Clonidine
Adrenergic alpha-2 Receptor Agonists
Yohimbine
Preanesthetic Medication
Receptors, Adrenergic, alpha-2
A subclass of alpha-adrenergic receptors found on both presynaptic and postsynaptic membranes where they signal through Gi-Go G-PROTEINS. While postsynaptic alpha-2 receptors play a traditional role in mediating the effects of ADRENERGIC AGONISTS, the subset of alpha-2 receptors found on presynaptic membranes signal the feedback inhibition of NEUROTRANSMITTER release.
Sympatholytics
Drugs that inhibit the actions of the sympathetic nervous system by any mechanism. The most common of these are the ADRENERGIC ANTAGONISTS and drugs that deplete norepinephrine or reduce the release of transmitters from adrenergic postganglionic terminals (see ADRENERGIC AGENTS). Drugs that act in the central nervous system to reduce sympathetic activity (e.g., centrally acting alpha-2 adrenergic agonists, see ADRENERGIC ALPHA-AGONISTS) are included here.
Adrenergic alpha-Antagonists
Imidazoline Receptors
Receptors, Adrenergic, alpha
One of the two major pharmacological subdivisions of adrenergic receptors that were originally defined by the relative potencies of various adrenergic compounds. The alpha receptors were initially described as excitatory receptors that post-junctionally stimulate SMOOTH MUSCLE contraction. However, further analysis has revealed a more complex picture involving several alpha receptor subtypes and their involvement in feedback regulation.
Guanfacine
Injections, Spinal
Adrenergic alpha-2 Receptor Antagonists
Adjuvants, Anesthesia
Oxymetazoline
Prazosin
Norepinephrine
Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.
Phentolamine
Analgesia, Epidural
Receptors, Adrenergic
Cell-surface proteins that bind epinephrine and/or norepinephrine with high affinity and trigger intracellular changes. The two major classes of adrenergic receptors, alpha and beta, were originally discriminated based on their cellular actions but now are distinguished by their relative affinity for characteristic synthetic ligands. Adrenergic receptors may also be classified according to the subtypes of G-proteins with which they bind; this scheme does not respect the alpha-beta distinction.
Premedication
Dioxanes
Morphine
Double-Blind Method
Dose-Response Relationship, Drug
Anesthetics, Local
Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate.
Hypnotics and Sedatives
Naloxone
Hemodynamics
Neostigmine
Dexmedetomidine
Medetomidine
Methyldopa
Drug Interactions
Sympathetic Nervous System
The thoracolumbar division of the autonomic nervous system. Sympathetic preganglionic fibers originate in neurons of the intermediolateral column of the spinal cord and project to the paravertebral and prevertebral ganglia, which in turn project to target organs. The sympathetic nervous system mediates the body's response to stressful situations, i.e., the fight or flight reactions. It often acts reciprocally to the parasympathetic system.
Epinephrine
The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes systemic VASOCONSTRICTION and gastrointestinal relaxation, stimulates the HEART, and dilates BRONCHI and cerebral vessels. It is used in ASTHMA and CARDIAC FAILURE and to delay absorption of local ANESTHETICS.
