AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentGeographicals
ClioquinolHydroxyquinolinesMyelitisChloroquinolinols4-Hydroxyaminoquinoline-1-oxideChelating AgentsOxyquinolineNitroquinolinesZincScintillation CountingAnti-Infective Agents, LocalFluorometholoneAdrenal Cortex HormonesAdministration, TopicalSkin DiseasesPancreatic JuiceNew ZealandClobetasol
Clioquinol
A potentially neurotoxic 8-hydroxyquinoline derivative long used as a topical anti-infective, intestinal antiamebic, and vaginal trichomonacide. The oral preparation has been shown to cause subacute myelo-optic neuropathy and has been banned worldwide.
Hydroxyquinolines
The 8-hydroxy derivatives inhibit various enzymes and their halogenated derivatives, though neurotoxic, are used as topical anti-infective agents, among other uses.
Myelitis
Inflammation of the spinal cord. Relatively common etiologies include infections; AUTOIMMUNE DISEASES; SPINAL CORD; and ischemia (see also SPINAL CORD VASCULAR DISEASES). Clinical features generally include weakness, sensory loss, localized pain, incontinence, and other signs of autonomic dysfunction.
Chloroquinolinols
8-Hydroxyquinolinols chlorinated on the number 5 and/or 7 carbon atom(s). They are antibacterial, antiprotozoal, and antidiarrheal, especially in amebiasis, and have also been used as antiseborrheics. The compounds are mostly used topically, but have been used also as animal feed additives. They may cause optic and other neuropathies and are most frequently administered in combination with other agents.
4-Hydroxyaminoquinoline-1-oxide
A potent mutagen and carcinogen. It is a reduction product of 4-NITROQUINOLINE-1-OXIDE. It binds with nucleic acids and inactivates both bacteria and bacteriophage.
Chelating Agents
Chemicals that bind to and remove ions from solutions. Many chelating agents function through the formation of COORDINATION COMPLEXES with METALS.
Oxyquinoline
An antiseptic with mild fungistatic, bacteriostatic, anthelmintic, and amebicidal action. It is also used as a reagent and metal chelator, as a carrier for radio-indium for diagnostic purposes, and its halogenated derivatives are used in addition as topical anti-infective agents and oral antiamebics.
Nitroquinolines
Quinolines substituted in any position by one or more nitro groups.
Zinc
A metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.
Scintillation Counting
Detection and counting of scintillations produced in a fluorescent material by ionizing radiation.
Anti-Infective Agents, Local
Substances used on humans and other animals that destroy harmful microorganisms or inhibit their activity. They are distinguished from DISINFECTANTS, which are used on inanimate objects.
Fluorometholone
A glucocorticoid employed, usually as eye drops, in the treatment of allergic and inflammatory conditions of the eye. It has also been used topically in the treatment of various skin disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p732)
Adrenal Cortex Hormones
Administration, Topical
The application of drug preparations to the surfaces of the body, especially the skin (ADMINISTRATION, CUTANEOUS) or mucous membranes. This method of treatment is used to avoid systemic side effects when high doses are required at a localized area or as an alternative systemic administration route, to avoid hepatic processing for example.
Skin Diseases
Pancreatic Juice
The fluid containing digestive enzymes secreted by the pancreas in response to food in the duodenum.
New Zealand
A group of islands in the southwest Pacific. Its capital is Wellington. It was discovered by the Dutch explorer Abel Tasman in 1642 and circumnavigated by Cook in 1769. Colonized in 1840 by the New Zealand Company, it became a British crown colony in 1840 until 1907 when colonial status was terminated. New Zealand is a partly anglicized form of the original Dutch name Nieuw Zeeland, new sea land, possibly with reference to the Dutch province of Zeeland. (From Webster's New Geographical Dictionary, 1988, p842 & Room, Brewer's Dictionary of Names, 1992, p378)
Clobetasol
A derivative of PREDNISOLONE with high glucocorticoid activity and low mineralocorticoid activity. Absorbed through the skin faster than FLUOCINONIDE, it is used topically in treatment of PSORIASIS but may cause marked adrenocortical suppression.

Metal chelator decreases Alzheimer beta-amyloid plaques. (1/73)

Transgenic mice developing beta-amyloid (Abeta) plaques are advancing experimental treatment strategies for Alzheimer's disease. The metal chelator, clioquinol, is reported by Cherny et al. (2001) to reduce Abeta plaques, presumably by chelation of Abeta-associated zinc and copper. This and other recent Abeta-modulating treatment approaches are discussed.  (+info)

Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice. (2/73)

Inhibition of neocortical beta-amyloid (Abeta) accumulation may be essential in an effective therapeutic intervention for Alzheimer's disease (AD). Cu and Zn are enriched in Abeta deposits in AD, which are solubilized by Cu/Zn-selective chelators in vitro. Here we report a 49% decrease in brain Abeta deposition (-375 microg/g wet weight, p = 0.0001) in a blinded study of APP2576 transgenic mice treated orally for 9 weeks with clioquinol, an antibiotic and bioavailable Cu/Zn chelator. This was accompanied by a modest increase in soluble Abeta (1.45% of total cerebral Abeta); APP, synaptophysin, and GFAP levels were unaffected. General health and body weight parameters were significantly more stable in the treated animals. These results support targeting the interactions of Cu and Zn with Abeta as a novel therapy for the prevention and treatment of AD.  (+info)

An iron-responsive element type II in the 5'-untranslated region of the Alzheimer's amyloid precursor protein transcript. (3/73)

Iron-responsive elements (IREs) are the RNA stem loops that control cellular iron homeostasis by regulating ferritin translation and transferrin receptor mRNA stability. We mapped a novel iron-responsive element (IRE-Type II) within the 5'-untranslated region (5'-UTR) of the Alzheimer's amyloid precursor protein (APP) transcript (+51 to +94 from the 5'-cap site). The APP mRNA IRE is located immediately upstream of an interleukin-1 responsive acute box domain (+101 to +146). APP 5'-UTR conferred translation was selectively down-regulated in response to intracellular iron chelation using three separate reporter assays (chloramphenicol acetyltransferase, luciferase, and red fluorescent protein reflecting an inhibition of APP holoprotein translation in response to iron chelation. Iron influx reversed this inhibition. As an internal control to ensure specificity, a viral internal ribosome entry sequence was unresponsive to intracellular iron chelation with desferrioxamine. Using RNA mobility shift assays, the APP 5'-UTRs, encompassing the IRE, bind specifically to recombinant iron-regulatory proteins (IRP) and to IRP from neuroblastoma cell lysates. IRP binding to the APP 5'-UTR is reduced after treatment of cells with desferrioxamine and increased after interleukin-1 stimulation. IRP binding is abrogated when APP cRNA probe is mutated in the core IRE domain (Delta4 bases:Delta83AGAG86). Iron regulation of APP mRNA through the APP 5'-UTR points to a role for iron in the metabolism of APP and confirms that this RNA structure can be a target for the selection of small molecule drugs, such as desferrioxamine (Fe chelator) and clioquinol (Fe, Cu, and Zn chelator), which reduce Abeta peptide burden during Alzheimer's disease.  (+info)

Ironic fate: can a banned drug control metal heavies in neurodegenerative diseases? (4/73)

In this issue of Neuron, Kaur et al. demonstrate that iron chelation by ferritin transgene or the metal chelator clioquinol prevent oxidative damage and MPTP toxicity in mice. This raises the issue of specific iron chelators or clioquinol for control of oxidative damage in Parkinson's, Alzheimer's, and other neurodegenerative diseases, but not without safety concerns.  (+info)

Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: a novel therapy for Parkinson's disease. (5/73)

Studies on postmortem brains from Parkinson's patients reveal elevated iron in the substantia nigra (SN). Selective cell death in this brain region is associated with oxidative stress, which may be exacerbated by the presence of excess iron. Whether iron plays a causative role in cell death, however, is controversial. Here, we explore the effects of iron chelation via either transgenic expression of the iron binding protein ferritin or oral administration of the bioavailable metal chelator clioquinol (CQ) on susceptibility to the Parkinson's-inducing agent 1-methyl-4-phenyl-1,2,3,6-tetrapyridine (MPTP). Reduction in reactive iron by either genetic or pharmacological means was found to be well tolerated in animals in our studies and to result in protection against the toxin, suggesting that iron chelation may be an effective therapy for prevention and treatment of the disease.  (+info)

Subacute myelo-optic neuropathy and clioquinol. An epidemiological case-history for diagnosis. (6/73)

