Clofazimine: A fat-soluble riminophenazine dye used for the treatment of leprosy. It has been used investigationally in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in AIDS patients. Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum. (From AMA Drug Evaluations Annual, 1993, p1619)Leprostatic Agents: Substances that suppress Mycobacterium leprae, ameliorate the clinical manifestations of leprosy, and/or reduce the incidence and severity of leprous reactions.Dapsone: A sulfone active against a wide range of bacteria but mainly employed for its actions against MYCOBACTERIUM LEPRAE. Its mechanism of action is probably similar to that of the SULFONAMIDES which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with PYRIMETHAMINE in the treatment of malaria. (From Martindale, The Extra Pharmacopoeia, 30th ed, p157-8)Leprosy, Multibacillary: A form of LEPROSY classified by the World Health Organization for the purpose of treatment, based on clinical manifestations and skin smear results. Patients with multibacillary leprosy have six or more lesions with or without positive skin smear results for the causative agent MYCOBACTERIUM LEPRAE. Multibacillary leprosy encompasses borderline lepromatous, midborderline, and lepromatous leprosy.Mycobacterium avium-intracellulare Infection: A nontuberculous infection when occurring in humans. It is characterized by pulmonary disease, lymphadenitis in children, and systemic disease in AIDS patients. Mycobacterium avium-intracellulare infection of birds and swine results in tuberculosis.Mycobacterium avium Complex: A complex that includes several strains of M. avium. M. intracellulare is not easily distinguished from M. avium and therefore is included in the complex. These organisms are most frequently found in pulmonary secretions from persons with a tuberculous-like mycobacteriosis. Strains of this complex have also been associated with childhood lymphadenitis and AIDS; M. avium alone causes tuberculosis in a variety of birds and other animals, including pigs.Leprosy: A chronic granulomatous infection caused by MYCOBACTERIUM LEPRAE. The granulomatous lesions are manifested in the skin, the mucous membranes, and the peripheral nerves. Two polar or principal types are lepromatous and tuberculoid.PhenazinesEthambutol: An antitubercular agent that inhibits the transfer of mycolic acids into the cell wall of the tubercle bacillus. It may also inhibit the synthesis of spermidine in mycobacteria. The action is usually bactericidal, and the drug can penetrate human cell membranes to exert its lethal effect. (From Smith and Reynard, Textbook of Pharmacology, 1992, p863)Rifabutin: A broad-spectrum antibiotic that is being used as prophylaxis against disseminated Mycobacterium avium complex infection in HIV-positive patients.Rifampin: A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)Pigmentation DisordersAmikacin: A broad-spectrum antibiotic derived from KANAMYCIN. It is reno- and oto-toxic like the other aminoglycoside antibiotics.Antitubercular Agents: Drugs used in the treatment of tuberculosis. They are divided into two main classes: "first-line" agents, those with the greatest efficacy and acceptable degrees of toxicity used successfully in the great majority of cases; and "second-line" drugs used in drug-resistant cases or those in which some other patient-related condition has compromised the effectiveness of primary therapy.Roxithromycin: Semisynthetic derivative of erythromycin. It is concentrated by human phagocytes and is bioactive intracellularly. While the drug is active against a wide spectrum of pathogens, it is particularly effective in the treatment of respiratory and genital tract infections.Erythema Nodosum: An erythematous eruption commonly associated with drug reactions or infection and characterized by inflammatory nodules that are usually tender, multiple, and bilateral. These nodules are located predominantly on the shins with less common occurrence on the thighs and forearms. They undergo characteristic color changes ending in temporary bruise-like areas. This condition usually subsides in 3-6 weeks without scarring or atrophy.Liquid Crystals: Materials in intermediate state between solid and liquid.Leprosy, Lepromatous: A chronic communicable infection which is a principal or polar form of LEPROSY. This disorder is caused by MYCOBACTERIUM LEPRAE and produces diffuse granulomatous skin lesions in the form of nodules, macules, or papules. The peripheral nerves are involved symmetrically and neural sequelae occur in the advanced stage.Product Labeling: Use of written, printed, or graphic materials upon or accompanying a product or its container or wrapper. It includes purpose, effect, description, directions, hazards, warnings, and other relevant information.Drug Interactions: The action of a drug that may affect the activity, metabolism, or toxicity of another drug.Tropical Medicine: The branch of medicine concerned with diseases, mainly of parasitic origin, common in tropical and subtropical regions.Mycobacterium leprae: A species of gram-positive, aerobic bacteria that causes LEPROSY in man. Its organisms are generally arranged in clumps, rounded masses, or in groups of bacilli side by side.Mice, Inbred BALB CVitiligo: A disorder consisting of areas of macular depigmentation, commonly on extensor aspects of extremities, on the face or neck, and in skin folds. Age of onset is often in young adulthood and the condition tends to progress gradually with lesions enlarging and extending until a quiescent state is reached.Sunlight: Irradiation directly from the sun.Facial DermatosesClarithromycin: A semisynthetic macrolide antibiotic derived from ERYTHROMYCIN that is active against a variety of microorganisms. It can inhibit PROTEIN SYNTHESIS in BACTERIA by reversibly binding to the 50S ribosomal subunits. This inhibits the translocation of aminoacyl transfer-RNA and prevents peptide chain elongation.Leprosy, Paucibacillary: A form of LEPROSY classified by the World Health Organization for the purpose of treatment, based on clinical manifestations and skin smear results. Patients with paucibacillary leprosy have fewer than six skin lesions with no causative agent MYCOBACTERIUM LEPRAE on any slit-skin smear testing. Paucibacillary leprosy encompasses indeterminate, borderline tuberculoid, and tuberculoid leprosy.Triple Negative Breast Neoplasms: Breast neoplasms that do not express ESTROGEN RECEPTORS; PROGESTERONE RECEPTORS; and do not overexpress the NEU RECEPTOR/HER-2 PROTO-ONCOGENE PROTEIN.Receptors, Progesterone: Specific proteins found in or on cells of progesterone target tissues that specifically combine with progesterone. The cytosol progesterone-receptor complex then associates with the nucleic acids to initiate protein synthesis. There are two kinds of progesterone receptors, A and B. Both are induced by estrogen and have short half-lives.Breast Neoplasms: Tumors or cancer of the human BREAST.Mycobacterium avium subsp. paratuberculosis: A subspecies of gram-positive, aerobic bacteria. It is the etiologic agent of Johne's disease (PARATUBERCULOSIS), a chronic GASTROENTERITIS in RUMINANTS.Paratuberculosis: A chronic GASTROENTERITIS in RUMINANTS caused by MYCOBACTERIUM AVIUM SUBSPECIES PARATUBERCULOSIS.Crohn Disease: A chronic transmural inflammation that may involve any part of the DIGESTIVE TRACT from MOUTH to ANUS, mostly found in the ILEUM, the CECUM, and the COLON. In Crohn disease, the inflammation, extending through the intestinal wall from the MUCOSA to the serosa, is characteristically asymmetric and segmental. Epithelioid GRANULOMAS may be seen in some patients.Pharmaceutical Services, Online: Pharmacy services accessed via electronic means.Counterfeit Drugs: Drugs manufactured and sold with the intent to misrepresent its origin, authenticity, chemical composition, and or efficacy. Counterfeit drugs may contain inappropriate quantities of ingredients not listed on the label or package. In order to further deceive the consumer, the packaging, container, or labeling, may be inaccurate, incorrect, or fake.Legislation, Pharmacy: Laws and regulations, pertaining to the field of pharmacy, proposed for enactment or enacted by a legislative body.Felidae: The cat family in the order CARNIVORA comprised of muscular, deep-chested terrestrial carnivores with a highly predatory lifestyle.Clopenthixol: A thioxanthene with therapeutic actions similar to the phenothiazine antipsychotics. It is an antagonist at D1 and D2 dopamine receptors.Acebutolol: A cardioselective beta-1 adrenergic antagonist with little effect on the bronchial receptors. The drug has stabilizing and quinidine-like effects on cardiac rhythm, as well as weak inherent sympathomimetic action.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Aclarubicin: An anthracycline produced by Streptomyces galilaeus. It has potent antineoplastic activity.IndiaAmphotericin B: Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.Atovaquone: A hydroxynaphthoquinone that has antimicrobial activity and is being used in antimalarial protocols.Bithionol: Halogenated anti-infective agent that is used against trematode and cestode infestations.Proguanil: A biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent.Colloids: Two-phase systems in which one is uniformly dispersed in another as particles small enough so they cannot be filtered or will not settle out. The dispersing or continuous phase or medium envelops the particles of the discontinuous phase. All three states of matter can form colloids among each other.Laboratories: Facilities equipped to carry out investigative procedures.Laboratories, Hospital: Hospital facilities equipped to carry out investigative procedures.Clinical Laboratory Techniques: Techniques used to carry out clinical investigative procedures in the diagnosis and therapy of disease.Point-of-Care Systems: Laboratory and other services provided to patients at the bedside. These include diagnostic and laboratory testing using automated information entry.Colorado

