A water-soluble benzodiazepine derivative effective in the treatment of anxiety. It has also muscle relaxant and anticonvulsant actions.
An intermediate in the metabolism of DIAZEPAM to OXAZEPAM. It may have actions similar to those of diazepam.
Agents that alleviate ANXIETY, tension, and ANXIETY DISORDERS, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. ADRENERGIC BETA-ANTAGONISTS are commonly used in the symptomatic treatment of anxiety but are not included here.
A group of mental disorders associated with organic brain damage and caused by poisoning from alcohol.

S-16924 [(R)-2-[1-[2-(2,3-dihydro-benzo[1,4]dioxin-5-yloxy)-ethyl]- pyrrolidin-3yl]-1-(4-fluorophenyl)-ethanone], a novel, potential antipsychotic with marked serotonin1A agonist properties: III. Anxiolytic actions in comparison with clozapine and haloperidol. (1/16)

S-16924 is a potential antipsychotic that displays agonist and antagonist properties at serotonin (5-HT)1A and 5-HT2A/2C receptors, respectively. In a pigeon conflict procedure, the benzodiazepine clorazepate (CLZ) increased punished responses, an action mimicked by S-16924, whereas the atypical antipsychotic clozapine and the neuroleptic haloperidol were inactive. Similarly, in a Vogel conflict paradigm in rats, CLZ increased punished responses, an action shared by S-16924 but not by clozapine or haloperidol. This action of S-16924 was abolished by the 5-HT1A antagonist WAY-100,635. Ultrasonic vocalizations in rats were inhibited by CLZ, S-16924, clozapine, and haloperidol. However, although WAY-100,635 abolished the action of S-16924, it did not affect clozapine and haloperidol. In a rat elevated plus-maze, CLZ, but not S-16924, clozapine, and haloperidol, increased open-arm entries. Like CLZ, S-16924 increased social interaction in rats, whereas clozapine and haloperidol were inactive. WAY-100,635 abolished this action of S-16924. CLZ, S-16924, clozapine, and haloperidol decreased aggressive interactions in isolated mice, but this effect of S-16924 was not blocked by WAY-100, 635. All drugs inhibited motor behavior, but the separation to anxiolytic doses was more pronounced for S-16924 than for CLZ. Finally, in freely moving rats, CLZ and S-16924, but not clozapine and haloperidol, decreased dialysis levels of 5-HT in the nucleus accumbens: this action of S-16924 was blocked by WAY-100,165. In conclusion, in contrast to haloperidol and clozapine, S-16924 possessed a broad-based profile of anxiolytic activity at doses lower than those provoking motor disruption. Its principal mechanism of action was activation of 5-HT1A (auto)receptors.  (+info)

Use of micellar mobile phases for the chromatographic determination of clorazepate, diazepam, and diltiazem in pharmaceuticals. (2/16)

An ODS-2 column, a micellar mobile phase of high elution strength containing 0.1M sodium dodecyl sulfate and 3% (v/v) butanol, and ultraviolet detection at 230 nm are used for the determination of either of two benzodiazepines (clorazepate and diazepam) and a benzothiazepine (diltiazem) in pharmaceuticals. The procedure is shown to be competitive against conventional chromatography with methanol-water mobile phases, especially for diltiazem. The composition of the micellar mobile phase is selected using a predictive strategy based on an accurate retention model and assisted by computer simulation. Calibration graphs are linear at least in the 2.5 to 20 microg/mL, 4 to 20 microg/mL, and 5 to 40 microg/mL ranges for clorazepate, diazepam, and diltiazem, respectively. The intra- and interday repeatabilities (%) are clorazepate (1.7, 5.2), diazepam (0.43, 3.7), and diltiazem (0.36, 3.1). Limits of detection are well below the concentrations of the drugs found in the commercial pharmaceutical preparations analyzed. The drug contents evaluated with the proposed procedure are compared with the declared contents given by the manufacturers. The achieved percentages of label claim are usually between 95 and 104%.  (+info)

Flumazenil-sensitive dose-related physical dependence in planarians produced by two benzodiazepine and one non-benzodiazepine benzodiazepine-receptor agonists. (3/16)

Two benzodiazepine (midazolam and clorazepate) and one non-benzodiazepine (zolpidem) benzodiazepine-receptor agonists produced dose-related physical dependence, as evidenced by abstinence-induced decrease in planarian locomotor velocity (pLMV) when drug-exposed planarians were placed into drug-free water, but not when they were placed into drug-containing water (i.e., an abstinence-induced withdrawal, since the effect was only obtained in the removal of drug and not in the continued presence of drug). We have previously shown that the decrease in pLMV is associated with specific and transient withdrawal signs. In the present study, the selective benzodiazepine-receptor antagonist flumazenil significantly antagonized (P<0.05), by co-application, the ability of each agonist to produce the withdrawal. These results: (1) suggest that benzodiazepine-receptor agonists, for two different chemical categories, produce dose-related physical dependence manifested as abstinence-induced withdrawal in this simple and convenient model, and (2) in the absence of cloning or radioligand binding literature, suggest a possible specific interaction site (receptor?) for these compounds in planarians.  (+info)

Generalized skin drug eruption to natalizumab in a patient with multiple sclerosis. (4/16)

We report a generalized skin eruption in a young man being treated with natalizumab, a new drug used in patients with multiple sclerosis.  (+info)

Differential behavioral profile induced by the injection of dipotassium chlorazepate within brain areas that project to the nucleus accumbens septi. (5/16)

BACKGROUND: The effect of the agonism on gamma-aminobutyric acid (GABA) receptors was studied within medial prefrontal cortex (mPFC), amygdala (AMY) and ventral hipocampus (VH) in the plus-maze test in male rats bilaterally cannulated. These structures send glutamatergic projections to the nucleus accumbens septi (NAS), in which interaction and integration between these afferent pathways has been described. In a previous study of our group, blockade of glutamatergic transmission within NAS induced an anxiolytic like effect. METHODS: Three rat groups received either saline or dipotassium chlorazepate (1 or 2 mug/1 mul solution) 15 min before testing. Time spent in the open arms (TSOA), time per entry (TPE), extreme arrivals (EA), open and closed arms entries (OAE, CAE) and relationship between open- and closed-arms quotient (OCAQ) were recorded. RESULTS: In the AMY injected group TSOA, OAE and EA were increased by the higher doses of dipotassium chlorazepate (p < 0.01). In the mPFC, TPE was decreased by both doses (p < 0.05). Injection within ventral hippocampus (VH) decreased TSOA, OAE and OCAQ with lower doses (p < 0.05). When the three studied saline groups were compared, TSOA, OAE, EA and OCAQ were enhanced in the VH group when compared to mPFC and AMY (p < 0.001). Insertion of inner canula (p < 0.001, p < 0.01, p < 0.01) and saline injection showed an increasing significant difference (p < 0.001 in all cases) with the action of guide cannula alone within VH in TSOA, OAE and EA. CONCLUSION: We conclude that the injection of dipotassium chlorazepate has a differential effect depending of the brain area, leading to facilitatory and inhibitory effects on anxiety processing.  (+info)

