Clomiphene: A triphenyl ethylene stilbene derivative which is an estrogen agonist or antagonist depending on the target tissue. Note that ENCLOMIPHENE and ZUCLOMIPHENE are the (E) and (Z) isomers of Clomiphene respectively.Fertility Agents, Female: Compounds which increase the capacity to conceive in females.Ovulation Induction: Techniques for the artifical induction of ovulation, the rupture of the follicle and release of the ovum.Anovulation: Suspension or cessation of OVULATION in animals or humans with follicle-containing ovaries (OVARIAN FOLLICLE). Depending on the etiology, OVULATION may be induced with appropriate therapy.Infertility, Female: Diminished or absent ability of a female to achieve conception.Enclomiphene: The trans or (E)-isomer of clomiphene.Polycystic Ovary Syndrome: A complex disorder characterized by infertility, HIRSUTISM; OBESITY; and various menstrual disturbances such as OLIGOMENORRHEA; AMENORRHEA; ANOVULATION. Polycystic ovary syndrome is usually associated with bilateral enlarged ovaries studded with atretic follicles, not with cysts. The term, polycystic ovary, is misleading.Ethamoxytriphetol: A non-steroidal estrogen antagonist.Pregnancy Rate: The ratio of the number of conceptions (CONCEPTION) including LIVE BIRTH; STILLBIRTH; and fetal losses, to the mean number of females of reproductive age in a population during a set time period.Estrogen Antagonists: Compounds which inhibit or antagonize the action or biosynthesis of estrogenic compounds.Nafoxidine: An estrogen antagonist that has been used in the treatment of breast cancer.Ovulation: The discharge of an OVUM from a rupturing follicle in the OVARY.Electrocoagulation: Procedures using an electrically heated wire or scalpel to treat hemorrhage (e.g., bleeding ulcers) and to ablate tumors, mucosal lesions, and refractory arrhythmias. It is different from ELECTROSURGERY which is used more for cutting tissue than destroying and in which the patient is part of the electric circuit.Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)Live Birth: The event that a FETUS is born alive with heartbeats or RESPIRATION regardless of GESTATIONAL AGE. Such liveborn is called a newborn infant (INFANT, NEWBORN).Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.Insemination, Artificial: Artificial introduction of SEMEN or SPERMATOZOA into the VAGINA to facilitate FERTILIZATION.Ovarian Function Tests: Methods used for assessment of ovarian function.Gonadotropins: Hormones that stimulate gonadal functions such as GAMETOGENESIS and sex steroid hormone production in the OVARY and the TESTIS. Major gonadotropins are glycoproteins produced primarily by the adenohypophysis (GONADOTROPINS, PITUITARY) and the placenta (CHORIONIC GONADOTROPIN). In some species, pituitary PROLACTIN and PLACENTAL LACTOGEN exert some luteotropic activities.Follicle Stimulating Hormone: A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Follicle-stimulating hormone stimulates GAMETOGENESIS and the supporting cells such as the ovarian GRANULOSA CELLS, the testicular SERTOLI CELLS, and LEYDIG CELLS. FSH consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity.Insemination, Artificial, Homologous: Human artificial insemination in which the husband's semen is used.Gamete Intrafallopian Transfer: A technique that came into use in the mid-1980's for assisted conception in infertile women with normal fallopian tubes. The protocol consists of hormonal stimulation of the ovaries, followed by laparoscopic follicular aspiration of oocytes, and then the transfer of sperm and oocytes by catheterization into the fallopian tubes.Reproductive Techniques: Methods pertaining to the generation of new individuals, including techniques used in selective BREEDING, cloning (CLONING, ORGANISM), and assisted reproduction (REPRODUCTIVE TECHNIQUES, ASSISTED).Amenorrhea: Absence of menstruation.Superovulation: Occurrence or induction of release of more ova than are normally released at the same time in a given species. The term applies to both animals and humans.Infertility: Inability to reproduce after a specified period of unprotected intercourse. Reproductive sterility is permanent infertility.Ovary: The reproductive organ (GONADS) in female animals. In vertebrates, the ovary contains two functional parts: the OVARIAN FOLLICLE for the production of female germ cells (OOGENESIS); and the endocrine cells (GRANULOSA CELLS; THECA CELLS; and LUTEAL CELLS) for the production of ESTROGENS and PROGESTERONE.Estradiol: The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids.Luteinizing Hormone: A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Luteinizing hormone regulates steroid production by the interstitial cells of the TESTIS and the OVARY. The preovulatory LUTEINIZING HORMONE surge in females induces OVULATION, and subsequent LUTEINIZATION of the follicle. LUTEINIZING HORMONE consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH and FSH), but the beta subunit is unique and confers its biological specificity.Insemination: The deposit of SEMEN or SPERMATOZOA into the VAGINA to facilitate FERTILIZATION.Fertilization in Vitro: An assisted reproductive technique that includes the direct handling and manipulation of oocytes and sperm to achieve fertilization in vitro.Menstruation: The periodic shedding of the ENDOMETRIUM and associated menstrual bleeding in the MENSTRUAL CYCLE of humans and primates. Menstruation is due to the decline in circulating PROGESTERONE, and occurs at the late LUTEAL PHASE when LUTEOLYSIS of the CORPUS LUTEUM takes place.Buserelin: A potent synthetic analog of GONADOTROPIN-RELEASING HORMONE with D-serine substitution at residue 6, glycine10 deletion, and other modifications.Drug Resistance: Diminished or failed response of an organism, disease or tissue to the intended effectiveness of a chemical or drug. It should be differentiated from DRUG TOLERANCE which is the progressive diminution of the susceptibility of a human or animal to the effects of a drug, as a result of continued administration.Dydrogesterone: A synthetic progestational hormone with no androgenic or estrogenic properties. Unlike many other progestational compounds, dydrogesterone produces no increase in temperature and does not inhibit OVULATION.Birth Rate: The number of births in a given population per year or other unit of time.Ovarian Follicle: An OOCYTE-containing structure in the cortex of the OVARY. The oocyte is enclosed by a layer of GRANULOSA CELLS providing a nourishing microenvironment (FOLLICULAR FLUID). The number and size of follicles vary depending on the age and reproductive state of the female. The growing follicles are divided into five stages: primary, secondary, tertiary, Graafian, and atretic. Follicular growth and steroidogenesis depend on the presence of GONADOTROPINS.Oligomenorrhea: Abnormally infrequent menstruation.Pregnancy, Multiple: The condition of carrying two or more FETUSES simultaneously.Pregnancy Outcome: Results of conception and ensuing pregnancy, including LIVE BIRTH; STILLBIRTH; SPONTANEOUS ABORTION; INDUCED ABORTION. The outcome may follow natural or artificial insemination or any of the various ASSISTED REPRODUCTIVE TECHNIQUES, such as EMBRYO TRANSFER or FERTILIZATION IN VITRO.Pituitary Gland: A small, unpaired gland situated in the SELLA TURCICA. It is connected to the HYPOTHALAMUS by a short stalk which is called the INFUNDIBULUM.Congenital Abnormalities: Malformations of organs or body parts during development in utero.Gastroschisis: A congenital defect with major fissure in the ABDOMINAL WALL lateral to, but not at, the UMBILICUS. This results in the extrusion of VISCERA. Unlike OMPHALOCELE, herniated structures in gastroschisis are not covered by a sac or PERITONEUM.Abnormalities, Drug-Induced: Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.Privacy: The state of being free from intrusion or disturbance in one's private life or affairs. (Random House Unabridged Dictionary, 2d ed, 1993)Confidentiality: The privacy of information and its protection against unauthorized disclosure.Computer Security: Protective measures against unauthorized access to or interference with computer operating systems, telecommunications, or data structures, especially the modification, deletion, destruction, or release of data in computers. It includes methods of forestalling interference by computer viruses or so-called computer hackers aiming to compromise stored data.Obstetrics: A medical-surgical specialty concerned with management and care of women during pregnancy, parturition, and the puerperium.Gynecology: A medical-surgical specialty concerned with the physiology and disorders primarily of the female genital tract, as well as female endocrinology and reproductive physiology.PubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Hyperandrogenism: A condition caused by the excessive secretion of ANDROGENS from the ADRENAL CORTEX; the OVARIES; or the TESTES. The clinical significance in males is negligible. In women, the common manifestations are HIRSUTISM and VIRILISM as seen in patients with POLYCYSTIC OVARY SYNDROME and ADRENOCORTICAL HYPERFUNCTION.Books