Between about 1955 and 1970, some 100,000 Japanese were diagnosed as having subacute myelooptic neuropathy (SMON), a new disease characterized by abdominal and neurological manifestations, the former nearly always preceding the latter. Circumstantial evidence obtained in 1969-70 suggested that SMON might have been caused by clioquinol (CQL), a gastrointestinal disinfectant, and led to the suspension of further sales of CQL in Japan. However, several inconsistencies for the CQL theory of SMON have now emerged; first, CQL had been widely used in Japan for nearly 20 years before SMON occurred. Secondly, the SMON epidemic began to subside several months before CQL sales were suspended. Thirdly, a large proportion of SMON patients--probably about one-third and possibly more--had not taken CQL within six months of the onset of the disease (the modal interval between first taking CQL and the onset of SMON being about three weeks, and more than 100 days in only 4% of SMON patients); of the remaining two-thirds or so, many had taken CQL as part of the treatment of the first (that is, abdominal) symptoms of SMON itself. Fourthly, there was no dose-response relationship. Finally, SMON rarely, if ever, occurred outside Japan. CQL could, however, have been involved in the causation of SMON as an optional enhancer of some other necessary cause; the history of post-war environmental pollution in Japan is compatible with this hypothesis. Over-readiness to accept postulated toxic effects of medicines and chemicals as proven is likely to do at least as much harm as good to individual and community health.  (+info)

Cu2+-induced modification of the kinetics of A beta(1-42) channels. (7/73)

We found that the amyloid beta peptide A beta(1-42) is capable of interacting with membrane and forming heterogeneous ion channels in the absence of any added Cu2+ or biological redox agents that have been reported to mediate A beta(1-42) toxicity. The A beta(1-42)-formed cation channel was inhibited by Cu2+ in cis solution ([Cu2+]cis) in a voltage- and concentration-dependent manner between 0 and 250 microM. The [Cu2+]cis-induced channel inhibition is fully reversible at low concentrations between 50 and 100 microM [Cu2+]cis and partially reversible at 250 microM [Cu2+]cis. The inhibitory effects of [Cu2+]cis between 50 and 250 microM on the channel could not be reversed with addition of Cu2+-chelating agent clioquinol (CQ) at concentrations between 64 and 384 microM applied to the cis chamber. The effects of 200-250 microM [Cu2+]cis on the burst and intraburst kinetic parameters were not fully reversible with either wash or 128 microM [CQ]cis. The kinetic analysis of the data indicate that Cu2+-induced inhibition was mediated via both desensitization and an open channel block mechanism and that Cu2+ binds to the histidine residues located at the mouth of the channel. It is proposed that the Cu2+-binding site of the A beta(1-42)-formed channels is modulated with Cu2+ in a similar way to those of channels formed with the prion protein fragment PrP(106-126), suggesting a possible common mechanism for Cu2+ modulation of A beta and PrP channel proteins linked to neurodegenerative diseases.  (+info)

Changes in intracellular calcium and glutathione in astrocytes as the primary mechanism of amyloid neurotoxicity. (8/73)

Although the accumulation of the neurotoxic peptide beta amyloid (betaA) in the CNS is a hallmark of Alzheimer's disease, the mechanism of betaA neurotoxicity remains controversial. In cultures of mixed neurons and astrocytes, we found that both the full-length peptide betaA (1-42) and the neurotoxic fragment (25-35) caused sporadic cytoplasmic calcium [intracellular calcium ([Ca2+]c)] signals in astrocytes that continued for hours, whereas adjacent neurons were completely unaffected. Nevertheless, after 24 hr, although astrocyte cell death was marginally increased, approximately 50% of the neurons had died. The [Ca2+]c signal was entirely dependent on Ca2+ influx and was blocked by zinc and by clioquinol, a heavy-metal chelator that is neuroprotective in models of Alzheimer's disease. Neuronal death was associated with Ca2+-dependent glutathione depletion in both astrocytes and neurons. Thus, astrocytes appear to be the primary target of betaA, whereas the neurotoxicity reflects the neuronal dependence on astrocytes for antioxidant support.  (+info)

