Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.
Works about comparative studies to verify the effectiveness of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques determined in phase II studies. During these trials, patients are monitored closely by physicians to identify any adverse reactions from long-term use. These studies are performed on groups of patients large enough to identify clinically significant responses and usually last about three years. This concept includes phase III studies conducted in both the U.S. and in other countries.
Works about studies that are usually controlled to assess the effectiveness and dosage (if appropriate) of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques. These studies are performed on several hundred volunteers, including a limited number of patients with the target disease or disorder, and last about two years. This concept includes phase II studies conducted in both the U.S. and in other countries.
Works about studies performed to evaluate the safety of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques in healthy subjects and to determine the safe dosage range (if appropriate). These tests also are used to determine pharmacologic and pharmacokinetic properties (toxicity, metabolism, absorption, elimination, and preferred route of administration). They involve a small number of persons and usually last about 1 year. This concept includes phase I studies conducted both in the U.S. and in other countries.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
A plan for collecting and utilizing data so that desired information can be obtained with sufficient precision or so that an hypothesis can be tested properly.
Works about clinical trials involving one or more test treatments, at least one control treatment, specified outcome measures for evaluating the studied intervention, and a bias-free method for assigning patients to the test treatment. The treatment may be drugs, devices, or procedures studied for diagnostic, therapeutic, or prophylactic effectiveness. Control measures include placebos, active medicines, no-treatment, dosage forms and regimens, historical comparisons, etc. When randomization using mathematical techniques, such as the use of a random numbers table, is employed to assign patients to test or control treatments, the trials are characterized as RANDOMIZED CONTROLLED TRIALS AS TOPIC.
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
Works about clinical trials that involve at least one test treatment and one control treatment, concurrent enrollment and follow-up of the test- and control-treated groups, and in which the treatments to be administered are selected by a random process, such as the use of a random-numbers table.
Criteria and standards used for the determination of the appropriateness of the inclusion of patients with specific conditions in proposed treatment plans and the criteria used for the inclusion of subjects in various clinical trials and other research protocols.
Works about controlled studies which are planned and carried out by several cooperating institutions to assess certain variables and outcomes in specific patient populations, for example, a multicenter study of congenital anomalies in children.
Any dummy medication or treatment. Although placebos originally were medicinal preparations having no specific pharmacological activity against a targeted condition, the concept has been extended to include treatments or procedures, especially those administered to control groups in clinical trials in order to provide baseline measurements for the experimental protocol.
Committees established to review interim data and efficacy outcomes in clinical trials. The findings of these committees are used in deciding whether a trial should be continued as designed, changed, or terminated. Government regulations regarding federally-funded research involving human subjects (the "Common Rule") require (45 CFR 46.111) that research ethics committees reviewing large-scale clinical trials monitor the data collected using a mechanism such as a data monitoring committee. FDA regulations (21 CFR 50.24) require that such committees be established to monitor studies conducted in emergency settings.
Elements of limited time intervals, contributing to particular results or situations.
Planned post-marketing studies of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques that have been approved for general sale. These studies are often conducted to obtain additional data about the safety and efficacy of a product. This concept includes phase IV studies conducted in both the U.S. and in other countries.
Precise and detailed plans for the study of a medical or biomedical problem and/or plans for a regimen of therapy.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
A method in which either the observer(s) or the subject(s) is kept ignorant of the group to which the subjects are assigned.
Earlier than planned termination of clinical trials.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
Therapy with two or more separate preparations given for a combined effect.
Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.
The number of units (persons, animals, patients, specified circumstances, etc.) in a population to be studied. The sample size should be big enough to have a high likelihood of detecting a true difference between two groups. (From Wassertheil-Smoller, Biostatistics and Epidemiology, 1990, p95)
A generic concept reflecting concern with the modification and enhancement of life attributes, e.g., physical, political, moral and social environment; the overall condition of a human life.
Small-scale tests of methods and procedures to be used on a larger scale if the pilot study demonstrates that these methods and procedures can work.
Persons who are enrolled in research studies or who are otherwise the subjects of research.
Research aimed at assessing the quality and effectiveness of health care as measured by the attainment of a specified end result or outcome. Measures include parameters such as improved health, lowered morbidity or mortality, and improvement of abnormal states (such as elevated blood pressure).
The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
Establishment of the level of a quantifiable effect indicative of a biologic process. The evaluation is frequently to detect the degree of toxic or therapeutic effect.
A method of comparing the cost of a program with its expected benefits in dollars (or other currency). The benefit-to-cost ratio is a measure of total return expected per unit of money spent. This analysis generally excludes consideration of factors that are not measured ultimately in economic terms. Cost effectiveness compares alternative ways to achieve a specific set of results.
An approach of practicing medicine with the goal to improve and evaluate patient care. It requires the judicious integration of best research evidence with the patient's values to make decisions about medical care. This method is to help physicians make proper diagnosis, devise best testing plan, choose best treatment and methods of disease prevention, as well as develop guidelines for large groups of patients with the same disease. (from JAMA 296 (9), 2006)
The relationship between the dose of an administered drug and the response of the organism to the drug.
The giving of drugs, chemicals, or other substances by mouth.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
Voluntary cooperation of the patient in following a prescribed regimen.
Drugs which have received FDA approval for human testing but have yet to be approved for commercial marketing. This includes drugs used for treatment while they still are undergoing clinical trials (Treatment IND). The main heading includes drugs under investigation in foreign countries.
Voluntary authorization, by a patient or research subject, with full comprehension of the risks involved, for diagnostic or investigative procedures, and for medical and surgical treatment.
An effect usually, but not necessarily, beneficial that is attributable to an expectation that the regimen will have an effect, i.e., the effect is due to the power of suggestion.
Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. The term is often applied to a self-completed survey instrument.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Research that involves the application of the natural sciences, especially biology and physiology, to medicine.
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
Tumors or cancer of the human BREAST.
The return of a sign, symptom, or disease after a remission.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
A subspecialty of internal medicine concerned with the study of neoplasms.
Application of statistical procedures to analyze specific observed or assumed facts from a particular study.
Products in capsule, tablet or liquid form that provide dietary ingredients, and that are intended to be taken by mouth to increase the intake of nutrients. Dietary supplements can include macronutrients, such as proteins, carbohydrates, and fats; and/or MICRONUTRIENTS, such as VITAMINS; MINERALS; and PHYTOCHEMICALS.
Patient involvement in the decision-making process in matters pertaining to health.
Scales, questionnaires, tests, and other methods used to assess pain severity and duration in patients or experimental animals to aid in diagnosis, therapy, and physiological studies.
Any process by which toxicity, metabolism, absorption, elimination, preferred route of administration, safe dosage range, etc., for a drug or group of drugs is determined through clinical assessment in humans or veterinary animals.
Studies to determine the advantages or disadvantages, practicability, or capability of accomplishing a projected plan, study, or project.
Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.
Studies comparing two or more treatments or interventions in which the subjects or patients, upon completion of the course of one treatment, are switched to another. In the case of two treatments, A and B, half the subjects are randomly allocated to receive these in the order A, B and half to receive them in the order B, A. A criticism of this design is that effects of the first treatment may carry over into the period when the second is given. (Last, A Dictionary of Epidemiology, 2d ed)
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)
A regimen or plan of physical activities designed and prescribed for specific therapeutic goals. Its purpose is to restore normal musculoskeletal function or to reduce pain caused by diseases or injuries.
A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
Human experimentation that is intended to benefit the subjects on whom it is performed.
Process that is gone through in order for a drug to receive approval by a government regulatory agency. This includes any required pre-clinical or clinical testing, review, submission, and evaluation of the applications and test results, and post-marketing surveillance of the drug.
Strategy for the analysis of RANDOMIZED CONTROLLED TRIALS AS TOPIC that compares patients in the groups to which they were originally randomly assigned.
A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects.
An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.
A quantitative method of combining the results of independent studies (usually drawn from the published literature) and synthesizing summaries and conclusions which may be used to evaluate therapeutic effectiveness, plan new studies, etc., with application chiefly in the areas of research and medicine.
Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS).
That segment of commercial enterprise devoted to the design, development, and manufacture of chemical products for use in the diagnosis and treatment of disease, disability, or other dysfunction, or to improve function.
Single preparations containing two or more active agents, for the purpose of their concurrent administration as a fixed dose mixture.
A direct form of psychotherapy based on the interpretation of situations (cognitive structure of experiences) that determine how an individual feels and behaves. It is based on the premise that cognition, the process of acquiring knowledge and forming beliefs, is a primary determinant of mood and behavior. The therapy uses behavioral and verbal techniques to identify and correct negative thinking that is at the root of the aberrant behavior.
Antibodies produced by a single clone of cells.
The long-term (minutes to hours) administration of a fluid into the vein through venipuncture, either by letting the fluid flow by gravity or by pumping it.
The teaching or training of patients concerning their own health needs.
Discontinuance of care received by patient(s) due to reasons other than full recovery from the disease.
Antibodies from non-human species whose protein sequences have been modified to make them nearly identical with human antibodies. If the constant region and part of the variable region are replaced, they are called humanized. If only the constant region is modified they are called chimeric. INN names for humanized antibodies end in -zumab.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Use of plants or herbs to treat diseases or to alleviate pain.
The degree to which the individual regards the health care service or product or the manner in which it is delivered by the provider as useful, effective, or beneficial.
Tumors or cancer of the LUNG.
Financial support of research activities.
Any deviation of results or inferences from the truth, or processes leading to such deviation. Bias can result from several sources: one-sided or systematic variations in measurement from the true value (systematic error); flaws in study design; deviation of inferences, interpretations, or analyses based on flawed data or data collection; etc. There is no sense of prejudice or subjectivity implied in the assessment of bias under these conditions.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Component of the NATIONAL INSTITUTES OF HEALTH. Through basic and clinical biomedical research and training, it conducts and supports research with the objective of cancer prevention, early stage identification and elimination. This Institute was established in 1937.
Drug therapy given to augment or stimulate some other form of treatment such as surgery or radiation therapy. Adjuvant chemotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.
A systematic statement of policy rules or principles. Guidelines may be developed by government agencies at any level, institutions, professional societies, governing boards, or by convening expert panels. The text may be cursive or in outline form but is generally a comprehensive guide to problems and approaches in any field of activity. For guidelines in the field of health care and clinical medicine, PRACTICE GUIDELINES AS TOPIC is available.
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
A measure of the quality of health care by assessment of unsuccessful results of management and procedures used in combating disease, in individual cases or series.
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
Directions or principles presenting current or future rules of policy for assisting health care practitioners in patient care decisions regarding diagnosis, therapy, or related clinical circumstances. The guidelines may be developed by government agencies at any level, institutions, professional societies, governing boards, or by the convening of expert panels. The guidelines form a basis for the evaluation of all aspects of health care and delivery.
An operating division of the US Department of Health and Human Services. It is concerned with the overall planning, promoting, and administering of programs pertaining to health and medical research. Until 1995, it was an agency of the United States PUBLIC HEALTH SERVICE.
Disease having a short and relatively severe course.
An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
Preclinical testing of drugs in experimental animals or in vitro for their biological and toxic effects and potential clinical applications.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)
Manipulation of the host's immune system in treatment of disease. It includes both active and passive immunization as well as immunosuppressive therapy to prevent graft rejection.
Treatments with drugs which interact with or block synthesis of specific cellular components characteristic of the individual's disease in order to stop or interrupt the specific biochemical dysfunction involved in progression of the disease.
Hospital or other institutional committees established to protect the welfare of research subjects. Federal regulations (the "Common Rule" (45 CFR 46)) mandate the use of these committees to monitor federally-funded biomedical and behavioral research involving human subjects.
Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chemically-induced adverse conditions due to toxicity, DRUG INTERACTIONS, and metabolic effects of pharmaceuticals.
Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
A class of statistical methods applicable to a large set of probability distributions used to test for correlation, location, independence, etc. In most nonparametric statistical tests, the original scores or observations are replaced by another variable containing less information. An important class of nonparametric tests employs the ordinal properties of the data. Another class of tests uses information about whether an observation is above or below some fixed value such as the median, and a third class is based on the frequency of the occurrence of runs in the data. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1284; Corsini, Concise Encyclopedia of Psychology, 1987, p764-5)
Vaccines or candidate vaccines designed to prevent or treat cancer. Vaccines are produced using the patient's own whole tumor cells as the source of antigens, or using tumor-specific antigens, often recombinantly produced.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
Techniques and strategies which include the use of coding sequences and other conventional or radical means to transform or modify cells for the purpose of treating or reversing disease conditions.
Freedom from exposure to danger and protection from the occurrence or risk of injury or loss. It suggests optimal precautions in the workplace, on the street, in the home, etc., and includes personal safety as well as the safety of property.
Component of the NATIONAL INSTITUTES OF HEALTH. It supports a comprehensive research portfolio that focuses on the biological, social, behavioral and neuroscientific bases of drug abuse on the body and brain as well as its causes, prevention, and treatment. NIDA, NIAAA, and NIMH were created as coequal institutes within the Alcohol, Drug Abuse and Mental Health Administration in 1974. It was established within the NATIONAL INSTITUTES OF HEALTH in 1992.
Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.
Agents used to treat AIDS and/or stop the spread of the HIV infection. These do not include drugs used to treat symptoms or opportunistic infections associated with AIDS.
Substances that reduce the growth or reproduction of BACTERIA.
Statistical models used in survival analysis that assert that the effect of the study factors on the hazard rate in the study population is multiplicative and does not change over time.
Those individuals engaged in research.
A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized form leading to cell death.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
An infant during the first month after birth.
NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).
The influence of study results on the chances of publication and the tendency of investigators, reviewers, and editors to submit or accept manuscripts for publication based on the direction or strength of the study findings. Publication bias has an impact on the interpretation of clinical trials and meta-analyses. Bias can be minimized by insistence by editors on high-quality research, thorough literature reviews, acknowledgement of conflicts of interest, modification of peer review practices, etc.
The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.
A partial or complete return to the normal or proper physiologic activity of an organ or part following disease or trauma.
