoc ...
Understanding the hazards associated with the main types of food and the conditions to prevent the growth of bacteria which can ... Clostridium botulinum. Escherichia coli. Listeria. Salmonella. Vibrio cholerae. Cronobacter spp. Viral pathogens. ... "Food Safety and the Different Types of Food Contamination". Retrieved 2018-06-23.. ... "What are the different types of food contamination?". Retrieved 2018-06-10.. ...
Necrotoxins cause necrosis (i.e., death) in the cells they encounter and destroy all types of tissue. ... such as botulinum toxin). ... Clostridium:. *tetani *Tetanospasmin. *Tetanolysin. * ... Cytotoxins are toxic at the level of individual cells, either in a non-specific fashion or only in certain types of living ...
... is a type of labile toxin found in Escherichia coli and Bacillus cereus. ... Clostridium:. *tetani *Tetanospasmin. *Tetanolysin. *perfringens *Alpha toxin. *Enterotoxin. *difficile *A. *B. *botulinum * ... coli cells and A-type blood antigens. The importance of these binding events is not yet known. ...
Cell - Simple English Wikipedia, the free encyclopedia
use anaerobic respiration (e.g. Clostridium botulinum). Multicellular[change , change source]. Multicellular organisms are made ... Wikimedia Commons has media related to Cell types.. *↑ Alberts B. et al. 2002. Molecular biology of the cell. 4th ed, Garland. ...
List of infectious diseases
Clostridium botulinum; Note: Botulism is not an infection by Clostridium botulinum but caused by the intake of botulinum toxin ... Extranodal NK/T-cell lymphoma, nasal type. MCPyV Merkel-cell carcinoma. RNA virus. HCV Hepatocellular carcinoma. Splenic ...
Botulinum toxin is a neurotoxin protein produced by the bacterium Clostridium botulinum. Botox is a specific form of botulinum ... botulinum toxin type B) in type A-resistant cervical dystonia". Neurology. 53 (7): 1431-8. doi:10.1212/WNL.53.7.1431. PMID ... Botulinum toxin treats wrinkles by immobilizing the muscles which cause wrinkles. It is not appropriate for the treatment of ... Hyaluronic acid is a type of GAG that promotes collagen synthesis, repair, and hydration. GAGs serve as a natural moisturizer ...
"Isolation and characterization of a novel type of neurotoxic peptide from the venom of the South African scorpion Parabuthus ... Clostridium:. *tetani *Tetanospasmin. *Tetanolysin. *perfringens *Alpha toxin. *Enterotoxin. *difficile *A. *B. *botulinum * ...
List of parasites of humans
Clostridia. Clostridium (spore-forming). motile:. *Clostridium difficile *Pseudomembranous colitis. *Clostridium botulinum * ... Extranodal NK/T-cell lymphoma, nasal type. MCPyV Merkel-cell carcinoma. RNA virus. HCV Hepatocellular carcinoma. Splenic ... Schistosomiasis - bilharzia, bilharziosis or snail fever (all types) Schistosoma sp. Africa, Caribbean, eastern South America, ...
Cytotoxins are toxic at the level of individual cells, either in a non-specific fashion or only in certain types of living ... such as botulinum toxin). Toxins are largely secondary metabolites, which are organic compounds that are not directly involved ...
টক্সিন - উইকিপিডিয়া
... botulinum toxin (খাদ্যে বিষক্রিয়া এর মাধ্যমে হয়)) এই ধরনের টক্সিন ও দেখা যায়। ... type I *Superantigen. *type II *Pore-forming toxin. *type III *AB toxin/AB5 ...
The LD50 of this toxin has been measured to be approximately 2.5-3 ng/kg, making it second only to botulinum toxin (LD50 ... Tetanus toxin is an extremely potent neurotoxin produced by the vegetative cell of Clostridium tetani in anaerobic ... type I *Superantigen. *type II *Pore-forming toxin. *type III *AB toxin/AB5 ... Todar, Ken (2005). "Pathogenic Clostridia, including Botulism and Tetanus". Todar's Online Textbook of Bacteriology. Retrieved ...
F - Botulinum neurotoxin type F - Clostridium botulinum - F gene & protein
tr,Q57236,Q57236_CLOBO Botulinum neurotoxin type F OS=Clostridium botulinum OX=1491 GN=F PE=1 SV=1 ... Botulinum neurotoxin type FImported. Automatic assertion inferred from database entriesi ... IPR036248 Clostridium_toxin_transloc. IPR013320 ConA-like_dom_sf. IPR011065 Kunitz_inhibitor_STI-like_sf. IPR013104 Toxin_rcpt- ... IPR036248 Clostridium_toxin_transloc. IPR013320 ConA-like_dom_sf. IPR011065 Kunitz_inhibitor_STI-like_sf. IPR013104 Toxin_rcpt- ...
botF - Botulinum neurotoxin type F precursor - Clostridium botulinum - botF gene & protein
Precursor of botulinum neurotoxin F which may have 2 coreceptors; complex polysialylated gangliosides found on neural tissue ... Botulinum toxin causes flaccid paralysis by inhibiting neurotransmitter (acetylcholine) release from the presynaptic membranes ... sp,P30996,BXF_CLOBO Botulinum neurotoxin type F OS=Clostridium botulinum OX=1491 GN=botF PE=1 SV=1 ... Botulinum neurotoxin type F: Botulinum toxin causes flaccid paralysis by inhibiting neurotransmitter (acetylcholine) release ...
A novel strain of Clostridium botulinum that produces type B and type H botulinum toxins. - PubMed - NCBI
A novel strain of Clostridium botulinum that produces type B and type H botulinum toxins.. Barash JR1, Arnon SS. ... Clostridium botulinum strain IBCA10-7060, isolated from a patient with infant botulism, produced botulinum neurotoxin type B ( ... botulinum type Bh strain to be identified. BoNT/H is the first new botulinum toxin type to be recognized in ,40 years, and its ... Clostridium botulinum toxin statement from the director of the California Department of Public Health. [J Infect Dis. 2014] ...
A severe case of infant botulism caused by Clostridium botulinum type A with concomitant intestinal viral infections. - PubMed...
Publication type, MeSH terms, Substances. Publication type. *Case Reports. MeSH terms. *Botulinum Toxins, Type A/isolation & ... A severe case of infant botulism caused by Clostridium botulinum type A with concomitant intestinal viral infections.. Fenicia ...
Genetic Variation In Clostridium Botulinum, Types Of Botulism In France | 15109
Clostridium botuinum is a spore-forming bacterium, which produces potent neurotoxins (BoNT) and which is responsible for a ... Genetic variation in Clostridium botulinum, types of botulism in France. International Congress on Bacteriology & Infectious ... According to their immunological properties, BoNTs are divided into 7 types (A to G) and each type is generally synthesized by ... Type B botulism is traditional in our country subsequently to ingestion of contaminated pork meat products. However, in the ...