Cell death process induced by hydrogen peroxide is accelerated by clioquinol in rat thymocytes - Tokushima University...
We examined the effect of clioquinol on the process of cell death induced by hydrogen peroxide (H2O2) using a flow cytometric technique with propidium iodide and annexin V-FITC in order to see if clioquinol augments the toxicity caused by oxidative stress. Clioquinol (100 nM) alone did not change the process of spontaneous cell death. However, the agent accelerated the process of cell death induced by 300 μM H2O2. Result indicates that clioquinol augments the cytotoxicity induced by H2O2. Therefore, the use of clioquinol may be inadequate for the treatment of some diseases related to oxidative stress ...
https://repo.lib.tokushima-u.ac.jp/en/111008
Causes of Toxic polyneuropathy -- Clioquinol - RightDiagnosis.comCauses of Toxic polyneuropathy -- Clioquinol - RightDiagnosis.com
Causes of Toxic polyneuropathy - Clioquinol including triggers, hidden medical causes of Toxic polyneuropathy - Clioquinol, risk factors, and what causes Toxic polyneuropathy - Clioquinol.
http://www.rightdiagnosis.com/t/toxic_polyneuropathy_clioquinol/causes.htm
clioquinol and hydrocortisone topical | PeaceHealthclioquinol and hydrocortisone topical | PeaceHealth
Clioquinol topical fights bacteria and prevents fungus from growing on your skin. Hydrocortisone is a topical steroid. It reduces the actions of chemicals in the body that cause inflammation. Clioquinol and hydrocortisone is a combination medicine used to treat skin infections caused by fungus (such as ringworm or jock...
https://www.peacehealth.org/medical-topics/content/multum/d03552a1.html
Toxic polyneuropathy -- Clioquinol Symptoms, Diagnosis, Treatments and Causes - RightDiagnosis.comToxic polyneuropathy -- Clioquinol Symptoms, Diagnosis, Treatments and Causes - RightDiagnosis.com
Toxic polyneuropathy - Clioquinol information including symptoms, diagnosis, misdiagnosis, treatment, causes, patient stories, videos, forums, prevention, and prognosis.
http://www.rightdiagnosis.com/t/toxic_polyneuropathy_clioquinol/intro.htm
Clioquinol/hydrocortisone/pramoxine topical Disease Interactions - Drugs.comClioquinol/hydrocortisone/pramoxine topical Disease Interactions - Drugs.com
Comprehensive disease interaction information for clioquinol/hydrocortisone/pramoxine topical. Includes Topical Corticosteroids - Diabetes.
https://www.drugs.com/disease-interactions/clioquinol-hydrocortisone-pramoxine-topical.html
Clioquinol / hydrocortisone topical have been looked over at the international conference together with itching, scaling,...
In some fact, many patients for taking drug restricted in some countries and develop mild itching, scaling, severe redness, soreness, or swelling of the skin that do not lead nearer to serious anaphylactic shock reaction. The Clioquinol / hydrocortisone topical gave me cry some itching, scaling, severe redness, soreness, or swelling of the skin car
http://ciclimoser.com/2020/02/14/fda-oks-itching-scaling-severe-redness-soreness-or-swelling-of-the-skin-drug-combo/
hydrocortisone + clioquinol | healthdirecthydrocortisone + clioquinol | healthdirect
More information is available on hydrocortisone + clioquinol including side effects, age restrictions, food interactions, whether the medicine is available at a government subsidised price on the pharmaceutical benefits scheme (PBS) as well as other useful information.
https://www.healthdirect.gov.au/medicines/medicinal-product/aht,23244/hydrocortisone-clioquinol
Human study: Clioquinol stops Alzheimers diseaseHuman study: Clioquinol stops Alzheimers disease
On Wed, 14 Jan 2004 11:36:14 -0800, RArmant ,av139 at lafn.org, wrote: ,The major research paper to this study can be found at: ,http://www.pranabio.com/research/major_published_papers.asp , Only the more severely affected patients in a limited pilot Phase 2 clinical trial benefitted from the treatment. This is a potentially very usefule and important development, but it is a far cry from the subject line of this post: Clioquinol STOPS Alzheimers disease! The unwary reader may easily get a very wrong impression ...
http://www.bio.net/bionet/mm/neur-sci/2004-January/056676.html
The capability to reprogram somatic cells to induced pluripotent stem cells (iPSCs) has revolutionized the field of...
The capability to reprogram somatic cells to induced pluripotent stem cells (iPSCs) has revolutionized the field of regenerative medicine. iPSC and ESC lines, between different passages of Clioquinol the same iPSC line, and even between Clioquinol different populations at a specific passage of the same iPSC line. Such variations potentially affect the properties of iPSCs and undermine their accountability in downstream applications. In this Perspective, we discuss the genetic and epigenetic variations in iPSCs and their causes, the implications of these variations in iPSC applications, and potential approaches to cope with these variations. Genetic variations in iPSCs An iPSC genome may harbor a wide range of variations, including aneuploidy, subchromosomal copy number variation (CNV), and single nucleotide variations (SNVs). These variations can be introduced into the iPSCs from different sources during iPSC generation and maintenance (Physique 1). First, genetic variations in iPSCs may ...
http://euroapicongres.org/?p=14
Clioquinol (Topical Route) Description and Brand Names - Mayo ClinicClioquinol (Topical Route) Description and Brand Names - Mayo Clinic
Portions of this document last updated: March 01, 2017. Copyright © 2018 Truven Health Analytics Inc. All rights reserved. Information is for End Users use only and may not be sold, redistributed or otherwise used for commercial purposes.. ...
https://www.mayoclinic.org/drugs-supplements/clioquinol-topical-route/description/drg-20062987
Betamethasone Clioquinol Cream | PrivateDoc®Betamethasone Clioquinol Cream | PrivateDoc®
A potent anti-inflammatory steroid cream with both antibacterial and antifungal properties. Used to treat skin conditions such as eczema, dermatitis, psoriasis and both bacterial and fungal infections secondary to these conditions.
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Moir, Robert, PhD | MassGeneral Institute for Neurodegenerative DiseaseMoir, Robert, PhD | MassGeneral Institute for Neurodegenerative Disease
Robert Moirs research focuses on the biochemical and cellular mechanisms of neurodegeneration in Alzheimers disease (AD) and aging. His work has uncovered new therapeutic targets aimed at preventing the accumulation of beta-amyloid (Aβ), the primary neurotoxic agent in AD. Moir was the first to identify the low-density lipoprotein receptor protein (LRP) as the mediator of an important early step in Aβ production in the brain. Today, LRP-mediated Aβ clearance pathways are increasingly recognized as major targets for therapeutic intervention. His work revealed the importance of metals in the pathological aggregation of Aβ, leading directly to the investigation of the copper and zinc chelator clioquinol in clinical trials for AD. Moir has also helped establish Aβs role in the formation of eye lens cataracts in AD patients, which could lead to better diagnosis of the disease. His studies on the immune response to amyloid have revealed potential abnormalities in protective Aβ-reactive ...
https://mghmind.org/faculty/moir-robert-phd
FDA advisory committee: More data, consistent testing needed for metal-containing implantsFDA advisory committee: More data, consistent testing needed for metal-containing implants
The Immunology Devices Panel of the Medical Devices Advisory Committee recently met to provide advice and recommendations to the FDA about immunological responses to metal-containing products regulated as medical devices, including metal-containing implants and dental amalgam.“Overall, the panel feels that successful outcomes of procedures where devices are implanted in the body are
https://www.healio.com/orthopedics/business-of-orthopedics/news/online/%7Bce8e0226-a7c0-4514-8963-8bfc4141775d%7D/fda-advisory-committee-more-data-consistent-testing-needed-for-metal-containing-implants
Provate-C Oint 15gProvate-C Oint 15g
Product Name: Provate-C Oint 15g Form: Ointment Packsize: 15g Manufcturer: Saffron Pharmaceutical Generic Category: CORTICOSTEROID Ingredients: Betamethasone Dipropionate,Clioquinol
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Covid-19 natural remedies - Where is the evidence? - Autoimmune NutritionCovid-19 natural remedies - Where is the evidence? - Autoimmune Nutrition
Melatonin is a regulator of the immune system, and has been investigated as a treatment for Covid-19. Levels of melatonin decrease with age. If youre high risk for infection, it wouldnt hurt to take a moderate dose at bedtime. Hydrochloroquine probably works by allowing zinc to cross cell membranes (a zinc ionophore), allowing it to get inside of cells where they block viral RNA replication. It might also interfere with the virus binding to ACE receptors. Quercetin is a bioflavanoid that also is a zinc ionophore. Vitamin C isnt an exotic supplement, but rather an essential part of the innate immune system which we need for proper immune system and connective tissue health, and should be a part of everyones supplement regimen. Vitamin C has a long history of use for viral infections. Be cautious using very large doses during viral pneumonia. Extremely high doses are dangerous for certain people, so check with your healthcare provider.. Herbs: Licorice is an adrenal and liver tonic, which Ive ...
https://nutrition101.org/2020/04/07/covid-19-natural-remedies-where-is-the-evidence/
Celeston Valerat med Chinoform (Betamethasone Valerate; Clioquinol) Schering-PloughCeleston Valerat med Chinoform (Betamethasone Valerate; Clioquinol) Schering-Plough