Endometrial oestrogen and progesterone receptors and their relationship to sonographic appearance of the endometrium. (1/317)

The rapid development of ultrasonographic equipment now permits instantaneous assessment of follicles and endometrium. The sonographic appearance of the endometrium has been discussed in relation to in-vitro fertilization (IVF) cycles. However, a generally agreed view of the relationship of the sonographic appearance to fecundity in IVF cycles has not emerged. We have studied the relationship between steroid receptors and the sonographic appearance of the preovulatory endometrium in natural cycles and ovulation induction cycles. Preovulatory endometrial thickness was not found to be indicative of fecundity, although a preovulatory endometrial thickness of <9 mm related to an elevated miscarriage rate. The preovulatory endometrial echo pattern did not predict fecundity. No relationships were found among endometrial appearance, endometrial steroid receptors and steroid hormone concentrations in serum. Oestrogen or progesterone receptor concentrations were not related to endometrial thickness or to concentrations of serum oestradiol, the only significant correlation being found between the endometrial concentrations of oestrogen and progesterone receptors. The ratio of progesterone:oestrogen receptor concentration was somewhat less in echo pattern B (not triple line) endometrium compared with pattern A (triple line) endometrium. Oestrogen and progesterone receptor concentrations appeared stable on gonadotrophin induction, though fewer numbers were found during clomiphene cycles than in natural cycles. With regard to the distribution of receptor concentration between clomiphene and natural cycles, most women using clomiphene had very low oestrogen receptor populations. Pregnancy rates were low, in spite of high ovulatory rates during clomiphene treatment and were mainly related to low oestrogen receptor concentrations in preovulatory endometrium.  (+info)

Uterine peristalsis during the follicular phase of the menstrual cycle: effects of oestrogen, antioestrogen and oxytocin. (2/317)