Allosteric modulation by benzodiazepine receptor ligands of the GABAA receptor channel expressed in Xenopus oocytes. (6/16)

Chick brain mRNA was isolated and injected into Xenopus oocytes. This led to the expression in the surface membrane of functional GABA-activated channels with properties reminiscent of vertebrate GABAA channels. The GABA-induced current was analyzed quantitatively under voltage-clamp conditions. Picrotoxin inhibited this current in a concentration-dependent manner with IC50 = 0.6 microM. The allosteric modulation of GABA currents by a number of drugs acting at the benzodiazepine binding site was characterized quantitatively. In the presence of the benzodiazepine receptor ligands diazepam and clorazepate, GABA responses were enhanced, and in the presence of the convulsant beta-carboline compound methyl 6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate (DMCM), they were depressed. Maximal stimulation of the response elicited by 10 microM GABA was 160% with diazepam and 90% with clorazepate, and maximal inhibition was 42% with DMCM, 30% with methyl beta-carboline-3-carboxylate (beta-CCM), 15% with ethyl-8-fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo [1,5a][1,4]benzodiazepine-3-carboxylate (Ro 15-1788), and 12% with ethyl beta-carboline-3-carboxylate (beta-CCE). Half-maximal stimulation was observed with 20 nM diazepam and 390 nM clorazepate, respectively, and half-maximal inhibition with 6 nM DMCM. beta-CCM had a similar effect to DMCM, whereas beta-CCE and Ro 15-1788 showed only small inhibition at low concentrations (less than 1 microM). All the tested carboline compounds and Ro 15-1788 showed a biphasic action and stimulated GABA current at concentrations higher than 1 microM.(ABSTRACT TRUNCATED AT 250 WORDS)  (+info)

Clorazepate use may prevent alcohol withdrawal convulsions. (7/16)

Clorazepate dipotassium was administered orally for the five-day prophylactic treatment of potential, incipient and overt withdrawal signs and symptoms in 226 patients on admission to an inpatient alcohol treatment unit. Conservative estimates based on these patients' histories and on literature reports predicted that between 7 and 40 (3% to 18%) of these persons would be expected to have a withdrawal convulsion. No patients experienced convulsions. This complete absence of seizures suggests that clorazepate is effective in counteracting convulsive and other manifestations of the alcohol withdrawal syndrome.  (+info)

Single daily dose treatment of anxiety with clobazam or dipotassium clorazepate. (8/16)

1 Forty-four clinically anxious patients entered a comparative double-blind trial of clobazam 20 mg, clobazam 30 mg and dipotassium clorazepate 15 mg, all drugs given as a single dose at night. 2 Assessment by the Hamilton Anxiety Scale, Morbid Anxiety Inventory (Salkind) and a Visual Analogue Scale showed a statistically significant improvement for all treatment groups after 2 weeks, with continued improvement after a further 2 weeks. 3 Daytime drowsiness was the commonest side-effect in all treatment groups but there was a tendency for a lower incidence in patients on clobazam. There was no evidence of a dose-related incidence of drowsiness in the clobazam 20 mg and 30 mg groups. Other side-effects were few and nonspecific. 4 Clobazam is a 1,5-benzodiazepine with an elimination half-life of 18 hours. When given in single doses of 20-30 mg at night it has an equivalent effect to dipotassium clorazepate 15 mg.  (+info)

Types of Alcoholic Psychoses:

1. Alcohol-related psychosis (ARP): This type of psychosis can occur in people who are intoxicated or experiencing withdrawal symptoms after stopping alcohol use. Symptoms include hallucinations, delusions, and disorganized thinking and behavior.
2. Korsakoff's syndrome: This is a memory disorder that occurs as a result of vitamin B1 (thiamine) deficiency caused by heavy drinking. People with Korsakoff's syndrome may experience confusion, amnesia, and psychotic symptoms such as hallucinations and delusions.
3. Wernicke-Korsakoff syndrome: This is a disorder that affects the brain and nervous system, caused by a combination of thiamine deficiency and chronic alcohol consumption. Symptoms include confusion, memory loss, and psychotic symptoms such as hallucinations and delusions.

Causes and Risk Factors:

1. Alcohol use: The primary cause of alcoholic psychosis is excessive and long-term alcohol consumption.
2. Genetics: People with a family history of mental health issues may be more susceptible to developing alcoholic psychosis.
3. Nutritional deficiencies: Poor nutrition, especially a lack of vitamin B1 (thiamine), can contribute to the development of alcoholic psychosis.
4. Brain changes: Long-term heavy drinking can cause changes in brain structure and function, which may increase the risk of developing psychotic symptoms.
5. Other factors: Trauma, stress, and social isolation may also contribute to the development of alcoholic psychosis.

Symptoms:

1. Hallucinations: People with alcoholic psychosis may experience hallucinations that can be visual, auditory, or both. These can range from simple sounds or voices to complex visions or conversations.
2. Delusions: Delusions are false beliefs that are not based in reality and cannot be explained by a person's cultural or religious beliefs. In alcoholic psychosis, delusions can range from paranoid thoughts to grandiose ideas.
3. Confusion: People with alcoholic psychosis may experience confusion about their surroundings, events, or people in their lives.
4. Memory loss: Alcoholic psychosis can cause short-term memory loss, difficulty with concentration, and difficulty learning new information.
5. Psychomotor agitation: People with alcoholic psychosis may exhibit agitated behavior, such as pacing, restlessness, or irritability.
6. Catatonia: In severe cases of alcoholic psychosis, people may exhibit catatonic symptoms, such as immobility, mutism, or negativism (resisting instructions or commands).

Diagnosis:

1. Physical examination: A healthcare professional will perform a physical examination to rule out other medical conditions that may cause similar symptoms.
2. Medical history: The healthcare professional will ask questions about the person's medical history, including their alcohol use and any previous psychotic episodes.
3. Mental status evaluation: The healthcare professional will evaluate the person's mental status, including their cognitive function, memory, and thought processes.
4. Laboratory tests: The healthcare professional may order laboratory tests to rule out other medical conditions that may cause similar symptoms.
5. Imaging studies: The healthcare professional may order imaging studies, such as a CT or MRI scan, to rule out other medical conditions that may cause similar symptoms.

