CLOCK Proteins

Circadian Clocks

Circadian Rhythm Signaling Peptides and Proteins

Period Circadian Proteins

Biological Clocks

Circadian Rhythm

ARNTL Transcription Factors

Cryptochromes

Casein Kinase Iepsilon

Flavoproteins

Photoperiod

Suprachiasmatic Nucleus

E-Box Elements

Cyanobacteria

Casein Kinase Idelta

Synechococcus

Drosophila Proteins

Light

Neurospora

Basic Helix-Loop-Helix Transcription Factors

Nuclear Proteins

Photoreceptor Cells, Invertebrate

Transcription Factors

Feedback, Physiological

Drosophila

Trans-Activators

Cell Cycle Proteins

Gene Expression Regulation

Neurospora crassa

Insect Proteins

Mutation

Phosphorylation

Models, Biological

Bacterial Proteins

Motor Activity

Molecular Sequence Data

Drosophila melanogaster

Animals, Genetically Modified

Nuclear Receptor Subfamily 1, Group D, Member 1

Arabidopsis Proteins

Amino Acid Sequence

Arabidopsis

Transcription, Genetic

Fungal Proteins

RNA, Messenger

Protein Binding

Active Transport, Cell Nucleus

Dimerization

Mice, Knockout

Protein Structure, Tertiary

Protein Processing, Post-Translational

Darkness

Mutagenesis

Sequence Homology, Amino Acid

Promoter Regions, Genetic

Mice, Inbred C57BL

RNA Interference

Cell Nucleus

Time Factors

Neurons

Chronobiology Disorders

Gene Expression

Brain

Cell Line

Immunohistochemistry

Base Sequence

Gene Expression Regulation, Bacterial

Cyanobacterial clock proteins

Non-POU domain-containing octamer-binding protein

Chromosome 9 open reading frame 43

AutoDock

Ageing

Jrk

Bacterial archaeal holin family

Putative holin-2 family

Prophage Hp1 holin family

PhiU53 holin family

Lysin

P68 holin family

3-Hol family

LP holin family

BP holin family

A2 holin family

Treponema 4 TMS holin family

Hol-Tox family

T-A hol family

NP-holin family

ArpQ holin family

M1 hol family

Gene transfer agent-release holin family

T4 holin

Gp36 hol family

T1 holin family

L2 holin family

XanPHol family

BhlA holin family

Enterobacterial holin family

Securigera varia

Extraordinary Measures

Senescence

Promoter (genetics)

Medieval cuisine

Timeline of human evolution

WNT3A

Oxycodone

Postpartum psychosis

Snail (disambiguation)

Age and female fertility

Salmonidae

Culture Club

AP-1 transcription factor

DNA damage theory of aging

Gary Barnacle discography

Annonaceae

Nocturnin

Monotreme

Semaglutide

Sanju

Gliding motility

Paleogenetics

Epigenomics

Molecular anthropology

List of Ig Nobel Prize winners

Judy Liu

PF-4800567

Food-entrainable oscillator

Circadian clock proteins4

• Research on the mechanisms underlying circadian rhythmicity and the response of brain and body clocks to environmental and physiological challenges requires assessing levels of circadian clock proteins. (umassmed.edu)
• The goal of this project was to generate and characterize antibodies against several circadian clock proteins. (umassmed.edu)
• Our results identify antibodies against PER1, PER2, BMAL1 and CLOCK that are useful for assessing circadian clock proteins in the SCN by immunocytochemistry. (umassmed.edu)
• 16. SnapShot: circadian clock proteins. (nih.gov)