Groups that serve as a standard for comparison in experimental studies. They are similar in relevant characteristics to the experimental group but do not receive the experimental intervention.
The application of discoveries generated by laboratory research and preclinical studies to the development of clinical trials and studies in humans. A second area of translational research concerns enhancing the adoption of best practices.
A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
The use of humans as investigational subjects.
The giving of advice and assistance to individuals with educational or personal problems.
A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.
Tumors or cancer of the PROSTATE.
The application of modern theories of learning and conditioning in the treatment of behavior disorders.
Expectation of real uncertainty on the part of the investigator regarding the comparative therapeutic merits of each arm in a trial.
Statistical formulations or analyses which, when applied to data and found to fit the data, are then used to verify the assumptions and parameters used in the analysis. Examples of statistical models are the linear model, binomial model, polynomial model, two-parameter model, etc.
Those factors which cause an organism to behave or act in either a goal-seeking or satisfying manner. They may be influenced by physiological drives or by external stimuli.
The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.
Agents that prevent clotting.
Agents that affect the rate or intensity of cardiac contraction, blood vessel diameter, or blood volume.
A distribution in which a variable is distributed like the sum of the squares of any given independent random variable, each of which has a normal distribution with mean of zero and variance of one. The chi-square test is a statistical test based on comparison of a test statistic to a chi-square distribution. The oldest of these tests are used to detect whether two or more population distributions differ from one another.
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
Compounds that inhibit HMG-CoA reductases. They have been shown to directly lower cholesterol synthesis.
Agents and endogenous substances that antagonize or inhibit the development of new blood vessels.
The application of drug preparations to the surfaces of the body, especially the skin (ADMINISTRATION, CUTANEOUS) or mucous membranes. This method of treatment is used to avoid systemic side effects when high doses are required at a localized area or as an alternative systemic administration route, to avoid hepatic processing for example.
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.
Discontinuation of the habit of smoking, the inhaling and exhaling of tobacco smoke.
A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
The process of making a selective intellectual judgment when presented with several complex alternatives consisting of several variables, and usually defining a course of action or an idea.
Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable.
Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.
Therapeutic act or process that initiates a response to a complete or partial remission level.
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
Reduction of high-risk choices and adoption of low-risk quantity and frequency alternatives.
Substances that reduce or suppress INFLAMMATION.
The science and art of collecting, summarizing, and analyzing data that are subject to random variation. The term is also applied to the data themselves and to the summarization of the data.
A measurement index derived from a modification of standard life-table procedures and designed to take account of the quality as well as the duration of survival. This index can be used in assessing the outcome of health care procedures or services. (BIOETHICS Thesaurus, 1994)
The actual costs of providing services related to the delivery of health care, including the costs of procedures, therapies, and medications. It is differentiated from HEALTH EXPENDITURES, which refers to the amount of money paid for the services, and from fees, which refers to the amount charged, regardless of cost.
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
A system for verifying and maintaining a desired level of quality in a product or process by careful planning, use of proper equipment, continued inspection, and corrective action as required. (Random House Unabridged Dictionary, 2d ed)
A publication issued at stated, more or less regular, intervals.
Substances which lower blood glucose levels.
An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.
Institutions specializing in the care of cancer patients.
Conduct and synthesis of systematic research comparing interventions and strategies to prevent, diagnose, treat, and monitor health conditions. The purpose of this research is to inform patients, providers, and decision-makers, responding to their expressed needs, about which interventions are most effective for which patients under specific circumstances. ( accessed 6/12/2009)
Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
Physical activity which is usually regular and done with the intention of improving or maintaining PHYSICAL FITNESS or HEALTH. Contrast with PHYSICAL EXERTION which is concerned largely with the physiologic and metabolic response to energy expenditure.
Systems for the delivery of drugs to target sites of pharmacological actions. Technologies employed include those concerning drug preparation, route of administration, site targeting, metabolism, and toxicity.
Biologically active substances whose activities affect or play a role in the functioning of the immune system.
The introduction of error due to systematic differences in the characteristics between those selected and those not selected for a given study. In sampling bias, error is the result of failure to ensure that all members of the reference population have a known chance of selection in the sample.
A form of therapy that employs a coordinated and interdisciplinary approach for easing the suffering and improving the quality of life of those experiencing pain.
Determination of the degree of a physical, mental, or emotional handicap. The diagnosis is applied to legal qualification for benefits and income under disability insurance and to eligibility for Social Security and workmen's compensation benefits.
A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
The largest country in North America, comprising 10 provinces and three territories. Its capital is Ottawa.
Substances used on humans and other animals that destroy harmful microorganisms or inhibit their activity. They are distinguished from DISINFECTANTS, which are used on inanimate objects.
Therapeutic modalities frequently used in PHYSICAL THERAPY SPECIALTY by PHYSICAL THERAPISTS or physiotherapists to promote, maintain, or restore the physical and physiological well-being of an individual.
Proteins prepared by recombinant DNA technology.
Treatments which are undergoing clinical trials or for which there is insufficient evidence to determine their effects on health outcomes; coverage for such treatments is often denied by health insurers.
A cell line derived from cultured tumor cells.
Fibrinolysin or agents that convert plasminogen to FIBRINOLYSIN.
A situation in which an individual might benefit personally from official or professional actions. It includes a conflict between a person's private interests and official responsibilities in a position of trust. The term is not restricted to government officials. The concept refers both to actual conflict of interest and the appearance or perception of conflict.
A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
Forceful administration into a muscle of liquid medication, nutrient, or other fluid through a hollow needle piercing the muscle and any tissue covering it.
The use of chemical compounds to prevent the development of a specific disease.
Systematic gathering of data for a particular purpose from various sources, including questionnaires, interviews, observation, existing records, and electronic devices. The process is usually preliminary to statistical analysis of the data.
Works about randomized clinical trials that compare interventions in clinical settings and which look at a range of effectiveness outcomes and impacts.
The process of finding chemicals for potential therapeutic use.
Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
Therapeutic approach tailoring therapy for genetically defined subgroups of patients.
The probability that an event will occur. It encompasses a variety of measures of the probability of a generally unfavorable outcome.
The moral obligations governing the conduct of research. Used for discussions of research ethics as a general topic.
Azoles of one NITROGEN and two double bonds that have aromatic chemical properties.
The molecular designing of drugs for specific purposes (such as DNA-binding, enzyme inhibition, anti-cancer efficacy, etc.) based on knowledge of molecular properties such as activity of functional groups, molecular geometry, and electronic structure, and also on information cataloged on analogous molecules. Drug design is generally computer-assisted molecular modeling and does not include pharmacokinetics, dosage analysis, or drug administration analysis.
The use of DRUGS to treat a DISEASE or its symptoms. One example is the use of ANTINEOPLASTIC AGENTS to treat CANCER.
An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and motion sickness, emotional stress, intense pain, food poisoning, and various enteroviruses.
Kirsch, I. & Moncrieff, J (July 2007). "Clinical trials and the response rate illusion". Contemporary Clinical Trials. 28 (4): ... He is the originator of response expectancy theory, and his analyses of clinical trials of antidepressants have influenced ... Contemporary Clinical Trials. 43: 60-62. doi:10.1016/j.cct.2015.05.005. ISSN 1551-7144. PMID 25979317. Kirsch, Irving (2010). ... containing data from trials that had not been published, as well as those data from published trials. Analyses of the FDA data ...
Safer and more effective clinical trials. Evolution[edit]. This section may stray from the topic of the article. Please help ... including heart rate, blood pressure and weight, using simple devices in the patient's home. The information is sent daily to a ... "Journal of Evaluation in Clinical Practice. 18 (1): 56-62. doi:10.1111/j.1365-2753.2010.01522.x. ISSN 1365-2753. PMID 20698917. ... better survival rates among patients fighting serious diseases, an aging U.S. population and longer lifespan are all factors ...
Clinical trials have studied the use of fenfluramine in patients with Dravet syndrome. Results of a Phase III clinical trial ... Archived from the original on 29 September 2017. Retrieved 9 May 2018. "Zogenix drug cuts seizure rate in ... 249-. ISBN 978-3-642-66709-1. "Zogenix ends enrolment in second Phase lll trial of ZX008". Drug Development Technology. Kable. ... Nestler, E. J. (2001). Molecular Neuropharmacology: A Foundation for Clinical Neuroscience. McGraw-Hill. Giuseppe Di Giovanni; ...
PMID 21729314.CS1 maint: multiple names: authors list (link) Brody, Tom (2011). Clinical Trials: Study Design, Endpoints and ... Survival analysis Failure rate and Hazard rate Proportional hazards models Relative risk Spruance, Spotswood; Julia E. Reid, ... A cancer treatment associated with better remission rates might on follow-up be associated with higher relapse rates. The ... "Hazard Ratio in Clinical Trials". Antimicrobial Agents and Chemotherapy. 48 (8): 2787-2792. doi:10.1128/AAC.48.8.2787-2792.2004 ...
On 12 August 2019, it was announced that two clinical trial medications were found to improve the rate of survival in those ... Branswell, Helen (12 August 2019). "For the first time, clinical trial data show Ebola drugs improve survival rates". STAT. ... "Experimental Ebola vaccines elicit year-long immune response/NIH reports final data from large clinical trial in West Africa". ... Paravicini, Giulia; Ross, Aaron (24 November 2018). "Congo approves clinical trials for Ebola treatments". Reuters. Archived ...
Clinical trials are underway. Another technique which aims to divide the spherical ventricle into two elliptical halves is used ... At 3 years only 26 percent were event-free and survival rate was only 60 percent. Most hospitals have abandoned this operation ... Clinical Guideline 5. London: National Institute for Clinical Excellence; 2003 Jul. Available ... the EVEREST Clinical Status Trials". JAMA. 297 (12): 1332-43. doi:10.1001/jama.297.12.1332. PMID 17384438.CS1 maint: multiple ...
This study is currently in Phase-III clinical trials. In July, the FDA approved Truvada as an HIV-preventative. Warner C. ... Current research programs include: "Treatment as prevention" strategies to blunt the rate of new HIV infections. Led by ... This discovery, now moving forward with pre-clinical trials, could one day change the way doctors treat heart attacks. Shinya ... In addition, Gladstone investigators seek to accelerate the movement of basic science discoveries into clinical trials with ...
... is usually measured in 1-year clinical trials of IPF treatments rather than survival. In addition to clinical and physiological ... In IPF patients, the overall mortality at 5 years rate is high but the annual rate of all-cause mortality in patients with mild ... In the first clinical trial of 180 patients (IFIGENIA), NAC was shown in previous study to reduce the decline in VC and DLCO ... "Active Clinical Trials and Investigational Research in IPF". Archived from the original on 2014-09-04. Retrieved 2014-09-04. " ...
Liu, Katherine A.; DiPietro Mager, Natalie A. (31 March 2016). "Women's involvement in clinical trials: historical perspective ... The rate of Wergild suggested that women in these societies were valued mostly for their breeding purposes. The Wergild of ... The trial of Jean-Paul Akayesu, the mayor of Taba Commune in Rwanda, established precedents that rape is an element of the ... The Trial Chamber held that rape, which it defined as "a physical invasion of a sexual nature committed on a person under ...
Clinical trials showed that the new drug is relatively harmless. The most adverse effects were only vomiting and diarrhoea in ... In 1999, an anticancer drug miltefosine was demonstrated to be highly effective (95% cure rate) among Indian patients. This was ... Clinical symptoms include pyrexia (recurring high fever which may be continuous or remittent), enlargement of spleen and liver ... "Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and ...
Clinical trials were conducted at the Netherlands Cancer Institute (NKI). Phase I trials were conducted on NAMI-A in patients ... It was determined that, NAMI-A showed very little toxicity yet managed to decrease the rate of metastasis. Perhaps most ... NAMI-A and KP1019 are two ruthenium anticancer agents that have entered clinical trials. Contrary to what can be found in some ... In order to expand the trial, there needed to be at least one patient in the phase II trial that showed PR as the best response ...
The results of the multi-center clinical trials were published in 2008 reporting a 74% patient acceptance rate. Under this ... Clinical trial results are pending. Peli E. (2000) Field Expansion for Homonymous Hemianopia by Optically Induced Peripheral ... Development of the lens and clinical trials were funded by NEI-NIH Grant EY014723 awarded to Chadwick Optical. ... 9, September 2000 Bowers A, Keeney K, Peli E. (2008) Community-Based Trial of Peripheral Prism Visual Field Expansion Device ...
... it would alter the way in which clinical trials are conducted by allowing new and adaptive trial designs that factor in ... Developing a new drug takes well over a decade and has a failure rate of more than 95%. The most expensive failures happen in ... They also participate in NIH clinical trials. One critical component is that industry partners have agreed to make the data and ... The extent to which clinical trials are required will largely determine the cost of development. Orphan diseases affect fewer ...
Cure rates in clinical trials have ranged from 20 to 45%; although clinical trials often include only younger people and those ... Many of the largest cancer hospitals in the country have access to clinical trials that can be used in refractory or relapsed ... Several FLT3 inhibitors have undergone clinical trials, with mixed results. Two other mutations - NPM1 and biallelic CEBPA are ... The clinical signs and symptoms of AML result from the growth of leukemic clone cells, which tends to interfere with the ...
Most of the findings are from case reports and pre-clinical trials. Due to few clinical trials and lack of information about ... In fact, the cure rate in high-income countries and low-income countries are 80% and 10% respectively. Therefore, lowering the ... Despite a few clinical trials, some trials still highlighted the effectiveness of metronomic therapy as well as cost- ... Yet, more clinical trials are necessary to generalize the method. In conventional chemotherapy, a dose close to the maximum ...
Drop-out rates (in clinical trials) were also unusually high with asenapine. According to a post-hoc analysis of two 3-week ... As of November 2010 asenapine is also in clinical trials at UC Irvine to treat stuttering. Based on its exceptionally high, ... ISBN 978-0-9805790-9-3. Stoner, Steven (2012). "Asenapine: a clinical review of a second-generation antipsychotic". Clinical ... a post hoc analysis of two 3-week clinical trials". BMC Psychiatry. 11: 101. doi:10.1186/1471-244X-11-101. PMC 3152513. PMID ...