Celeston Valerat med Chinoform information about active ingredients, pharmaceutical forms and doses by Schering-Plough, Celeston Valerat med Chinoform indications, usages and related health products lists
http://drugs-about.com/drugs-c/celeston-valerat-chinoform.html
Nitroxoline - WikipediaNitroxoline - Wikipedia
Nitroxoline is an antibiotic that has been in use in Europe for about fifty years, and has proven to be very effective at combating biofilm infections. Nitroxoline was shown to cause a decrease in the biofilm density of P. aeruginosa infections, which would allow access to the infection by the immune system in vivo. It was shown that nitroxoline functions by chelating Fe2+ and Zn2+ ions from the biofilm matrix; when Fe2+ and Zn2+ were reintroduced into the system, biofilm formation was reconstituted. The activity of biofilm degradation is comparable to EDTA, but has a history of human use in clinical settings and therefore has a precedent with which to allow its use against slimy biofilm infections. The chelating activities of nitroxoline have also been used in an anticancer setting. Nitroxoline has been shown to be more cytotoxic to HL60, DHL-4, Panc-1, and A2780 cells lines than clioquinol and other 8-hydroxyquinoline derivatives. It also demonstrated an increase in reactive oxygen species ...
https://en.wikipedia.org/wiki/Nitroxoline
Plus itPlus it
Purpose: Glioblastoma is one of the most lethal cancers in humans, and with existing therapy, survival remains at 14.6 months. Current barriers to successful treatment include their infiltrative behavior, extensive tumor heterogeneity, and the presence of a stem-like population of cells, termed brain tumor-initiating cells (BTICs) that confer resistance to conventional therapies. Experimental Design: To develop therapeutic strategies that target BTICs we focused on a repurposing approach that explored already-marketed (clinically-approved) drugs for therapeutic potential against patient-derived BTICs that encompass the genetic and phenotypic heterogeneity of glioblastoma observed clinically. Results: Using a high-throughput in vitro drug screen we found that montelukast, clioquinol and disulfiram (DSF) were cytotoxic against a large panel of patient-derived BTICs. Of these compounds, disulfiram, an off-patent drug previously used to treat alcoholism, in the presence of a copper supplement, ...
http://clincancerres.aacrjournals.org/content/early/2016/03/22/1078-0432.CCR-15-1798
ATC code D09 - WikipediaATC code D09 - Wikipedia
ATC code D09 Medicated dressings is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the WHO for the classification of drugs and other medical products. Subgroup D09 is part of the anatomical group D Dermatologicals. Codes for veterinary use (ATCvet codes) can be created by placing the letter Q in front of the human ATC code: for example, QD09. National issues of the ATC classification may include additional codes not present in this list, which follows the WHO version. D09AA01 Framycetin D09AA02 Fusidic acid D09AA03 Nitrofural D09AA04 Phenylmercuric nitrate D09AA05 Benzododecinium D09AA06 Triclosan D09AA07 Cetylpyridinium D09AA08 Aluminium chlorohydrate D09AA09 Povidone-iodine D09AA10 Clioquinol D09AA11 Benzalkonium D09AA12 Chlorhexidine D09AA13 Iodoform D09AB01 Zinc bandage without supplements D09AB02 Zinc bandage with supplements ATC/DDD Index 2018: code D09. WHO Collaborating Centre for Drug Statistics ...
https://en.wikipedia.org/wiki/ATC_code_D09
Betnovate c 30g - Betamethasone - SafeHealthsBetnovate c 30g - Betamethasone - SafeHealths
Betnovate c 30g. Available Betnovate c 30g at SafeHealths.com site. Betnovate c 30g - Betnovate C 30g cream ( Betamethasone 0.10% / Clioquinol 3% ) - The betnovate c 30g is a generic cream which is a treatment for allergy symptoms, which cur
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Patent US7400043 - Semiconductor constructions - Google PatentsPatent US7400043 - Semiconductor constructions - Google Patents
The invention includes a method of forming a metal-containing film over a surface of a semiconductor substrate. The surface is exposed to a supercritical fluid. The supercritical fluid has H2, at least one H2-activating catalyst, and at least one metal-containing precursor dispersed therein. A metal-containing film is formed across the surface of the semiconductor substrate from metal of the at least one metal-containing precursor. The invention also includes semiconductor constructions having metal-containing layers which include one or more of copper, cobalt, gold and nickel in combination with one or more of palladium, platinum, iridium, rhodium and ruthenium.
http://www.google.com/patents/US7400043?dq=6519629
Wiley: Macromolecules Containing Metal and Metal-Like Elements, Volume 7: Nanoscale Interactions of Metal-Containing Polymers -...Wiley: Macromolecules Containing Metal and Metal-Like Elements, Volume 7: Nanoscale Interactions of Metal-Containing Polymers -...
VII. Total Energetic Requirements to Induce the Glass Transition via Consideration of the First-Shell Coordination Sphere in Transition Metal and Lanthanide Complexes. VIII. Summary. IX. Acknowledgments. X. References. 2. Metal Oxide Clusters as Building Blocks for Inorganic-Organic Hybrid Polymers (Ulrich Schubert). I. Introduction. II. Synthesis of Organically Modified Transition Metal Oxide Clusters. III. Synthesis and Structural Characterization of the Cluster-Reinforced Polymers. IV. Properties of the Cluster-Based Hybrid Polymers. V. Summary. VI. Acknowledgments. VII. References. 3. Metal-Containing Polydyes (Charles E. Carraher). I. Introduction. II. Group IVB-Containing Polydyes. III. Ruthenium-Containing Polydyes. IV. Hematoporphyrin-Containing Polydyes. V. Summary/VI. References. 4. Metallopolymer Nanocomposite-Macromulecular Metallocomplexes as Precursors for Polymers, Polymer Inorganics, and Bionanocomposites (A. D. Po,ogailo). I. Introduction. II. General Characteristics, ...
http://www.wiley.com/WileyCDA/WileyTitle/productCd-0471773255.html
NAVER Academic | Oxygen permeability of transition metal-containing La(Sr,Pr)Ga(Mg)O|sub|3-δ|/sub| ceramic membranesNAVER Academic | Oxygen permeability of transition metal-containing La(Sr,Pr)Ga(Mg)O|sub|3-δ|/sub| ceramic membranes
Acceptor-type doping of perovskite-type La1-xSrxGa0.80-yMgyM0.20O3-δ (x = 0-0.20, y = 0.15-0.20, M = Fe, Co, Ni) leads to significant enhancement of ionic conductivity and oxygen permeability due to increasing oxygen vacancy concentration. The increase in strontium and magnesium content is accompanied, however, with increasing role of surface exchange kinetics as permeation-limiting factor. At temperatures below 1223 K, the oxygen permeation fluxes through La(Sr)Ga(Mg,M)O3-δ membranes with thickness less than 1.5 mm are predominantly limited by the exchange rates at membrane surface. The oxygen transport in transition metal-containing La(Sr)Ga(Mg)O3-δ ceramics increase in the sequence Co | Fe | Ni. The ionic conduction in these phases is, however, lower than that in the parent compounds, La1-xSrxGa1-yMgyO3-δ. The highest level of oxygen permeation, comparable to that of La(Sr)Fe(Co)O3- and La2NiO4-based phases, is observed for La0.90Sr0.10Ga0.65Mg0.15Ni0.20O3-δ membranes. The average thermal
http://academic.naver.com/article.naver?doc_id=81411112
Buy Pyridoxine HCl (Vitamin B6) SupplementBuy Pyridoxine HCl (Vitamin B6) Supplement
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Vitamin B6 (as Pyridoxine HCl) | Natural Herba KingsVitamin B6 (as Pyridoxine HCl) | Natural Herba Kings
This website uses cookies to improve your experience while you navigate through the website. Out of these cookies, the cookies that are categorized as necessary are stored on your browser as they are essential for the working of basic functionalities of the website. We also use third-party cookies that help us analyze and understand how you use this website. These cookies will be stored in your browser only with your consent. You also have the option to opt-out of these cookies. But opting out of some of these cookies may have an effect on your browsing experience ...
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Researcher Builds Life-Like Cells Made of Metal - SlashdotResearcher Builds Life-Like Cells Made of Metal - Slashdot
Sven-Erik writes Could living things that evolved from metals be clunking about somewhere in the universe? In a lab in Glasgow, UK, one man is intent on proving that metal-based life is possible. He has managed to build cell-like bubbles from giant metal-containing molecules and has given them some...
https://science.slashdot.org/story/11/09/15/020200/Researcher-Builds-Life-Like-Cells-Made-of-Metal/funny-comments
Patent US7378482 - Compositions having improved bath life - Google PatentsPatent US7378482 - Compositions having improved bath life - Google Patents
A composition comprising (A) at least one compound having at least one aliphatic unsaturation; (B) at least one organohydrogensilicon compound containing at least one silicon-bonded hydrogen atom per molecule and (C) a platinum group metal-containing catalyst.
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Globally, more antimicrobials are used in food-producing animals than in humans, and the extensive use of medically important human antimicrobials poses a significant public health threat in the face of rising antimicrobial resistance (AMR). The development of novel ionophores, a class of antimicrobials used exclusively in animals, holds promise as a strategy to replace or reduce essential human antimicrobials in veterinary practice. PBT2 is a zinc ionophore with recently demonstrated antibacterial activity against several Gram-positive pathogens, although the underlying mechanism of action is unknown. Here, we investigated the bactericidal mechanism of PBT2 in the bovine mastitis-causing pathogen, Streptococcus uberis In this work, we show that PBT2 functions as a Zn2+/H+ ionophore, exchanging extracellular zinc for intracellular protons in an electroneutral process that leads to cellular zinc accumulation. Zinc accumulation occurs concomitantly with manganese depletion and the production of ...