Desipramine
A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
Effects of long-term administration of clonidine on plasma renin activity. (1/1378)
Plasma renin activity (PRA) was studied before and during long-term treatment with moderate oral doses (0.2 or 0.3 mg/d) of clonidine. Nine outpatients with essential hypertension received clonidine for 12 weeks; a significant decrease in blood pressure was evident in all patients. Except for a nonsignificant increase after 12 weeks of treatment, PRA values were not notably changed by clonidine therapy. No correlation was found between individual blood pressure changes and PRA variation during the study. The absence of a net effect on PRA in this study does not exclude more complex interactions of clonidine with the renin-angiotensin system. Nonetheless, clonidine cannot generally be classified as a "renin-inhibiting" drug. (+info)Modulation of basal intracellular calcium by inverse agonists and phorbol myristate acetate in rat-1 fibroblasts stably expressing alpha1d-adrenoceptors. (2/1378)
In rat-1 fibroblasts stably expressing alpha1d-adrenoceptors BMY 7378, phentolamine, chloroethylclonidine and 5-methyl urapidil decreased basal [Ca2+]i. WB 4101 induced a very small effect on this parameter but when added before the other antagonists it blocked their effect. All these agents inhibited the action of norepinephrine. Phorbol myristate acetate also blocked the effect of norepinephrine and decreased basal [Ca2+]i. Staurosporine inhibited these effects of the phorbol ester. Our results suggest that: (1) alpha1d-adrenoceptors exhibit spontaneous ligand-independent activity, (2) BMY 7378, phentolamine, chloroethylclonidine and 5-methyl urapidil act as inverse agonists and (3) protein kinase C activation blocks spontaneous and agonist-stimulated alpha1d-adrenoceptor activity. (+info)Spinal antinociceptive synergism between morphine and clonidine persists in mice made acutely or chronically tolerant to morphine. (3/1378)
Morphine (Mor) tolerance has been attributed to a reduction of opioid-adrenergic antinociceptive synergy at the spinal level. The present experiments tested the interaction of intrathecally (i.t.) administered Mor-clonidine (Clon) combinations in mice made acutely or chronically tolerant to Mor. ICR mice were pretreated with Mor either acutely (40 nmol i.t., 8 h; 100 mg/kg s.c., 4 h) or chronically (3 mg/kg s.c. every 6 h days 1 and 2; 5 mg/kg s.c. every 6 h days 3 and 4). Antinociception was detected via the hot water (52.5 degrees C) tail-flick test. After the tail-flick latencies returned to baseline levels, dose-response curves were generated to Mor, Clon, and Mor-Clon combinations in tolerant and control mice. Development of tolerance was confirmed by significant rightward shifts of the Mor dose-response curves in tolerant mice compared with controls. Isobolographic analysis was conducted; the experimental combined ED50 values were compared statistically against their respective theoretical additive ED50 values. In all Mor-pretreated groups, the combination of Mor and Clon resulted in significant leftward shifts in the dose-response curves compared with those of each agonist administered separately. In all tolerant and control groups, the combination of Mor and Clon produced an ED50 value significantly less than the corresponding theoretical additive ED50 value. Mor and Clon synergized in Mor-tolerant as well as in control mice. Spinally administered adrenergic/opioid synergistic combinations may be effective therapeutic strategies to manage pain in patients apparently tolerant to the analgesic effects of Mor. (+info)Altered alpha 1-adrenoceptor subtypes mediated cardiac function after treatment of propranolol to rats. (4/1378)
AIM: To study inotropic and chronotropic effects mediated by alpha 1A- and alpha 1B-adrenoceptors after 5-d propranolol (Pro) treatment. METHODS: The positive inotropic and chronotropic effects mediated by alpha 1A and alpha 1B subtypes were determined on isolated left ventricular papillary muscles and right atrium in Pro- and NaCl-treated rats. RESULTS: The basic contractility of papillary muscles induced by phenylephrine (Phe) was 90 +/- 18 mg in Pro-treated rats and 53 +/- 17 mg in control group (P < 0.05). The increment on force of contraction was 20 +/- 12 mg in Pro-pretreated rats and 5 +/- 5 mg in NaCl-treated rats (P < 0.05). After preincubated with chloroethylclonidine, the increment on force of contraction was reduced in Pro-treated rats, but was not much changed in control group. Phe in presence of 5-methylurapidil induced positive inotropic effect with 13 +/- 5 mg in Pro-treated group, but not in NaCl-treated rats. Under the normal and the inhibited cardiac state, the maximal increment in beat rate mediated by alpha 1B showed no difference between the Pro-treated and NaCl-treated rats. CONCLUSION: After chronic treatment of Pro, alpha 1-adrenoceptor-mediated positive inotropic effect in rat heart was improved, which was mainly induced by stimulation of alpha 1B when beta-adrenoceptors were blocked. (+info)Adrenoceptor agonists inhibit calcium-dependent potentials in rat stellate ganglion neurons. (5/1378)