Treatment:

1. Hospitalization: People with alcoholic psychosis are often hospitalized for their own safety and the safety of others.
2. Detoxification: The person will undergo detoxification to remove alcohol from their body.
3. Antipsychotic medications: The healthcare professional may prescribe antipsychotic medications to reduce the severity of symptoms.
4. Antidepressant medications: The healthcare professional may prescribe antidepressant medications to help manage depressive symptoms.
5. Counseling and therapy: The person will receive counseling and therapy to address their alcohol use disorder and any co-occurring mental health conditions.
6. Family support: The healthcare professional may involve the person's family in their treatment, as they can provide valuable support and help with recovery.
7. Follow-up care: The healthcare professional will follow up with the person to monitor their progress and make any necessary adjustments to their treatment plan.

Prognosis:
The prognosis for alcoholic psychosis is generally good if the person receives prompt and appropriate treatment. However, the condition can be challenging to treat, and recovery may take time. It is essential for the person to stay in treatment and follow their healthcare professional's recommendations to achieve the best possible outcome.

Complications:
Alcoholic psychosis can have several complications, including:

1. Suicide: People with alcoholic psychosis are at a higher risk of suicide due to their underlying mental health conditions and the stress of dealing with the condition.
2. Seizures: Alcohol withdrawal seizures can occur in people who suddenly stop drinking alcohol.
3. Dementia: Chronic alcohol consumption can cause permanent damage to the brain, leading to dementia.
4. Liver disease: Long-term heavy drinking can lead to liver disease, which can be life-threatening.
5. Heart disease: Excessive alcohol consumption can increase the risk of heart disease and stroke.
6. Nutritional deficiencies: Alcohol can interfere with the body's ability to absorb nutrients, leading to deficiencies in vitamins and minerals.
7. Social problems: Alcoholic psychosis can cause significant social problems, including strained relationships, financial difficulties, and legal issues.

Prevention:
Preventing alcoholic psychosis is essential, as it can be challenging to treat once it has developed. Some ways to prevent the condition include:

1. Avoiding excessive alcohol consumption: Limiting alcohol intake to moderate levels (up to one drink per day for women and up to two drinks per day for men) can reduce the risk of developing alcoholic psychosis.
2. Seeking professional help: If you or someone you know is struggling with alcohol addiction, seeking professional help from a mental health professional or a substance abuse treatment center can be beneficial.
3. Maintaining a healthy lifestyle: Engaging in regular exercise, eating a balanced diet, and getting enough sleep can help reduce the risk of developing alcoholic psychosis.
4. Avoiding triggers: Identifying and avoiding triggers that may cause you to drink excessively can help prevent the development of alcoholic psychosis.
5. Support groups: Joining a support group, such as Alcoholics Anonymous (AA), can provide a supportive community and resources for individuals struggling with alcohol addiction.

Treatment:
If you or someone you know is experiencing symptoms of alcoholic psychosis, it is essential to seek professional help immediately. Treatment options may include:

1. Hospitalization: In severe cases of alcoholic psychosis, hospitalization may be necessary to ensure the individual's safety and provide appropriate care.
2. Medications: Antipsychotic medications, such as risperidone or olanzapine, may be prescribed to manage symptoms of alcoholic psychosis.
3. Therapy: Cognitive-behavioral therapy (CBT) and other forms of talk therapy can help individuals understand the underlying causes of their addiction and develop strategies for maintaining sobriety.
4. Support groups: Joining a support group, such as Alcoholics Anonymous (AA), can provide a supportive community and resources for individuals recovering from alcoholic psychosis.
5. Lifestyle changes: Making lifestyle changes, such as avoiding triggers, engaging in regular exercise, and maintaining a healthy diet, can help individuals recovering from alcoholic psychosis maintain their sobriety and reduce the risk of relapse.