https://pesquisa.bvsalud.org/portal/?lang=es&q=au:%22McDevitt,%20Christopher%20A%22
The Adsorption-Flocculation Method Using Bentonite for Treatment of Heavy Metal-Containing Wastewater--《RESEARCH OF...The Adsorption-Flocculation Method Using Bentonite for Treatment of Heavy Metal-Containing Wastewater--《RESEARCH OF...
The adsorption of Pb￣(2+), Cd￣(2+)and Cr￣(3+)ions respectively on the raw be ntonite and theconditions of flocculation of bentonite are studied in this paper.Combining the adsorption andflocculation,a new technology for treating wastewater is thus presented.When 0.04%of ben-tonite and 0.006%of PAC are added,93%of Pb￣(2+) iOn can be removed from the low concentra-tion wastewater.
http://en.cnki.com.cn/Article_en/CJFDTOTAL-HJKX401.009.htm
7-Hydroxyquinoline, TMS | C12H15NOSi - PubChem7-Hydroxyquinoline, TMS | C12H15NOSi - PubChem
7-Hydroxyquinoline, TMS | C12H15NOSi | CID 530132 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
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8-Hydroxyquinolines: a review of their metal chelating properties and medicinal applications. - PubMed - NCBI8-Hydroxyquinolines: a review of their metal chelating properties and medicinal applications. - PubMed - NCBI
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
https://www.ncbi.nlm.nih.gov/pubmed/24115839?dopt=Abstract
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The proteasome is clinically validated as a target for cancer therapeutics. However, proteasome-inhibitory agents that are cancer selective have yet to be developed. In this study, we report the identification of a safe and effective proteasome inhibitor with selective anticancer properties. We screened a chemical library constructed using a hybrid approach that incorporated a 4-piperazinylquinoline scaffold and a sulfonyl phamarcophore. From this library, we identified 7-chloro-4-(4-(2,4-dinitrophenylsulfonyl)piperazin-1-yl)quinoline (VR23) as a small molecule that potently inhibited the activities of trypsin-like proteasomes (IC50 = 1 nmol/L), chymotrypsin-like proteasomes (IC50 = 50-100 nmol/L), and caspase-like proteasomes (IC50 = 3 μmol/L). Data from molecular docking and substrate competition assays established that the primary molecular target of VR23 was β2 of the 20S proteasome catalytic subunit. Notably, VR23 was structurally distinct from other known proteasome inhibitors and ...
http://cancerres.aacrjournals.org/content/early/2015/09/17/0008-5472.CAN-14-3370
Self-assembled Ni nanoclusters in a diamond-like carbon matrix on Environmental XPRTSelf-assembled Ni nanoclusters in a diamond-like carbon matrix on Environmental XPRT
Article Self-assembled Ni nanoclusters in a diamond-like carbon matrix. Trace amounts (∼5 at%) of metal-containing diamond-like carbon films (DLC) have been deposited using a Off Plane Double Bend Filtered Cathodic Vacuum Arc (OPDB-FCVA) system. The ...
https://www.environmental-expert.com/articles/self-assembled-ni-nanoclusters-in-a-diamond-like-carbon-matrix-435754
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Method for treating wood with a metal-containing treating agent and wood treated thereby - Patent # 6541038 - PatentGenius
A method for treating wood, characterized by impregnating wood with a metal-containing treating agent containing lignin and/or lignin derivatives and a metal, a metal compound, and/or a metal ion and oxidizing and/or macromolecularizing of the lignin and/or lignin derivatives in the wood to fix the metal component in the wood, and wood and woody materials obtained by the treating method. According to the method of the present invention, while effectively utilizing lignins, lignosulfonic acids, or lignosulfonic acid salts, leaching of the metal component can be suppressed to a low level to thereby retain the effects due to the incorporation of the metal components for a prolonged period.
http://www.patentgenius.com/patent/6541038.html
Impact of copper and iron binding properties on the anticancer activity of 8-hydroxyquinoline derived Mannich bases<...
TY - JOUR. T1 - Impact of copper and iron binding properties on the anticancer activity of 8-hydroxyquinoline derived Mannich bases. AU - Pape, Veronika F.S.. AU - May, Nóra V.. AU - Gál, G. Tamás. AU - Szatmári, I.. AU - Szeri, Flóra. AU - Fülöp, F.. AU - Szakács, G.. AU - Enyedy, E.. PY - 2018/1/1. Y1 - 2018/1/1. N2 - The anticancer activity of 8-hydroxyquinolines relies on complex formation with redox active copper and iron ions. Here we employ UV-visible spectrophotometry and EPR spectroscopy to compare proton dissociation and complex formation processes of the reference compound 8-hydroxyquinoline (Q-1) and three related Mannich bases to reveal possible correlations with biological activity. The studied derivatives harbor a CH2-N moiety at position 7 linked to morpholine (Q-2), piperidine (Q-3), and chlorine and fluorobenzylamino (Q-4) substituents. Solid phase structures of Q-3, Q-4·HCl·H2O, [(Cu(HQ-2)2)2]·(CH3OH)2·Cl4·(H2O)2, [Cu(Q-3)2]·Cl2 and ...
https://hungary.pure.elsevier.com/en/publications/impact-of-copper-and-iron-binding-properties-on-the-anticancer-ac
中国科学院上海有机化学研究所机构知识库(SIOC OpenIR): Synthesis and luminescent properties of Zn complex based on 8-hydroxyquinoline group...
The use of a novel 2-substituted-8-hydroxyquinoline ligand (E)-2-{2-[3,5-bis(trifluoromethyl)phenyl] ethenyl}-8-hydroxyquinoline(4, BFHQ) characterized by EIMS, H-1 NMR spectroscopy, elemental analysis, and FTIR spectroscopy enabled the isolation of a trimeric Zn(II) complex with the formula Zn-3(BFHQ)(6) (5, Scheme 1). X-ray structural analysis shows that 5 exhibits a trinuclear core, which is bridged by four 8-hydroxyquinoline rings. The trinuclear core is surrounded by three pairs of BFHQ ligands with offset pi-pi stacking, showing propeller-like molecular structure. The aggregation behavior of Zn(AcO)(2) and the ligand 4 in solution was investigated by UV-vis. The luminescence properties of compound 5 were investigated by UV-vis and fluorescence spectra at room temperature. The experimental results show that the complex 5 emits yellow luminescence at 553 nm (lambda(em, max)) in DMSO solution and at 610 nm (lambda(em, max)) in solid state. The thermogravimetric analysis was carried out to ...
http://ir.sioc.ac.cn/handle/331003/14474
Investigation on the pharmacological profile of antimony(III) complexes with hydroxyquinoline derivatives: anti-trypanosomal...Investigation on the pharmacological profile of antimony(III) complexes with hydroxyquinoline derivatives: anti-trypanosomal...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
https://www.ncbi.nlm.nih.gov/pubmed/21221718?dopt=Abstract
Cooperative assembly of Zn cross-linked artificial tripeptides with pendant hydroxyquinoline ligands<...
TY - JOUR. T1 - Cooperative assembly of Zn cross-linked artificial tripeptides with pendant hydroxyquinoline ligands. AU - Zhang, Meng. AU - Gallagher, Joy A.. AU - Coppock, Matthew B.. AU - Pantzar, Lisa M.. AU - Williams, Mary Elizabeth. PY - 2012/11/5. Y1 - 2012/11/5. N2 - An artificial peptide with three pendant hydroxyquinoline (hq) ligands on a palindromic backbone was designed and used to form multimetallic assemblies. Reaction of the tripeptide with zinc acetate led to a highly fluorescent tripeptide duplex with three Zn(II) coordinative cross-links. The binding process was monitored using spectrophotometric absorbance and emission titrations; NMR spectroscopy and mass spectrometry confirmed the identity and stoichiometry of the product structure. Titrations monitoring duplex formation of the zinc-tripeptide structure had a sigmoidal shape, equilibrium constant larger than the monomeric analogue, and a Hill coefficient ,1, all of which indicate positive cooperativity. Photophysical ...
https://pennstate.pure.elsevier.com/en/publications/cooperative-assembly-of-zn-cross-linked-artificial-tripeptides-wi
Chloroquine & Hydroxychloroquine: supporting chemo effectiveness and more - Mihaela Catalina Stanciu Foundation for LifeChloroquine & Hydroxychloroquine: supporting chemo effectiveness and more - Mihaela Catalina Stanciu Foundation for Life
Preparation & Administration. Hydroxychloroquine comes in 200 mg tablets and is taken orally. The dose provided will be based upon a calculation of 6.5 mg/kg (subjects weight), which is the dose range commonly used to treat rheumatoid arthritis and lupus. Dosages will be rounded to the nearest 100 mg. Taken orally once a day. Administration during or after meals. (6.5 mg/kg will lead to about 400mg/day for most people.). Some clinical trials are increasing the daily dose up to 1000mg but I woudl not go that high. The highest I would go would probably be 600mg/day.. Adding Zinc may help: We report that chloroquine is a zinc ionophore, which targets zinc to the lysosomes, and that the combination of zinc and chloroquine enhances their cytotoxicity and induces apoptosis in a human cancer cell model system Ref.. Note: hydroxycloroquine € has a long half-life (32€56 days) in blood and a large volume of distribution (Ref). In other words, the max time required to be totally out of the blood may ...
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Wikipedia:Manual of Style/Chemistry - Photos and All Basic Informations
