Clopenthixol
A double blind comparison of zuclopenthixol acetate with haloperidol in the management of acutely disturbed schizophrenics. (1/11)
The aim of this study was to evaluate the efficacy and side effects of zuclopenthixol acetate compared with haloperidol in the management of the acutely disturbed schizophrenic patient. Suitable subjects diagnosed as having schizophreniform disorder or acute exacerbation of schizophrenia admitted to the psychiatric wards Hospital Kuala Lumpur were randomised to receive either zuclopenthixol acetate or haloperidol. They were rated blind for three consecutive days using the Brief Psychiatric Rating Scale (BPRS), Clinical Global Impression (CGI) and UKU Side Effects Scale. Apart from repeat injections of the same medication, no other anti-psychotic was given for the duration of the study. 50 subjects entered the study of which 44 completed. 23 were given zuclopenthixol acetate and 21 haloperidol. Both groups significantly reduced BPRS and CGI scores on all 3 days compared to the initial rating (p < 0.001). There was however no difference between the zuclopenthixol acetate and haloperidol group scores on all days (p > 0.05). More subjects on haloperidol than zuclopenthixol required more than 1 injection during the study. Both groups had minimal side effects. Zuclopenthixol acetate was effective in the management of the acutely disturbed schizophrenic. (+info)The interaction of neuroleptic and muscarinic agents with central dopaminergic systems. (2/11)
1. The effect of muscarinic and neuroleptic agents on the turning behaviour induced by methamphetamine and apomorphine in rats with unilateral lesions of the substantia nigra induced by 6-hydroxydopamine has been examined. 2. Turning towards the side of the lesion induced by (+)-methamphetamine (5 mg/kg) was inhibited by alpha-flupenthixol (1 mg/kg) and alpha-clopenthixol (8 mg/kg) but not by high doses of their beta-isomers. 3. Turning was inhibited by chlorpromazine (4 mg/kg) and pimozide (0.2 mg/kg). Thioridazine and clozapine (16 mg/kg) were ineffective. Turning in the same direction produced by scopolamine (10 mg/kg) was also inhibited by alpha-flupenthixol (1 mg/kg) and pimozide (0.25 mg/kg). 4. Turning produced by methamphetamine (5 mg/kg) was inhibited by oxotremorine (0.75 mg/kg) even in the presence of methylatropine (5 mg/kg). 5. Turning away from the side of the lesion induced by apomorphine (0.1 mg/kg) was inhibited by oxotremorine (0.75 mg/kg) but not by thioridazine or clozapine (16 mg/kg). 6. These results are discussed with regard to the mode of action of neuroleptic drugs in producing anti-psychotic effects and drug-induced Parkinsonism. (+info)Concentrations of cis(Z)-clopenthixol and trans(E)-clopenthixol in a lethal case involving zuclopenthixol, diazepam, and cyamemazine. (3/11)
cis(Z)-Clopenthixol and trans(E)-clopenthixol were determined by gas chromatography-mass spectrometry and high-performance liquid chromatography-diode-array detection in necropic samples from a postmortem case. The peripheral blood concentrations of cis(Z)-clopenthixol and trans(E)-clopenthixol were 278 and 177 ng/mL, respectively. The level of the active cis(Z)-isomer is within the toxic range. Other associated drugs' concentrations were within their therapeutic ranges. Postmortem redistribution of the drug and instability of the drug due to trans-isomerization were discussed. (+info)Flow-injection chemiluminometric determination of some thioxanthene derivatives in pharmaceutical formulations and biological fluids using the [Ru(dipy)3(2+)]-Ce(IV) system. (4/11)
A flow-injection (FI) methodology using tris(2,2'-dipyridyl)ruthenium(II), [Ru(dipy)3(2+)], chemiluminescence (CL) was developed for the rapid and sensitive determination of three thioxanthene derivatives, namely zuclopenthixol hydrochloride, flupentixol hydrochloride and thiothixene. The method is based on the CL reaction of the studied thioxanthenes with [Ru(dipy)3(2+)] and Ce(IV) in a sulfuric acid medium. Under the optimum conditions, calibration graphs were obtained over the concentration ranges 0.002-6 migrograms/ml for zuclopenthixol hydrochloride, 0.5-15 micrograms/ml for flupentixol hydrochloride and 0.05-7.5 micrograms/ml for thiothixene. The limits of detection (s/n = 3) were 4.2 x 10(-9) mol/l zuclopenthixol hydrochloride, 2 x 10(-8) mol/l flupentixol hydrochloride and 4.5 x 10(-8) mol/l thiothixene. The method was successfully applied to the determination of these compounds in dosage forms and biological fluids. (+info)Comparison of analgesic techniques for antler removal in wapiti. (5/11)
