The process of accumulation of genetic and epigenetic changes over time in individual cells and the effect of the changes on CELL PROLIFERATION.
The process of cumulative change at the level of DNA; RNA; and PROTEINS, over successive generations.
A group of genetically identical cells all descended from a single common ancestral cell by mitosis in eukaryotes or by binary fission in prokaryotes. Clone cells also include populations of recombinant DNA molecules all carrying the same inserted sequence. (From King & Stansfield, Dictionary of Genetics, 4th ed)
Abnormal number or structure of chromosomes. Chromosome aberrations may result in CHROMOSOME DISORDERS.
Clonal hematopoetic disorder caused by an acquired genetic defect in PLURIPOTENT STEM CELLS. It starts in MYELOID CELLS of the bone marrow, invades the blood and then other organs. The condition progresses from a stable, more indolent, chronic phase (LEUKEMIA, MYELOID, CHRONIC PHASE) lasting up to 7 years, to an advanced phase composed of an accelerated phase (LEUKEMIA, MYELOID, ACCELERATED PHASE) and BLAST CRISIS.
Mapping of the KARYOTYPE of a cell.
BENZOIC ACID amides.
GENETIC PHENOMENA characterizing IMMUNITY and the immune response.
An aberrant form of human CHROMOSOME 22 characterized by translocation of the distal end of chromosome 9 from 9q34, to the long arm of chromosome 22 at 22q11. It is present in the bone marrow cells of 80 to 90 per cent of patients with chronic myelocytic leukemia (LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE).
The relationships of groups of organisms as reflected by their genetic makeup.
Clinical conditions caused by an abnormal chromosome constitution in which there is extra or missing chromosome material (either a whole chromosome or a chromosome segment). (from Thompson et al., Genetics in Medicine, 5th ed, p429)
A chronic leukemia characterized by abnormal B-lymphocytes and often generalized lymphadenopathy. In patients presenting predominately with blood and bone marrow involvement it is called chronic lymphocytic leukemia (CLL); in those predominately with enlarged lymph nodes it is called small lymphocytic lymphoma. These terms represent spectrums of the same disease.
A family of 6-membered heterocyclic compounds occurring in nature in a wide variety of forms. They include several nucleic acid constituents (CYTOSINE; THYMINE; and URACIL) and form the basic structure of the barbiturates.
The largest of polypeptide chains comprising immunoglobulins. They contain 450 to 600 amino acid residues per chain, and have molecular weights of 51-72 kDa.
An advanced phase of chronic myelogenous leukemia, characterized by a rapid increase in the proportion of immature white blood cells (blasts) in the blood and bone marrow to greater than 30%.
Examination of CHROMOSOMES to diagnose, classify, screen for, or manage genetic diseases and abnormalities. Following preparation of the sample, KARYOTYPING is performed and/or the specific chromosomes are analyzed.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
A type of IN SITU HYBRIDIZATION in which target sequences are stained with fluorescent dye so their location and size can be determined using fluorescence microscopy. This staining is sufficiently distinct that the hybridization signal can be seen both in metaphase spreads and in interphase nuclei.
Highly proliferative, self-renewing, and colony-forming stem cells which give rise to NEOPLASMS.
Ordered rearrangement of B-lymphocyte variable gene regions of the IMMUNOGLOBULIN HEAVY CHAINS, thereby contributing to antibody diversity. It occurs during the first stage of differentiation of the IMMATURE B-LYMPHOCYTES.
Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
The techniques used to produce molecules exhibiting properties that conform to the demands of the experimenter. These techniques combine methods of generating structural changes with methods of selection. They are also used to examine proposed mechanisms of evolution under in vitro selection conditions.
Retrovirus-associated DNA sequences (abl) originally isolated from the Abelson murine leukemia virus (Ab-MuLV). The proto-oncogene abl (c-abl) codes for a protein that is a member of the tyrosine kinase family. The human c-abl gene is located at 9q34.1 on the long arm of chromosome 9. It is activated by translocation to bcr on chromosome 22 in chronic myelogenous leukemia.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
DNA present in neoplastic tissue.
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
The possession of a third chromosome of any one type in an otherwise diploid cell.
A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements.
Genotypic differences observed among individuals in a population.
Translation products of a fusion gene derived from CHROMOSOMAL TRANSLOCATION of C-ABL GENES to the genetic locus of the breakpoint cluster region gene on chromosome 22. Several different variants of the bcr-abl fusion proteins occur depending upon the precise location of the chromosomal breakpoint. These variants can be associated with distinct subtypes of leukemias such as PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; and NEUTROPHILIC LEUKEMIA, CHRONIC.
A type of chromosome aberration characterized by CHROMOSOME BREAKAGE and transfer of the broken-off portion to another location, often to a different chromosome.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
A leukemia/lymphoma found predominately in children and adolescents and characterized by a high number of lymphoblasts and solid tumor lesions. Frequent sites involve LYMPH NODES, skin, and bones. It most commonly presents as leukemia.
A specific pair of GROUP C CHROMOSOMES of the human chromosome classification.
A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.
A method for comparing two sets of chromosomal DNA by analyzing differences in the copy number and location of specific sequences. It is used to look for large sequence changes such as deletions, duplications, amplifications, or translocations.
The chromosomal constitution of cells which deviate from the normal by the addition or subtraction of CHROMOSOMES, chromosome pairs, or chromosome fragments. In a normally diploid cell (DIPLOIDY) the loss of a chromosome pair is termed nullisomy (symbol: 2N-2), the loss of a single chromosome is MONOSOMY (symbol: 2N-1), the addition of a chromosome pair is tetrasomy (symbol: 2N+2), the addition of a single chromosome is TRISOMY (symbol: 2N+1).
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
That region of the immunoglobulin molecule that varies in its amino acid sequence and composition, and comprises the binding site for a specific antigen. It is located at the N-terminus of the Fab fragment of the immunoglobulin. It includes hypervariable regions (COMPLEMENTARITY DETERMINING REGIONS) and framework regions.
The loss of one allele at a specific locus, caused by a deletion mutation; or loss of a chromosome from a chromosome pair, resulting in abnormal HEMIZYGOSITY. It is detected when heterozygous markers for a locus appear monomorphic because one of the ALLELES was deleted.
Differential and non-random reproduction of different genotypes, operating to alter the gene frequencies within a population.
Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.
The return of a sign, symptom, or disease after a remission.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
Biochemical identification of mutational changes in a nucleotide sequence.
Clonal hematopoietic stem cell disorders characterized by dysplasia in one or more hematopoietic cell lineages. They predominantly affect patients over 60, are considered preleukemic conditions, and have high probability of transformation into ACUTE MYELOID LEUKEMIA.
The complete genetic complement contained in the DNA of a set of CHROMOSOMES in a HUMAN. The length of the human genome is about 3 billion base pairs.
Resistance or diminished response of a neoplasm to an antineoplastic agent in humans, animals, or cell or tissue cultures.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
The developmental history of specific differentiated cell types as traced back to the original STEM CELLS in the embryo.
The continuous developmental process of a culture from simple to complex forms and from homogeneous to heterogeneous qualities.
Theoretical representations that simulate the behavior or activity of genetic processes or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.
The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.
One of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells. In addition to antiviral activity, it activates NATURAL KILLER CELLS and B-LYMPHOCYTES, and down-regulates VASCULAR ENDOTHELIAL GROWTH FACTOR expression through PI-3 KINASE and MAPK KINASES signaling pathways.
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Changes in biological features that help an organism cope with its ENVIRONMENT. These changes include physiological (ADAPTATION, PHYSIOLOGICAL), phenotypic and genetic changes.
Progenitor cells from which all blood cells derive.

Genetic evolution of pancreatic cancer: lessons learnt from the pancreatic cancer genome sequencing project. (1/77)

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Clonal evolution through loss of chromosomes and subsequent polyploidization in chondrosarcoma. (2/77)

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Psychological stress and aging: role of glucocorticoids (GCs). (3/77)

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Silencing, positive selection and parallel evolution: busy history of primate cytochromes C. (4/77)

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Somatic retrotransposition alters the genetic landscape of the human brain. (5/77)

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High order chromatin architecture shapes the landscape of chromosomal alterations in cancer. (6/77)

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Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage. (7/77)

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Unilateral retinitis pigmentosa: a proposal of genetic pathogenic mechanisms. (8/77)

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There are several types of chromosome aberrations, including:

1. Chromosomal deletions: Loss of a portion of a chromosome.
2. Chromosomal duplications: Extra copies of a chromosome or a portion of a chromosome.
3. Chromosomal translocations: A change in the position of a chromosome or a portion of a chromosome.
4. Chromosomal inversions: A reversal of a segment of a chromosome.
5. Chromosomal amplifications: An increase in the number of copies of a particular chromosome or gene.

Chromosome aberrations can be detected through various techniques, such as karyotyping, fluorescence in situ hybridization (FISH), or array comparative genomic hybridization (aCGH). These tests can help identify changes in the chromosomal makeup of cells and provide information about the underlying genetic causes of disease.

