A tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine.
Substances that contain a fused three-ring moiety and are used in the treatment of depression. These drugs block the uptake of norepinephrine and serotonin into axon terminals and may block some subtypes of serotonin, adrenergic, and histamine receptors. However the mechanism of their antidepressant effects is not clear because the therapeutic effects usually take weeks to develop and may reflect compensatory changes in the central nervous system.
Drugs that act principally at one or more sites within the peripheral neuroeffector systems, the autonomic system, and motor nerve-skeletal system. (From Smith and Reynard, Textbook of Pharmacology, 1991, p75)
Compounds with two BENZENE rings fused to AZEPINES.
Compounds that specifically inhibit the reuptake of serotonin in the brain.
Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
A quinolizidine alkaloid isolated from several FABACEAE including LUPINUS; SPARTIUM; and CYTISUS. It has been used as an oxytocic and an anti-arrhythmia agent. It has also been of interest as an indicator of CYP2D6 genotype.
Tricyclic antidepressant similar to IMIPRAMINE, but with more antihistaminic and sedative properties.
Chlorinated analog of AMPHETAMINE. Potent neurotoxin that causes release and eventually depletion of serotonin in the CNS. It is used as a research tool.
Disease or trauma involving a single peripheral nerve in isolation, or out of proportion to evidence of diffuse peripheral nerve dysfunction. Mononeuropathy multiplex refers to a condition characterized by multiple isolated nerve injuries. Mononeuropathies may result from a wide variety of causes, including ISCHEMIA; traumatic injury; compression; CONNECTIVE TISSUE DISEASES; CUMULATIVE TRAUMA DISORDERS; and other conditions.
A bridged-ring tetracyclic antidepressant that is both mechanistically and functionally similar to the tricyclic antidepressants, including side effects associated with its use.
A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.
A serotonin uptake inhibitor that is effective in the treatment of depression.
Loss of consciousness due to a reduction in blood pressure that is associated with an increase in vagal tone and peripheral vasodilation.
The only family of the order SCANDENTIA, variously included in the order Insectivora or in the order Primates, and often in the order Microscelidea, consisting of five genera. They are TUPAIA, Ananthana (Indian tree shrew), Dendrogale (small smooth-tailed tree shrew), Urogale (Mindanao tree shrew), and Ptilocercus (pen-tailed tree shrew). The tree shrews inhabit the forest areas of eastern Asia from India and southwestern China to Borneo and the Philippines.
Drugs used for their effects on serotonergic systems. Among these are drugs that affect serotonin receptors, the life cycle of serotonin, and the survival of serotonergic neurons.
The behavior of performing an act persistently and repetitively without it leading to reward or pleasure. The act is usually a small, circumscribed behavior, almost ritualistic, yet not pathologically disturbing. Examples of compulsive behavior include twirling of hair, checking something constantly, not wanting pennies in change, straightening tilted pictures, etc.
A selective serotonin reuptake inhibitor that is used in the treatment of DEPRESSION and a variety of ANXIETY DISORDERS.
A standard and widely accepted diagnostic test used to identify patients who have a vasodepressive and/or cardioinhibitory response as a cause of syncope. (From Braunwald, Heart Disease, 7th ed)

Negative immunoregulatory effects of antidepressants: inhibition of interferon-gamma and stimulation of interleukin-10 secretion. (1/147)

There is now some evidence that major depression is accompanied by activation of the inflammatory response system. There is also some evidence that antidepressants may suppress the release of cytokines, such as interleukin-1 beta (IL-1 beta) and IL-6 by activated monocytes and IL-2 and interferon-gamma (IFN gamma) by activated T cells. This study was carried out to examine the effects of clomipramine, sertraline, and trazodone on the stimulated production of IFN gamma, a pro-inflammatory cytokine, and IL-10, a negative immunoregulatory cytokine. Whole blood of nine healthy volunteers was stimulated with PHA, 5 micrograms/mL and LPS, 25 micrograms/mL for 72 hr with and without incubation with clomipramine, 10(-6) and 10(-9) M, sertraline, 10(-6) and 10(-8) M, and trazodone, 10(-6) and 10(-8) M. All three antidepressants significantly reduced IFN gamma secretion, whereas clomipramine and sertraline significantly increased IL-10 secretion in culture supernatant. All three antidepressants significantly reduced the IFN gamma/IL-10 ratio. The results suggest that antidepressants, at concentrations in the therapeutical range, have negative immunoregulatory effects through inhibition of IFN gamma and stimulation of IL-10 release.  (+info)

Clomipramine-induced urinary retention in a cat. (2/147)

A 10-year-old, female, spayed shorthair with presumed psychogenic alopecia was treated with clomipramine (1 mg/kg body weight/day). The cat developed urinary retention within 2 days. Clomipramine was discontinued. Clinical signs resolved over the next 7 days. The urinary retention was attributed to the anticholinergic effects of clomipramine.  (+info)

Clomipramine N-demethylation metabolism in human liver microsomes. (3/147)

AIM: To study the effect of cytochrome P-450 (CYP450) inhibitors on clomipramine (Clo) N-demethylation in vitro. METHODS: The kinetic parameters of Clo N-demethylation in human liver microsomes were obtained by the Michaelis-Menten equation. The parameters after pretreatment with putative inhibitors of various CYP450 isoforms were compared with controls. RESULTS: K(m1), K(m2), Vmax1, Vmax2, Vmax1/K(m1), and Vmax2/K(m2) were (0.11 +/- 0.06), (24 +/- 14) mumol.L-1, (114 +/- 47), (428 +/- 188) nmol.g-1.min-1, (1.8 +/- 1.6), and (0.019 +/- 0.005) L.g-1.min-1, respectively. The interindividual variations for the last 4 parameters reached up to 2.5-, 7.3-, 3.4-, and 1.8-fold. At 5 mumol.L-1 of Clo, troleandomycin (Tro), furafylline (Fur), ditiocarb sodium (Dit), and S-mephenytoin (Mep) produced a marked inhibition on Clo N-demethylation while sulfaphenazole (Sul) and quinidine (Qui) had only slight effects. The inhibitory rates by Dit 30, Mep 500, Fur 10, Tro 10, Fur 80, Tro 200 and Fur 80 + Tro 200 mumol.L-1 were 27.0%, 32.9%, 42.8%, 40.5%, 63.9%, 66.4%, and 78.3%, respectively. The IC50 (95% confidence limits) for Fur and Tro were 27.7 (19.1-36.3) and 42.1 (20.9-63.3) mumol.L-1, respectively. CONCLUSIONS: The N-demethylation of Clo exhibited a biphasic behavior. This reaction was mediated mainly by both CYP1A2 and CYP3A4, to a minor extent by CYP2C19 at the low concentration of Clo in vitro.  (+info)