The purpose of this research was to compare the effectiveness of ring block anesthesia (LA) and electroanesthesia (A) for antler removal in elk given a long-acting tranquilizer to remove stress from restraint. Thirty-two male wapiti were given 1 mg/kg body weight of zuclopenthixol acetate; the next day, they were restrained in a hydraulic chute, provided with electroanesthesia or a lidocaine ring block, and had their antlers removed. Behavioral response to antler removal was scored. Significantly more (P = 0.032) animals responded to antler removal in the EA group. Heart rates and arterial pressures were measured by a catheter connected to a physiological monitor. Heart rate increased significantly over time with EA, but not with LA. Heart rate increased from baseline significantly more in the EA group immediately prior to antler removal (P = 0.017), immediately post antler removal (P = 0.001), and at 1 min post antler removal (P = 0.037). It was concluded that EA is not as effective a method of anesthesia as is LA for antler removal. (+info)Rapid tranquillisation: time for a reappraisal of options for parenteral therapy. (6/11)
BACKGROUND: When parenteral treatments are indicated for acutely disturbed behaviour, previous guidelines have recommended droperidol or haloperidol in combination with benzodiazepines. However, there has been recent concern over cardiotoxicity and sudden death associated with some antipsychotic medication and droperidol has now been withdrawn. AIMS: To ascertain what alternatives can be recommended to replace intramuscular droperidol. METHOD: Selective review of current guidelines and the literature pertaining to rapid parenteral tranquillisation. RESULTS: Current guidelines recommend haloperidol as an alternative to droperidol. There is evidence of cardiotoxicity with haloperidol and it has a propensity to cause extrapyramidal side-effects that may exacerbate disturbed behaviour and reduce longer-term compliance. The rapid-acting intramuscular formulations of atypical antipsychotic agents show promise. CONCLUSIONS: It is recommended that the mainstay of pharmacological rapid tranquillisation should be parenteral benzodiazepines used with due care. (+info)Zuclopenthixol in adults with intellectual disabilities and aggressive behaviours: discontinuation study. (7/11)
We investigated the effects of zuclopenthixol on aggressive behaviour in patients with intellectual disabilities by randomly withdrawing it after a 6-week period of open treatment. Of the 49 patients responding to the treatment, 39 took part in a randomised withdrawal trial. The placebo subgroup (n=20) showed more aggressive behaviour as indicated by outcomes observed by external raters on the Modified Overt Aggression Scale than did the continuing subgroup (n=19). The results indicate that discontinuation of zuclopenthixolin this population leads to an increase in aggressive behaviour. (+info)Fatal exertional heat stroke in a patient receiving zuclopenthixol, quetiapine and benztropine. (8/11)
OBJECTIVE: To report a case of fatal exertional heat stroke associated with the use of zuclopenthixol, quetiapine and benztropine. CASE SUMMARY: A 36-year-old male with a history of schizophrenia and bipolar disease was working as a roofer during the third day of a heat wave. His medications included zuclopenthixol, quetiapine, benztropine, carbamazepine and levothyroxine. He developed loss of consciousness late in the day and presented to hospital with a Glasgow Coma Scale 3 and a rectal temperature of 42.2 degrees C. He progressed to severe multiple organ dysfunction and asystole, and expired the following morning. Neuroleptic and anticholinergic agents have long been associated with heat alteration, but there are few reports involving the newer antipsychotic agents. Physicians and pharmacists should ensure that appropriate counseling is given to patients receiving these medications regarding early recognition of signs and symptoms and prompt treatment of heat related illness and heat stroke. (+info)
Effects of Thioxanthene Containing Anti-Psychotic and Anti-Platelet Drug Combination on Mean Platelet Volume and Platelet...
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Clopenthixol
... (Sordinol), also known as clopentixol, is a typical antipsychotic drug of the thioxanthene class. It was ... ISBN 978-3-527-31058-6. Gravem A, Engstrand E, Guleng RJ (November 1978). "Cis(Z)-clopenthixol and clopenthixol (Sordinol) in ... Clopenthixol is a mixture of cis and trans isomers. Zuclopenthixol, the pure cis isomer, was later introduced by Lundbeck in ... Clopenthixol at the US National Library of Medicine Medical Subject Headings (MeSH) v t e (Articles with short description, ...