Article types[edit] Compounds[edit] Main page: Wikipedia:Manual of Style/Chemistry/Chemicals All articles on chemicals, real or hypothetical, should have a Chembox. Formulae should be readily available, variables like n, x, or y are permissible for substances of variable composition such as polymers. For compounds of defined composition, the molar masses should be available as well. The article should cover these aspects as appropriate: Sectioning[edit] Introductory paragraph (WP:lede) Properties (optional), the physical appearance of the material (at STP) Often this content is included in the lede. Unless notable, properties listed in the ChemBox are not repeated. Occurrence. Usually occurrence refers natural products, compounds or ions that exist naturally. Structure. The structures of many organic compounds are obvious, but inorganic and metal-containing compounds often adopt nonintuitive structures. When possible, their structures should be described, ideally based on crystallographic or ...
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Microwave-enhanced Friedländer synthesis for the rapid assembly of halogenated quinolines with antibacterial and biofilm...Microwave-enhanced Friedländer synthesis for the rapid assembly of halogenated quinolines with antibacterial and biofilm...
Herein, we disclose the development of a catalyst- and protecting-group-free microwave-enhanced Friedländer synthesis which permits the single-step, convergent assembly of diverse 8-hydroxyquinolines with greatly improved reaction yields over traditional oil bath heating (increased from 34% to 72%). This rap 2017 Hot Articles in MedChemComm New Talent: Americas
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TR 112 : Refined Approaches for Risk Assessment of PBT/vPvB Chemicals , October 2011 ISSN-0773-8072-112 (print) ISSN-2079-1526-112 (online) D-2011-3001-218 Summary Building upon a […]. ...
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IonophoreIonophore
Clioquinol and PBT2 are 8-hydroxyquinoline derivatives.[citation needed] Clioquinol has antiprotozoal and topical antifungal ... Clioquinol and PBT2 are currently being studied for neurodegenerative diseases, such as Alzheimer's disease, Huntington's ...
https://en.wikipedia.org/wiki/Ionophore
8-Hydroxyquinoline8-Hydroxyquinoline
Clioquinol, an antifungal drug and antiprotozoal drug. PBT2 QUPIC Ionophore Trace metal detection test Albert, A.; Phillips, J ...
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Subacute myelo-optic neuropathySubacute myelo-optic neuropathy
Clioquinol was marketed as a prophylaxis to tourist diarrhoea. Dr. Olle Hansson was in the front line, fighting for a ban of ... On August 3, 1978, the Tokyo District Court ruled that the cause of SMON is Clioquinol. Its manufacturer, Ciba-Geigy, has ... and Clioquinol: Nationwide Survey", The Lancet, V301, I7796, January 27, 1973, pp. 171-173 Reisaku Kono, "The S.M.O.N. Virus ... clioquinol. Doctors in many countries boycotted Ciba-Geigy for many years. Not until 1985 was the pharmaceutical withdrawn. Dr ...
https://en.wikipedia.org/wiki/Subacute_myelo-optic_neuropathy
AntifungalAntifungal
Clioquinol Coal tar Copper(II) sulfate Crystal violet - a triarylmethane dye. It has antibacterial, antifungal, and ...
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Copper in biologyCopper in biology
Daniel, Kenyon G; Chen, Di; Orlu, Shirley; Cui, Qiuzhi; Miller, Fred R; Dou, Q Ping (2005). "Clioquinol and pyrrolidine ...
https://en.wikipedia.org/wiki/Copper_in_biology
NitroxolineNitroxoline
... has been shown to be more cytotoxic to HL60, DHL-4, PANC-1, and A2780 [zh] cells lines than clioquinol and other 8- ... Because the zinc chelating action of clioquinol has been associated with subacute myelo-optic neuropathy, the use of ... is more a potent anti-cancer agent than clioquinol (5-chloro-7-iodo-8-quinoline)". Cancer Lett. 312 (1): 11-17. doi:10.1016/j. ...
https://en.wikipedia.org/wiki/Nitroxoline
Flumetasone pivalateFlumetasone pivalate
... study of novel green UV-spectrophotometric platforms for simultaneous rapid analysis of flumethasone pivalate and clioquinol in ...
https://en.wikipedia.org/wiki/Flumetasone_pivalate
BlastocystosisBlastocystosis
Clioquinol (Entero-vioform) was noted as successful in treatment of Blastocystis infection but removed from the market ...
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Transient global amnesiaTransient global amnesia
Marijuana intoxication, Halogenated hydroxyquinolines such as Clioquinol, PDE inhibitors such as sildenafil, Digitalis and ...
https://en.wikipedia.org/wiki/Transient_global_amnesia
LeprosyLeprosy
Topical ketanserin seems to have a better effect on ulcer healing than clioquinol cream or zinc paste, but the evidence for ...
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PBT2PBT2
It is a second-generation 8-hydroxyquinoline analog intended to be a successor to clioquinol and a potential treatment of ...
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FlumetasoneFlumetasone
It is available in combination with clioquinol, under the trade name Locacorten-Vioform (in some countries Locorten-Vioform), ...
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... may refer to: Cortin, a synonym for corticosteroid Cortin, a trade name for the antifungal drug clioquinol This ...
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Rudolph E. TanziRudolph E. Tanzi
2001: Showed that AD pathology in transgenic mice could be ameliorated by a zinc-copper chelator, clioquinol (PBT1) 2003: ... Clioquinol (PBT1) successful in a phase 2 AD clinical trial. 2003: Discovered that apoptosis and caspase activation induces ...
https://en.wikipedia.org/wiki/Rudolph_E._Tanzi
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... may stand for: Subacute myelo-optic neuropathy, an epidemic in Japan caused by clioquinol SMON, a set of MIB extensions ...
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... combinations G01AB01 Acetarsol G01AC01 Diiodohydroxyquinoline G01AC02 Clioquinol G01AC03 Chlorquinaldol G01AC05 Dequalinium ...
https://en.wikipedia.org/wiki/ATC_code_G01
List of MeSH codes (D03)List of MeSH codes (D03)
... clioquinol MeSH D03.438.810.350.625.420 - iodoquinol MeSH D03.438.810.350.700 - procaterol MeSH D03.438.810.410 - mefloquine ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D03)
ATC code P01ATC code P01
P01AA01 Broxyquinoline P01AA02 Clioquinol P01AA04 Chlorquinaldol P01AA05 Tilbroquinol P01AA30 Tilbroquinol and tiliquinol ... P01AA52 Clioquinol, combinations P01AB01 Metronidazole P01AB02 Tinidazole P01AB03 Ornidazole P01AB04 Azanidazole P01AB05 ...
https://en.wikipedia.org/wiki/ATC_code_P01
Standard for the Uniform Scheduling of Medicines and PoisonsStandard for the Uniform Scheduling of Medicines and Poisons
Clioquinol and other halogenated derivatives of oxyquinoline for human internal use except or when being used solely for ...
https://en.wikipedia.org/wiki/Standard_for_the_Uniform_Scheduling_of_Medicines_and_Poisons
ATC code D08ATC code D08
... combinations D08AH01 Dequalinium D08AH02 Chlorquinaldol D08AH03 Oxyquinoline D08AH30 Clioquinol D08AJ01 Benzalkonium D08AJ02 ...
https://en.wikipedia.org/wiki/ATC_code_D08
ATC code D09ATC code D09
D09AA06 Triclosan D09AA07 Cetylpyridinium D09AA08 Aluminium chlorohydrate D09AA09 Povidone-iodine D09AA10 Clioquinol D09AA11 ...
https://en.wikipedia.org/wiki/ATC_code_D09
List of drugs: Cj-ClList of drugs: Cj-Cl
... clioquinol (INN) clioxanide (INN) cliprofen (INN) cliropamine (INN) Clistin clobazam (INN) clobenoside (INN) clobenzepam (INN) ...
https://en.wikipedia.org/wiki/List_of_drugs:_Cj–Cl
ATC code S02ATC code S02
S02AA01 Chloramphenicol S02AA02 Nitrofural S02AA03 Boric acid S02AA04 Aluminium acetotartrate S02AA05 Clioquinol S02AA06 ...
https://en.wikipedia.org/wiki/ATC_code_S02
ClioquinolClioquinol
The zinc ionophore clioquinol was shown in mice to restore zinc levels and stop the growth of prostate tumors. Research at UCSF ... Clioquinol's use as an antiprotozoal drug has been restricted or discontinued in some countries due to an event in Japan where ... Clioquinol is a constituent of the prescription medicine Vioform, which is a topical antifungal treatment. It is also used in ... Clioquinol (iodochlorhydroxyquin) is an antifungal drug and antiprotozoal drug. It is neurotoxic in large doses. It is a member ...
https://en.wikipedia.org/wiki/Clioquinol
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Clioquinol Topical: MedlinePlus Drug InformationClioquinol Topical: MedlinePlus Drug Information
Clioquinol Topical: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Clioquinol comes as a cream, lotion, and ointment to apply to the skin. Clioquinol is usually used two to four times a day for ... Clioquinol is for external use only and may stain your clothes, hair, skin, and nails yellow. Do not let clioquinol get into ... Clioquinol topical is no longer available in the United States. If you are currently using clioquinol, you should call your ...
https://medlineplus.gov/druginfo/meds/a682367.html
Betamethasone / ClioquinolBetamethasone / Clioquinol
Fixed Drug Eruptions Treatment & Management: Medical Care, Consultations, DietFixed Drug Eruptions Treatment & Management: Medical Care, Consultations, Diet
Adverse reactions to medications are common and often manifest as a cutaneous eruption. Drug-induced cutaneous disorders frequently display a characteristic clinical morphology such as morbilliform exanthem, urticaria, hypersensitivity syndrome, pseudolymphoma, photosensitivity, pigmentary changes, acute generalized exanthematous pustulosis, ...
https://www.medscape.com/answers/1336702-37449/which-specialist-consultations-are-recommended-in-the-treatment-of-fixed-drug-eruptions-fde
Zinc Ionophore, COVID-19, Inflammation, Hemoglobin, Clioquinol, MoreZinc Ionophore, COVID-19, Inflammation, Hemoglobin, Clioquinol, More
Zinc, Zinc Ionophore, COVID-19, Inflammation, Hemoglobin, Clioquinol, and More. by Marcus Ettinger , Apr 9, 2020 , Bacteria & ... or clioquinol (CQ), alone and combined with zinc. Only the combinations of the chelators with zinc triggered a rapid increase ... or clioquinol (CQ), alone and combined with zinc. Only the combinations of the chelators with zinc triggered a rapid increase ...