Local treatments of dorsal raphe nucleus induce changes in serotonergic activity in rat major cerebral arteries. (4/147)

BACKGROUND AND PURPOSE: Rat major cerebral arteries seem to receive serotonergic fibers originating from the dorsal raphe nucleus (DRN), but little is known about their function. The aim of our present work was to establish a functional relationship between this brain stem nucleus and the cerebral blood vessels by studying the effects of several treatments in the DRN on cerebrovascular serotonergic activity. METHODS: Serotonin, clomipramine, 8-OH-DPAT, and WAY-100635 were administered in DRN. A stereotaxically localized electrode allowed the electrical stimulation of this brain stem nucleus. Serotonergic activity was appraised in major cerebral arteries, striatum, and hippocampus from 5-hydroxytryptophan accumulation after aromatic L-amino acid decarboxylase inhibition with NSD-1015. RESULTS: Serotonin significantly decreased serotonergic activity in major cerebral arteries and striatum without affecting it in hippocampus. This reduction was blocked by previous injection of WAY-100635 in DRN. Local administration of 8-OH-DPAT or clomipramine elicited an effect similar to that of serotonin, whereas that of WAY-100635 did not modify serotonergic activity in either of the tissues. Electrical stimulation of DRN significantly increased serotonergic activity in major cerebral arteries and striatum but not in hippocampus. CONCLUSIONS: These results confirm the presence of a serotonergic innervation in rat major cerebral arteries functionally related to DRN. 5-HT(1A) receptor activation partly mediates the action of serotonin in DRN. A serotonergic tone acting on these somatodendritic receptors was not clearly found.  (+info)

Recovery of dopamine neuronal transporter but lack of change of its mRNA in substantia nigra after inactivation by a new irreversible inhibitor characterized in vitro and ex vivo in the rat. (5/147)

1. In vitro, the ability of DEEP-NCS {1-[2-(diphenylmethoxy)ethyl]-4-[2-(4-isothiocyanatophenyl)ethyl]- piperazine} to inhibit [3H]-dopamine uptake by rat striatal synaptosomes was concentration-dependent and inversely related to the protein concentration. This inhibition was irreversible and resulted from changes in Vmax and KM. DEEP-NCS was less potent on noradrenaline, serotonin and choline transport. 2. One day after intrastriatal injections of DEEP-NCS (100 and 1000 pmol) in 20% dimethylsulphoxide, moderate decreases in the ex vivo dopamine uptake were observed in synaptosomes obtained from striatum injected with DEEP-NCS or solvent, and the contralateral uninjected striatum. 3. In similar conditions, 300 pmol DEEP-NCS in 45% 2 hydroxypropyl-gamma-cyclodextrin - 0.5% dimethylsulphoxide solution sub-totally reduced ex vivo dopamine uptake and mazindol binding, and moderately decreased choline and serotonin transport. These reductions were specific to DEEP-NCS-injected striata. A clomipramine pretreatment (16 mg kg-1 i.p. 1 h before) was performed in following experiments, since it reduced the DEEP-NCS-elicited decrease in serotonin uptake without affecting other indices. 4. One day after intrastriatal injection, DEEP-NCS elicited similar dose-dependent decreases in ex vivo dopamine uptake and mazindol binding (ID50=6.9-8 ng striatum-1). Changes in KM and Vmax for ex vivo dopamine transport produced by DEEP-NCS disappeared according to similar time-courses. 5. The t(1/2) for transporter recovery was 6. 1 days. This value should correspond to its actual turnover rate in vivo, since no change in transporter mRNA level was observed in substantia nigra ipsilateral to 300 pmol DEEP-NCS-injected striatum. 6. The results indicate that DEEP-NCS behaves as a potent, quite selective, irreversible inhibitor of the DAT, in vitro and in vivo. Its use in vivo suggests that the physiological half-life of the rat striatal DAT is close to 6 days.  (+info)

Citalopram controls phobic symptoms in patients with panic disorder: randomized controlled trial. (6/147)

OBJECTIVE: To examine the effects of long-term treatment with citalopram or clomipramine on subjective phobic symptoms in patients with panic disorder. DESIGN: Double-blind, parallel-group, five-arm study. PATIENTS: Patients aged 18 to 65 years with panic disorder (DMS-III-R diagnosis) and with no major depressive symptoms. INTERVENTIONS: Four hundred and seventy-five patients were randomized to 8 weeks of treatment with either citalopram (10 to 15 mg per day; 20 to 30 mg per day; or 40 to 60 mg per day), clomipramine (60 to 90 mg per day) or placebo. Two hundred and seventy-nine patients continued treatment after the 8-week acute phase. OUTCOME MEASURES: Phobic symptoms were assessed using the Phobia Scale and the Symptom Checklist's (SCL-90) phobia-related factors. RESULTS: At all dosages, citalopram was more efficacious than placebo, with 20 to 30 mg generally being the most effective dosage. Citalopram (20 to 30 mg) generally decreased phobic symptoms significantly more than placebo after Month 3. Interpersonal sensitivity decreased when measured on the respective SCL-90 sub-scale. Alleviation of phobic symptoms generally continued to increase towards the end of the treatment. The effect of clomipramine was not as consistent. CONCLUSIONS: All active treatment groups, especially the group receiving 20 to 30 mg per day of citalopram, effectively controlled phobic symptoms in patients with panic disorder. Long-term treatment with citalopram further decreased phobic symptoms.  (+info)

Effect of clomipramine on monoamine metabolites in the cerebrospinal fluid of behaviorally normal dogs. (7/147)

The tricyclic antidepressant, clomipramine, is an effective treatment for canine compulsive disorder (canine CD). This disorder is a clinical syndrome of abnormal conflict behaviors and its pathophysiology is unknown. However, because clomipramine is an effective treatment, information about the drug's neurochemical effect could enhance the understanding of canine CD. The following experiment used 6 behaviorally normal dogs to assess the effect of clomipramine (3 mg/kg, q24h, PO) on the central turnover of 3 monoamines (serotonin, dopamine, and norepinephrine) as measured by the concentrations of their respective metabolites in cerebrospinal fluid (CSF). In a randomized, placebo-controlled, AB-BA crossover experiment, cisternal CSF was taken after 1, 2, 4, and 6 wk on each treatment. No effect of clomipramine was detected. This contrasts with human studies that have suggested that clomipramine affects the concentrations of monoamine metabolites in lumbar CSF. However, those papers do not address methodological assumptions, such as (i) metabolites in CSF originate only from the brain, and (ii) concentrations of metabolites in cisternal/lumbar CSF reflect the concentrations in local areas of the brain. Notwithstanding the small sample size, our results suggest that more localized sampling techniques (e.g. microdialysis) are needed when examining the effect of drugs on central monoamine metabolites. Clomipramine's efficacy for canine CD indicates the need for neurobiological research and, to our knowledge, our study is the first of its kind in dogs. The resulting data are preliminary but they can inform optimal neurobiological studies of canine CD.  (+info)