... the EXPEDITION trial found an increased rate of mortality associated with these higher doses. The largest clinical trial for ... In all clinical trials, cariporide was given was an intravenous injection. Early clinical trials (see Phase I) showed ... Both Phase III clinical trials for cariporide conclude that it is highly dose-dependent. While earlier trials showed that high ... The primary goals of the GUARDIAN trial were to assess (1) the rate of death or myocardial infarction at day 36 in the four ...
There is a gradual tendency, as therapies become more effective to report higher efficacy rates in clinical trials - but aiming ... PASI can be too unwieldy to use outside of trials, which has led to attempts to simplify the index (SPASI) for clinical use. ... Computer-aided measurement of psoriatic lesion area was found to improve the power of the clinical trial, compared to the ... Computer-aided measurement of psoriatic lesion area in a multicenter clinical trial - Comparison to physician's estimations. J ...
Wong, Chi Heem; Siah, Kien Wei; Lo, Andrew W (31 January 2018). "Estimation of clinical trial success rates and related ... Only 10% of all drugs started in human clinical trials become an approved drug. Drug discovery Drug design Drug development ... Lowe, Derek (2 February 2018). "A New Look at Clinical Success Rates". In the Pipeline, American Association for the ... Of the drugs started in clinical trials on humans, only 10 percent secure F.D.A. approval. ... ...
... there is no evidence from clinical trials to support this. For those with severe persistent asthma not controlled by inhaled ... In 2010 the death rate was 170 per million for males and 90 per million for females. Rates vary between countries by 100 fold. ... Canada, Australia and New Zealand have rates of about 14-15%. The average death rate from 2011 to 2015 from asthma in the UK ... The highest rates are among cyclists (up to 45%), swimmers, and cross-country skiers. While it may occur with any weather ...
Clinical trials have not concluded any effects on pregnant women. However, there is some concern with the behavioral effects of ... Its usage as a secondary or supplementary anesthesia on the mandible has reported a high success rate of above 90%. ... A randomized-double blind clinical trial". International Endodontic Journal. 51 (1): 5-11. doi:10.1111/iej.12773. PMID 28370327 ... Clinical techniques include: Surface anesthesia is the application of an LA spray, solution, or cream to the skin or a mucous ...
In clinical trials, Prolia reduced the rate of vertebral fractures by 61% and the risk of hip fractures by 40%. 2010 In ... Amgen had 11 drugs in Phase III clinical trials. In November 2014 the company announced it was halting all trials of ... The clinical trials primarily enrolled patients with breast or prostate cancer. 2012. Illegal marketing practices. The Los ... In June 2015, Amgen presented Phase II clinical trial data for their anti-CGRP antibody AMG 334 for migraine, approved for sale ...
In clinical trials of dinutuximab, the maximum plasma concentration was 11.5 mcg/mL; the mean steady state volume distribution ... was 5.4 L; the clearance rate was 0.21 L/day; and the average half-life was 10 days. Ch14.18 is a chimeric monoclonal antibody ... it was in Phase III clinical trials, and the institute licensed its rights to Apeiron, a local biotech company. The FDA ... this antibody and several others were brought into clinical trials funded by the National Cancer Institute. Dinutuximab is used ...
... though clinical trials were deemed futile and ultimately halted; however, there were positive changes in the success rate of ... "Considering Eligibility for Studies of Deep Brain Stimulation for Treatment-Resistant Depression Insights From a Clinical Trial ... Jude Medical, BROADEN depression clinical trial failure, futility analysis, Helen Mayberg, deep brain stimulation (DBS) of Cg25 ... Dobbs, David (2018-04-17). "Why a 'Lifesaving' Depression Treatment Didn't Pass Clinical Trials". The Atlantic. Retrieved 2019- ...
"Clinical Trials of Silver Diamine Fluoride in Arresting Caries among Children: A Systematic Review". JDR Clinical and ... Over a 24 month period, it was concluded that there was a higher rate of lesion arrest in teeth treated with 38% SDF (with and ... One of the clinical trials in this systematic review found 38% SDF to be significantly more effective for the prevention of ... A randomised clinical trial conducted by Zhi et al. (2012) found that increasing the frequency of SDF application from once to ...
"Midcourse correction to a clinical trial when the event rate is underestimated: the Look AHEAD (Action for Health in Diabetes) ... She has been involved in at least five clinical world trials, including a Women's health initiative, the SPRINT Trial, the Look ... The clinical trial involves more than 160,000 women. One of their findings was that women who consume two or more diet soft ... Another of her trials was the Systolic Blood Pressure Intervention Trial (SPRINT), which concluded in 2015. Its findings were ...
At least 15 clinical trials have shown that zinc improved weight gain in anorexia. A 1994 trial showed that zinc doubled the ... Common symptoms include increased rates of diarrhea. Zinc deficiency affects the skin and gastrointestinal tract; brain and ... Diagnosis is typically made based on clinical suspicion and a low level of zinc in the blood. Any level below 70 mcg/dl (normal ... However, a review on zinc supplementation trials during pregnancy did not report a significant effect of zinc supplementation ...
It shows a 90% success rate in clinical trials for recurrent C. diff infections. For other illness, it is considered an ... A clinical trial of 18 ASD children undergoing 2-week antibiotic treatment, bowel cleanse, followed by extended FMT showed an ... Resolution rates increased with increased volume and relapse rates increased with decreased mass of FMT. Further research on ... Resolution and relapse rates also differ based on the diluents used to make FMT solutions (water, saline, yogurt, milk or ...
... in clinical trials had atrial fibrillation. Omega-3 acid ethyl esters have not been tested in pregnant women and are rated ... of dietary supplements are not as carefully controlled as prescription products and have not been tested in clinical trials as ... Karalis DG (February 2017). "A Review of Clinical Practice Guidelines for the Management of Hypertriglyceridemia: A Focus on ... Journal of Clinical Lipidology. 9 (6 Suppl): S1-122.e1. doi:10.1016/j.jacl.2015.09.002. PMID 26699442. Weintraub HS (November ...
Phase 3 of the clinical trials were completed in Niger on December 31, 2020. The vaccine has been associated with lower rates ... Clinical trials in the United States, Finland, and Venezuela had found it to be 80 to 100% effective at preventing severe ... These novel approaches are being pursued using animal models and, in the case of the NRRV P2-VP8 candidate, clinical trials. ... A 2014 review of available clinical trial data from countries routinely using rotavirus vaccines in their national immunization ...
Webster MW (July 2011). "Clinical practice and implications of recent diabetes trials". Current Opinion in Cardiology. 26 (4): ... Rates of diabetes in 1985 were estimated at 30 million, increasing to 135 million in 1995 and 217 million in 2005.[18] This ... A Systematic Review and Meta-analysis of Randomized Clinical Trials". JAMA Internal Medicine. 177 (12): 1808-1817. doi:10.1001/ ... "The Journal of Clinical Endocrinology and Metabolism. 99 (10): 3551-60. doi:10.1210/jc.2014-2136. PMC 4483466. PMID 25062463.. ...
... clinical statisticians and pharmacologists, use clinical trials to reveal such effects, allowing physicians to offer a ... In the 17% in which they disagreed, a third reader agreed with one of the initial readers to set a rating. These studies found ... Gorski, DH; Novella, SP (September 2014). "Clinical trials of integrative medicine: testing whether magic works?". Trends in ... Hróbjartsson A, Gøtzsche PC (May 2001). "Is the placebo powerless? An analysis of clinical trials comparing placebo with no ...
Pharmacokinetics: In pre-clinical trials, it is possible to radiolabel a new drug and inject it into animals. Such scans are ... PET scanning does this using radiolabelled molecular probes that have different rates of uptake depending on the type and ... It is used heavily in clinical oncology (medical imaging of tumours and the search for metastases), and for clinical diagnosis ... At present,[when?] by far the most commonly used radiotracer in clinical PET scanning is fluorodeoxyglucose (also called FDG or ...
"Clinical Microbiology Reviews (Review). 22 (4): 552-63. doi:10.1128/CMR.00027-09. PMC 2772359. PMID 19822888.. ... Several trials were conducted in late 2014, and early 2015, but some were abandoned due to lack of efficacy or lack of people ... However, the high rates of death in these species resulting from EBOV infection make it unlikely that these species represent a ... Kuhn, Jens H. (2008). Filoviruses: A Compendium of 40 Years of Epidemiological, Clinical, and Laboratory Studies. Archives of ...
In clinical trials, sarecycline demonstrated clinical efficacy in reducing inflammatory acne lesions as early as three weeks ... Rates appear to be lower in rural societies.[22] While some research has found it affects people of all ethnic groups,[175] ... Archer CB, Cohen SN, Baron SE (May 2012). "Guidance on the diagnosis and clinical management of acne". Clinical and ... Marchetti PM, Barth JH (March 2013). "Clinical biochemistry of dihydrotestosterone". Annals of Clinical Biochemistry. 50 (Pt 2 ...
Murthy P, Nilssen EL, Rao S, McClymont LG (1999). "A randomised clinical trial of antiseptic nasal carrier cream and silver ... in the prevention of recurrent epistaxis in people without active bleeding at the time of treatment-both had a success rate of ... Textbook of clinical pediatrics (2nd ed.). Berlin: Springer. p. 3968. ISBN 9783642022012.. ... randomized controlled trial of antiseptic cream for recurrent epistaxis in childhood". Clin Otolaryngol Allied Sci. 26 (6): 465 ...
Based on its safety and effectiveness in clinical trials,[42] rituximab was approved by the U.S. Food and Drug Administration ... When an NK cell latched onto the cap, it had an 80% success rate at killing the cell. In contrast, when the B cell lacked this ... As of 2017 this use had been explored in some small clinical trials and was undergoing some larger ones; it was unclear as of ... Rituximab has been shown to be an effective rheumatoid arthritis treatment in three randomised controlled trials and is now ...
This lower rate of relapse accounts for the increased success rate of allogeneic transplants, compared to transplants from ... Clinical observations[edit]. A study involving 2408 donors (18-60 years) indicated that bone pain (primarily back and hips) as ... "Adverse events among 2408 unrelated donors of peripheral blood stem cells: results of a prospective trial from the National ... 2008). "Clinical applications of blood-derived and marrow-derived stem cells for nonmalignant diseases". JAMA. 299 (8): 925-36 ...
Based on its safety and effectiveness in clinical trials,[42] rituximab was approved by the U.S. Food and Drug Administration ... When an NK cell latched onto the cap, it had an 80% success rate at killing the cell. In contrast, when the B cell lacked this ... Rituximab did not improve symptoms in patients with chronic fatigue syndrome in a trial published in 2019.[51][52] 22% of ... Rituximab has been shown to be an effective rheumatoid arthritis treatment in three randomised controlled trials and is now ...
"Clinical Practice and Epidemiology in Mental Health. 2 (1): 23. doi:10.1186/1745-0179-2-23. PMC 1584230 . PMID 16968542.. ... "Effects of Evening vs Morning Levothyroxine Intake: A Randomized Double-blind Crossover Trial". Archived from the original on 6 ... and fast heart rate.[1] Use is not recommended in people who have had a recent heart attack.[1] Use during pregnancy has been ... "British Journal of Clinical Pharmacology. 60 (3): 337-41. doi:10.1111/j.1365-2125.2005.02433.x. PMC 1884777 . PMID 16120075.. ...
Clinical laboratory sciences are the clinical diagnostic services that apply laboratory techniques to diagnosis and management ... Trial of the Nuremberg trials, Tuskegee syphilis experiment, and others.. Values such as these do not give answers as to how to ... Vital signs including height, weight, body temperature, blood pressure, pulse, respiration rate, and hemoglobin oxygen ... Subspecialties include transfusion medicine, cellular pathology, clinical chemistry, hematology, clinical microbiology and ...
... randomized clinical trials in singleton and twin pregnancies found that the cervical pessary did not result in a lower rate of ... should be used only in the context of a clinical trial or research protocol. While cerclage is generally a safe procedure, ... "A Randomized Trial of a Cervical Pessary to Prevent Preterm Singleton Birth". The New England Journal of Medicine. 374 (11): ... a randomized controlled trial". American Journal of Obstetrics and Gynecology. 214 (1): 3.e1-9. doi:10.1016/j.ajog.2015.08.051 ...
In clinical trials involving more than 10,000 people, the vaccine, called LYMErix, was found to confer protective immunity to ... from the current levels of 60 or more deer per square mile in the areas of the country with the highest Lyme disease rates) may ... "European Journal of Clinical Chemistry and Clinical Biochemistry (Submitted manuscript). 32 (9): 685-9. doi:10.1515/cclm. ... Stanek G, Reiter M (April 2011). "The expanding Lyme Borrelia complex--clinical significance of genomic species?". Clinical ...
Ernst E (December 2009). "Spinal manipulation for asthma: a systematic review of randomised clinical trials". Respir Med. 103 ( ... In the U.S., chiropractors perform over 90% of all manipulative treatments.[209] Satisfaction rates are typically higher for ... Ernst E (2009). "Chiropractic spinal manipulation for infant colic: a systematic review of randomised clinical trials". Int J ... Ernst E, Posadzki P (2012). "Reporting of adverse effects in randomised clinical trials of chiropractic manipulations: a ...
... application to initiate pilot Phase II clinical trials in the United States. Also, in 2005, the United States Department of ... the ADHD rating scale and the sub-scales related to attention and hyperactivity which are used for the approval of all ... In early March 2006 Cortex reported that, in a small pilot Phase II study, CX717 had demonstrated positive clinical and ... It affects the neurotransmitter glutamate, with trials showing the drug improves cognitive functioning and memory. In 2005 the ...
A variety of experimental therapies are available through clinical trials.. Survival rates in primary brain tumors depend on ... "Clinical July 2014. Archived from the original on 26 November 2011.. ... The central nervous system cancer survival rate in children is approximately 60%. The rate varies with the type of cancer and ... This has been under investigation since 2010 in a Phase I/II clinical trial for the potential treatment of recurrent high-grade ...