https://www.advancedhealing.com/zinc-ionophore-covid-19-anemia-inflammation-hemoglobin-clioquinol/
Fixed Drug Eruptions Workup: Laboratory Studies, Other Tests, ProceduresFixed Drug Eruptions Workup: Laboratory Studies, Other Tests, Procedures
Adverse reactions to medications are common and often manifest as a cutaneous eruption. Drug-induced cutaneous disorders frequently display a characteristic clinical morphology such as morbilliform exanthem, urticaria, hypersensitivity syndrome, pseudolymphoma, photosensitivity, pigmentary changes, acute generalized exanthematous pustulosis, ...
https://emedicine.medscape.com/article/1336702-workup
Prehospital trauma care reduces mortality. Ten-year results from a time-cohort and trauma audit study in IraqPrehospital trauma care reduces mortality. Ten-year results from a time-cohort and trauma audit study in Iraq
Clioquinol * Community Health Workers * Emergency Medical Services / organization & administration* * Emergency Medical ...
https://pubmed.ncbi.nlm.nih.gov/22304808/?dopt=Abstract
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International Notes Epidemic Neuropathy -- Cuba, 1991-1994International Notes Epidemic Neuropathy -- Cuba, 1991-1994
Tsubaki T, Honma Y, Hoshi M. Neurological syndrome associated with clioquinol. Lancet 1971;1:696-7. ... in Japan during the 1960s implicated use of the antidiarrheal drug clioquinol as a cause of the problem (8); however, the Inoue ...
https://www.cdc.gov/mmwr/preview/mmwrhtml/00025761.htm
Ala Quin Cream: Package Insert / Prescribing Information - Drugs.comAla Quin Cream: Package Insert / Prescribing Information - Drugs.com
Iodochlorhydroxyquin (Clioquinol) is an antifungal agent and a member of a family of drugs called hydroxyquinolines. Chemically ...
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Pyridoxine neuropathy: Correlation of functional tests and neuropathology in beagle dogs treated with large doses of vitamin B6...Pyridoxine neuropathy: Correlation of functional tests and neuropathology in beagle dogs treated with large doses of vitamin B6...
Clioquinol and 2,5-hexanedione induce different types of distal axonopathy in the dog. *G. Krinke, H. Schaumburg, P. Spencer, P ... dogs receiving clioquinol showed a distalAxonopathy confined to the optic tract and the long spinal cord tracts, without any ...
https://www.semanticscholar.org/paper/Pyridoxine-neuropathy%3A-Correlation-of-functional-in-Schaeppi-Krinke/b2ffce89f3eeb2d78f0484de3d97110aef558a29
Guinea Pigs Club :: The Human Victims of Animal-Based Medical Research
CLIOQUINOL: Anti-diarrhoeal drug. Caused 30,000 cases of blindness and/or paralysis in Japan alone and thousands of deaths ...
http://www.guineapigsclub.com/guineapigsclub/article.asp?ID=1
Topical corticosteroid treatment for skin conditions - BPJ 23 September 2009Topical corticosteroid treatment for skin conditions - BPJ 23 September 2009
Betnovate C ointment/cream (+clioquinol) Fucicort (+fusidic acid 2%) Betamethasone dipropionate (0.05%) Diprosone cream/ ...
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Acetaminophen Phenyltoloxamine - Health32
Ala-Quin (Clioquinol Hydrocortisone Topical). August 24, 2010 Alefacept. August 25, 2010 ...
https://www.health32.com/acetaminophen-phenyltoloxamine/
SMART: JmjC domain annotationSMART: JmjC domain annotation
Factor inhibiting HIF-1 alpha in complex with Clioquinol. 3kcy. Factor inhibiting HIF-1 alpha in complex with 8- ...
http://smart.embl-heidelberg.de/smart/do_annotation.pl?BLAST=DUMMY&ACC=SM00558
NIOSHTIC-2 Search Results - Full View
... and the pharmaceutical agents clioquinol (130267), nitrofurantoin (67209), and isoniazid (54853). Among the results of the ...
http://www2a.cdc.gov/nioshtic-2/BuildQyr.asp?s1=acrylamide&f1=%2A&Startyear=&Adv=0&terms=1&EndYear=&Limit=10000&sort=&D1=10&PageNo=7&RecNo=62&View=f&
Frontiers | Nanomedicine: A Promising Way to Manage Alzheimers DiseaseFrontiers | Nanomedicine: A Promising Way to Manage Alzheimer's Disease
The Cu-conjugated NP formulation in the form of chelator clioquinol (CQ) has the potential to reverse the metal precipitation ... 2003). Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Aβ amyloid deposition and toxicity in ... clioquinol), and deferoxamine are being used against AD pathologies and exhibit promising results in AD treatment (Ritchie et ...
https://www.frontiersin.org/articles/10.3389/fbioe.2021.630055/full
Nanomaterials alleviating redox stress in neurological diseases: mechanisms and applications | Journal of Nanobiotechnology |...Nanomaterials alleviating redox stress in neurological diseases: mechanisms and applications | Journal of Nanobiotechnology |...
Compared with commonly used metal chelators, such as clioquinol (CQ) (copper chelator) [147] and deferoxamine (iron chelator) [ ...
https://jnanobiotechnology.biomedcentral.com/articles/10.1186/s12951-022-01434-5
National Ambulatory Medical Care Survey, 1993National Ambulatory Medical Care Survey, 1993
CLIOQUINOL 57068 NEVIRAPINE 57070 CEFPODOXIME 57072 CHONDROITIN 57074 AZITHROMYCIN 57076 LODOXAMIDE TROMETHAMINE 57078 ...
https://wonder.cdc.gov/wonder/sci_data/surveys/namcs/type_txt/namcs93.asp
MH DELETED MN ADDED MNMH DELETED MN ADDED MN
Clioquinol D3.438.810.350.625.400 D3.633.100.810.350.625.400 Clobetasol D4.808.908.93.250 D4.210.500.908.93.250 CLOCK Proteins ...
https://decs.bvs.br/E/mnchg2017.txt
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Clioquinol 60 G Precio generico Laboratorio Novartis. LASALAR Y SIMPLE 1 CMA 3 20 G ALP0270 LABORATORIO ALPHARMA CLIOQUINOL ... 0.01 neoderm f 0.00 acetonido de fluocinolona clioquinol luzolona y 0.00 CLIOQUINOL CREMA LASALAR Y SIMPLE 3 4.00 CLIOQUINOL ... Clioquinol. Todos los derechos reservados Ortopharma 2021 Implementado por Tomalaweb Wordpress Studio ... g 250 de/e 150 fa est.gel/energ 250 de/ea 150 fa est.gel/refres 250 d/ox 150 fa est.gel/sens 250 de/sen 150 fa est Clioquinol ...
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Tungsten - innosoulmed.comTungsten - innosoulmed.com
Tungsten is a metal with a wide range of uses, the largest of which is as tungsten carbide (W2C, WC) in cemented carbides. Cemented carbides (also called hardmetals) are wear-resistant materials used by the metalworking, mining, petroleum and construction industries. Tungsten is widely used in light bulb and vacuum tube filaments, as well as electrodes, because it can be drawn into very thin wire with a high melting point. Tungsten (Wolfram) is used in material for implanted electrodes and in orthopaedic and dental implants as well as in coils to treat intracranial aneurysms.. ...
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cenforce fm 100 - AllDayGenericcenforce fm 100 - AllDayGeneric
Betamethasone / Clioquinol (Iodochlorhydroxyquin)(1). *Betamethasone / Gentamicin / Miconazole(1). *Betamethasone Topical / ...
https://www.alldaygeneric.com/product-tag/cenforce-fm-100/?filter_generic-name=fenofibrate&query_type_generic-name=or
Skin Disorder Archives - Best Meds WebSkin Disorder Archives - Best Meds Web
Select the fields to be shown. Others will be hidden. Drag and drop to rearrange the order. ...
https://www.bestmedsweb.com/product-category/skin-care/skin-disorder/
Allergy Archives - Generic CornerAllergy Archives - Generic Corner
Betnovate C (Betamethasone/Clioquinol). $13.00. - $47.00. Select options. Quick view Add to wishlist ...
https://genericcorner.net/product-category/allergy/
Physiological and pathological aspects of Aβ in iron homeostasis via 5UTR in the APP mRNA and the therapeutic use of iron...Physiological and pathological aspects of Aβ in iron homeostasis via 5'UTR in the APP mRNA and the therapeutic use of iron...
... and some success has also been achieved with clioquinol, another metal-complexion agent [44, 45]. However, clioquinol is highly ... clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial. Arch Neurol. ...
https://bmcneurosci.biomedcentral.com/articles/10.1186/1471-2202-9-S2-S2
Code System Concept
Clioquinol Active Synonym false false 1491975012 Cloquinol Active Synonym false false 1491976013 Iodochlorhydroxyquin Active ...
https://phinvads.cdc.gov/vads/ViewCodeSystemConcept.action?oid=2.16.840.1.113883.6.96&code=387291001
bontress hair serum uses - AllDayGenericbontress hair serum uses - AllDayGeneric
Betamethasone / Clioquinol (Iodochlorhydroxyquin)(1). *Betamethasone / Gentamicin / Miconazole(1). *Betamethasone Topical / ...
https://www.alldaygeneric.com/product-tag/bontress-hair-serum-uses/
BetamethasoneFlumetasoneIodochlorhydroxyquinHydrocortisoneOintmentTopicalDrugSymptomsSide effectsSearchEyesExternalPatientsFlumetasonePivalateAllergic to clioquinolVioformIonophoreAntifungal agentBetamethasone ValerateCreamSigmaSubstanceMedicationWidelyTreatmentGrowthSpecialDrugsSkinLevelsExplainHuman
Betamethasone7
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Flumetasone3
  • Flumetanol Ear Drops: Each ml contains Flumetasone Pivalate BP 0.2 mg and Clioquinol BP 10 mg. (aristopharma.com)
  • known hypersensitivity to iodine, Flumetasone Pivalate, Clioquinol, hydroxyquinolines and other quinoline derivatives or to any other component of this product. (aristopharma.com)
  • Use in lactation: It is not known whether Flumetasone Pivalate or Clioquinol passes into breast milk. (aristopharma.com)
Iodochlorhydroxyquin1
  • Iodochlorhydroxyquin (Clioquinol) is an antifungal agent and a member of a family of drugs called hydroxyquinolines. (drugs.com)
Hydrocortisone1
Ointment1
  • Clioquinol comes as a cream, lotion, and ointment to apply to the skin. (medlineplus.gov)
Topical2
  • Clioquinol topical is no longer available in the United States. (medlineplus.gov)
  • Topical use of Clioquinol-containing preparations may lead to a marked increase in protein-bound iodine (PBI). (aristopharma.com)
Drug3