AIM: To study the effects of adrenoceptor agonists on the stellate ganglion neurons. METHODS: Intracellular recordings were made from neurons of the isolated rat stellate ganglia. RESULTS: Noradrenaline and clonidine (10-30 mumol.L-1) reversibly depressed 3 types of calcium-dependent potentials, namely, the action potential shoulder; the spike after-hyperpolarization; the Ca2+ spike evoked in Krebs' solution containing TTX and TEA and fast excitatory postsynaptic potential (f-EPSP). CONCLUSION: The adrenoceptor agonists inhibitied the 3 calcium-dependent potentials; f-EPSP was inhibited by reducing Ca2+ influx at presynaptic site in population of neurons. (+info)Effects of clonidine on myocardial beta-adrenergic receptor-adenyl cyclase-cAMP system after scalds in rats. (6/1378)
AIM: To study the role of clonidine (Clo) on the myocardial beta-adrenergic receptor (beta-AR)-adenyl cyclase (AC)-cAMP system after the scalds in rats. METHODS: A 30% skin-full-thickness scald was produced by immersing rats in 95 degrees C water for 9 s. Clo 0.1-3.0 mg.kg-1 was injected i.p. to rats at 30 min before scalds, yohimbine (Yoh) 0.05 mg.kg-1 or prazosin (Pra) 0.03 mg.kg-1 to rats at 30 min before i.p. Clo. beta-AR density and affinity, AC activity, phosphoric diester hydrolases (PDH) activity, and cAMP content were determined with radioreceptor assay, indirect method, enzymeradiochemical assay, and radioimmunoassay, respectively. RESULTS: Clo inhibited the decrease of the myocardial beta-AR density, the attenuation of AC activity, and the reduction of cAMP content at 12 h after the scalds. Yoh partially reversed the effects of Clo on the three parameters. But Pra did not. CONCLUSION: Clo reversed the changes of the myocardial beta-AR-AC-cAMP system resulted from the scalds in rats. (+info)Characterization of alpha1-adrenoceptor subtypes mediating vasoconstriction in human umbilical vein. (7/1378)
1. The present study attempted to characterize pharmacologically the subtypes of alpha-adrenoceptors mediating contractions in human umbilical vein (HUV). 2. HUV rings were mounted in isolated organ baths and cumulative concentration-response curves were constructed for the alpha-adrenoceptor agonists phenylephrine and adrenaline. Adrenaline was more potent than phenylephrine (pD2=7.29 and 6.04 respectively). 3. Isoproterenol exhibited no agonism on KCl pre-contracted HUV rings. Propranolol (1 microM) and rauwolscine (0.1 microM) did not affect the concentration-response curves to adrenaline. These results demonstrate the lack of involvement of functional beta-or alpha2-adrenoceptors in adrenaline-induced vasoconstriction. 4. The non subtype selective alpha1-adrenoceptor antagonist prazosin was evaluated on phenylephrine and adrenaline concentration-response curves. The effects of the competitive alpha1A and alpha1D-adrenoceptor antagonists, 5-methyl urapidil and BMY 7378 and the irreversible alpha1B selective compound chloroethylclonidine (CEC) were also evaluated on adrenaline concentration-response curves. 5. The potencies of prazosin against responses mediated by adrenaline (pA2= 10.87) and phenylephrine (pA2= 10.70) indicate the involvement of prazosin-sensitive functional alpha1-adrenoceptor subtype in vasoconstriction of the HUV. 6. The potencies of 5-methyl urapidil (pA2 = 6.70) and BMY 7378 (pA2= 7.34) were not consistent with the activation of an alpha1A- or alpha1D-adrenoceptor population. 7. Exposure to a relatively low CEC concentration (3 microM) abolished the maximum response to adrenaline suggesting that this response was mediated by an alpha1B-adrenoceptor subtype. 8. We conclude that HUV express a prazosin-sensitive functional alpha1-adrenoceptor resembling the alpha1B-subtype according with the low pA2 values for both 5-methyl urapidil and BMY 7378 and the high sensitivity to CEC. (+info)Cardiac baroreflex during the postoperative period in patients with hypertension: effect of clonidine. (8/1378)