Genes14

• Just as a pocket watch requires a complex system of gears and springs to keep it ticking precisely, individual cells have a network of proteins and genes that maintain their own internal clock-a daily rhythm that, in humans, regulates metabolism, cell division and hormone production, as well as the wake-sleep cycle. (rockefeller.edu)
• In the fly, two of those genes-called period and timeless -produce proteins that fluctuate in a negative feedback loop that takes about 24 hours to complete. (rockefeller.edu)
• At night, two other genes, clock and cycle, stimulate production of Period and Timeless proteins, which begin to accumulate in the cell's cytoplasm. (rockefeller.edu)
• Wilcockson, DC , Zhang, L & Kyriacou, CP 2022, Methods for Delivery of dsRNAi Against Canonical Clock Genes and Immunocytodetection of Clock Proteins in Crustacea . (aber.ac.uk)
• Home News Role Identified for Brain Protein Regulated by Circadian Clock Genes in Clearing. (genengnews.com)
• Their work, reported in Science Translational Medicine , found that YKL-40 is both regulated by clock genes and involved in clearing away the potentially toxic build-up of Alzheimer's proteins in the brain. (genengnews.com)
• Musiek, whose work has long focused on the link between circadian rhythm and neurodegenerative diseases such as Alzheimer's, was conducting a screen for genes regulated by the circadian clock when the Chi3l1 gene caught his attention. (genengnews.com)
• The gene for YKL-40 came up as highly regulated by clock genes," Musiek said. (genengnews.com)
• New single cell live imaging approaches are revealing the importance of protein expression dynamics, particularly pulsatile and short-period oscillatory expression of the Hes genes, on the control of cell fate. (findaphd.com)
• 3. Circadian clock genes cause activation of the human PAI-1 gene promoter with 4G/5G allelic preference. (nih.gov)
• 4. A direct repeat of E-box-like elements is required for cell-autonomous circadian rhythm of clock genes. (nih.gov)
• The circadian clock controls the expression of nearly 50% of protein coding genes in mice and most likely in humans as well. (nih.gov)
• It involves various proteins, some of which serve as transcription factors for their own genes, particularly PER (encoded by the per gene) and TIM (encoded by the tim gene). (encyclopedia.com)
• Clock proteins combine with Arntl proteins to form heterodimeric transcription factors that are specific for E-BOX ELEMENTS and stimulate the transcription of several E-box genes that are involved in cyclical regulation. (nih.gov)

Mammalian circadian1

• Partch CL, Shields KF, Thompson CL, Selby CP, Sancar A. Posttranslational regulation of the mammalian circadian clock by cryptochrome and protein phosphatase 5. (proteopedia.org)

BMAL15

• Using human melanocytes and melanoma cells under synchronized clock conditions, we observed that the microphthalmia-associated transcription factor (MITF), a rate-limiting protein in melanin synthesis, is expressed rhythmically with 24-hr periodicity in the presence of circadian clock protein, BMAL1. (nih.gov)
• To investigate the localization and diurnal variation of clock proteins (BMAL1, PER2) and clock output protein (DBP) in the remnant kidney of 5/6 nephrectomy rats (STNx). (bvsalud.org)
• Kidneys were collected to detect the localization and expression rhythm of clock proteins (BMAL1, PER2 and DBP) every 4 h throughout the day by immunohistochemistry and Western blotting . (bvsalud.org)
• 19. Synergistic regulation of the mouse orphan nuclear receptor SHP gene promoter by CLOCK-BMAL1 and LRH-1. (nih.gov)
• Because many cellular functions including the cell cycle and cell division are, at least in part, controlled by the molecular clock components (CLOCK, BMAL1, CRYs, PERs), it has also been expected that appropriate timing of chemotherapy may increase the efficacy of chemotherapeutic drugs and ameliorate their side effect. (nih.gov)

Regulates3

• Musiek is senior author of the researchers' paper, which is titled, " Chi3l1 /YKL-40 is controlled by astrocyte circadian clock and regulates neuroinflammation and Alzheimer's disease pathogenesis . (genengnews.com)
• 20. CLOCK regulates circadian platelet activity. (nih.gov)
• This transcriptional activation also sets into motion a time-dependent feedback loop which in turn down-regulates the expression of clock proteins. (nih.gov)

Antibodies3

• Too often, however, it is difficult to acquire antibodies that specifically and reliably label these proteins. (umassmed.edu)
• by Gertrud U. Rey Antibodies are large proteins that are made by B cells of the adaptive immune system. (virology.ws)
• The light-based technique, called luciferase immunoprecipitation system (LIPS), showed high sensitivity and specificity to antibodies against the spike and nucleocapsid proteins of SARS-CoV-2. (nih.gov)

Synthesis4

• Though DNA repair, cell cycle, and apoptosis are clock controlled, the circadian mechanisms associated with melanin synthesis are not well understood. (nih.gov)
• We show that the cost of toxic protein misfolding is small compared to other costs associated with protein synthesis. (nih.gov)
• Today, we continue with the cell - the basic processes of DNA transcription, RNA translation, and protein synthesis. (coturnix.org)
• On episode #30 of the science show This Week in Microbiology, Vincent, Elio, and Michael review how a toxin from Burkholderia pseudomallei inhibits protein synthesis, and the role of the gut microbiome in modulating insulin resistance in mice lacking an innate immune sensor. (virology.ws)