Clostridium botulinum neurotoxin type A, free from complexing proteins | CADTH.ca
Clostridium Botulinum Type E Toxoid Antikörper (DyLight 755) (ABIN4263961)
anti-Clostridium Botulinum Type E Toxoid Antikörper (DyLight 755) Clostridium Botulinum Type E Toxoid Antikörper (DyLight 755) ... Clostridium Botulinum Type E Toxoid Antikörper (ABIN4263961). ... Clostridium Botulinum Type E Toxoid Reaktivität Bakterien. ... C. Botulinum E toxoid. There is no cross-reactivity with A and B toxoids in sandwich ELISA. ...
Grass Sickness and Clostridium Botulinum Type C
... but there seems be a toxicoinfection with the neurotoxin-producing bacterium clostridium botulinum and the disease. ... botulinum type C toxicoinfection. Source: Hunter LC, Miller JK, Poxton IR. (1999): The association of Clostridium botulinum ... Grass sickness and clostridium botulinum type C Grass sickness is an often fatal disease affecting horses especially in the ... Clostridium botulinum was first implicated as a causative agent when it was isolated from the GI tract of a horse with EGS in ...
Neurotoxin gene profiling of clostridium botulinum types C and D native to different countries within Europe.
Clostridium botulinum types C and D, as well as their mosaic variants C-D and D-C, are associated with avian and mammalian ... 0/botulinum toxin type C; 0/botulinum toxin type D; EC 184.108.40.206/Botulinum Toxins ... botulinum types C (n = 12), C-D (n = 29), D (n = 5), and D-C (n = 10), other botulinum neurotoxin (BoNT)-producing Clostridium ... Clostridium botulinum types C and D, as well as their mosaic variants C-D and D-C, are associated with avian and mammalian ...
Antagonistic Effect on Clostridium botulinum Type E by Organisms Resembling It | Applied and Environmental Microbiology
Antagonistic Effect on Clostridium botulinum Type E by Organisms Resembling It. D. A. Kautter, S. M. Harmon, R. K. Lynt Jr., T. ... Antagonistic Effect on Clostridium botulinum Type E by Organisms Resembling It. D. A. Kautter, S. M. Harmon, R. K. Lynt Jr., T. ... botulinum type E and, to a lesser extent, C. perfringens and C. acetobutylicum, but not C. botulinum types A, B, or F, are ... Antagonistic Effect on Clostridium botulinum Type E by Organisms Resembling It. D. A. Kautter, S. M. Harmon, R. K. Lynt Jr., T ...
Clostridium botulinum Type B Neurotoxin polyclonal antibody - (PAB29146) - Products - Abnova
Native purified Clostridium botulinum Type B Neurotoxin emulsified in Freunds adjuvant. (PAB29146) - Products - Abnova ... Chicken polyclonal antibody raised against Clostridium botulinum Type B Neurotoxin. ... Clostridium botulinum Type B Neurotoxin polyclonal antibody. Clostridium botulinum Type B Neurotoxin polyclonal antibody. * ...
SYBR Green Real-Time PCR Method To Detect Clostridium botulinum Type A | Applied and Environmental Microbiology
The specificity of the method was tested against 75 strains of C. botulinum type A, 4 strains of C. botulinum type Ab, and 101 ... SYBR Green Real-Time PCR Method To Detect Clostridium botulinum Type A. Lucia Fenicia, Fabrizio Anniballi, Dario De Medici, ... Botulinum toxins (BoNTs) are classically produced by Clostridium botulinum but rarely also from neurotoxigenic strains of ... SYBR Green Real-Time PCR Method To Detect Clostridium botulinum Type A ...
The relation between toxicity and toxin-related-antigen contents of Clostridium botulinum types C and D cultures as determined...
Effects of Carbon Dioxide on Neurotoxin Gene Expression in Non-proteolytic Clostridium botulinum type E.
... Artin, Ingrid LU ; ... non-proteolytic Clostridium botulinum type E were studied during the growth cycle. Quantitative reverse transcription-PCR and ... non-proteolytic Clostridium botulinum type E were studied during the growth cycle. Quantitative reverse transcription-PCR and ... non-proteolytic Clostridium botulinum type E were studied during the growth cycle. Quantitative reverse transcription-PCR and ...
AID 664282 - Competitive inhibition of clostridium botulinum Botulinum neurotoxin type A light chain by RP-HPLC analysis -...
Dysport® (clostridium botulinum type A toxin-haemagglutinin complex) now approved in the UK for symptomatic treatment of upper...
Dysport® (clostridium botulinum type A toxin-haemagglutinin complex) now approved in the UK for symptomatic treatment of upper ... Dysport® is an injectable form of a botulinum neurotoxin type A product, which is a substance derived from Clostridium bacteria ... "Therapeutic options such as botulinum toxin type A are an important part of the multidisciplinary approach for treating ... producing botulinum toxin type A (BoNT-A) that inhibits the effective transmission of nerve impulses and thereby reduces ...
Monoclonal Antibody to Clostridium botulinum Type A Neurotoxin Heavy Chain (amino acids 1177-1195). - WB, EIA - Buy Now! ...
Monoclonal Antibody to Clostridium botulinum Type A Neurotoxin Heavy Chain (amino acids 1177-1195). , validated in WB, EIA ( ... Clostridium botulinum Type A Neurotoxin Heavy Chain (amino acids 1177-1195). Weak cross-reactivity with Type B and Type E ... Monoclonal Antibody to Clostridium botulinum Type A Neurotoxin Heavy Chain (amino acids 1177-1195). is for research use only ... Monoclonal Antibody to Clostridium botulinum Type A Neurotoxin Heavy Chain (amino acids 1177-1195). ...
The detection of a deletion in the type B neurotoxin gene of Clostridium botulinum A(B) strains by a two-step PCR
botulinum type B, including a six nucleotide deletion, were recently proposed as a cause of the lack of expression of this gene ... Differences between the type B neurotoxin gene sequence of Clostridium botulinum type A(B) and Cl. ... in the type A toxigenic strains. A polymerase chain reaction (PCR) based ... Differences between the type B neurotoxin gene sequence of Clostridium botulinum type A(B) and Cl. botulinum type B, including ...
KAKEN - Research Projects | STRUCTURE AND FUNCTION OF RECEPTOR FOR CLOSTRIDIUM BOTULINUM TYPE B NEUROTOXIN (KAKENHI-PROJECT...
Clostridium botulinum / neurotoxin / receptor. Research Abstract. Clostridium botulinum neurotoxin acts on nerve ending to ... Publications] Nishiki,T. et al.: Identification of protein receptor for clostridium botulinum type B neurotoxin in rat brain ... Publications] Nishiki,T. et al.: The high-affinity binding of clostridium botulinum type B neurotoxin to synaptotagmin II ... Publications] Nishiki T.,et al.: The high-affinity binding of Clostridium botulinum type B neurotoxin to synaptotagmin II ...
Honey sold directly by producers in the Silesian region of Poland as a source of Clostridium botulinum types A, B, E and F |...
Honey sold directly by producers in the Silesian region of Poland as a source of Clostridium botulinum types A, B, E and F , ... Honey sold directly by producers in the Silesian region of Poland as a source of Clostridium botulinum types A, B, E and F ... NEVAS M, LINDSTROM M, HAUTAMAKI K, PUOSKARI S, KORKEALA H (2005): Prevalence and diversity of Clostridium botulinum types A, B ... The major serotypes detected were type A - in two (5.1%) and type B - in two (5.1%) honey samples, respectively. Types E and F ...