Ashraf Mozayani; Lionel Raymon (18 September 2011). Handbook of Drug Interactions: A Clinical and Forensic Guide. Springer ... a phase III randomised trial". Br J Urol. 52 (3): 208-15. doi:10.1111/j.1464-410x.1980.tb02961.x. PMID 7000222.. ... Tissues in which DHT forms at a high rate include the prostate gland, skin, and hair follicles.[37][111] In accordance, DHT is ... Kavoussi P, Costabile RA, Salonia A (17 October 2012). Clinical Urologic Endocrinology: Principles for Men's Health. Springer ...
The overall mortality rate is estimated to be 1%, but during epidemics, mortality can climb as high as 50%. The mortality rate ... "British Medical Journal (Clinical research ed.). 285 (6347): 1001-1002. doi:10.1136/bmj.285.6347.1001. PMC 1500383 . PMID ... Work on a vaccine is continuing, with multiple approaches showing positive results in animal trials.[23] ... I. Clinical description and pathological findings". Am. J. Trop. Med. Hyg. 19 (4): 670-6. PMID 4246571. Archived from the ...
ref name="pmid21198555",{{cite journal,author=Dicpinigaitis PV,first=,date=May 2011,title=Cough: an unmet clinical need,url=, ... The 3-fold increase in the rate of recovery from the common cold is a clinically important effect. The optimal formulation of ... The VIDARIS Randomized Controlled Trial,/subtitle,,url=,journal=JAMA: The Journal of the American Medical Association,language= ... Journal of Clinical Pharmacy and Therapeutics,language=en,volume=31,issue=4,pages=309-19,doi=10.1111/j.1365-2710.2006.00754.x, ...
Altinicline has undergone Phase II clinical trials. Castro-Stephens coupling Heck reaction Stille reaction Suzuki reaction ... Depending on the rate of the competition between amine and alkyne in the substitution of one ligand in this complex, an ... Cu(I) is a co-catalyst in the reaction, and is used to increase the rate of the reaction. The Sonogashira reaction is typically ... This step is believed to be the rate-limiting step of the reaction. Complex B reacts in a transmetallation with the copper ...
American Journal of Clinical Nutrition. USA. 34 (3): 362-6. doi:10.1093/ajcn/34.3.362. PMID 6259925.. ... 2003). "A randomized trial of a low-carbohydrate diet for obesity". N. Engl. J. Med. 348 (21): 2082-90. doi:10.1056/ ... may slightly increase the mortality rate for individuals who are otherwise healthy.[6][7][8] ... "The American Journal of Clinical Nutrition. 74 (5): 579-584. doi:10.1093/ajcn/74.5.579. PMID 11684524. Retrieved 22 December ...
Clinical trials were commenced for moclobemide's effectiveness in the treatment of depression.[130] It was first approved in ... Results of new subscales of the Hamilton Depression Rating Scale". Clin Neuropharmacol. 16 Suppl 2: S55-62. PMID 8313398.. ... imipramine in bipolar depression: a multicentre double-blind clinical trial". Acta Psychiatrica Scandinavica. 104 (2): 104-109 ... While not generally recommended as a monotherapy for bipolar depression (as with all antidepressants) in one clinical trial it ...
According to a 2013 Cochrane review, listening to music may improve heart rate, respiratory rate, and blood pressure in those ... Grocke, D. & Wigram, T. (2007). Receptive methods in music therapy: Techniques and clinical applications for music therapy ... "Music therapy for in-patients with schizophrenia: exploratory randomised controlled trial". The British Journal of Psychiatry ... despite the fact that mean scores on the Depression Self-Rating Index and the Behavior Rating Index decreased (Hilliard, 2001 ...
... systematic review and meta-analysis of controlled trials with objectively measured outcomes (EarlyBird 54). BMJ (Clinical ... Declining rates of physical activity in the United States: what are the contributors?. Annu Rev Public Health (Review). 2005, ... BMJ (Clinical research ed.) (Meta-analysis). 2012-05-16, 344: e2088. PMC 3355191. PMID 22596383. doi:10.1136/bmj.e2088.. ... National Institute for Health and Clinical Excellence)在2006年發表了肥胖診斷與治療的臨床指引,以及針對非醫療組織(比方說地方政府)
Elevated levels of stress are also linked to high rates of burnout, absenteeism and diagnostic errors, and reduced rates of ... These include psychiatrists, psychiatry physician assistants, clinical psychologists, occupational therapists, clinical social ... and active training reduce the risk of contamination but that more randomized controlled trials are needed for how best to ... These include physiatrists, physician assistants, rehabilitation nurses, clinical nurse specialists, nurse practitioners, ...
A meta-analysis of four randomized controlled trials comparing treatments of membranous nephropathy showed that regimes ... Clinical Journal of the American Society of Nephrology. 1 (4): 723-9. doi:10.2215/CJN.01211005. PMID 17699279.. ... higher remission rates of nephrotic syndrome and less adverse reactions than after traditional treatment with cytotoxic drugs ... "Membranous nephropathy in children: clinical presentation and therapeutic approach". Pediatric Nephrology. 25 (8): 1419-28. ...
Counterfeit drugs have even been known to have been involved in clinical drug trials.[citation needed] ... If the fake drugs market grows at the current rate of 25%, it will cross US$10 billion mark by 2017. Trade in fake drugs is ... Still in trial stages, the implementers of the platform announced in 2009 that they are in partnership with Ghana's Ministry of ...
有一些可以評估更年期對女性影響的方式,例如格林更年期量表問卷(英语:Greene Menopause Index)[40]、塞萬提斯量表(Cervantes scale)[41]及更年期評分量表(Menopause rating scale)[20]。 ... The Journal of Clinical Endocrinology & Metabolism: 3040-43. [27 September 2013]. doi:10.1210/jc.2007-0581.. [永久失效連結] ... The STAR Trial: Evidence for Raloxifene as a Breast Cancer Risk Reduction Agent for Postmenopausal Women. J Natl Compr Canc ... EMAS clinical guide: Assessment
National Institute for Health and Clinical Excellence(英语:National Institute for Health and Clinical Excellence). 11 Clinical ... 多囊卵巢綜合症與超重或肥胖有關,減肥是恢復規律月經的最有效方法,但是很多女性很難達到並維持顯著的體重減輕。 2013年的科學評估發現,與飲食組成無關,重量和體重組成、懷孕率(英语:Pregnancy rate)、月經規律、排卵、雄激素過高、胰島素抗性、脂 ... a systematic review of randomized
The rate is still among the highest in Latin America.[19] Sexual health[edit]. According to the UNAIDS report of 2003 there ... Randomized, placebo-controlled trial of inactivated poliovirus vaccine in Cuba. N Engl J Med. 2007 Apr 12;356(15):1536-44. Free ... Basic work teams within the polyclinics supervise and evaluate the neighborhood and clinical health work of the family medicine ... Abortion rates, which are high in Cuba, increased dramatically during the 1980s, but had almost halved by 1999 and declined to ...
Differences in survival rates between rural and urban cancer patients may be due to the kind of care they receive, a review of ... home/cancer center/ cancer a-z list/ clinical trials balance out cancer survival rates article ... "But clinical trials are a key difference here. In trials, patients are uniformly assessed, treated, and followed under a strict ... a review of cancer clinical trials contends.. Research has shown that cancer patients in rural areas have lower survival rates ...
When conducting clinical trials, ensuring rating consistency is important, but can prove to be quite difficult to obtain. ... Within the field of clinical trials, rating is the process by which a human evaluator subjectively judges the response of a ... Hall C, Dallabrida SM (16 March 2015). "Why Rater Training Matters in Clinical Trials: A Science Overview". Clinical Leader. ... Targum SD (June 2006). "Evaluating rater competency for CNS clinical trials". primary. Journal of Clinical Psychopharmacology. ...
... limits of MRI guided HDR brachytherapy and will be critical for the judicious conduct of a subsequent phase II clinical trial. ... High-Dose-Rate Brachytherapy. The safety and scientific validity of this study is the responsibility of the study sponsor and ... This trial will strive to demonstrate improvements in technical performance under MRI-guidance, while exploring a novel ... a research program testing the early technical and clinical performance of a novel procedure for MRI-guided high-dose-rate (HDR ...
This may subsequently lead to design of randomized controlled trials examining the effects of earlier intervention with the aim ... Clinical Observational Study Using Iohexol to Measure Perioperative Glomerular Filtration Rate in Patients Undergoing Robotic ... Measurement of Perioperative Glomerular Filtration Rate. The safety and scientific validity of this study is the responsibility ... Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our ...
Laquinimod Beneficial in Reducing Multiple Sclerosis Relapse Rate in Clinical Trials. By Denise Reynolds RD G+ Apr 14 2011 - 10 ... The results from this study will be presented during the Clinical Trials Session at the American Academy of Neurology 63rd ... An experimental drug developed by Teva Pharmaceutical Industries has been found in clinical studies to reduce MS relapse rate ... "In this trial, what I think was surprising was that the effect on disability is larger than the effect on relapses," said Dr. ..., a new web site that provides user-generated reviews for clinical trials as well as easy access to participate ... Goes Live and Begins Rating Clinical Trials. Thursday, September 15, 2016 Clinical Trials News ... create a community where patients in clinical trials share and rate their experiences; b) allow searching for clinical trials ... makes it easy to join a clinical trial. By having an easy-to-use interface, those looking for a clinical trial ...
... a multicenter randomized trial. Clin Infect Dis. 2015 Jun 15;60(12):1752-9. doi: 10.1093/cid/civ162. Epub 2015 Mar 3.. ... Local Gentamicin Application to Reduce Postoperative Infection Rate. Official Title ICMJE Local Gentamicin Application to ... Reduce Postoperative Infection Rate in Hemiarthroplasty After Fracture of the Proximal Femur: a Randomized Controlled Trial. ... Prosthetic joint infection is a devastating complication, and the infection rate is high in this group of elderly patients. ...
Assessing Rates of Hypoglycemia as an End Point in Clinical Trials. Douglas B. Muchmore, Lutz Heinemann, William Tamborlane, ... Assessing Rates of Hypoglycemia as an End Point in Clinical Trials. Douglas B. Muchmore, Lutz Heinemann, William Tamborlane, ... Assessing Rates of Hypoglycemia as an End Point in Clinical Trials Message Subject (Your Name) has forwarded a page to you from ... Unfortunately, from the clinical trial perspective, it is relatively rare, occurring at a rate of about 13.5 episodes per 100 ...
The recent increase in survival for children with cancer is due to more patients taking part in clinical trials, according a ... Boost in childhood cancer survival rates due to clinical trials. News report ... border="0" />Boost in childhood cancer survival rates due to clinical trials ... The recent increase in survival for children with cancer is due to more patients taking part in clinical trials, according a ...
Improving pediatric practice immunization rates through distance-based quality improvement: a feasibility trial from PROS. Clin ... Increasing HPV Immunization Rates: The Rural Adolescent Vaccine Enterprise (RAVE). The safety and scientific validity of this ... Increasing HPV Immunization Rates: The Rural Adolescent Vaccine Enterprise Official Title ICMJE Increasing Human Papillomavirus ... How should immunization rates be measured in the office setting? A study from PROS and NMA PedsNet. Clin Pediatr (Phila). 2008 ...
We compare two statistical methods for combining event rates from several studies. Both methods treat each study as a separate ... Clinical Trials as Topic / statistics & numerical data*. Data Interpretation, Statistical*. Humans. Meta-Analysis as Topic*. ... We compare two statistical methods for combining event rates from several studies. Both methods treat each study as a separate ... The DerSimonian and Laird modified Cochran method (D&L) produces a weighted average of rate differences, where the weights ...
ReferralPlus Increases Match Rate For Clinical Trial Volunteers By Over 66%. By News Staff , April 21st 2014 06:00 AM , Print ... if they could help increase enrollment rates by triaging/matching patients who disqualified from one clinical trial to trials ... It was created because 95% of patients who respond to a trial recruitment advertisement do not qualify and/or enroll in that ...
Randomized Controlled Trial; Research Support, Non-U.S. Govt ... Impaired results of a randomised double blinded clinical trial ... Consequently, the trial was stopped after two years. Ninety-five percent of the measurements of the AAA were measured within 2 ... Two-year lasting prospective randomised double-blinded intervention trial.. SETTING: Hospital-based mass screening for AAA with ... of propranolol versus placebo on the expansion rate of small abdominal aortic aneurysms.. Lindholt JS1, Henneberg EW, Juul S, ...
University Cancer Center are investigating a new avenue of treatment to help boost poor pancreatic cancer survival rates. ... Clinical trial looks to improve pancreatic cancer survival rates. February 12, 2013 in Medicine & Health / Cancer Researchers ... "Clinical trial looks to improve pancreatic cancer survival rates" February 12, 2013 ... "This is why our cancer center is taking a leading role in advancing clinical trials examining the effectiveness of combination ...
Effect of Vitamin D on Ovulation Rate in Women With Polycystic Ovary Syndrome ... Clinical trial for Anovulation , polycystic ovary disease , Ovulation , OVARIAN CYST , Ovarian Function , Ovarian disorder , ... This is a randomized double-blind controlled trial on the effect of vitamin D supplementation to assess the ovulation rate of ... Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to ...
Accordingly, the necessary size, duration, and cost of all-cause mortality trials in this population are substantial and likely ... The all-cause mortality rate is relatively low in patients with IPF with mild to moderate impairment in lung function. ... Implications for the design and execution of clinical trials Am J Respir Crit Care Med. 2014 Apr 1;189(7):825-31. doi: 10.1164/ ... Rationale: FVC has emerged as a standard primary endpoint in clinical trials evaluating novel therapies for patients with ...
Methods: Clinical trials of etanercept in AS (four placebo-controlled; one active-controlled; three open-label) were examined ... Outcomes of a multicentre randomised clinical trial of etanercept to treat ankylosing spondylitis. Ann Rheum Dis 2004;63:1594- ... Results: In placebo-controlled trials, the uveitis rate per 100 subject years (95% CI) for etanercept (8.6 (4.5 to 14.2)) was ... In double-blind, placebo-controlled trials, the uveitis rate with etanercept was lower than with placebo (8.6 and 19.3 per 100 ...