Chromosome aberrations are associated with a wide range of diseases, including:

1. Cancer: Chromosome abnormalities are common in cancer cells and can contribute to the development and progression of cancer.
2. Birth defects: Many birth defects are caused by chromosome abnormalities, such as Down syndrome (trisomy 21), which is caused by an extra copy of chromosome 21.
3. Neurological disorders: Chromosome aberrations have been linked to various neurological disorders, including autism and intellectual disability.
4. Immunodeficiency diseases: Some immunodeficiency diseases, such as X-linked severe combined immunodeficiency (SCID), are caused by chromosome abnormalities.
5. Infectious diseases: Chromosome aberrations can increase the risk of infection with certain viruses, such as human immunodeficiency virus (HIV).
6. Ageing: Chromosome aberrations have been linked to the ageing process and may contribute to the development of age-related diseases.
7. Radiation exposure: Exposure to radiation can cause chromosome abnormalities, which can increase the risk of cancer and other diseases.
8. Genetic disorders: Many genetic disorders are caused by chromosome aberrations, such as Turner syndrome (45,X), which is caused by a missing X chromosome.
9. Rare diseases: Chromosome aberrations can cause rare diseases, such as Klinefelter syndrome (47,XXY), which is caused by an extra copy of the X chromosome.
10. Infertility: Chromosome abnormalities can contribute to infertility in both men and women.

Understanding the causes and consequences of chromosome aberrations is important for developing effective treatments and improving human health.

The BCR-ABL gene is a fusion gene that is present in the majority of cases of CML. It is created by the translocation of two genes, called BCR and ABL, which leads to the production of a constitutively active tyrosine kinase protein that promotes the growth and proliferation of abnormal white blood cells.

There are three main phases of CML, each with distinct clinical and laboratory features:

1. Chronic phase: This is the earliest phase of CML, where patients may be asymptomatic or have mild symptoms such as fatigue, night sweats, and splenomegaly (enlargement of the spleen). The peripheral blood count typically shows a high number of blasts in the blood, but the bone marrow is still functional.
2. Accelerated phase: In this phase, the disease progresses to a higher number of blasts in the blood and bone marrow, with evidence of more aggressive disease. Patients may experience symptoms such as fever, weight loss, and pain in the joints or abdomen.
3. Blast phase: This is the most advanced phase of CML, where there is a high number of blasts in the blood and bone marrow, with significant loss of function of the bone marrow. Patients are often symptomatic and may have evidence of spread of the disease to other organs, such as the liver or spleen.

Treatment for CML typically involves targeted therapy with drugs that inhibit the activity of the BCR-ABL protein, such as imatinib (Gleevec), dasatinib (Sprycel), or nilotinib (Tasigna). These drugs can slow or stop the progression of the disease, and may also produce a complete cytogenetic response, which is defined as the absence of all Ph+ metaphases in the bone marrow. However, these drugs are not curative and may have significant side effects. Allogenic hematopoietic stem cell transplantation (HSCT) is also a potential treatment option for CML, but it carries significant risks and is usually reserved for patients who are in the blast phase of the disease or have failed other treatments.

In summary, the clinical course of CML can be divided into three phases based on the number of blasts in the blood and bone marrow, and treatment options vary depending on the phase of the disease. It is important for patients with CML to receive regular monitoring and follow-up care to assess their response to treatment and detect any signs of disease progression.

Synonyms: BCR-ABL fusion gene, t(9;22)(q34;q11), p210 protein, bcr-abl fusion transcript, breakpoint cluster region (BCR) - Abelson tyrosine kinase (ABLE) fusion gene.

Word Origin: Named after the city of Philadelphia, where it was first described in 1960.

There are many different types of chromosome disorders, including:

1. Trisomy: This is a condition in which there is an extra copy of a chromosome. For example, Down syndrome is caused by an extra copy of chromosome 21.
2. Monosomy: This is a condition in which there is a missing copy of a chromosome.
3. Turner syndrome: This is a condition in which there is only one X chromosome instead of two.
4. Klinefelter syndrome: This is a condition in which there are three X chromosomes instead of the typical two.
5. Chromosomal translocations: These are abnormalities in which a piece of one chromosome breaks off and attaches to another chromosome.
6. Inversions: These are abnormalities in which a segment of a chromosome is reversed end-to-end.
7. Deletions: These are abnormalities in which a portion of a chromosome is missing.
8. Duplications: These are abnormalities in which there is an extra copy of a segment of a chromosome.

Chromosome disorders can have a wide range of effects on the body, depending on the type and severity of the condition. Some common features of chromosome disorders include developmental delays, intellectual disability, growth problems, and physical abnormalities such as heart defects or facial anomalies.

There is no cure for chromosome disorders, but treatment and support are available to help manage the symptoms and improve the quality of life for individuals with these conditions. Treatment may include medications, therapies, and surgery, as well as support and resources for families and caregivers.

Preventive measures for chromosome disorders are not currently available, but research is ongoing to understand the causes of these conditions and to develop new treatments and interventions. Early detection and diagnosis can help identify chromosome disorders and provide appropriate support and resources for individuals and families.

In conclusion, chromosome disorders are a group of genetic conditions that affect the structure or number of chromosomes in an individual's cells. These conditions can have a wide range of effects on the body, and there is no cure, but treatment and support are available to help manage symptoms and improve quality of life. Early detection and diagnosis are important for identifying chromosome disorders and providing appropriate support and resources for individuals and families.

In LLCB, the B cells undergo a mutation that causes them to become cancerous and multiply rapidly. This can lead to an overproduction of these cells in the bone marrow, causing the bone marrow to become crowded and unable to produce healthy red blood cells, platelets, and white blood cells.

LLCB is typically a slow-growing cancer, and it can take years for symptoms to develop. However, as the cancer progresses, it can lead to a range of symptoms including fatigue, weakness, weight loss, fever, night sweats, and swollen lymph nodes.

LLCB is typically diagnosed through a combination of physical examination, blood tests, bone marrow biopsy, and imaging studies such as X-rays or CT scans. Treatment options for LLCB include chemotherapy, radiation therapy, and in some cases, stem cell transplantation.

Overall, while LLCB is a serious condition, it is typically slow-growing and can be managed with appropriate treatment. With current treatments, many people with LLCB can achieve long-term remission and a good quality of life.

The term "blast crisis" was first used in the medical literature in 1998 to describe this phenomenon, which was previously known as "accelerated phase." The blast crisis is the most advanced stage of CML and is associated with a poor prognosis if left untreated.

The exact cause of blast crisis is not fully understood, but it is believed to be related to the development of resistance to TKIs, which can lead to an increase in the number of abnormal cells in the bone marrow and blood. The condition typically occurs after several years of TKI therapy, although it can sometimes occur within the first few months of treatment.

The symptoms of blast crisis are non-specific and can include fatigue, fever, night sweats, and weight loss. Laboratory tests will show an elevated white blood cell count, anemia, and thrombocytopenia. The diagnosis of blast crisis is based on the presence of blasts in the blood and bone marrow, as well as other laboratory and radiological findings.

Treatment of blast crisis typically involves the use of more intensive chemotherapy or hematopoietic stem cell transplantation (HSCT). In some cases, the TKI therapy may be discontinued and replaced with a different medication or combination of medications. The prognosis for patients with blast crisis is generally poor, with a five-year survival rate of around 50%. However, with appropriate treatment, some patients can achieve long-term remission or even a cure.

Explanation: Neoplastic cell transformation is a complex process that involves multiple steps and can occur as a result of genetic mutations, environmental factors, or a combination of both. The process typically begins with a series of subtle changes in the DNA of individual cells, which can lead to the loss of normal cellular functions and the acquisition of abnormal growth and reproduction patterns.

Over time, these transformed cells can accumulate further mutations that allow them to survive and proliferate despite adverse conditions. As the transformed cells continue to divide and grow, they can eventually form a tumor, which is a mass of abnormal cells that can invade and damage surrounding tissues.

In some cases, cancer cells can also break away from the primary tumor and travel through the bloodstream or lymphatic system to other parts of the body, where they can establish new tumors. This process, known as metastasis, is a major cause of death in many types of cancer.

It's worth noting that not all transformed cells will become cancerous. Some forms of cellular transformation, such as those that occur during embryonic development or tissue regeneration, are normal and necessary for the proper functioning of the body. However, when these transformations occur in adult tissues, they can be a sign of cancer.

See also: Cancer, Tumor

Word count: 190

Disease progression can be classified into several types based on the pattern of worsening:

1. Chronic progressive disease: In this type, the disease worsens steadily over time, with a gradual increase in symptoms and decline in function. Examples include rheumatoid arthritis, osteoarthritis, and Parkinson's disease.
2. Acute progressive disease: This type of disease worsens rapidly over a short period, often followed by periods of stability. Examples include sepsis, acute myocardial infarction (heart attack), and stroke.
3. Cyclical disease: In this type, the disease follows a cycle of worsening and improvement, with periodic exacerbations and remissions. Examples include multiple sclerosis, lupus, and rheumatoid arthritis.
4. Recurrent disease: This type is characterized by episodes of worsening followed by periods of recovery. Examples include migraine headaches, asthma, and appendicitis.
5. Catastrophic disease: In this type, the disease progresses rapidly and unpredictably, with a poor prognosis. Examples include cancer, AIDS, and organ failure.

Disease progression can be influenced by various factors, including:

1. Genetics: Some diseases are inherited and may have a predetermined course of progression.
2. Lifestyle: Factors such as smoking, lack of exercise, and poor diet can contribute to disease progression.
3. Environmental factors: Exposure to toxins, allergens, and other environmental stressors can influence disease progression.
4. Medical treatment: The effectiveness of medical treatment can impact disease progression, either by slowing or halting the disease process or by causing unintended side effects.
5. Co-morbidities: The presence of multiple diseases or conditions can interact and affect each other's progression.

Understanding the type and factors influencing disease progression is essential for developing effective treatment plans and improving patient outcomes.