Arntl1

• This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. (nih.gov)

Gene7

• CLOCK is an acronym for "Circadian Locomotor Output Cycles Kaput," because it is a central regulator of gene expression related to the body's circadian rhythm of sleeping and waking. (neurosciencenews.com)
• A recent study identified a possible deactivating mutation in the gene for a human jaw muscle protein (MYH16). (creation.com)
• Here we describe techniques for delivery of dsRNAi molecules to knock down clock gene transcripts in a small intertidal crustacean, Eurydice pulchra, as well as our method for immunodetection of clock proteins in the brain. (aber.ac.uk)
• 1. Identification of the circadian clock-regulated E-box element in the mouse plasminogen activator inhibitor-1 gene. (nih.gov)
• 2. Involvement of circadian clock gene Clock in diabetes-induced circadian augmentation of plasminogen activator inhibitor-1 (PAI-1) expression in the mouse heart. (nih.gov)
• 15. Role for the Clock gene in bipolar disorder. (nih.gov)
• The pattern of PER-, BMAL-, and aryl hydrocarbon receptor-induced P450 gene expression and BaP metabolism was similar to BaP-induced Cyp1A1 and Cyp1B1 and molecular clock gene expression in mouse mammary glands. (nih.gov)

Expression6

• Protein expression level is the dominant determinant of the clock rate in a number of organisms. (nih.gov)
• In particular they measured a notable decrease in the expression of RNA for CLOCK compared to controls. (neurosciencenews.com)
• Expression of other associated proteins in the pathway were also reduced when CLOCK was missing. (neurosciencenews.com)
• We examined mice and hamsters at peak and trough times of clock protein expression in the suprachiasmatic nucleus (SCN). (umassmed.edu)
• 9. Light-inducible and clock-controlled expression of MAP kinase phosphatase 1 in mouse central pacemaker neurons. (nih.gov)
• 11. Ketogenic diet disrupts the circadian clock and increases hypofibrinolytic risk by inducing expression of plasminogen activator inhibitor-1. (nih.gov)

PER11

• SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein. (proteopedia.org)

Reliably2

• But in a recent study in Nature Medicine , an NIH-funded research team was able to gauge a person's age quite reliably by analyzing a blood sample for levels of a few hundred proteins. (nih.gov)
• As further validation, the clock also reliably predicted the correct chronological age of four groups of people not in the study. (nih.gov)

Biological Clocks2

• Based on presentations by world-renowned investigators at the 72nd annual Cold Spring Harbor Symposium on Quantitative Biology, this volume reviews the latest advances in biological clocks and rhythms. (cshlpress.com)
• Biological clocks underlie many of the biorhythms seen in organisms (e.g. hibernation in animals). (encyclopedia.com)

Kinase1

• Her most recent work demonstrating that activation of CRH transcription requires the CREB coactivator, Transducer of Regulated CREB activity (TORC), regulated by the protein kinase, salt inducible kinase (SIK), uncovered a missing link in current knowledge of the regulation of CRH transcription. (nih.gov)

Cells8

• But now, a new report in this week's issue of Science turns the old model on its head: By providing a glimpse into living cells, Rockefeller University researchers have uncovered a previously undetected clock inside the circadian clock. (rockefeller.edu)
• The study provides evidence that excessive excitation of specific brain cells may be due to a lack of CLOCK in the region of the brain that produces the seizures. (neurosciencenews.com)
• One genetically "knocked out" CLOCK in excitatory neurons and the other knocked it out of inhibitory cells. (neurosciencenews.com)
• They found that the excitatory neurons lacking CLOCK were not inherently more excitable, but they received significantly less inhibitory current than similar cells in the same region in healthy controls. (neurosciencenews.com)
• Liu acknowledged that study does not explain why disruption of the CLOCK pathway reduces the inhibitory current within the cells after it arrives via their connections, or "synapses," with other neurons in their circuits. (neurosciencenews.com)
• Cells in nearly every human tissue and organ contain proteins that govern circadian rhythms. (nih.gov)
• After all, those proteins found circulating in the bloodstream come not just from blood cells but also from cells throughout the body. (nih.gov)
• Geldanamycin, an Hsp90 inhibitor, reduces the steady-state abundance of all polyalanine-expanded proteins in transfected cells. (nih.gov)