BACKGROUND: Patients with essential hypertension show altered baroreflex control of heart rate, and during the perioperative period they demonstrate increased circulatory instability. Clonidine has been shown to reduce perioperative circulatory instability. This study documents changes in measures of heart rate control after surgery in patients with essential hypertension and determines the effects of clonidine on postoperative heart rate control in these patients. METHODS: Using a randomized double-blind placebo-controlled design, 20 patients with essential hypertension (systolic pressure >160 mm Hg or diastolic pressure >95 mm Hg for > or =1 yr) were assigned to receive clonidine (or placebo), 6 microg/kg orally 120 min before anesthesia and 3 microg/kg intravenously over 60 min before the end of surgery. The spontaneous baroreflex ("sequence") technique and analysis of heart rate variability were used to quantify control of heart rate at baseline, before induction of anesthesia, and 1 and 3 h postoperatively. RESULTS: Baroreflex slope and heart rate variability were reduced postoperatively in patients given placebo but not those given clonidine. Clonidine resulted in greater postoperative baroreflex slope and power at all frequency ranges compared with placebo (4.9+/-2.9 vs. 2.2+/-2.1 ms/mm Hg for baroreflex slope, 354+/-685 vs. 30+/-37 ms2/Hz for high frequency variability). Clonidine also resulted in lower concentrations of catecholamine, decreased mean heart rate and blood pressure, and decreased perioperative tachycardia and hypertension. CONCLUSIONS: Patients with hypertension exhibit reduced heart rate control during the recovery period after elective surgery. Clonidine prevents this reduction in heart rate control. This may represent a basis for the improved circulatory stability seen with perioperative administration of clonidine. (+info)
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Lofepramine
Clonidine. Lofepramine may reduce the antihypertensive effects of clonidine. Diazoxide. Enhanced hypotensive (blood pressure- ...
2-Imidazoline
"Clonidine". Pubmed Health. October 2008. Archived from the original on 28 June 2010. Vassilev LT, Vu BT, Graves B, Carvajal D, ... The imidazoline-containing drug clonidine is used alone or in combination with other medications to treat high blood pressure. ... 2-Imidazolines Clonidine Biimidazoline ligands and a complex. Second generation Grubbs' catalyst Spongotine B Cis-imidazolines ...
Mark S. Gold
Clonidine was the first non-opioid medication to reverse acute opioid withdrawal symptoms. He co-authored the dopamine ... "Clonidine , Encyclopedia.com". www.encyclopedia.com. Retrieved 2020-06-23. Gold, MS; Washton, AM; Dackis, CA (1987). "The ... Gold was a lead researcher in the discovery of clonidine's efficacy in opiate withdrawal and a rationale for opiate withdrawal ... Gold, M. S.; Redmond Jr, D. E.; Kleber, H. D. (1978). "Clonidine blocks acute opiate-withdrawal symptoms". The Lancet. 2 (8090 ...
Pheochromocytoma
While the adverse side-effects with clonidine are inconvenient, the most dangerous aspect of clonidine is withdrawal rebound ... Monoamine Oxidase Inhibitors, Clonidine Withdrawal Including but not limited to cocaine use Misuse of over-the-counter ... After fasting overnight, patient's will present to their testing site for a baseline metanephrines blood draw and clonidine ... If the offending medications cannot be discontinued or repeated labs remained the same, consider administering a clonidine ...
Alpha-2 adrenergic receptor
"Methylphenidate and Clonidine Help Children With ADHD and Tics". "Clonidine Oral Uses". Web MD. "EPAR summary for the public: ... clonidine also helps alleviate symptoms of opioid withdrawal. The hypotensive effect of clonidine was initially attributed ... Clonidine has also been successfully used in indications that exceed what would be expected from a simple blood-pressure ... Clonidine is now thought to decrease blood pressure via this central mechanism. Other nonselective agonists include ...
Visceral pain
ketamine, clonidine, gabapentin). In addition, pharmacotherapy that targets the underlying cause of the pain can help alleviate ...
Tolonidine
Clonidine Cosnier, D.; Duchene-Marullaz, P.; Grimal, J.; Rispat, G.; Streichenberger, G. (1975). "Pharmacological properties of ...
Randall-Selitto test
Lal, H.; Fielding, S. (1981). Psychopharmacology of Clonidine. Liss. ISBN 9780845100714. Retrieved 2015-03-24. Randall and ...