Recombination and insertion events involving the botulinum neurotoxin complex genes in Clostridium botulinum types A, B, E and...
In C. botulinum type E and C. butyricum type E strains the location of the bont/e gene cluster appears to be the result of ... Chromosome and plasmid sequences of several C. botulinum strains representing A, B, E and F serotypes and a C. butyricum type E ... botulinum neurotoxins (BoNTs, A-G). The four species have been classified as C. botulinum Groups I-IV. The presence of bont ... have led to the lineages observed today within the neurotoxin-producing clostridia. ...
Clostridium botulinum neurotoxin - Stock Image - C035/8693 - Science Photo Library
This is botulinum neurotoxin type A (BoNT/A), one the toxins that causes the deadly paralytic illness botulism. ... Clostridium botulinum neurotoxin, molecular model showing secondary structure. ... Clostridium botulinum neurotoxin, molecular model showing secondary structure. This is botulinum neurotoxin type A (BoNT/A), ... It is produced by the bacterium Clostridium botulinum and is usually ingested in the form of contaminated food. Type A is used ...
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rplB - 50S ribosomal protein L2 - Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A) - rplB gene & protein
sp,A5I7K3,RL2_CLOBH 50S ribosomal protein L2 OS=Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A) OX=441771 ... Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A). ,p>This subsection of the ,a href="http://www.uniprot. ... cellular organisms › Bacteria › Terrabacteria group › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium › ... structural constituent of ribosome Source: GO_Central ,p>Inferred from Biological aspect of Ancestor,/p> ,p>A type of ...
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Sequence Similarity - 4HEV: Clostridium Botulinum Serotype A Light Chain Inhibited By Adamantane Hydroxamate Sequence...
Evaluation of adamantane hydroxamates as botulinum neurotoxin inhibitors: synthesis, crystallography, modeling, kinetic and ... Botulinum neurotoxin type A light chain 1491 220.127.116.11 , Details 23 4ZJX 1 A Botulinum neurotoxin type A 1491 18.104.22.168 , ... Botulinum neurotoxin type A residues 1-424 1491 22.214.171.124 , Details 44 2G7Q 1 A, B Botulinum neurotoxin type A Light Chain A, ... Botulinum neurotoxin type A residues 1-424 1491 126.96.36.199 , Details 34 3QJ0 1 A Botulinum neurotoxin type A light chain (UNP ...
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Inquire price of Dysport 500 I.U Injection composition of Clostridium botulinum type A toxin-haemagglutinin 500 I.U injection ... Composition : Clostridium botulinum type A toxin-haemagglutinin complex. Manufacturer: Bharat Serums and Vaccines Limited. Form ... Botulinum toxin type A). AbobotulinumtoxinA is made from the bacteria that causes botulism. Botulinum toxin blocks nerve ... You should not receive Dysport injecton if you are allergic to botulinum toxin or if you have an infection, swelling, or muscle ...
Activation of Some Clostridium botulinum Type D Toxin by Trypsin | Microbiology Society
... botulinum types C and D, the toxicity of C2 toxin, which is a minor toxin produced by both types C and D, is increased when the ... The present communication suggests that some strains of C. botulinum type D produce their major toxin in a form that may be ... Toxin produced by Clostridium botulinum types A, B, E and F may be activated by exposure to trypsin (Duff et al., 1956; ... Activation of Some Clostridium botulinum Type D Toxin by Trypsin * A. Nakane, K. Oguma and H. Iida ...
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... the first strain identified to produce botulinum neurotoxin type G (BoNT/G). Although discovered in 1970, to date, there have ... Analysis of a unique Clostridium botulinum strain from the Southern hemisphere producing a novel type E botulinum neurotoxin ... Recombination and insertion events involving the botulinum neurotoxin complex genes in Clostridium botulinum types A, B, E and ... Finished Whole-Genome Sequence of Clostridium argentinense Producing Botulinum Neurotoxin Type G Jessica L Halpin 1 , Karen ...
BotulismToxinsSporesStrainsBacteria Clostridium botulinumBacterium clostridium botulinumPerfringensNeurotoxinsBoNTButyricumOrganismDifficileSpeciesGeneBotoxAnaerobicProteinsMicrobiologyAspects of botulinum toxinProteolyticNeurotoxin that causesBoNTsATCCSerotypeVialDysportGenome sequenceMonoclonal AntibodyIntramuscularProducesPurificationAnaerobesGenomicClostridialDetectionMouse bioassayGenesInjections of botulinumIllnessComplexIntestinalGram-positiveVegetative growthIsolatesAcetylcholineToxin knownToxoid
- Clostridium botulinum strain IBCA10-7060, isolated from a patient with infant botulism, produced botulinum neurotoxin type B (BoNT/B) and another BoNT that, by use of the standard mouse bioassay, could not be neutralized by any of the Centers for Disease Control and Prevention-provided monovalent polyclonal botulinum antitoxins raised against BoNT types A-G. (nih.gov)
- A severe case of infant botulism caused by Clostridium botulinum type A with concomitant intestinal viral infections. (nih.gov)
- Clostridium botuinum is a spore-forming bacterium, which produces potent neurotoxins (BoNT) and which is responsible for a severe flaccid paralysis (botulism) in man and animals. (omicsonline.org)
- Type B botulism is traditional in our country subsequently to ingestion of contaminated pork meat products. (omicsonline.org)
- However, in the recent years, human botulism was more diverse, and type A botulism outbreaks were predominant. (omicsonline.org)
- Clostridium botulinum types C and D, as well as their mosaic variants C-D and D-C, are associated with avian and mammalian botulism. (biomedsearch.com)
- These PCR assays were compared to previously published real-time PCRs for the detection of C. botulinum in 292 samples collected from cases of botulism events in four European regions. (biomedsearch.com)
- BoNT type A (BoNT/A), BoNT/B, BoNT/E, and very rarely BoNT/F are mainly responsible for human botulism. (asm.org)
- Bianco M.I., Luquez C., de Jong L.I.T., Fernanadez R.A. (2009): Linden flower (Tilia spp) as potential vehicle of Clostridium botulinum spores in the transmission of infant botulism. (agriculturejournals.cz)
- Production of BoNT has been the single criterion for inclusion within the C. botulinum species and was adopted in order to prevent scientific and medical confusion regarding the intoxication known as botulism. (biomedcentral.com)
- This is botulinum neurotoxin type A (BoNT/A), one the toxins that causes the deadly paralytic illness botulism. (sciencephoto.com)
- Dysport is an injection containing abobotulinumtoxinA (Botulinum toxin type A). AbobotulinumtoxinA is made from the bacteria that causes botulism. (oddwayinternational.com)
- C. butyricum strains atypically producing the botulinum neurotoxin type E are the leading cause of type E human botulism in Italy. (asm.org)
- IMPORTANCE Botulinum neurotoxins, the causative agents of the potentially fatal disease of botulism, are produced by certain Clostridium strains during vegetative growth, usually in anaerobic environments. (asm.org)
- It occurs as a result of intestinal colonization with Clostridium botulinum and in vivo toxin production in a manner similar to that of infant botulism. (inchem.org)
- In the United States, most Clostridium botulinum type A strains isolated during laboratory investigations of human botulism demonstrate the presence of an expressed type A botulinum neurotoxin (BoNT/A) gene and an unexpressed BoNT/B gene. (beds.ac.uk)