  • The drug was Clioquinol. (richardpresser.com)
  • They also found that a drug called clioquinol, currently used as an anti-parasitic drug, overcomes the effect of the mutant LRRK2 and restores the acidity of the lysosome and clears out the protein aggregates. (ox.ac.uk)
  • AUTHORS' CONCLUSIONS: There is an absence of evidence as to whether clioquinol (PBT1) has any positive clinical benefit for patients with AD, or whether the drug is safe. (ox.ac.uk)
Symptoms2
  • If you still have the symptoms of infection after you finish the clioquinol, call your doctor. (medlineplus.gov)
  • The difference in mean change from baseline ADAS-Cog score in the clioquinol arm compared with the placebo arm at weeks 24 and 36 was a difference of 7.37 (95% confidence interval (CI) 1.51 to 13.24) and 6.36 (95% CI -0.50 to 13.23), respectively.There was no significant impact on non-cognitive symptoms or clinical global impression. (ox.ac.uk)
Side effects1
Search1
  • SEARCH METHODS: We searched ALOIS, the Cochrane Dementia and Cognitive Improvement Group Specialized Register, on 29 July 2010 using the terms: Clioquinol OR PBT1 OR PBT2 OR "metal protein" OR MPACS OR MPAC. (ox.ac.uk)
Eyes1
  • Do not let clioquinol get into your eyes or mouth, and do not swallow it. (medlineplus.gov)
External1
  • Clioquinol is for external use only and may stain your clothes, hair, skin, and nails yellow. (medlineplus.gov)
Patients1
  • One trial compared clioquinol (PBT1) with placebo in 36 patients and 32 had sufficient data for per protocol analysis. (ox.ac.uk)
Flumetasone2
  • There is no consensus on treatment but clotrimazole 1% ear drops or flumetasone pivalate 0.02% plus clioquinol 1% ear drops are commonly used. (boosmod.com)
  • Fusidic although fusidic acid fucibet + neomycin cicatrin neomycin + polymyxin b maxitrol + tobramycin tobradex flumetasone + clioquinol locorten-vioform fluocortolone + cinchocaine ultraproct + chlorquinaldol locoid c + pbs controls (p = .904). (journeysmobilevet.com)
Pivalate1
  • One patient was allergic to corticosteroids (positive patch-test reactions to both tixocortol pivalate and budesonide) (Fig 2), and the other was allergic to clioquinol in the bag balm she had been applying. (medscape.com)
Allergic to clioquinol1
  • tell your doctor and pharmacist if you are allergic to clioquinol or any other drugs. (medlineplus.gov)
Vioform1
  • His lab produced such drugs as divinyl ether, carbarson, vioform (clioquinol), amphetamines and nalorphine. (nih.gov)
Ionophore4
  • Copper-ionophore treatments [CuII(gtsm), disulfiram & clioquinol] generated toxic levels of reactive oxygen species (ROS) in TRAMP adenocarcinoma cells, but not in normal mouse prostate epithelial cells (PrECs). (jostchemical.com)
  • The anti-fungal drug clioquinol, which can act as a zinc ionophore, can markedly slow the growth of human prostate cancer in nude mice, and has been proposed as a clinical therapy for prostate cancer. (jcmtjournal.com)
  • In vivo , continual intravenous infusion of zinc, injection of zinc acetate directly into tumors, or parenteral administration of the zinc ionophore clioquinol has notably slowed the growth of human prostate cancers in nude mice [ 12 - 14 ] . (jcmtjournal.com)
  • Clioquinol induces autophagy in cultured astrocytes and neurons by acting as a zinc ionophore miha parka,b, sookjeong leeb, hyaeran byunb, yunha kimd, young j. (firebaseapp.com)
Antifungal agent1
  • Quadriderm Cream combines the anti-inflammatory, anti-pruritic and vasoconstrictive agent betamethasone valerate, the wide spectrum antibiotic gentamicin sulfate, the fungicidal agent tolnaftate and clioquinol, an antibacterial and antifungal agent. (everything19dollar.com)
Betamethasone Valerate3
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  • Betnovate (Betamethasone Valerate/Clioquinol) (Betamethasone Valerate) - 0.1% Beta Scalp Application (Betamethasone Valerate) Betamethasone cream is a potent corticosteroid which is applied to the skin to treat severe skin conditions. (dsbuscon.com)
Cream2
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Sigma3
  • Eight weeks old male rats were injected with clioquinol (CQ, Sigma, St. Louis, MO, 30 mg/kg, i.p.) and TPEN (5 mg/kg. (axlinhibitor.com)
  • Clioquinol was dissolved with dimethyl sulfoxide (DMSO, 30 mg/100 mL, Sigma, St. Louis, MO) and then injected by intraperitoneally (i.p). (axlinhibitor.com)
  • Adsorption control tests had been performed by incubating the particular GnRH antibody with GnRH-I1C10 peptide (Sigma) at a focus of 5 Clioquinol g/ml right away at 4C before make use of on brain areas. (ecobling.org)
Substance1
  • they were all made of a substance called Clioquinol but marketed under different brand names and freely available. (chestofbooks.com)
Medication1
  • of providing approved betamethasone biogaran 0.05 solution buvable en gouttes medications using regimens different from that described in the medication's final. (newdelhifinancial.com)
Widely1
  • Work at that time included investigations into the widely available drug Clioquinol, a critical report of special footwear, ground-breaking research into the sexual problems experienced by disabled people, and tests of the 'invalid tricycles' then issued by the then Department of Health and Social Security. (rica.org.uk)
Treatment2
  • If you are currently using clioquinol, you should call your doctor to discuss switching to another treatment. (medlineplus.gov)
  • This loss of intracellular zinc appears to be essential to the viability of the transformed cells, as measures which restore high intracellular zinc levels - exposure to high extracellular zinc, or treatment with zinc ionophores such as pyrithione or clioquinol - slows their proliferation and up-regulates cell death [ 8 - 11 ] . (jcmtjournal.com)
Growth1
  • In particular, administration of clioquinol was associated with an 85% growth retardation of a ZIP-1- deficient human prostate cancer [ 14 ] . (jcmtjournal.com)
Special2
  • SW1 (something special from S. Clioquinol Wray, Country wide Institute of Neurological Illnesses and Heart stroke) elevated against mammalian GnRH-I (Wray et al. (ecobling.org)
  • 1997). A polyclonal sheep antibody, BDS 037 (something special from Dr. A. Caraty, INRA, Nouzilly, France), elevated against mammalian GnRH-I, which detects Clioquinol C-terminal epitopes of GnRH-I (Caraty et al. (ecobling.org)
Drugs2
  • Clioquinol may not be as effective as other drugs to remove aluminum. (marsemb.com)
  • The 5 UTR specific IRE RNA stem loop was first reported in 2002 and has since proven to present a target for chelators and other drugs that inhibit APP translation, such as desferrioxamine, clioquinol, VK-28, piperazine-1, phenserine, tetrathiomolybdate, dimercaptopropanol, paroxetine, azithromycin and a high throughput benzimidazole 5UTR translation blocker designated as JTR-009 [35C39]. (ourworldisblue.com)
Skin2
  • Clioquinol is used to treat skin infections such as eczema, athlete's foot, jock itch, and ringworm. (medlineplus.gov)
  • Clioquinol is for external use only and may stain your clothes, hair, skin, and nails yellow. (medlineplus.gov)
Levels1
  • Animals were returned to their cages when fully awake and ambulatory.Zinc Chelators InjectionTo depress vesicular zinc levels or to chelate extracellular zinc, two zinc chelators, clioquinol and N,N,N0,N-Tetrakis (2-pyridylmethyl) ethylenediamine (TPEN) were used. (axlinhibitor.com)
Explain1
  • Since then, some research has suggested that clioquinol fails to explain all the SMON cases. (nomorefakenews.com)
Human1
  • 13. Radiosensitization of clioquinol and zinc in human cancer cell lines. (nih.gov)
Fixed Drug Eruptions Treatment & Management: Medical Care, Consultations, Diet
Fixed Drug Eruptions Treatment & Management: Medical Care, Consultations, Diet (medscape.com)
Clioquinol tópico: MedlinePlus medicinas
Clioquinol tópico: MedlinePlus medicinas (medlineplus.gov)
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Fixed Drug Eruptions Workup: Laboratory Studies, Other Tests, Procedures (emedicine.medscape.com)
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Pyridoxine neuropathy: Correlation of functional tests and neuropathology in beagle dogs treated with large doses of vitamin B6...
Pyridoxine neuropathy: Correlation of functional tests and neuropathology in beagle dogs treated with large doses of vitamin B6... (semanticscholar.org)
Chelators | SCBT - Santa Cruz Biotechnology
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Biomolecules | Free Full-Text | Targeting α-Synuclein for PD Therapeutics: A Pursuit on All Fronts
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C19 : Cui-cui sur l'accalmie du mois d'août 2020
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Nanomaterials alleviating redox stress in neurological diseases: mechanisms and applications | Journal of Nanobiotechnology |...
Nanomaterials alleviating redox stress in neurological diseases: mechanisms and applications | Journal of Nanobiotechnology |... (jnanobiotechnology.biomedcentral.com)
Tungsten - innosoulmed.com
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Physiological and pathological aspects of Aβ in iron homeostasis via 5'UTR in the APP mRNA and the therapeutic use of iron...
Physiological and pathological aspects of Aβ in iron homeostasis via 5'UTR in the APP mRNA and the therapeutic use of iron... (bmcneurosci.biomedcentral.com)
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Fixed Drug Eruptions Workup: Laboratory Studies, Other Tests, Procedures
Fixed Drug Eruptions Workup: Laboratory Studies, Other Tests, Procedures (medscape.com)
Fixed Drug Eruptions: Background, Pathophysiology, Etiology
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Fixed Drug Eruptions Clinical Presentation: History, Physical Examination, Complications
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