Smoking cessation
Clonidine may reduce withdrawal symptoms and "approximately doubles abstinence rates when compared to a placebo", but its side ... Retrieved 2016-07-06.{{cite book}}: CS1 maint: unfit URL (link) Gourlay SG, Stead LF, Benowitz NL (2004). "Clonidine for ...
Secondary hypertension
van Zwieten PA, Thoolen MJ, Timmermans PB (1984). "The hypotensive activity and side effects of methyldopa, clonidine, and ... Lowenstein J (January 1980). "Drugs five years later: clonidine". Annals of Internal Medicine. 92 (1): 74-77. doi:10.7326/0003- ... Medications commonly associated with rebound hypertension include centrally-acting antihypertensive agents, such as clonidine ...
Locus coeruleus
Devenyi P.; Mitwalli A.; Graham W. (November 1982). "Clonidine therapy for narcotic withdrawal". Can Med Assoc J. 127 (10): ... The α2 adrenergic receptor agonist clonidine is used to counteract this withdrawal effect by decreasing adrenergic ...
Attention deficit hyperactivity disorder management
Clonidine An α2A adrenergic receptor agonist has also been approved in the US. Clonidine was initially developed as a treatment ... "clonidine (Rx) - Catapres, Catapres-TTS". Medscape Drugs & Diseases. Rossi, S, ed. (2013). Australian Medicines Handbook (2013 ... Methylphenidate, guanfacine, clonidine, and desipramine were associated with improvement of tic symptoms. Controversy remains, ... Atomoxetine, viloxazine, guanfacine, and clonidine are the only non-controlled, non-stimulant FDA approved drugs for the ...
Management of Tourette syndrome
Clonidine (brand name Catapres) works on tics for about half of people with TS. Maximal benefit may not be achieved for 4-6 ... 1982). "Clonidine in the treatment of Tourette syndrome: a review of data". Advances in Neurology. 35: 391-401. PMID 6756089. ... April 1991). "Clonidine treatment of Gilles de la Tourette's syndrome". Arch. Gen. Psychiatry. 48 (4): 324-8. doi:10.1001/ ... A small number of patients may worsen on clonidine. Guanfacine (brand name Tenex) is another antihypertensive that is used in ...
Outcomes Research Consortium
Aspirin also does not prevent infarctions, while promoting serious surgical bleeding.: Clonidine does not prevent infarctions, ... "Perioperative aspirin and clonidine and risk of acute kidney injury: a randomized clinical trial". JAMA. 312 (21): 2254-64. doi ... "Clonidine in patients undergoing noncardiac surgery". N Engl J Med. 370 (16): 1504-13. doi:10.1056/nejmoa1401106. PMID 24679061 ...
Anxiolytic
Hoehn-Saric, Rudolf; Merchant, A. F.; Keyser, M. L.; Smith, V. K. (1981). "Effects of Clonidine on Anxiety Disorders". Archives ... The Alpha-2 agonists clonidine and guanfacine have demonstrated both anxiolytic and anxiogenic effects. Buspirone (Buspar) is a ...
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... can also be used as an antidote in overdose of clonidine, a medication that lowers blood pressure. Clonidine overdoses ... Seger DL (2002). "Clonidine toxicity revisited". Journal of Toxicology. Clinical Toxicology. 40 (2): 145-155. doi:10.1081/CLT- ... Ahmad SA, Scolnik D, Snehal V, Glatstein M (2015). "Use of naloxone for clonidine intoxication in the pediatric age group: case ... "Poison Alert: Clonidine" (PDF). missouripoisoncenter.org. Missouri Poison Center. Retrieved 10 June 2019. Loden J. "Tennessee ...
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Guanoxabenz Guanfacine Walker BR, Hare LE, Deitch MW (1982). "Comparative antihypertensive effects of guanabenz and clonidine ... "Studies on the mechanism of the central antihypertensive effect of guanabenz and clonidine". Journal of Hypertension Supplement ...