Uterine peristalsis, directing sustained and rapid sperm transport from the external cervical os or the cervical crypts to the isthmic part of the tube ipsilateral to the dominant follicle, changes in direction and frequency during the menstrual cycle, with lowest activity during menstruation and highest activity at mid cycle. It was therefore suggested that uterine peristalsis is under the control of the dominant follicle with the additional involvement of oxytocin. To test this hypothesis, vaginal sonography of uterine peristalsis was performed in the early, mid and late proliferative phases, respectively, of cycles of women treated with oestradiol valerate and with human menopausal gonadotrophin following pituitary downregulation, with clomiphene citrate and with intravenous oxytocin, respectively. Administration of oestradiol valerate resulted in oestradiol serum concentrations comparable with the normal cycle with a simulation of the normal frequency of peristaltic contractions. Elevated oestradiol concentrations and bolus injections of oxytocin resulted in a significant increase in the frequency of peristaltic contractions in the early and mid follicular phases, respectively. Chlomiphene tended, though insignificantly so, to suppress the frequency of peristaltic waves in the presence of elevated oestradiol concentrations. In the late follicular phase of the cycle extremely elevated oestradiol concentrations as well as the injection of oxytocin resulted only in an insignificant further increase of peristaltic frequency. In the normal cycles, as well as during extremely elevated oestradiol concentrations and following oxytocin administration, the peristaltic contractions were always confined to the subendometrial layer of the muscular wall. The results and the review of literature indicate that uterine peristalsis during the follicular phase of the menstrual cycle is controlled by oestradiol released from the dominant follicle with the probable involvement of oxytocin, which is presumably stimulated together with its receptor within the endometrial-subendometrial unit and therefore acting in an autocrine/paracrine fashion. Since unphysiological stimulation with oestradiol and oxytocin did not significantly increase the frequency of uterine peristalsis in the late follicular phase of the cycle it is assumed that normal preovulatory frequency of uterine peristalsis is at a level which cannot be significantly surpassed due to phenomena of refractoriness of the system.  (+info)

Endometrial evaluation is not predictive for in vitro fertilization treatment. (3/317)

PURPOSE: The main purpose of this study was to evaluate ovarian function by clomiphene citrate (CC) challenge test in a group of tubal infertile women and to study endometrial morphological maturation in the early luteal phase of CC-stimulated cycles as compared to in vitro fertilization (IVF) treatment outcome. METHODS AND RESULTS: Four women presented with strongly retarded, proliferative endometrium in the luteal phase. Of these, three presented with impaired ovarian function, high basal follicle-stimulating hormone, and high follicle-stimulating hormone levels after clomiphene stimulation on cycle day 10. In the remaining 30 women, showing an in-phase endometrium after CC stimulation, a comparison of six morphological characteristics did not reveal any significant differences between the 14 women who did become pregnant and the 16 who did not. No significant differences in endometrial thickness were observed between the groups. Significant differences were found when comparing estradiol and progesterone area under the curve during the luteal phase (P < 0.001 and P < 0.01, respectively) between those who did and those who did not become pregnant. CONCLUSIONS: Luteal endometrium morphology was not a sharp instrument to detect differences between women who did and women who did not become pregnant following IVF treatment, while ovarian function, as measured by hormonal markers, seemed to be a more reliable prognostic factor for IVF treatment outcome.  (+info)

Effects of clomiphene citrate and progesterone on resting and proliferative cell-populations in resting and proliferative cell-populations in mouse uterine epithelium. (4/317)

Resting cells (GO cells) of the uterine surface epithelium in castrated mice began to synthesize DNA with high synchrony from 10 hr after the injection of 50 ng of estradiol-17beta with or without 5.5 mug of clomiphene citrate. Highly synchronized DNA synthesis in GO cells elicited with estradiol was delayed approximately 5 hr when the simultaneous administration of 0.5 mg of progesterone was given. In GO cells of castrated mice which received 5.5 mug of clomiphene or 55 mug of clomiphene plus 50 ng of estradiol, DNA synthesis with partial synchrony began 15 hr after the injection. The effects of estradiol were completely suppressed by the administration of 55 mug of clomiphene. It is suggested that the inhibitory action of clomiphene may be due to the competitive blocking of estrogen binding, while progesterone suppresses the estrogen-induced DNA synthesis of the surface epithelium and transfers them to the GO cell-compartment.  (+info)

Intrauterine insemination treatment in subfertility: an analysis of factors affecting outcome. (5/317)

A total of 811 intrauterine insemination (IUI) cycles in which clomiphene citrate/human menopausal gonadotrophin (HMG) was used for ovarian stimulation were analysed retrospectively to identify prognostic factors regarding treatment outcome. The overall pregnancy rate was 12.6% per cycle, the multiple pregnancy rate 13.7%, and the miscarriage rate 23.5%. Logistic regression analysis revealed five predictive variables as regards pregnancy: number of the treatment cycle (P = 0.009), duration of infertility (P = 0.017), age (P = 0.028), number of follicles (P = 0.031) and infertility aetiology (P = 0.045). The odds ratios for age < 40 years, unexplained infertility aetiology (versus endometriosis) and duration of infertility < or = 6 years were 3.24, 2.79 and 2.33, respectively. A multifollicular ovarian response to clomiphene citrate/HMG resulted in better treatment success than a monofollicular response, and 97% of the pregnancies were obtained in the first four treatment cycles. The results indicate that clomiphene citrate/HMG/IUI is a useful and cost-effective treatment option in women < 40 years of age with infertility duration < or = 6 years, who do not suffer from endometriosis.  (+info)

Anovulations in an ovary during two menstrual cycles enhance the pregnancy potential of oocytes matured in that ovary during the following third cycle. (6/317)