... is used in the form of a dipotassium salt. It is unusual among benzodiazepines in that it is freely soluble in ... Clorazepate is a long-acting benzodiazepine drug. Clorazepate produces the active metabolite desmethyl-diazepam, which is a ... Clorazepate, like other benzodiazepines, is widely distributed and is highly bound to plasma proteins; clorazepate also crosses ... Ther., 4, 239 (1969) Rx-List.com - Clorazepate Inchem.org - Clorazepate (All articles with dead external links, Articles with ...
Diazepam and Clorazepate Dipotassium have been used successfully to alleviate cramping in some cases, but have also failed to ...
... continued tapering of dose with an oral long-acting benzodiazepine such as clorazepate dipotassium. When signs of tolerance to ...
... clorazepate dipotassium MeSH D03.438.079.080.250 - estazolam MeSH D03.438.079.080.550 - medazepam MeSH D03.438.079.080.575 - ...
... dipotassium clorazepate (INN) diprafenone (INN) dipraglurant (INN) diprenorphine (INN) Diprivan diprobutine (INN) diprofene ( ...
The 2014 Ju-Jitsu World Championship were the 12th edition of the Ju-Jitsu World Championships, and were held in Paris, France from November 28 to November 30, 2014. 28.11.2014 - Men's and Women's Fighting System, Men's and Women's Jiu-Jitsu (ne-waza), Men's Duo System - Classic 29.11.2014 - Men's and Women's Fighting System, Men's and Women's Jiu-Jitsu (ne-waza), Women's Duo System - Classic 30.11.2014 - Men's Jiu-Jitsu (ne-waza), Mixed Duo System - Classic, Team event Vincent MATCZAK (2014-09-30). "4TH INVITAION TO WORLD CHAMPIONSHIP 2014" (PDF). Retrieved 2019-11-28.[dead link] Online results Official results (PDF) Mixed team event results (PDF) (All articles with dead external links, Articles with dead external links from April 2022, Ju-Jitsu World Championships, 2014 in French sport ...
Bolley L. "Bo" Johnson (born November 15, 1951) is an American politician from the state of Florida. A member of the Democratic Party, Johnson was a member of the Florida House of Representatives, and served as the Speaker of the Florida House of Representatives. Johnson is from Milton, Florida. His father and grandfather served as county commissioners for Santa Rosa County, Florida. Johnson graduated from Milton High School, and became the first member of his family to attend college. He received his bachelor's degree from Florida State University. Johnson volunteered for Mallory Horne when Horne served as the president of the Florida Senate. At the age of 22, Johnson met Lawton Chiles, then a member of the United States Senate, who hired him as a legislative aide in 1973. Johnson was elected to the Florida House of Representatives, representing the 4th district from November 7, 1978 to November 3, 1992. He also served the 1st district from November 3, 1992 to November 8, 1994. He became the ...
... may refer to: Don't Say No (Billy Squier album), a 1981 album by American rock singer Billy Squier, and its title track Don't Say No (Seohyun EP), a 2016 extended play by South Korean pop singer Seohyun, and its title track "Don't Say No" (Tom Tom Club song), from the 1988 album Boom Boom Chi Boom Boom "Don't Say No", by Robbie Williams from the 2005 album Intensive Care "Don't Say No Tonight", a 1985 single by Eugene Wilde This disambiguation page lists articles associated with the title Don't Say No. If an internal link led you here, you may wish to change the link to point directly to the intended article. (Disambiguation pages with short descriptions, Short description is different from Wikidata, All article disambiguation pages, All disambiguation pages, Disambiguation pages ...
The Dewoitine 37 was the first of a family of 1930s French-built monoplane fighter aircraft. The D.37 was a single-seat aircraft of conventional configuration. Its fixed landing gear used a tailskid. The open cockpit was located slightly aft of the parasol wing. The radial engine allowed for a comparatively wide fuselage and cockpit. Design of this machine was by SAF-Avions Dewoitine but owing to over work at that companies plant at the time, manufacture of the D.37/01 was transferred to Lioré et Olivier. They were high-wing monoplanes of all-metal construction with valve head blisters on their engine cowlings. The first prototype flew in October 1931. Flight testing resulted in the need for multiple revisions in both engine and airframe, so it was February 1934 before the second prototype flew. Its performance prompted the French government to order for 28 for the Armée de l'Air and Aéronavale. The Lithuanian government ordered 14 that remained in service with their Air Force until 1936, ...
The Noor-ul-Ain (Persian: نور العين, lit. 'the light of the eye') is one of the largest pink diamonds in the world, and the centre piece of the tiara of the same name. The diamond is believed to have been recovered from the mines of Golconda, Hyderabad in India. It was first in possession with the nizam Abul Hasan Qutb Shah, later it was given as a peace offering to the Mughal emperor Aurangazeb when he defeated him in a siege. It was brought into the Iranian Imperial collection after the Persian king Nader Shah Afshar looted Delhi in the 18th century.[citation needed] The Noor-ul-Ain is believed to have once formed part of an even larger gem called the Great Table diamond. That larger diamond is thought to have been cut in two, with one section becoming the Noor-ul-Ain and the other the Daria-i-Noor diamond. Both of these pieces are currently part of the Iranian Crown Jewels. The Noor-ul-Ain is the principal diamond mounted in a tiara of the same name made for Iranian Empress Farah ...
The Benoist Land Tractor Type XII was one of the first enclosed cockpit, tractor configuration aircraft built. Benoist used "Model XII" to several aircraft that shared the same basic engine and wing design, but differed in fuselage and control surfaces. The Type XII was a tractor-engined conversion of the model XII headless pusher aircraft that resembled the Curtiss pusher aircraft. Demonstration pilots used Benoist aircraft to demonstrate the first parachute jumps, and the tractor configuration was considered much more suitable for the task. The first example named the "Military Plane" had a small box frame covered fuselage that left the occupants mostly exposed to the wind. The later model XII "Cross Country Plane" had a full fuselage that occupants sat inside of. The first tractor biplane used a wooden fuselage with a small seat on top. The wings were covered with a Goodyear rubberized cloth. The first model XII was built in the spring of 1912. On 1 March 1912, Albert Berry used a headless ...
... (also known as Yalmotx in Qʼanjobʼal) is a town, with a population of 17,166 (2018 census), and a municipality in the Guatemalan department of Huehuetenango. It is situated at 1450 metres above sea level. It covers a terrain of 1,174 km². The annual festival is April 29-May 4. Barillas has a tropical rainforest climate (Af) with heavy to very heavy rainfall year-round and extremely heavy rainfall from June to August. Citypopulation.de Population of departments and municipalities in Guatemala Citypopulation.de Population of cities & towns in Guatemala "Climate: Barillas". Climate-Data.org. Retrieved July 26, 2020. Muni in Spanish Website of Santa Cruz Barillas Coordinates: 15°48′05″N 91°18′45″W / 15.8014°N 91.3125°W / 15.8014; -91.3125 v t e (Articles with short description, Short description is different from Wikidata, Pages using infobox settlement with no coordinates, Articles containing Q'anjob'al-language text, Coordinates on Wikidata, ...