Regulation3

• While segmentation clock and wave front mechanisms have been elucidated to control the size and time of somite formation, regulation of the segmentation process that physically separates somites is not understood in detail. (frontiersin.org)
• 8. Role of angiotensin and the clock system in the circadian regulation of plasminogen activator inhibitor-1. (nih.gov)
• Basic helix-loop-helix (bHLH) domain-containing proteins that contain intrinsic HISTONE ACETYLTRANSFERASE activity and play important roles in CIRCADIAN RHYTHM regulation. (nih.gov)

Degradation1

• Thus, the difference between HOXA13 polyalanine expansion loss-of-function and HOXD13 polyalanine expansion dominant-negative effect is not the ability to aggregate wild-type group 13 paralogs but perhaps to variation in activities associated with refolding, aggregation or degradation of the proteins. (nih.gov)

Immunocytochemistry1

• To address this paradox we examined the cellular consequences of polyalanine expansions on HOXA13 protein using COS cell transfection and immunocytochemistry. (nih.gov)

Molecular clock2

• The nature of the protein molecular clock, the protein-specific rate of amino acid substitutions, is among the central questions of molecular evolution. (nih.gov)
• The purpose of this study was to define the impact of circadian rhythms on benzo-a-pyrene (BaP) metabolism in the mouse mammary gland and develop a circadian in vitro model for investigating changes in BaP metabolism resulting from cross-talk between the molecular clock and aryl hydrocarbon receptor. (nih.gov)

Body clocks1

• But the 50 subjects in the study whose brains had Alzheimer's-related proteins all had disrupted body clocks. (businessinsider.com)

Mice2

• The mice with loss of CLOCK in excitatory neurons displayed symptoms of epilepsy very similar to the human patients, including greater susceptibility to seizures, particularly arising out of sleep. (neurosciencenews.com)
• Similarly, genetically engineered mice with clock disruption do not exhibit spontaneous or radiation-induced cancers at higher incidence than wild-type controls. (nih.gov)

Disruption3

• Circadian rhythm disruption (i.e., misalignment of circadian rhythms), which results from the lack of synchrony between the master circadian clock located in the suprachiasmatic nuclei (SCN) and the environment (i.e., exposure to day light) or the master clock and the peripheral clocks, has been associated with increased risk of and unfavorable cancer outcomes. (cdc.gov)
• Test whether, and how, molecular and cellular processes, acute or chronic disruption of sleep, and/or circadian rhythms modulate accumulation and/or spreading of pathological protein aggregates. (nih.gov)
• Therefore, disruption of the circadian clock is presumed to have serious pathological effects including cancer. (nih.gov)

Affects4

• Although we cannot rule out the possibility that selection against misfolding toxicity significantly affects the protein clock in species other than E. coli, our results suggest that it is unlikely to be the dominant and universal factor determining the clock rate in all organisms. (nih.gov)
• Because the study directly implicates a specific protein pathway in a specific part of a patient's brain, Liu said a strategy for further research could be to deliver a drug that compensates for the lack of CLOCK, or perhaps a protein it affects, directly in that location. (neurosciencenews.com)
• This process, known as methylation, affects interactions between DNA and protein-making machinery. (nih.gov)
• We hope that a better understanding of how the circadian clock affects YKL-40 could lead to a new strategy for reducing amyloid in the brain. (genengnews.com)

Rhythm3

• Summary: A protein associated with circadian rhythm appears to play a significant role in some forms of epilepsy, researchers say. (neurosciencenews.com)
• Clock proteins showed diurnal rhythm in the kidney of the control. (bvsalud.org)
• But diurnal rhythm of clock proteins changed in the STNx rats . (bvsalud.org)

Endogenous1

• biological clock An endogenous, physiological mechanism, whose exact nature has not been determined, that keeps time independently of external events, enabling organisms to determine and to respond to daily, lunar, seasonal, and other periodicities. (encyclopedia.com)

Bind2

• They discovered that, rather than randomly colliding, the two proteins bind together in the cytoplasm almost immediately and create what Young and Meyer refer to as an "interval timer. (rockefeller.edu)
• This method, which does not require fractionation of the sample by gel electrophoresisis, is based on the property of proteins to readily bind to a plastic surface. (virology.ws)