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Hydrochloride13
- Clonidine hydrochloride, USP is a centrally acting alpha-agonist hypotensive agent available as tablets for oral administration in three dosage strengths: 0.1 mg, 0.2 mg, and 0.3 mg. (nih.gov)
- Clonidine hydrochloride, USP is an imidazoline derivative and exists as a mesomeric compound. (nih.gov)
- Clonidine hydrochloride tablets act relatively rapidly. (nih.gov)
- Acute studies with clonidine hydrochloride in humans have demonstrated a moderate reduction (15% to 20%) of cardiac output in the supine position with no change in the peripheral resistance: at a 45 degree tilt there is a smaller reduction in cardiac output and a decrease of peripheral resistance. (nih.gov)
- Clonidine hydrochloride tablets, USP are indicated in the treatment of hypertension. (nih.gov)
- Clonidine hydrochloride tablets may be employed alone or concomitantly with other antihypertensive agents. (nih.gov)
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- In people that completed 5 weeks of therapy in a controlled versatile dosage pediatric adjunctive to stimulants study, 19 % of people treated with clonidine hydrochloride extended-release tablet computers+stimulant vs 8 % treated with inactive medicine+stimulant reported somnolence. (buyclonidine.shop)
- Clonidine hydrochloride may be given by slow intravenous injection over 10 to 15 minutes in hypertensive crises, usually in doses of 150 to 300 micrograms. (epharmacyke.com)
- In the management of severe cancer pain , clonidine hydrochloride may be given by continuous epidural infusion with an opioid, in an initial dose of 30 micrograms/hour, adjusted according to response. (epharmacyke.com)
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Catapres3
- Clonidine tablets (Catapres) are used alone or in combination with other medications to treat high blood pressure. (medlineplus.gov)
- Catapres (Clonidine) is a hypertension medication. (24healthgoods.com)
- Do not use Catapres if you are allergic to clonidine, or if you have recently had a heart attack. (24healthgoods.com)
Tablets5
- Clonidine extended-release tablets may treat ADHD by affecting the part of the brain that controls attention and impulsivity. (medlineplus.gov)
- Clonidine extended-release tablets are available as the brand-name drug Kapvay . (meds-online24.com)
- Clonidine extended-release tablets are used to treat symptoms of attention deficit hyperactivity disorder (ADHD). (meds-online24.com)
- It isn't known exactly how clonidine extended-release tablets work to reduce symptoms of ADHD. (meds-online24.com)
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Kapvay1
- This article aims to summarize the current evidence regarding the use of clonidine extended release (Kapvay™, Shionogi Pharma, GA, USA) in the treatment of children and adolescents with ADHD. (jneuropsychiatry.org)
Hypertension6
- Clonidine may be effective for lowering blood pressure in people with resistant hypertension. (wikipedia.org)
- Clonidine is a centrally acting, α-2 adrenergic agonist used for the treatment of hypertension during pregnancy. (aspetjournals.org)
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ADHD10
- In Australia, clonidine is an accepted but not approved use for ADHD by the TGA. (wikipedia.org)
- Clonidine, along with methylphenidate, has been studied for treatment of ADHD. (wikipedia.org)
- Clonidine has been used to reduce sleep disturbances in ADHD, including to help offset stimulant-associated insomnia. (wikipedia.org)
- Physicians also prescribe clonidine to treat ADHD , though it's less popular for this purpose than psychostimulants. (focuswish.com)
- based on the results, researchers suggest that clonidine may be an effective treatment for sleep disturbances induced by or related to adhd. (morningchurch.com)
- What are the Benefits of Clonidine for ADHD? (sahyogclinic.com)
- As always, the "best" medication (for anything) provides the most symptom control and least si The exact way Clonidine helps to improve ADHD symptoms is unclear. (web.app)
- While clonidine is not usually the first choice of medication for ADHD, it can be helpful for some people in treating ADHD, either alone or combined with another ADHD medication. (web.app)
- It also has a longer half-life than clonidine, which allows for less Guanfacine may help lessen ADHD symptoms such as being disruptive, inattentive, hyperactive, impulsive, and arguing with adults or losing one's temper. (web.app)
- In preclinical This medication may be useful for treating ADHD in children who do not tolerate Clonidine and guanfacine (TenexR, IntunivR) are (-adrenergic agonists. (web.app)
Prescription5