- Botulism is a paralytic disease caused by the action of botulinum neurotoxins (BoNT) at neuromuscular junctions. (beds.ac.uk)
- Between 2010 and 2013, 47 C. botulinum type A strains were isolated during 36 laboratory investigations of botulism at the Centers for Disease Control and Prevention (CDC). (beds.ac.uk)
- Among these strains, 86% were determined to possess an unexpressed BoNT/B gene suggesting that type A(B) strains are common among US botulism cases (unpublished data). (beds.ac.uk)
- Editorial Note: Wound botulism, first described in association with traumatic injury, is a rare illness that occurs after spores of C. botulinum have germinated in a wound and produced botulinal toxin, resulting in flaccid paralysis (1). (cdc.gov)
- Here we present the first complete genome of a C. botulinum strain from physiological group III, causing animal botulism. (biomedcentral.com)
- Botulism is a paralytic disease caused by some of the most potent toxins known, the botulinum neurotoxins (BoNTs). (biomedcentral.com)
- As spores, the bacteria usually remain relatively harmless, but when they are activated and resume growth, the bacteria release several different types of potent neurotoxins that can cause the paralyzing disease botulism. (kenyon.edu)
- While all forms of the toxin are destructive, types A, B, E, and F are known to specifically cause botulism in humans, while types C and D are associated with animal botulism. (kenyon.edu)
- Types A and B mainly cause infant botulism, but types C, E, F, and G have also been identified as causative agents. (kenyon.edu)
- Group III contains toxins type C and D and are most commonly associated with botulism in animals. (kenyon.edu)
- Clostridium botulinum, which causes botulism. (prezi.com)
- The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. (jcvi.org)
- Of the many types of foodborne illnesses, botulism is one of the most dangerous. (webmd.com)
- Botulism is caused by the bacterium Clostridium botulinum ( C. botulinum ). (webmd.com)
- This type of botulism is associated with drug users who inject black tar heroin into their skin rather than their veins. (webmd.com)
- Some people have had this type of botulism after getting counterfeit Botox treatments. (webmd.com)
- It's the same toxin that causes a life-threatening type of food poisoning called botulism . (medlineplus.gov)
- Clostridium botulinum is a Gram-positive , anaerobic , rod-shaped bacterium that produces toxins (in particular neurotoxins), which cause the serious disease botulism . (thermofisher.com)
- There are no recorded outbreaks of Type G botulism. (thermofisher.com)
- an uncategorised form of botulism in adults which occurs when C. botulinum spores invade the intestinal tract, releasing toxin in vivo . (thermofisher.com)
- 2009. The recombinant Hc subunit of Clostridium botulinum neurotoxin serotype A is an effective botulism vaccine candidate. (kenyon.edu)
- 2004. Clostridium botulinum and the Clinical Laboratorian: A detailed review of botulism, including biological warfare ramifications of botulinum toxin. (kenyon.edu)
- Clostridium botulinum is also rod-shaped, endospore-forming, and responsible for producing the neurotoxin that causes botulism. (kenyon.edu)
- Clostridium botulinum is mostly found in marine-sediments and soils all over the world, as evidenced by cases of botulism that have been reported in Europe, North America, and Australia (Sugiyama 1980). (kenyon.edu)
- Clostridium botulinum causes the disease botulism, which was given the name after an outbreak of the disease in the 1700's where all of the people who were infected had eaten from the same large sausage. (kenyon.edu)
- More interestingly, Clostridium botulinum can only produce the neurotoxin responsible for causing botulism during sporulation, which can only occur in favorable environments. (kenyon.edu)
- 1996). There are three general modes through which a person could be infected with Clostridium botulinum , the neurotoxin it produces, and the resulting disease, botulism. (kenyon.edu)
- This is the least common form of botulism which is caused by Type A botulinin. (nursingcrib.com)
- Infant botulism is caused by consuming the spores of the botulinum bacteria, which then grow in the intestines and release toxin. (empowher.com)
- The most direct way to confirm the diagnosis is to demonstrate the botulinum toxin in the patient's serum or stool by injecting serum or stool into mice and looking for signs of botulism. (empowher.com)
- Nitrites are added during processing to act as preservatives and as antibacterial agents against clostridium botulinum, the toxin that causes botulism. (wikipedia.org)
- The story of four people hospitalized for botulism poisoning after receiving what they thought were Botox (botulinum toxin type A) injections at a Florida clinic has been followed closely in the media. (medpagetoday.com)
- Clostridium botulinum - which is Bird Botulism, a neurotoxin. (abovetopsecret.com)
- Botulism is a serious illness caused by the botulinum toxin. (medicalnewstoday.com)
- All types of botulism eventually lead to paralysis, so any case of botulism is treated as a medical emergency. (medicalnewstoday.com)
- The signs and symptoms depend on the type of botulism. (medicalnewstoday.com)
- There are several types of botulism. (medicalnewstoday.com)
- Foodborne botulism is caused by consuming foods containing the botulinum toxin. (medicalnewstoday.com)
- Injection drug users are at risk for this type of botulism. (medicalnewstoday.com)
- This is the medical name for botulism: a rare but serious form of food poisoning which is caused by a toxin released by the clostridium botulinum bacterium. (medic8.com)
- Botulism is an infrequent, but serious, illness caused by a germ called '"Clostridium Botulinum. (wikihow.com)
- There are three types of botulism- foodborne infection, wound infection, and infant botulism. (wikihow.com)
- All types of botulism can be fatal and should always be considered a medical emergency. (wikihow.com)
- BabyBIG is a product licensed to treat type A & B infant botulism cases and is only available through the California Department of Public Health, Infant Botulism Treatment and Prevention Program (IBTPP). (wyo.gov)
- Botulism is a dangerous disease caused by infection with the bacteria Clostridium botulinum . (news-medical.net)
- Food-borne botulism - Food can get contaminated with C. botulinum from infected soil. (news-medical.net)
- Wound botulism - This occurs when a wound gets infected with C. botulinum due to sniffing or injecting contaminated drugs. (news-medical.net)
- The neurological symptoms of wound botulism can take longer to develop than in food-borne botulism, although they are similar between the two types. (news-medical.net)
- Botulism may be suspected based on a patient's symptoms and the details they give of any possible exposure to C. Botulinum . (news-medical.net)
- Over the past four years dozens of similar outbreaks have occurred, all involving type E botulism, a rare strain of the potent nerve toxin. (nytimes.com)
- The botulism causing the fish and bird kills is a rare type of the bacteria clostridium botulinum. (nytimes.com)
- Type A botulism is the active ingredient in Botox, the drug that is injected in fashionable foreheads to paralyze the frown lines of aging. (nytimes.com)
- A novel strain of Clostridium botulinum that produces type B and type H botulinum toxins. (nih.gov)
- Botulinum toxins (BoNTs) are classically produced by Clostridium botulinum but rarely also from neurotoxigenic strains of Clostridium baratii and Clostridium butyricum . (asm.org)