Successful short-term suppression of clarithromycin-resistant Mycobacterium avium complex bacteremia in AIDS. California Collaborative Treatment Group. (1/98)

During a randomized study of clarithromycin plus clofazimine with or without ethambutol in patients with AIDS and Mycobacterium avium complex (MAC) bacteremia, eight participants received additional antimycobacterial drugs following the detection of a clarithromycin-resistant isolate (MIC, > 8 micrograms/mL). A macrolide (seven received clarithromycin, one azithromycin) and clofazimine were continued; additional treatment included various combinations of ethambutol, ciprofloxacin, amikacin, and rifabutin. After the detection of a resistant isolate and before receipt of additional antimycobacterials, the median peak MAC colony count in blood was 105 cfu/mL (range, 8-81,500 cfu/mL). After additional antimycobacterials, the median nadir MAC colony count was 5 cfu/mL (range, 0-110 cfu/mL). Five (63%) of eight patients had a > or = 1 log10 decrease, including two who achieved negative blood cultures; all of these responses occurred in patients originally assigned to clarithromycin plus clofazimine. Treatment of clarithromycin-resistant MAC bacteremia that emerges during clarithromycin-based treatment can decrease levels of bacteremia and transiently sterilize blood cultures.  (+info)

Antimycobacterial activities of riminophenazines. (2/98)

Riminophenazines were specifically developed as drugs active against Mycobacterium tuberculosis but extensive research over several decades has shown that these compounds are also active against many other mycobacterial infections, particularly those caused by Mycobacterium leprae and the Mycobacterium avium complex (MAC). Clofazimine, the lead compound in this series, is included in the regimens that are approved by the WHO for the treatment of leprosy and has contributed significantly to the control of that disease, particularly that caused by dapsone-resistant bacteria. Despite early problems, clofazimine has shown clinical efficacy in tuberculosis, in particular that caused by multiple drug resistant strains. Clofazimine does not induce resistance and also inhibits emergence of resistance to isoniazid in M. tuberculosis. The efficacy of clofazimine against MAC is more varied and the availability of better drugs has limited its use. Newer riminophenazines, such as B746 and B4157, not only showed increased anti-mycobacterial activity but also produced less skin pigmentation, which is the main drawback of this group of compounds. The most important virtues of riminophenazines, such as intracellular accumulation in mononuclear phagocytic cells, anti-inflammatory activity, a low incidence of drug resistance and slow metabolic elimination, make them attractive candidates for the treatment of mycobacterial infections. It is essential, however, to investigate the newer analogues clinically, while continuing the pursuit of alternate candidates that demonstrate higher anti-mycobacterial activity and lower rates of skin pigmentation.  (+info)

Effective treatment of acute and chronic murine tuberculosis with liposome-encapsulated clofazimine. (3/98)

The therapeutic efficacy of liposomal clofazimine (L-CLF) was studied in mice infected with Mycobacterium tuberculosis Erdman. Groups of mice were treated with either free clofazimine (F-CLF), L-CLF, or empty liposomes twice a week for five treatments beginning on day 1 (acute), day 21 (established), or day 90 (chronic) postinfection. One day after the last treatment, the numbers of CFU of M. tuberculosis in the spleen, liver, and lungs were determined. F-CLF at the maximum tolerated dose of 5 mg/kg of body weight was ineffective; however, 10-fold-higher doses of L-CLF demonstrated a dose response with significant CFU reduction in all tissues without any toxic effects. In acutely infected mice, 50 mg of L-CLF/kg reduced CFU 2 to 3 log units in all three organs. In established or chronic infection, treated mice showed no detectable CFU in the spleen or liver and 1- to 2-log-unit reduction in the lungs. A second series of L-CLF treatments cleared M. tuberculosis in all three tissues. L-CLF appears to be bactericidal in the liver and spleen, which remained negative for M. tuberculosis growth for 2 months. Thus, L-CLF could be useful in the treatment of tuberculosis.  (+info)

A prospective randomized trial of four three-drug regimens in the treatment of disseminated Mycobacterium avium complex disease in AIDS patients: excess mortality associated with high-dose clarithromycin. Terry Beirn Community Programs for Clinical Research on AIDS. (4/98)

The optimal regimen for treatment of Mycobacterium avium complex (MAC) disease has not been established. Eighty-five AIDS patients with disseminated MAC disease were randomized to receive a three-drug regimen of clarithromycin, rifabutin or clofazimine, and ethambutol. Two dosages of clarithromycin, 500 or 1,000 mg twice daily (b.i.d.), were compared. The Data and Safety Monitoring Board recommended discontinuation of the clarithromycin dosage comparison and continuation of the rifabutin vs. clofazimine comparison. After a mean follow-up of 4.5 months, 10 (22%) of 45 patients receiving clarithromycin at 500 mg b.i.d. had died (70 deaths per 100 person-years) compared with 17 (43%) of 40 patients receiving clarithromycin at 1,000 mg b.i.d. (158 deaths per 100 person-years) (relative risk, 2.43; 95% confidence interval, 1.11-5.34; P = .02). After 10.4 months, 20 (49%) of 41 patients receiving rifabutin had died (81 deaths per 100 person-years) compared with 23 (52%) of 44 patients receiving clofazimine (94 deaths per 100 person-years) (relative risk, 1.20; 95% confidence interval, 0.65-2.19; P = .56). Bacteriologic outcomes were similar among treatment groups. In treating MAC disease in AIDS patients, the maximum dose of clarithromycin should be 500 mg b.i.d.  (+info)

Inhibition of potassium transport and growth of mycobacteria exposed to clofazimine and B669 is associated with a calcium-independent increase in microbial phospholipase A2 activity. (5/98)

Altered phospholipase A2 (PLA2) activity and its relationship to cation (K+, Ca2+) uptake and growth were investigated in mycobacteria exposed to the riminophenazine antimicrobial agents, clofazimine and B669 (0.15-2.5 mg/L). Microbial PLA2 activity was measured using a radiometric thin-layer chromatography procedure, whereas K+ and Ca2+ transport were measured using 86Rb+ or 42K+ and 45Ca2+, respectively. Short-term exposure (15-30 min) of Mycobacterium aurum A+ or the virulent and avirulent isolates of Mycobacterium tuberculosis H37R to the riminophenazines resulted in dose-related enhancement of microbial PLA2 activity, which was associated with inhibition of K+ influx and growth. Uptake of Ca2+ by mycobacteria was unaffected, or minimally affected, by the riminophenazines at concentrations of < or = 0.6 mg/L, whereas higher concentrations resulted in increased uptake of the cation in the setting of decreased microbial ATP concentrations. The results of kinetic studies using a fixed concentration (2.5 mg/L) of B669 demonstrated that riminophenazine-mediated enhancement of PLA2 activity and inhibition of K+ uptake in mycobacteria are rapid and probably related events that precede, by several minutes, any detectable effects on microbial ATP concentrations and uptake of Ca2+. Inclusion of the extracellular and intracellular Ca2+-chelating agents EGTA (0.2-7.2 g/L) and BAPTA/FURA-2 (0.2-9.5 mg/L), individually or in combination, did not prevent the effects of B669 on mycobacterial PLA2 activity or K+ transport, whereas alpha-tocopherol, which neutralizes PLA2 primary hydrolysis products, antagonized the inhibitory effects of the riminophenazines on microbial K+ uptake and growth. These results demonstrate that the antimycobacterial activities of clofazimine and B669 are related to a Ca2+-independent increase in mycobacterial PLA2, leading to interference with microbial K+ transport.  (+info)