List of dopaminergic drugs
Clopenthixol • Chlorpromazine • Chlorprothixene • Droperidol • Flupentixol • Fluphenazine • Fluspirilene • Haloperidol • ...
Tiotixene
Analogues include chlorprothixene, clopenthixol, flupentixol, and zuclopenthixol. "[email protected]: FDA-Approved Drugs". José Miguel ...
Atypical antipsychotic
34 (1): 1-6. Jørgensen A, Overø KF (1980). "Clopenthixol and flupenthixol depot preparations in outpatient schizophrenics. III ...
Paliperidone palmitate
34 (1): 1-6. Jørgensen A, Overø KF (1980). "Clopenthixol and flupenthixol depot preparations in outpatient schizophrenics. III ...
Perphenazine
34 (1): 1-6. Jørgensen A, Overø KF (1980). "Clopenthixol and flupenthixol depot preparations in outpatient schizophrenics. III ...
Typical antipsychotic
34 (1): 1-6. Jørgensen A, Overø KF (1980). "Clopenthixol and flupenthixol depot preparations in outpatient schizophrenics. III ...
Fluspirilene
34 (1): 1-6. Jørgensen A, Overø KF (1980). "Clopenthixol and flupenthixol depot preparations in outpatient schizophrenics. III ...
Pipotiazine
34 (1): 1-6. Jørgensen A, Overø KF (1980). "Clopenthixol and flupenthixol depot preparations in outpatient schizophrenics. III ...
Paliperidone
34 (1): 1-6. Jørgensen A, Overø KF (1980). "Clopenthixol and flupenthixol depot preparations in outpatient schizophrenics. III ...
Fluphenazine
34 (1): 1-6. Jørgensen A, Overø KF (1980). "Clopenthixol and flupenthixol depot preparations in outpatient schizophrenics. III ...
Aripiprazole
34 (1): 1-6. Jørgensen A, Overø KF (1980). "Clopenthixol and flupenthixol depot preparations in outpatient schizophrenics. III ...
Antipsychotic ester
Bromperidol decanoate Clopentixol decanoate Flupentixol decanoate Fluphenazine decanoate Fluphenazine enanthate Haloperidol ... 34 (1): 1-6. Jørgensen A, Overø KF (1980). "Clopenthixol and flupenthixol depot preparations in outpatient schizophrenics. III ...
Viscoleo
34 (1): 1-6. Jørgensen A, Overø KF (1980). "Clopenthixol and flupenthixol depot preparations in outpatient schizophrenics. III ... It is used as an oil vehicle for several depot antipsychotics including clopentixol decanoate, flupentixol decanoate, ...
Oxyprothepin decanoate
34 (1): 1-6. Jørgensen A, Overø KF (1980). "Clopenthixol and flupenthixol depot preparations in outpatient schizophrenics. III ...
Perphenazine enanthate
34 (1): 1-6. Jørgensen A, Overø KF (1980). "Clopenthixol and flupenthixol depot preparations in outpatient schizophrenics. III ...
Bromperidol
34 (1): 1-6. Jørgensen A, Overø KF (1980). "Clopenthixol and flupenthixol depot preparations in outpatient schizophrenics. III ...
Aripiprazole lauroxil
34 (1): 1-6. Jørgensen A, Overø KF (1980). "Clopenthixol and flupenthixol depot preparations in outpatient schizophrenics. III ...
Bromperidol decanoate
34 (1): 1-6. Jørgensen A, Overø KF (1980). "Clopenthixol and flupenthixol depot preparations in outpatient schizophrenics. III ...
Haloperidol decanoate
34 (1): 1-6. Jørgensen A, Overø KF (1980). "Clopenthixol and flupenthixol depot preparations in outpatient schizophrenics. III ...
Risperidone
34 (1): 1-6. Jørgensen A, Overø KF (1980). "Clopenthixol and flupenthixol depot preparations in outpatient schizophrenics. III ...
Zuclopenthixol
It is the cis-isomer of clopenthixol (Sordinol, Ciatyl). Clopenthixol was introduced in 1961, while zuclopenthixol was ...