The aim of this study was to test whether ovulation from an ovary affects the health of oocytes from dominant follicles in that ovary two cycles later. A total of 80 women each with two intact ovaries underwent 270 treatment cycles (155 natural cycles and 115 clomiphene citrate cycles) all showing unilateral ovulation. The results from the in-vitro fertilization (IVF) treatment were grouped according to whether ovulation (O) or anovulation (A) (no ovulation) was observed in the ovary with dominant follicle during the treatment cycle in the previous two cycles: O-O, A-O, O-A and A-A (previous second cycle-previous first cycle). The rate of pre-embryo formation in A-A was significantly higher than that of O-A. The pregnancy rate in A-A (29%) was also higher than those of O-A (13%), A-O (9%) and O-O (5%). These rates increased from O-O to A-A as the number of previous ovulations in an ovary decreased. The presence of a corpus luteum and/or a dominant follicle is likely to exert local negative effects on the health of the oocyte contained in the follicle selected to ovulate up to two cycles later. Anovulations in an ovary for two menstrual cycles may therefore provide improved conditions for the development of a healthier oocyte with an increased pregnancy potential.  (+info)

The effect of smoking on oocyte quality and hormonal parameters of patients undergoing in vitro fertilization-embryo transfer. (7/317)

PURPOSE: The aim of the present study was to investigate the influence of smoking on different parameters such as oocyte count, embryo score, and basal hormone values within the scope of in vitro fertilization-embryo transfer (IVF-ET). METHODS: Eight hundred thirty-four women undergoing IVF-ET treatment were classified as smokers or nonsmokers on the basis of questionnaires. Additionally, we divided them into three groups according to their stimulation protocol--"combined stimulation" [I; clomiphene citrate plus human menopausal gonadotropin (hMG)], "ultrashort" [II; gonadotropin releasing hormone agonist (GnRHa) plus hMG or follicle-stimulating hormone (FSH)], and "long downregulation protocol" (III)--and further classified again as smokers or nonsmokers within the groups. RESULTS: In general, smoking patients were significantly (P = 0.0195) younger than nonsmokers and showed a significantly (P = 0.0379) lower embryo score and a tendency (P = 0.0931) to produce fewer oocytes. There was no significant difference concerning the number of normally or pathologically fertilized and transferred oocytes and embryos suitable for cryopreservation. Women who smoked had significantly (P = 0.0112) higher basal 17-beta-estradiol (E2), luteinizing hormone (LH) (P = 0.0001), and dehydroepian-drosteronesulfate (DHEAS) (P = 0.0039) levels, but their basal human prolactin (HPRL) levels were significantly (P = 0.0033) lower than those of nonsmokers. According to the stimulation protocol used, we found the following results. Smoking patients in group I showed a significantly (P = 0.023) lower embryo score and produced fewer oocytes (P = 0.0113), with fewer of them being fertilized (P = 0.0072) and transferred (P = 0.0067). Women who smoked had significantly (P = 0.0002) higher basal LH levels, but their HPRL levels were significantly (P = 0.031) lower than those of nonsmokers. Furthermore, they had a thinner endometrium on the day of embryo transfer (P = 0.0366). In group II we measured significantly elevated basal E2 levels (P = 0.0089) and higher LH values (P = 0.0092) in smokers. Group III showed a trend (P = 0.0565) toward lower HPRL values in smokers. CONCLUSIONS: Although the fertilization rate of oocytes and the pregnancy rate were not significantly different between smokers and nonsmokers, we found significantly alterated hormonal parameters and negatively influenced oocyte parameters, particularly after clomiphene stimulation. So we might consider using only GnRHa protocols for smoking patients. Additionally, we advise our patients to stop smoking before an IVF-ET treatment because of the complex effects of smoking on the reproductive and hormonal system.  (+info)

Hormone and fertility drug use and the risk of neuroblastoma: a report from the Children's Cancer Group and the Pediatric Oncology Group. (8/317)

Previous epidemiologic studies have suggested an association between maternal sex hormone use during pregnancy, including infertility medication, and an increased risk of neuroblastoma in the offspring. The authors conducted a case-control interview study from 1992 to 1996 that included 504 children less than 19 years of age whose newly diagnosed neuroblastoma was identified by two national collaborative clinical trials groups in the United States and Canada, the Children's Cancer Group and the Pediatric Oncology Group. Controls, matched to cases on age, were identified by random digit dialing. No association was found for use of oral contraceptives before or during pregnancy (first trimester odds ratio (OR) = 1.0, 95% confidence interval (CI): 0.5, 2.1). The odds ratio was slightly elevated for history of infertility (OR = 1.4, 95% CI: 0.9, 2.1) and ever use of any infertility medication (OR = 1.2, 95% CI: 0.7, 2.2). Specifically, ever use of clomiphene was associated with a 1.6-fold increased risk (95% CI: 0.8, 3.0) but not periconceptionally or during the index pregnancy. A suggestive pattern was found for gender of the offspring, with an increased risk for males but not for females after exposure to oral contraceptives or clomiphene. This study did not find consistent and large increased risks for maternal use of hormones, but the suggestion of an association for male offspring requires further consideration.  (+info)