Preparation of a clofazimine nanosuspension for intravenous use and evaluation of its therapeutic efficacy in murine Mycobacterium avium infection. (6/98)

Clofazimine nanosuspensions were produced by high pressure homogenization and the formulation was optimized for lyophilization. Characterization of the product by photon correlation spectroscopy, laser diffraction and Coulter counter analysis showed that the clofazimine nanosuspensions were suitable for iv injection with a particle size permitting passive targeting to the reticuloendothelial system. Following iv administration to mice of either the nanocrystalline or a control liposomal formulation at a dose of 20 mg clofazimine/kg bodyweight, drug concentrations in livers, spleens and lungs reached comparably high concentrations, well in excess of the MIC for most Mycobacterium avium strains. When C57BL/6 mice were experimentally infected with M. avium strain TMC 724, nanocrystalline clofazimine was as effective as liposomal clofazimine in reducing bacterial loads in the liver, spleen and lungs of infected mice. Nanocrystalline suspensions of poorly soluble drugs such as riminophenazines are easy to prepare and to lyophilize for extended storage and represent a promising new drug formulation for intravenous therapy of mycobacterial infections.  (+info)

Activity of a new class of isonicotinoylhydrazones used alone and in combination with isoniazid, rifampicin, ethambutol, para-aminosalicylic acid and clofazimine against Mycobacterium tuberculosis. (7/98)

The activities of six derivatives of a new class of isonicotinoylhydrazones were investigated in vitro against Mycobacterium tuberculosis H37Rv ATCC 27294, isoniazid-resistant M. tuberculosis ATCC 35822, rifampicin-resistant ATCC 35838, pyrazinamide-resistant ATCC 35828, streptomycin-resistant ATCC 35820 and 16 clinical isolates of M. tuberculosis. Several compounds showed interesting antimycobacterial activity against both ATCC strains and clinical isolates, but were less active against isoniazid-resistant M. tuberculosis. Combinations of five isonicotinoylhydrazone derivatives and rifampicin, ethambutol, para-aminosalicylic acid, isoniazid and clofazimine were also investigated against M. tuberculosis H37Rv ATCC 27294 and against ATCC drug-resistant strains. Addition of sub-MICs of some isonicotinoylhydrazone derivatives resulted in a four- to 16-fold reduction in MICs of ethambutol, para-aminosalicylic acid and rifampicin with fractional inhibitory concentrations (FICs) ranging between 0.17 and 0.37, suggesting a synergic interaction against M. tuberculosis H37Rv. Increased activity was also observed with other combinations (FICs 0.53-0.75), including isoniazid, and a synergic interaction between one of the isonicotinoylhydrazone derivatives and isoniazid (FIC 0.26) was shown against isoniazid-resistant M. tuberculosis ATCC 35822, whereas no effects were observed on combining the isonicotinoylhydrazones with clofazimine. The ability of isonicotinoylhydrazones to inhibit specifically the growth of M. tuberculosis, the high selectivity index and their ability to enhance the activity of standard antituberculous drugs in vitro indicate that they may serve as promising lead compounds for future drug development for the treatment of M. tuberculosis infections.  (+info)

Oxidative stress increases susceptibility of Mycobacterium tuberculosis to isoniazid. (8/98)

Isoniazid is a first-line antibiotic used in the treatment of infections caused by Mycobacterium tuberculosis. Isoniazid is a prodrug requiring oxidative activation by the catalase-peroxidase hemoprotein, KatG. Resistance to isoniazid can be obtained by point mutations in the katG gene, with one of the most common being a threonine-for-serine substitution at position 315 (S315T). The S315T mutation is found in more than 50% of isoniazid-resistant clinical isolates and results in an approximately 200-fold increase in the MIC of isoniazid compared to that for M. tuberculosis H37Rv. In the present study we investigated the hypothesis that superoxide plays a role in KatG-mediated isoniazid activation. Plumbagin and clofazimine, compounds capable of generating superoxide anion, resulted in a lower MIC of isoniazid for M. tuberculosis H37Rv and a strain carrying the S315T mutation. These agents did not cause as great of an increase in isoniazid susceptibility in the mutant strain when the susceptibilities were assessed by using the inhibitory concentration that causes a 50% decrease in growth. These results provide evidence that superoxide can play a role in isoniazid activation. Since clofazimine alone has antitubercular activity, the observation of synergism between clofazimine and isoniazid raises the interesting possibility of using both drugs in combination to treat M. tuberculosis infections.  (+info)

*Clofazimine

... is a phenazine dye and believed to work by interfering with DNA. Clofazimine was approved for medical use in the ... Clofazimine is marketed under the trade name Lamprene by Novartis. One of the world's only producers of the clofazimine ... Clofazimine is also a FIASMA (functional inhibitor of acid sphingomyelinase). Clofazimine has a biological half life of about ... Macrophages were first reported to be inhibited due to the stabilization of lysosomal membrane by clofazimine. Clofazimine also ...

*KCNA3

... progesterone and the anti-lepromatous drug clofazimine). Interestingly, the Kv1.3 blocker clofazimine has been reported to be ... "Clofazimine inhibits human Kv1.3 potassium channel by perturbing calcium oscillation in T lymphocytes". PLoS ONE. 3 (12): e4009 ... Furthermore, clofazimine in combination with the antibiotics clarithromycin and rifabutin induced remission for about 2 years ... Arbiser JL, Moschella SL (February 1995). "Clofazimine: a review of its medical uses and mechanisms of action". J. Am. Acad. ...

*Multi-drug-resistant tuberculosis

imipenem co-amoxiclav clofazimine prochlorperazine metronidazole On December 28, 2012 the U.S. Food and Drug Administration ( ... Jagannath, C; Reddy, M V; Kailasam, S; O'Sullivan, J F; Gangadharam, P R (1995). "Chemotherapeutic activity of clofazimine and ... Janulionis, E.; Sofer, C.; Song, H.-Y.; Wallis, R. S. (2004). "Lack of Activity of Orally Administered Clofazimine against ... "Effective Treatment of Acute and Chronic Murine Tuberculosis with Liposome-Encapsulated Clofazimine". Antimicrobial Agents and ...

*Leprostatic agent

Clofazimine is a weakly bactericidal dye that has some activity against M. leprae. Its precise mechanism of action is unknown ... Clofazimine is given to treat sulfone-resistant leprosy or to patients who are intolerant to sulfones. It also exerts an ... Clofazimine achieves significant concentrations in tissues, including the phagocytic cells; it has a plasma half-life of 70 ... The most disturbing adverse reaction to clofazimine is a red-brown discoloration of the skin, especially in light-skinned ...

*Febrile neutrophilic dermatosis

Other alternatives to corticosteroid treatment include dapsone, doxycycline, clofazimine, and cyclosporine. All of these drugs ...

*Stanley George Browne

While in Nigeria, he pioneered the use of anti-leprosy drug, clofazimine. Browne returned to England 1965 and used his vast ...

*Management of Crohn's disease

Rifabutin, clarithromycin and clofazimine are antibiotics designed to attack mycobacterium avium subsp. paratuberculosis, which ...