- 3) Diffusion: has the least diffusion among all botulinum toxins currently known. (beautifox.uk)
- However, the incubation period is much longer (4 to 14 days), as time is required for the incubation of spores, growth of Clostridium, and release of toxins. (inchem.org)
-  Botulinum toxins have been used off-label for several pediatric conditions, including infantile esotropia . (wikipedia.org)
- The toxins are proteins mainly produced by the species Clostridium botulinum but some Clostridium butyricum and Clostridium baratii strains are also capable of producing BoNTs. (biomedcentral.com)
- Physiological group I (proteolytic) includes C. botulinum strains producing toxins of serotype A, B or F and is mainly associated with human cases. (biomedcentral.com)
- Dairy food-borne diseases affecting human health are associated with certain strains of bacteria belonging to the genera of Clostridium, Bacillus, Escherichia, Staphylococcus and Listeria, which are capable of producing toxins, plus moulds that can produce mycotoxins such as aflatoxins, sterigmatocytin and ochratoxin. (wiley.com)
- Clostridium botulinum can produce up to seven different types of toxins named with the letters A-G. The neurotoxins most usually infect individuals by contaminating canned or unrefrigerated food, infecting a wound, or entering a key water source. (kenyon.edu)
- Group II consists of Clostridium botulinum that produces type B, E, and F toxins and is also mostly found in contaminated food products. (kenyon.edu)
- Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. (jcvi.org)
- Most C. botulinum strains produce a single toxin but there have been reports of strains which have the capability to produce two or more toxins. (thermofisher.com)
- The protocol aims to address the basic mechanisms of Clostridium difficile pathogenesis by identifying how Clostridium difficile toxins inhibit eosinophils that otherwise would protect the. (bioportfolio.com)
- Alternative to animal use for detecting biologically active Staphylococcal enterotoxin type A. Toxins. (usda.gov)
- Infants aged older than one year have bacteria in their gut that prevent C. botulinum from producing the toxins. (news-medical.net)
- The various botulinum toxins possess individual potencies and care is required to assure proper use and avoid medication errors. (medscape.com)
- A bacteriocin-like substance, active against strains of Clostridium botulinum type E, is produced by certain nontoxic organisms whose biochemical properties and morphological characteristics are similar to type E. The substance, for which the name "boticin E" is proposed, is bacteriolytic for vegetative cells and bacteriostatic for spores of type E. Its spectrum of activity is somewhat strain-specific. (asm.org)
- The level of contamination of honey with Clostridium botulinum spores is considered as an indicator of the adequacy of hygienic practices during collection, extraction, and subsequent processing. (agriculturejournals.cz)
- A total of 39 honey samples purchased directly from beekeepers at outdoor markets and from small amateur apiaries in Silesia were analysed for Clostridium botulinum spores. (agriculturejournals.cz)
- The analysis showed six (15.4%) samples to be contaminated with C. botulinum spores. (agriculturejournals.cz)
- Küplülü Özlem, Göncüoğlu Muammer, Özdemir Haydar, Koluman Ahmet (2006): Incidence of Clostridium botulinum spores in honey in Turkey. (agriculturejournals.cz)
- Bacteria of the genus Clostridium are conventionally defined as obligate anaerobes, i.e., they have an oxygen-independent metabolism and could be killed by exposure to oxygen or form resistant spores that germinate into vegetative cells when the conditions become favorable. (asm.org)
- Tissue and serum specimens obtained from the patient were positive for type A botulinal toxin by mouse bioassay, and histochemical staining of an excised abscess indicated the presence of spores and vegetative cells consistent with Clostridium botulinum. (cdc.gov)
- Most Clostridium botulinum spores reside on the surfaces of fruits, dairy products, vegetables, seafood, and various canned foods. (kenyon.edu)
- It was rapidly adopted as the thermal processing surrogate for proteolytic Clostridium botulinum ( 5 , 8 ) because of morphological similarity and nontoxigenicity and because the heat resistance of its spores exceeded that of C. botulinum spores ( 6 , 7 ). (asm.org)
- If babies up to about 6 months old swallow botulinum spores, the spores can germinate into bacteria. (webmd.com)
- Botulinum spores can get into open wounds and slowly reproduce, eventually releasing the toxin. (webmd.com)
- Whereas most endospore-forming microbes form spores to preserve cells during long periods of unfavorable environments, Clostridium botulinum is only capable of forming spores in anaerobic environments in which it thrives. (kenyon.edu)
- The presence of multiple nidi and the continual discharge of organic materials into the environment may contribute to the perpetuation of botulinum spores by which foods prepared form marine animals become contaminated. (arctichealth.org)
- C. botulinum produces spores that can survive in poorly preserved or canned foods. (medicalnewstoday.com)
- Babies aged under 1 year should not be given honey or corn syrup as these have been reported to contain the C.botulinum spores. (news-medical.net)
- The combining of antitoxins to neutralize the toxicity of known bivalent C. botulinum strains Ab, Ba, Af, and Bf also failed to neutralize the second BoNT. (nih.gov)
- C. botulinum strains are genetically and physiologically heterogeneous and are classified into 4 groups. (omicsonline.org)
- In addition, some atypical strains belong to two other Clostridium species (C. baratii and C. butyricum). (omicsonline.org)
- Certain strains produce two types of toxin, but in different proportions, and other contain two BoNT genes, one of them being mutated and silent. (omicsonline.org)
- The tests were performed with a large variety of bacterial strains, including C. botulinum types C (n = 12), C-D (n = 29), D (n = 5), and D-C (n = 10), other botulinum neurotoxin (BoNT)-producing Clostridium strains (n = 20), non-BoNT-producing clostridia (n = 20), and other bacterial species (n = 23), and showed a high specificity. (biomedsearch.com)
- The presumptive identification of the toxigenic strains together with the typing of BoNT has to be performed by mouse bioassay. (asm.org)
- The specificity of the method was tested against 75 strains of C. botulinum type A, 4 strains of C. botulinum type Ab, and 101 nontarget strains. (asm.org)
- botulinum type B, including a six nucleotide deletion, were recently proposed as a cause of the lack of expression of this gene in the type A toxigenic strains. (ovid.com)
- A polymerase chain reaction (PCR) based on two sets of primers was designed to investigate the absence of the 6-nucleotide sequence in the apparently unexpressed type B toxin gene of 42 strains of Cl. (ovid.com)
- two strains did not have the deletion and actually produced small amounts of type B toxin when tested by the mouse bioassay. (ovid.com)
- KOLUMAN Ahmet, MELİKOĞLU GÖLCÜ Berfin, DERİN Okan, ÖZKÖK Sibel, ANNIBALLI Fabrizio (2013): Clostridium botulinum in honey: prevalence and antibiotic susceptibility of isolated strains. (agriculturejournals.cz)
- Chromosome and plasmid sequences of several C. botulinum strains representing A, B, E and F serotypes and a C. butyricum type E strain were compared to examine their genomic organization, or synteny, and the location of the botulinum toxin complex genes. (biomedcentral.com)