Dopamine antagonist
Chlorpromazine binds D3 with the highest affinity, but also binds D1, D2, D4 and D5 Clopenthixol Droperidol is used as an ...
Benzhydryl compounds
... clopenthixol, chlorprothixene, flupentixol, thiothixene, zuclopenthixol Tricyclic and piperidine: pimethixene, cyproheptadine ...
List of MeSH codes (D03)
... clopenthixol MeSH D03.494.953.704.360 - flupenthixol MeSH D03.494.953.704.450 - hycanthone MeSH D03.494.953.704.500 - ...
Thioxanthene
Clopenthixol (Sordinol) Flupenthixol (Depixol, Fluanxol) Thiothixene (Navane) Zuclopenthixol (Cisordinol, Clopixol, Acuphase) ...
List of drugs: Cj-Cl
... clopenthixol (INN) cloperastine (INN) cloperidone (INN) clopidogrel (INN) clopidol (INN) clopimozide (INN) clopipazan (INN) ...
C22H25ClN2OS
The molecular formula C22H25ClN2OS (molar mass: 400.96 g/mol) may refer to: Clopenthixol, a typical antipsychotic drug ...
List of antipsychotics
Bromperidol decanoate Clopenthixol decanoate Flupentixol decanoate Flupentixol palmitate Fluphenazine decanoate Fluphenazine ...
ATC code N05
Oxypertine N05AE02 Molindone N05AE03 Sertindole N05AE04 Ziprasidone N05AE05 Lurasidone N05AF01 Flupentixol N05AF02 Clopenthixol ...
Clopenthixol | C22H25ClN2OS | ChemSpider
The dilemma of polypharmacy in psychosis: is it worth combin... : International Clinical Psychopharmacology
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DeCS
Clopenthixol - Preferred Concept UI. M0004622. Scope note. A thioxanthene with therapeutic actions similar to the phenothiazine ... clopentixol. Scope note:. Un tioxanteno con acciones terapéuticas similares a las de las fenotiazinas antipsicóticas. Es un ... Clopentixol Descriptor French: Clopenthixol Entry term(s):. Cisordinol. Zuclopenthixol. alpha Clopenthixol. alpha-Clopenthixol ...
Trifluoromethylphenylpiperazine - Wikipedia
The combination of BZP and TFMPP has been associated with a range of side effects, including insomnia, anxiety, nausea and vomiting, headaches and muscle aches which may resemble migraine, seizures, impotence, and rarely psychosis,[3] as well as a prolonged and unpleasant hangover effect. These side effects tend to be significantly worsened when the BZP/TFMPP mix is consumed alongside alcohol, especially the headache, nausea, and hangover. However, it is difficult to say how many of these side effects are produced by TFMPP itself, as it has rarely been marketed without BZP also being present, and all of the side effects mentioned are also produced by BZP (which has been sold as a single drug). Studies into other related piperazine drugs such as mCPP suggest that certain side effects such as anxiety, headache and nausea are common to all drugs of this class, and pills containing TFMPP are reported by users to produce comparatively more severe hangover effects than those containing only BZP. The ...
Pesquisa | Portal Regional da BVS
Agressão/efeitos dos fármacos , Clopentixol/farmacologia , Clopentixol/uso terapêutico , Monitoramento de Medicamentos , ... Clopentixol/análogos & derivados , Clopentixol/uso terapêutico , Substituição de Medicamentos , Humanos , Masculino , Adesão à ... Clopentixol/efeitos adversos , Clopentixol/uso terapêutico , Feminino , Humanos , Esquizofrenia/tratamento farmacológico , ... Clopentixol/efeitos adversos , Clopentixol/metabolismo , Dinamarca , Antagonistas de Dopamina/efeitos adversos , Antagonistas ...
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Vardenafil - WikiProjectMed
Vardenafil, sold under the brand name Levitra among others, is a medication used to treat erectile dysfunction.[1] It is taken by mouth.[1] Onset is generally in 30 to 60 minutes.[1] There is no evidence of benefit of one agent, within this family, over another.[2] Common side effects include headache.[1] Other side effects may include allergic reactions, low blood pressure, QT prolongation, and priapism.[2] A lower dose is recommended in those with moderate liver problems.[2] Use with nitrovasodilators is not recommended.[2] It is a PDE5 inhibitor and works by decreasing the breakdown of cyclic guanosine monophosphate (cGMP).[1] Vardenafil was approved for medical use in Europe and the United States in 2003.[1][2] It is available as a generic medication.[3] In the United Kingdom it costs about 5 pounds per 10 mg dose.[3] In the United States this amount costs about 17 USD as of 2021.[4] ...
