Clonal Evolution
Evolution, Molecular
Clone Cells
A group of genetically identical cells all descended from a single common ancestral cell by mitosis in eukaryotes or by binary fission in prokaryotes. Clone cells also include populations of recombinant DNA molecules all carrying the same inserted sequence. (From King & Stansfield, Dictionary of Genetics, 4th ed)
Chromosome Aberrations
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Clonal hematopoetic disorder caused by an acquired genetic defect in PLURIPOTENT STEM CELLS. It starts in MYELOID CELLS of the bone marrow, invades the blood and then other organs. The condition progresses from a stable, more indolent, chronic phase (LEUKEMIA, MYELOID, CHRONIC PHASE) lasting up to 7 years, to an advanced phase composed of an accelerated phase (LEUKEMIA, MYELOID, ACCELERATED PHASE) and BLAST CRISIS.
Philadelphia Chromosome
An aberrant form of human CHROMOSOME 22 characterized by translocation of the distal end of chromosome 9 from 9q34, to the long arm of chromosome 22 at 22q11. It is present in the bone marrow cells of 80 to 90 per cent of patients with chronic myelocytic leukemia (LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE).
Chromosome Disorders
Leukemia, Lymphocytic, Chronic, B-Cell
A chronic leukemia characterized by abnormal B-lymphocytes and often generalized lymphadenopathy. In patients presenting predominately with blood and bone marrow involvement it is called chronic lymphocytic leukemia (CLL); in those predominately with enlarged lymph nodes it is called small lymphocytic lymphoma. These terms represent spectrums of the same disease.
Pyrimidines
Immunoglobulin Heavy Chains
Blast Crisis
Cytogenetic Analysis
Mutation
In Situ Hybridization, Fluorescence
Neoplastic Stem Cells
Gene Rearrangement, B-Lymphocyte, Heavy Chain
Cell Transformation, Neoplastic
Directed Molecular Evolution
The techniques used to produce molecules exhibiting properties that conform to the demands of the experimenter. These techniques combine methods of generating structural changes with methods of selection. They are also used to examine proposed mechanisms of evolution under in vitro selection conditions.
Genes, abl
Retrovirus-associated DNA sequences (abl) originally isolated from the Abelson murine leukemia virus (Ab-MuLV). The proto-oncogene abl (c-abl) codes for a protein that is a member of the tyrosine kinase family. The human c-abl gene is located at 9q34.1 on the long arm of chromosome 9. It is activated by translocation to bcr on chromosome 22 in chronic myelogenous leukemia.
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Disease Progression
Anemia, Aplastic
Fusion Proteins, bcr-abl
Translation products of a fusion gene derived from CHROMOSOMAL TRANSLOCATION of C-ABL GENES to the genetic locus of the breakpoint cluster region gene on chromosome 22. Several different variants of the bcr-abl fusion proteins occur depending upon the precise location of the chromosomal breakpoint. These variants can be associated with distinct subtypes of leukemias such as PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; and NEUTROPHILIC LEUKEMIA, CHRONIC.
Translocation, Genetic
Base Sequence
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
Chromosomes, Human, Pair 8
Sequence Analysis, DNA
Comparative Genomic Hybridization
Aneuploidy
The chromosomal constitution of cells which deviate from the normal by the addition or subtraction of CHROMOSOMES, chromosome pairs, or chromosome fragments. In a normally diploid cell (DIPLOIDY) the loss of a chromosome pair is termed nullisomy (symbol: 2N-2), the loss of a single chromosome is MONOSOMY (symbol: 2N-1), the addition of a chromosome pair is tetrasomy (symbol: 2N+2), the addition of a single chromosome is TRISOMY (symbol: 2N+1).
Polymerase Chain Reaction
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Phenotype
Immunoglobulin Variable Region
That region of the immunoglobulin molecule that varies in its amino acid sequence and composition, and comprises the binding site for a specific antigen. It is located at the N-terminus of the Fab fragment of the immunoglobulin. It includes hypervariable regions (COMPLEMENTARITY DETERMINING REGIONS) and framework regions.
Loss of Heterozygosity
Selection, Genetic
Leukemia, Myeloid, Acute
Models, Biological
Myelodysplastic Syndromes
Genome, Human
Drug Resistance, Neoplasm
Prognosis
Cell Lineage
Cultural Evolution
Models, Genetic
Bone Marrow
The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.
Interferon-alpha
One of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells. In addition to antiviral activity, it activates NATURAL KILLER CELLS and B-LYMPHOCYTES, and down-regulates VASCULAR ENDOTHELIAL GROWTH FACTOR expression through PI-3 KINASE and MAPK KINASES signaling pathways.
Species Specificity
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
Neoplasms
Survival Analysis
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
Stem Cells
Amino Acid Sequence
Adaptation, Biological
Genetic evolution of pancreatic cancer: lessons learnt from the pancreatic cancer genome sequencing project. (1/77)
(+info)Clonal evolution through loss of chromosomes and subsequent polyploidization in chondrosarcoma. (2/77)
(+info)Psychological stress and aging: role of glucocorticoids (GCs). (3/77)
(+info)Silencing, positive selection and parallel evolution: busy history of primate cytochromes C. (4/77)
(+info)Somatic retrotransposition alters the genetic landscape of the human brain. (5/77)
(+info)High order chromatin architecture shapes the landscape of chromosomal alterations in cancer. (6/77)
(+info)Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage. (7/77)
(+info)Unilateral retinitis pigmentosa: a proposal of genetic pathogenic mechanisms. (8/77)
(+info)
Cancer Attractors And Phenotype Plasticity In Non-Darwinian Somatic Evolution Of Drug Resistance
MixClone: a mixture model for inferring tumor subclonal populations | BMC Genomics | Full Text
Tracking the origins and drivers of subclonal metastatic expansion in prostate cancer. - Nuffield Department of Medicine
Analysis of the clonal architecture of the human small intestinal epithelium establishes a common stem cell for all lineages...
Mutational landscape and clonal architecture in grade II and III gliomas. - PubMed - NCBI
Monoclonal conversion in human gastric glands gives insights into stem cell and clonal architecture - Experimental Medicine...
The clonal evolution of metastatic colorectal cancer | Science Advances
Reliable detection of subclonal single-nucleotide variants in tumour cell populations - Zurich Open Repository and Archive
The predominant clonal evolution (PCE) concept of microbial pathogens and its practical usefulness | HSTalks
Cancer / Multi-organization Thematic Institutes / Header menu / aviesan
Cancer / Multi-organization Thematic Institutes / Header menu / aviesan
Chris Miller | McDonnell Genome Institute (MGI) | Washington University in St. Louis
Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade | Science
Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade | Science
The evolutionary history of 2,658 cancers | Nature
Mutagenesis by microbe: The role of the microbiota in shaping the cancer genome
Max Planck Research Groups | Max Planck Institute for Dynamics and Self-Organization
Plus it
The development of intratumoral heterogeneity in ovarian tumors: role of cancer stem cells in disease progression
Detection of Clonal and Subclonal Copy-Number Variants in Cell-Free DNA from Patients with Breast Cancer Using a Massively...
cancer - Is there a standard reference for the importance of tumor heterogeneity? - Biology Stack Exchange
Rabbit polyclonal to ADO - checkpoint 1 kinase inhibitor LY2603618 induces DNA damage and cell death
Plus it
Subclonal evolution of cancer-related gene mutations in p53 immunopositive patches in human skin - ePrints Soton
Download The Chachnamah An Ancient History Of Sind Sindh
Quantifying Clonal and Subclonal Passenger Mutations in Cancer Evolution
TP53 Clonal and Subclonal Architecture in Chronic Lymphocytic Leukemia Patients Under Ibrutinib Treatment | Blood | American...
Subclonal Genomic Architectures of Primary and Metastatic Colorectal Cancer Based on Intratumoral Genetic Heterogeneity |...
Abstract 3000: Defining the subclonal landscape of high-risk neuroblastoma | Childrens Brain Tumor Network
Relapsed childhood high hyperdiploid acute lymphoblastic leukemia : presence of preleukemic ancestral clones and the secondary...
Clonal Evolution, Genomic Drivers, and Effects of Therapy in Chronic Lymphocytic Leukemia | Clinical Cancer Research
Plus it
Plus it
David Jenkins | Computational Biomedicine
JNCCN 360
The Promise and the Hype of Personalised Medicine. - Department of Oncology
Most recent papers with the keyword Epigenetic resistance | Read by QxMD
Search of: 12437663 [PUBMED-IDS] - List Results - ClinicalTrials.gov
Landscape of somatic mutations and clonal evolution in mantle cell lymphoma | PNAS
Tracking clonal evolution and adapting therapy in metastatic colorectal cancer | OncologyPRO
Genetic heterogeneity in HER2 testing in breast cancer panel summary and guidelines<...
Publications by Trojnar, Eva - University of Regensburg Publication Server
Institut Curie Neuroblastoma data access Committee - EGA European Genome-Phenome Archive
Study Throws Light on Mutations Facilitating Cancer Cell Survival - Ask BioTecNika
Application of Liquid Biopsies in Cancer Targeted Therapy.
Tumor Heterogeneity and Personalized Medicine | Mendelspod
Deciphering intratumor heterogeneity and temporal acquisition of driver events to refine precision medicine | Genome Biology |...
Clonal Evolution in Aplastic Anemia is Driven by Chromosomal Instability Rather than Mutations in Myeloid Malignancy Candidate...
JCI -
Genomic and transcriptomic hallmarks of poorly differentiated and anaplastic thyroid cancers
Low Frequency ALK Hotspot… - Göteborgs universitet
Blackburn et al. Cancer Cell, 2014; (25):366-378 - Blackburn Lab
APLASTIC ANEMIA (AA) | MindMeister Mind Map
Universitätsklinikum Halle(Saale): 2012
The Immune System - Phagocytosis and Clonal Selection | i-Biology
10 janvier - Ville de Saint-Juéry
Carcinogenesis
Clonal evolution[edit]. Main article: Somatic evolution in cancer. Just like a population of animals undergoes evolution, an ... Clonal evolution[edit]. Main article: Somatic evolution in cancer. While genetic and epigenetic alterations in tumor suppressor ... the process of carcinogenesis is formally a process of Darwinian evolution, known as somatic or clonal evolution.[60] ... Nowell PC (October 1976). "The clonal evolution of tumor cell populations". Science. 194 (4260): 23-8. Bibcode:1976Sci...194... ...