- In C. botulinum type E and C. butyricum type E strains the location of the bont/e gene cluster appears to be the result of insertion events that split a rarA , recombination-associated gene, independently at the same location in both species. (biomedcentral.com)
- Phylogenetic analysis of 16S rrn genes of C. botulinum strains clearly separates them into four Groups (I-IV) and supports this historical classification scheme based upon biochemical and biophysical parameters [ 1 ]. (biomedcentral.com)
- The present communication suggests that some strains of C. botulinum type D produce their major toxin in a form that may be activated by trypsin. (microbiologyresearch.org)
- Analysis of neurotoxin cluster genes in Clostridium botulinum strains producing botulinum neurotoxin serotype A subtypes. (cdc.gov)
- Neurotoxin gene clusters in Clostridium botulinum type Ab strains. (cdc.gov)
- In the United States, some clinically significant strains produce toxin type A while also harboring a silent B gene. (cdc.gov)
- Finished Whole-Genome Sequences of Clostridium butyricum Toxin Subtype E4 and Clostridium baratii Toxin Subtype F7 Strains. (cdc.gov)
- Genomics of Clostridium botulinum group III strains. (cdc.gov)
- Here, we show that type E botulinum neurotoxin-producing C. butyricum strains growing exponentially were able to keep growing and producing toxin in vitro upon exposure to air, although less efficiently than under ideal oxygen-depleted conditions. (asm.org)
- Our findings indicate that, contrary to current understanding, the growth of neurotoxigenic C. butyricum strains and botulinum neurotoxin type E production can continue upon transfer from anaerobic to aerated conditions and that adaptation of strains to oxygenated environments requires global changes in proteomic and metabolic profiles. (asm.org)
- We hypothesize that aerotolerance might constitute an unappreciated factor conferring physiological advantages on some botulinum toxin-producing clostridial strains, allowing them to adapt to otherwise restrictive environments. (asm.org)
- Oxygen tolerance among clostridia has been attributed to the enzymatic ability of strains to consume oxygen from the medium and to defend themselves against the toxic effects of the reactive oxygen species (ROS) ( 2 , 4 , 16 ). (asm.org)
- These strains are designated type A(B). The most common pulsed-field gel electrophoresis (PFGE) pattern in the C. botulinum PulseNet database is composed of A(B) strains. (beds.ac.uk)
- The genome sequences of type A(B) strains evaluated in this study are closely related and cluster together compared to other available C. botulinum Group I genomes. (beds.ac.uk)
- In silico multilocus sequence typing (MLST) analysis (7-loci) was unable to differentiate any of the type A(B) strains isolated from seven different outbreak investigations evaluated in this study. (beds.ac.uk)
- This study confirms that type A(B) strains that share the same PFGE pattern also share closely-related genome sequences. (beds.ac.uk)
- However, compared to other methods evaluated in this study, a reference-free SNP analysis demonstrated optimal subtyping utility for type A(B) strains using de novo assembled genome sequences. (beds.ac.uk)
- All strains of C. botulinum that produce BoNT/A belong to Group I. Nucleotide sequencing of the genes encoding BoNT/A reveals the presence of several toxin subtypes (eg. (beds.ac.uk)
- 4 ] demonstrated that several type A(B) strains isolated in North America shared a high degree of genomic content. (beds.ac.uk)
- Clostridium botulinum strains can be divided into four physiological groups that are sufficiently diverged to be considered as separate species. (biomedcentral.com)
- C1 neurotoxin of Clostridium botulinum strains C-Stockholm (C-ST), C beta-Yoichi, C-468, CD6F, and C-CB19 and type D toxin of strains D-1873 and D-CB16 were purified by gel filtration, ion exchange, and affinity chromatographies. (ac.ke)
- Clostridium sporogenes PA 3679 is widely used as a nontoxigenic surrogate for proteolytic strains of Clostridium botulinum in the derivation and validation of thermal processes in food. (asm.org)
- To generate knowledge in this regard and provide a basis for exploring the relationships that exist between PA 3679 and proteolytic strains of C. botulinum , here we present a draft assembly of the genome of PA 3679. (asm.org)
- 85% match to type A1 botulinum neurotoxin (BoNT)-producing proteolytic C. botulinum strains. (asm.org)
- BLAST ( 1 ) results of the 16S rRNA gene sequence indicated 99 to 100% nucleotide similarity between PA 3679 and a number of proteolytic C. botulinum strains, as well as other C. sporogenes strains. (asm.org)
- The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin. (jcvi.org)
- Type A strains that cause gas gangrene produce toxin alpha (phospholypase C), theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. (jcvi.org)
Bacteria Clostridium botulinum1
Bacterium clostridium botulinum7
- The pathogenesis still remains unclear, but there seems be a toxicoinfection with the neurotoxin-producing bacterium clostridium botulinum and the disease. (vetcontact.com)
- It is produced by the bacterium Clostridium botulinum and is usually ingested in the form of contaminated food. (sciencephoto.com)
- It occurs when neuromuscular transmission is interrupted by a protein neurotoxin produced by the spore-forming, obligate anaerobic bacterium Clostridium botulinum . (inchem.org)
- Botulinum toxin ( Botox ) is a neurotoxic protein produced by the bacterium Clostridium botulinum and related species. (wikipedia.org)
- Botox is a drug made from a toxin produced by the bacterium Clostridium botulinum. (medlineplus.gov)
- The botulinum toxin, a poison produced by the bacterium Clostridium botulinum (C. botulinum) , is common in soil and exists in untreated water. (medicalnewstoday.com)
- Botox is a brand name for botulinum toxin type A. It's produced by the bacterium Clostridium botulinum. (cnn.com)
- Of the clostridial species tested, only C. botulinum type E and, to a lesser extent, C. perfringens and C. acetobutylicum , but not C. botulinum types A, B, or F, are sensitive. (asm.org)
- Unlike most other clostridia, C. perfringens is non-motile. (jcvi.org)
- These bacteria form part of the Clostridium genus which includes clostridium perfringens and clostridium difficile. (medic8.com)
- Clostridium perfringens causes about 970,000 illnesses every year. (poison.org)
- Botulinum neurotoxins: more and more diverse and fascinating toxic proteins. (nih.gov)
- Clostridium botulinum is a taxonomic designation for at least four diverse species that are defined by the expression of one (monovalent) or two (bivalent) of seven different C. botulinum neurotoxins (BoNTs, A-G). The four species have been classified as C. botulinum Groups I-IV. (biomedcentral.com)
- This species can be categorized into four genetically and physiologically distinct groups that all produce different types of neurotoxins. (kenyon.edu)
- This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. (jcvi.org)
- On the other hand, there is the threat that neurotoxins produced by Clostridium botulinum could be used as a method of bioterrorism. (kenyon.edu)
- The neurotoxins produced by Clostridium botulinum are characterized as belonging to a group of proteins linked by disulphide chain bridges. (kenyon.edu)
- A heptavalent F(ab')2 botulinum antitoxin A-G obtained from the US Army also did not neutralize the second BoNT. (nih.gov)
- The second BoNT thus fulfilled classic criteria for being designated BoNT/H. IBCA10-7060 is the first C. botulinum type Bh strain to be identified. (nih.gov)