Maria Margaret La Primaudaye Pollen (10 April 1838 - c. 1919), known as Minnie, was a decorative arts collector. As Mrs John Hungerford Pollen, she became known during the early-twentieth century as an authority on the history of textiles, publishing Seven Centuries of Lace in 1908. Maria Margaret La Primaudaye was born into a Huguenot family on 10 April 1838, the third child of the Revd Charles John La Primaudaye, a descendant of Pierre de La Primaudaye. She was educated in Italy. Her family converted to Catholicism in 1851, and it was in Rome that her father met another recent English convert, John Hungerford Pollen, previously an Anglican priest and a decorative artist. She became engaged to Pollen, who was then seventeen years her senior, in the summer of 1854, and was married in the church of Woodchester monastery, near Stroud, Gloucester, on 18 September 1855. The Pollens initially settled in Dublin, where John Hungerford Pollen had been offered the professorship of fine arts at the ...
Ronald Robert Fogleman (born January 27, 1942) is a retired United States Air Force general who served as the 15th Chief of Staff of the Air Force from 1994 to 1997 and as Commanding General of the United States Transportation Command from 1992 to 1994. A 1963 graduate from the United States Air Force Academy, he holds a master's degree in military history and political science from Duke University. A command pilot and a parachutist, he amassed more than 6,800 flying hours in fighter, transport, tanker and rotary wing aircraft. He flew 315 combat missions and logged 806 hours of combat flying in fighter aircraft. Eighty of his missions during the Vietnam War were as a "Misty FAC" in the F-100F Super Sabre at Phù Cát Air Base, South Vietnam between 25 December 1968 and 23 April 1969. Fogleman was shot down in Vietnam in 1968, while piloting an F-100. He was rescued by clinging to an AH-1 Cobra attack helicopter that landed at the crash site. In early assignments he instructed student pilots, ...
Peachtree Street" is a 1950 song co-written and recorded by Frank Sinatra in a duet with Rosemary Clooney. The song was released as a Columbia Records single. Frank Sinatra co-wrote the song with Leni Mason and Jimmy Saunders. Mason composed the music while Sinatra and Saunders wrote the lyrics. The song was arranged by George Siravo The song was released as an A side Columbia 10" 78 single, Catalog Number 38853, Matrix Number CO-43100-1 and as a 7" 33, 1-669. The B side was the re-issued "This Is the Night." Neither of the songs charted. The subject of the song is a stroll down the street in Atlanta, Georgia of the same name. Sinatra originally intended Dinah Shore to sing the duet with him. When Shore declined, Clooney was asked. The song was recorded on April 8, 1950. The song features spoken asides by Sinatra and Clooney. Rosemary Clooney asks: "Say, Frank, you wanna take a walk?" Frank Sinatra replies: "Sure, sweetie, just pick a street." He noted how there were no peach trees on the ...
... is a painting by American illustrator Norman Rockwell that depicts a Boy Scout in full uniform standing in front of a waving American flag. It was originally created by Rockwell in 1942 for the 1944 Brown & Bigelow Boy Scout Calendar. The model, Bob Hamilton, won a contest to be in the painting and personally delivered a print to the Vice President of the United States at the time, Henry A. Wallace. The painting was created to encourage Scouts to participate in the war effort during World War II. The name of the painting, We, Too, Have a Job to Do, comes from a slogan that the Boy Scouts of America used in 1942 to rally scouts to support the troops by collecting metal and planting victory gardens. The model, Bob Hamilton, won a contest with his local council in Albany, New York, to be depicted in the painting. He traveled to Rockwell's studio in Arlington, Vermont, to model for Rockwell. Since Hamilton was a scout, the uniform shown in the painting was his, unlike some ...
At least 33[failed verification] people were killed by a fuel tanker explosion in Tleil, Akkar District, Lebanon on 15 August 2021. The disaster was reportedly exacerbated by the ongoing Lebanese liquidity crisis; in which the Lebanese pound has plummeted and fuel has been in short supply. The survivors were evacuated by the Lebanese Red Cross. An investigation is underway. The fuel tanker had been confiscated by the Lebanese Armed Forces from black marketeers, the fuel was then distributed/taken by the locals. The son of the man whose land the fuel tanker was located on, was later arrested, accused of deliberately causing the explosion. Agencies (2021-08-15). "At least 20 killed and 79 injured in fuel tank explosion in Lebanon". the Guardian. Retrieved 2021-08-15. "Lebanon fuel explosion kills 22 and injures dozens more". The Independent. 2021-08-15. Archived from the original on 2021-08-15. Retrieved 2021-08-15. "Lebanon: At least 20 dead and dozens injured after fuel tank explodes as ...
The Straubing Tigers are a professional men's ice hockey team, based in Straubing, Germany, that competes in the Deutsche Eishockey Liga. Straubing plays its home games at the Eisstadion am Pulverturm, which has a capacity of 5,800 spectators. Promoted to the DEL in 2006, and operating with one of the league's smallest budgets, the team could finish no better than twelfth before the 2011-12 DEL season, when it reached the semi-finals of the playoffs. Their greatest success so far is the qualification for the season 2020-21 of the Champions Hockey League. In 1941, the then 14-year-old Max Pielmaier and his friends Max Pellkofer and Harry Poiger founded the first hockey team in Straubing. The first official game took place on the first of February 1942 in Hof and was lost by a score of 0:1. In the following year there were several games against other Bavarian teams. The game against Landshut on 31 January. 1943 was the last game during the second World War, because the young players also had to ...
Leina is a village in Saaremaa Parish, Saare County in western Estonia. Before the administrative reform in 2017, the village was in Pihtla Parish. "Lisa. Asustusüksuste nimistu" (PDF). haldusreform.fin.ee (in Estonian). Rahandusministeerium. Retrieved 5 December 2017. "Saaremaa külad endiste valdade piires". www.saaremaa.ee (in Estonian). Archived from the original on 3 December 2017. Retrieved 5 December 2017. Coordinates: 58°17′10″N 22°46′26″E / 58.28611°N 22.77389°E / 58.28611; 22.77389 v t e (CS1 Estonian-language sources (et), Articles with short description, Short description is different from Wikidata, Pages using infobox settlement with no map, Pages using infobox settlement with no coordinates, Saaremaa Parish, Coordinates on Wikidata, Villages in Saare County, All stub articles, Saare County geography stubs ...