*Rifabutin

"Two-year combination antibiotic therapy with clarithromycin, rifabutin, and clofazimine for Crohn's disease". Gastroenterology ...

*Promin

Today, the drugs of choice for treating leprosy are dapsone, rifampicin and clofazimine. Leo B. Slater (2009). War and disease ...

*Bedaquiline

Other medications for tuberculosis that can prolong the QT interval include fluoroquinolones and clofazimine. Bedaquiline ...

*Vincent Barry

He is known for leading the team which developed the anti-leprosy drug clofazimine. Barry was born in Sunday's Well, Cork. He ... He led a team of scientists at Trinity College, Dublin to discover the anti-leprosy drug clofazimine. Barry and his team were ...

*Dapsone

... is commonly used in combination with rifampicin and clofazimine for the treatment of leprosy. It is also used to both ... is an antibiotic commonly used in combination with rifampicin and clofazimine for the treatment of leprosy. It is a second-line ...

*Cheilitis

Clofazimine, Clomipramine, Cyancobalamin, Gold, Methyldopa, Psoralens, Streptomycin, Sulfasalazine and Tetracycline. A ...

*Giaconda (pharmaceutical company)

... clarithromycin and clofazimine. The combination is envisaged as a new treatment for Crohn's Disease. Myoconda was first devised ...

*Thazhakkara

It is also one of the only companies in the world to manufacture clofazimine[citation needed]. [1]. ...

*Lacazia

While there yet appears no optional medical therapy, clofazimine has been effective in some cases with lobomycosis. It is a ...

*Mycobacterium leprae

... rifampicin and clofazimine. In patients receiving the MDT, a high proportion of the bacilli die within a short amount of time ...

*Timeline of Irish inventions and discoveries

1954: Clofazimine first synthesized by a medical research team led by Cork man Vincent Barry at Trinity College, Dublin. 1965: ...

*History of leprosy

The search for more effective anti-leprosy drugs led to the use of clofazimine and rifampicin in the 1960s and 1970s. Later, ... The search for additional anti-leprosy drugs led to the use of clofazimine and rifampicin in the 1960s and 1970s. Later, Indian ...

*Lucio's phenomenon

... is treated by anti-leprosy therapy (dapsone, rifampin, and clofazimine), optimal wound care, and treatment ...

*Diffuse leprosy of Lucio and Latapí

Lucio's phenomenon is treated by anti-leprosy therapy (dapsone, rifampin, and clofazimine), optimal wound care, and treatment ...

*London Declaration on Neglected Tropical Diseases

... clofazimine and dapsone) to eradicate leprosy. Pfizer: A New York-based American multinational pharmaceutical corporation will ...

*Mycobacterium avium-intracellulare infection

Many clinicians have added one or more of the following as second, third, or fourth agents: clofazimine, rifabutin, rifampin, ...

*Rifampicin

... rifampicin is always used in combination with dapsone and clofazimine to avoid causing drug resistance. Rifampicin is sometimes ...