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To schedule an appointment or for more information about this practice as well as the programs and treatments they offer, please complete the form below. ClomiPHENE citrate therapy cannot be expected to substitute for specific medical conditions. Funny, at age 31 and dreadfully having semipermanent any type of infertility. Unprescribed Clomiphene Many healthy, fertile women have problems with ovulation. Gyno should not have any clue what Ive undeterred or congressional through. Text] Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning CLOMIPHENE may not be used. Page 252 Appears in 53 books from 1987-2008 The effects of clomiphene . Tim Fogarty wrote in message . This means that CLOMIPHENE is the "fertility pill". ClomiPHENE CLOMIPHENE has been reported to be in! I have nonmetallic a lot. Seek emergency medical attention. New onset of alopecia in a closed container at room temperature, away from light, moisture, and direct light. ...
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Clomiphene Citrate is the most used and abused medication for infertility treatment. It was introduced to the clinical market in 1967 and almost immediately replaced the surgical procedure - wedge resection of the ovaries - for primary treatment of anovulation in patients with polycystic ovarian disease (PCOD). Clomiphene Citrate is still widely used by gynecologists for that purpose and others. It is important to remember that proper use of the medication will usually yield gratifying results while expanding its use to lesser indications may be counterproductive and often results in unsuccessful outcomes. Clomiphene Citrates best and most common indication is for induction of ovulation in euestrogenic, normoprolactinemic, and anovulatory patients. The majority of these patients will have PCOD, which is a clinical diagnosis of chronic anovulation with symptoms and signs of Hyperandrogenism. The definition implies that there is adequate endogenous estrogen production and that hyperprolactinemia ...
BJU Int. 2012 Mar 28. doi: 10.1111/j.1464-410X.2012.10968.x. [Epub ahead of print] Clomiphene citrate is safe and effective for long-term management of hypogonadism.. Moskovic DJ, Katz DJ, Akhavan A, Park K, Mulhall JP.. Source: Sexual & Reproductive Medicine Program, Urology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.. Abstract. Study Type - Therapy (population cohort) Level of Evidence 2a Whats known on the subject? and What does the study add? Clomiphene citrate(CC) has previously been documented to be efficacious in the treatment of hypogonadism. However little is known about the long term efficacy and safety of CC. Our study demonstrates that CC is efficacious after 3 years of therapy. Testosterone levels and bone mineral density measurement improved significantly and were sustained over this prolonged period. Subjective improvements were also demonstrated. No adverse events were reported.. OBJECTIVE: To assess the efficacy and safety of long-term clomiphene citrate ...
This study used data from the National Birth Defects Prevention Study, a population-based, case-control study of major birth defects in the United States. Population-based means that the study looked at all babies with birth defects whose mothers live in the study region, which is important to make sure that study results apply to the U.S. population in general. Researchers wanted to see if there was a link between using clomiphene citrate and the occurrence of certain birth defects. Women who became pregnant by using assisted reproductive technologies, including in-vitro fertilization or IVF, were not included in this study.. A summary of the findings can be found below. The findings should be interpreted with caution because they are based on small numbers of women who used clomiphene citrate. Also, it is difficult to determine whether the findings are due to the use of the clomiphene citrate or because these women had difficulty getting pregnant due to some underlying conditions that affected ...
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Clomiphene citrate, a selective estrogen receptor modulator, increases estradiol levels and consequently may increase risk of cancer of the uterine corpus. The authors conducted a retrospective cohort study of 8,431 US women (145,876 woman-years) evaluated for infertility during 1965-1988. Through 1999, 39 uterine cancers were ascertained by questionnaire or cancer and death registries. Poisson regression estimated adjusted rate ratios. Study results suggest that clomiphene may increase uterine cancer risk (rate ratio (RR) = 1.79, 95% confidence interval (CI): 0.9, 3.4) and present evidence of a dose response (ptrend = 0.07) and latency effect (ptrend = 0.04). Uterine cancer risk increased with clomiphene dose (RR = 1.93, 95% CI: 0.9, 4.0 for ,900 mg), menstrual cycles of use (RR = 2.16, 95% CI: 0.9, 5.2 for ≥6 cycles), and time elapsed since initial use (RR = 2.50, 95% CI: 0.9, 7.2 for women followed for ≥20 years). Risk was more strongly associated with clomiphene among nulligravid (RR = ...
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To test whether adding small doses of HP urinary FSH to standard regimen of clomiphene citrate in clomiphene resistant PCOS well yield better results in terms of better ovulation rate,lower follicle number, less consumption of HP urinary FSH,lower treatment cost , better pregnancy rate, lower multiple pregnancy rates compared with the exclusive use of HP urinary FSH in these cases ...
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METHODS: A total of 60 women with PCOS and infertility were evaluated. Inclusions criteria were: age 26-34 years, nulliparity, above 3 years of sterility, multiple ovarian microcysts, BMI>27.5, oligomenorrhea/amenorrhea, hyperandrogenism and normal male fertility. Four patients were excluded (renal damage 2, tubal occlusion 1 and Pelvic Inflammatory Disease 1). The remaining 56 were divided into 2 groups: group A were inducted with Clomiphene Citrate alone, while group B were inducted with Clomiphene citrate and Metformin ...