Determination of fluoxetine, fluvoxamine, and clomipramine in pharmaceutical formulations by capillary gas chromatography. (8/147)

A simple and fast capillary gas chromatographic method with flame ionization detection is proposed for the simultaneous determination of fluoxetine, fluvoxamine, and clomipramine without a prederivatization. The reported method is the first one that allows the determination of three selective serotonin reuptake inhibitors. Optimal conditions for the quantitative separation were investigated: column head pressure (80 kPa), injector and detector temperatures (260 and 250 degrees C), time and temperature for the splitless step (0.75 min and 60 degrees C), size of sample (2 microL), and oven temperature program, providing analysis times shorter than 10 min. Aspects such as the stability of the solutions, linearity, accuracy, and precision are examined in order to validate this method. Peak purity and detection and quantitation limits are also assessed using mass selective detection. The scope of the validated method is tested in the analysis of pharmaceutical preparations, with recoveries between 97.5 and 102.5% with regard to their nominal contents.  (+info)

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Incubation of LMCAT fibroblasts cells with antidepressants potentiates glucocorticoid receptor (GR)-mediated gene transcription in the presence of cortisol, but not of corticosterone. We have suggested that antidepressants do so by inhibiting the LMCAT cells membrane steroid transporter and thus by increasing cortisol intracellular concentrations. We now confirm and extend this model to primary neuronal cultures. Clomipramine, a tricyclic antidepressant, increased the intracellular accumulation of 3H-cortisol, but not 3H-corticosterone, in LMCAT cells (+80%) and primary rat neurones (+20%). The latter finding is the first demonstration that a membrane steroid transporter is present in neurones. Moreover, verapamil, a membrane steroid transporter inhibitor, reduced the effects of clomipramine on the intracellular accumulation of 3H-cortisol in LMCAT cells. Finally, clomipramine also decreased GR expression (whole-cell Western blot) in LMCAT cells (50% reduction) and primary rat neurones (80% reduction).
Do not take clomipramine with a monoamine oxidase (MAO) inhibitor (eg, isocarboxazid [Marplan®], linezolid (Zyvox®), methylene blue, phenelzine [Nardil®], selegiline [Eldepryl®], tranylcypromine [Parnate®]). Do not start taking clomipramine during the 2 weeks after you stop a MAO inhibitor and wait 2 weeks after stopping clomipramine before you start taking a MAO inhibitor. If you take them together or do not wait 2 weeks, you may develop confusion, agitation, restlessness, stomach or intestinal symptoms, a sudden high body temperature, an extremely high blood pressure, or severe convulsions. Clomipramine may cause a serious condition called serotonin syndrome if taken together with some medicines. Do not use clomipramine with buspirone (Buspar®), fentanyl (Abstral®, Duragesic®), lithium (Eskalith®, Lithobid®), tryptophan, St. Johns wort, or some pain or migraine medicines (eg, sumatriptan, tramadol, Frova®, Maxalt®, Relpax®, Zomig®). Check with your doctor first before taking any ...
Background: Controlled trials suggest that clomipramine may be a highly effective antipanic drug. Lowering the starting dose may alleviate troublesome initial side effects and increase acceptability and compliance.. Method: Fifty-eight patients with DSM-III-R panic disorder with or without agoraphobia underwent 13 weeks of clomipramine treatment. Starting at 10 mg/day, the dose was gradually increased to a mean dose of 97 mg/day.. Results: While completers showed highly significant improvement, the benefits were severely limited by a high dropout rate due to adverse reactions occurring mostly during the first 2 weeks of treatment. Conclusion: Given the alternatives, clomipramine should not be used as a first-line antipanic medication. ...
To the best of our knowledge, there are no case studies of serotonin syndrome (SS) in patients with autism spectrum disorder. We report the case of a 33-year-old male who presented SS under the combined use of clomipramine and risperidone. More specifically, within 2 days after clomipramine (10 mg/BID-two times a day) was added to risperidone (4 mg/OD-once a day), mirtazapine 45 mg/OD and alprazolam (0,5 mg/TID-three times a day) he began to present mental, neurological and autonomic symptoms. All his psychopathological manifestations and laboratory findings normalized after the above-mentioned drugs discontinuation, and the administration of supportive medical care and lorazepam 2,5 mg/TID. The diagnosis of serotonin syndrome was challenging due to the relatively low dose of clomipramine, an increase of risperidone which had taken place before clomipramine administration and clinical symptoms which could be attributed to both serotonin and neuroleptic malignant syndrome.
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Administration of a TCA, such as clomipramine, which has the potential to cause hypothyroidism, may exacerbate behavioral signs or reduce the benefit of the drug. It has been shown in humans that a decrease in thyroid function can be associated with depression, and that supplementation of thyroxine or T3 as an adjunct to refractory depression has been shown to be beneficial. Although similar results have not been demonstrated in the dog, the authors did not recommend thyroxine supplementation. However, it would be prudent to monitor thyroid function tests, in addition to performing physical examinations and bloodwork, including CBC, serum biochemical profile, urinalysis, both prior to and during clomipramine administration, in order to ensure that hypothyroidism is neither misdiagnosed, nor that it subsequently occurs ...
ClomiPramine Hydrochloride treat obsessive-compulsive disorders and may be useful for separation anxiety and aggression. Clomipramine may also be prescribed for other behavioral problems in conjunction with behavior modification. Clomipramine come in capsule form.
My doctor wants me to try imipramine, but everything I read points to clomipramine being superior. I suffer mainly from extreme anxiety (psych thinks I have anxious depression) and some depression. Not really any OCD, although when my anxiety is high, I have OCD thoughts. I dont want to start imipramine, only to wish I started clomipramine. The side effects of imipramine seem to be worse than clomipramine. Any help would be appreciated (hopefully you could help me PDU)? Other meds
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RATIONALE: A 44-base-pair insertion/deletion polymorphism in the promoter region of the human serotonin (5-HT) transporter (5-HTT) gene gives rise to a bi-allelic polymorphism designated long (l) and short (s). The s variant is associated with a lower expression of 5-HTT sites and a reduced efficiency of 5-HT reuptake. OBJECTIVE: The aim of the present study was to determine whether the increase in brain 5-HT function produced by acute 5-HT reuptake blockade is influenced by the 5-HTT promoter l/s polymorphism. METHODS: We measured the increase in plasma prolactin that follows acute administration of the tricyclic antidepressant clomipramine as an index of 5-HT neurotransmission in 14 healthy female subjects (7 with ss genotype and 7 with ll genotype) using a placebo-controlled crossover design. RESULTS: Clomipramine-induced prolactin release was significantly greater in subjects with the ll genotype. CONCLUSION: Our findings suggest that acute 5-HT reuptake blockade produces a greater increase in 5-HT