*Lobomycosis

Treatment with antifungals has been considered ineffective, but the use of clofazimine and dapsone in patients with leprosy and ...
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Wnt signaling is overactivated in triple-negative breast cancer (TNBC) and several other cancers, and its suppression emerges as an effective anticancer treatment. However, no drugs targeting the Wnt pathway exist on the market nor in advanced clinical trials. Here we provide a comprehensive body of preclinical evidence that an anti-leprotic drug clofazimine is effective against TNBC. Clofazimine specifically inhibits canonical Wnt signaling in a panel of TNBC cells in vitro. In several mouse xenograft models of TNBC, clofazimine efficiently suppresses tumor growth, correlating with in vivo inhibition of the Wnt pathway in the tumors. Clofazimine is well compatible with doxorubicin, exerting additive effects on tumor growth suppression, producing no adverse effects. Its excellent and well-characterized pharmacokinetics profile, lack of serious adverse effects at moderate (yet therapeutically effective) doses, its combinability with cytotoxic therapeutics, and the novel mechanistic mode
Background & Aims: Mycobacterium avium subspecies paratuberculosis has been proposed as a cause of Crohns disease. We report a prospective, parallel, placebo-controlled, double-blind, randomized trial of 2 years of clarithromycin, rifabutin, and clofazimine in active Crohns disease, with a further year of follow-up. Methods: Two hundred thirteen patients were randomized to clarithromycin 750 mg/day, rifabutin 450 mg/day, clofazimine 50 mg/day or placebo, in addition to a 16-week tapering course of prednisolone. Those in remission (Crohns Disease Activity Index ≤150) at week 16 continued their study medications in the maintenance phase of the trial. Primary end points were the proportion of patients experiencing at least 1 relapse at 12, 24, and 36 months. Results: At week 16, there were significantly more subjects in remission in the antibiotic arm (66%) than the placebo arm (50%; P = .02). Of 122 subjects entering the maintenance phase, 39% taking antibiotics experienced at least 1 relapse ...
PRIMARY: To assess the tolerability of the combination regimen of clarithromycin plus ethambutol with or without clofazimine in patients with disseminated Mycobacterium avium Complex (dMAC).. SECONDARY: To determine the proportion of patients achieving a sterile blood culture along with the time required to achieve it. To determine the duration of bacteriological response, defined as length of time that blood cultures remain sterile. ...
Abstract A pharmacologic study of clofazimine (B663) was carried out in mice and human subjects to provide information needed for interpretation of data from studies of drug action in the two species. The quantities of B663 in mouse carcasses were measured to determine the half-time of disappearance (t ½) of the drug and the absorption of the drug after oral administration. The antimicrobial activity of orally-administered B663 was studied in mice infected with Mycobacterium leprae and correlated with the quantity of B663 in the carcass. Published studies of the effect of the drug in murine infections with M. leprae and M. tuberculosis were reinterpreted. The t ½ of B663 is about 1 week in male BALB/c mice. The antimicrobial effect of the drug appears to require a concentration in the mouse carcass smaller than 1 mg/kg for M. leprae and greater than 5 to 10 mg/kg for M. tuberculosis. The concentration of B663 was also measured in the plasma, urine and feces of volunteers and leprosy patients. The t ½
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Considerable re-pigmentation of vitiliginous skin occurred in 8 White female patients who were treated with clofazimine and exposed to natural sunlight.
Prof Harvey Rubin in his plenary address on Wednesday morning 4 July discussed new findings about the action of clofazimine. This is a standard treatment for leprosy, but through its selective action of starving bacterial cells of energy, it is effective in vitro against Mycobacterium tuberculosis and some other bacteria, including Staphylococcus aureus. He says trials will commence soon to test clofazimine in people with multidrug resistant TB. This may be a major advance in battling the severe emerging global problem of drug resistant TB.. Visit the ASM 2012 Meeting website.. Mutidrug Resistance TB (World Health Organization) site: excellent resource! ...
Sigma-Aldrich offers abstracts and full-text articles by [A V Koval, P Vlasov, P Shichkova, S Khunderyakova, Y Markov, J Panchenko, A Volodina, F A Kondrashov, V L Katanaev].
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Scientists wanted BDQ to work more efficiently against TB, so they looked for a way to fix the problem caused by the efflux pump. They found that when BDQ was given in combination with specific drugs, like efflux pump inhibitors, the amount of the drug needed to fight the bacteria decreased. This is a good thing because you would like to treat the infection with the lowest concentration of drugs possible.. It turns out that the pump mutation worked against the treatment because it caused the pump to move BDQ out of the cell. Efflux inhibitor drugs slow down the efflux of antibiotics like BDQ. As the efflux pump inhibitors slow down the pumps, BDQ is able to finally do its job - to kill the TB cells. Finding out what mutation was affecting BDQ and identifying drugs that solved the problem helped scientists move on to the next step of testing.. The scientists tested a few other drugs to see if they could be used with BDQ to improve its effect on TB. They found that a drug called clofazimine (CFZ) ...
This phase I trial investigated the the effects of food on the pharmacokinetics on each of the components of RHB 104 [clarithromycin/clofazimine/rifabutin], and
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This years Big Schools Birdwatch was the best yet: we had a record number of species but also an amazing amount of enthusiasm amongst the pupils! It was an icy cold day, but the children turned up with coats, hats, scarves and gloves and even binoculars, ready to see what we could find. Once the birdwatch was over we used the results for making graphs in maths, making an information book about the birds we found and presented an assembly to spread the good news! Ive already had requests to do it again next year ...
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Enter the appropriate data on the Input Data page. If necessary, you may change the default data that automatically appears in the input fields.. All of the WHITE cells must contain input data for the model to work. If fields are left blank or as zeros the data will not be complete. Not a number (NaN) and infinity values indicate an error.. The system airflow rate is set at a default equal to 2000cfm multiplied by # of Filters. The system airflow rate appears when you enter a value in the # of Filters field. To change this default, simply enter the actual system airflow in this field and do not change the # of Filters field.. To clear all fields and reset the inputs to their defaults, use the Clear All button. To reset only the input fields, use the Default Input button.. ...
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In an effort to improve treatment outcomes and shorten treatment duration, TB drug research has been aiming at redevelopment of existing first-line TB drugs (high dose rifamycins and pyrazinamide) and repurposing of available antibiotics (e.g. moxifloxacin, linezolid and clofazimine), alongside the development of new compounds (e.g. bedaquiline, delamanid, SQ109). The advantage of redeveloping and repurposing…. Read more Drug development ...
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Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
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Rotoroa Island, off the coast of New Zealand is tiny, at just 82 hectares (200 acres), but dont let its diminutiveness fool you: big things are happening here. Over the past few years the island has become the site of a quiet, but grand, conservation experiment. What would happen if you populated an island with a whole suite of endangered species, some of which were never found there to begin with? And what would happen if you didnt fence the island off and keep pesky humans out, but let people - school groups even - tramp through the grounds? ...
As regular CFZ-watchers will know, for some time Corinna has been doing a column for Animals & Men and a regular segment on On The Track... particularly about out-of-place birds and rare vagrants. There seem to be more and more bird stories from all over the world hitting the news these days so, to make room for them all - and to give them all equal and worthy coverage - she has set up this new blog to cover all things feathery and Fortean. ...
As regular CFZ-watchers will know, for some time Corinna has been doing a column for Animals & Men and a regular segment on On The Track... particularly about out-of-place birds and rare vagrants. There seem to be more and more bird stories from all over the world hitting the news these days so, to make room for them all - and to give them all equal and worthy coverage - she has set up this new blog to cover all things feathery and Fortean. ...
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TY - JOUR. T1 - Newer drugs and targets in tuberculosis. AU - Subramanian, Harish Thanu. AU - Meena Kumari, K.. AU - Amberkar Mohan Babu, V.. PY - 2016/1/1. Y1 - 2016/1/1. N2 - In the year 2013, nine million people suffered from tuberculosis. Around 1.5 million people (men, woman and children) died due to tuberculosis. About 1.1 million people with HIV developed tuberculosis. The major drawbacks of tuberculosis treatment in a patient are multidrug resistant tuberculosis (MDR-TB) and extensively drug resistant tuberculosis (XDR-TB). Recently newer drugs and targets have been the key focus of research in finding the permanent cure for tuberculosis. The FDA has recently approved a new tuberculosis drug bedaquiline. The drugs under trials are delamanid, pretomanid, sutezolid and SQ109. Drugs in preclinical development showing promising results are benzothiazinone, spectinamide, capuramycin, TBI-166 (Riminophenazines antibiotic). The various lead compounds which showed promising activity against ...
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Chemical force microscopy (CFM) is a variation of atomic force microscopy (AFM) which has become a versatile tool for characterization of materials surfaces. With AFM, structural morphology is probed using simple tapping or contact modes that utilize van der Waals interactions between tip and sample to maintain a constant probe deflection amplitude (constant force mode) or maintain height while measuring tip deflection (constant height mode). CFM, on the other hand, uses chemical interactions between functionalized probe tip and sample. Choice chemistry is typically gold-coated tip and surface with R-SH thiols attached, R being the functional groups of interest. CFM enables the ability to determine the chemical nature of surfaces, irrespective of their specific morphology, and facilitates studies of basic chemical bonding enthalpy and surface energy. Typically, CFM is limited by thermal vibrations within the cantilever holding the probe. This limits force measurement resolution to ~1 pN which is ...
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As regular CFZ-watchers will know, for some time Corinna has been doing a column for Animals & Men and a regular segment on On The Track... particularly about out-of-place birds and rare vagrants. There seem to be more and more bird stories from all over the world hitting the news these days so, to make room for them all - and to give them all equal and worthy coverage - she has set up this new blog to cover all things feathery and Fortean. ...
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With the rising use of high-stakes tests has come a backlash. Critics say many students would sooner drop out of school, possibly to take the General Educational Development test, than face an exam they feel sure they will fail. Includes: Study Says to States: Dont Rush; Provide Support on Exit Exams.
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An article about Sen. John McCains presidential campaign, McCains Views on Schools Becoming Clearer, in the Feb. 16, 2000, print edition of Education Week incorrectly identified Gary Huggins, the executive director of the Education Leaders Council, as an adviser to the campaign. Although he has met with campaign officials to discuss education policy, he is not serving as an adviser.
Leprosy, a chronic infectious disease, is caused by an obligate intracellular pathogen- Mycobacterium leprae (M. leprae). Although the prevalence of this disease has significantly gone down after the introduction of WHO regimen of Multidrug Therapy (MDT), the incidence remains a constant peril with approximately 211, 973 cases reported globally in 2015 out of which 127,334 cases were reported from India alone 1,2. Multi-drug therapy (MDT) includes Rifampicin (RIF), Dapsone and Clofazimine in 1982 by WHO 3. RIF is being used for the treatment of mycobacterial diseases such as tuberculosis and leprosy due to its efficient antimicrobial action. However, after its use for more than 3 decades drug resistance to RIF in leprosy is being reported4-8. Considering that the resistance to RIF might pose a problem in the treatment of leprosy, a study on RIF and its interaction with resistant M. leprae mutants at the level of structure and function of bacterial DNA-dependent RNA polymerase (RNAP) and its ...
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HMV3053U Bosch 300 Series 30 Over the Range Microwave with 300 CFM Ventilation and 2-Speed Fan - Stainless SteelThis precisely designed over-the-range microwave oven by Bosch is a perfect match to the sleek design of Boschs line of kitchen products. The microwave offer a capacity of 1.6 cubic feet for cooking large items. Below the microwave is a 300 CFM ventilation system with two speeds and cooktop lighting. Ventilation can be exhausted to the exterior of your home, or air can be recirculated in kitchens that cant reach the exterior.FeaturesA Large Cooking Interior Gives You Flexibility to Cook Various DishesA Multi-Speed Vent Efficiently Removes Steam, Smoke, Grease and OdorsAutomatic Defrost Determines Power Level and Cooking TimeThe LCD Display Features Easy-to-Read White LED LetteringThe OTR Microwave is Designed to Install With a Bosch Slide-in Range or Cooktop.1.6 Cu. Ft. Oven CapacitySeamless Vent Cover Makes Clean Up a BreezeRecirculation or Outside Venting Options - Up to 300 CFM1,000
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This type of ventilation uses fans, inlets, controls and roof exhausters in a pressure-controlled environment. Mechanical ventilation may also be required when there are structures such as bleachers or posts that may impede natural air flow through the building. The amount of artificial ventilation required also depends on climate and the number of horses in your barn.. A 2003 study1 by Penn States Dr. Eileen Fabian Wheeler - an associate professor of agricultural and biological engineering - suggests minimum recommendations on how much ventilation is required for every 1,000-pound horse. A fans power is determined by how many cubic feet of air it can exchange per minute (cfm). In cold temperatures, you will require a fan with at least a 25 cfm rating for effective moisture control. Mild weather requires fans with a 100 cfm rating for heat removal, while hot temperatures require fans with 200 - 350 cfm ratings.. There are three types of fans that can be used to achieve this.. Circulation Fans ...
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Projections for the future of the epidemic have most often taken the form of trying to estimate how many new AIDS cases will be diagnosed (or reported) over some span of future years. AIDS cases can be projected in one of three ways. First, the numbers of recent AIDS cases can simply be extrapolated forward by using various regression techniques to model past trends and extend the model forward.(32) This approach was used for estimating the number of cases in the next 2 to 3 years with pretty good validity because the number of AIDS cases did not change rapidly from year to year in the past due to the long incubation period from infection to AIDS. Rapid changes in the incubation period due to the introduction of effective multi-drug therapy have rendered this technique not very useful in the 1995 to 1997 period when the new treatments were being introduced. Artifactual changes, such as new case definitions, are another source of sudden change in the number of cases, but otherwise, changes tend ...
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How much airflow per square centimeter do they generate? As for the cluster here plenty of space available. To rent office space is around a 50 euro a square meter a year over here, not sure about there. So the cluster, some cardboard and huge fans of 14 and 18 CM are diong the job to cool the nodes and switch, mellanox of course. now as i understand the square meters they reserve for datacenters is always far too limited, causing space each node eats as important as well, yet thats not the problem here in my office. The thing that worries me more is the airflow to outside (and inside). Usually only have limited amount of square centimeters of tube there. The industrial fans that have massive airflow, theyre very very noisy. Im already wondering about using some massive cardboard box and blow in air there using 8 fans (@ 100CFM each) or so and then behind them a second layer of fans, around 6 @ 100CFM, creating a massive overpressure, hoping that this will generate more airpressure, enough ...
HARLINGEN - For the last four and a half months, a baby endured abuse that included two fractured bones in his left arm, another fracture in his right arm, a broken leg and bruises to his jaw, abdomen and thighs. Now the babys mother and her boyfriend are accused of causing those and other injuries to the baby, as well as feeding the baby spoiled, raw meat. http://www.themonitor.com/SiteProcessor.cfm?Template=/GlobalTemplates/Details.cfm&StoryID=2635&Section=Local
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The goal of leprosy control program is early detection of patients with this infection, giving them appropriate treatment, and adequate care to prevent disabilities and rehabilitations.. Since leprosy is an infectious disease, antibiotic therapy plays a vital role in treatment. There are many effective chemotherapy agents that act against Mycobacterium leprae.. As per WHO recommendations, dapsone, rifampin, clofazimine, ofloxacin, and minocycline are considered to be the backbone of the multidrug therapy. Other chemotherapeutic drugs include Levofloxacin, sparfloxacin, and clarithromycin. These are also proved to be effective against Mycobacterium leprae.. Diagnosis with multidrug therapy has a key role in the treatment and strategy to eliminate the disease as a public health problem. WHO made this multidrug therapy treatment available free of charge to all patients throughout the world since 1995.. For both Paucibacillary and multibacillary leprosy, rifampin is central for treatment. In the ...
sufate oxidase, would convert all sulfite to sulfate. In addition, the highly charged nature of these ingredients would result in relatively low dermal penetration.. As used in cosmetics and personal care products, the CIR Expert Panel concluded that Sodium Sulfite, Potassium Sulfite, Ammonium Sulfite, Sodium Bisulfite, Sodium Metabisulfite and Potassium Metabisulfte were safe.. FDA: Link to Code of Federal Regulations for Sodium Sulfite, Sodium Bisulfite, Potassium Bisulfite, Sodium Metabisulfite, and Potassium Metabisulfite. http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr.... http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr.... http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr.... http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr.... http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr.... Sodium Sulfite, Potassium Sulfite, and Ammonium Sulfite are listed as inorganic sulphites ...
MAC Infection (Mycobacterium Avium Complex) Clinical Research Trial Listings in Immunology Pulmonary/Respiratory Diseases Hepatology (Liver, Pancreatic, Gall Bladder) Infections and Infectious Diseases on CenterWatch
Dr. Samreen Sarfaraz, Consultant Infectious Diseases, was the speaker of the first CME of the year 2017. She started her presentation with a simple introduction to Hansens Disease also known as Leprosy and that it is closely related to Tuberculosis. She highlighted that Acid-Fast Bacilli (ABF) Smear results in positive for both Tuberculosis and Leprosy but the point of differentiation is growth of the organism, i.e. Mycobacterium leprae does not grow.. Discussing the transmission, she informed that it can occurs through nasal, oral droplets and dermal inoculations. Natural reservoirs include Armadillo, mice, rabbit and some types of monkeys, however, transmission occurs from human to human also. Under the heading of treatment, she discussed about the history acknowledging Dapsone being the first anti-leprotic drug. She also explained the multi-drug therapy currently used to treat Hansens Disease.. ...
Terms of Use The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or ...
SRAC Publication No. 410 Calculating Treatments for Ponds and Tanks. Southern Regional Aquaculture Center. https://srac.tamu.edu/index.cfm/event/getFactSheet/whichfactsheet/83/. SRAC Publication No. 475 Proliferative Gill Disease (Hamburger Gill Disease). Southern Regional Aquaculture Center. https://srac.tamu.edu/index.cfm/event/getFactSheet/whichfactsheet/122/. SRAC Publication No. 4701 Protozoan Parasites. Southern Regional Aquaculture Center. https://srac.tamu.edu/index.cfm/event/getFactSheet/whichfactsheet/171/. UF/IFAS Circular 91 Nematode (Roundworm) Infections in Fish. http://edis.ifas.ufl.edu/FA091. UF/IFAS Circular 120 Fish Health Management Considerations in Recirculating Aquaculture Systems - Part 1: Introduction and General Principles. http://edis.ifas.ufl.edu/FA099. UF/IFAS Circular 121 Fish Health Management Considerations in Recirculating Aquaculture Systems - Part 2: Pathogens. http://edis.ifas.ufl.edu/FA100. UF/IFAS Circular 122 Fish Health Management Considerations in ...