Blog Around The C1

• Welcome to A Blog Around The Clock. (scienceblogs.com)

Aging3

• The researchers then used data from more than half of the participants to assemble a "proteomic clock" of aging. (nih.gov)
• However, because the effect of aging on the most important proteins of the clock is much stronger than the differences in gender, the proteomic clock still could accurately predict the ages in all people. (nih.gov)
• Overall, the findings show that protein substances in blood can serve as a useful measure of a person's chronological and biological age and - together with Wyss-Coray's earlier studies - that substances in blood may play an active role in the aging process. (nih.gov)

Generate2

• It has been suggested that highly expressed proteins evolve slowly in all species mainly to maintain robustness to translation errors that generate toxic misfolded proteins. (nih.gov)
• Positive feedback loops with substrate depletion can also generate oscillations, inspiring other circadian clock models. (nature.com)

Plaques3

• If your circadian clock is not quite right for years and years-you routinely suffer from disrupted sleep at night and napping during the day-the cumulative effect of chronic dysregulation could influence inflammatory pathways such that you accumulate more amyloid plaques," said Musiek. (genengnews.com)
• This isn't the first study to connect bad sleep with the buildup of proteins known as amyloid plaques, which can be indications of Alzheimer's and dementia. (businessinsider.com)
• They also analyzed their brains to look for Alzheimer's-related proteins and plaques. (businessinsider.com)

Tick1

• Some proteins did gradually tick up or down over time in an almost linear fashion. (nih.gov)

Aggregates4

• Determine processes interrupted by disordered sleep and circadian disruptions that lead to AD/ADRD-related pathologies such as accumulation of protein aggregates, synaptic loss, or dendritic pruning. (nih.gov)
• Assess how various patterns of neuronal activity and sleep architecture modulate accumulation and/or spreading of pathological protein aggregates. (nih.gov)
• HOXA13 polyalanine expansion proteins form cytoplasmic aggregates, and distribution between cytoplasmic aggregates or the nucleus is polyalanine tract size-dependent. (nih.gov)
• We also found that wild-type HOXA13 or HOXD13 proteins are sequestered in HOXA13 polyalanine expansion cytoplasmic aggregates. (nih.gov)

Drosophila2

• What Is There Left to Learn about the Drosophila Clock? (cshlpress.com)
• Studies in the fruit fly Drosophila have revealed the molecular basis of the biological clock, and similar mechanisms are thought to occur in other animals, including mammals. (encyclopedia.com)

Nucleus4

• Prior studies, which examined the placement of Period and Timeless during different stages of the cycle, seemed to indicate that the two proteins idle in a cell's cytoplasm until they bump into each other and then, bound together, enter the nucleus. (rockefeller.edu)
• Then, six hours after coming together, the complexes rapidly break apart and the proteins move into the nucleus singly, all of them within minutes of each other. (rockefeller.edu)
• The proteins pop apart and roll into the nucleus," Young says. (rockefeller.edu)
• The timing of each cycle is determined by the time required for transcription, export of messenger RNA to the cytoplasm, translation, and, crucially, the formation of PER-TIM dimers - the only form in which these two proteins can enter the nucleus. (encyclopedia.com)

Inhibitory2

• Further analysis including in tissues from more patients with other forms of epilepsy also showed that CLOCK RNA and protein were often significantly lacking in both in excitatory and inhibitory neurons in affected brain regions. (neurosciencenews.com)
• The D 2L R/5-HT 1A R inhibitory G-protein-coupled heteromer may function as a negative feedback regulator to suppress psychosocial stress. (jneurosci.org)

Specific protein1

• A more rapid method than Western blot analysis to detect a specific protein in a cell, tissue, organ, or body fluid is enzyme-linked immunosorbent assay, or ELISA. (virology.ws)

Spike1

• One recent study found that even disrupting someone's sleep for a night could lead to a spike in Alzheimer's-related proteins. (businessinsider.com)

Peripheral1

• 17. Peripheral circadian oscillators require CLOCK. (nih.gov)

Mechanisms1

• In addition, research addressing the mechanisms of pulsatility of glucocorticoid secretion recently demonstrated that each ACTH-induced secretory pulse is associated with induction of steroidogenic proteins transcription. (nih.gov)