Hugh Loxdale
Loxdale HD, Lushai G. (2003) Rapid changes in clonal lines: the death of a 'sacred cow'. Biological Journal of the Linnean ... Loxdale HD (2009) What's in a clone: the rapid evolution of aphid asexual lineages in relation to geography, host plant ... Loxdale has written reviews on absence of strict genetic uniformity in populations of clonal organisms such as aphids. This ... These include the migration and dispersal of insects in relation to their genotype and habitat; intra-clonal genetic variation ...
Aphid
Among the clonal population of these aphids, there may be several distinct morphs and this lays the foundation for a possible ... Chen, Rui; Wang, Zhe; Chen, Jing; Jiang, Li-Yun; Qiao, Ge-Xia (2017). "Insect-bacteria parallel evolution in multiple-co- ... However, there are differences between these sexual social insects and the clonal aphids, which are all descended from a single ... Eggs are parthenogenetically produced without meiosis and the offspring are clonal to their mother, so they are all female ( ...
Cancer stem cell
... better known as the somatic evolution model. The clonal evolution model, which occurs in both the CSC model and stochastic ... According to the "stochastic model" (or "clonal evolution model") every cancer cell in a tumor could gain the ability to self- ... 4). These two models are not mutually exclusive, as CSCs themselves undergo clonal evolution. Thus, the secondary more dominant ... Nowell PC (October 1976). "The clonal evolution of tumor cell populations". Science. 194 (4260): 23-8. Bibcode:1976Sci...194... ...
Tumour heterogeneity
The clonal evolution model was first proposed in 1976 by Peter Nowell. In this model, tumours arise from a single mutated cell ... These are the cancer stem cell model and the clonal evolution model. The models are not mutually exclusive, and it is believed ... Stem cell variability is often caused by epigenetic changes, but can also result from clonal evolution of the CSC population ... This has been suggested as a reliable method for tracking clonal evolution. However, this technique proves challenging in ...
Cancer
... termed clonal evolution, drives progression towards more invasive stages. Clonal evolution leads to intra-tumour heterogeneity ... Murgia C, Pritchard JK, Kim SY, Fassati A, Weiss RA (August 2006). "Clonal origin and evolution of a transmissible cancer". ... This rebellion-like scenario is an undesirable survival of the fittest, where the driving forces of evolution work against the ... Cancers usually arise from an assemblage of mutations and epimutations that confer a selective advantage leading to clonal ...
Clonally transmissible cancer
Murgia C, Pritchard JK, Kim SY, Fassati A, Weiss RA (August 2006). "Clonal origin and evolution of a transmissible cancer". ... Rebbeck CA, Thomas R, Breen M, Leroi AM, Burt A (September 2009). "Origins and evolution of a transmissible cancer". Evolution ... The evolution of transmissible cancer is unlikely, because the cell clone must be adapted to survive a physical transmission of ... The evolution of transmissible cancer has occurred naturally in other animal species, but-similarly to human cancer ...
Christopher E. Mason
"Dynamic evolution of clonal epialleles revealed by methclone". Genome Biology. 15 (9): 472. doi:10.1186/s13059-014-0472-5. ISSN ...
Canine transmissible venereal tumor
Murgia, C; Pritchard JK; Kim SY; Fassati A; Weiss RA (2006-08-11). "Clonal Origin and Evolution of a Transmissible Cancer". ... CS1 maint: discouraged parameter (link) Rebbeck CA, Thomas R, Breen M, Leroi AM, Burt A (2009). "Origins and Evolution of a ... Belov, Katherine; Jones, Elizabeth; Cheng, Yuanyuan (September 2015). "The origin, dynamics, and molecular evolution of ... Transmissible Cancer". Evolution. 63 (9): 2340-2349. doi:10.1111/j.1558-5646.2009.00724.x. PMID 19453727. Strakova, Andrea; ...
Genetic marker
Clonal origin and evolution of a transmissible cancer. Cell. 2006 Aug 11;126(3):477-87. Gomez-Raya L, Olsen HG, Lingaas F, ...
Pemphigus spyrothecae
Given this insignificant level of clonal mixing, there is a low chance for barriers to the evolution and propagation of an ... the researchers were able to examine the degree of clonal mixing in the colony. Clonal mixing is defined as the "mixing" of ... So, the researchers concluded that the aphids do not adapt to short-term changes in the colony via a reduction of clonal mixing ... However, further studies on colonies where the level of clonal mixing is predicted to be high would enable researchers to gain ...
Ambrosia fungi
2005): The Evolution of Agriculture in Insects. Annual Review of Ecology and Systematics, 36: 563-569. Malloch, D., and M. ... All ambrosia fungi are probably asexual and clonal. https://trec.ifas.ufl.edu/RAB-LW-2/pdfs/AB-LW-2016/Paul%20Rugman-Jones%20-% ...
Gynogenesis
Evolution; International Journal of Organic Evolution. 46 (6): 1935-1944. doi:10.1111/j.1558-5646.1992.tb01179.x. ISSN 1558- ... Avise, John C. (2015-07-21). "Evolutionary perspectives on clonal reproduction in vertebrate animals". Proceedings of the ... Schlupp, Ingo (2005). "The Evolutionary Ecology of Gynogenesis". Annual Review of Ecology, Evolution, and Systematics. 36: 399- ... Evolution. 34 (5): 917. doi:10.2307/2407997. hdl:2027.42/137459. ISSN 0014-3820. JSTOR 2407997.. ...
Cancer
... termed clonal evolution, drives progression towards more invasive stages.[76] Clonal evolution leads to intra-tumour ... "Clonal origin and evolution of a transmissible cancer". Cell. 126 (3): 477-87. doi:10.1016/j.cell.2006.05.051. PMC 2593932. ... This rebellion-like scenario is an undesirable survival of the fittest, where the driving forces of evolution work against the ... Cancers usually arise from an assemblage of mutations and epimutations that confer a selective advantage leading to clonal ...
Genetic marker
Clonal origin and evolution of a transmissible cancer. Cell. 2006 Aug 11;126(3):477-87. ...
Marbled crayfish
"Clonal genome evolution and rapid invasive spread of the marbled crayfish". Nature Ecology & Evolution. 2 (3): 567-573. doi: ... "Clonal genome evolution and rapid invasive spread of the marbled crayfish". Nature Ecology & Evolution. 2 (3): 567-573. doi: ... Günter Vogt (2010). "Suitability of the clonal marbled crayfish for biogerontological research: A review and perspective, with ... Development Genes and Evolution. 216 (4): 169-184. doi:10.1007/s00427-005-0041-8. PMID 16389558. ...
Cancer genome sequencing
January 2012). "Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing". Nature. 481 (7382): ... A big contribution to cancer death and failed cancer treatment is clonal evolution at the cytogenetic level, for example as ... 2010). "Evolution of an adenocarcinoma in response to selection by targeted kinase inhibitors". Genome Biology. 11 (8): R82. ... October 2009). "Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution". Nature. 461 (7265): ...
Ophiactis savignyi
McGovern, Tamara N. (2002). "Sex-ratio bias and clonal reproduction in the brittle star Ophiactis savignyi". Evolution. 56 (3 ...
Human cloning
"Journal of Evolution and Technology. 13.. [permanent dead link] *^ Cohen, Haley (31 July 2015). "How Champion-Pony Clones Have ... "Moving Toward a Clonal Man: Is This What We Want?" The Atlantic Monthly (1971). ... Lederberg Joshua (1966). "Experimental Genetics and Human Evolution". The American Naturalist. 100 (915): 519-531. doi:10.1086/ ...
Elaine Mardis
2012). "Clonal evolution in relapsed acute myeloid leukemia revealed by whole-genome sequencing". Nature. 481 (7382): 506-10. ...
Muller's ratchet
However, this fast evolution might also be due to these sequences' inability to repair DNA damage via template-assisted repair ... April 2018). "Clonal polymorphism and high heterozygosity in the celibate genome of the Amazon molly". Nature Ecology & ... Evolution of sexual reproduction Genetic hitchhiking Hill-Robertson effect Muller HJ (1932). "Some genetic aspects of sex". ... original paper as cited by, e.g.: Smith JM, Szathmary E (1997). The major transitions in evolution. Oxford, New York, Tokyo: ...
List of sequenced animal genomes
"Clonal genome evolution and rapid invasive spread of the marbled crayfish". Nature Ecology & Evolution. 2 (3): 567-573. doi: ... March 2015). "Convergent evolution of the genomes of marine mammals". Nature Genetics. 47 (3): 272-5. doi:10.1038/ng.3198. PMID ... November 2007). "Evolution of genes and genomes on the Drosophila phylogeny". Nature. 450 (7167): 203-18. Bibcode:2007Natur.450 ... Genomic basis for the convergent evolution of electric organs". Science. 344 (6191): 1522-5. doi:10.1126/science.1254432. PMID ...
Marbled crayfish
"Clonal genome evolution and rapid invasive spread of the marbled crayfish". Nature Ecology & Evolution. doi:10.1038/s41559-018- ... Günter Vogt (2010). "Suitability of the clonal marbled crayfish for biogerontological research: A review and perspective, with ... Development Genes and Evolution. 216 (4): 169-184. doi:10.1007/s00427-005-0041-8.. ...
Mouse models of breast cancer metastasis
"Genetic heterogeneity and clonal evolution underlying development of asynchronous metastasis in human breast cancer". Cancer ... This explains the concept of tumour heterogeneity and the order of genetic events during tumor evolution. Many of the genes ... The genetic profiles of primary and metastatic lesions in breast carcinomas show a large extent of clonal pertinence between ... "Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution". Nature. 461 (7265): 809-13. doi: ...
Fucus radicans
"Complex spatial clonal structure in the macroalgae Fucus radicans with both sexual and asexual recruitment". Ecology and ... Evolution. 5 (19): 4233-4245. doi:10.1002/ece3.1629. ISSN 2045-7758. PMC 4667831. PMID 26664675. "BAMBI, Baltic Sea Marine ...
PyClone
According to the Clonal Evolution model proposed by Peter Nowell, a mutated cancer cell can accumulate more mutations as it ... "Multifocal clonal evolution characterized using circulating tumour DNA in a case of metastatic breast cancer". Nature ... Inferring Clonal Architecture and Tracking the Spatial and Temporal Patterns of Tumor Evolution". PLOS Computational Biology. ... Understanding clonal dynamics improves understanding on how related cancers such as MDS, MPN and sAML compare in risk and give ...
Bacterial recombination
Evolution in bacteria was previously viewed as a result of mutation or genetic drift. Today, genetic exchange, or gene transfer ... This clonal nature leads to random mutations that occur during DNA replication that potentially helps bacteria evolve. It was ... The importance of evolution in bacterial recombination is its adaptivity. For example, bacterial recombination has been shown ... Shapiro, B. Jesse (2016-03-24). "How clonal are bacteria over time?". bioRxiv: 036780. doi:10.1101/036780. Levin, Bruce R.; ...