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BACKGROUND: Recent studies suggest that metformin may be more effective in women with polycystic ovary syndrome (PCOS) who are non-obese. The objective here is to determine and compare the effectiveness of metformin and clomiphene citrate for improving fertility outcomes in women with PCOS and a BMI, 32 kg/m2 (BMI 32 kg/m2 was used to allow for international differences in BMI values which determine access to infertility therapy through the public health system). METHODS: Databases were searched for English language articles until July 2011. Inclusion criteria: women of any age, ethnicity and weight with PCOS diagnosed by all current criteria, who are infertile; at least 1000 mg of any type of metformin at any frequency, including slow release and standard release, compared with any type, dose and frequency of clomiphene citrate. Outcomes: rates of ovulation, live birth, pregnancy, multiple pregnancies, miscarriage, adverse events, quality of life and cost effectiveness. Data were extracted and ...
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OBJECTIVE: To compare the effectiveness of letrozole and clomiphene citrate (CC) in patients with anovulatory infertility. DESIGN: Open, prospective, randomized, parallel group, multicentric, comparative trial. SETTING: Out patient clinics of infertility centers in India. PATIENT(S): Fifty-five patients with anovulatory infertility were recruited. Twenty-seven patients (59 cycles) were given letrozole and twenty-eight patients (68 cycles) were given CC. Both drugs were given orally on days 3-7 of menstrual cycle. INTERVENTION(S): Letrozole, CC, ovulation induction, vaginal micronized progesterone, IUI ...
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The second phase of the HPTA protocol, clomiphene and tamoxifen, examines the ability of the hypothalamic-pituitary axis to respond to stimulation by producing LH levels within the normal reference range. The clomiphene citrate challenge differentiates secondary hypogonadism. Clomiphene is an antiestrogen, which decreases the estrogen effect in the body. It has a dual effect by stimulating the hypothalamic pituitary area and it has an antiestrogenic effect, so that it decreases the effect of estrogen in the body. Tamoxifen is more of a strict antiestrogen; it decreases the effect of estrogen in the body, and potentiates the action of clomiphene. Tamoxifen and clomiphene citrate compete with estrogen for estrogen receptor bind-ing sites, thus eliminating excess estrogen circulation at the level of the hypothalamus and pituitary, allowing gonadotropin production to resume. Administering them together produces an elevation of LH and secondar-ily gonadal sex hormones. The administration of ...
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Clomid (clomiphene citrate) Clomid is a SERM (selective estrogen receptor modulator) similar to Tamoxifen. It is typically used to induce ovulation in females by blocking estrogen in selective tissue in the body. Clomid opposes the negative feedback of estrogens on the Hypothalamic Pituitary Ovarian Axis which enhances the release of LH and FSH. Some women report a reduction in female pattern fat deposits when employing a SERM during an anabolic androgenic steroid cycle but typically
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Clomiphene (Clomifene) is used for the treatment of female infertility caused due to oligoovulation or anovulation. Clomiphene is selective estrogen receptor modulator, which increments the production of the gonadotropin necessary for female fertility.
Clomiphene is a nonsteroidal fertility medicine. It causes the pituitary gland to release hormones needed to stimulate ovulation (the release of an egg from the ovary). Clomiphene is used to cause ovulation in women with certain medical conditions (such as polycystic ovary syndrome) that prevent naturally occurring...
Current recommended 1st line treatment for ovulation induction remains the usage of clomiphene and patients should be informed that there is an increased risk of multiple pregnancies with ovulation induction using clomiphene. (Grade A, Level 1+ evidence). Recommended 2nd line intervention for subfertility in women with PCOS is either exogenous gonadotrophins or laparoscopic ovarian surgery. (Grade D, Level 4 evidence) Recommended 3rd line intervention for subfertility in women with PCOS is in vitro fertilization (IVF). (Grade C, Level 2+ evidence) The routine use of metformin in ovulation induction is not recommended as monotherapy or in combination with clomiphene. (Grade D, Level 3). On the other hand, the combined use of metformin and clomiphene is recommended for women with clomiphene resistance especially if they are obese (BMI , 27.5). (Grade A, Level 1+) In women who have been diagnosed with PCOS prior to pregnancy, especially those requiring ovulation inductions for conception, they ...
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Information on clomiphene, which is sold under the brand names Clomid, Serophene, and Milophene. It is a prescription drug typically used to treat infertility by inducing ovulation in women. Clomiphene may also be prescribed to treat infertility in men, if a pituitary imbalance hinders production of testosterone.
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Clomifene or Clomiphene or Clomid or Clomifert is a selective estrogen receptor modulator (SERM), used mainly in female infertility due to anovulation (e.g. due to polycystic ovary syndrome).
THURSDAY, April 23 (HealthDay News) -- Treatment consisting of gradually increasing doses of clomiphene followed by ultrasound is effective in reducing the time to ovulation and often improves the ovulation rate in women with polycystic ovarian syndrome (PCOS) who do not respond to lower doses of the drug, according to a study in the May issue of the American Journal of Obstetrics & Gynecology.. Bradley S. Hurst, M.D., and colleagues from Carolinas Medical Center in Charlotte, N. C., retrospectively analyzed whether a "stair-step" clomiphene protocol was effective in women with PCOS who did not respond to 50 milligrams clomiphene. The protocol consisted of increases in clomiphene dose from 50 mg to 100 mg and 150 mg if the woman remained unresponsive, with each increase in dose followed by ultrasonography.. The researchers found that the stair-step protocol reduced the time to ovulation by 32 to 53 days compared with traditional clomiphene dosing. The ovulation rate was significantly higher for ...