Buy Clomipramine Online! Clomipramine Capsules USP is indicated for the treatment of obsessions and compulsions in patients with Obsessive-Compulsive Disorder (OCD). Compulsions are repetitive, purposeful, and intentional behaviors performed in response to an obsession or in a stereotyped fashion, and are recognized by the person as excessive or unreasonable.
Clomipramine is a prescription drug licensed for the treatment of obsessive-compulsive disorder. This eMedTV article explains how clomipramine works, describes some potential side effects, and outlines some tips for when and how to take this medication.
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Mu-opioid agonists are effective analgesics but have undesirable effects such as sedation and abuse liability that limit their clinical effectiveness. Serotonergic systems also modulate nociception, and serotonin uptake inhibitors may be useful as adjuncts to enhance analgesic effects and/or attenuate undesirable effects of mu agonists. This study examined effects of the serotonin uptake inhibitor clomipramine on behavioral effects produced in rhesus monkeys by mu agonists with varying efficacy at mu receptors (nalbuphine,morphine,methadone). Clomipramine and each mu agonist were studied alone and in fixed-proportion mixtures in assays of schedule-controlled responding, thermal nociception and capsaicin-induced thermal allodynia. In the assay of schedule-controlled responding, all mu agonists dose-dependently decreased response rates. Clomipramine was inactive alone and did not alter effects of mu agonists. In the assay of thermal nociception, all mu agonists produced dose-dependent ...
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Clomipramine is a leading tricyclic antidepressant that is commonly used in the treatment of Obsessive-Compulsive Disorder (OCD) and other phobia disorders. The active ingredient in Anfranil®, ...
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Clomipramine is a tricyclic antidepressant (TCA). It is thought to work in the brain by increasing the activity of the chemical serotonin. This medicine is available only with your doctors prescription. This product is available in the following dosage forms:. ...
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Clomipramine oral capsule is a prescription medication used to treat the excessive and repetitive ideas, thoughts, and impulses of obsessive-compulsive disorder. Its available as a generic drug and as the brand-name drug Anafranil. Learn about side effects, warnings, dosage, and more for clomipramine.
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Clomipramine is a derivative of imipramine with a chlorine atom added to one of its rings and is also known as 3-chloroimipramine. It is a tertiary amine
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Clomipramine is used in dogs to treat behavior problems such as separation anxiety and excessive barking. Come to petMD for a complete list of pet medications and prescriptions.
After the first dose, the owner noticed the medication made the cat too sleepy and the. Fifty one dogs with CCD were given clomipramine 3 mg/kg 1.3 mg/lb
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In my experience there have been absolutely no downsides to drinking whilst taking anti-depressants. In my time Ive taken Clomipramine (Anafranil), Venlafaxine (Effexor), Citalopram (Celexa?), Mirtazapine (Remeron), another I forget, and now Im back on Clomipramine and have been solidly for the last 6 years. Unlike antibiotics where indeed alcohol consumption can nullify the effects of the antibiotic, usually the only warning as such with anti-depressants is that they may cause alcohol to be more effective. I.e. You dont need to drink as much for the same buzz. However in my personal experience, its better than that. Ive always found that the drunkeness I get when drinking on AD is a much more refined experience than drinking without. I get all the sociability, fun etc, but with much more clarity...(Perhaps that due also to drinking vodka-redbulls..). I first took Clomipramine seriously when I was 30 years of age and the window it opened onto how normal felt, meant the very first thing I ...
The aim of the study was to identify the cytochrome P450s (CYPs) that catalyze the biotransformation of clomipramine in vitro. A high-performance liquid chromatography method was developed to assay N-desmethylclomipramine, 8-hydroxyclomipramine, 2-hydroxyclomipramine, 8-hydroxydesmethhylclomipramine, didesmethylclomipramine and 2-hydroxydesmethylclomipramine formed by microsomes prepared from human liver and yeast expressing human CYP1A1, 1A2, 2C8, 2C9, 2C18, 2C19, 2D6 and 3A4. There was a statistically significant correlation between the formation rate of desmethylclomipramine and the immunoquantified concentration of CYP3A4 in 12 human liver microsome preparations (rs = 0.664, P = .028). Ketoconazole was a very potent inhibitor of desmethylclomipramine formation (Ki = 0.054 microM) and microsomes from yeast expressing CYP3A4 were also active in forming the metabolite (formation rate: 25.6 nmol/nmol of CYP per hr). Thus, the results are consistent with the assumption that the N-demethylation of ...
The serotonin transporter (SERT) controls synaptic serotonin levels and is the primary target for antidepressants, including selective serotonin reuptake inhibitors (e.g. (S)-citalopram) and tricyclic antidepressants (e.g. clomipramine). In addition to a high affinity binding site, SERT possesses a low affinity allosteric site for antidepressants. Binding to the allosteric site impedes dissociation of antidepressants from the high affinity site, which may enhance antidepressant efficacy. Here we employ an induced fit docking/molecular dynamics protocol to identify the residues that may be involved in the allosteric binding in the extracellular vestibule located above the central substrate binding (S1) site. Indeed, mutagenesis of selected residues in the vestibule reduces the allosteric potency of (S)-citalopram and clomipramine. The identified site is further supported by the inhibitory effects of Zn(2+) binding in an engineered site and the covalent attachment of ...
Generic Anafranil is a tricyclic antidepressant. Generic Anafranil is used to treat symptoms of obsessive-compulsive disorder (recurrent thoughts or feelings and repetitive actions). Generic Anafranil works by affecting chemicals in the brain that may bec
CLOMIPRAMINE 29. CLOREXADOL 30. CLORPROMAZINE 31. CHLOROPROXENE 32. CLOTIAPINE 33. CLOZAPINE 34. DEANOL 35. DESFLURANO 36. ...
Anafranil (clomipramine) - a tricyclic antidepressant; mostly used to treat OCD. Aricept (donepezil) - used to slow the ...