List of phylogenetics software
Paradis E, Claude J, Strimmer K (January 2004). "APE: Analyses of Phylogenetics and Evolution in R language". Bioinformatics. ... "Reconstruction of clonal trees and tumor composition from multi-sample sequencing data". Bioinformatics. 31 (12): i62-70. doi: ... Molecular Biology and Evolution. 23 (2): 254-67. doi:10.1093/molbev/msj030. PMID 16221896. Jobb G, von Haeseler A, Strimmer K ( ... Molecular Biology and Evolution. 29 (8): 1969-1973. doi:10.1093/molbev/mss075. PMC 3408070. PMID 22367748. Jiang Y, Qiu Y, Minn ...
Muller plot
Maddamsetti, Rohan; Lenski, Richard E.; Barrick, Jeffrey E. (2015). "Adaptation, Clonal Interference, and Frequency Dependent ... Interactions in a Long Term Evolution Experiment with Escherichia coli". Genetics. 200 (2): 619-631. doi:10.1534/genetics. ...
Immunosenescence
... decreases impaired proliferation in response to antigenic stimulation the accumulation and the clonal expansion of memory and ... and harmful agents early in life and in adulthood become detrimental late in life in a period largely not foreseen by evolution ...
Pecan
"USDA Pecan Breeding Program, National Clonal Germplasm Repository for Pecans and Hickories". Horticulture Dept. Retrieved 6 Dec ... "Evolution, Phylogeny, and Systematics of Juglandaceae" (PDF). Annals of the Missouri Botanical Garden. Missouri Botanical ...
List of atheists in science and technology
... especially evolution; one of the best known contemporary popular writers on evolution.[175][176] ... He won the Nobel Prize in 1960 for predicting acquired immune tolerance and was best known for developing the theory of clonal ... "Man's evolution as a neotenous ape has put him in a similar position to the dog's. He becomes sexually mature and yet he still ... R. L. Wysong (1976). "5: Origin of Proteins". The Creation-evolution Controversy (implications, Methodology and Survey of ...
Symbiodinium, a enciclopedia libre
Os poucos estudos que se fixeron sobre a dispersión clonal atoparon que a maioría dos xenotipos teñen distribucións xeográficas ... and evolution through psbA non-coding region genotyping. PlosOne e29013 ... Utilizando marcadores microsatélite para identificar xenotipos multilocus, pode resolverse unha soa liña clonal de Symbiodinium ... clonal) de Symbiodinium. Nalgunhas colonias poden aparecer xenotipos adicionais, mais é raro atopar máis de dous ou tres. Cando ...
Glossary of biology
clonal selection. A scientific theory in immunology that explains the functions of cells (lymphocytes) of the immune system in ... evolution. The change in the heritable characteristics of populations of biological organisms over successive generations, ... parallel evolution. The development of a similar trait in related, but distinct, species descending from the same ancestor, but ... Evolution on a scale of separated gene pools. Macroevolutionary studies focus on change that occurs at or above the level of ...
Antigen
Janeway CA, Jr (1 November 2013). "Pillars article: approaching the asymptote? Evolution and revolution in immunology. Cold ...
Development of analogs of thalidomide
Bartlett, J. Blake; Dredge, Keith; Dalgleish, Angus G. (1 April 2004). "Timeline: The evolution of thalidomide and its IMiD ... Lenalidomide and pomalidomide are about 100-1000 times more potent in stimulating T-cell clonal proliferation than thalidomide ... data suggests this co-stimulation leads to increased Th1 type cytokine release of IFN-γ and IL-2 that further stimulates clonal ...
Single cell sequencing
... and disease evolution can all be elucidated through single cell sequencing.[5] Single cell sequencing was selected as the ... a population of the same species can appear to be genetically clonal, but single-cell sequencing of RNA or epigenetic ... "Distant metastasis occurs late during the genetic evolution of pancreatic cancer". Nature. 467 (7319): 1114-7. Bibcode ... "High-throughput targeted long-read single cell sequencing reveals the clonal and transcriptional landscape of lymphocytes" ...
Anastomosis
Evolution[edit]. In evolution, anastomosis is a recombination of evolutionary lineage. Conventional accounts of evolutionary ... fusing to form a genetic singular clonal colony that can cover hectares called a genet or just microscopical areas.[9] ...
Autoimmunity
Clonal Anergy theory, proposed by Nossal, in which self-reactive T- or B-cells become inactivated in the normal individual and ... Dunne DW, Cooke A (2005). "A worm's eye view of the immune system: consequences for evolution of human autoimmune disease". ... Clonal Deletion theory, proposed by Burnet, according to which self-reactive lymphoid cells are destroyed during the ... Clonal Ignorance theory, according to which autoreactive T cells that are not represented in the thymus will mature and migrate ...
NMDA receptor
"The origin and evolution of synapses". Nature Reviews. Neuroscience. 10 (11): 701-712. doi:10.1038/Nrn2748. PMID 19738623 ... "Timing neurogenesis and differentiation: insights from quantitative clonal analyses of cerebellar granule cells". The Journal ...
Primary myelofibrosis
Myelofibrosis is a clonal neoplastic disorder of hematopoiesis, the formation of blood cellular components. It is one of the ... In these cases, myelofibrosis occurs as a result of somatic evolution of the abnormal hematopoietic stem cell clone that caused ... Further thoughts on the nosology of the clonal myeloid disorders". Leukemia. 19 (7): 1139-41. doi:10.1038/sj.leu.2403804. PMID ...
Protist
Unity, diversity and evolution. Ed.: Barry S. C. Leadbeater and J. C. Green Taylor and Francis, London 2000, p. 3. ... "Are eukaryotic microorganisms clonal or sexual? A population genetics vantage". Proceedings of the National Academy of ... Dacks J, Roger AJ (June 1999). "The first sexual lineage and the relevance of facultative sex". Journal of Molecular Evolution ... Eukaryotes emerged in evolution more than 1.5 billion years ago.[47] The earliest eukaryotes were likely protists. Although ...
DNA sequencing
Another method for in vitro clonal amplification is bridge PCR, in which fragments are amplified upon primers attached to a ... "Introducing 'dark DNA' - the phenomenon that could change how we think about evolution".. ... A polymerase chain reaction (PCR) then coats each bead with clonal copies of the DNA molecule followed by immobilization for ... which involves the clonal amplification of DNA on a surface. The cluster technology was co-acquired with Lynx Therapeutics of ...
Opuntia
... spreads into large clonal colonies, which contribute to its being considered a noxious weed in some places.[1][3] ... "Phylogeny of Opuntia s.s. (Cactaceae): Clade delineation, geographic origins, and reticulate evolution". American Journal of ...
Kentucky coffeetree
Barlow, Connie (2000). The Ghosts of Evolution: Nonsensical Fruit, Missing Partners, and Other Ecological Anachronisms. New ... Here it can form large clonal colonies, reproducing by shoots sprouting from roots. ...
Genetics
Gillespie JH (November 2001). "Is the population size of a species relevant to its evolution?". Evolution; International ... "clonal") organisms). ... Natural selection and evolutionEdit. Main article: Evolution. ... In evolution, this chromosome has lost most of its content and also most of its genes, while the X chromosome is similar to the ... Staub JE (1994). Crossover: Concepts and Applications in Genetics, Evolution, and Breeding. University of Wisconsin Press. p. ...
Nature versus nurture
Craven, Hamilton (1978) The Triumph of Evolution: The Heredity-Environment Controversy, 1900-1941: "While it would be ... The heritability index for all traits would be zero (all variability between clonal individuals must be due to environmental ... Darwin's Theory of Evolution steered naturalists such as George Williams and William Hamilton to the concept of personality ... Symons, D. (1979). The evolution of human sexuality. Oxford: Oxford University Press.. ...
Adaptive immune system
Myriad receptors are produced through a process known as clonal selection.[1][2] According to the clonal selection theory, at ... EvolutionEdit. The acquired immune system, which has been best-studied in mammals, originated in jawed fish approximately 500 ... The evolution of the AIS, based on Ig, TCR, and MHC molecules, is thought to have arisen from two major evolutionary events: ... Rogozin IB, Iyer LM, Liang L, Glazko GV, Liston VG, Pavlov YI, Aravind L, Pancer Z (June 2007). "Evolution and diversification ...
Antibody
Stavnezer J, Amemiya CT (2004). "Evolution of isotype switching". Semin. Immunol. 16 (4): 257-275. doi:10.1016/j.smim.2004.08. ... Circulating antibodies are produced by clonal B cells that specifically respond to only one antigen (an example is a virus ... This recombinational process that produces clonal antibody paratope diversity is called V(D)J or VJ recombination. Basically, ... "V(D)J recombination and the evolution of the adaptive immune system". PLoS Biol. 1 (1): E16. doi:10.1371/journal.pbio.0000016 ...
Fission (biology)
Clonal fragmentation[edit]. Main article: Fragmentation (reproduction). Fragmentation in multicellular or colonial organisms is ... Samson, RY; Bell, SD (November 2009). "Ancient ESCRTs and the evolution of binary fission". Trends in Microbiology. 17 (11): ... "Evolution of diverse cell division and vesicle formation systems in Archaea". Nature Reviews. Microbiology. 8 (10): 731-41. ...
Potato
David R. Harris, Gordon C. Hillman, Foraging and Farming: The Evolution of Plant Exploitation. Routledge, 2014 ISBN 1-317-59829 ... The consistent parenchyma tissue, the clonal nature of the plant and the low metabolic activity provide a very nice "model ... Hawkes, J.G. (1990). The Potato: Evolution, Biodiversity & Genetic Resources, Smithsonian Institution Press, Washington, DC ...
X-inactivation
Stanley Michael Gartler used X chromosome inactivation to demonstrate the clonal origin of cancers. Examining normal tissues ... "Sex-differential selection and the evolution of X inactivation strategies". PLoS Genetics. 9 (4): e1003440. doi:10.1371/ ... "Evaluation of clonal origin of malignant mesothelioma". Journal of Translational Medicine. 12: 301. doi:10.1186/s12967-014- ...
Organ (anatomy)
Origin and evolution[edit]. Relationship of major animal lineages with indication of how long ago these animals shared a common ... see clonal colony). ... Studies on the evolution of the placenta have identified a ... Griffith, Oliver W.; Wagner, G?nter P. (23 March 2017). "The placenta as a model for understanding the origin and evolution of ... vertebrate organs". Nature Ecology & Evolution. 1 (4): 0072. doi:10.1038/s41559-017-0072.. ...