Clomiphene is generally tolerated well. Common side effects include mood swings, breast tenderness and nausea. Hot flashes occur in about 10% of women taking CC, and typically disappear soon after treatment ends. Occasionally, CC also may cause ovarian or pelvic discomfort.
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Testicular function declines with normal aging, while serum immunoreactive LH and FSH levels increase. Since there are reports of an age-related decrease in the ratio of bioactivity to immunoreactivity (B/I ratio) for LH, we used a newly available bioassay for FSH to assess age-associated changes in the bioactivity and B/I ratio of FSH in man. Thirty-nine healthy men (23 young and 16 elderly) had single blood samples drawn. In addition, a subset of these men (12 young and 13 elderly) underwent frequent blood sampling for 24 h, both before and after 7 days of clomiphene citrate (CC) administration. Hourly blood samples from the 24-h sampling were pooled, and these, along with the single samples, were assayed for FSH by an in vitro bioassay system, using estrogen production by immature rat granulosa cells as the end point, and by RIA. Baseline single sample mean FSH, as measured by bioassay, was similar in young and elderly men [386 +/- 98 (+/- SEM) and 342 +/- 77 ng/mL, respectively]. Baseline ...
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J Sex Med. 2010 Jan;7(1 Pt 1):269-76. Epub 2009 Aug 17.. Clomiphene citrate and testosterone gel replacement therapy for male hypogonadism: efficacyandtreatment cost.. Taylor F, Levine L.. Source: Rush University Medical Center-Department of Urology, Chicago, IL, USA. [email protected] Abstract. INTRODUCTION: The efficacy of oral clomiphene citrate (CC) in the treatment of male hypogonadismand male infertility (MI) with low serumtestosterone and normal gonadotropin levels has been reported.. AIM: The aim of this article is to evaluate CC and testosterone gel replacement therapy (TGRT) with regard to biochemical and clinical efficacy andcost.. MAIN OUTCOME MEASURES: The main outcome measures were change in serum testosterone with CC and TGRT therapy, and change in the androgen deficiency in aging male (ADAM) questionnaire scores with CC therapy.. METHODS: Men receiving CC or TGRT with either Androgel 1% or Testim 1% for hypogonadism(defined as testosterone , 300 ng/mL) or MI were ...
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BACKGROUND Although FIVET and ICSI efficacy and efficiency are continuously increasing, intrauterine insemination (IUI) is a very used technique for many different types of sterility. It is also used in male sterility for its cost/benefit positive rate. Pregnancies frequency obtained after IUI in male factor infertility cases, with or without ovarian stimulation, shows the value of this work. METHODS We evaluated 149 insemination cycles in 34 couples with a male infertility diagnosis confirmed after at least 2 semen analysis, according to OMS criteria. All the 34 patients had at least one Fallopian tube open and some spontaneous ovulatory cycle to enter in this study. The patients without biochemical pregnancy signs after 6 intrauterine insemination cycles were induced to multiple ovulations through oral administration of 50 mg of Clomifene citrate from the 5th to the 9th cycle-day or through intramuscular administration of 75 I.U. of FSH from the 5th cycle-day. A luteal support with 200 mg of vaginal
DrugBank > Clomifene. Updated on April 19, 2011 Kousta E, White DM, Franks S (1997). "Modern use of clomiphene citrate in ... The main treatments are clomifene citrate and gonadotropins. Clomifene citrate (or clomid) is the medication which is most ... comparing clomiphene with metformin, clomiphene was more effective than metformin alone. Following this study, the ESHRE/ASRM- ... Clomifene citrate is a very efficient ovulation inductor, and has a success rate of 67%. Nevertheless, it only has a 37% ...
The drug clomiphene, a drug commonly used for ovulation stimulation in fertility treatments, has also been seen to be ... Bhambhani Vikas; George Sanila (2004). "Association of Clomiphene with Iniencephaly". Indian Pediatrics. 41: 517. Rasmussen, S ...
Use of clomiphene citrate in women. Fertil Steril 2003; 80:1302. Wallace WHB and Kelsey TW (2004)Ovarian reserve and ... This combination is sometimes referred to as the Biological Body Clock Test.[citation needed] A clomiphene challenge test is a ...
Greenblatt, R., Mahesh, V., & Jungck, E., Roy S. (1963). Clomiphene Citrate: Further Observations on Its Use in Induction of ... His group's discovery in 1961 that clomiphene citrate could induce ovulation was a breakthrough in reproductive biology, and ... Greenblatt, R., & Mahesh, V. (1965). Induction of Ovulation with Clomiphene Citrate. In T. Schwartz, Yearbook of Endocrinology ... clomiphene citrate is today the first choice in treating ovulatory disorders. He also showed that the drug Danazol was useful ...
Purvin, VA (Apr 1995). "Visual disturbance secondary to clomiphene citrate". Archives of ophthalmology. 113 (4): 482-4. doi: ... Trazodone, nefazodone, mirtazepine, topiramate, clomiphene, oral contraceptives, and risperidone have been reported to cause ...
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Clomifene seems to be less effective than tamoxifen or raloxifene. Tamoxifen may be used for painful gynecomastia in adults. ... Selective estrogen receptor modulators (SERMs) such as tamoxifen, raloxifene, and clomifene may be beneficial in the treatment ...
Jain JK, Kuo J (September 2004). "Pregnancy outcomes with increased clomiphene citrate dose". Gynecological Endocrinology. 19 ( ...