If the patient wishes to have a sedative effect then clomipramine is prescribed. The effect of these drugs is to suppress the ... "Clomipramine 10 mg Capsules, Hard". Medicines.org.uk. Retrieved 19 April 2021. "Anafranil Tablets". NPS MedicineWise. Retrieved ... In clinical practice, venlafaxine (doses 75-225 mg daily) or clomipramine (25-100 mg daily) are the most common antidepressants ... Venlafaxine is a norepinephrine and serotonin reuptake inhibitor whereas clomipramine is a tricyclic antidepressant. Their ...
Tricyclic antidepressants, e.g. amitriptyline, clomipramine. Additive effect. Adrenergic decongestants, e.g. phenylephrine. ...
Clomipramine Luscombe GP, Buckett WR (1993). "Pharmacology of Cyanodothiepin (BTS 56 424), a Selective 5-Hydroxytryptamine ...
Vallejo, J.; Olivares, J.; Marcos, T.; Bulbena, A.; Menchón, J. M. (2 January 2018). "Clomipramine versus Phenelzine in ...
Wirz-Justice, Anna; Pühringer, Wolfgang; Hole, Günter (October 1976). "Sleep Deprivation and Clomipramine in Endogenous ...
Vallejo J, Olivares J, Marcos T, Bulbena A, Menchón JM (November 1992). "Clomipramine versus phenelzine in obsessive-compulsive ...
It is described as being associated with minimal or no orthostatic hypotension, at least in comparison to clomipramine, in ... Other dibenzazepine TCAs include imipramine, desipramine, and clomipramine. Trimipramine is a derivative of imipramine with a ... Other tertiary amine TCAs include amitriptyline, imipramine, clomipramine, dosulepin (dothiepin), and doxepin. The chemical ... clomipramine, desipramine, doxepin, imipramine, and trimipramine) were identified. Common adverse effects include: Sedation - ...
Clomipramine and calcium channel blockers have been tried. While the frequency of the condition is not well studied, some have ... with clomipramine, flunarizine, nifedipine, topiramate, carbamazepine. Studies suggest that education and reassurance can ...
Specific antidepressants that have been used include clomipramine. Psychotherapies that have been used for ORS include ...
With respect to tricyclic antidepressants, only clomipramine and imipramine have a risk of causing SS. Many medications may ... 2008). "Serotonin syndrome caused by olanzapine and clomipramine". Minerva Anestesiol. 74 (1-2): 41-5. PMID 18004234. Archived ...
Clomipramine - (trademarked as Anafranil) is a tricyclic antidepressant (TCA). Fluvoxamine - (brand name Luvox) is an ...
Other dibenzazepine TCAs include imipramine, desipramine, clomipramine, and trimipramine. Lofepramine is a tertiary amine TCA, ...
Clomipramine Dog behavior Dog health "Reducing Fear in Your Dog". Amy Shojai (2018), "Music Therapy", Dog Facts: The Pet ... The website for Clomicalm (Clomipramine Hydrochloride) states it does not alter a dog's personality or sedate it, but does list ... Commonly used medications include: Diazepam Clorazepate Alprazolam Amitriptyline Clomipramine Fluoxetine Melatonex (Melatonin) ...
Other tertiary amine TCAs include amitriptyline, imipramine, clomipramine, doxepin, and trimipramine. Dosulepin exhibits (E) ...
Amitriptyline, imipramine, lofepramine and clomipramine are tricyclic antidepressants and tertiary amines. Nortriptyline, ...
Antidepressants are most commonly used, including doxepin, amitriptyline, fluoxetine, and clomipramine. If the psychological ...
This theory is compatible with two studies on lipid rescue for clomipramine toxicity in rabbits and with a clinical report on ... Harvey M, Cave G (February 2007). "Intralipid outperforms sodium bicarbonate in a rabbit model of clomipramine toxicity". ... Harvey M, Cave G, Hoggett K (February 2009). "Correlation of plasma and peritoneal diasylate clomipramine concentration with ...
Other tertiary amine TCAs include amitriptyline, imipramine, clomipramine, dosulepin (dothiepin), and trimipramine. Doxepin is ...
Clomipramine was a predecessor to the development of the more recent SSRIs. There was, in fact, a time prior to the SSRIs when ... Inserting a chlorine atom into imipramine leads to clomipramine, a drug that is much more SERT selective than the parent ...
Treatment with clomipramine, a tricyclic antidepressant, was shown in a small double-blind study to improve symptoms, but ... The medication clomipramine may also be helpful, as will keeping fingernails clipped. Trichotillomania is estimated to affect ... Swedo SE, Leonard HL, Rapoport JL, Lenane MC, Goldberger EL, Cheslow DL (1989). "A double-blind comparison of clomipramine and ... results of other studies on clomipramine for treating trichotillomania have been inconsistent. Naltrexone may be a viable ...
Results of an open pilot study versus clomipramine with or without levomepromazine]". Drugs (in French). 53 (Suppl 2): 34-39. ...
Other tertiary amine TCAs include amitriptyline, clomipramine, dosulepin (dothiepin), doxepin, and trimipramine. The chemical ... Other dibenzazepine TCAs include desipramine (N-desmethylimipramine), clomipramine (3-chloroimipramine), trimipramine (2′- ...
Comparative efficacy of paroxetine is equivalent to that of clomipramine and venlafaxine. Paroxetine is also effective for ...
At the time of her suicide, Dann was taking an unlicensed drug, clomipramine. The effects of this drug were initially ... She had already begun taking clomipramine, a drug for OCD, and her new psychiatrist increased the dosage, adding lithium ...
For severe depression, sertraline is as good as clomipramine but is better tolerated. Sertraline appears to work better in ... and mianserin and is similar to the tricyclic antidepressants such as amitriptyline and clomipramine. In the treatment of ... clomipramine, imipramine, clonazepam, alprazolam, and fluvoxamine) indicates approximate equivalence of these medications. ... performed better than the gold standard of OCD treatment clomipramine. Continuing sertraline treatment helps prevent relapses ...
Other tertiary amine TCAs include amitriptyline, imipramine, clomipramine, dosulepin (dothiepin), doxepin, and trimipramine. ...
... clomipramine and neuroleptics in phenotyped patients". Pharmacol Res. 31 (6): 347-53. doi:10.1016/1043-6618(95)80088-3. PMID ...
The study found that after one month of daily administration of the tricyclic anti-depressant clomipramine, these compulsive ... These results suggest that clomipramine can be beneficial to canines displaying anxiety behaviors. Fluoxetine, an SSRI used by ... In a study using the anti-depressant clomipramine, nine dogs underwent withdrawal after discontinuing treatment. Five of those ... The study found that after one month of daily administration of the tricyclic anti-depressant clomipramine, these compulsive ...
Clomipramine: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Clomipramine comes as a capsule to take by mouth. At the beginning of treatment, clomipramine is usually taken three times a ... Continue to take clomipramine even if you feel well. Do not stop taking clomipramine without talking to your doctor. If you ... Before taking clomipramine,. *tell your doctor and pharmacist if you are allergic to clomipramine, other tricyclic ...
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