A sestiere (plural: sestieri) is a subdivision of certain Italian towns and cities. The word is from sesto ('sixth'), so it is thus used only for towns divided into six districts. The best-known example is the sestieri of Venice, but Ascoli Piceno, Genoa, Milan and Rapallo, for example, were also divided into sestieri. The medieval Lordship of Negroponte, on the island of Euboea, was also at times divided into six districts, each with a separate ruler, through the arbitration of Venice, which were known as sestieri. The island of Crete, a Venetian colony (the "Kingdom of Candia") from the Fourth Crusade, was also divided into six parts, named after the sestieri of Venice herself, while the capital Candia retained the status of a comune of Venice. The island of Burano north of Venice is also subdivided into sestieri. A variation of the word is occasionally found: the comune of Leonessa, for example, is divided into sesti or sixths. Other Italian towns with fewer than six official districts are ...
The Island Image is a Chesapeake Bay log canoe, built in 1885 at Elliot's Island, Maryland, by Herman Jones and Isaac Moore. She is 29'-8½" long with a beam of 5-10¼", and has a straight, raking stem and a sharp stern. It is privately owned, and races under No. 17. She one of the last 22 surviving traditional Chesapeake Bay racing log canoes that carry on a tradition of racing on the Eastern Shore of Maryland that has existed since the 1840s. She is located at Chestertown, Kent County, Maryland. She was listed on the National Register of Historic Places in 1985. "National Register Information System". National Register of Historic Places. National Park Service. April 15, 2008. "Maryland Historical Trust". ISLAND IMAGE (log canoe). Maryland Historical Trust. 2008-06-14. "Island Image #17 , CBLCSA". Island Image. Chesapeake Bay Log Sailing Canoe Association. 2010-07-24. Archived from the original on 2011-07-08. Retrieved 2010-07-29. ISLAND IMAGE (log canoe), Kent County, including photo in 1984, ...
... (Persian: دهستان بردخون) is a rural district (dehestan) in the Bord Khun District of Deyr County, Bushehr Province, Iran. At the 2006 census, its population was 1,115, in 234 families. The rural district has 14 villages. "Census of the Islamic Republic of Iran, 1385 (2006)" (Excel). Statistical Center of Iran. Archived from the original on 2011-11-11. Coordinates: 27°58′N 51°32′E / 27.967°N 51.533°E / 27.967; 51.533 v t e (Articles with short description, Short description matches Wikidata, Pages using infobox settlement with no map, Pages using infobox settlement with no coordinates, Articles containing Persian-language text, Coordinates on Wikidata, Rural Districts of Bushehr Province, Deyr County, All stub articles, Deyr County geography stubs ...
... is a disease of camels caused by the camelpox virus (CMPV) of the family Poxviridae, subfamily Chordopoxvirinae, and the genus Orthopoxvirus. It causes skin lesions and a generalized infection. Approximately 25% of young camels that become infected will die from the disease, while infection in older camels is generally more mild. Although rare, the infection may spread to the hands of those that work closely with camels. The camelpox virus that causes camelpox is an orthopoxvirus that is very closely related to the variola virus that causes smallpox. It is a large, brick-shaped, enveloped virus that ranges in size from 265-295 nm. The viral genetic material is contained in a linear double-stranded DNA consisting of 202,182 tightly packed base pairs. The DNA is encased in the viral core. Two lateral bodies are found outside the viral core, and are believed to hold the enzymes required for viral reproduction. The camelpox virus most often affects members of family Camelidae. However, ...
... s (/ˈfɛzənt/ FEH-zənt) are birds of several genera within the family Phasianidae in the order Galliformes. Although they can be found all over the world in introduced (and captive) populations, the pheasant genera native range is restricted to Eurasia. The classification "pheasant" is paraphyletic, as birds referred to as pheasants are included within both the subfamilies Phasianinae and Pavoninae, and in many cases are more closely related to smaller phasianids, grouse, and turkey (formerly classified in Perdicinae, Tetraoninae, and Meleagridinae) than to other pheasants. Pheasants are characterised by strong sexual dimorphism, males being highly decorated with bright colours and adornments such as wattles. Males are usually larger than females and have longer tails. Males play no part in rearing the young. A pheasants call or cry can be recognised due to the fact it sounds like a rusty sink or valve being turned. Pheasants eat mostly seeds, grains, roots, and berries, while in the ...
Paul S. Mischel (born July 13, 1962) is an American physician-scientist whose laboratory has made pioneering discoveries in the pathogenesis of human cancer. He is currently a Professor and Vice Chair of Research for the Department of Pathology and Institute Scholar of ChEM-H, Stanford University. Mischel was elected into the American Society for Clinical Investigation (ASCI), serving as ASCI president in 2010/11. He was inducted into the Association of American Physicians, and was elected as a fellow of the American Association for the Advancement of Science. Mischel was born on July 13, 1962. After losing his father to cancer, he became committed to a career in cancer research. He attended the University of Pennsylvania and received his M.D. from Cornell University Medical College in 1991, graduating Alpha Omega Alpha. Mischel completed residency training in Anatomic Pathology and Neuropathology at UCLA, followed by post-doctoral research training with Louis Reichardt at HHMI-UCSF. Mischel ...
... is a moth of the family Sphingidae. It is known from highland forest in central Kenya and also in Zimbabwe. The length of the forewings is about 24 mm for males and 26 mm for females. It is similar to Temnora griseata griseata but the upperside of the head has a dark brown median longitudinal crest, the forewing apex and tornus are more acute and the outer margin is more deeply excavated below the apex. The forewing upperside ground colour is dark brown and the pattern of transverse lines is more contrasted. Temnora subapicalis subapicalis Temnora subapicalis hayesi Darge, 1975 (Rwanda) "CATE Creating a Taxonomic eScience - Sphingidae". Cate-sphingidae.org. Retrieved 2011-10-25.[permanent dead link] Carcasson, R. H. (1967). "Revised Catalogue of the African Sphingidae (Lepidoptera) with Descriptions of the East African species". Journal of the East Africa Natural History Society and National Museum. 26 (3): 1-173 - via Biodiversity Heritage Library. v t e (All articles with ...
... is a name under which singer-songwriter Dan Michaelson records and performs. They have previously stated that they are inspired by Leonard Cohen, Johnny Cash, Etta James and Dusty Springfield. Following the release of Blindspot in 2013 and Sudden Fiction in 2011, the band released Distance in August 2014. Memory was released in May 2016. Albums Singles Simpson, Dave (5 May 2016). "Dan Michaelson and the Coastguards: Memory review - magical, melancholy songs". Theguardian.com. Retrieved 21 October 2020. Dan Michaelson and The Coastguards official site Dan Michaelson and The Coastguards myspace page The state51 Conspiracy official site Official YouTube (Use dmy dates from June 2020, Use British English from June 2016, Articles needing additional references from October 2016, All articles needing additional references, Articles with hCards, Pages using infobox musical artist with associated acts, Articles with ISNI identifiers, Articles with MusicBrainz ...