Trisomy is caused by an extra copy of a chromosome, which can be due to one of three mechanisms:

1. Trisomy 21 (Down syndrome): This is the most common type of trisomy and occurs when there is an extra copy of chromosome 21. It is estimated to occur in about 1 in every 700 births.
2. Trisomy 13 (Patau syndrome): This type of trisomy occurs when there is an extra copy of chromosome 13. It is estimated to occur in about 1 in every 10,000 births.
3. Trisomy 18 (Edwards syndrome): This type of trisomy occurs when there is an extra copy of chromosome 18. It is estimated to occur in about 1 in every 2,500 births.

The symptoms of trisomy can vary depending on the type of trisomy and the severity of the condition. Some common symptoms include:

* Delayed physical growth and development
* Intellectual disability
* Distinctive facial features, such as a flat nose, small ears, and a wide, short face
* Heart defects
* Vision and hearing problems
* GI issues
* Increased risk of infection

Trisomy can be diagnosed before birth through prenatal testing, such as chorionic villus sampling (CVS) or amniocentesis. After birth, it can be diagnosed through a blood test or by analyzing the child's DNA.

There is no cure for trisomy, but treatment and support are available to help manage the symptoms and improve the quality of life for individuals with the condition. This may include physical therapy, speech therapy, occupational therapy, and medication to manage heart defects or other medical issues. In some cases, surgery may be necessary to correct physical abnormalities.

The prognosis for trisomy varies depending on the type of trisomy and the severity of the condition. Some forms of trisomy are more severe and can be life-threatening, while others may have a more mild impact on the individual's quality of life. With appropriate medical care and support, many individuals with trisomy can lead fulfilling lives.

In summary, trisomy is a genetic condition that occurs when there is an extra copy of a chromosome. It can cause a range of symptoms and can be diagnosed before or after birth. While there is no cure for trisomy, treatment and support are available to help manage the symptoms and improve the quality of life for individuals with the condition.

Symptoms of aplastic anemia may include fatigue, weakness, shortness of breath, pale skin, and increased risk of bleeding or infection. Treatment options for aplastic anemia typically involve blood transfusions and immunosuppressive drugs to stimulate the bone marrow to produce new blood cells. In severe cases, a bone marrow transplant may be necessary.

Overall, aplastic anemia is a rare and serious condition that requires careful management by a healthcare provider to prevent complications and improve quality of life.

https://www.medicinenet.com › Medical Dictionary › G

A genetic translocation is a change in the number or arrangement of the chromosomes in a cell. It occurs when a portion of one chromosome breaks off and attaches to another chromosome. This can result in a gain or loss of genetic material, which can have significant effects on the individual.

Genetic Translocation | Definition & Facts | Britannica
https://www.britannica.com › science › Genetic-tr...

Genetic translocation, also called chromosomal translocation, a type of chromosomal aberration in which a portion of one chromosome breaks off and attaches to another chromosome. This can result in a gain or loss of genetic material. Genetic translocations are often found in cancer cells and may play a role in the development and progression of cancer.

Translocation, Genetic | health Encyclopedia - UPMC
https://www.upmc.com › health-library › gene...

A genetic translocation is a change in the number or arrangement of the chromosomes in a cell. It occurs when a portion of one chromosome breaks off and attaches to another chromosome. This can result in a gain or loss of genetic material, which can have significant effects on the individual.

Genetic Translocation | Genetics Home Reference - NIH
https://ghr.nlm.nih.gov › condition › ge...

A genetic translocation is a change in the number or arrangement of the chromosomes in a cell. It occurs when a portion of one chromosome breaks off and attaches to another chromosome. This can result in a gain or loss of genetic material, which can have significant effects on the individual.

In conclusion, Genetic Translocation is an abnormality in the number or arrangement of chromosomes in a cell. It occurs when a portion of one chromosome breaks off and attaches to another chromosome, resulting in a gain or loss of genetic material that can have significant effects on the individual.

The symptoms of PRE-B-ALL can include fever, fatigue, night sweats, weight loss, and swollen lymph nodes. The cancer can also spread to other parts of the body, such as the central nervous system, spleen, and bones.

PRE-B-ALL is most commonly seen in children, but it can also occur in adults. It is a rare cancer, accounting for only about 5% of all childhood leukemias and less than 1% of all adult leukemias.

The exact cause of PRE-B-ALL is not known, but it is believed to be linked to genetic mutations that occur during fetal development or early childhood. Some risk factors that may increase the likelihood of developing PRE-B-ALL include:

1. Genetic disorders, such as Down syndrome or Fanconi anemia.
2. Exposure to radiation or certain chemicals during pregnancy or early childhood.
3. Infections, such as HIV or Epstein-Barr virus.
4. Family history of PRE-B-ALL or other blood cancers.

To diagnose PRE-B-ALL, a bone marrow biopsy and aspiration are typically performed to collect a sample of cells for analysis. Additional tests, such as flow cytometry, immunophenotyping, and cytogenetic analysis, may also be conducted to confirm the diagnosis and identify any specific genetic abnormalities.

Treatment for PRE-B-ALL usually involves a combination of chemotherapy and/or bone marrow transplantation. The prognosis for PRE-B-ALL varies depending on the patient's age, overall health, and the specific genetic abnormalities present in the cancer cells. With current treatments, the 5-year survival rate for PRE-B-ALL is approximately 70-80%. However, the disease can sometimes relapse, and patients may require ongoing monitoring and treatment to prevent relapse and manage any long-term complications.

There are several types of aneuploidy, including:

1. Trisomy: This is the presence of an extra copy of a chromosome. For example, Down syndrome is caused by an extra copy of chromosome 21 (trisomy 21).
2. Monosomy: This is the absence of a chromosome.
3. Mosaicism: This is the presence of both normal and abnormal cells in the body.
4. Uniparental disomy: This is the presence of two copies of a chromosome from one parent, rather than one copy each from both parents.

Aneuploidy can occur due to various factors such as errors during cell division, exposure to certain chemicals or radiation, or inheritance of an abnormal number of chromosomes from one's parents. The risk of aneuploidy increases with age, especially for women over the age of 35, as their eggs are more prone to errors during meiosis (the process by which egg cells are produced).

Aneuploidy can be diagnosed through various methods such as karyotyping (examining chromosomes under a microscope), fluorescence in situ hybridization (FISH) or quantitative PCR. Treatment for aneuploidy depends on the underlying cause and the specific health problems it has caused. In some cases, treatment may involve managing symptoms, while in others, it may involve correcting the genetic abnormality itself.

In summary, aneuploidy is a condition where there is an abnormal number of chromosomes present in a cell, which can lead to various developmental and health problems. It can occur due to various factors and can be diagnosed through different methods. Treatment depends on the underlying cause and the specific health problems it has caused.

AML is a fast-growing and aggressive form of leukemia that can spread to other parts of the body through the bloodstream. It is most commonly seen in adults over the age of 60, but it can also occur in children.

There are several subtypes of AML, including:

1. Acute promyelocytic leukemia (APL): This is a subtype of AML that is characterized by the presence of a specific genetic abnormality called the PML-RARA fusion gene. It is usually responsive to treatment with chemotherapy and has a good prognosis.
2. Acute myeloid leukemia, not otherwise specified (NOS): This is the most common subtype of AML and does not have any specific genetic abnormalities. It can be more difficult to treat and has a poorer prognosis than other subtypes.
3. Chronic myelomonocytic leukemia (CMML): This is a subtype of AML that is characterized by the presence of too many immature white blood cells called monocytes in the blood and bone marrow. It can progress slowly over time and may require ongoing treatment.
4. Juvenile myeloid leukemia (JMML): This is a rare subtype of AML that occurs in children under the age of 18. It is characterized by the presence of too many immature white blood cells called blasts in the blood and bone marrow.

The symptoms of AML can vary depending on the subtype and the severity of the disease, but they may include:

* Fatigue
* Weakness
* Shortness of breath
* Pale skin
* Easy bruising or bleeding
* Swollen lymph nodes, liver, or spleen
* Bone pain
* Headache
* Confusion or seizures

AML is diagnosed through a combination of physical examination, medical history, and diagnostic tests such as:

1. Complete blood count (CBC): This test measures the number and types of cells in the blood, including red blood cells, white blood cells, and platelets.
2. Bone marrow biopsy: This test involves removing a small sample of bone marrow tissue from the hipbone or breastbone to examine under a microscope for signs of leukemia cells.
3. Genetic testing: This test can help identify specific genetic abnormalities that are associated with AML.
4. Immunophenotyping: This test uses antibodies to identify the surface proteins on leukemia cells, which can help diagnose the subtype of AML.
5. Cytogenetics: This test involves staining the bone marrow cells with dyes to look for specific changes in the chromosomes that are associated with AML.

Treatment for AML typically involves a combination of chemotherapy, targeted therapy, and in some cases, bone marrow transplantation. The specific treatment plan will depend on the subtype of AML, the patient's age and overall health, and other factors. Some common treatments for AML include:

1. Chemotherapy: This involves using drugs to kill cancer cells. The most commonly used chemotherapy drugs for AML are cytarabine (Ara-C) and anthracyclines such as daunorubicin (DaunoXome) and idarubicin (Idamycin).
2. Targeted therapy: This involves using drugs that specifically target the genetic abnormalities that are causing the cancer. Examples of targeted therapies used for AML include midostaurin (Rydapt) and gilteritinib (Xospata).
3. Bone marrow transplantation: This involves replacing the diseased bone marrow with healthy bone marrow from a donor. This is typically done after high-dose chemotherapy to destroy the cancer cells.
4. Supportive care: This includes treatments to manage symptoms and side effects of the disease and its treatment, such as anemia, infection, and bleeding. Examples of supportive care for AML include blood transfusions, antibiotics, and platelet transfusions.
5. Clinical trials: These are research studies that involve testing new treatments for AML. Participating in a clinical trial may give patients access to innovative therapies that are not yet widely available.