Pre-Clinical Trial Shows BloodSTOP iX Battle Matrix Has 100% Survival Rate in Military Standard Test of Severe Arterial ... survival rate during pre-clinical trials testing severe femoral artery lacerations mimicking a battlefield gunshot or shrapnel ... The pre-clinical study, which was conducted on swine over a two-week period, examined BloodSTOP iX Battle Matrixs ... This pre-clinical GLP study demonstrated the efficacy of BloodSTOP iX Battle Matrix in controlling severe bleeding in several ...
Results of the Triplet Clinical Trial at HonorHealth Research Institute based on the TGen Triple research presented at ASCO-GI ... TGen-HonorHealth Research Institute clinical trial reports high rate of tumor shrinkage among patients with advanced pancreatic ... This pilot clinical trial began in 2013 through a partnership between the HonorHealth Research Institute and TGen. It was ... Results of the Triplet Clinical Trial at HonorHealth Research Institute based on the TGen Triple research presented at ASCO-GI ...
Improving the success rate of clinical trials also has an economic impact. Parkers team found that using the HER2 biomarker in ... There are currently no clear estimates of success rates in clinical trials for breast cancer drugs and the factors that can ... "It provides us with concrete initial evidence that the use of a biomarker can help improve clinical trial success rates in ... To test this hypothesis, Parker and his team examined the clinical trial success rates for drugs tested on breast cancer ...
Glomerular filtration rate measurements in clinical trials. Modification of Diet in Renal Disease Study Group and the Diabetes ... Glomerular filtration rate measurements in clinical trials. Modification of Diet in Renal Disease Study Group and the Diabetes ... Glomerular filtration rate measurements in clinical trials. Modification of Diet in Renal Disease Study Group and the Diabetes ... Glomerular filtration rate measurements in clinical trials. Modification of Diet in Renal Disease Study Group and the Diabetes ...
Home » Health Conditions » Clinical Trials » Your Cancer Survival Rate May Be A Matter of Participating in Clinical Trials, or ... Your Cancer Survival Rate May Be A Matter of Participating in Clinical Trials, or Not. *Facebook ... A review of cancer clinical trials contends that the differences in survival rates between rural and urban cancer patients may ... In the five years after enrollment in the trials, there was no significant difference in survival rates between rural and urban ...
Randomized Controlled Clinical Trial of a Home Care Unit Intervention to Reduce Readmission and Death Rates in Patients ... This clinical trial shows that the short, basically educational programme tested has, at best, a very modest effect in the ... This was a randomized controlled clinical trial carried out among patients of a tertiary care hospital following approval by ... Methods. This randomized controlled clinical trial involved 279 HF patients who were discharged from a tertiary-care hospital ...
Objective: Participation rates in clinical trials are low in teenagers and young adults (TYA) with cancer. Whilst the ... Are survival and mortality rates associated with recruitment to clinical trials in teenage and young adult patients with acute ... 7 more authors) (2017) Are survival and mortality rates associated with recruitment to clinical trials in teenage and young ... Relative survival rates were calculated for trial and non-trial patients and observed differences were modelled using a ...
Abstract TP28: Impact of Variations in Thrombolysis in Cerebral Infarction Grading Scheme Between Clinical Trials on Rates of ... trial investigators (filling all branches but with delay) and definition used by Multicenter Randomized Clinical trial of ... Conclusions: The differences in definitions used between trials and impact upon rates of partial recanalization (TICI 2b) ... Background: There have been different methods in clinical trials to quantify partial angiographic recanalization after ...
... a randomized clinical trial. Kardiochirurgia i Torakochirurgia Polska/Polish Journal of Thoracic and Cardiovascular Surgery. ... a randomized clinical trial. Kardiochirurgia i Torakochirurgia Polska/Polish Journal of Thoracic and Cardiovascular Surgery, 10 ... a randomized clinical trial". Kardiochirurgia i Torakochirurgia Polska/Polish Journal of Thoracic and Cardiovascular Surgery 10 ... a randomized clinical trial. Kardiochirurgia i Torakochirurgia Polska/Polish Journal of Thoracic and Cardiovascular Surgery, 10 ...
TitleDose finding methods based on cure rate model in phase I cancer clinical trials ... Dose finding methods based on cure rate model in phase I cancer clinical trials. Retrieved from ... DescriptionThe main goal of a Phase I cancer clinical trial is to identify the maximum tolerated dose (MTD) of a new drug ... SubjectStatistics and Biostatistics, Clinical trials, Cancer--Research, Cancer--Treatment, Drugs--Dose-response relationship ...
There is often a delay of a few days before the trial is available on the clinical trials website.. Clinical trial records are ... Clinical Trials: SEARCH[Study] TILT[Study:StudyFirstPostDate] AREA[BasicSearch] stone free rate. ... There is often a delay of a few days before the updated trial is available on the clinical trials website.. Specify a From date ... The last updated date is the most recent date when changes to a clinical trial were submitted to ...
We conducted a retrospective study of nine trials at the Nottingham Clinical Trials Unit (NCTU) that were open to recruitment ... In large, multi-centre trials, communication between the coordinating centre and trial sites is essential. A commonly used ... In the 8 weeks prior to the date of the investigator meeting, 82 sites (across nine trials) were open to recruitment; 60 of ... Anecdotally, there is a perception that recruitment rates may increase after holding such a meeting. The aim of this before-and ...
Find out about how taking part in a clinical trial may affect different types of insurance, including travel insurance, life ... Rate this page: Select rating. Give Getting insurance if you are in a clinical trial 1/5. Give Getting insurance if you are in ... border="0" />What you should be told about a clinical trial. " border="0" />Getting insurance if you are in a clinical trial ... How a trial may affect your insurance. Taking part in a clinical trial may affect some types of insurance that you already have ...
  • This pre-clinical GLP study demonstrated the efficacy of BloodSTOP iX Battle Matrix in controlling severe bleeding in several important parameters including time of achieving initial hemostasis and post-treatment blood loss, showcasing its potential usage in the battlefield. (
  • Randomized clinical trials are the ideal means for evaluating the efficacy and safety of medical drugs and devices. (
  • Phase II studies in non-small cell lung cancer (NSCLC) and other cancers are designed to test the efficacy of cancer therapies to identify compounds with promising activity that should be considered for testing in phase III randomized trials. (
  • There is a well-established pathway of anticancer drug development that progresses from dose-finding phase I studies through phase II efficacy trials, to phase III randomized trials to determine benefit compared with accepted standard treatment regimens ( 1 ). (
  • The primary endpoints for this essential for any laboratory implementing a long term regulatory study were based on the proportions of vaccinees mounting anti- compliant clinical trial of vaccine efficacy. (
  • ROCKVILLE, Md.--( BUSINESS WIRE )-- Emergent BioSolutions Inc. (NYSE:EBS) announced today that its joint venture with the University of Oxford (Oxford), the Oxford-Emergent Tuberculosis Consortium (OETC), has vaccinated the last of the 2,784 infants in its Phase IIb efficacy trial evaluating MVA85A, the world's most clinically advanced tuberculosis (TB) vaccine in development. (
  • CytRx Corporation (NASDAQ:CYTR), a biopharmaceutical research and development company engaged in the development of high-value human therapeutics, has filed a report with the U.S. Food and Drug Administrations (FDA) in response to the Agency's partial clinical hold on the Company's Phase 2b efficacy clinical trial with its molecular chaperone regulator drug candidate arimoclomol for the treatment of amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease ). (
  • Despite the efficacy of bariatric surgery in adolescents and the increasing rates of adolescent obesity, the use of bariatric surgery remains low. (
  • ETHOS is a randomised, double-blinded, multi-centre, parallel-group, 52-week trial to assess the efficacy and safety of Breztri Aerosphere in symptomatic patients with moderate to very severe COPD and a history of exacerbation(s) in the previous year. (
  • Dulaglutide is currently in Phase III clinical trials, where it will continue to be evaluated on its efficacy to lower blood glucose levels, overall safety, weight effects and effects on cardiovascular outcomes. (
  • 1 These criteria required "availability of good manufacturing practice grade vials after lot release for clinical trials, and 100 percent efficacy had been documented in nonhuman primates with acceptable preclinical safety" ( WHO, 2015c ). (
  • With these vaccine candidates selected, debate shifted to concerns regarding the best trial designs for testing their efficacy. (
  • CureVac's mRNA vaccine reaches an efficacy level of just 47 percent in a clinical trial . (
  • But in the new study, researchers found that the survival rate gap shrank when urban and rural cancer patients were all participants in clinical trials. (
  • PALO ALTO, CA--(Marketwired - Apr 29, 2015) - LifeScience Plus , a Silicon Valley-based biotechnology company revolutionizing wound-care, today announced that its military-grade new hemostatic wound-care product, BloodSTOP iX Battle Matrix, has achieved a 100% survival rate during pre-clinical trials testing severe femoral artery lacerations mimicking a battlefield gunshot or shrapnel wound. (
  • BloodSTOP iX was the only hemostatic wound-care product in the study to achieve a 100% survival rate -- meaning all of the pigs that were treated with BloodSTOP iX survived. (
  • Vicky Feng, CEO of Life Science Plus, said, "We are proud to announce that BloodSTOP iX Battle Matrix is the only hemostatic technology that has achieved a 100% survival rate in military-standard testing. (
  • The median overall survival rate of 16.5 months exceeds the historical average survival of six-12 months with standard chemotherapy. (
  • The prognosis and survival rate of cervical cancer depends on the stage and type of cervical cancer and tumor size. (
  • The authors of a more recent study estimated that the 5-year overall survival rate in people with advanced melanoma who were treated with Keytruda was 34 percent. (
  • The same study found that the 4-year overall survival rate was 46 percent in people who were treated with Opdivo alone, compared to 30 percent in people treated with Yervoy alone. (
  • What does the five-year survival rate for uterine cancer mean? (
  • The five-year survival rate for uterine cancer is a statistic that measures how many people are alive five years after being diagnosed with the disease, says Mayo Clinic. (
  • The rate is expressed as a percentage, so a 60 percent survival rate means 60 people out of 100 are still alive after five years. (
  • The five-year survival rate for women diagnosed with local uterine cancer is 95 percent, notes the American Society of Clinical Oncology. (
  • Patients diagnosed with regional spread of the disease have a 68 percent five-year survival rate. (
  • When the diagnosis shows the cancer has spread more distantly, the five-year survival rate is 17 percent. (
  • Cancer of the omentum is linked to ovarian cancer, which generally has a 45 percent survival rate after 5 years, according to the American Cancer Society. (
  • The prognosis for cervical cancer varies from a 5 percent survival rate to a 95 percent survival rate after five years, according to Cancer Research UK. (
  • What is the survival rate of bone cancer, and how serious is the disease? (
  • The five-year relative survival rate for bone cancer in both children and adults is approximately 70 percent, according to the American Cancer Society. (
  • although breast cancer awareness and survival have increased significantly in the United States for all races, several studies have cited a significantly worse survival rate for African-American women compared to white women. (
  • In fact, our research confirms that the survival rate for human papillomavirus-related oropharynx cancer is higher than non HPV-related cancer. (
  • This is a huge advancement, and the biggest boost in survival rates we've seen in over a decade, considering the 5 year survival rate for Pancreatic Cancer in general is hovering only around the 7% mark. (
  • The primary endpoint was annualized relapse rate and secondary endpoints included the cumulative number of gadolinium-enhancing and new or newly enlarging T2 lesions. (
  • FVC has emerged as a standard primary endpoint in clinical trials evaluating novel therapies for patients with idiopathic pulmonary fibrosis (IPF). (
  • However, it has recently been proposed that all-cause mortality or a composite comprised of all-cause mortality and all-cause nonelective hospitalization be adopted as the standard primary endpoint for IPF clinical trials. (
  • In this full data set analysis, treatment with arimoclomol adjunct to routine clinical care resulted in a 74% reduction in disease progression (p-value=0.0506) as measured by the primary endpoint, 5-domain NPC Clinical Severity Scale (NPC-CSS). (
  • In agreement with the FDA, treatment response defined as no change or improved on the Clinical Global Impression of Improvement scale (CGI-I) was included as a co-primary endpoint. (
  • A responder rate of more than 50% in the placebo control group impeded the ability to show an overall effect on this endpoint. (
  • The clinical benefit rate (CBR) at 16 weeks served as the study's primary endpoint. (
  • Outcomes in the ETHOS trial included, as a primary endpoint, the rate of moderate or severe exacerbations. (
  • The primary endpoint of the study was the frequency of relapses in patients treated up to 24 months (annualized relapse rate)[4]. (
  • The hypothesis, based on positive results in a pilot study [ 14 ], was that this combined anabolic treatment would reduce the rate of hospital admissions, an important clinical endpoint, in this vulnerable group of older people. (
  • Achieving a DR was associated with clinical benefits such as improved OS and QoL and prolonged TFI, thus supporting the usefulness of DR as a meaningful immunotherapy clinical trial endpoint. (
  • To this end, the endpoint of durable response rate (DRR) has been proposed, which includes standard response criteria and a prospective durability dimension. (
  • The primary endpoint was the rate of GFR decline. (
  • Research has shown that cancer patients in rural areas have lower survival rates than those in urban areas. (
  • This pilot study initiates a research program testing the early technical and clinical performance of a novel procedure for MRI-guided high-dose-rate (HDR) prostate brachytherapy. (
  • At the time this work was performed, both D.B.M. and X.W.W. were employees of and stockholders in Halozyme Therapeutics, a company that is engaged in research on an ultrafast-acting insulin with specific reference to rates of hypoglycemia. (
  • Study author Charles Stiller, from the University of Oxford's Childhood Cancer Research Group , said: "The results of our study show that improvements in childhood cancer survival match those reported by the relevant clinical trials that were running between 1978 and 2005. (
  • The European Commission this week announced a review of the European Clinical Trials Directive, a move "strongly welcomed" by a Cancer Research UK spokesperson. (
  • SCOTTSDALE, Ariz. - April 25, 2017 - Adding cisplatin to the standard gemcitabine/nab-paclitaxel drug treatment provided a very high rate of tumor shrinkage for patients with advanced pancreatic cancer, according to the results of a pilot clinical trial conducted by the HonorHealth Research Institute and the Translational Genomics Research Institute (TGen) . (
  • These statistically significant and clinically meaningful improvements in overall response and survival rates resulted from a phase Ib/II clinical study performed at the HonorHealth Research Institute, a partnership of HonorHealth and TGen. (