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Detailed drug Information for clofazimine. Includes common brand names, drug descriptions, warnings, side effects and dosing ... When clofazimine is used to treat ``flare-ups of leprosy, it may be given with a cortisone-like medicine. Clofazimine may ... Clofazimine is available only with your doctors prescription.. Before Using clofazimine. In deciding to use a medicine, the ... Uses For clofazimine. Clofazimine is taken to treat leprosy (Hansens disease). It is sometimes given with other medicines for ...
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Clofazimine) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related ... Lamprene (clofazimine) should be taken with meals.. Lamprene (clofazimine) should be used preferably in combination with one or ... Lamprene (clofazimine) exerts a slow bactericidal effect on Mycobacterium leprae (Hansens bacillus). Lamprene (clofazimine) ... Lamprene (clofazimine) is retained in the human body for a long time. The half-life of Lamprene (clofazimine) following ...
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Learn about the potential side effects of clofazimine. Includes common and rare side effects information for consumers and ... Applies to clofazimine: oral capsule. Gastrointestinal. Gastrointestinal (GI) side effects have included clofazimine ... Lamprene (clofazimine)." Novartis Pharmaceuticals, East Hanover, NJ. 14. Oommen T "Clofazimine-induced lymphoedema ." Lepr Rev ... Clofazimine crystalline infiltration in the intestinal and gall bladder mucosa, and in the bile, liver, and spleen have been ...
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Clofazimine Exposure In Vitro Selects Efflux Pump Mutants and Bedaquiline Resistance Six in vitro clofazimine-resistant ... Novel Mutations Associated with Clofazimine Resistance in Mycobacterium abscessus Yuanyuan Chen, Jiazhen Chen, Shuo Zhang, ... Assessment of Clofazimine and TB47 Combination Activity against Mycobacterium abscessus Using a Bioluminescent Approach ... The riminophenazine agent clofazimine (CFZ) is repurposed as an important component of the new short-course multidrug-resistant ...
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Clofazimine is a phenazine dye and believed to work by interfering with DNA. Clofazimine was approved for medical use in the ... Clofazimine is marketed under the trade name Lamprene by Novartis. One of the worlds only producers of the clofazimine ... Clofazimine is also a FIASMA (functional inhibitor of acid sphingomyelinase). Clofazimine has a biological half life of about ... Macrophages were first reported to be inhibited due to the stabilization of lysosomal membrane by clofazimine. Clofazimine also ...
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Bolla G, Nangia A (2012) Clofazimine mesylate: a high solubility stable salt. Cryst Growth Des 12(12):6250-6259CrossRefGoogle ... Narang AS, Srivastava AK (2002) Evaluation of solid dispersions of clofazimine. Drug Dev Ind Pharm 28(8):1001-1013CrossRef ... Patel V, Misra A (1999) Encapsulation and stability of clofazimine liposomes. J Microencapsul 16(3):357-367CrossRefGoogle ... Yano T, Kassovska-Bratinova S, Teh JS, Winkler J, Sullivan K, Isaacs A, Schechter NM, Rubin H (2011) Reduction of clofazimine ...
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Abstract A pharmacologic study of clofazimine (B663) was carried out in mice and human subjects to provide information needed ... A pharmacologic study of clofazimine (B663) was carried out in mice and human subjects to provide information needed for ...
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Frontiers | Clofazimine, but Not Isoniazid or Rifampicin, Augments Platelet Activation in vitro | PharmacologyFrontiers | Clofazimine, but Not Isoniazid or Rifampicin, Augments Platelet Activation in vitro | Pharmacology