It's important to note that the treatment plan for AML is highly individualized, and the specific treatments used will depend on the patient's age, overall health, and other factors. Patients should work closely with their healthcare team to determine the best course of treatment for their specific needs.

Recurrence can also refer to the re-emergence of symptoms in a previously treated condition, such as a chronic pain condition that returns after a period of remission.

In medical research, recurrence is often studied to understand the underlying causes of disease progression and to develop new treatments and interventions to prevent or delay its return.

There are several subtypes of MDS, each with distinct clinical features and prognosis. The most common subtype is refractory anemia with excess blasts (RAEB), followed by chronic myelomonocytic leukemia (CMMoL) and acute myeloid leukemia (AML).

The exact cause of MDS is not fully understood, but it is believed to result from a combination of genetic mutations and environmental factors. Risk factors for developing MDS include exposure to certain chemicals or radiation, age over 60, and a history of previous cancer treatment.

Symptoms of MDS can vary depending on the specific subtype and severity of the disorder, but may include fatigue, weakness, shortness of breath, infection, bleeding, and easy bruising. Diagnosis is typically made through a combination of physical examination, medical history, blood tests, and bone marrow biopsy.

Treatment for MDS depends on the specific subtype and severity of the disorder, as well as the patient's overall health and preferences. Options may include supportive care, such as blood transfusions and antibiotics, or more intensive therapies like chemotherapy, bone marrow transplantation, or gene therapy.

Overall, myelodysplastic syndromes are a complex and heterogeneous group of disorders that can have a significant impact on quality of life and survival. Ongoing research is focused on improving diagnostic accuracy, developing more effective treatments, and exploring novel therapeutic approaches to improve outcomes for patients with MDS.

Neoplasm refers to an abnormal growth of cells that can be benign (non-cancerous) or malignant (cancerous). Neoplasms can occur in any part of the body and can affect various organs and tissues. The term "neoplasm" is often used interchangeably with "tumor," but while all tumors are neoplasms, not all neoplasms are tumors.

Types of Neoplasms

There are many different types of neoplasms, including:

1. Carcinomas: These are malignant tumors that arise in the epithelial cells lining organs and glands. Examples include breast cancer, lung cancer, and colon cancer.
2. Sarcomas: These are malignant tumors that arise in connective tissue, such as bone, cartilage, and fat. Examples include osteosarcoma (bone cancer) and soft tissue sarcoma.
3. Lymphomas: These are cancers of the immune system, specifically affecting the lymph nodes and other lymphoid tissues. Examples include Hodgkin lymphoma and non-Hodgkin lymphoma.
4. Leukemias: These are cancers of the blood and bone marrow that affect the white blood cells. Examples include acute myeloid leukemia (AML) and chronic lymphocytic leukemia (CLL).
5. Melanomas: These are malignant tumors that arise in the pigment-producing cells called melanocytes. Examples include skin melanoma and eye melanoma.

Causes and Risk Factors of Neoplasms

The exact causes of neoplasms are not fully understood, but there are several known risk factors that can increase the likelihood of developing a neoplasm. These include:

1. Genetic predisposition: Some people may be born with genetic mutations that increase their risk of developing certain types of neoplasms.
2. Environmental factors: Exposure to certain environmental toxins, such as radiation and certain chemicals, can increase the risk of developing a neoplasm.
3. Infection: Some neoplasms are caused by viruses or bacteria. For example, human papillomavirus (HPV) is a common cause of cervical cancer.
4. Lifestyle factors: Factors such as smoking, excessive alcohol consumption, and a poor diet can increase the risk of developing certain types of neoplasms.
5. Family history: A person's risk of developing a neoplasm may be higher if they have a family history of the condition.

Signs and Symptoms of Neoplasms

The signs and symptoms of neoplasms can vary depending on the type of cancer and where it is located in the body. Some common signs and symptoms include:

1. Unusual lumps or swelling
2. Pain
3. Fatigue
4. Weight loss
5. Change in bowel or bladder habits
6. Unexplained bleeding
7. Coughing up blood
8. Hoarseness or a persistent cough
9. Changes in appetite or digestion
10. Skin changes, such as a new mole or a change in the size or color of an existing mole.

Diagnosis and Treatment of Neoplasms

The diagnosis of a neoplasm usually involves a combination of physical examination, imaging tests (such as X-rays, CT scans, or MRI scans), and biopsy. A biopsy involves removing a small sample of tissue from the suspected tumor and examining it under a microscope for cancer cells.

The treatment of neoplasms depends on the type, size, location, and stage of the cancer, as well as the patient's overall health. Some common treatments include:

1. Surgery: Removing the tumor and surrounding tissue can be an effective way to treat many types of cancer.
2. Chemotherapy: Using drugs to kill cancer cells can be effective for some types of cancer, especially if the cancer has spread to other parts of the body.
3. Radiation therapy: Using high-energy radiation to kill cancer cells can be effective for some types of cancer, especially if the cancer is located in a specific area of the body.
4. Immunotherapy: Boosting the body's immune system to fight cancer can be an effective treatment for some types of cancer.
5. Targeted therapy: Using drugs or other substances to target specific molecules on cancer cells can be an effective treatment for some types of cancer.

Prevention of Neoplasms

While it is not always possible to prevent neoplasms, there are several steps that can reduce the risk of developing cancer. These include:

1. Avoiding exposure to known carcinogens (such as tobacco smoke and radiation)
2. Maintaining a healthy diet and lifestyle
3. Getting regular exercise
4. Not smoking or using tobacco products
5. Limiting alcohol consumption
6. Getting vaccinated against certain viruses that are associated with cancer (such as human papillomavirus, or HPV)
7. Participating in screening programs for early detection of cancer (such as mammograms for breast cancer and colonoscopies for colon cancer)
8. Avoiding excessive exposure to sunlight and using protective measures such as sunscreen and hats to prevent skin cancer.

It's important to note that not all cancers can be prevented, and some may be caused by factors that are not yet understood or cannot be controlled. However, by taking these steps, individuals can reduce their risk of developing cancer and improve their overall health and well-being.