combined clomipramine ( Anafranil ) and SSRIs in the treatment of adolescent OCD. ... Clomipramine (Anafranil) : structure. Clomipramine (Anafranil) and SSRIs for OCD. Clomipramine (Anafranil): prescribing ... One clomipramine responder was subsequently followed in open maintenance treatment with clomipramine for 4 years, and her ... disorder with clomipramine by. Simeon D, Stein DJ, Hollander E. Department of Psychiatry, Mount Sinai School of Medicine,. New ...
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DG00929 Clomipramine. D07727 Clomipramine. DG01644 CYP2D6 substrate. DG00929 Clomipramine. D07727 Clomipramine. DG01633 CYP3A/ ... DG00929 Clomipramine. D00811 Clomipramine hydrochloride. DG01639 CYP2C19 substrate. DG00929 Clomipramine. D00811 Clomipramine ... DG00929 Clomipramine. D07727 Clomipramine. DG01728 Tricyclic antidepressant. DG00929 Clomipramine. D07727 Clomipramine. ... DG00929 Clomipramine. DG01639 CYP2C19 substrate. DG00929 Clomipramine. DG01644 CYP2D6 substrate. DG00929 Clomipramine. DG01633 ...
Drug: Clomipramine Hydrochloride 25 mg Capsules (Geneva Pharmaceuticals). Active Comparator: 2 Anafranil Clomipramine ... Drug: Clomipramine Hydrochloride 25 mg Capsules (Geneva Pharmaceuticals) Drug: Anafranil Clomipramine Hydrochloride 25 mg ... Clomipramine. Antidepressive Agents, Tricyclic. Antidepressive Agents. Psychotropic Drugs. Serotonin Uptake Inhibitors. ... To Demonstrate the Relative Bioavailability of Geneva and Basel (Anafranil) 25 mg Clomipramine Hydrochloride Capsules Under ...
... chemotherapeutic effects of clomipramine in mice infected with an isolate obtained from an endemic area. - H W Rivarola, J M ... Trypanosoma cruzi: chemotherapeutic effects of clomipramine in mice infected with an isolate obtained from an endemic area.. ... These results demonstrate that clomipramine, clinically used as a neuroleptic, could be a promising trypanocidal agent for the ... We investigated whether clomipramine, a tricyclic antidepressant drug with anti-trypanothione reductase and anti-calmodulin ...
The cortisol response to 5-HTP was significantly increased following clomipramine treatment, suggesting that clomipramine, like ... However, facilitation of neurotransmission at 5-HT2 receptors could account for the efficacy of clomipramine and SSRIs in the ... The cortisol response to 5-HTP was significantly increased following clomipramine treatment, suggesting that clomipramine, like ... Clomipramine enhances the cortisol response to 5-HTP: implications for the therapeutic role of 5-HT2 receptors. ...
Clomipramine is used to treat obsessive compulsive disorder (OCD). ... Other medications can affect the removal of clomipramine from your body, which may affect how clomipramine works. Examples ... Before using clomipramine, tell your doctor or pharmacist of all the drugs you take and if you have any of the following ... Before taking clomipramine, tell your doctor or pharmacist if you are allergic to it; or to other tricyclic antidepressants (e. ...
... as well as in the nematode Caenorhabditis elegans exposed to clomipramine. Together, our findings indicate that clomipramine ... as well as in the nematode Caenorhabditis elegans exposed to clomipramine. Together, our findings indicate that clomipramine ... The tricyclic antidepressant clomipramine inhibits neuronal autophagic flux. CAVALIERE, Federica;Fornarelli, Alessandra;Bertan ... In this regard, it was previously demonstrated that clomipramine, a widely used FDA-approved tricyclic antidepressant, ...
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This medicine may be habit-forming. If you or your child feel that the medicine is not working as well, do not use more than your prescribed dose. Call your doctor for instructions. Using narcotics for a long time can cause severe constipation. To prevent this, your doctor may direct you or your child to take laxatives, drink a lot of fluids, or increase the amount of fiber in the diet. Be sure to follow the directions carefully, because continuing constipation can lead to more serious problems. Dizziness, lightheadedness, or fainting may occur when you or your child get up suddenly from a lying or sitting position. Getting up slowly may help lessen this problem. Also, lying down for a while may relieve the dizziness or lightheadedness. This medicine may make you dizzy, drowsy, confused, or disoriented. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or not alert. Before having any kind of surgery ...
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SSRIs or clomipramine should be advanced as tolerated to a therapeutic dose. Clinical response may take 6-10 weeks to become ... Clomipramine is FDA approved to treat obsessions and compulsions in OCD. It is a dibenzazepine compound belonging to family of ... SSRIs are generally preferred over clomipramine in treating OCD. The adverse effect profiles of SSRIs are less prominent, so ... Clomipramine affects serotonin uptake, while it affects norepinephrine uptake when converted into its metabolite ...
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How to use Clomipramine HCL. Read the Medication Guide provided by your pharmacist before you start taking clomipramine and ... To lessen side effects such as stomach upset, clomipramine may be started at a low dose, given in several doses during the day ... Clomipramine is used to treat obsessive compulsive disorder (OCD). It helps decrease persistent/unwanted thoughts (obsessions ... Anxiety symptoms may temporarily worsen when you first start taking clomipramine. If any of these effects persist or worsen, ...
Clomipramine is a dibenzazepine compound belonging to the TCA family. It inhibits the membrane pump mechanism responsible for ... Clomipramine ameliorates adventitious movements and compulsions in prepubertal boys with autistic disorder and severe mental ... Clomipramine affects serotonin uptake and affects norepinephrine uptake when converted into its metabolite, ...
Capsule-shape and has been identified as Clomipramine Hydrochloride 75 mg. It is supplied by Alembic Pharmaceuticals Inc. ... Clomipramine Hydrochloride. Imprint. A 287. Strength. 75 mg. Color. Yellow & White. Shape. Capsule-shape. Availability. ... A 287 (Clomipramine Hydrochloride 75 mg). Pill with imprint A 287 is Yellow & White, Capsule-shape and has been identified as ... Clomipramine is used in the treatment of obsessive compulsive disorder and belongs to the drug class tricyclic antidepressants ...
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Clomipramine from clomipramine hydrochloride capsules is as bioavailable as clomipramine from a solution. The bioavailability ... Clomipramine hydrochloride (N=46). Placebo (N=44). * Events reported by at least 1% of clomipramine hydrochloride patients are ... Use of Clomipramine Hydrochloride With Other MAOIs, Such as Linezolid or Methylene Blue. Do not start clomipramine ... Clomipramine Hydrochloride Capsules, USP Clomipramine hydrochloride capsules, USP 25 mg are orange opaque cap & white opaque ...
Clomipramine. Clomipramine is a tricyclic antidepressant (TCA), prescribed for obsessive-compulsive disorder. ...