The Edmonton Drillers were a North American Soccer League team that played both outdoors and indoors from 1979 to 1982, at the peak of the league's success. The team was brought to Edmonton by local entrepreneur and Edmonton Oilers owner Peter Pocklington, after witnessing the strong support for Brian Rice's Edmonton Black Gold team in 1978. Previous to playing in Edmonton, the team was known as the Oakland Stompers, Hartford Bicentennials and Connecticut Bicentennials. Joe Petrone was the Drillers general manager for their entire existence. The Drillers were coached in 1979 and 1980 by Hans Kraay, who brought a number of players with him from the Netherlands. After Kraay, Timo Liekoski took over as coach in 1981, while Patrone would serve as the team's final caretaker coach until the team folded at the end of the 1982 season. During the outdoor season, the Drillers played their home games at Commonwealth Stadium, but dwindling crowds during the final year saw the team move to much older and ...
... is a compilation album featuring songs from various artists in all genres of popular music. The songs were picked from among some of the most popular during the autumn of 2006 in Australia. The album was released on 26 March 2006. Mariah Carey - "Don't Forget About Us" (3:54) Chris Brown - "Run It!" (3:14) Gwen Stefani - "Luxurious" (4:26) TV Rock - "Flaunt It" (3:29) Rogue Traders - "Watching You" (3:29) Lee Harding - "Wasabi" (3:00) The Black Eyed Peas - "My Humps" (4:12) The Pussycat Dolls - "Stickwitu" (3:29) Sugababes - "Push the Button" (3:38) Kelly Clarkson - "Walk Away" (3:08) Rihanna - "If It's Lovin' that You Want" (3:28) Daddy Yankee - "Gasolina" (3:15) Nickelback - "Far Away" (3:59) Bernard Fanning - "Wish You Well" (2:31) Pete Murray - "Class A" (3:05) Shannon Noll - "Lift" (3:57) Lindsay Lohan - "Confessions of a Broken Heart (Daughter to Father)" (3:43) Kate DeAraugo - "Maybe Tonight" (3:38) Backstreet Boys - "I Still..." (3:49) Meck featuring Leo ...
Kızılpınar Atatürk is a neighborhood in Çerkezköy district of Tekirdağ Province, Turkey. At 41°16′N 27°58′E / 41.267°N 27.967°E / 41.267; 27.967 it is almost merged to Çerkezköy. Distance to Tekirdağ is about 55 kilometres (34 mi). The population of Kızılpınar Atatürk is 22,966 "Turkstat". Turkish Statistical Institute. Retrieved 4 February 2021. "Turkstat". Turkish Statistical Institute. Retrieved 4 February 2021. Tekirdağ Governor's Official Website Metropolitan Municipality of Tekirdağ District municipality's Official Website v t e (Pages with non-numeric formatnum arguments, Articles with short description, Short description matches Wikidata, Articles needing additional references from March 2020, All articles needing additional references, Coordinates on Wikidata, AC with 0 elements, Populated places in Tekirdağ Province, Towns in Turkey, Çerkezköy District, Things named after Mustafa Kemal Atatürk, All stub articles, Marmara Region geography stubs ...
Clorazepate indications, usages and related health products lists ... Tablets; Oral; Clorazepate Dipotassium 3.75 mg*Tablets; Oral; ... Clorazepate information about active ingredients, pharmaceutical forms and doses by Lederle, ... Available forms, composition and doses of Clorazepate:. *Tablets; Oral; Clorazepate Dipotassium 15 mg* ... N05BA05 - Potassium Clorazepate. Pharmaceutical companies: manufacturers, researchers, developers, local distributors and ...
Round and has been identified as Clorazepate Dipotassium 7.5 mg. It is supplied by Watson Pharmaceuticals. ... Clorazepate Dipotassium. Imprint. 75 WATSON 364. Strength. 7.5 mg. Color. Beige. Shape. Round. Availability. Prescription only ... Pill with imprint 75 WATSON 364 is Beige, Round and has been identified as Clorazepate Dipotassium 7.5 mg. It is supplied by ... Clorazepate is used in the treatment of anxiety; alcohol withdrawal; seizure prevention and belongs to the drug class ...
Clorazepate Dipotassium D3.438.79.80.180 D3.633.100.79.80.180 Clot Retraction G9.188.124.560.600.180 G9.188.390.600.180 ...
Clorazepate. Clorazepate Monopotassium. Clorazepic Acid. Dipotassium Chlorazepate. Tranxene. Tranxilium. Tree number(s):. ... Clorazepate Dipotassium - Preferred Concept UI. M0004628. Scope note. A water-soluble benzodiazepine derivative effective in ... Clorazepate Monopotassium - Related but not broader or narrower Concept UI. M0004629. Preferred term. Clorazepate Monopotassium ...
Clorazepate (dipotassium); Clotiazepam; Cloxazolam; Clozapine; Dalmane; Delorazepam; Diazepam; Estazolam; Etizolam; Fludiazepam ...
Clorazepate Dipotassium. 4. Y. 45%. 50%. 45%. 180/30. Y. N. Clotrimazole. 2. N. $5. $20. $5. N. N. Clotrimazole And ...
clorazepate dipotassium Nursing Considerations & Management 0 *. folic acid (folate) Nursing Considerations & Management ...
2, Cladribine, Clarithromycin, Clobetasol propionate,Clofibrate,Clomiphene citrate, Clomiphene citrate,Clorazepate dipotassium, ...
CLORAZEPATE DIPOTASSIUM 02131=ESOMEPRAZOLE MAGNESIUM 02132=LORCET-HD 02133=NITROGLYCERIN TRANSLINGUAL 02134= ... CLORAZEPATE d00199=CLOZAPINE d00200=CROMOLYN d00202=DACARBAZINE d00203=DACTINOMYCIN d00204=DANAZOL d00205 ...
Clorazepate Dipotassium D3.438.79.80.180 D3.633.100.79.80.180 Clot Retraction G9.188.124.560.600.180 G9.188.390.600.180 ...
Clorazepate dipotassium tablets can cause abuse and dependence. o. Do not stop taking clorazepate dipotassium tablets all of a ... Do not take clorazepate dipotassium tablets if you: •. are allergic to clorazepate dipotassium or any of the ingredients in ... Keep clorazepate dipotassium tablets in a tightly closed container, dry, and out of the light. •. Keep clorazepate dipotassium ... Stopping clorazepate dipotassium tablets suddenly can cause serious problems. •. If you take too many clorazepate dipotassium ...
Dipotassium clorazepate. Fast. 48. Yes. Diazepam. Fast. 20 50. Yes. Estazolam. Fast. 10 24. No. ...
Clorazepate Dipotassium / adverse effects Actions. * Search in PubMed * Search in MeSH * Add to Search ... Double-blind comparison of buspirone and clorazepate in anxious outpatients. Cohn JB, Bowden CL, Fisher JG, Rodos JJ. Cohn JB, ... The mean daily doses of the various treatments were buspirone, 20 mg; diazepam, 20 mg; clorazepate, 24 mg; lorazepam, 3 mg; and ... Nausea was reported more frequently in buspirone-treated patients than in those receiving clorazepate, diazepam, or alprazolam ...
Clorazepate Dipotassium / adverse effects Actions. * Search in PubMed * Search in MeSH * Add to Search ... Double-blind comparison of buspirone and clorazepate in anxious outpatients. Cohn JB, Bowden CL, Fisher JG, Rodos JJ. Cohn JB, ... The mean daily doses of the various treatments were buspirone, 20 mg; diazepam, 20 mg; clorazepate, 24 mg; lorazepam, 3 mg; and ... Nausea was reported more frequently in buspirone-treated patients than in those receiving clorazepate, diazepam, or alprazolam ...
Clorazepate Dipotassium,N0000006513, Calcium,N0000006512, Calcitriol,N0000006511, p-Hydroxyamphetamine,N0000006510, Calcitonin, ...
Clorazepate dipotassium Current Synonym true false 2476900012 Dipotassium clorazepate Current Synonym true false ... Dipotassium clorazepate (substance). Code System Preferred Concept Name. Dipotassium clorazepate (substance). Concept Status. ...