"Clonal evolution of preleukemic hematopoietic stem cells precedes human acute myeloid leukemia". Science Translational Medicine ... "Clonal evolution in myelodysplastic syndromes". Nature Communications. 8: 15099. Bibcode:2017NatCo...815099D. doi:10.1038/ ... as having Clonal Hematopoiesis of Indeterminate Potential (CHIP). A clonal involvement (sometimes referred to simply as the ... of the population over age 70 has observable clonal hematopoiesis. Having clonal hematopoiesis has been linked to a more than ...
This allows evolution to proceed more rapidly, a phenomenon known as the Hill-Robertson effect. On the contrary, in asexually ... Clonal interference does not only play a role in the fixation of mutations in chromosomal DNA, but it also influences the ... The phenomenon of clonal interference also occurs in cancer and pre-cancer cell lineages within a patient. The heterogeneity ... The idea of clonal interference was introduced by American geneticist Hermann Joseph Muller in 1932. It explains why beneficial ...
Greaves M, Maley CC (January 2012). "Clonal evolution in cancer". Nature. 481 (7381): 306-313. Bibcode:2012Natur.481..306G. doi ... Evolutionary therapy relies on the notion that Darwinian evolution is the main reason behind lethality of late stage cancer and ... Card KJ, LaBar T, Gomez JB, Lenski RE (October 2019). "Historical contingency in the evolution of antibiotic resistance after ... These obstacles include high contingency of trajectory, speed of evolution, and inability to track the population state of ...
Some clonal types disappeared entirely. Meanwhile, sexual snail populations remained much more stable over time. However, ... It is probable that the evolution of sex was an integral part of the evolution of the first eukaryotic cell. There are a few ... Ridley, Mark (2003). Evolution (3rd ed.). Wiley. p. 314. ISBN 9781405103459. Beukeboom, L. & Perrin, N. (2014). The Evolution ... Hoekstra, Rolf F. (1987). "The Evolution of Sexes". In Stearns, Stephen C. (ed.). The Evolution of Sex and its Consequences. ...
Loxdale HD, Lushai G. (2003) Rapid changes in clonal lines: the death of a 'sacred cow'. Biological Journal of the Linnean ... Loxdale HD (2009) What's in a clone: the rapid evolution of aphid asexual lineages in relation to geography, host plant ... Loxdale has written reviews on absence of strict genetic uniformity in populations of clonal organisms such as aphids. This ... These include the migration and dispersal of insects in relation to their genotype and habitat; intra-clonal genetic variation ...
Among the clonal population of these aphids, there may be several distinct morphs and this lays the foundation for a possible ... Chen, Rui; Wang, Zhe; Chen, Jing; Jiang, Li-Yun; Qiao, Ge-Xia (2017). "Insect-bacteria parallel evolution in multiple-co- ... However, there are differences between these sexual social insects and the clonal aphids, which are all descended from a single ... Eggs are parthenogenetically produced without meiosis and the offspring are clonal to their mother, so they are all female ( ...
... better known as the somatic evolution model. The clonal evolution model, which occurs in both the CSC model and stochastic ... According to the "stochastic model" (or "clonal evolution model") every cancer cell in a tumor could gain the ability to self- ... 4). These two models are not mutually exclusive, as CSCs themselves undergo clonal evolution. Thus, the secondary more dominant ... Nowell PC (October 1976). "The clonal evolution of tumor cell populations". Science. 194 (4260): 23-8. Bibcode:1976Sci...194... ...
... there is an involvement of multiple cycles of clonal and non-clonal expansion. Even at the typical clonal expansion phase, ... focusing on research in evolution in cancer and somatic evolution Carlo Maley's lab, focusing on research in evolution in ... Cancer stem cell arises by clonal evolution as a result of selection for the cell with the highest fitness in the neoplasm. ... de Grouchy J, de Nava C, Cantu JM, Bilski-Pasquier G, Bousser J (September 1966). "Models for clonal evolutions: a study of ...
Thus, the process of carcinogenesis is formally a process of Darwinian evolution, known as somatic or clonal evolution. ... Nowell, Peter C. (1 October 1976). "The Clonal Evolution of Tumor Cell Populations: Acquired genetic lability permits stepwise ... Nowell PC (October 1976). "The clonal evolution of tumor cell populations". Science. 194 (4260): 23-8. Bibcode:1976Sci...194... ... Just as a population of animals undergoes evolution, an unchecked population of cells also can undergo "evolution". This ...
The clonal evolution model was first proposed in 1976 by Peter Nowell. In this model, tumours arise from a single mutated cell ... These are the cancer stem cell model and the clonal evolution model. The models are not mutually exclusive, and it is believed ... Stem cell variability is often caused by epigenetic changes, but can also result from clonal evolution of the CSC population ... This has been suggested as a reliable method for tracking clonal evolution. However, this technique proves challenging in ...
... termed clonal evolution, drives progression towards more invasive stages. Clonal evolution leads to intra-tumour heterogeneity ... Murgia C, Pritchard JK, Kim SY, Fassati A, Weiss RA (August 2006). "Clonal origin and evolution of a transmissible cancer". ... This rebellion-like scenario is an undesirable survival of the fittest, where the driving forces of evolution work against the ... Cancers usually arise from an assemblage of mutations and epimutations that confer a selective advantage leading to clonal ...
Murgia C, Pritchard JK, Kim SY, Fassati A, Weiss RA (August 2006). "Clonal origin and evolution of a transmissible cancer". ... Rebbeck CA, Thomas R, Breen M, Leroi AM, Burt A (September 2009). "Origins and evolution of a transmissible cancer". Evolution ... The evolution of transmissible cancer is unlikely, because the cell clone must be adapted to survive a physical transmission of ... The evolution of transmissible cancer has occurred naturally in other animal species, but human cancer transmission is rare. In ...
"Dynamic evolution of clonal epialleles revealed by methclone". Genome Biology. 15 (9): 472. doi:10.1186/s13059-014-0472-5. ISSN ...
Murgia, C; Pritchard JK; Kim SY; Fassati A; Weiss RA (2006-08-11). "Clonal Origin and Evolution of a Transmissible Cancer". ... Rebbeck CA, Thomas R, Breen M, Leroi AM, Burt A (2009). "Origins and Evolution of a Transmissible Cancer". Evolution. 63 (9): ... Belov, Katherine; Jones, Elizabeth; Cheng, Yuanyuan (September 2015). "The origin, dynamics, and molecular evolution of ...
Clonal origin and evolution of a transmissible cancer. Cell. 2006 Aug 11;126(3):477-87. Gomez-Raya L, Olsen HG, Lingaas F, ...
Given this insignificant level of clonal mixing, there is a low chance for barriers to the evolution and propagation of an ... the researchers were able to examine the degree of clonal mixing in the colony. Clonal mixing is defined as the "mixing" of ... So, the researchers concluded that the aphids do not adapt to short-term changes in the colony via a reduction of clonal mixing ... However, further studies on colonies where the level of clonal mixing is predicted to be high would enable researchers to gain ...
"Clonal genome evolution and rapid invasive spread of the marbled crayfish". Nature Ecology & Evolution. 2 (3): 567-573. doi: ...
"Clonal genome evolution and rapid invasive spread of the marbled crayfish". Nature Ecology & Evolution. 2 (3): 567-573. doi: ... "Clonal genome evolution and rapid invasive spread of the marbled crayfish". Nature Ecology & Evolution. 2 (3): 567-573. doi: ... Günter Vogt (2010). "Suitability of the clonal marbled crayfish for biogerontological research: A review and perspective, with ... Development Genes and Evolution. 216 (4): 169-184. doi:10.1007/s00427-005-0041-8. PMID 16389558. S2CID 17494732. ...
January 2012). "Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing". Nature. 481 (7382): ... A big contribution to cancer death and failed cancer treatment is clonal evolution at the cytogenetic level, for example as ... 2010). "Evolution of an adenocarcinoma in response to selection by targeted kinase inhibitors". Genome Biology. 11 (8): R82. ... October 2009). "Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution". Nature. 461 (7265): ...
McGovern, Tamara N. (2002). "Sex-ratio bias and clonal reproduction in the brittle star Ophiactis savignyi". Evolution. 56 (3 ...
"The dynamics of adaptive genetic diversity during the early stages of clonal evolution". Nature Ecology & Evolution. 3 (2): 293 ... Desai, Michael M; Fisher, Daniel S; Murray, Andrew W (March 2007). "The speed of evolution and maintenance of variation in ... Tikhonov, Mikhail; Kachru, Shamit; Fisher, Daniel S (2019). "Modeling the interplay between plastic tradeoffs and evolution in ... Fisher, Daniel S (January 2013). "Asexual evolution waves: fluctuations and universality". J. Stat. Mech.: Theory Exp. 2013 (1 ...
2012). "Clonal evolution in relapsed acute myeloid leukemia revealed by whole-genome sequencing". Nature. 481 (7382): 506-10. ...
However, this fast evolution might also be due to these sequences' inability to repair DNA damage via template-assisted repair ... April 2018). "Clonal polymorphism and high heterozygosity in the celibate genome of the Amazon molly". Nature Ecology & ... Evolution of sexual reproduction Genetic hitchhiking Hill-Robertson effect Muller HJ (1932). "Some genetic aspects of sex". ... original paper as cited by, e.g.: Smith JM, Szathmary E (1997). The major transitions in evolution. Oxford, New York, Tokyo: ...
... clonal evolution or a phenotypic mimic?". Human Pathology. 32 (10): 1102-1108. doi:10.1053/hupa.2001.28252. PMID 11679945. ... will eventually develop the rhabdoid phenotype during tumor evolution and progression. In one large series of 902 surgically ...
Bardelli's team tweaked the clonal evolution of the tumour, via a pharmacological intervention, to provoke the persistent ... "Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients". Nature Medicine. 21 (7): 795-801 ... molecular heterogeneity and clonal evolution, both inter-patient and intra-tumour, to overcome the resistance to targeted ... One of the main focuses of his research is the study of the emergence and evolution of drug-resistant clones that can be ...