Clofazimine, but neither isoniazid nor rifampicin, caused dose-related potentiation of both ADP- and thrombin-activated ... Clofazimine, at concentrations within the therapeutic range, augments platelet activation in vitro, probably by a mechanism ... Clofazimine, but neither isoniazid nor rifampicin, caused dose-related potentiation of both ADP- and thrombin-activated ... Clofazimine, at concentrations within the therapeutic range, augments platelet activation in vitro, probably by a mechanism ...
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Considerable re-pigmentation of vitiliginous skin occurred in 8 White female patients who were treated with clofazimine and ... Keyword(s) : Case report, Clofazimine, Dermatology, Lamprene, Pharmacology, Treatment and Vitilgo * Accreditation : Department ... oa South African Medical Journal - Clofazimine (lamprene) in the treatment of vitiligo * Navigate this Journal ... Considerable re-pigmentation of vitiliginous skin occurred in 8 White female patients who were treated with clofazimine and ...
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Clofazimine - Mechanism, Indication, Contraindications, Dosing, Adverse Effect, Interaction | Drug Index | Pediatric OncallClofazimine - Mechanism, Indication, Contraindications, Dosing, Adverse Effect, Interaction | Drug Index | Pediatric Oncall

Medical information for Clofazimine on Pediatric Oncall including Mechanism, Indication, Contraindications, Dosing, Adverse ... Clofazimine exerts a slow bactericidal effect on Mycobacterium leprae (Hansens bacillus). It inhibits mycobacterial growth and ... Dapsone: May inhibit the anti-inflammatory activity of clofazimine have not been confirmed. If leprosy-associated inflammatory ... conjunctival and corneal pigmentation due to clofazimine crystal deposits, discoloration of urine, faeces, sputum, sweat, ...
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Chemotherapeutic activity of clofazimine and its analogues against Mycobacterium tuberculosis. In vitro, intracellular, and in...Chemotherapeutic activity of clofazimine and its analogues against Mycobacterium tuberculosis. In vitro, intracellular, and in...

Clofazimine (CFM), a riminophenazine drug, is primarily used in therapy for leprosy and Mycobacterium avium infections. With an ... Chemotherapeutic activity of clofazimine and its analogues against Mycobacterium tuberculosis. In vitro, intracellular, and in ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/7697235?dopt=Abstract

clofazimine | Ligand page | IUPHAR/BPS Guide to PHARMACOLOGYclofazimine | Ligand page | IUPHAR/BPS Guide to PHARMACOLOGY

clofazimine ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental drugs. ... Clofazimine: a review of its medical uses and mechanisms of action. J. Am. Acad. Dermatol., 32 (2 Pt 1): 241-7. [PMID:7829710] ... State-dependent blocking mechanism of Kv 1.3 channels by the antimycobacterial drug clofazimine. Br. J. Pharmacol., 172 (21): ...
more infohttp://www.guidetopharmacology.org/GRAC/LigandDisplayForward?tab=refs&ligandId=9184

The Safety and Effectiveness of Clarithromycin Plus Ethambutol Used With or Without Clofazimine in the Treatment of MAC in...The Safety and Effectiveness of Clarithromycin Plus Ethambutol Used With or Without Clofazimine in the Treatment of MAC in...

Clofazimine. Anti-Bacterial Agents. Anti-Infective Agents. Protein Synthesis Inhibitors. Enzyme Inhibitors. Molecular ... The Safety and Effectiveness of Clarithromycin Plus Ethambutol Used With or Without Clofazimine in the Treatment of MAC in ... PRIMARY: To assess the tolerability of the combination regimen of clarithromycin plus ethambutol with or without clofazimine in ... Clarithromycin and ethambutol with or without clofazimine for the treatment of bacteremic Mycobacterium avium complex disease ...
more infohttps://clinicaltrials.gov/show/NCT00002331?order=7

A mutation associated with clofazimine and bedaquiline cross-resistance in MDR-TB following bedaquiline treatment | European...A mutation associated with clofazimine and bedaquiline cross-resistance in MDR-TB following bedaquiline treatment | European...

A mutation associated with clofazimine and bedaquiline cross-resistance in MDR-TB following bedaquiline treatment. Akos ... A mutation associated with clofazimine and bedaquiline cross-resistance in MDR-TB following bedaquiline treatment ... A mutation associated with clofazimine and bedaquiline cross-resistance in MDR-TB following bedaquiline treatment ... A mutation associated with clofazimine and bedaquiline cross-resistance in MDR-TB following bedaquiline treatment ...
more infohttp://erj.ersjournals.com/content/early/2014/10/30/09031936.00142914

Generic Lamprene (Clofazimine 50mg) $ 3.33 pill - Antivirals @ KupTaniaGeneric Lamprene (Clofazimine 50mg) $ 3.33 pill - Antivirals @ KupTania

Clofazimine capsule. What is this medicine?. CLOFAZIMINE is an anti-infective medicine. It is used to treat leprosy. ... Generic Lamprene (Clofazimine) Antivirals. Generic Lamprene is taken to treat leprosy (Hansens disease). It is sometimes given ... an unusual or allergic reaction to clofazimine, other medicines, foods, dyes or preservatives ...
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The American Journal of Tropical Medicine and Hygiene | Clofazimine Therapy of Lepromatous Leprosy Caused by Dapsone-Resistant...The American Journal of Tropical Medicine and Hygiene | Clofazimine Therapy of Lepromatous Leprosy Caused by Dapsone-Resistant...

Five of the patients with dapsone-resistant organisms were treated with clofazimine (B663) in a dose of 100 to 200 mg daily, ... Clofazimine Therapy of Lepromatous Leprosy Caused by Dapsone-Resistant Mycobacterium Leprae * * Louis Levy, Charles C. Shepard ... Five of the patients with dapsone-resistant organisms were treated with clofazimine (B663) in a dose of 100 to 200 mg daily, ...
more infohttp://www.ajtmh.org/content/journals/10.4269/ajtmh.1972.21.315

The Safety and Effectiveness of Clarithromycin Plus Ethambutol Used With or Without Clofazimine in the Treatment of MAC in...The Safety and Effectiveness of Clarithromycin Plus Ethambutol Used With or Without Clofazimine in the Treatment of MAC in...