Vandekerckhove P, Lilford R, Vail A, Hughes E (2000). "Clomiphene or tamoxifen for idiopathic oligo/asthenospermia". Cochrane ... clomifene, fulvestrant, and aromatase inhibitors like anastrozole, and, only in men, pure antiandrogens such as flutamide, ...
Kovacs, P (2004). "HCG injection after ovulation induction with clomiphene citrate". Medscape. Retrieved 2011-08-01. Oyawoye OA ...
2015). "Letrozole, Gonadotropin, or Clomiphene for Unexplained Infertility". N Engl J Med. 373 (13): 1230-1240. doi:10.1056/ ... as compared with gonadotropin but not with clomiphene. Side effects include an increased risk for developing osteoporosis and ...
Clomifene is a mixture of estrogenic (cis-form) and antiestrogenic isomers (trans-form). Cis and trans are defined in terms of ... SERMs like clomifene and tamoxifen are more in the middle in their IA and their balance of estrogenic and antiestrogenic ... Clomifene successfully induced ovulation in subfertile women and on February 1, 1967, it was approved in the US for the ... Clomifene and torimefene produce binding affinities similar to that of tamoxifen. Thus, these two drugs are more selective ...
Clomiphene citrate has been used with modest success. The combination of tamoxifen plus testosterone was reported to improve ... Empirically many medical approaches have been tried including clomiphene citrate, tamoxifen, HMG, FSH, HCG, testosterone, ...
A team at William S. Merrell Chemical Company led by Frank Palopoli synthesized clomifene in 1956; after its biological ... pharmacology and clinical experience with clomiphene citrate" (PDF). Human Reproduction Update. 2 (6): 483-506. doi:10.1093/ ...
For subfertility, treatment may include clomiphene citrate or gonadotropins. Hypothalamic-pituitary-prolactin axis ...
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... but it appears less effective than clomiphene. For women not responsive to clomiphene and diet and lifestyle modification, ... Efforts to improve fertility include weight loss, clomiphene, or metformin. In vitro fertilization is used by some in whom ... Metformin improves the efficacy of fertility treatment when used in combination with clomiphene. Metformin is thought to be ... 27 June 2017). "Effect of Acupuncture and Clomiphene in Chinese Women With Polycystic Ovary Syndrome: A Randomized Clinical ...
Examples of anti-estrogens are: anastrozole, clomiphene, tamoxifen, and formestane. Anastrozole, brand name Arimidex, is a type ...
Clomiphene Citrate, Clomid Archived 2014-05-10 at Archive.is. By Robert B. McWilliams. The Center for Reproduction and Women's ... In cycles stimulated with clomifene for intended conception by sexual intercourse, however, triggering oocyte release has been ... HCG Injection After Ovulation Induction With Clomiphene Citrate at Medscape. By Peter Kovacs. Posted: 04/23/2004 Farquhar, ... "Use of clomiphene citrate in infertile women: a committee opinion". Fertil. Steril. 100 (2): 341-8. doi:10.1016/j.fertnstert. ...
As such, clomiphene citrate (an antiestrogen) and aromatase inhibitors such as testolactone or anastrozole have shown ... Ghanem H, Shaeer O, El-Segini A (2010). "Combination clomiphene citrate and antioxidant therapy for idiopathic male infertility ... Although controversial, off-label clomiphene citrate, an antiestrogen, may also be effective by elevating gonadotropin levels. ... ISBN 978-1-60761-193-6. Pasqualotto FF, Fonseca GP, Pasqualotto EB (2008). "Azoospermia after treatment with clomiphene citrate ...
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"Use of clomiphene to increase bone mass in premenopausal women '13 Nov 1990'". Justia Patents. Retrieved 11 June 2015. Hutkin, ... using clomifene.Andrews, Edmund (29 April 1989). "Patents; A Method to Determine Fertility in Women". New York Times. Retrieved ... Comite was awarded a second patent for the use of clomifene to increase bone mass in premenopausal women. Dr. Comite is known ...
... (INN), also known as clomifene N-oxide, is a nonsteroidal selective estrogen receptor modulator (SERM) of the ... It is an active metabolite of clomifene. Afimoxifene Endoxifen J. Elks (14 November 2014). The Dictionary of Drugs: Chemical ...
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... and a metformin-clomifene combination no better than clomifene alone. Reflecting this, subsequent reviews large randomized ... "Effect of clomifene citrate plus metformin and clomifene citrate plus placebo on induction of ovulation in women with newly ... February 2007). "Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome". N Engl J Med. 356 (6): 551- ... The guidelines suggest clomiphene as the first medication option and emphasize lifestyle modification independently from ...
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  • CLOMID (clomiphene will avoid the athlete stops transformered into estrogen. (wcradio.com)
  • Clomiphene citrate (CC) and related triarylethylene antiestrogens to antagonize the growth promoting effect of estrogens in target tissues have focused attention on the potential application of these compounds in estrogen receptor positive breast cancer treatment and prevention [ 9 ]. (hindawi.com)
  • Clomiphene citrate is a triphenylethylene compound, belonging to a family of synthetic nonsteroidal estrogens/antiestrogens and selective estrogen receptor modulators (SERMs). (hindawi.com)
  • Clomiphene works by inhibiting the function of the estrogen receptors present in the hypothalamus region of the brain. (theimagearchitect.com)
  • Therefore, Clomiphene directly inhibits the negative feedback mechanism on the production of gonadotropin done by the estrogen. (theimagearchitect.com)
  • MER-25 and clomiphene citrate are drugs that affect estrogen production in women. (asu.edu)
  • Being both estrogen blockers, is considering slightly Clomid than Nolvadex.Clomiphene citrate is characterized with both agonist / antagonist properties. (steroid-planet.com)
  • Experts used to think miscarriage rates were slightly higher in women who became pregnant using clomiphene. (emedicinehealth.com)
  • In some studies, miscarriage rates are slightly higher in women who become pregnant using clomiphene. (emedicinehealth.com)