"Genetic heterogeneity and clonal evolution underlying development of asynchronous metastasis in human breast cancer". Cancer ... This explains the concept of tumour heterogeneity and the order of genetic events during tumor evolution. Many of the genes ... The genetic profiles of primary and metastatic lesions in breast carcinomas show a large extent of clonal pertinence between ... "Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution". Nature. 461 (7265): 809-13. Bibcode: ...
Evolution; International Journal of Organic Evolution. 46 (6): 1935-1944. doi:10.1111/j.1558-5646.1992.tb01179.x. ISSN 1558- ... Avise, John C. (2015-07-21). "Evolutionary perspectives on clonal reproduction in vertebrate animals". Proceedings of the ... Schlupp, Ingo (2005). "The Evolutionary Ecology of Gynogenesis". Annual Review of Ecology, Evolution, and Systematics. 36: 399- ... Evolution. 34 (5): 917-922. doi:10.2307/2407997. hdl:2027.42/137459. ISSN 0014-3820. JSTOR 2407997. PMID 28581138. (Wikipedia ...
... and diploid LR females generate clonal LL and clonal R gametes respectively, instead of recombined L and clonal LR. P. lessonae ... The genetics, ecology, and evolution of sexual abstinence in vertebrate animals. New York, Oxford University Press: i-xi + 1- ... esculentus (genotype RL) exclude here the P. ridibundus (R) or P. lessonae (L) genome in a 3:1 ratio and make mainly clonal P. ... esculentus (genotype RL) exclude here the P. lessonae genome (L) and make exclusively clonal P. ridibundus gametes (R). In ...
"Complex spatial clonal structure in the macroalgae Fucus radicans with both sexual and asexual recruitment". Ecology and ... Evolution. 5 (19): 4233-4245. doi:10.1002/ece3.1629. PMC 4667831. PMID 26664675. "BAMBI, Baltic Sea Marine Biodiversity". ...
El-Kebir M, Oesper L, Acheson-Field H, Raphael BJ (June 2015). "Reconstruction of clonal trees and tumor composition from multi ... Paradis E, Claude J, Strimmer K (January 2004). "APE: Analyses of Phylogenetics and Evolution in R language". Bioinformatics. ... Molecular Biology and Evolution. 23 (2): 254-67. doi:10.1093/molbev/msj030. PMID 16221896. Jobb G, von Haeseler A, Strimmer K ( ... Molecular Biology and Evolution. 29 (8): 1969-1973. doi:10.1093/molbev/mss075. PMC 3408070. PMID 22367748. Jiang Y, Qiu Y, Minn ...
945-. ISBN 978-0-12-200400-1. Hughes, D.J. (1992). "Genotype-environment interactions and relative clonal fitness in a marine ... Andrey N. Ostrovsky (16 December 2013). Evolution of Sexual Reproduction in Marine Invertebrates: Example of gymnolaemate ...
Early domestication of animals, such as cats and dogs, in Africa led to a later evolution of host-specific fungus, Microsporum ... Gräser, Y; De Hoog, S; Summerbell, RC (2006). "Dermatophytes: recognizing species of clonal fungi". Medical Mycology. 44 (3): ... Genetics and Evolution. 4 (3): 179-186. doi:10.1016/j.meegid.2003.12.004. PMID 15450196. Summerbell, Richard C. "What is the ...
Both species, and their hybrid, can form large clonal colonies, forming dense mats that hold organic matter in place on rock ... Haufler, Christopher H.; Windham, Michael D.; Rabe, Eric W. (1995). "Reticulate Evolution in the Polypodium vulgare Complex". ...
Zbinden, M.; Haag, C. R.; Ebert, D. (2008-07-01). "Experimental evolution of field populations of Daphnia magna in response to ... "Single-nucleotide polymorphisms of two closely related microsporidian parasites suggest a clonal population expansion after the ... Altermatt, F.; Hottinger, F.W. & D. Ebert (2007). "Parasites promote host gene flow in a metapopulation" (PDF). Evolution ... Ebert, D. (2005). Ecology, epidemiology and evolution of parasitism in Daphnia. Bethesda (MD): National Library of Medicine (US ...
ln clonal populations of Paramecium, aging occurs over successive generations leading to a gradual loss of vitality, unless the ... Unity, diversity and evolution. London: Taylor and Francis, pp. 361-390, p. 362, [1]. "Balantidiasis". DPDx - Laboratory ... The basis for clonal aging was clarified by the transplantation experiments of Aufderheide in 1986 who demonstrated that the ... Additional experiments by Smith-Sonneborn, Holmes and Holmes, and Gilley and Blackburn demonstrated that, during clonal aging, ...
Lokki, Juhani; Esko Suomalainen; Anssi Saura; Pekka Lankinen (1975-03-01). "Genetic Polymorphism and Evolution in ... Engelstädter, Jan (2017). "Asexual but Not Clonal: Evolutionary Processes in Automictic Populations , Genetics". Genetics. 206 ...
Clonal populations of bacteria, each population maintaining a single artificial chromosome, are stored in various laboratories ... FISH can be used to study the evolution of chromosomes. Species that are related have similar chromosomes. This homology can be ... Eukaryotic chromosome fine structure G banding Gene mapping Genome evolution Happy mapping In situ hybridization, the technique ...
USDA/ARS National Clonal Germplasm Repository. Archived from the original on 2012-09-26. Retrieved 2013-03-09. Sharon Angella ... Nowak, Martin A.; Boerlijst, Maarten C.; Cooke, Jonathan; Smith, John Maynard (1997). "Evolution of genetic redundancy". Nature ...
Marra made fundamental contributions to that effort by devising and then implementing clonal fingerprinting techniques that led ... "Evolution of an adenocarcinoma in response to selection by targeted kinase inhibitors". Genome Biology. 11 (8): R82. doi: ...
shift in the CD4+/CD8+ ratio the accumulation and clonal expansion of memory and effector T cells impaired development of CD4+ ... and harmful agents early in life and in adulthood become detrimental late in life in a period largely not foreseen by evolution ... granzyme B or perforin impaired proliferation in response to antigenic stimulation accumulation and clonal expansion of memory ...
D. magna has become a model system to study the evolution and ecology of host-parasite interaction. Animals collected from ... This form of reproduction is characterised by the alternating production of asexual offspring (clonal reproduction) and at ... D. magna is used in different field of research, such as ecotoxicology, population genetics, the evolution of sex, phenotypic ... Little, T. J.; Chadwick, W.; Watt, K. (2008-03-01). "Parasite variation and the evolution of virulence in a Daphnia- ...
As a result, mtDNA become clonal copies of each other, except when a new mutation arises. As a result, mtDNA does not have ... In defining the rate of evolution in the anchor one has the problem that random mutation creates. For example, a rate of .005 ... See Causes of Error) In 1979, W.M.Brown and Wilson began looking at the evolution of mitochondrial DNA in animals, and found ... At the time, however Ayala was not aware of rapid evolution of HLA loci via recombinatory process. In 1996, Parham and Ohta ...
... including IL-2 pro-inflammatory cytokine secretion and IL-2-dependent clonal expansion of T cells. Upon T-cell receptor (TCR) ... and highly conserved throughout evolution (amino acids 5-68 for human EFS). SH3 domains bind to proline-rich motif containing ...
Davies R, Conroy SJ, Davies WL, Potter IC, Trezise AE (19-23 June 2005). "Evolution and Regulation of the Cystic Fibrosis Gene ... Cell engineering methods including fluorogenic oligonucleotide signaling probes may be used to detect and isolate clonal cell ... Molecular Biology and Evolution. 25 (9): 1795-1808. doi:10.1093/molbev/msn104. PMC 2515873. PMID 18453548. "The Clinical and ... " (conference paper). Molecular Biology and Evolution (MBE05) Conference. Retrieved 28 July 2014. "Genetics and CF". The Cystic ...
Arnold, M. L. (1997). Natural Hybridization and Evolution. New York: Oxford University Press. ISBN 0-19-509974-5. Conte, L.; ... a clonal colony of Quercus palmeri or Palmer's oak found in Riverside County, California - is an estimated 13,000 years old. ... Lepidobalanus (Endl.) Oerst.) in Slovakia estimated by allozymes". Plant Systematics and Evolution. 266 (3-4): 253-264. doi: ... and the evolution of new species. Frequent hybridization and high levels of introgression have caused different species in the ...
Although fitness penalties are common in resistance evolution many MBC resistant pathogens do not suffer any penalty and a few ... Arango Isaza, R. E. (2016). "Combating a Global Threat to a Clonal Crop: Banana Black Sigatoka Pathogen Pseudocercospora ... Hawkins, N.J.; Fraaije, B.A. (2018-08-25). "Fitness Penalties in the Evolution of Fungicide Resistance". Annual Review of ...
Leffler CT, Schwartz SG, Stackhouse R, Davenport B, Spetzler K (December 2013). "Evolution and impact of eye and vision terms ... and cellular stress is normally suppressed by myeloid suppression while inducible Treg cells prevent activation and clonal ...
As an ex situ conservation technique tissue culture is primary used for clonal propagation of vegetative tissue or immature ... preserving it under semi-isolated conditions whereby natural evolution and adaptation processes are either temporarily halted ... This allows for the proliferation of clonal plants from a relatively small amount of parent tissue. Endangered animal species ...
Genome Biology and Evolution. Oxford University Press (Society for Molecular Biology & Evolution). 13 (2). doi:10.1093/gbe/ ... Status of Rubus germplasm at the US National Clonal Germplasm Repository in Corvallis, Oregon. XII International Rubus and ... Mayrose, Itay; Lysak, Martin A (2020). "The Evolution of Chromosome Numbers: Mechanistic Models and Experimental Approaches". ...
Les, D.H., Cleland, M.A. and Waycott, M. (1997) "Phylogenetic studies in Alismatidae, II: evolution of marine angiosperms ( ... "Implications of Extreme Life Span in Clonal Organisms: Millenary Clones in Meadows of the Threatened Seagrass Posidonia ... Zilber-Rosenberg, I. and Rosenberg, E. (2008) "Role of microorganisms in the evolution of animals and plants: the hologenome ... Rosenberg, E. and Zilber-Rosenberg, I. (2016) "Microbes drive evolution of animals and plants: the hologenome concept". MBio, 7 ...
Janeway CA, Jr (1 November 2013). "Pillars article: approaching the asymptote? Evolution and revolution in immunology. Cold ... a process known as clonal selection. In most cases, an antibody can only react to and bind one specific antigen; in some ...
This led them to conclude that the tumour cells in different animals were of the same clonal origin. As a result, they proposed ... "Evolution of a contagious cancer: epigenetic variation in Devil Facial Tumour Disease". Proceedings of the Royal Society B: ...