  • Connecting a global network of more than 40,000 cancer professionals, the society serves as the leading resource for best practices in clinical oncology research and academic and community practices. (
  • This pilot clinical trial began in 2013 through a partnership between the HonorHealth Research Institute and TGen. (
  • This precision medicine alliance enables both institutes to complement each other in research and patient care, with City of Hope providing a significant clinical setting to advance scientific discoveries made by TGen. (
  • Using biological markers-genetic characteristics that are associated with some patients with breast cancer-can increase the success rate of clinical trials for breast cancer drugs by almost 50 per cent, says new research from the University of Toronto Mississauga. (
  • The research team examined clinical trial drug development programs from 1998 to 2012 to determine how often breast cancer drugs were brought to market. (
  • Modification of Diet in Renal Disease Study Group and the Diabetes Control and Complications Trial Research Group. (
  • To run a successful trial that adequately answers the research question, a large collaborative team is required, particularly for definitive trials. (
  • It is commonplace for trials to hold meetings with site staff, such as the principal investigator and research nurse, who are responsible for recruitment of participants and data collection. (
  • Taking part in clinical research may not affect the insurance cover you get. (
  • Clinical trials are research studies that involve patients with mesothelioma. (
  • They can be sponsored by the National Cancer Institute, by Specialized Programs of Research Excellence or by Community Clinical Oncology Programs. (
  • 1 2 3 4 However, a large body of research found that between 25% and 50% of clinical trials remain unpublished, sometimes years after study completion. (
  • Charity Navigator, America's largest independent evaluator of charities, has awarded a four-star rating to the Diabetes Research Institute Foundation, the highest rating possible from this respected charity oversight organization. (
  • To view the Diabetes Research Institute Foundation's rating page, please visit the Charity Navigator website. (
  • The ICE-AFIB IDE trial is the first of its kind designed to assess the safety and sustained effectiveness of cryothermal ablation as a standalone energy source for surgical AF ablation," said Dr. Niv Ad, Director of Clinical Research at Washington Adventist Hospital and the national principal investigator of ICE-AFIB. (
  • LOS ANGELES , Feb. 6, 2019 /PRNewswire/ -- CytRx Corporation ( CYTR ), a biopharmaceutical research and development company specializing in oncology, highlighted positive Phase 2/3 clinical trial data from arimoclomol licensee Orphazyme A/S ( ORPHA.CO ). Orphazyme is currently developing arimoclomol in four different indications, including amyotrophic lateral sclerosis (ALS), Niemann-Pick disease Type C (NPC), Gaucher disease and sporadic Inclusion Body Myositis (sIBM). (
  • Our highly specialized Center includes leaders in the field who provide patients with the highest level of care in state-of-the-art facilities, perform basic scientific and clinical research, and offer the full spectrum of care including targeted therapies when appropriate, with the full range of support services from a top-ranked hospital and leading cancer center. (
  • With a closely integrated treatment center and clinical research center, we aim to develop new treatments and provide the highest quality care for people with diabetes, pre-diabetes, and associated disorders. (
  • Clinical research is a vital aspect of our mission. (
  • Our research not only gives current patients the opportunity to participate in clinical trials offering promising new treatments, but also aims to improve the lives of future generations of people with melanoma. (
  • We believe clinical research has a direct effect on clinical care, and our clinicians are actively involved in research. (
  • The authors urge international donors to foster the use of open-source database systems: 'Just as funders of biomedical research are starting to require scientific output to be published in open-access journals, could they not require that the software used for the management of clinical trials also be open? (
  • Clinical trials are research studies that aim to determine whether a medical strategy, treatment or device is safe for use or consumption by humans. (
  • A clinical trial research team may consist of doctors, nurses, social workers, health care professionals, scientists, data managers and clinical trial coordinators. (
  • The intention of clinical trials is predominantly one of research. (
  • Clinical trials on humans occur in the concluding stages of a long, systematic and thorough research process. (
  • In this week's webinar (hosted by the African Clinical Trials Consortium), Daniel Seymour from BIO Ventures for Global Health speaks about strategies for building needed research infrastructure for clinical trials. (
  • Provides cancer care for all ages and disease areas and supports clinical research and education. (
  • The focus of our research was on individual industry funded trials and therefore our suggestions for improving independence is mainly on trials. (
  • At University Hospitals Seidman Cancer Center, our head and neck cancer patients benefit from access to clinical trials and promising research. (
  • and (5) facilitation of special services to clinical research such as flexible randomization of patients, patient participation eligibility verification and double-blind trials. (
  • PARADIGMS is the first ever controlled, randomized trial specifically designed for pediatric MS. The results have been presented at the 7th Joint European and Americas Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS-ACTRIMS) meeting on October 28, 2017 in Paris, France. (
  • In addition to clinical care, this unique team of physicians and researchers is currently pursuing research in cancer immunotherapy, advanced tumor imaging, biomedical engineering of sarcoma-like substances and clinical trials - all dedicated toward improved patient-centered care. (
  • Looking forward the APGI is involved in global research associated with this trial based on investigating the biology of a patient's tumour to determine how individuals may respond to this treatment. (
  • The NIH said the DNA vaccine was brought "from the research bench into clinical trials in less than 6 months. (
  • Poor clinical trial designs result in failed studies wasting research funds and limiting the advancement of cures for disorders. (
  • This has drawn in research groups, biotechs, and pharma companies-all eager for clinical and financial success. (
  • Seminars hosted by Bridge Clinical Research to highlight the role that clinical research can play in minority health. (
  • If you or someone you know suffers from MS, you may be eligible to participate in a paid clinical research study. (
  • aims to bring together leading academic scientists, researchers and research scholars to exchange and share their experiences and research results on all aspects of Clinical Drug Development Process and Trial Design. (
  • Also, high quality research contributions describing original and unpublished results of conceptual, constructive, empirical, experimental, or theoretical work in all areas of Clinical Drug Development Process and Trial Design are cordially invited for presentation at the conference. (
  • FRIDAY, Aug. 17, 2018 (HealthDay News) -- Differences in survival rates between rural and urban cancer patients may be due to the kind of care they receive, a review of cancer clinical trials contends. (
  • We conducted a retrospective study of nine trials at the Nottingham Clinical Trials Unit (NCTU) that were open to recruitment between 2014 and 2018. (
  • SAN DIEGO and PENNINGTON, N.J., Nov. 7, 2018 /PRNewswire/ -- OncoSec Medical Incorporated (OncoSec) (NASDAQ:ONCS), a company developing intratumoral cancer immunotherapies, today announced that the first patient has been treated in KEYNOTE-890, a Phase 2 clinical trial for the treatment of late-stage triple negative breast cancer (TNBC) with TAVO™ (intratumoral plasma encoded IL-12, or tavokinogene telseplasmid, plus electroporation) in combination with Merck's KEYTRUDA® (pembrolizumab). (
  • Please download our Media Pack 2018 for all Print advertising rates. (
  • The American Diabetes Association (ADA) recently convened a working group to assess the impact of hypoglycemia and to provide guidance about how this information should be used in practice ( 1 ), but the methods used to assess hypoglycemia in clinical trials have received less attention. (
  • A comparison of statistical methods for combining event rates from clinical trials. (
  • We compare two statistical methods for combining event rates from several studies. (
  • In conclusion, by the use of standardized methods, an acceptable precision of GFR results can be obtained in multicenter trials. (
  • The same methods can be applied in clinical practice. (
  • Background: There have been different methods in clinical trials to quantify partial angiographic recanalization after mechanical thrombectomy for large vessel acute ischemic stroke. (
  • Methods: We reviewed clinical and angiographic data for consecutive patients who underwent mechanical thrombectomy at a single center. (
  • Methods Using the Aggregate Analysis of database and manual review, we identified all interventional clinical trials registered on with a primary completion date between October 2007 and September 2010 and with a lead investigator affiliated with an academic medical center. (
  • Methods We formed a task force of 22 participants comprising RCT experts, clinical epidemiologists and patient representatives. (
  • 24 June 2020 -- Full results from the positive Phase III ETHOS trial showed AstraZeneca's triple-combination therapy Breztri Aerosphere (budesonide/glycopyrronium/formoterol fumarate) demonstrated a statistically significant reduction in the rate of moderate or severe exacerbations compared with two dual-combination therapies in patients with moderate to very severe chronic obstructive pulmonary disease (COPD). (
  • Dublin, Sept. 14, 2020 (GLOBE NEWSWIRE) -- The "e-Clinical Trial Technologies - Global Market Trajectory & Analytics" report has been added to's offering. (
  • Amid the COVID-19 crisis, the global market for e-Clinical Trial Technologies estimated at US$5.4 Billion in the year 2020, is projected to reach a revised size of US$9.9 Billion by 2027, growing at a CAGR of 8.9% over the analysis period 2020-2027. (
  • The e-Clinical Trial Technologies market in the U. S. is estimated at US$1.6 Billion in the year 2020. (
  • ICCDDPTD 2020 has teamed up with the Special Journal Issue on Clinical Drug Development Process and Trial Design . (
  • Conclusions: TYA patients recruited to the clinical trial UKALL 2003 in England had a lower risk of mortality and a higher overall survival than contemporaneous non-trial patients. (
  • Conclusions Despite the ethical mandate and expressed values and mission of academic institutions, there is poor performance and noticeable variation in the dissemination of clinical trial results across leading academic medical centers. (
  • Many of the clinical trials for mesothelioma involve immunotherapy, which utilizes the body's own immune systems to fight off the cancer without all the toxic side effects of chemotherapy or radiation. (
  • Immunotherapy, the subject of many mesothelioma clinical trials, involves triggering a body's own immune system to fight off the disease instead of the toxic treatments like radiation and chemotherapy. (
  • KEYNOTE-890 is designed as a multicenter Phase 2 open-label trial focusing on patients with a histologically confirmed diagnosis of inoperable locally advanced or metastatic TNBC and at least 1 prior line of approved systemic chemotherapy or immunotherapy. (
  • Our trials include studies in cutting-edge immunotherapy, chemotherapy, vaccines, and novel targeted therapies to treat Stage III and IV melanoma. (
  • To understand the success rates of immunotherapy, it's important to differentiate between the different types available. (
  • The highly touted immunotherapy drug tremelimumab failed to extend the lives of malignant mesothelioma patients, according to the London-based manufacturer after it ended its multicenter clinical trial Monday. (
  • With the allowance for progression prior to response, we hypothesized that DRR is an appropriate measure of the ability of immunotherapy anticancer agents to mediate a clinically meaningful, sustained reduction in tumor burden that may be associated with measures of clinical benefit such as prolonged overall survival (OS), improved quality of life (QoL), and freedom from successive anticancer therapies. (
  • Researchers at Georgia Regents University Cancer Center are investigating a new avenue of treatment to help boost poor pancreatic cancer survival rates. (
  • Dr. Daniel Von Hoff, TGen Distinguished Professor and Physician-in-Chief who devised the clinical trial, agreed: "Although a small study, the high response rate and landmark evolving median survival are very encouraging, and this regimen is being expanded for patients with stage IV pancreatic cancer. (
  • The results of this trial are encouraging and deserve additional testing prior to becoming a standard of care for patients with advanced pancreatic cancer. (
  • Two clinical trials have been presented which will change the way doctors treat pancreatic cancer in the future- for the better. (
  • 2 studies were presented at the ASCO Meeting yesterday which showed drastic advances in survival rates for Pancreatic Cancer trial participants. (
  • This trial data suggests Pancreatic Cancer patients may benefit from this regime also. (
  • A primary outcome variable is the receipt rate of the full series of HPV vaccine among males and females aged 11-17 years. (
  • Using a step-wedge randomized controlled trial, we will design and test the effectiveness of multi-component primary care practice-based interventions on the completion of the HPV vaccine series and will explore implementation timing in high and low functioning practices to determine how specific characteristics affect the delivery of the full series. (
  • Intervention Cluster 1 is the first intervention arm designed to implement and test the effectiveness of a multi-component primary care practice-based intervention on initiation and completion of the HPV vaccine series as well as reduction in rates of missed opportunities to vaccinate. (
  • Phase 4 human clinical trial of anthrax vaccine adsorbed (AVA, BioThrax). (
  • Control and Prevention (CDC) Phase 4 human clinical trial of Currently, the Food and Drug Administration (FDA) Office of anthrax vaccine adsorbed (AVA, BioThrax). (
  • This clinical trial in Worcester, South Africa, is being conducted by the University of Cape Town's South African Tuberculosis Vaccine Initiative (SATVI), in partnership with Aeras, the clinical sponsor of the study, and the Wellcome Trust. (
  • We are pleased to complete the vaccination of our targeted 2,784 infants, which is the largest number of infants enrolled in any TB vaccine clinical trial. (
  • This Phase IIb clinical trial was initiated in July 2009 and involves a two-year follow up on the infants vaccinated as part of the trial to evaluate whether the vaccine candidate has conferred protection against TB. (
  • Overall, the Ebola vaccine trials displayed better coordination and cooperation among international researchers, regulators, manufacturers, funders, and the national authorities and communities of the Ebola affected countries than did the therapeutic trials. (
  • Most notably, while there was consensus that clinical trial data would be necessary in order to support the licensure of any investigational vaccine candidate, there was little agreement concerning the preferred specific design or execution of the trials. (
  • While determining the best designs for vaccine trials involved many of the same issues complicating the design of therapeutic trials-randomization, community perspectives, and access to potential benefit-the vaccine trials also posed distinct ethical issues. (
  • Jan 4, 2007 (CIDRAP News) - Federal officials have announced the launch of the first clinical trial of an H5N1 avian influenza vaccine made from a piece of the virus's DNA rather than from the whole virus, an approach that may facilitate faster vaccine production. (
  • If the vaccine performs well in trials and if the H5N1 virus evolves into a pandemic strain within the next couple of years, the vaccine could possibly be of some use in combating it, Nabel said. (