Genetic2

• Researchers from two independent research teams have discovered how the mislocalization of a protein, known as TDP-43, alters the genetic instructions for UNC13A, providing a possible therapeutic target that could also have implications in treating amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and other forms of dementia. (nih.gov)
• Broadly speaking what I do is take proteins and use chemical and genetic approaches to change their sequence or modify their characteristics and then use a range of techniques to see what has happened. (scienceblogs.com)

Investigate1

• Here we investigate this hypothesis experimentally by comparing the growth rate of Escherichia coli expressing wild type and misfolding-prone variants of the LacZ protein. (nih.gov)

Interactions2

• The method makes it possible to gauge interactions between proteins by fluorescently tagging them and measuring how they react to different wavelengths of light. (rockefeller.edu)
• He notes that this precise timer shows how carefully orchestrated interactions between proteins really are. (rockefeller.edu)

Produce1

• The first step was to analyze the "transcriptome" of the tissues, or the various RNA transcribed from DNA to produce proteins. (neurosciencenews.com)

Neurons2

• In other words, excitatory neurons lacking CLOCK aren't as effectively restrained as they should be, potentially leading to a lower threshold for the onset of seizures, the researchers found. (neurosciencenews.com)
• Notably, D 2L R formed a heteromer with 5-HT 1A R in serotonergic neurons, thereby suppressing 5-HT 1A R-activated G-protein-activated inwardly rectifying potassium conductance in D 2L R-KO serotonergic neurons. (jneurosci.org)

Organisms1

• Among different types of biological oscillations, circadian oscillation is widely spread, as the internal clock of most organisms gets synchronized to the environmental day/night cycle changes. (nature.com)

Variation1

• Altered diurnal variation and localization of clock proteins in the remnant kidney of 5/6 nephrectomy rats. (bvsalud.org)

Molecules1

• In essence, these molecules together act as a microscopic clock timed to waxing and waning sunlight. (nih.gov)

Rhythms2

• Our daily rhythms are set by a master clock in the brain that is driven by the day and night cycle. (genengnews.com)
• A study recently published in the journal JAMA Neurology found that adults with healthy memories who had disrupted circadian rhythms - also known as sleep cycles - had protein buildups of a substance called amyloid plaque, which can serve as an early sign of Alzheimer's. (businessinsider.com)

Cell3

• But no one had ever thought to use it to follow proteins in a single cell for an extended period of time. (rockefeller.edu)
• No one had ever labeled the components to follow them over time, to see one clock as it ticks away in a single cell," Young says. (rockefeller.edu)
• Each cell also maintains its own internal clock, pegged to the master clock. (genengnews.com)

Mechanism3

• While the segmentation clock and wave front mechanism has been established to control the timing and space of somite segmentation, the cellular events that mediate the separation of somites are less understood. (frontiersin.org)
• The circadian system is an innate clock mechanism that governs biological processes on a near 24-hour cycle. (cdc.gov)
• biological clock The mechanism, presumed to exist within many animals and plants, that produces regular periodic changes in behaviour or physiology. (encyclopedia.com)

Humans3

• The protein appeared to have a mutation in all humans that they examined. (creation.com)
• However, chimpanzees, gorillas, orangutans and macaques all express the full-length protein, which is incorporated into Type II bundles, so the jaw muscle is comparatively larger in these animals than in humans (figure 1). (creation.com)
• However, in this case, the mRNA for the protein is transcribed and appropriately spliced, although the protein was undetectable in the humans examined. (creation.com)

Search1

• In search of additional clues in the new study, the Wyss-Coray team tracked how the protein composition of blood changes as people age. (nih.gov)

Metabolic2

• Even in the presence of metabolic fluctuations, the circadian clock functions as a precise biological timekeeper 20 . (nature.com)
• 5. Plasminogen activator inhibitor-1 and the circadian clock in metabolic disorders. (nih.gov)

Disorders1

• Specifically, how and which extracellular matrix proteins promote proliferation over differentiation, a key step in developing potential postnatal treatments for developmental ocular disorders. (findaphd.com)

Human1

• KC1E_HUMAN Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. (proteopedia.org)

Dysfunction1

• The aim of this NOSI is to advance basic and clinical research on the causes and consequences of sleep deficiency and circadian clock dysfunction in AD/ADRD, and the roles of sleep and the circadian clock as modifiers of the onset and progression of neurodegeneration. (nih.gov)