- Moreover, each BoNT type is subdivided into several subtypes based on nucleotide sequence variations of their genes. (omicsonline.org)
- The aim of the present study was to investigate the hypothesis that EGS results from toxicoinfection with C. botulinum type C: growth of the bacterium in the GI tract with production of toxin (BoNT/C). (vetcontact.com)
- Ileum contents and faeces from horses with EGS were investigated for BoNT/C, and indirectly for the presence of C. botulinum type C, and compared with control samples from horses without EGS. (vetcontact.com)
- Interestingly, only BoNT mosaics, types C-D and D-C, were found in naturally contaminated samples whatever their animal origin and their geographical location. (biomedsearch.com)
- The development of PCR-based methods for the detection and typing of BoNT-producing clostridia would be an ideal alternative to the mouse bioassay. (asm.org)
- We have identified the 58-kDa protein from rat brain synaptosomes, to which type B neurotoxin (BoNT/B) binds only in the presence of gangliosides GT1b/GD1a. (nii.ac.jp)
- Clostridium botulinum is a taxonomic designation for at least four diverse groups of Gram positive spore-forming anaerobic bacteria that produce the most potent naturally occurring toxin known, botulinum neurotoxin (BoNT). (biomedcentral.com)
- Here, we present a closed genome sequence for Clostridium argentinense strain 89G, the first strain identified to produce botulinum neurotoxin type G (BoNT/G). Although discovered in 1970, to date, there have been no reference quality sequences publicly available for this species. (cdc.gov)
- There is no consensus of the therapeutic efficacy and safety between suburothelial injection and trigonal injection of botulinum toxin A (BoNT-A) in treatment of interstitial cystitis/blad. (bioportfolio.com)
- Group II is a subset of a more diverse clade that includes other saccharolytic clostridia, such as C. acetobutylicum , C. beijerinckii , and toxic and nontoxic Group V C. baratii and Group VI C. butyricum . (biomedcentral.com)
- Clostridium butyricum , the type species of the genus Clostridium , is considered an obligate anaerobe, yet it has been shown to grow in the presence of oxygen. (asm.org)
- To understand the biological mechanisms allowing the adaptation of vegetative cells of C. butyricum type E to oxygen, we compared the proteome and metabolome profiles of the clostridial cultures grown for 5 h under either aerated or anaerobic conditions. (asm.org)
- Isolation of C. botulinum organism devoid of toxin from the suspected food has little significance. (inchem.org)
- Genome sequences can tell us a lot about the biology of the organism, but research into clostridia has been hampered by the lack of a good genetic system. (innovations-report.com)
- As an endospore-forming organism, Clostridium botulinum is somewhat unique. (kenyon.edu)
- Although in the same group as Clostridium difficile - the Cdiff superbug - C. botulinum has a genome that is remarkable because it is so stable," commented Dr Mohammed Sebaihia, lead author on the paper from the Wellcome Trust Sanger Institute. (innovations-report.com)
- This comparative study will be carried out in the hospital microbiology laboratory of a tertiary academic health center, St. Joseph's Healthcare (SJH) affiliated with McMaster University, Hamilton, ON on 500 individual stool samples from patients greater than 12 months of age to determine an efficacy of distinction between current gold standard and other methods of testing for Clostridium difficile. (bioportfolio.com)
- The Clover trial is evaluating an investigational vaccine that may help to prevent Clostridium difficile infection. (bioportfolio.com)
- This clinical study is conducted to assess the safety and immunogenicity of a Clostridium difficile vaccine (CDVAX) in healthy adult volunteers. (bioportfolio.com)
- This study will investigate a Clostridium difficile vaccine in healthy adults aged 65-85 years. (bioportfolio.com)
- IL-27/IL-27receptor signaling provides protection in Clostridium difficile-induced colitis. (bioportfolio.com)
- Clostridium difficile is a leading cause of nosocomial infection. (bioportfolio.com)
- The role of cytokine IL-27 in the immunopathology of Clostridium difficile infection (CDI) remains unknown. (bioportfolio.com)
- Accuracy of Xpert Clostridium difficile assay for the diagnosis of Clostridium difficile infection: A meta analysis. (bioportfolio.com)
- There is an urgent need for rapid and accurate microbiological diagnostic assay for detection of Clostridium difficile infection (CDI). (bioportfolio.com)
- High prevalence of Clostridium difficile PCR ribotype 078 in pigs in Korea. (bioportfolio.com)
- Clostridium difficile can cause neonatal enteritis, but has been isolated from both diseased and healthy pigs. (bioportfolio.com)
- A Surgical Clostridium-Associated Risk of Death Score Predicts Mortality After Colectomy for Clostridium difficile. (bioportfolio.com)
- A Clostridium difficile-associated risk of death score was recently developed and validated by using a national cohort of both nonsurgical and surgical patients admitted with C difficile infection. (bioportfolio.com)
- Whole-genome analysis reveals the evolution and transmission of an MDR DH/NAP11/106 Clostridium difficile clone in a paediatric hospital. (bioportfolio.com)
- Clostridium difficile strain DH/NAP11/106, a relatively antibiotic-susceptible strain, is now the most common cause of C. difficile infection (CDI) among adults in the USA. (bioportfolio.com)
- Enteritis due to Clostridium difficile ( C difficile or C diff ) (008.45) that grows in the large intestine typically occurs after a patient has taken antibiotics for a while. (fortherecordmag.com)
- There are several types of C. botulinum: although described as variants of a single species, they are really very different organisms linked simply because they have the deadly toxin. (innovations-report.com)
- We have developed a highly efficient system, the ClosTron, with which we have, in a few months, knocked out over 30 genes in four different clostridial species, including eight in C. botulinum. (innovations-report.com)
- It belongs to the pathogenic species C. botulinum , but as a genotypic species it should also include C. novyi and C. haemolyticum . (biomedcentral.com)
- Neurotoxin gene profiling of clostridium botulinum types C and D native to different countries within Europe. (biomedsearch.com)
- Effects of Carbon Dioxide on Neurotoxin Gene Expression in Non-proteolytic Clostridium botulinum type E. (lu.se)
- Quantitative reverse transcription-PCR and an enzyme-linked immunosorbent assay were used to quantify expression of the type E botulinum neurotoxin gene (cntE) and formation of type E neurotoxin. (lu.se)
- Differences between the type B neurotoxin gene sequence of Clostridium botulinum type A(B) and Cl. (ovid.com)
- p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene. (uniprot.org)
- The type F6 neurotoxin gene cluster locus of group II clostridium botulinum has evolved by successive disruption of two different ancestral precursors. (cdc.gov)
- Type A is used in botox therapy. (sciencephoto.com)
- Botulinum toxin type A (BOTOX) for treatment of migraine headaches: an open-label study. (springer.com)
- Advise patients who are considering Botox (botulinum toxin type A) injections that they should get treatment only from a licensed and experienced doctor who uses FDA-approved and certified Botox. (medpagetoday.com)