Yeast
Katz Ezov et al.[43] presented evidence that in natural S. cerevisiae populations clonal reproduction and selfing (in the form ... McBryde C, Gardner JM, de Barros Lopes M, Jiranek V (2006). "Generation of novel wine yeast strains by adaptive evolution". ... In nature, mating of haploid cells to form diploid cells is most often between members of the same clonal population and out- ...
Ficus
Evolution; international journal of organic evolution. 57 (6): 1255-1269. doi:10.1554/02-445.. ... The Great Banyan - a F. benghalensis, a clonal colony and once the largest organism known ... Evolution. Society for the Study of Evolution. 33 (2): 673-685. doi:10.2307/2407790. JSTOR 2407790.. ... recent genetic and molecular dating analyses have shown a very close correspondence in the character evolution and speciation ...
Քաղցկեղ - Վիքիպեդիա՝ ազատ հանրագիտարան
Clonal origin and evolution of a transmissible cancer»։ Cell 126 (3): 477-87։ August 2006։ PMC 2593932։ PMID 16901782։ doi: ...
Human hair growth
"Redefining the structure of the hair follicle by 3D clonal analysis". Development. 139 (20): 3741-3751. doi:10.1242/dev.081091 ... Evolution of hair. ReferencesEdit. *^ Natural Hair Growth. Cardiff, United Kingdom: Health4sure. 2018.. .mw-parser-output cite. ...
Fertilisation
EvolutionEdit. The evolution of fertilisation is related to the origin of meiosis, as both are part of sexual reproduction, ... "Simultaneous Mendelian and clonal genome transmission in a sexually reproducing, all-triploid vertebrate". Proceedings of the ... "The evolution of selfing in Arabidopsis thaliana". Science. 317 (5841): 1070-2. doi:10.1126/science.1143153. PMID 17656687.. ... Evolution. 57 (2): 216-30. doi:10.1111/j.0014-3820.2003.tb00257.x. PMID 12683519.. ...
Clonal evolution in cancer. - PubMed - NCBI
a) Branching clonal architecture of clonal evolution in cancer. Selective pressures allow some mutant sub-clones to expand ... Divergent (branching) clonal evolution of cancer with topographical separation.. In each example, a clonal (single cell) ... Clonal evolution in cancer.. Greaves M1, Maley CC.. Author information. 1. Division of Molecular Pathology, The Institute of ... Cancers evolve by a reiterative process of clonal expansion, genetic diversification and clonal selection within the adaptive ...
Article Metrics - Clonal evolution in myelodysplastic syndromes | Nature Communications
Altmetric calculates a score based on the online attention an article receives. Each coloured thread in the circle represents a different type of online attention. The number in the centre is the Altmetric score. Social media and mainstream news media are the main sources that calculate the score. Reference managers such as Mendeley are also tracked but do not contribute to the score. Older articles often score higher because they have had more time to get noticed. To account for this, Altmetric has included the context data for other articles of a similar age. ...
Breast tumor heterogeneity: cancer stem cells or clonal evolution? - PubMed - NCBI
Two popular concepts that attempt to explain this are the cancer stem cell hypothesis and the clonal evolution model. Each of ... Breast tumor heterogeneity: cancer stem cells or clonal evolution?. Campbell LL1, Polyak K. ... suggests how the cancer stem cell hypothesis and the clonal evolution model may be involved in generating breast tumor ...
Landscape of somatic mutations and clonal evolution in mantle cell lymphoma | PNAS
Landscape of somatic mutations and clonal evolution in mantle cell lymphoma Message Subject (Your Name) has sent you a message ... Landscape of somatic mutations and clonal evolution in mantle cell lymphoma. Sílvia Beà, Rafael Valdés-Mas, Alba Navarro, ... Some mutations were predominantly clonal or subclonal, indicating an early or late event in tumor evolution, respectively. Our ...
Sequencing Offers Clues to Clonal Evolution in Aplastic Anemia | GenomeWeb
Researchers sequenced samples from hundreds of individuals with aplastic anemia to narrow in on somatic mutation and clonal ... Home » Tools & Technology » Sequencing » Sequencing Offers Clues to Clonal Evolution in Aplastic Anemia ... Sequencing Offers Clues to Clonal Evolution in Aplastic Anemia. Jul 02, 2015 ... researchers from the US and Japan described mutation and clonal dynamic patterns in aplastic anemia - a non-cancerous condition ...
Molecular evolution of the Escherichia coli chromosome. III. Clonal frames. | Genetics
Molecular evolution of the Escherichia coli chromosome. III. Clonal frames. Message Subject (Your Name) has forwarded a page to ... Molecular evolution of the Escherichia coli chromosome. III. Clonal frames.. R Milkman and M M Bridges ... Molecular evolution of the Escherichia coli chromosome. III. Clonal frames.. R Milkman and M M Bridges ... Molecular evolution of the Escherichia coli chromosome. III. Clonal frames.. R Milkman and M M Bridges ...
Clonal Interference and the Evolution of RNA Viruses | Science
This evidence, along with models of clonal interference (1-4), allows certain properties of the adaptive evolution of RNA ... suggests that clonal interference may play an important role in their adaptive evolution. Our goal here is to infer the ... The clonal interference model used to estimate μb andE(s) makes two important assumptions. The first is that selection ... The model of clonal interference (4) has the additional advantage of allowing us to estimate the beneficial mutation rate (μb) ...
The clonal evolution of tumor cell populations | Science
It is proposed that most neoplasms arise from a single cell of origin, and tumor progression results from acquired genetic variability within the original clone allowing sequential selection of more aggressive sublines. Tumor cell populations are apparently more genetically unstable than normal cells, perhaps from activation of specific gene loci in the neoplasm, continued presence of carcinogen, or even nutritional deficiencies within the tumor. The acquired genetic insta0ility and associated selection process, most readily recognized cytogenetically, results in advanced human malignancies being highly individual karyotypically and biologically. Hence, each patients cancer may require individual specific therapy, and even this may be thwarted by emergence of a genetically variant subline resistant to the treatment. More research should be directed toward understanding and controlling the evolutionary process in tumors before it reaches the late stage usually seen in clinical cancer.. ...
Clonal evolution in hematological malignancies and therapeutic implications
... Leukemia. 2014 Jan;28(1):34-43. doi: 10.1038/leu. ... New insights into this process challenge us to understand the impact of treatment on clonal evolution and inspire the ... They also suggest that while clonal evolution may contribute to resistance to therapy, treatment may also hasten the ...
Clonal evolution and clinical correlates of somatic mutations in myeloproliferative neoplasms
... are a group of clonal disorders characterized by aberrant hematopoietic proliferation and an increased tendency toward leukemic ... Clonal evolution and clinical correlates of somatic mutations in myeloproliferative neoplasms Blood. 2014 Apr 3;123(14):2220-8. ... of 104 genes to detect somatic mutations in a cohort of 197 MPN patients and followed clonal evolution and the impact on ... Myeloproliferative neoplasms (MPNs) are a group of clonal disorders characterized by aberrant hematopoietic proliferation and ...
The clonal evolution of metastatic colorectal cancer | Science Advances
Fishplot of clonal evolution and (D) clonal admixture of individual samples. (E) Clonal evolution tree with branch length ... 2 Clonal evolution in mCRC: From primary to metastasis and patient-derived xenograft.. Each patients clonal history is ... We observed intricate clonal heterogeneity and evolution affecting metastasis dissemination and PDX clonal selection. ... Our clonal evolution models revealed four cases (CRC3, CRC8, CRC9, and CRC10) where the clonal marker variants of the ...
Exome, Targeted Sequencing of Biopsy, ctDNA Reveals Clonal Evolution of Breast Cancer Tumors | GenomeWeb
Exome, Targeted Sequencing of Biopsy, ctDNA Reveals Clonal Evolution of Breast Cancer Tumors. Nov 16, 2015 ... Home » Exome, Targeted Sequencing of Biopsy, ctDNA Reveals Clonal Evolution of Breast Cancer Tumors ... tumor DNA to characterize the genomic architecture of a breast cancer patients tumor and track its clonal evolution over time ...
Sequential evolution of virulence and resistance during clonal spread of community-acquired methicillin-resistant...
Sequential evolution of virulence and resistance during clonal spread of community-acquired methicillin-resistant ... Sequential evolution of virulence and resistance during clonal spread of community-acquired methicillin-resistant ... Sequential evolution of virulence and resistance during clonal spread of community-acquired methicillin-resistant ... Sequential evolution of virulence and resistance during clonal spread of community-acquired methicillin-resistant ...
Cancers | Free Full-Text | Lung Cancers: Molecular Characterization, Clonal Heterogeneity and Evolution, and Cancer Stem Cells
Molecular studies performed on lung tumors during treatment have shown the phenomenon of clonal evolution, thus supporting the ... Lung Cancers: Molecular Characterization, Clonal Heterogeneity and Evolution, and Cancer Stem Cells. Ugo Testa * , Germana ... Molecular studies performed on lung tumors during treatment have shown the phenomenon of clonal evolution, thus supporting the ... Testa U, Castelli G, Pelosi E. Lung Cancers: Molecular Characterization, Clonal Heterogeneity and Evolution, and Cancer Stem ...
talks.cam : Origins and clonal evolution of childhood leukaemia
Origins and clonal evolution of childhood leukaemia. Add to your list(s) Download to your calendar using vCal ... University of Cambridge , Talks.cam , Cancer Research UK Cambridge Institute (CRUK CI) Seminars in Cancer , Origins and clonal ... Overall, our studies suggest that clonal selection in leukaemia results from the combined influence of genetic and epigenetic ...
Quantifying Clonal and Subclonal Passenger Mutations in Cancer Evolution
The impact of clonal evolution on response to imatinib mesylate (STI571) in accelerated phase CML | Blood Journal
Fifteen patients had clonal evolution alone (AP-CE), 32 had AP features but no evidence of clonal evolution (HEM-AP), and 24 ... and a third group had accelerated phase features plus clonal evolution (HEM-AP + CE, n = 24) (Table4). Clonal evolution ... The impact of clonal evolution on response to imatinib mesylate (STI571) in accelerated phase CML. Michael E. ODwyer, Michael ... The impact of clonal evolution on response to imatinib mesylate (STI571) in accelerated phase CML. Blood, 100(5), 1628-1633. ...
Chromothripsis-Mediated Structural Variations and Clonal Evolution In Recurrent Childhood High Hyperdiploid Acute Lymphoblastic...