This is the only group of trees of their period known to have a clonal habit. This type of asexual reproduction would allow ... Stewart, W. N. Paleobotany and the Evolution of Plants. Cambridge University Press, Cambridge (1983). Davis, Paul and Kenrick, ... Evolution of horsetails (Equisetales) within the major euphyllophyte clade Sphenopsida". American Journal of Botany. 105 (8): ...
This group includes S. equi, which causes strangles in horses, and S. zooepidemicus-S. equi is a clonal descendant or biovar of ... Genetics and Evolution. 66: 130-151. doi:10.1016/j.meegid.2018.09.020. ISSN 1567-1348. PMID 30248475. S2CID 52813184. Xu, P; ... Genetics and Evolution. 66: 130-151. doi:10.1016/j.meegid.2018.09.020. ISSN 1567-1348. PMID 30248475. S2CID 52813184. Patel, ...
"Clonal evolution and genome stability in a 2,500-year-old fungal individual", bioRxiv, Cold Spring Harbor Laboratory: 377234, ... Using genotyping and clonal analysis, scientists determined that a 2500-year old specimen of Armillaria ostoyae in northern ... Korhonen, K. (1978). "Interfertility and Clonal Size in Armillaria mellea Complex". Karstenia. 18: 31-42. doi:10.29203/ka. ...
... such as the evolution symbiotic or pathogenic interactions, and the evolution of different morphologies. Major chromosomal ... In the extremely halotolerant black yeast Hortaea werneckii it was discovered that while the species is clonal, both haploid ... The comparison of fungal genomes has been used to study the evolution of fungi, to improve the resolution of the phylogeny of ... Hane JK, Rouxel T, Howlett BJ, Kema GH, Goodwin SB, Oliver RP (2011-05-24). "A novel mode of chromosomal evolution peculiar to ...
... of the somatic mutations found in mutator phenotype human colorectal tumors occur before the onset of terminal clonal expansion ... the damage detection and repair systems are as complex as the replication machinery itself highlights the importance evolution ...
Despite the various possible fates of the radial glial population, it has been demonstrated through clonal analysis that most ... Since upper cortical layers have expanded greatly in recent evolution, and are associated with higher-level information ... Rakic P (October 2009). "Evolution of the neocortex: a perspective from developmental biology". Nature Reviews. Neuroscience. ... processing and thinking, radial glia have been implicated as important mediators of brain evolution. The best characterized and ...
Clonal Fragmentation in multicellular or colonial organisms is a form of asexual reproduction or cloning where an organism is ... Bernstein, H.; Hopf, F.A.; Michod, R.E. (1987). "The molecular basis of the evolution of sex". Adv. Genet. Advances in Genetics ... In these examples, all the individuals are clones, and the clonal population may cover a large area. Many multicellular ... van der Kooi, C. J.; Schwander, T. (2014). "Evolution of asexuality via different mechanisms in grass thrips (Thysanoptera: ...
All MeSH CategoriesPhenomena and Processes CategoryCell Physiological PhenomenaClonal EvolutionClonal Hematopoiesis ... All MeSH CategoriesPhenomena and Processes CategoryGenetic PhenomenaClonal EvolutionClonal Hematopoiesis ... Clonal Evolution. The process of accumulation of genetic and epigenetic changes over time in individual cells and the effect of ...
Clonal evolution of glioblastoma under therapy Jiguang Wang 1 2 , Emanuela Cazzato 3 , Erik Ladewig 1 2 , Veronique Frattini 4 ... Clonal evolution of glioblastoma under therapy Jiguang Wang et al. Nat Genet. 2016 Jul. ... Molecular and clonal evolution in vivo reveal a common pathway of distant relapse gliomas. Liu G, Bu C, Guo G, Zhang Z, Sheng Z ... Figure 3. Mathematical model of tumor evolution (A) Moduli space of GBM evolution trees. Each ball represents one patient, and ...
Tumor heterogeneity and evolution drive treatment resistance in metastatic colorectal cancer (mCRC). Patient-derived xenografts ...
Evolution of Sequence Type 4821 Clonal Complex Hyperinvasive and Quinolone-Resistant Meningococci Mingliang Chen1. , Odile B. ... Evolution of Sequence Type 4821 Clonal Complex Hyperinvasive and Quinolone-Resistant Meningococci. ... Phylogenetic tree and data of clonal complex 4821 Neisseria meningitidis sublineage L44.1 (ChinaCC4821-R1-C/B) isolates. Red ...
Clonal evolution was categorized as high-risk (overt myeloid neoplasm [meeting WHO criteria … ... C) CI for development of all clonal evolution when baseline ANC >0.87×109/L and (D) for high-risk clonal evolution when ... Figure 2:. Overall survival after clonal evolution or HSCT, and cumulative incidence of clonal evolution with eltrombopag (A) ... Figure 2:. Overall survival after clonal evolution or HSCT, and cumulative incidence of clonal evolution… ...
However, clonal evolution is highly dynamic and a minor clone in KO40D cells may become the dominant clone in KO90D cells. ... 2921 Single-Cell Transcriptomics of Human TET2 Knockout CD4 T-Cells and Their Clonal Evolution Program: Oral and Poster ... Whole transcriptome sequencing and single-cell transcriptome sequencing were used to study the cell evolution after KO. ...
Clonal evolution and genomic diversification of Bordetella hinzii in an immunocompromised host. Wednesday, September 12, 2018. ... Here we describe extensive adaptive evolution of B. hinzii in a patient with recessive germline IL-12Rβ1 deficiency who ... Comparative analyses demonstrated that all isolates were clonal, but had undergone extensive genomic diversification. ... in the immunocompromised host may yield novel insights into the immunobiology of pathogen host-jumps and intra-host evolution. ...
Here, the authors infer the clonal hierarchy of 1809 MDS patients, revealing insights into the evolution of dominant/secondary ... The clonal hierarchy has distinct ranking and the resultant invariant combinations of dominant/secondary mutations yield novel ... All 3,971 mutations are grouped based on their rank in the deduced clonal hierarchy (dominant and secondary). We evaluated how ... Here, analyzing 1809 MDS patients, we infer clonal architecture by using a stringent, the single-cell sequencing validated ...
Clonal evolution and hierarchy in myeloid malignancies. Takahashi, Koichi; Tanaka, Tomoyuki. Afiliação *Takahashi K; Department ... In this review, we delve into the intricacies of clonal evolution in myeloid malignancies and its implications for the ... Recent advancements in clonal hematopoiesis research and the use of cutting-edge single cell technologies have shed new light ... Clonal evolution and hierarchy in myeloid malignancies. ... Evolução Clonal/genética clonal evolution; mutation order; ...
A Clonal Evolution Study has been published in PLoS Medicine! This work was co-led by Robert Kridel and Fong Chun Chan and ... illuminates the contrasting modes of evolution shaping the clinical histories of transformation and progression with ... Faculty of Medicine » Home » Histological Transformation and Progression in Follicular Lymphoma: A Clonal Evolution Study ... Histological Transformation and Progression in Follicular Lymphoma: A Clonal Evolution Study. By stacy hung on April 13, 2017 ...
The clonal nature of hiPSC lines allows a high-resolution … ... Clonal Evolution* * DNA Copy Number Variations* * Fibroblasts ... The clonal nature of hiPSC lines allows a high-resolution analysis of the genomes of the founder fibroblast cells without being ... Finally, AF distribution of mosaic SNVs had distinct narrow peaks, which could be a characteristic of clonal cell selection, ... clonal expansion, or both. These findings reveal a large degree of somatic mosaicism in healthy human tissues, link de novo and ...
OR clonal evolution [mh]. OR clonal evolution [tw]. OR colonography, computed tomographic. OR colonoscopy. OR colposcopy. OR ...
Prospective Study of Clonal Evolution in Follicular Lymphoma. This study is currently recruiting participants. ...
c-Kit M541L variant is related to ineffective hemopoiesis predisposing to clonal evolution in 3D in vitro biomimetic co-culture ...
Malignant clonal evolution from high proportion of monocytes in patients with aplastic anemia: a case report ...
How does this spatial structure interact with adaptive evolution? We consider a simple model of a spatially-extended, adapting ... Abstract: H35.00003 : Adapting populations in space: clonal interference and genetic diversity. 2:54 PM-3:06 PM ... population and show that, while clonal interference severely limits the adaptation of purely asexual populations, even rare ...
The Clonal Evolution of Metastatic Osteosarcoma as Shaped by Cisplatin Treatment. Mol Cancer Res 2019. doi: 10.1158/1541-7786. ... Ma X, Zhang K, Li X. Evolution of Drosophila ribosomal protein gene core promoters. Gene 432:54-9, 2009. ...
Presentation: Bone Marrow Failures; Aplastic Anemia and Clonal Evolution: Germline and Somatic Genetics. Presenters: Akiko ...
Clonal evolution of chemotherapy-resistant urothelial carcinoma. Nat. Genet. 2016, 48, 1490-1499. [Google Scholar] [CrossRef] [ ... Paired Exome Analysis Reveals Clonal Evolution and Potential Therapeutic Targets in Urothelial Carcinoma. Cancer Res. 2016, 76 ... as well as a pathogenetic mechanism of clonal evolution [98,102,103]. In this setting, whole-slide imaging and software ...
We have performed various simulations of clonal and partially clonal populations. We introduce allelic dropouts and null ... This is especially critical in clonal organisms in which deviation from panmixia, as measured by Wrights FIS, can, in ... We use the narrow relationship that links Wrights FIS to genetic diversity in purely clonal populations as assessment ... The application of this method to reinterpret published data sets of pathogenic clonal microbes (yeast and trypanosomes) ...
Genomic Studies of Clonal Evolution in Bone Marrow Failure. Akiko Shimamura, M.D., Ph.D.. 11:15 a.m. - 11:30 a.m.. ...
"Clonal evolution represents a central feature of tumor progression and relapse. Chronic lymphocytic leukemia (CLL) is a ... To directly test these ideas, I will systematically examine the clonal dynamics of a cohort of 17 CLL patients that were ... intratumoral genetic heterogeneity in CLL and have linked the presence of aggressive subclonal mutations with clonal evolution ...
ARS Home » Pacific West Area » Corvallis, Oregon » National Clonal Germplasm Repository » People » Nahla Bassil ... Target capture sequencing unravels Rubus evolution. -(Peer Reviewed Journal) Carter, K.A., Liston, A., Bassil, N.V., Alice, L.A ... Confirming clonal identity: A case study in blueberries. -(Peer Reviewed Journal) Hummer, K.E., Bassil, N.V. 2023. Confirming ... Mentha L. and Pycnanthemum L. germplasm at the US National Clonal Germplasm Repository in Corvallis, Oregon. -(Book / Chapter) ...