Perospirone - WikiProjectMed
Benzatropine
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BP trans clopenthixol acetate dihydrochloride
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Neuroleptic Malignant Syndrome - StatPearls - NCBI Bookshelf
Neuroleptic malignant syndrome (NMS) is a life-threatening syndrome associated with the use of dopamine-receptor antagonist medications or with the rapid withdrawal of dopaminergic medications. NMS has been associated with virtually every neuroleptic agent but is more commonly reported with the typical antipsychotics like haloperidol and fluphenazine. Classic clinical characteristics include mental status changes, fever, muscle rigidity, and autonomic instability. While uncommon, NMS remains an important part of the differential diagnosis of fever and mental status changes because it requires early diagnosis and treatment to prevent significant mortality and death. Treatment involves immediately discontinuing the offending agent, aggressive supportive care to manage and prevent complications, and pharmacologic therapy in severe cases. The empiric medications most frequently used for refractory NMS include bromocriptine mesylate, a dopamine agonist, and dantrolene sodium, a muscle relaxant. If the
MeSH Browser
Clopenthixol Preferred Concept UI. M0004622. Registry Number. 982-24-1. Related Numbers. 47ISU063SG. 53772-83-1. Scope Note. A ... Clopenthixol Preferred Term Term UI T008730. Date01/01/1999. LexicalTag NON. ThesaurusID ... alpha-Clopenthixol Term UI T640567. Date05/13/2005. LexicalTag NON. ThesaurusID NLM (2006). ... alpha-Clopenthixol Pharm Action. Antipsychotic Agents. Dopamine Antagonists. Registry Number. 982-24-1. Related Numbers. ...
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MeSH Browser
Clopenthixol Preferred Concept UI. M0004622. Registry Number. 982-24-1. Related Numbers. 47ISU063SG. 53772-83-1. Scope Note. A ... Clopenthixol Preferred Term Term UI T008730. Date01/01/1999. LexicalTag NON. ThesaurusID ... alpha-Clopenthixol Term UI T640567. Date05/13/2005. LexicalTag NON. ThesaurusID NLM (2006). ... alpha-Clopenthixol Pharm Action. Antipsychotic Agents. Dopamine Antagonists. Registry Number. 982-24-1. Related Numbers. ...
NLM History of Medicine Division Finding Aids
"Haloperidol clopenthixol and chlorpromazine in chronic schizophrenia" - J. of Nerv. and Ment. Dis., 1972 File - Box: 43, Folder ... Haloperidol clopenthixol and chlorpromazine in chronic schizophrenia - J. of Nerv. and Ment. Dis., 1972, Box: 43, Folder: 28. ... Haloperidol clopenthixol and chlorpromazine in chronic schizophrenia - J. of Nerv. and Ment. Dis., 1972, Box: 43, Folder: 28. ... "Haloperidol clopenthixol and chlorpromazine in chronic schizophrenia" - J. of Nerv. and Ment. Dis., 1972 ...
Desmethylclozapine - Wikipedia
Atypical Antipsychotic - Mental Health Matters
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These were haloperidol, clopenthixol, tefludazine, and setoperone, all tested in the dosage range of .01 to .25 mg/kg and ... These were haloperidol, clopenthixol, tefludazine, and setoperone, all tested in the dosage range of .01 to .25 mg/kg and ... These were haloperidol, clopenthixol, tefludazine, and setoperone, all tested in the dosage range of .01 to .25 mg/kg and ... These were haloperidol, clopenthixol, tefludazine, and setoperone, all tested in the dosage range of .01 to .25 mg/kg and ...
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Zuclopenthixol1
- Existe incertidumbre sobre el efecto del zuclopenthixol frente a haloperidol en los scores globales de estado mental, el zuclopenthixol no podria no asociarse con eventos adversos evaluados. (bvsalud.org)
Haloperidol2
- Haloperidol clopenthixol and chlorpromazine in chronic schizophrenia" - J. of Nerv. (nih.gov)
- These were haloperidol, clopenthixol, tefludazine, and setoperone, all tested in the dosage range of .01 to .25 mg/kg and compared with saline i.m. once weekly in a random schedule. (elsevier.com)