Chromothripsis-Mediated Structural Variations and Clonal Evolution In Recurrent Childhood High Hyperdiploid Acute Lymphoblastic ... Chromothripsis-Mediated Structural Variations and Clonal Evolution In Recurrent Childhood High Hyperdiploid Acute Lymphoblastic ... Chromothripsis-Mediated Structural Variations and Clonal Evolution In Recurrent Childhood High Hyperdiploid Acute Lymphoblastic ... Chromothripsis-Mediated Structural Variations and Clonal Evolution In Recurrent Childhood High Hyperdiploid Acute Lymphoblastic ...
Figure 3 - Evolution of Sequence Type 4821 Clonal Complex Hyperinvasive and Quinolone-Resistant Meningococci - Volume 27,...
Expansion of quinolone-resistant Neisseria meningitidis clone ChinaCC4821-R1-C/B from sequence type (ST) 4821 clonal complex ( ... Evolution of Sequence Type 4821 Clonal Complex Hyperinvasive and Quinolone-Resistant Meningococci Mingliang Chen1. , Odile B. ... Evolution of Sequence Type 4821 Clonal Complex Hyperinvasive and Quinolone-Resistant Meningococci. ... Phylogenetic tree and data of clonal complex 4821 Neisseria meningitidis sublineage L44.1 (ChinaCC4821-R1-C/B) isolates. Red ...
Evolution of Sequence Type 4821 Clonal Complex Hyperinvasive and Quinolone-Resistant Meningococci - Volume 27, Number 4-April...
Guo Q, Mustapha MM, Chen M, Qu D, Zhang X, Chen M, et al. Evolution of sequence type 4821 clonal complex meningococcal strains ... Evolution of Sequence Type 4821 Clonal Complex Hyperinvasive and Quinolone-Resistant Meningococci On This Page ... Evolution of Sequence Type 4821 Clonal Complex Hyperinvasive and Quinolone-Resistant Meningococci. Emerging Infectious Diseases ... Evolution of Sequence Type 4821 Clonal Complex Hyperinvasive and Quinolone-Resistant Meningococci. Volume 27, Number 4-April ...
Clonal Evolution through Loss of Chromosomes and Subsequent Polyploidization in Chondrosarcoma.
Acute myeloid leukaemia: a paradigm for the clonal evolution of cancer? | Disease Models & Mechanisms
Clonal Evolution, Genomic Drivers, and Effects of Therapy in Chronic Lymphocytic Leukemia | Clinical Cancer Research
... and TP53 mutations during clonal evolution in CLL. We proceeded with a detailed review of all dominant clonal changes in paired ... Clonal Evolution, Genomic Drivers, and Effects of Therapy in Chronic Lymphocytic Leukemia. Peter Ouillette, Kamlai Saiya-Cork, ... Overall, clonal evolution and acquisition involving aCNAs was detected in 21 of these cases, novel cn-LOH developed in 6 cases ... Clonal evolution in chronic lymphocytic leukemia: acquisition of high-risk genomic aberrations associated with unmutated VH, ...
Evolution of the Antigen-Specific CD8+ TCR Repertoire across the Life Span: Evidence for Clonal Homogenization of the Old TCR...
Evolution of the Antigen-Specific CD8+ TCR Repertoire across the Life Span: Evidence for Clonal Homogenization of the Old TCR ... Evolution of the Antigen-Specific CD8+ TCR Repertoire across the Life Span: Evidence for Clonal Homogenization of the Old TCR ... Evolution of the Antigen-Specific CD8+ TCR Repertoire across the Life Span: Evidence for Clonal Homogenization of the Old TCR ... Evolution of the Antigen-Specific CD8+ TCR Repertoire across the Life Span: Evidence for Clonal Homogenization of the Old TCR ...
Detailed analysis of therapy-driven clonal evolution of TP53 mutations in chronic lymphocytic leukemia | Masaryk University
Detailed analysis of therapy-driven clonal evolution of TP53 mutations in chronic lymphocytic leukemia. Authors. MALČÍKOVÁ ... Using ultra-deep next-generation sequencing (NGS), we performed a detailed analysis of TP53 mutations clonal evolution. We ... Detailed analysis of therapy-driven clonal evolution of TP53 mutations in chronic lymphocytic leukemia ...
Study Identifies Factors in Clonal Evolution of Chemotherapy-Resistant Urothelial Carcinoma - The ASCO Post
Study Identifies Factors in Clonal Evolution of Chemotherapy-Resistant Urothelial Carcinoma. By Matthew Stenger. December 25, ... 1. Faltas BM, Prandi D, Tagawa ST, et al: Clonal evolution of chemotherapy-resistant urothelial carcinoma. Nat Genet 48:1490- ... Understanding how selective pressure from chemotherapy directs the evolution of urothelial carcinoma and shapes its clonal ... Clonal Mutations. Chemotherapy-treated urothelial carcinoma is enriched with clonal mutations involving L1 cell adhesion ...
The predominant clonal evolution (PCE) concept of microbial pathogens and its practical usefulness | HSTalks
Michel Tibayrenc on The predominant clonal evolution (PCE) concept of microbial pathogens and its practical usefulness, part of ... The predominant clonal evolution (PCE) concept of microbial pathogens and its practical usefulness. *Dr. Michel Tibayrenc - ... The predominant clonal evolution of parch is of interest to all kinds of pathogenic microorganisms. Eukaryotic, parasitic ... The predominant clonal evolution (PCE) concept of microbial pathogens and its practical usefulness. Embed in course/own notes ...
Evolution of Clonal and Susceptibility Profiles of Serotype 19A Streptococcus pneumoniae among Invasive Isolates from Children...
Evolution of Clonal and Susceptibility Profiles of Serotype 19A Streptococcus pneumoniae among Invasive Isolates from Children ... Evolution of Clonal and Susceptibility Profiles of Serotype 19A Streptococcus pneumoniae among Invasive Isolates from Children ... Evolution of Clonal and Susceptibility Profiles of Serotype 19A Streptococcus pneumoniae among Invasive Isolates from Children ... Evolution of Clonal and Susceptibility Profiles of Serotype 19A Streptococcus pneumoniae among Invasive Isolates from Children ...
Acquired Resistance and Clonal Evolution in Melanoma during BRAF Inhibitor Therapy | Cancer Discovery
Acquired Resistance and Clonal Evolution in Melanoma during BRAF Inhibitor Therapy. Hubing Shi, Willy Hugo, Xiangju Kong, ... Acquired Resistance and Clonal Evolution in Melanoma during BRAF Inhibitor Therapy. Hubing Shi, Willy Hugo, Xiangju Kong, ... Acquired Resistance and Clonal Evolution in Melanoma during BRAF Inhibitor Therapy. Hubing Shi, Willy Hugo, Xiangju Kong, ... Acquired Resistance and Clonal Evolution in Melanoma during BRAF Inhibitor Therapy Message Subject (Your Name) has forwarded a ...
Unusual clonal evolution involving 5q in a case of myelodysplastic syndrome with deletion 5q 31 treated with lenalidomide |...
To our knowledge, this is the first report of clonal evolution involving chromosome 5 occurring during the evolution of MDS ... Unusual clonal evolution involving 5q in a case of myelodysplastic syndrome with deletion 5q 31 treated with lenalidomide ... Unusual clonal evolution involving 5q in a case of myelodysplastic syndrome with deletion 5q 31 treated with lenalidomide ... Unusual clonal evolution involving 5q in a case of myelodysplastic syndrome with deletion 5q 31 treated with lenalidomide ...
PopulationsGeneticHeterogeneity and clonal evolutionMutationClonesChronic LymphocyLineagesHematopoiesis of indeterminate potentialCancersCourse of clonal evolutionStudies of clonal evolutionPatients with clonal evolutionHematopoieticChromosomeProgressionLead to clonalSkipPresence of clonalAplastic anemiaTumorsBeneficial mutationsGenomeComplexesCell clonalHighly clonalPhenomenonAcuteGenomicHypothesisPeter NowellTherapeuticLeukemiaSomatic cellsSelectiveCancer stemDiversityTumourChromosomalProliferationDiversificationStem cellImplications2018Cytogenetic evolutionNeoplasmsPhenotypeDominanceInterferenceClinicalPathwaysMetastatic spreadProgenitor cellEvidenceDivergentIsolates4821CytogeneticsHierarchy
Populations19
- Clonal interference also increases the time between fixations, thereby slowing the adaptation of asexual populations. (sciencemag.org)
- Our goal here is to infer the presence of clonal interference acting on viral populations. (sciencemag.org)
- Wolinska, Justyna 2018-01-01 00:00:00 According to the Red Queen hypothesis, clonal diversity in asexual populations could be maintained by negative frequency‐dependant selection by coevolving parasites. (deepdyve.com)
- Significant differences in the clonal composition between random and infected subsamples of Daphnia populations were detected on six of seven tested occasions, confirming genetic specificity of the host-parasite interaction in this system. (deepdyve.com)
- Assortment arises in structured populations and means that individuals interact with genetically similar individuals at a higher than average probability-promoting the evolution of social traits. (royalsocietypublishing.org)
- Overall, our study provides a simple approach for removing PCR duplicates using an accessible deep-targeted sequencing kit and suggests that duplicates must be accounted for to obtain accurate frequency estimates important for studying heterogeneous populations, such as in studies of clonal evolution and cancer heterogeneity. (biomedcentral.com)
- The conventional model of adaptation in asexual populations implies sequential fixation of new beneficial mutations via rare selective sweeps that purge all variation and preserve the clonal genotype. (genetics.org)
- However, in large populations multiple beneficial mutations may co-occur, causing competition among them, a phenomenon called "clonal interference. (genetics.org)
- Here, we study the significance of clonal interference in populations consisting of mixtures of differently marked wild-type and mutator strains of Escherichia coli that adapt to a minimal-glucose environment for 400 generations. (genetics.org)
- The results demonstrate the presence of multiple beneficial mutations in these populations and slower and more erratic invasion of mutants than expected by the conventional model, showing the signature of clonal interference. (genetics.org)
- Here we aim to find more direct evidence of clonal interference by studying the invasion of new beneficial mutations in evolving populations of Escherichia coli . (genetics.org)
- The fundamental hypothesis of our studies is that cancers consist of heterogeneous populations that can rapidly respond to stress (e.g. cytotoxic therapies) by exploiting fundamental principles of evolution. (asu.edu)
- These behaviors are of major clinical significance for both primary and metastatic cancers where distinct clonal populations of tumor cells with variable evolutionary fitness are dispersed to multiple sites within a patient. (asu.edu)
- In a similar vein, other studies using the HUMARA technology had found that hematologic malignancies are clonal diseases even when there is no apparent chromosomal abnormality, and that there are pre-leukemic clonal populations which precede acute myeloid leukemia (AML). (wikipedia.org)
- The combination of these two ideas, that clonal hematopoiesis might be common in the elderly population and that AML evolves from pre-leukemic populations, led to the hypothesis that malignancy-associated mutations could also contribute to asymptomatic clonal hematopoiesis in healthy individuals. (wikipedia.org)
- Additionally, developing a method to place gene fusions in the context of (founder or sub-) clonal tumor cell populations will improve our understanding of their role in tumor progression and treatment response. (grantome.com)
- The heterogeneity found in cells of carcinogenic tumours implies competition between sub-populations of cells in the tumour, hence clonal interference. (wikipedia.org)
- Here, genomics analyses of isolates from this rapidly expanding clonal population offered an opportunity to observe the molecular evolutionary changes often obscured in more diverse populations. (biomedcentral.com)