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Medication clonidine1
- Does the blood pressure medication clonidine show up on a urine lab drug test analysis? (drugs.com)
Overdose2
- For those of you who aren't familiar with it, four year-old Rebecca died in 2006 after an overdose of the psychotropic medications clonidine, Depakote, and Seroquel. (thoughtbroadcast.com)
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Antihypertensive2
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Dose8
- Your doctor may start you on a low dose of clonidine and gradually increase your dose, not more than once every week. (medlineplus.gov)
- The pharmacokinetics of clonidine is dose-proportional in the range of 100 to 600 mcg. (nih.gov)
- Clonidine withdrawal can be managed by gradually tapering your dose and avoiding abrupt discontinuation. (focuswish.com)
- This means that after ~14 hour, 50% of your original dose of clonidine remains in your bloodstream, then after a total of ~28 hours, 25% remains, and so on. (focuswish.com)
- Seven of the fourteen patients had subjective symptoms, in three severe enough to require interruption of observation by therapeutic intervention 12 to 60 h after the last dose of clonidine. (focuswish.com)
- Our findings will allow healthcare professionals to pre‐ pare weekly dose of clonidine in glass bottles for storage in a refrigerator. (edu.au)
- The daily required dose of clonidine can be drawn aseptically from the glass bottle each day and stored in a plastic syringe at room temperature. (edu.au)
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Lowers blood pressure2
- Clonidine lowers blood pressure by stimulating α2 receptors in the brain, which results in relaxation of many arteries. (wikipedia.org)
- Clonidine lowers blood pressure by suppressing norepinephrine activity. (focuswish.com)
Pills3
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Micrograms1
- Clonidine may also be given by transdermal delivery systems that are applied once a week and deliver 100 to 300 micrograms of clonidine base daily at a constant rate. (epharmacyke.com)
Tablet2
- Clonidine comes as a tablet and an extended-release (long-acting) tablet to take by mouth. (medlineplus.gov)
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Medications5
- Clonidine is in a class of medications called centrally acting alpha-agonist hypotensive agents. (medlineplus.gov)
- tell your doctor and pharmacist if you are allergic to clonidine, any of its ingredients, clonidine patches, or any other medications. (medlineplus.gov)
- Two of the three medications she was taking (clonidine and valproic acid) are off-patent, so no one can accuse a drug company of "pushing" a medication on Rebecca for the sake of profit. (thoughtbroadcast.com)
- Because newer blood pressure medications have fewer side effects, clonidine is used less today than in the past to treat high blood pressure. (wordpress.com)
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Centrally2
- Clonidine acts centrally by reducing sympathetic tone, resulting in a fall in diastolic and systolic blood pressure and a reduction in heart rate. (nih.gov)
- Clonidine belongs to a class of drugs called centrally acting alpha-agonists. (meds-online24.com)
Tics1
- Clonidine can be used in the treatment of Tourette syndrome (specifically for tics). (wikipedia.org)
Symptoms9
- If you suddenly stop taking clonidine, it can cause a rapid rise in your blood pressure and symptoms such as nervousness, headache, and uncontrollable shaking of a part of the body. (medlineplus.gov)
- Clonidine may improve symptoms of attention deficit hyperactivity disorder in some people but causes many adverse effects and the beneficial effect is modest. (wikipedia.org)
- Clonidine may be used to ease drug withdrawal symptoms associated with abruptly stopping the long-term use of opioids, alcohol, benzodiazepines and nicotine. (wikipedia.org)
- Clonidine has also had some success in clinical trials for helping to remove or ameliorate the symptoms of hallucinogen persisting perception disorder (HPPD). (wikipedia.org)
- Clonidine withdrawal symptoms last 1-2 weeks after stopping the drug. (focuswish.com)
- They are most severe around the 72 hour mark, after which you'll see gradually improvement in clonidine withdrawal symptoms. (focuswish.com)
- Withdrawal symptoms after stopping the daily use of clonidine are common. (focuswish.com)
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Drowsiness1
- Clonidine can cause drowsiness, so it is important to avoid driving or operating heavy machinery until you know how the medication affects you. (24healthgoods.com)
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0.15 mg1
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Pharmacist1