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A Scientific Study On The Comparison Of The Interaction Between Clomipramine And Alcohol Or Moclobemide. ... 1. Always take Clomipramine as your doctor or pharmacist has directed.. 2. Do NOT take clomipramine if you have any of the ... 01 Can I consume alcohol after taking Clomipramine?. It is best to wait until all traces of Clomipramine have left your system ... 02 Does Clomipramine cause weight gain?. Patients who get long-term treatment with the tricyclic antidepressant Clomipramine ...
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What is Clomicalm (clomipramine hydrochloride)?. Clomicalm (clomipramine) is used to treat separation anxiety in dogs in ... What is Clomicalm (clomipramine hydrochloride)?. Clomicalm (clomipramine) is used to treat separation anxiety in dogs in ... There is no specific antidote for clomipramine. People with known hypersensitivity to clomipramine should administer the ... There is no specific antidote for clomipramine. People with known hypersensitivity to clomipramine should administer the ...
Clomipramine was therefore tested for neuroleptic activity. Clomipramine and imipramine were ineffective in inhibiting the ... Clomipramine, a new antidepressant, differs from imipramine by having chlorine in position 3 of the aromatic ring and in this ... Experimental evaluation of the possible neuroleptic activity of clomipramine. Indian Journal of Physiology and Pharmacology. ... In contrast to chlorpromazine, clomipramine like imipramine was found to enhance methamphetamine-induced stereotyped behaviour ...
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Brand: Clomipramine Availability: In Stock Average delivery time: 9 Days Exp. Date: December 2025 View product image ... Anafranil (Clomipramine). THE USE OF THE MEDICINE. Anafranil is used to treat obsessive-compulsive disorder (OCD). It can also ...
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  • Anyone considering the use of clomipramine hydrochloride or any other antidepressant in a child, adolescent, or young adult must balance this risk with the clinical need. (nih.gov)
  • Clomipramine hydrochloride capsules, USP is an antiobsessional drug that belongs to the class (dibenzazepine) of pharmacologic agents known as tricyclic antidepressants. (nih.gov)
  • Clomipramine hydrochloride is available as capsules of 25, 50, and 75 mg for oral administration. (nih.gov)
  • Clomipramine hydrochloride, USP is a white to off-white crystalline powder. (nih.gov)
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  • Clomipramine from clomipramine hydrochloride capsules is as bioavailable as clomipramine from a solution. (nih.gov)
  • After multiple daily doses of 150 mg of clomipramine hydrochloride, steady-state maximum plasma concentrations range from 94 ng/mL to 339 ng/mL (mean, 218 ng/mL) for clomipramine and from 134 ng/mL to 532 ng/mL (mean, 274 ng/mL) for desmethylclomipramine. (nih.gov)
  • At a dose of clomipramine hydrochloride 200 mg, subjects who had a single blood sample taken approximately 9 to 22 hours, (median 16 hours), after the dose had plasma concentrations of up to 605 ng/mL for clomipramine, 781 ng/mL for desmethylclomipramine, and 1386 ng/mL for both. (nih.gov)
  • What is Clomicalm (clomipramine hydrochloride)? (1800petmeds.com)
  • Clomipramine, a new antidepressant, differs from imipramine by having chlorine in position 3 of the aromatic ring and in this respect resembles chlorpromazine. (who.int)
  • Clomipramine and imipramine were ineffective in inhibiting the traction response and pinna reflex in mice and in inducing catalepsy in rat. (who.int)
  • In contrast to chlorpromazine, clomipramine like imipramine was found to enhance methamphetamine-induced stereotyped behaviour. (who.int)
  • Thus clomipramine like imipramine possesses negligible neuroleptic activity. (who.int)
  • Imipramine has less sedative and anticholinergic effects than the tertiary amine TCAs, amitriptyline and clomipramine. (drugbank.com)
  • Clomipramine is in a group of medications called tricyclic antidepressants. (medlineplus.gov)
  • Clomipramine is used in the treatment of obsessive compulsive disorder and belongs to the drug class tricyclic antidepressants . (drugs.com)
  • Do not use in dogs with a known hypersensitivity to clomipramine or other tricyclic antidepressants, or in breeding male dogs. (1800petmeds.com)
  • 0.02) and the tricyclic antidepressants amitriptyline and clomipramine (HR? (cdc.gov)
  • Children younger than 18 years of age should not normally take clomipramine, but in some cases, a doctor may decide that clomipramine is the best medication to treat a child's condition. (medlineplus.gov)
  • You should know that your mental health may change in unexpected ways when you take clomipramine or other antidepressants even if you are an adult over age 24. (medlineplus.gov)
  • Take clomipramine exactly as directed. (medlineplus.gov)
  • Continue to take clomipramine even if you feel well. (medlineplus.gov)
  • If you take clomipramine and alcohol together, some adverse effects may worsen, or the drug may stop working as it should. (practicalanxietysolutions.com)
  • Can You Take Clomipramine And Alcohol Together? (practicalanxietysolutions.com)
  • How to take clomipramine It is usual to take clomipramine once a day at bedtime, although it can also be taken in smaller doses two or three times a day. (alltabsonline.com)
  • A small number of children, teenagers, and young adults (up to 24 years of age) who took antidepressants ('mood elevators') such as clomipramine during clinical studies became suicidal (thinking about harming or killing oneself or planning or trying to do so). (medlineplus.gov)
  • METHODS: Eight subjects with DSM-III-R depersonalization disorder were entered into a double-blind crossover trial consisting of 8 weeks desipramine and 8 weeks clomipramine. (biopsychiatry.com)
  • Do not have Clomipramine if you are allergic to it or any other anti-depressant drug such as amitriptyline, desipramine, doxepin, amoxapine, trimipramine. (daynightdrugs.com)
  • Read the Medication Guide provided by your pharmacist before you start taking clomipramine and each time you get a refill. (blinkhealth.com)
  • Anxiety symptoms may temporarily worsen when you first start taking clomipramine. (blinkhealth.com)
  • For these reasons, before you start taking clomipramine it is important that your doctor knows: If you are pregnant or breast-feeding. (alltabsonline.com)
  • We used Swedish national registry data 2005-2017 on dispensed medications and inpatient care to estimate risks for early-treatment persistence, treatment discontinuation, switching to a new antidepressant medication, and mania within 3 months of treatment initiation in patients treated with citalopram, escitalopram, sertraline, amitriptyline, and clomipramine. (cdc.gov)
  • In this study, we undertook to evaluate the efficacy of the potent serotonin reuptake inhibitor clomipramine in treating depersonalization. (biopsychiatry.com)
  • Compared to other TCAs and S-RIs, clomipramine is a serotonin reuptake inhibitor with a greater affinity for the serotonin transporter (SERT). (practicalanxietysolutions.com)