- Nearly 40% of AA patients carry somatic mutations in the PIGA gene manifested as clonal populations of cells with the paroxysmal nocturnal hemoglobinuria phenotype, and 17% of AA patients have loss of HLA class I alleles. (ashpublications.org)
Genetic23
- Cancers evolve by a reiterative process of clonal expansion, genetic diversification and clonal selection within the adaptive landscapes of tissue ecosystems. (nih.gov)
- The dynamics are complex, with highly variable patterns of genetic diversity and resulting clonal architecture. (nih.gov)
- Overall, our studies suggest that clonal selection in leukaemia results from the combined influence of genetic and epigenetic variations. (cam.ac.uk)
- genetic relationships among isolates are defined by clonal complexes (CCs) identified by multilocus sequence typing (MLST), which are surrogates for lineages ( 2 ). (cdc.gov)
- Progression of malignant tumors is largely due to clonal evolution of the primary tumor, clones acquiring different sets of molecular genetic lesions. (urotoday.com)
- This literature is littered with imprecise subjective assertions such as strong influence of recombination, far from being a clonal species, extensive genetic exchange which are both informative. (hstalks.com)
- In this model, metastasis represents the end stage of evolution, and the presence of genetic alterations responsible for the metastatic ability of tumor cells is predicted. (aacrjournals.org)
- One of the principal goals of large-scale genome sequencing of somatic tissues is to uncover genetic loci under positive selection, so-called 'driver' genes, that lead to clonal expansions. (elifesciences.org)
- Conversely, recent studies have revealed that clonal evolution of premalignant B-cell precursors toward leukemia as a result of in vivo infection exposure takes place through acquisition of secondary genetic events no related to mutated hotspots for AID activity in both patient-derived B-ALL and mouse models mimicking the human genetic predisposition to B-ALL. (cicancer.org)
- Based on these observations we examined here, in two genetic approaches, whether AID is required for clonal evolution of pre-malignant B-cells in the etiology of infection-associated B-ALL. (cicancer.org)
- Surprisingly, however, latency, penetrance and genetic characteristics of B-ALL was not affected by genetic deletion of Aid in Pax5-haploinsufficient mice, suggesting that AID was dispensable for clonal evolution in this model. (cicancer.org)
- During the evolution of MM, tumour clones may acquire further genetic abnormalities, e.g. to allow them to further expand or compete for stromal niches within the bone marrow, such that within an individual patient, multiple genetically distinct clones may be present. (wikilite.com)
- Prerequisite for its evolution is heritable genetic variation. (uni-konstanz.de)
- While many of the genetic and epigenetic abnormalities in neoplasms are probably neutral evolution , many have been shown to increase the proliferation of the mutant cells, or decrease their rate of death ( apoptosis ). (wikipedia.org)
- Modern descriptions of biological evolution will typically elaborate on major contributing factors to evolution such as the formation of local micro-environments, mutational robustness, molecular degeneracy , and cryptic genetic variation. (wikipedia.org)
- The clonal diversity, genetic diversity and structure of Heliconia angusta (Heliconiaceae) were assessed using AFLP-markers. (cambridge.org)
- The effects of germline genetic context on the selective pressures driving somatic clonal evolution are explored. (cdc.gov)
- Elucidation of the molecular and genetic pathways driving clonal evolution may inform surveillance and risk stratification, and may lead to the development of novel therapeutic strategies. (cdc.gov)
- As the HUMARA assay is based on the epigenetic state of cells, the underlying genetic determinants of the clonal expansion remained to be uncovered. (wikipedia.org)
- To differentiate between genetic and epigenetic changes, we are using a novel method that allows us to obtain genotypic and transcriptomic data from the same single cell, allowing us to trace clonal expansions that are mainly driven by epigenetic factors as well as those driven by genetic alterations. (ki.se)
- On the other hand, genetic diversity in specific clones of Ph + B-ALL that drive clonal evolution has recently come to light. (wiley.com)
- Clonal hematopoiesis can be detected in a patient's blood or bone marrow by identifying genetic changes (eg, mutations or chromosomal abnormalities) that have developed during an individual's lifetime in a process called clonal evolution. (ashpublications.org)
- The way ants interact is fundamentally different from how solitary organisms interact, and with these findings we know a bit more about the genetic evolution that enabled ants to create structured societies. (rockefeller.edu)
Heterogeneity and clonal evolution3
- Accurate allele frequencies are important for measuring subclonal heterogeneity and clonal evolution. (biomedcentral.com)
- Our method simplifies PCR duplicate identification and emphasizes their removal in studies of tumor heterogeneity and clonal evolution. (biomedcentral.com)
- The challenge in precision medicine has been improving the understanding of cancer heterogeneity and clonal evolution, which has major implications in targeted therapy selection and disease monitoring. (missionbio.com)
Mutation8
- In a study published online today in the New England Journal of Medicine , researchers from the US and Japan described mutation and clonal dynamic patterns in aplastic anemia - a non-cancerous condition involving an immune attack on blood system cells that sometimes progresses to myelodysplastic syndrome and/or acute myeloid leukemia (AML). (genomeweb.com)
- Because the high level of clonal heterogeneity in CLL may be fueled by clonal diversity within earlier B cell lineage cells, we propose to characterize marrow B cell precursors of CLL patients through targeted deep sequencing of patient leukemia specific mutations and integrated analysis of mutation profiling with mRNA expression at the single cell level (Aim 2). (grantome.com)
- Alternatively, clonal hematopoiesis may arise without a driving mutation, through mechanisms such as neutral drift in the stem cell population. (wikipedia.org)
- We have now used clonal stem and progenitor cell assays to show that the impact of a given mutation is dependent on whether it is acquired in a wild-type or a single mutant cell, meaning that the consequences of each mutation are shaped by the effects of the preceding mutation. (ncri.org.uk)
- This new model is not only biologically compelling but also of significant clinical importance as knowledge of mutation order could predict stage of disease or treatment response based on the evolution of the stem cell compartment. (ncri.org.uk)
- As the name suggests, clonal interference occurs in an asexual lineage ("clone") with a beneficial mutation. (wikipedia.org)
- This has to do with the fact that clonal interference also influences another part of the reproductive strategy of a population, namely mutation rate. (wikipedia.org)
- The concept of an "actionable mutation" is considered within a model of clonal dominance and heterogeneous tumor cell dependencies. (aacrjournals.org)
Clones7
- The rate of recombinational replacement and the average size of the replacements are estimated in a set of closely related strains in which a clonal frame is dotted with occasional stretches of DNA belonging to other clones. (genetics.org)
- If common clones are selected against and rare clones gain a concomitant advantage, we expect that clonal turnover should be faster during parasite epidemics than between them. (deepdyve.com)
- We monitored marker frequencies during evolution and measured the competitive fitness of random clones from each marker state after evolution. (genetics.org)
- In the absence of recombination, this may lead to competition between separate clones that each carry different beneficial mutations, a phenomenon called "clonal interference" ( G errish and L enski 1998 ). (genetics.org)
- After evolution, we isolated clones from both marked subpopulations and measured their fitness in competition with the common ancestor. (genetics.org)
- Darwinian evolution and tiding clones in multiple myeloma. (wikilite.com)
- The course of clonal evolution of 2 related clones in the blood of a patient with Waldenstrom macroglobulinemia (WM) indicates the functional importance for the expression of the B-cell receptor for the survival of these malignant cells. (elsevier.com)
Chronic Lymphocy3
- Examination of clonal evolution in chronic lymphocytic leukemia. (cdc.gov)
- Clonal evolution explains unpredictable leukemia disease course By Lynda Williams, Senior medwireNews Reporter Researchers have revealed the complicated clonal evolution of chronic lymphocytic leukemia , giving insight into the variation in disease training course and its own response to treatment. (parkerfirstbaptist.org)
- By applying this analysis approach to 149 chronic lymphocytic leukemia (CLL) cases, we discovered earlier and later cancer drivers, uncovered patterns of clonal evolution in CLL and linked the presence of subclones harboring driver mutations with adverse clinical outcome. (grantome.com)
Lineages5
- dN/dS was originally developed in the context of species evolution using the Wright-Fisher process, a classical population genetics model that assumes that evolution occurs over very long timescales, which permits new mutations to fix within lineages. (elifesciences.org)
- Comparative analysis with 923 GBS genomes belonging to CC1, CC19, and CC23 revealed that the evolution of CC17 is distinct from that of other human-adapted lineages and recurrently targets functions related to nucleotide and amino acid metabolism, cell adhesion, regulation, and immune evasion. (asm.org)
- Validated "hits" that target genes essential for the evolution, maintenance, or persistence of neoplastic cell lineages represent highly favorable candidates for improved therapeutic strategies. (asu.edu)
- The phenomenon of clonal interference also occurs in cancer and pre-cancer cell lineages within a patient. (wikipedia.org)
- A key focus is on the identification of clonal lineages of B-cells undergoing the process of somatic hypermutation in germinal centres and the maturation pathways by which these lineages develop over time. (hindawi.com)
Hematopoiesis of indeterminate potential2
- Clonal hematopoiesis of indeterminate potential, or CHIP, is a common aging-related phenomenon in which hematopoietic stem cells (HSCs) or other early blood cell progenitors contribute to the formation of a genetically distinct subpopulation of blood cells. (wikipedia.org)
- In contrast to other conditions linked to clonal hematopoiesis, such as myelodysplastic syndrome (MDS) or clonal hematopoiesis of indeterminate potential in the elderly, the top alterations in AA are closely related to its immune pathogenesis. (ashpublications.org)
Cancers2
- Testa U, Castelli G, Pelosi E. Lung Cancers: Molecular Characterization, Clonal Heterogeneity and Evolution, and Cancer Stem Cells. (mdpi.com)
- Clonal diversity, the source of ITH, is the characteristics of all cancers and plays a critical role in cancer invasion, metastasis and development of resistance to targeted and non-targeted therapies[ 1-4 ]. (jcmtjournal.com)
Course of clonal evolution1
- Classic prognostic factors, i.e., categorized ZAP70 and CD38 expressions as well as mutations in IGVH and NOTCH1 genes did not influence the course of clonal evolution in the examined group of patients. (cdc.gov)