Clorazepate Clorazepate Monopotassium Clorazepic Acid Dipotassium Chlorazepate Tranxene Tranxilium Pharm Action. ... Clorazepate Dipotassium Preferred Term Term UI T008744. Date01/01/1999. LexicalTag NON. ThesaurusID ... Clorazepate Dipotassium Preferred Concept UI. M0004628. Registry Number. 63FN7G03XY. Related Numbers. 57109-90-7. D51WO0G0L4. ... Clorazepate Monopotassium Related Concept UI. M0004629. Registry Number. MS63G8NQUI. Terms. Clorazepate Monopotassium Preferred ...
Clorazepate Clorazepate Monopotassium Clorazepic Acid Dipotassium Chlorazepate Tranxene Tranxilium Pharm Action. ... Clorazepate Dipotassium Preferred Term Term UI T008744. Date01/01/1999. LexicalTag NON. ThesaurusID ... Clorazepate Dipotassium Preferred Concept UI. M0004628. Registry Number. 63FN7G03XY. Related Numbers. 57109-90-7. D51WO0G0L4. ... Clorazepate Monopotassium Related Concept UI. M0004629. Registry Number. MS63G8NQUI. Terms. Clorazepate Monopotassium Preferred ...
... clorazepate), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, ... clorazepate dipotassium oral CLORAZEPATE - ORAL (klor-AZ-e-pate) COMMON BRAND NAME(S): Tranxene WARNING: Clorazepate has a risk ... encoded search term (clorazepate (Tranxene SD%2C Tranxene T-Tab)) and clorazepate (Tranxene SD, Tranxene T-Tab) What to Read ... clorazepate and iloperidone both increase sedation. Use Caution/Monitor.. iloperidone increases levels of clorazepate by ...
... clorazepate dipotassium, E0070207,Diaparene,methylbenzethonium chloride, E0070236,Silvadene,silver sulfadiazine, E0070243, ... clorazepate dipotassium, E0301034,Clostilbegit,enclomiphene citrate, E0301035,Klostilbegit,enclomiphene citrate, E0301040, ...
Clorazepate dipotassium (57109-90-7) 8 alternate names. 3 suppliers. METHYLPREDNISOLONE SODIUM SUCCINATE (2375-03-3) 8 ...
Clorazepate Dipotassium D3.438.79.80.180 D3.633.100.79.80.180 Clot Retraction G9.188.124.560.600.180 G9.188.390.600.180 ...
ANTI-ANXIETY AGENTS CLORAZEPATE DIPOTASSIUM ANTI-ANXIETY AGENTS DIAZEPAM ANTI-ANXIETY AGENTS DOXEPIN ANTI-ANXIETY AGENTS ... GABA AGENTS CLORAZEPATE DIPOTASSIUM GABA AGENTS CLOZAPINE GABA AGENTS DIAZEPAM GABA AGENTS FLUMAZENIL GABA AGENTS FLUNITRAZEPAM ... GABA MODULATORS CLORAZEPATE DIPOTASSIUM GABA MODULATORS DIAZEPAM GABA MODULATORS FLUMAZENIL GABA MODULATORS FLUNITRAZEPAM GABA ... PSYCHOTROPIC DRUGS CLORAZEPATE DIPOTASSIUM PSYCHOTROPIC DRUGS CLORGYLINE PSYCHOTROPIC DRUGS CLOZAPINE PSYCHOTROPIC DRUGS DEANOL ...
Clorazepate Dipotassium D3.438.79.80.180 D3.633.100.79.80.180 Clot Retraction G9.188.124.560.600.180 G9.188.390.600.180 ...
Clorazepate Dipotassium D3.438.79.80.180 D3.633.100.79.80.180 Clot Retraction G9.188.124.560.600.180 G9.188.390.600.180 ...
Clorazepate Dipotassium D3.438.79.80.180 D3.633.100.79.80.180 Clot Retraction G9.188.124.560.600.180 G9.188.390.600.180 ...
... stylosa untyped s616 tauricum contergan dipropoxybenzidine carers oostatic sulfolobaceae papanicolaou zoletil dipotassium ... methyltransferase stenosperma persuasion lactisole syllable dehydroguanidinohydantoin neuroborreliosis benzylmethyl clorazepate ...
  • Each Clorazepate Dipotassium Tablet, USP 3.75 mg contains clorazepate equivalent to 2.9 mg. (nih.gov)
  • Inactive ingredients for Clorazepate Dipotassium Tablets, USP: Colloidal Silicon Dioxide, FD&C Blue No.2 Aluminum Lake (3.75 mg), FD&C Yellow No.6 Aluminum Lake (7.5 mg), Magnesium Oxide, Potassium Chloride, Potassium Carbonate, Microcrystalline Cellulose, Croscarmellose Sodium and Magnesium Stearate. (nih.gov)
  • A first report of jaundice and hepatic necrosis probably due to potassium clorazepate is described. (nih.gov)
  • Patient acceptance as a factor in the effectiveness of treatment: an open assessment of potassium clorazepate ('Tranxene') and lorazepam in anxiety. (nih.gov)
  • Esophageal burn due to chlorazepate dipotassium (Tranxene). (nih.gov)
  • Chemically, clorazepate dipotassium is a benzodiazepine. (nih.gov)
  • Risk of withdrawal was investigated in a prospective, double-blind comparison of clorazepate dipotassium, a benzodiazepine with a long half-life, and the nonbenzodiazepine buspirone hydrochloride in the long-term treatment of anxious outpatients. (nih.gov)
  • Patients were treated with therapeutic doses of clorazepate dipotassium (15 to 60 mg/d) or buspirone hydrochloride (10 to 40 mg/d) for six continuous months before their tranquilizer therapy was blindly and abruptly stopped. (nih.gov)
  • Abrupt discontinuation or rapid dosage reduction of clorazepate dipotassium after continued use may precipitate acute withdrawal reactions, which can be life-threatening. (nih.gov)
  • To reduce the risk of withdrawal reactions, use a gradual taper to discontinue clorazepate dipotassium or reduce the dosage (See DOSAGE AND ADMINISTRATION and WARNINGS). (nih.gov)
  • There was a significant increase in symptom severity consistent with a withdrawal reaction for the clorazepate group but not the buspirone group. (nih.gov)
  • For the clorazepate group, there was a suggestion that previous discontinuous exposure to benzodiazepines might sensitize patients to subsequent withdrawal effects. (nih.gov)
  • Clorazepate and lorazepam: clinical improvement and rebound anxiety. (nih.gov)
  • Before prescribing clorazepate dipotassium and throughout out treatment, assess each patient's risk for abuse, misuse, and addiction (See WARNINGS). (nih.gov)
  • If a decision is made to prescribe clorazepate dipotassium tablets concomitantly with opioids, prescribe the lowest effective dosages and minimum durations of concomitant use, and follow patients closely for signs and symptoms of respiratory depression and sedation. (nih.gov)
  • Inactive ingredients for clorazepate dipotassium tablets: croscarmellose sodium, magnesium oxide, magnesium stearate, microcrystalline cellulose, potassium carbonate, sodium chloride and sodium lauryl sulfate. (nih.gov)
  • clorazepate, calcium/magnesium/potassium/sodium oxybates. (medscape.com)
  • Plasma levels of nordiazepam increase proportionally with clorazepate dipotassium dose and show moderate accumulation with repeated administration. (nih.gov)
  • abametapir will increase the level or effect of clorazepate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (medscape.com)
  • conivaptan will increase the level or effect of clorazepate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (medscape.com)
  • idelalisib will increase the level or effect of clorazepate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (medscape.com)
  • The incidence of drowsiness in buspirone-treated patients was significantly less than that in each of the groups receiving diazepam (32 percent), clorazepate (26 percent), lorazepam (58 percent), or alprazolam (43 percent). (nih.gov)
  • Depression occurred less frequently in buspirone-treated patients than in those receiving clorazepate, diazepam, or lorazepam. (nih.gov)
  • Impotence occurred only in clorazepate- and lorazepam-treated patients. (nih.gov)
  • Decreased libido occurred more frequently in diazepam-treated patients, whereas increased libido was more frequent in clorazepate-treated patients. (nih.gov)
  • Clorazepate dipotassium tablets are contraindicated in patients with a known hypersensitivity to the drug and in those with acute narrow angle glaucoma. (nih.gov)