  • We investigated whether clomipramine , a tricyclic antidepressant drug with anti- trypanothione reductase and anti- calmodulin effects, could be effective in treating Albino Swiss mice infected with trypomastigotes of a new T. cruzi isolate from a chronic patient from an endemic area of Argentina in two different treatment schedules. (curehunter.com)
  • We measured the cortisol response to the 5-HT precursor, 5-hydroxytryptophan, (5-HTP) in seven patients with major depression before and after 8 weeks treatment with the tricyclic antidepressant, clomipramine. (ox.ac.uk)
  • In this regard, it was previously demonstrated that clomipramine, a widely used FDA-approved tricyclic antidepressant, interferes with the autophagic flux and severely compromises the viability of tumorigenic cells upon cytotoxic stress. (unical.it)
  • Clomipramine is a tricyclic antidepressant (TCA), prescribed for obsessive-compulsive disorder. (medindia.net)
  • Clomipramine is a member of the tricyclic antidepressant drug class (TCA). (practicalanxietysolutions.com)
  • Clomipramine is a tricyclic dibenzazepine antidepressant. (practicalanxietysolutions.com)
  • A tertiary amine known as clomipramine is a member of the tricyclic antidepressant. (practicalanxietysolutions.com)
  • Patients who get long-term treatment with the tricyclic antidepressant Clomipramine experience increased appetites and weight gain. (practicalanxietysolutions.com)
  • Clomipramine is a tricyclic antidepressant that is used to treat symptoms of obsessive-compulsive disorder (OCD), such as recurrent thoughts or feelings and repetitive actions. (alltabsonline.com)
  • Clomicalm (clomipramine) is a tricyclic antidepressant that affects chemicals in the brain (serotonin) that may become unbalanced leading to behavioral problems in dogs. (1800petmeds.com)
  • CLOMIPRAMINE is an antidepressant. (mydiscountpill.com)
  • After several weeks of treatment, clomipramine is usually taken once a day at bedtime. (medlineplus.gov)
  • The cortisol response to 5-HTP was significantly increased following clomipramine treatment, suggesting that clomipramine, like selective serotonin re-uptake inhibitors (SSRIs), enhances this 5-HT2 receptor mediated response. (ox.ac.uk)
  • However, facilitation of neurotransmission at 5-HT2 receptors could account for the efficacy of clomipramine and SSRIs in the treatment of obsessive compulsive disorder and also for their liability to cause orgasmic dysfunction. (ox.ac.uk)
  • SSRIs or clomipramine should be advanced as tolerated to a therapeutic dose. (medscape.com)
  • SSRIs are generally preferred over clomipramine in treating OCD. (medscape.com)
  • Drugs that increase serotonin signalling in the brain slow ejaculation and have been used successfully to treat PE These include selective serotonin reuptake inhibitors SSRIs such as paroxetine or dapoxetine, as well as clomipramine Ejaculatory delay typically begins within a week of beginning medication. (moph.go.th)
  • Acheter clomiphene online / achat clomid en france / pharmacie canada clomid sans ordonnance : Bien que acheter clomiphene online quelle réponse dans seroquel doses for anxiety . (sanlorenzoturismo.es)
  • The relationship between dose and clomipramine/desmethylclomipramine concentrations at higher daily doses has not been systematically assessed, but if there is significant dose dependency at doses above 150 mg/day, there is the potential for dramatically higher C ss and AUC even for patients dosed within the recommended range. (nih.gov)
  • Clomipramine/desmethylclomipramine. (geisingermedicallabs.com)
  • Clomipramine enhances the cortisol response to 5-HTP: implications for the therapeutic role of 5-HT2 receptors. (ox.ac.uk)
  • If you are taking clomipramine for depression, you may feel that it is not working for you straightaway. (alltabsonline.com)
  • The doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with clomipramine. (medlineplus.gov)
  • At the beginning of treatment, clomipramine is usually taken three times a day with meals as the body adjusts to the medication. (medlineplus.gov)
  • One clomipramine responder was subsequently followed in open maintenance treatment with clomipramine for 4 years, and her depersonalization symptoms remained in almost complete remission, with relapses upon each attempt to taper off or switch medication. (biopsychiatry.com)
  • Your doctor may start you on a low dose of clomipramine and gradually increase your dose. (medlineplus.gov)
  • To lessen side effects such as stomach upset, clomipramine may be started at a low dose, given in several doses during the day with meals, and slowly increased as your body gets used to it. (blinkhealth.com)
  • After a single 50 mg oral dose, maximum plasma concentrations of clomipramine occur within 2 to 6 hours (mean, 4.7 hr) and range from 56 ng/mL to 154 ng/mL (mean, 92 ng/mL). (nih.gov)
  • The effects of alcohol and clomipramine vary depending on the dose. (practicalanxietysolutions.com)
  • IMSEAR at SEARO: Experimental evaluation of the possible neuroleptic activity of clomipramine. (who.int)
  • Clomipramine was therefore tested for neuroleptic activity. (who.int)
  • The bioavailability of clomipramine from capsules is not significantly affected by food. (nih.gov)
  • Clomipramine can help ease the symptoms in each of these conditions. (alltabsonline.com)
  • Clomipramine is used to treat people with obsessive-compulsive disorder (a condition that causes repeated unwanted thoughts and the need to perform certain behaviors over and over). (medlineplus.gov)
  • Clomipramine is used to treat obsessive compulsive disorder (OCD). (blinkhealth.com)
  • Clomipramine is presumed to influence obsessive and compulsive behaviors through its effects on serotonergic neuronal transmission. (nih.gov)
  • FDA-approved Clomipramine for the treatment of obsessive-compulsive disorder (OCD) in people ten years of age and older. (practicalanxietysolutions.com)
  • Trypanosoma cruzi: chemotherapeutic effects of clomipramine in mice infected with an isolate obtained from an endemic area. (curehunter.com)
  • The aim of the present work was to evaluate the distribution of the different clones of the parasite prevailing after treatment with benznidazole (BZ) and clomipramine (CLO), in mice infected with Trypanosoma cruzi, Casibla isolate which consists of a mixture of two discrete typing units (DTUs). (bvsalud.org)
  • CONCLUSIONS: Clomipramine may be a promising pharmacologic treatment for primary depersonalization disorder and warrants further investigation. (biopsychiatry.com)
  • Clomipramine 75 mg is not a controlled substance under the Controlled Substances Act (CSA). (drugs.com)
  • Many people experience a feeling of vigor and strength at modest doses of alcohol and clomipramine. (practicalanxietysolutions.com)
  • Votre pharmacie en ligne, leverage your professional network, and .S seroquel doses for anxiety . (sanlorenzoturismo.es)
  • She was in a coma because she had taken an overdose of benzodiazepine and clomipramine in a suicide attempt. (cdc.gov)
  • Patients on clomipramine have experienced stomach trouble, dry mouth, and increased drowsiness and weariness, among other side effects. (practicalanxietysolutions.com)
  • Your healthcare provider will want to see you often while you are taking clomipramine, especially at the beginning of your treatment. (medlineplus.gov)