Studies of clonal evolution1
- Advances in next-generation genome analysis technology, including single nucleotide polymorphism arrays (SNP-A), targeted next-generation sequencing (NGS), whole-exome sequencing (WES), and NGS-based HLA typing, have generated several waves of studies of clonal evolution in AA, uncovering the near-ubiquitous presence of clonal hematopoiesis in the recovering marrow of AA patients. (ashpublications.org)
Patients with clonal evolution2
- In conclusion, in patients with clonal evolution as the sole criterion of disease acceleration, good responses to imatinib are still possible. (bloodjournal.org)
- The patients with clonal evolution died earlier, before reaching remission, that can be connected with heavy initial state and high frequency of relapse. (cytgen.com)
Hematopoietic3
- Myeloproliferative neoplasms (MPNs) are a group of clonal disorders characterized by aberrant hematopoietic proliferation and an increased tendency toward leukemic transformation. (nih.gov)
- Chronic myelogenous leukemia (CML) is a clonal hematopoietic stem cell disorder characterized by a specific chromosomal translocation, t(9;22), resulting in a shortened chromosome 22, commonly referred to as the Philadelphia (Ph) chromosome. (bloodjournal.org)
- 2 Clonal hematopoiesis is defined by a disproportionately large fraction of hematopoietic cells arising from a single stem cell or a multipotent hematopoietic progenitor. (ashpublications.org)
Chromosome7
- Molecular evolution of the Escherichia coli chromosome. (genetics.org)
- In chronic myelogenous leukemia (CML), the development of chromosomal abnormalities in addition to the Philadelphia chromosome (clonal evolution) is considered by many to be a feature of accelerated phase (AP). (bloodjournal.org)
- 3 We report a patient with the 5q- syndrome , who had resistance to lenalidomide treatment, associated to emergence of clonal evolution involving chromosome. (haematologica.org)
- According to the clonal and parallel evolution models, it is possible that a metastasis suppressor gene(s) for lung cancer is present on chromosome 11p. (aacrjournals.org)
- In this thesis, the clonal evolution of deletions on chromosome 20q (del20q) and TET2, a member of the Ten-Eleven-Translocation (TET) family of genes, were studied. (unibas.ch)
- Clonal chromosome aberrations belong to the most important prognostic and predictive factors in CLL. (cdc.gov)
- Identity of abnormal chromosome structure at diagnosis and relapse of disease can be an evidence of the influence of chemical agent on establishment of some types of evolution of chromosome abnormalities in leukemic cells in AML in children. (cytgen.com)
Progression5
- Gene set enrichment analysis identified clonal enrichment of mutations in pathways involved in transmembrane transport of small molecules (odds ratio [OR] = 1.9), indicating a role for multidrug-resistance mutations in the progression of advanced chemotherapy-treated disease. (ascopost.com)
- Several models of cancer progression, including clonal evolution, parallel evolution, and same-gene models, have been proposed to date. (aacrjournals.org)
- A generally accepted model for tumor progression is the "clonal evolution" model. (aacrjournals.org)
- In cancer research two fundamentally different mechanisms explaining tumor progression currently split the positions: Clonal evolution versus cancer stem cells. (micronaut.ch)
- Clonal evolution is a key feature of cancer progression and relapse. (grantome.com)
Lead to clonal1
- Genomic instability appears to cooperate with Darwinian selection to promote cancer formation through a process in which genomic aberrations occur at accelerated rates, and those alterations that provide a selective growth advantage lead to clonal evolution and expansion. (asu.edu)
Skip1
- 2:53 Skip to 2 minutes and 53 seconds This malignant phenotype is supported by the inherent features of stem cells - self renewal, and clonal expansion. (futurelearn.com)
Presence of clonal1
- 1 Although AA has long been noted for its association with clonal blood disorders paroxysmal nocturnal hemoglobinuria (PNH) and myelodysplastic syndrome (MDS), the nearly ubiquitous presence of clonal hematopoiesis in AA was appreciated only recently, made possible by advances in cytogenetic and sequencing technologies ( Figure 1 ). (ashpublications.org)
Aplastic anemia1
- Acquired aplastic anemia (AA) is an immune-mediated bone marrow aplasia that is strongly associated with clonal hematopoiesis upon marrow recovery. (ashpublications.org)
Tumors8
- Molecular studies performed on lung tumors during treatment have shown the phenomenon of clonal evolution, thus supporting the occurrence of a temporal tumor heterogeneity. (mdpi.com)
- One is "the parallel evolution model," which proposes early occurrence of metastasis and parallel evolution of primary and metastatic tumors ( 13 ). (aacrjournals.org)
- The parallel evolution model has been very applicable to the metastatic pattern of several solid epithelial tumors ( 15 - 17 ). (aacrjournals.org)
- The earliest ideas about neoplastic evolution come from Boveri [8] who proposed that tumors originated in chromosomal abnormalities passed on to daughter cells. (wikipedia.org)
- The clonal genome evolution of the crayfish may also help explain processes in tumors. (eurekalert.org)
- A phenomenon called clonal evolution occurs both in Marmorkrebs and in tumors. (eurekalert.org)
- Currently, NGS has provided a high-resolution snapshot of the oligoclonal composition and evolution within tumors. (grantome.com)
- In 1976, Peter Nowell proposed the clonal evolution model of cancer and applied evolutionary models to understand tumor growth and treatment failure and the phenomenon of increased tumor aggressiveness that occurs during the natural history of advanced solid tumors ( 3 ). (aacrjournals.org)
Beneficial mutations3
- This phenomenon, known as clonal interference, ensures that those beneficial mutations that do achieve fixation are of large effect. (sciencemag.org)
- Gerrish and Lenski ( 4 ) modeled the fate of beneficial mutations by considering clonal interference among them as a major factor. (sciencemag.org)
- He reasoned that the loss of beneficial mutations because of clonal interference inhibits the adaptivity of asexually reproducing species. (wikipedia.org)
Genome3
- Appearance of unbalanced genome in evolution possess an advantage in proliferate activity and can be connected with the answer on chemotherapy. (cytgen.com)
- This can be exemplified by pioneering studies at The Genome Institute leveraging deep, targeted sequencing of single nucleotide variants (SNVs) discovered using whole genome sequencing (WGS) to calculate variant allele frequencies (VAFs) for studying clonal evolution over time. (grantome.com)
- The result, severe deficiencies in the ants' social behaviors and their ability to survive within a colony, both sheds light on a key facet of social evolution and demonstrates the feasibility and utility of genome editing in ants. (rockefeller.edu)
Complexes5
- Of the various clonal complexes (CCs), CC17 is overrepresented in GBS-infected newborns for reasons that are still largely unknown. (asm.org)
- Identification of clonal complexes. (asm.org)
- BURST analysis was used to assign clonal complexes within the Oxford isolate collection. (asm.org)
- For the major clonal complexes, the predicted clonal ancestors are shown in the central ring, SLVs are shown in the middle (solid) ring, and double-locus variants are shown in the outer (dashed) ring. (asm.org)
- Finally, we note a striking excess of nonsynonymous substitutions in comparisons between isolates belonging to the same clonal complex compared to isolates belonging to different clonal complexes, suggesting that the removal of deleterious mutations by purifying selection may be relatively slow. (asm.org)
Cell clonal3
- Deletion of T cell CD98 prevented experimental autoimmune diabetes associated with dramatically reduced T cell clonal expansion. (jimmunol.org)
- Thus, the integrin-binding domain of CD98 is required for Ag-driven T cell clonal expansion in the pathogenesis of an autoimmune disease and may represent a useful therapeutic target. (jimmunol.org)
- T. B. Kepler, "Reconstructing a B-cell clonal lineage. (hindawi.com)
Highly clonal2
- Influx and expansion in the Southern Chilean ocean of a highly clonal V. parahaemolyticus (serotype O3:K6) population from South East Asia caused one of the largest seafood-related diarrhea outbreaks in the world. (biomedcentral.com)
- During the Chilean epidemic, the pandemic strain consisted of a highly clonal population [ 8 ], which reproduced extensively in the Chilean shore lines, and shared its habitat with many other related species. (biomedcentral.com)
Phenomenon4
- Andreieva S.V., Drozdova V.D., Kavardakova N.V. Phenomenon of the evolution of clonal chromosomal abnormalities in childhood acute myeloid leukemia, Tsitol Genet. (cytgen.com)
- Clonal interference is a phenomenon in evolutionary biology, related to the population genetics of organisms with significant linkage disequilibrium, especially asexually reproducing organisms. (wikipedia.org)
- This allows evolution to proceed more rapidly, a phenomenon known as the Hill-Robertson effect. (wikipedia.org)
- When Muller introduced the phenomenon of clonal interference, he used it to explain why sexual reproduction evolved. (wikipedia.org)
Acute1
- Acute myeloid leukaemia: a paradigm for the clonal evolution of cancer? (biologists.org)
Genomic5
- NEW YORK (GenomeWeb) - A public-private team from the US and UK has successfully used exome and targeted amplicon sequencing of tissue biopsies and circulating tumor DNA to characterize the genomic architecture of a breast cancer patient's tumor and track its clonal evolution over time in response to various therapies. (genomeweb.com)
- Using complementary technologies directed at the detection of genomic events that are present in substantial proportions of the clinically relevant CLL disease bulk, we capture aspects of genomic evolution in CLL over time, including increases in the frequency of genomic complexity, specific recurrent aCNAs, and TP53 mutations. (aacrjournals.org)
- Interestingly, although the frequency of acquisition of changes in treated as opposed to untreated CLL was approximately 4-fold higher, the spectrum of genomic and mutational changes was largely similar, suggesting that the above cited and other recurrent genomic aberrations facilitate clonal dominance independent of, but aided by, therapies, and further that their origin is largely therapy independent. (aacrjournals.org)
- Collectively, these results provide insights into clonal evolution underlying ibrutinib relapse and prompt further investigation on genomic abnormalities that have clinical application potential. (bloodadvances.org)
- Clonal evolution and selection of tumor cells can be assessed by examining genomic and proteomic alterations of tumor samples obtained from multiple sites of primary and metastatic sites. (clinicaltrials.gov)
Hypothesis3
- Two popular concepts that attempt to explain this are the cancer stem cell hypothesis and the clonal evolution model. (nih.gov)
- Analysis of the research backing each concept, along with a review of the results of our recent study investigating putative breast cancer stem cells, suggests how the cancer stem cell hypothesis and the clonal evolution model may be involved in generating breast tumor heterogeneity. (nih.gov)