- With more than 1,800 publications on botulinum toxin type A in scientific and medical journals, Botox is one of the most widely researched medicines in the world and has been approved for 20 indications in more than 70 countries. (medpagetoday.com)
- Botulinum Toxin Type A , 150iu , Allergan Most medical professionals recommend that Botox injections are used once every six to nine months in order to achieve optimal results. (ecplaza.net)
- Professor Nigel Minton, Professor of Applied Molecular Microbiology at The University of Nottingham, has developed new methods to knock out genes in clostridia. (innovations-report.com)
Aspects of botulinum toxin1
- Scientific and therapeutic aspects of Botulinum toxin. (springer.com)
- In the present study, the effects of carbon dioxide on growth of, and neurotoxin production by, non-proteolytic Clostridium botulinum type E were studied during the growth cycle. (lu.se)
- The Clostridium botulinum in Group I produce the toxin types A, B, and F. They are proteolytic and have an optimal growth temperature of 37 degrees Celsius but can thrive in temperatures ranging from 12.8-48 degrees Celsius (Peck et al. (kenyon.edu)
- Multilocus sequence typing (MLST) using seven proteolytic C. botulinum housekeeping genes ( http://pubmlst.org/cbotulinum ) revealed that PA 3679 resides in the same clade as the outlier A1 toxin-producing C. botulinum strain A207 ( 3 ). (asm.org)
Neurotoxin that causes1
- Clostridium botulinum secretes a potent neurotoxin that causes devastating effects when ingested, including paralysis and death if not treated. (cdc.gov)
- According to their immunological properties, BoNTs are divided into 7 types (A to G) and each type is generally synthesized by only one strain. (omicsonline.org)
- Validity of botulinum neurotoxin serotype H. [J Infect Dis. (nih.gov)
- Botulinum toxin type A* Quantity corresponding to 125 Speywood units (U)** for one vial. (medicines.org.uk)
- 1 vial of Neuronox® contains 100 units of botulinum . (ecplaza.net)
- Package 100 Units/Vial , Package with Ice Pack Description It appears as a lyophilized white powder for injection in a colorless transparent vial Composition Active ingredient : Clostridium botulinum toxin type A Isotonic agent : Sodium chloride. (ecplaza.net)
- You should not receive Dysport injecton if you are allergic to botulinum toxin or if you have an infection, swelling, or muscle weakness in the area where the medicine will be injected. (oddwayinternational.com)
- The lack of a complete type A(B) strain representative genome sequence hinders the ability to assemble genomes by reference mapping and analysis of SNPs at pre-identified sites. (beds.ac.uk)
- The genome sequence shows that C. botulinum doesn't have subtle tools to evade our human defences or tricky methods of acquiring resistance to antibiotics. (innovations-report.com)
- This has been reported in patients who have been treated with intramuscular injections of botulinum toxin. (inchem.org)
- In 2010, the FDA approved intramuscular botulinum toxin injections for prophylactic treatment of chronic migraine headache . (wikipedia.org)
- Intramuscular injection of botulinum toxin for the treatment of wrist and finger spasticity after a stroke. (springer.com)
- Group IV produces toxin type G. The genome for the group I bacteria has been fully sequenced revealing that this bacteria contains chromosomal DNA and a bacteriocin-encoding plasmid (Figure 2). (kenyon.edu)
- In the presence of low oxygen levels and favorable temperatures, C. botulinum produces the botulinum toxin. (news-medical.net)
- The objective of this study was to develop a rapid and robust real-time PCR method for detecting C. botulinum type A. Four different techniques for the extraction and purification of DNA from cultured samples were initially compared. (asm.org)
- Terajima J., B. Syuto and S. Kubo: Purification and characterization of neurotoxin produced by Clostridium botulinum type C 6813. (ac.ke)
- The purification and crystallization of Clostridium botulinum type A toxin. (springer.com)
- Research suggests that EGS is a toxico-infection involving Clostridium botulinum (C. botulinum), with several studies demonstrating a protective effect of natural immunity to C. botulinum type C. Other clostridial diseases are successfully prevented by vaccination, implying that it should be possible to prevent EGS by vaccination. (animalwelfarefoundation.org.uk)
- This study reports on the development of low-density macroarrays based on the GeneDisc cycler platform (Pall-GeneDisc Technologies) applied to the simultaneous detection of the C. botulinum subtypes C, C-D, D, and D-C. The limit of detection of the PCR assays was 38 fg of total DNA, corresponding to 15 genome copies. (biomedsearch.com)
- Standard microbiological methods take into consideration only the detection of C. botulinum . (asm.org)
- The detection limit of the reaction was less than 6 × 10 1 copies of C. botulinum type A DNA. (asm.org)
- Detection of Clostridium botulinum toxin associated with food samples will be referred to CDC in Atlanta. (wyo.gov)
- Interleukin 2 secretion by T cells for detection of biologically active Staphylococcal enterotoxin type E. Journal of Food Protection. (usda.gov)
- A serum specimen obtained from the patient on October 4 was positive for type A botulinal toxin by mouse bioassay. (cdc.gov)
- these events, in addition to recombination among the toxin complex genes, have led to the lineages observed today within the neurotoxin-producing clostridia. (biomedcentral.com)
- Unlike Cdiff, in which more than 10 per cent of genes have been acquired from other bacteria, there is almost no footprint of these in C. botulinum. (innovations-report.com)
- Professor Mike Peck, from the Institute of Food Research, commented that "It is astonishing that 43 per cent of the predicted genes in the C. botulinum genome are absent from the other five sequenced clostridia, and only 16 per cent of the C. botulinum genes are common to all five. (innovations-report.com)
- The neurotoxin genes of C. botulinum type C and D are carried by bacteriophages, which express unstable lysogeny and are frequently lost during cultivation. (biomedcentral.com)
Injections of botulinum1
- Clinical outcomes of intravesical injections of botulinum toxin type A in patients with refractory idiopathic overactive bladder. (bioportfolio.com)
- only types A, B, E and F cause illness in humans. (empowher.com)
- Botulinum Neurotoxin Type A Complex from Clostridium botulinum (Terms 1, 3, 7 & 8) (128A) is a high quality bacterial toxin for research. (quadratech.co.uk)
- Meditoxin (Botulinux A toxin ) 100 units is a botulinum toxin type A complex (100 Units) pharmaceutical manufactured by Medy-Tox Inc. and officially launched in Korea since 2006. (ecplaza.net)
- Neuronox® is a Botulinum toxin type A complex purified from Clostridium botulinum , manufactured by Medy-Tox® in Korea. (ecplaza.net)
- The largest difference between C. botulinum group III isolates occurred within their surprisingly large plasmidomes and in the pattern of mobile elements insertions. (biomedcentral.com)
- Botulinum toxin causes flaccid paralysis by inhibiting neurotransmitter (acetylcholine) release from the presynaptic membranes of nerve terminals of the eukaryotic host skeletal and autonomic nervous system, with frequent heart or respiratory failure. (uniprot.org)
- Botulinum is the most acutely lethal toxin known, with an estimated human median lethal dose (LD 50 ) of 1.3-2.1 ng /kg intravenously or intramuscularly and 10-13 ng/kg when inhaled. (wikipedia.org)
- There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. (jcvi.org)