ClinicalTrials.gov summary of The Safety and Effectiveness of Clarithromycin Plus Ethambutol Used With or Without Clofazimine ... Clofazimine Acquired Immunodeficiency Syndrome Clarithromycin Additional relevant MeSH terms: Infection Communicable Diseases ... Clofazimine ClinicalTrials.gov processed this data on August 16, 2019 This information is provided by ClinicalTrials.gov. ... The Safety and Effectiveness of Clarithromycin Plus Ethambutol Used With or Without Clofazimine in the Treatment of MAC in ...
more infohttps://aidsinfo.nih.gov/clinical-trials/details/NCT00002331

Anti-leprosy drug clofazimine inhibits growth of triple-negative breast cancer cells via inhibition of canonical Wnt signaling....Anti-leprosy drug clofazimine inhibits growth of triple-negative breast cancer cells via inhibition of canonical Wnt signaling....

Anti-leprosy drug clofazimine inhibits growth of triple-negative breast cancer cells via inhibition of canonical Wnt signaling. ... These data provide a basis for further investigations of the efficiency of clofazimine in treatment of Wnt-dependent cancers. ... We further describe the previously unknown inhibitory activity of an anti-leprosy drug clofazimine in the Wnt pathway and ...
more infohttps://www.sigmaaldrich.com/catalog/papers/24355563

Cross-Resistance between Clofazimine and Bedaquiline through Upregulation of MmpL5 in Mycobacterium tuberculosis |...Cross-Resistance between Clofazimine and Bedaquiline through Upregulation of MmpL5 in Mycobacterium tuberculosis |...

... on Middlebrook 7H11 medium containing clofazimine at concentrations only just greater (4×) than its MIC (solid clofazimine MIC ... Cross-Resistance between Clofazimine and Bedaquiline through Upregulation of MmpL5 in Mycobacterium tuberculosis. Ruben C. ... Clofazimine, a riminophenazine, is a standard component of the multidrug therapy used for the treatment of leprosy and has ... To confirm genetically the role of Rv0678(S63R) in resistance to clofazimine and bedaquiline, rv0678(S63R) was expressed from ...
more infohttps://aac.asm.org/content/58/5/2979?ijkey=8897a1ea5a42396b1c7707de88316eab5a0fa192&keytype2=tf_ipsecsha

clofazimine | Ligand page | IUPHAR/BPS Guide to PHARMACOLOGYclofazimine | Ligand page | IUPHAR/BPS Guide to PHARMACOLOGY

clofazimine ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental drugs. ... Clofazimine is a phenazine dye with anti-mycobacterial action (possibly via DNA binding) but is no longer perscribed in the US ... State-dependent block of Kv1.3 channels by clofazimine offers therapeutic potential for selective immunosuppression in the ...
more infohttps://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=9184

Cultured Afb Mycobacterium Rapid Single Clofazimine Test for Tuberculosis | Dr Lal PathLabsCultured Afb Mycobacterium Rapid Single Clofazimine Test for Tuberculosis | Dr Lal PathLabs

Dr Lal PathLabs offers test service for Cultured Afb Mycobacterium Rapid Single Clofazimine Test for checking Tuberculosis. ...
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  • As there is no specific target for ROS, resistance to clofazimine is rare and to our knowledge has never been characterized. (asm.org)
  • Following the passage of an isolated colony (H37Rv CFZ-R1 ) in the absence of antibiotic pressure, resistance to clofazimine was maintained (4- to 8-fold), as determined using the resazurin reduction microplate assay (REMA) ( 3 ) ( Fig. 1 ), suggesting the involvement of a genetic resistance mechanism. (asm.org)
  • Clofazimine is an effective drug active against M. abscessus , but the mechanism of resistance to clofazimine in M. abscessus is unknown. (cdc.gov)
  • We conclude that mutations in MAB_2299c, MAB_1483, and MAB_0540 are the major mechanisms of clofazimine resistance in M. abscessus Future studies are needed to address the role of the identified mutations in clofazimine resistance in M. abscessus Our findings have implications for understanding mechanisms of resistance to clofazimine and for rapid detection of clofazimine resistance in this organism. (cdc.gov)
  • A second de novo round of mutant isolation yielded five further clofazimine-resistant mutants. (asm.org)
  • To investigate the molecular basis of clofazimine resistance in M. abscessus , we isolated 29 M. abscessus mutants resistant to clofazimine and subjected them to whole-genome sequencing to identify possible mutations associated with clofazimine resistance. (cdc.gov)
  • Two identical mutations which are likely to be polymorphisms unrelated to clofazimine resistance were found in MAB_4605c and MAB_4323 in 13 mutants. (cdc.gov)
  • Drug susceptibility of MTB H37Rv (solid circles with solid lines) and H37Rv CFZR1 (solid squares with dashed lines) to clofazimine (A), bedaquiline (B), econazole (C), and moxifloxicin (D) as measured by the resazurin reduction assay. (asm.org)
  • To identify the genetic mutation causing the clofazimine-bedaquiline cross-resistance, the genomes of H37Rv and H37Rv CFZ-R1 were subjected to whole-genome sequencing using Illumina technology. (asm.org)
  • When you are taking clofazimine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. (drugs.com)
  • Using clofazimine with any of the following medicines is usually not recommended, but may be required in some cases. (drugs.com)
  • Using clofazimine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. (drugs.com)
  • Every sick person can chiefly order and then purchase the medicines Clofazimine online no prescription and starts his/her medical cure by this drug according to the physicians' recommendations. (norxtabs.com)
  • Angiolini L, Valetti S, Cohen B, Feiler A, Douhal A (2018) Fluorescence imaging of antibiotic clofazimine encapsulated within mesoporous silica particle carriers: relevance to drug delivery and the effect on its release kinetics. (springer.com)
  • State-dependent block of Kv1.3 channels by clofazimine offers therapeutic potential for selective immunosuppression in the context of autoimmune diseases in which Kv1.3-expressing T cells play a significant role [ 2 ]. (guidetopharmacology.org)
  • Clofazimine produces pink to brownish skin pigmentation in 75-100% of patients within a few weeks, as well as similar discoloration of most bodily fluids and secretions. (wikipedia.org)
  • A pharmaceutically acceptable polymer, alginate, is coated on amorphous clofazimine by electrostatic deposition and effectively inhibits its surface crystallization and enhances its dissolution rate. (springer.com)
  • Clofazimine, but neither isoniazid nor rifampicin, caused dose-related potentiation of both ADP- and thrombin-activated expression of CD62P by platelets, achieving statistical significance at threshold concentrations of 0.625 and 2.5 mg/L, respectively, as well as significant formation of N:P aggregates. (frontiersin.org)
  • Gastrointestinal (GI) side effects have included clofazimine enteropathy. (drugs.com)
  • Following oral administration, clofazimine has a variable absorption ranging from 45% to 62% with 9% to 74% of an administered dose appearing in faeces. (who.int)
  • Faecal elimination of clofazimine exhibits considerable interindividual variation, and 35% to 74% of a single oral dose may be excreted unchanged in faeces over the first 72 hours after the dose. (who.int)
  • Clofazimine, is an oral medicine to be taken with meals. (medypharma.com)
  • Considerable re-pigmentation of vitiliginous skin occurred in 8 White female patients who were treated with clofazimine and exposed to natural sunlight. (journals.co.za)
  • We found that mutations in the MAB_2299c gene (which encodes a possible transcriptional regulatory protein), MAB_1483, and MAB_0540 are most commonly associated with clofazimine resistance. (cdc.gov)
  • The presence of other medical problems may affect the use of clofazimine. (drugs.com)
  • Clofazimine was approved for medical use in the United States in 1986. (wikipedia.org)
  • To buy Clofazimine online overnight delivery is very easy for everyone with some helping of our informational medical internet-service in our pharmacies-partners. (norxtabs.com)
  • Clofazimine is retained in the human body for a long time. (who.int)