- Read the Patient Information Leaflet if available from your pharmacist before you start taking clonidine and each time you get a refill. (healthwarehouse.com)
Narcotic2
- Clonidine is also used in the treatment of dysmenorrhea (severely painful cramps during menstrual period), hypertensive crisis (a condition in which your blood pressure is very high), Tourette's syndrome (a condition characterized by the need to perform repeated motions or to repeat sounds or words),menopausal hot flashes, and alcohol and opiate (narcotic) withdrawal. (medlineplus.gov)
- Clonidine causes increase of sedative effect of barbiturates, narcotic pain relievers and alcohol. (covid19jipmer.org)
Intravenous1
- Following intravenous administration, clonidine displays biphasic disposition with a distribution half-life of about 20 minutes and an elimination half-life ranging from 12 to 16 hours. (nih.gov)
Pharmaceutical2
- The aim of this study was to investigate the physicochemical stability of clonidine in commonly used pharmaceutical diluents at clinically relevant concentrations and temperatures. (edu.au)
- Certain antidepressants may diminish pharmaceutical effect of Clonidine. (covid19jipmer.org)
Anxiety4
- Clonidine also has several off-label uses, and has been prescribed to treat psychiatric disorders including stress, sleep disorders, hyperarousal caused by post-traumatic stress disorder, borderline personality disorder, and other anxiety disorders. (wikipedia.org)
- If you suspect that you took too much of Clonidine and your blood pressure first becomes too high (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain) and then followed by low blood pressure (fainting, cold feeling, slow heart rate) seek for immediate medical attention. (covid19jipmer.org)
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Transdermal1
- Pharmacokinetic interpretation of the plasma levels of clonidine following transdermal delivery. (cdc.gov)
Opioid withdrawal2
- Clonidine has also been used to treat refractory diarrhea associated with irritable bowel syndrome, fecal incontinence, diabetes, diarrhea associated with opioid withdrawal, intestinal failure, neuroendocrine tumors, and cholera. (wikipedia.org)
- Other uses of clonidine have included the symptomatic treatment of opioid withdrawal, the diagnosis of phaeochromocytoma, and administration as eye drops in the management of glaucoma in Kenya. (epharmacyke.com)
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Pregnancy3
- The major role of CYP2D6 in clonidine metabolism might explain the increase in its nonrenal clearance during pregnancy. (aspetjournals.org)
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Dosage3
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Mechanism of act1
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Doses1
- Therefore, it is important that you do not run out of clonidine or miss any doses. (healthwarehouse.com)
Chronic3
- Clonidine acutely stimulates growth hormone release in both children and adults, but does not produce a chronic elevation of growth hormone with long-term use. (nih.gov)
- IMSEAR at SEARO: Clonidine in chronic simple glaucoma. (who.int)
- The frequency and pathophysiology of the clonidine withdrawal syndrome was studied in fourteen hypertensive patients on chronic clonidine therapy. (focuswish.com)
Acute2
- For example, the potency and efficacy of intrathecal or epidurally administered clonidine increases in patients with neuropathic pain compared to normal subjects with experimental noxious stimuli or patients with acute postoperative pain. (asahq.org)
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Methylphenidate1
- Methylphenidate: May enhance the adverse/toxic effect of CloNIDine. (genericpedia.com)
Flashes1
- Clonidine can also be used for migraine headaches and hot flashes associated with menopause. (wikipedia.org)
Blood vessels2
- Clonidine treats high blood pressure by decreasing your heart rate and relaxing the blood vessels so that blood can flow more easily through the body. (medlineplus.gov)
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Drugs2
- Clonidine may also reduce severity of neonatal abstinence syndrome in infants born to mothers that are using certain drugs, particularly opioids. (wikipedia.org)
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Sedative1
- Clonidine is also a mild sedative, and can be used as premedication before surgery or procedures. (wikipedia.org)
Guanfacine1
- Some studies show clonidine to be more sedating than guanfacine, which may be better at bedtime along with an arousing stimulant in the morning. (wikipedia.org)
Suppression1
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