  • Nabel said another possibility is that the DNA vaccine, if it succeeds in clinical trials, could be used in combination with a traditional inactivated vaccine, assuming the traditional vaccine was at least modestly immunogenic. (
  • The federal government has a small stockpile of a traditional egg-based vaccine for H5N1, which has generated modest immune responses in trials. (
  • Westberg M, Frihagen F, Brun OC, Figved W, Grøgaard B, Valland H, Wangen H, Snorrason F. Effectiveness of gentamicin-containing collagen sponges for prevention of surgical site infection after hip arthroplasty: a multicenter randomized trial. (
  • To assess the utility and precision of GFR measurements in multicenter trials, the test performance and variability of GFR were analyzed in 2,250 patients enrolled in 44 clinical centers participating in either the Modification of Diet in Renal Disease (MDRD) Study or the Diabetes Control and Complications Trial (DCCT). (
  • The ICE-AFIB trial is a prospective, multicenter, single-arm study of up to 150 patients at up to 20 U.S. centers. (
  • The study looked at nearly 37,000 cancer patients from across the United States who took part in phase 2 or phase 3 clinical trials between 1986 and 2012. (
  • Arm 1 of the study will be coordinated and closely integrated with a separate concurrent study of MRI-guided prostate biopsy, which will be performed prior to accrual to Arm 1 of this trial (UHN 05-0641-C). In arm 2, patients with locally advanced prostate cancer will receive a boost of prostate-targeted HDR brachytherapy during external beam radiotherapy. (
  • Preliminary data acquired in this pilot study will determine the technical limits of MRI guided HDR brachytherapy and will be critical for the judicious conduct of a subsequent phase II clinical trial. (
  • Successful completion of this study will further individualize local therapy, not only for the benefit of the proportion of cancer patients for whom initial radiotherapeutic interventions have failed, but also provide valuable technical and clinical validation that these novel image-guided (IG) approaches are clinically feasible and could be applied more broadly in prostate cancer therapy. (
  • The results from this study will be presented during the Clinical Trials Session at the American Academy of Neurology 63rd Annual Meeting in Honolulu. (
  • In small populations (e.g., insulin pump users), a study comparing severe hypoglycemia outcomes is very challenging, even if the trial is enriched with high-risk subjects. (
  • The recent increase in survival for children with cancer is due to more patients taking part in clinical trials, according a British study. (
  • The study, published in the journal Annals of Oncology , found that the sharp increase was linked to the establishment of the UK Children's Cancer Study Group (UKCCSG - now the Children's Cancer and Leukaemia Group ) in 1977, which aimed to set up a portfolio of national and international trials for the majority of children's cancers. (
  • This study shows that the huge improvements in survival following cancers in childhood have come directly from the clinical trials that have been carried out," he said. (
  • The DerSimonian and Laird modified Cochran method (D&L) produces a weighted average of rate differences, where the weights allow for among-study variability. (
  • It was created because 95% of patients who respond to a trial recruitment advertisement do not qualify and/or enroll in that study. (
  • The pre-clinical study, which was conducted on swine over a two-week period, examined BloodSTOP iX Battle Matrix's effectiveness in stopping the bleeding using a standard military and FDA approved protocol: a 6mm arteriotomy made to the femoral artery using a vascular punch. (
  • The results of the pre-clinical study show promise in BloodSTOP iX Battle Matrix's capacity to save lives. (
  • Main outcome measures The proportion of trials that disseminated results, defined as publication or reporting of results on, overall and within 24 months of study completion. (
  • Overall, academic medical centers disseminated results for 2892 (66%) trials, with 1560 (35.9%) achieving this within 24 months of study completion. (
  • The proportion of clinical trials with results disseminated within 24 months of study completion ranged from 16.2% (6/37) to 55.3% (57/103) across academic medical centers. (
  • The proportion of clinical trials published within 24 months of study completion ranged from 10.8% (4/37) to 40.3% (31/77) across academic medical centers, whereas results reporting on ranged from 1.6% (2/122) to 40.7% (72/177). (
  • Ben-Neriah said he hoped the phase I clinical study will start in the US at the beginning of 2019. (
  • We were diligent in our design and implementation of a highly detailed animal toxicology study that specifically responded to the issues raised by the FDA to support the lifting of the partial clinical hold," said Jack Barber, Ph.D., CytRx's Chief Scientific Officer. (
  • In February 2009, CytRx announced the commencement of a Phase 2/3 adaptive clinical trial, sponsored by the ALS Association and the FDA's Office of Orphan Products Development OOPD, to study arimoclomol in a subset of patients with the inherited or familial form of ALS. (
  • Assessment of the integrity of study blindness in a pediatric clinical trial of risperidone. (
  • This is a study of the effectiveness of rater blinding, rather than of the clinical effectiveness of risperidone. (
  • Designs of clinical trials can be either "observational" or "experimental" and include study types including cohort, case control, systematic review and randomized controlled trials. (
  • A phase II study, presented at the 2015 ASCO Annual Meeting (MDV3100-11 trial), evaluated single-agent Xtandi (enzalutamide) - an AR inhibitor that impairs nuclear localization of AR - in patients with advanced AR-positive (IHC ≥10 percent and ≥1 post-baseline tumor assessment) TNBC. (
  • Thus far, this study is the largest prospective trial to date of an AR inhibitor in TNBC. (
  • Dr VanderWalde reports, through a study carried out with the Alliance for Clinical Trials in Oncology, that one interesting finding was that as the modalities in trials increase, the more difficult it is to accrue older adults. (
  • The results came from a Phase II study that compared two doses of dulaglutide to placebo, using ambulatory blood pressure monitoring (ABPM) to characterize changes in blood pressure and heart rate. (
  • This study used the gold standard measurement technique of ABPM to evaluate the blood pressure and heart rate effects of dulaglutide, an investigational GLP-1 receptor agonist. (
  • The study also had several secondary objectives, including effects on mean 24-hour diastolic blood pressure (DBP, or pressure when the heart relaxes between beats) and mean 24-hour heart rate. (
  • The study suggests that administering a sequential estrogen and progesterone supplementation regimen, including Prochieve eight percent, with clomiphene citrate cycles in oligo-ovulatory and anovulatory women could more than double the rate of pregnancy, as compared to clomiphene citrate therapy alone. (
  • First, in a study of 4,530 people studied on average of 3 years with a history of high blood pressure, men were 218% more likely to die if their heart rate was elevated and women were 214% more likely to die. (
  • In a study of people with a prior heart attack or heart failure history , for every heart rate increase of 5 bpm there was an 8% increase in death, 16% increase in worsening heart failure required hospitalization, and a 7% increased risk of heart attack. (
  • 3. The method of claim 2 wherein the meta-data or performance metrics correspond to the performance of a clinical site, clinical personnel or study parameters. (
  • As part of the study information provided, and as a possible incentive to take part, potential participants were made aware that the combined treatment had been associated with a significant reduction in the rate of hospital admissions in the pilot study. (
  • PRINCETON, N.J. & TOKYO--( BUSINESS WIRE )-- Bristol-Myers Squibb Company (NYSE:BMY) and Otsuka Pharmaceutical Co., Ltd. today announced Phase III study results in which SPRYCEL (dasatinib) 100 mg once daily demonstrated a superior rate of confirmed complete cytogenetic response(CCyR) † compared to Gleevec ® (imatinib mesylate). (
  • In this study, SPRYCEL 100 mg once daily demonstrated rates of overall adverse events and discontinuations comparable to Gleevec. (
  • Overall rates of fluid retention observed in the study were 19% with SPRYCEL and 42% with Gleevec. (
  • DASISION (Dasatinib versus Imatinib Study in Treatment-Naïve CML Patients) is an open-label, randomized, Phase 3 international trial of SPRYCEL 100 mg taken once daily with no food restrictions vs. Gleevec 400 mg taken once daily, in the treatment of newly diagnosed chronic phase CML. (
  • Instead of less than 10% of drugs reaching the market, a new study has found that almost 15% of new compounds pass clinical trial-which still suggests that it's pretty daunting. (
  • A study carried out by King's College London and the London School of Economics found that the majority of EMA-approved cancer drugs had not improved survival or quality of life during clinical trials. (
  • The re-randomization design can be used in situations where (1) patients may require treatment on multiple occasions, (2) the intervention(s) under study would be used for each new treatment episode, and (3) the intervention duration and length of the follow-up period for each randomization are less than the overall length of the trial recruitment period. (
  • however, no prospective criteria are designated for interpreting the clinical relevance of this information at the patient level or for treatment effect in a controlled study. (
  • The largest study to date on ethnic minority gay men and men who have sex with men (MSM) in the UK has found significant variations in rates of HIV infection between ethnic groups despite similar rates of sexual risk behaviour. (
  • Participants Academic medical centers with 40 or more completed interventional trials registered on (
  • Results We identified 4347 interventional clinical trials across 51 academic medical centers. (
  • The results were presented during the 2017 Gastrointestinal Cancers Symposium, sponsored by the American Society of Clinical Oncology, in San Francisco. (
  • Participants: 511 patients aged 15-24 years diagnosed with ALL between 2004 and 2010 inclusive, of whom 239 (46.7%) participated in the UKALL2003 trial. (
  • For the 60 attending sites, recruitment increased from 254 participants prior to the meeting to 271 post meeting, giving a 0.100 (− 0.160, 0.360) mean change in weekly recruitment per site, providing no evidence that recruitment rates increase following an investigator meeting. (
  • Participants must read and sign the "informed consent" document before inclusion in a trial. (
  • Risks to clinical trial participants are controlled and monitored. (
  • The majority of potentially eligible participants declined participation in the trial after reading the information sheet. (
  • Poor recruitment can also lead to concerns regarding the ethics of exposing participants to the potential harms of taking part in the trial and then failing to use their contribution if recruitment proves infeasible. (
  • Gul, R.B. & Ali, P.A. Clinical trials: the challenge of recruitment and retention of participants. (
  • Now, researchers are turning to combination therapies to improve these rates, coupling chemotherapy with drugs that enhance the immune system's ability to fight cancer. (
  • This is why our cancer center is taking a leading role in advancing clinical trials examining the effectiveness of combination therapies-which are increasingly being recognized as a promising new avenue of treatment for cancer. (
  • Participation of patients with mesothelioma in clinical trials is essential if we are going to make progress and develop novel therapies," said Raffit Hassan, M.D., a senior investigator at the National Cancer Institute. (
  • These clinical trials help doctors measure the effectiveness, and get a better picture, of new therapies. (
  • Phase II cancer clinical trials are designed to identify the spectrum of antitumor activity of new therapies using the dose and schedule identified in phase I trials ( 2 ). (
  • The dual-combination therapies used as comparators in the trial represent recommended therapeutic classes for the treatment of COPD. (
  • The results of the Phase III ETHOS trial support the strong clinical profile of Breztri Aerosphere in reducing exacerbation rates compared with dual-combination therapies. (
  • Clinical researchers dedicate themselves to investigating new drugs, biological therapies and cancer growth blockers, including novel compounds to prevent progressive tumor growth in aggressive oral cancers. (
  • The application of these results to future studies may provide a standard definition of clinically important improvement in clinical trials of chronic pain therapies. (
  • This trial will strive to demonstrate improvements in technical performance under MRI-guidance, while exploring a novel paradigm of patient-specific modulation of dose intensity based on regions of tumor burden. (
  • After just three treatment cycles, we saw tumor markers plummet and some patients' tumors shrink significantly in just nine weeks," said Gayle Jameson, nurse practitioner and principal investigator of the clinical trial, who is highly encouraged by the response. (
  • Principles and Practice of Clinical Trial Medicine. (
  • Whilst the importance of clinical trials in informing best practice is well established, data regarding individual patient benefit are scarce. (
  • A commonly used communication tool is the hosting of an investigator/collaborator meeting, which offers an opportunity for sites to re-train and receive trial updates, learn from each other, share best practice and troubleshoot issues. (
  • They offer an opportunity for sites to re-train, network and be part of the trial community and to share good practice or troubleshoot issues with other sites and the coordinating centre. (
  • As pointed out in the editorial by Pulst and in the Practice Point commentary by Subramony in the March issue of Nature Clinical Practice Neurology , scales recently developed for the assessment of spinocerebellar ataxias (SCAs) do not include items on extracerebellar deficits. (
  • Studying clinical trial relationships through Good Clinical Practice (GCP) assignments of roles and responsibilities is certainly a possibility, but that would be investigating an entirely different aspect of the clinical trials. (
  • The book examines information on high placebo response, the generalizability of studies conducted in the developing world, the duration of maintenance studies, and the application of findings into clinical practice. (
  • Impaired results of a randomised double blinded clinical trial of propranolol versus placebo on the expansion rate of small abdominal aortic aneury. (
  • The hypothesis is that vitamin D supplementation results in significant improvement in the ovulation rate of women with PCOS either spontaneously or with oral ovulation induction agent. (
  • To evaluate performance of CATE designs, extensive simulation studies had been conducted and the results shows that CATE designs outperform the existing designs for phase I cancer clinical trials. (
  • You may need to answer questions about the results of tests you have had, or details of tests you are going to have, as part of the trial. (
  • Insurers will not ask you about any results for genetic tests you have during a clinical trial. (
  • Objective To determine rates of publication and reporting of results within two years for all completed clinical trials registered in across leading academic medical centers in the United States. (
  • Dissemination is principally achieved through publication in peer reviewed biomedical journals as well as through public reporting of results on clinical trial registries. (
  • Results from recently completed clinical studies of TAVO™ have demonstrated a local immune response, and subsequently, a systemic effect as either a monotherapy or combination treatment approach. (
  • Following the disastrous results of the experimental trials, researchers began investigating whether current fluoride exposures in the population could pose a similar risk. (
  • In March 2009, the Company reported that arimoclomol had demonstrated statistically significant neurorestorative results in a preclinical embolic stroke trial. (