Intratumor DNA Methylation Heterogeneity Reflects Clonal Evolution in Aggressive Prostate Cancer Brocks D., Assenov Y., Minner ... In order to reconstruct the clonal evolution of histomorphological patterns, we performed global DNA methylation profiling of ... Intratumor DNA methylation heterogeneity demonstrated a branched clonal evolution of ADC regions driven by genomic instability ... Sebe-Pedros A., Chomsky E., Pang K. et_al. (2018) Nature ecology & evolution. 2, 7, p. 1176-+ Abstract A hallmark of metazoan ...
Mechanisms of clonal evolution in somatic tissues with age: The hematopoietic system and the skin have been shown to exhibit ... The mechanisms leading to clonal dominance and their importance for cancer promotion or inhibition are poorly understood. ... these pathways can affect the evolution of cancer. Such studies could lead to the design of interventions to reduce cancer risk ... the aging hematopoietic system plays a role in the evolution/progression of solid tumors and cardiovascular diseases. The aging ...
Clonal evolution in cancer Maley, Carlo C. (2011) Overlooking evolution : a systematic analysis of cancer relapse and ... Greaves, M. and C. C. Maley (2012). Clonal evolution in cancer. Nature 481: 306-313. doi: 10.1038/nature10762. Merlo, L. M., ... My plan is to write a graduate-level textbook on Evolution and Cancer. The field of evolution and cancer currently lacks a ... Cancer in light of experimental evolution Maley, Carlo C. (2012) Natural resistance to cancers : a Darwinian hypothesis to ...
Evolution and Conservation hosted by the University of Lausanne ... Evolution of the population of the Arctic Char in Lake Geneva. ... Behaviour, Economics and Evolution specialisation. First-steps project:. Behavior and lifespan in a clonal ant ... You are here: UNIL , School of biology , Master of Science in Behaviour, Evolution and Conservation , Our students , Former ...
  • While strong driver hits result in MDS instantly in form of a de novo disease, some of the founder mutations in MDS originate from subclinical clonal expansions, referred to as clonal hematopoiesis (CH) present in the blood of some otherwise healthy individuals 18 , 19 . (nature.com)
  • Recent advancements in clonal hematopoiesis research and the use of cutting-edge single cell technologies have shed new light on the developmental process of myeloid malignancies . (bvsalud.org)
  • Our work on the Histological Transformation and Progression in Follicular Lymphoma: A Clonal Evolution Study has been published in PLoS Medicine! (ubc.ca)
  • Clonal evolution and hierarchy in myeloid malignancies. (bvsalud.org)
  • In this review , we delve into the intricacies of clonal evolution in myeloid malignancies and its implications for the development of new diagnostic and therapeutic approaches . (bvsalud.org)
  • Here we describe extensive adaptive evolution of B. hinzii in a patient with recessive germline IL-12Rβ1 deficiency who presented with chronic bloodstream and gastrointestinal tract infection. (nih.gov)
  • Irrespective of origins, MDS pathogenesis includes initial ancestral lesion followed by the stepwise acquisition of subsequent somatic mutations resulting in a highly diverse clonal hierarchy 17 . (nature.com)
  • In particular, I am interested in methods to slow somatic evolution for cancer prevention and to delay, prevent, or target the evolution of therapeutic resistance in malignant neoplasms. (wiko-berlin.de)
  • All 3,971 mutations are grouped based on their rank in the deduced clonal hierarchy (dominant and secondary). (nature.com)
  • The clonal hierarchy has distinct ranking and the resultant invariant combinations of dominant/secondary mutations yield novel insights into the specific clinical phenotype of MDS. (nature.com)
  • Here, analyzing 1809 MDS patients, we infer clonal architecture by using a stringent, the single-cell sequencing validated PyClone bioanalytic pipeline, and assess the position of the mutations within the clonal architecture. (nature.com)
  • Recent large-scale sequencing studies have identified putative driver genetic events of CLL, uncovered the vast inter-personal and intratumoral genetic heterogeneity in CLL and have linked the presence of aggressive subclonal mutations with clonal evolution and poorer outcome. (europa.eu)
  • The evolution of drug resistance in HIV occurs by the fixation of specific, well-known, drug-resistance mutations, but the underlying population genetic processes are not well understood. (harvard.edu)
  • The adaptive landscape analogy has found practical use in recent years, as many have explored how their understanding can inform therapeutic strategies that subvert the evolution of drug resistance. (harvard.edu)
  • We consider a simple model of a spatially-extended, adapting population and show that, while clonal interference severely limits the adaptation of purely asexual populations, even rare recombination is enough to allow adaptation at rates approaching those of well-mixed populations. (aps.org)
  • We use the narrow relationship that links Wright's F IS to genetic diversity in purely clonal populations as assessment criterion, since this relationship disappears faster with sexual recombination than with amplification problems of certain alleles. (biomedcentral.com)
  • We have performed various simulations of clonal and partially clonal populations. (biomedcentral.com)
  • How does this spatial structure interact with adaptive evolution? (aps.org)
  • Adaptive evolution by natural selection is the primary force shaping biological diversity. (harvard.edu)
  • The application of this method to reinterpret published data sets of pathogenic clonal microbes (yeast and trypanosomes) confirms its usefulness and allows refining previous estimates concerning important pathogenic agents. (biomedcentral.com)
  • The clonal nature of hiPSC lines allows a high-resolution analysis of the genomes of the founder fibroblast cells without being confounded by the artifacts of single-cell whole-genome amplification. (nih.gov)
  • This pauses the evolution of new and diverse B cells that could potentially beat back new virus variants. (nih.gov)
  • Finally, AF distribution of mosaic SNVs had distinct narrow peaks, which could be a characteristic of clonal cell selection, clonal expansion, or both. (nih.gov)
  • Late relapse in acute myeloid leukemia (AML): clonal evolution or therapy-related leukemia? (nature.com)
  • Clonal evolution represents a central feature of tumor progression and relapse. (europa.eu)
  • This work was co-led by Robert Kridel and Fong Chun Chan and illuminates the contrasting modes of evolution shaping the clinical histories of transformation and progression with implications in the context of treatment-induced selective pressures. (ubc.ca)
  • Whole transcriptome sequencing and single-cell transcriptome sequencing were used to study the cell evolution after KO. (confex.com)
  • 9. Clonal evolution in diffuse large B-cell lymphoma with central nervous system recurrence. (nih.gov)
  • Spatially divergent clonal evolution in multiple myeloma: overcoming resistance to BRAF inhibition. (uni-heidelberg.de)
  • The clonal evolution of metastatic colorectal cancer. (osu.edu)
  • My plan is to write a graduate-level textbook on Evolution and Cancer. (wiko-berlin.de)
  • The field of evolution and cancer currently lacks a textbook that summarizes the field and identifies the open questions and promising avenues for research. (wiko-berlin.de)
  • Thus, writing the book will benefit greatly from regular discussions with other evolutionary biologists and ecologists in residence at the Wissenschaftskolleg and specifically from discussions with the Cancer Evolution focus group. (wiko-berlin.de)
  • In the process of writing the textbook, I propose to develop a vision of which experiments and projects in the evolution of cancer are both feasible and likely to have a large impact on the management of prevention of cancer. (wiko-berlin.de)
  • This will form the basis of a large collaborative grant proposal to help fund our Center for Evolution and Cancer at UCSF. (wiko-berlin.de)
  • Clonal evolution in cancer. (wiko-berlin.de)
  • Study of established zoonotic infections in the immunocompromised host may yield novel insights into the immunobiology of pathogen host-jumps and intra-host evolution. (nih.gov)
  • Confirming clonal identity: A case study in blueberries. (usda.gov)
  • This is especially critical in clonal organisms in which deviation from panmixia, as measured by Wright's F IS , can, in principle, be used to infer both the extent of clonality and structure in a given population. (biomedcentral.com)
  • To directly test these ideas, I will systematically examine the clonal dynamics of a cohort of 17 CLL patients that were recurrently sampled over years from diagnosis until the time of first treatment. (europa.eu)
  • Phylogenetic tree and data of clonal complex 4821 Neisseria meningitidis sublineage L44.1 (China CC4821-R1-C/B ) isolates. (cdc.gov)
  • We introduce allelic dropouts and null alleles in clonal data sets and compare the results with those that exhibit increasing rates of sexual recombination. (biomedcentral.com)
  • Dr. Nahla Victor Bassil is a Molecular Plant Geneticist with the United States Department of Agriculture (USDA) - Agricultural Research Service (ARS) - National Clonal Germplasm Repository (NCGR) in Corvallis, Oregon. (usda.gov)
  • Phylogenetic tree and data of clonal complex 4821 Neisseria meningitidis sublineage L44.1 (China CC4821-R1-C/B ) isolates. (cdc.gov)
  • Expansion of quinolone-resistant Neisseria meningitidis clone China CC4821-R1-C/B from sequence type (ST) 4821 clonal complex (CC4821) caused a serogroup shift from serogroup A to serogroup C invasive meningococcal disease (IMD) in China. (cdc.gov)
  • In China, the national dissemination of hyperinvasive sequence type (ST) 4821 clonal complex (CC4821) meningococci led to a shift in IMD epidemiology from mostly MenA to predominantly MenC ( 3 , 4 ). (cdc.gov)
  • Comparative analyses demonstrated that all isolates were clonal, but had undergone extensive genomic diversification. (nih.gov)
  • genetic relationships among isolates are defined by clonal complexes (CCs) identified by multilocus sequence typing (MLST), which are surrogates for lineages ( 2 ). (cdc.gov)