- Overall, parasitism seems to be a strong driver of host clonal turnover, in support of the Red Queen hypothesis. (deepdyve.com)
Peter Nowell1
- Almost 40 years ago, Peter Nowell suggested the clonal evolution cancer model. (futurelearn.com)
Therapeutic4
- New insights into this process challenge us to understand the impact of treatment on clonal evolution and inspire the development of novel prognostic and therapeutic strategies. (nih.gov)
- For all these reasons it is worthy to explore the evolution over time of antibiotic nonsusceptibility and its relation to clonality, since it may have preventive and therapeutic consequences. (asm.org)
- Genes associated with pathways disrupted by selected clonal aberrations in neoplastic genomes in vivo can then be functionally interrogated in RNAi-based assays to evaluate their potential as therapeutic targets. (asu.edu)
- I will discuss some of our recent findings in PDA genomes and the role of clonal behaviors in mediating therapeutic responses. (asu.edu)
Leukemia6
- Ex vivo experimental studies have suggested that the expression of AID in precursor B cells may promote clonal evolution towards leukemia. (cicancer.org)
- In patients who had Richter transformation, we found that the transformed cells were clonal descendants of circulating leukemia cells but continued to undergo evolution and drifts. (bloodadvances.org)
- Clonal evolution explains unpredictable leukemia disease course By Lynda Williams. (parkerfirstbaptist.org)
- We are analyzing primary and relapsed ALL from the same patient, with the aim of determining the clonal structure of the leukemia and characterize the cancer stem cell population in the primary sample of patients which later relapse. (ki.se)
- Examination of the pathophysiology of these diseases has provided interesting insights into not only the hierarchy of leukemia stem cells but also their clonal evolution. (wiley.com)
- The consequent accumulation of new mutations promotes the adaptability of the leukemia, contributing to clonal selection. (oncotarget.com)
Somatic cells2
- Exposures, the constitutive genetics of the host cells, systemic regulators, local regulators and architectural constraints all impinge upon and constrain the evolution of somatic cells. (nih.gov)
- Somatic evolution is the accumulation of mutations and epimutations in somatic cells (the cells of a body, as opposed to germplasm and stem cells ) during a lifetime, and the effects of those mutations and epimutations on the fitness of those cells. (wikipedia.org)
Selective3
- Understanding how selective pressure from chemotherapy directs the evolution of urothelial carcinoma and shapes its clonal architecture is a central biological question with clinical implications. (ascopost.com)
- This study provides the theoretical link between dN/dS values and selective coefficients in somatic evolution, and measures the DFE of mutations in human tissues. (elifesciences.org)
- Transforming dN/dS values to selective coefficients in somatic evolution is an unaddressed problem. (elifesciences.org)
Cancer stem1
- Breast tumor heterogeneity: cancer stem cells or clonal evolution? (nih.gov)
Diversity3
- Forest fragments commonly exhibit suboptimal site conditions, which can result in enhanced clonal reproduction, and a potential reduction in clonal diversity due to increased selfing and inbreeding depression. (cambridge.org)
- Clonal diversity (Pd) of patches was slightly, yet significantly, lower in forest fragments compared with continuous forest. (cambridge.org)
- Elkhorn coral , Acropora palmata, relies heavily on clonal propagation and often displays low genotypic (clonal) diversity. (springer.com)
Tumour1
- We have recently demonstrated in human malignancies that the evolution of a tumour is also influenced by the order in which its mutations are acquired. (ncri.org.uk)
Chromosomal3
- In the decades that followed, cancer was recognized as having a clonal origin associated with chromosomal aberrations. (wikipedia.org)
- This research was aimed at observing clonal evolution in CLL at the chromosomal level, and assessing its clinical significance in relation to selected prognostic factors. (cdc.gov)
- Clonal interference does not only play a role in the fixation of mutations in chromosomal DNA, but it also influences the stability or persistence of extrachromosomal DNA in the form of plasmids. (wikipedia.org)
Proliferation2
- As clonal evolution could allow Bcr-Abl independent proliferation, we analyzed its impact on the outcome of 71 AP patients treated with 600 mg of imatinib mesylate. (bloodjournal.org)
- The integrin-binding domain of CD98 was necessary and sufficient for full clonal expansion, pointing to a role for adhesive signaling in T cell proliferation and autoimmune disease. (jimmunol.org)
Diversification2
- from Niigata University, Japan, has published the article entitled "Clonal Expansion and Diversification of Cancer-Associated Mutations in Endometriosis and Normal Endometrium " in Cell Reports . (endonews.com)
- Examination of the sequence changes at MLST loci during clonal diversification shows that point mutations give rise to new alleles at least 15-fold more frequently than does recombination. (asm.org)
Stem cell3
- Two popular concepts, the clonal evolution model and the cancer stem cell model, attempt to answer how cancer propagates. (futurelearn.com)
- They represent clonal stem cell disorders with an inherent tendency towards leukemic transformation. (unibas.ch)
- To investigate cytogenetic evolution after upfront autologous stem cell transplantation for newly diagnosed myeloma we retrospectively analyzed fluorescence in situ hybridization results of 128 patients with paired bone marrow samples from the time of primary diagnosis and at relapse. (haematologica.org)
Implications2
- Long-term prospective studies are needed to determine the true prognostic implications of clonal hematopoiesis in AA. (ashpublications.org)
- In this review, the implications of "trunk and branch" tumor evolution for drug discovery approaches and emerging evidence that low-frequency somatic events may drive tumor growth through paracrine signaling fostering a tumor ecologic niche are discussed. (aacrjournals.org)
20182
- however this method is broadly limited to somatic evolution in the blood ( Gibson and Steensma, 2018 ) (where it is feasible to take samples from healthy individuals over time) and in rare cases of patients under active surveillance. (elifesciences.org)
- This article provides a brief, but comprehensive, review of our current understanding of clonal evolution in AA and concludes with 3 cases that illustrate a practical approach for integrating results of next-generation molecular studies into the clinical care of AA patients in 2018. (ashpublications.org)
Cytogenetic evolution1
- Our patient showed no erythroid response to lenalidomide and clonal cytogenetic evolution that was unusual in the 5q- syndrome . (haematologica.org)
Neoplasms1
- Specifically, clinical presentation, risk of thrombosis, and clonal evolution are distinct in patients with myeloproliferative neoplasms who acquire JAK2V617F mutations prior to TET2 mutations compared to those that acquire TET2 mutations before JAK2V617F. (ncri.org.uk)
Phenotype1
- The relationship between the clonal hierarchy and phenotype disease over time are discussed. (biomedcentral.com)
Dominance1
- Changes in clonal dominance may be reflected by changes in monoclonal immunoglobulin production. (wikilite.com)
Interference6
- This, together with their potentially large effective population sizes and the fact that their reproduction is not obligately sexual, suggests that clonal interference may play an important role in their adaptive evolution. (sciencemag.org)
- Clonal interference is thus expected to lead to longer fixation times and larger fitness effects of mutations that ultimately become fixed, as well as to a genetically more diverse population. (genetics.org)
- We found that a consequence of clonal interference is that fitness estimates derived from invasion trajectories were less than half the magnitude of direct estimates from competition experiments, thus revealing fundamental problems with this fitness measure. (genetics.org)
- However, most of the available evidence of clonal interference is inferential and indirect support is scarce. (genetics.org)
- The idea of clonal interference was introduced by American geneticist Hermann Joseph Muller in 1932. (wikipedia.org)
- In this way, clonal interference influences the evolutionary dynamics of plasmid-host adaptation, resulting in faster stabilisation of plasmids in a population. (wikipedia.org)
Clinical2
- We used targeted next-generation sequencing (NGS) of 104 genes to detect somatic mutations in a cohort of 197 MPN patients and followed clonal evolution and the impact on clinical outcome. (nih.gov)
- Finally, to define if subclonal mutations are predictive of clinical outcome, we will systematically identify clonal and subclonal mutations in serial samples prospectively collected from 300 subjects enrolled on a landmark phase III clinical trial of frontline fludarabine-based chemotherapy and characterize the dynamic changes in the clonal landscape within individual cases. (grantome.com)
Pathways1
- Chemotherapy-treated urothelial carcinoma is enriched with clonal mutations involving L1 cell adhesion molecule (L1CAM) and integrin signaling pathways. (ascopost.com)
Metastatic spread1
- Branching evolution and metastatic spread are very early events in the natural history of urothelial carcinoma. (ascopost.com)
Progenitor cell1
- The establishment of a clonal population may occur when a stem or progenitor cell acquires one or more somatic mutations that give it a competitive advantage in hematopoiesis over the stem/progenitor cells without these mutations. (wikipedia.org)
Evidence4
- Fifteen patients had clonal evolution alone (AP-CE), 32 had AP features but no evidence of clonal evolution (HEM-AP), and 24 had AP features plus clonal evolution (HEM-AP + CE). (bloodjournal.org)
- The first major evidence for the existence of prevalent clonal hematopoiesis in healthy people was put forth in the 1990s. (wikipedia.org)
- This view gained mechanistic support in 2012 when it was found a number of the women who showed evidence for clonal hematopoiesis through X-inactivation skew also had mutations in the hematologic-malignancy-associated gene TET2. (wikipedia.org)
- Indeed, the evidence from these studies suggests that between 10% and 20% of the population over age 70 have clonal hematopoiesis. (wikipedia.org)
Divergent1
- Divergent (branching) clonal evolution of cancer with topographical separation. (nih.gov)
Isolates2
- Phylogenetic tree and data of clonal complex 4821 Neisseria meningitidis sublineage L44.1 (China CC4821-R1-C/B ) isolates. (cdc.gov)
- New isolates of V. parahaemolyticus that are able to cause diarrhea in humans by ingestion of seafood periodically emerge through their continuous evolution in the ocean. (biomedcentral.com)
48212
- Expansion of quinolone-resistant Neisseria meningitidis clone China CC4821-R1-C/B from sequence type (ST) 4821 clonal complex (CC4821) caused a serogroup shift from serogroup A to serogroup C invasive meningococcal disease (IMD) in China. (cdc.gov)
- In China, the national dissemination of hyperinvasive sequence type (ST) 4821 clonal complex (CC4821) meningococci led to a shift in IMD epidemiology from mostly MenA to predominantly MenC ( 3 , 4 ). (cdc.gov)
Cytogenetics1
- Next-generation sequencing and cytogenetics studies of clonal hematopoiesis in acquired AA. (ashpublications.org)
Hierarchy1
- A clonal hierarchy is described. (genetics.org)