  • The results were published in the New England Journal of Medicine1 and simultaneously presented at the American Thoracic Society virtual Scientific Symposium, Clinical Trial Results in Pulmonary Medicine. (
  • Klaus Rabe, Professor of Pulmonary Medicine at the University of Kiel, Director of the Department of Pneumology at Clinic Grosshansdorf, Germany, and Lead Investigator of the ETHOS trial, said: "The Phase III ETHOS trial results are important and demonstrate the benefit of Breztri Aerosphere in reducing the rate of exacerbations in this progressive disease. (
  • We are very encouraged by these clinical trial results, in addition to the rest of the clinical trial data we've seen to date for dulaglutide," said Gwen Krivi, Ph.D., vice president, product development, Lilly Diabetes. (
  • 2 To address this challenge and ensure that clinical development efforts render meaningful results, there is a need to develop outcome measures that assess the entire characteristic clinical phenotype of any given rare genetic condition. (
  • Clinical Trial Design Challenges in Mood Disorders outlines classic problems researchers face in designing clinical trials and discusses how best to address them for the most definitive and generalizable results. (
  • The above paper helped clarify for me the current status of clinical trial test results, and boy was it an eye-opener. (
  • Furthermore, longer recruitment periods will delay trial results being known, leading to delays in successful interventions being adopted into routine care, or in unsuccessful or harmful treatments being discontinued. (
  • We suggest that a numerical cut point approach, applied in the appropriate treatment population, is a valid and meaningful alternative to severe hypoglycemia rate determination for comparing hypoglycemia risk between diabetes treatments. (
  • Clinical trials often provide the best chance of survival for a patient with malignant mesothelioma , offering access to the latest, cutting-edge treatments at a leading specialty center. (
  • Trials evaluating treatments for neglected diseases are hampered by a shortage of software systems that manage data in compliance with international guidelines, say Greg W. Fegan and Trudie A. Lang in PLoS Medicine . (
  • Clinical drug trials are divided into 4 phases to examine the safety of a new drug and compare it to existing treatments. (
  • This meta-analysis sought to assess the effectiveness of the different treatments for WM tested in published trials using the response rate (RR) as the main outcome measure. (
  • Dana-Farber/Brigham and Women's Cancer Center offers a number of melanoma clinical trials . (
  • We aim to provide a broad range of options for high-risk melanoma patients or patients with metastatic disease, so that patients can be matched in trials that best fit their needs. (
  • This is a randomized double-blind controlled trial on the effect of vitamin D supplementation to assess the ovulation rate of women with polycystic ovary syndrome (PCOS) and other reproductive, endocrine and metabolic outcomes after one year of treatment. (
  • We analyzed the outcomes of single-agent phase II clinical trials in non-small cell lung cancer (NSCLC) to determine trial parameters that predicted clinical activity. (
  • However, larger adequately powered RCTs are required to define the clinical effect of ulinastatin on postoperative outcomes in cardiac surgery. (
  • Although ulinastatin has been tested in many small sample sized clinical trials in cardiac surgery since the 1990s, where it has demonstrated the clear inhibitory effects in attenuating the postoperative increase in proinflammatory cytokines, its impact on clinical outcomes and postoperative complications remains controversial [ 9 - 15 ]. (
  • We therefore undertook a systematic review and meta-analysis of randomized controlled trials (RCTs) which analyzed the effects of intraoperative ulinastatin treatment on postoperative clinical outcomes in patients undergoing cardiac surgery. (
  • That may be due to a number of factors, such as timely access to follow-up chemotherapy after their first round of cancer treatment, according to the researchers, who are with SWOG, the international cancer clinical trials network funded by the U.S. National Cancer Institute. (
  • Within the field of clinical trials, rating is the process by which a human evaluator subjectively judges the response of a patient to a medical treatment. (
  • The rating can include more than one treatment response. (
  • Imagine you have breast cancer and, after standard treatment fails, your physician recommends you join a clinical trial which tests experimental medicines. (
  • He said that although trends in childhood cancer survival had been reported in relation to improvements in treatment in the UK, this was the first time that population-based survival had been looked at in relation to available clinical trials at the time. (
  • Based on the observed 2-year mortality rate, a total of 508 events would be required to detect a significant treatment benefit in a two-arm trial with 90% power to detect a 25% reduction in all-cause mortality. (
  • A combined analysis of clinical trials evaluating etanercept and infliximab in the treatment of AS demonstrated that both drugs significantly reduced uveitis flare rates compared with placebo (p = 0.05). (
  • You shouldn't have any problem getting cover if you are a healthy volunteer in a trial and are not having tests or treatment. (
  • A Phase II trial takes a closer look at safety and dosage levels, but now is looking to see how effective the treatment or drug will be. (
  • A Phase III trial precisely measures the effectiveness of the treatment when compared to the traditional approach. (
  • AtriCure, Inc. ( ATRC ), a leading innovator in surgical treatment for atrial fibrillation (Afib) and left atrial appendage management, today announced the first patient was treated in the ICE-AFIB™ trial (NCT03732794). (
  • In the predefined subgroup of patients of 4 years and older (44 out of 50 randomized patients in the trial), the treatment difference was statistically significant with a minimal disease progression at month 12 in the arimoclomol-treated group (p-value =0.0219). (
  • A highly statistically significant treatment difference was observed in another predefined subgroup analysis, requested by the EMA, that compared arimoclomol to placebo control in patients receiving miglustat as a part of routine clinical care (p-value =0.0071). (
  • The Mass General Diabetes Clinical Center is one of the oldest outpatient centers in the country dedicated to the comprehensive treatment of persons with diabetes, pre-diabetes, and associated disorders. (
  • Instead of reducing the number of fractures, however, numerous clinical trials reported that the fluoride treatment increased the rate of fractures (particularly hip fractures) and caused a number of other side effects, including gastric distress and joint pain. (
  • Animal trials have shown that the treatment showed major improvements in regards to "pulmonary hypertension, lung fibrosis, acute kidney injury and gastrointestinal injury," according to the Post. (
  • Clinical trials are designed to add to medical knowledge related to the treatment, diagnosis and prevention of diseases or conditions. (
  • This website is an index of educational and reference material concerning clinical trials including links to fact sheets, basic facts about clinical trials, guides to finding a cancer treatment trial,and patient protection information. (
  • Overall survival rates don't identify whether or not survivors are in remission or still undergoing treatment after five years. (
  • Breast cancer clinical trials test the safety and effectiveness of new treatment approaches. (
  • Use of a systematic scale in assessment of clinical response can provide broader and more accurate insights that could lead to more targeted and effective treatment decisions. (
  • The mesothelioma program at the Moffitt Cancer Center in Tampa opened two new clinical trials recently, expanding efforts to provide patients throughout the state with more treatment options. (
  • The invention is of particular relevance to adaptive clinical trials and other applications that demand the ability to quickly collect, process, and respond to various forms of data in order to adjust actions such as randomization schedules, interim analyses, treatment arm pruning, editing subpopulations, and other adaptive measures. (
  • Current treatment guidelines state that achieving a complete cytogenetic response rate by 12 months is important because data suggest that there is an increased risk of disease progression in CML patients who do not attain this treatment goal," said Hagop Kantarjian, MD, Chairman and Professor, Leukemia Department, The University of Texas MD Anderson Cancer Center, and lead author of the New England Journal of Medicine paper. (
  • Re-randomization can increase recruitment most for trials with a short follow-up period, a long trial recruitment duration, and patients with high rates of treatment episodes. (
  • He is the originator of response expectancy theory, and his analyses of clinical trials of antidepressants have influenced official treatment guidelines in the United Kingdom. (
  • In placebo-controlled trials, the uveitis rate per 100 subject years (95% CI) for etanercept (8.6 (4.5 to 14.2)) was lower than that for placebo (19.3 (11.0 to 29.8), p = 0.03). (
  • The long-term rate for etanercept, estimated from both placebo-controlled and open-label extension studies was 12.0 (10.0 to 14.1). (
  • In subjects with AS, rates of uveitis events with etanercept were lower than with placebo in placebo-controlled trials and similar to sulfasalazine in an active comparator trial. (
  • Data on 2724 subjects from 10 recently completed placebo-controlled clinical trials of pregabalin in diabetic neuropathy, postherpetic neuralgia, chronic low back pain, fibromyalgia, and osteoarthritis were used. (
  • Randomised placebo-controlled trial of effect of ramipril on decline in glomerular filtration rate and risk of terminal renal failure in proteinuric, non-diabetic nephropathy. (
  • Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. (
  • An experimental drug developed by Teva Pharmaceutical Industries has been found in clinical studies to reduce MS relapse rate by 23% over a placebo, bringing hope to many patients. (
  • These are all questions that cannot currently be answered because there is a sharp asymmetry of information between those running and funding these studies and those participating in the trials," said Chance O. Curtis , CEO and Co-Founder of (
  • Between-group differences with confidence intervals (CIs) in the uveitis rates were calculated for the double-blind, active-controlled and long-term studies. (
  • The studies used similar protocols for obtaining blood and urine, training clinical center staff, and processing specimens in central laboratories. (
  • Objectives Our initiative aimed to produce recommendations on post-randomised controlled trial (RCT) trial extension studies (TES) reporting using European League Against Rheumatism (EULAR) standard operating procedures in order to achieve more meaningful output and standardisation of reports. (
  • The rights to the molecule they developed has already been sold by the technology transfer arm of the Hebrew University, Yissum, to US pharma firm BioTheryX , with whom the team of researchers will continue to work to further develop the medication and apply for FDA approval for phase I clinical studies on humans. (
  • More recently, studies of human populations have reported increased fracture rates in communities with 4 mg/L fluoride in the water, and animal studies have consistently found reductions in bone strength from fluoride exposures. (
  • Consistent with the clinical trials, numerous animal and in vitro studies have reported that bone strength declines with increased fluoride exposure. (
  • Two consistent findings from these studies emerged: fluoride levels in drinking water (4 mg/L) that are still considered " safe " by the EPA reduce the density of cortical bone and increase the bone fracture rate in a population. (
  • Most of the studies, for example, only examined older populations that had no exposure to fluoridated water during their childhood (the period of life with the highest rate of fluoride accumulation in bone). (
  • However, some studies have found lower rates of success in people treated with this drug. (
  • Again, we emphasize that the FDA's partial clinical hold was unrelated to data generated by human studies and arimoclomol has been studied in seven Phase 1 and two Phase 2 clinical trials without any significant adverse events. (
  • The suicide rate goes up in spring and summer-not winter as many believe-and studies suggest a link between immune-system inflammation from pollen and seasonal depression. (
  • However, this was one of the first studies to suggest that elevated heart rate alone may be an important long-term marker of risk. (
  • With these two studies we have learned that an elevated heart rate in heart disease or with a risk factor for heart disease (high blood pressure) is a bad sign. (
  • Use of a standard outcome across chronic pain studies would greatly enhance the comparability, validity, and clinical applicability of these studies. (
  • The group at MIT defined key characteristics, including whether a compound was undergoing Phase 1, 2, or 3 clinical trials so that a diverse range of studies could be analyzed. (
  • The feasibility of using mobile health applications to conduct observational clinical studies requires rigorous validation. (
  • The purpose of the trial is to evaluate the effectiveness of adding the anti-angiogenesis monoclonal antibody bevacizumab (Avastin) to a standard chemotherapy regimen to fight head and neck cancers. (
  • UH Seidman Cancer Center clinical researchers have found that patients with anaplastic thyroid carcinoma and a low level of the biomarker intercellular adhesion molecule 1 (ICAM1) have a better chance of survival and an increased response to chemotherapy. (
  • The second trial- treating patients with chemotherapy and radiotherapy first, surgery second. (
  • In the five years after enrollment in the trials, there was no significant difference in survival rates between rural and urban patients for all of the types of cancer except one. (
  • In 2012, ePharmaSolutions, developer of ReferralPlus, organized more than 30 major pharmaceutical companies and CROs to participate in the pilots to determine if they could help increase enrollment rates by triaging/matching patients who disqualified from one clinical trial to trials listed by other participating sponsors. (
  • A method and system are described for centrally managing data in an adaptive clinical trial or other adaptive process that is conducted at a plurality of geographically remote sites. (
  • To assess uveitis (including iritis and iridocyclitis) incidence from clinical trials of etanercept in patients with ankylosing spondylitis (AS). (
  • Clinical Trials, an essential part of drug discovery process, assess the safety and effectiveness of a new medication or device in the pharmaceutical industry. (
  • Professor Chad Heatwole at the University of Rochester was among the first to develop a rating scale or index to assess therapeutic change in DM1. (
  • In Verily's Letter of Intent the new feature was seeking to assess Parkinson's disease symptoms in clinical trials. (
  • For example, cancer death rates between 2011 and 2015 were 180 per 100,000 people in rural areas and 158 per 100,000 people in urban areas, according to the U.S. Centers for Disease Control and Prevention. (
  • Dr Noam VanderWalde speaks to ecancer at the SIOG 2019 meeting in Geneva about the need for accruing older patients in clinical trials. (
  • According to Parker, some researchers have hypothesized that in the era of personalized medicine, biological markers, or biomarkers, could be used to improve clinical trial success rates and help bring more drugs to market faster. (
  • When questions arise in the clinic, clinician-researchers can answer them through clinical trials, and take the new knowledge back to the clinic where it can benefit patients. (
  • Researchers at the Hebrew University of Jerusalem said they have developed a new biological drug that had a 50 percent cure rate for lab mice with acute leukemia. (
  • Clinical trials help keep our cancer care on the leading edge by allowing researchers to apply cancer knowledge as it develops to give you the best chance of survival. (
  • Researchers in clinical psychology and psychiatry. (
  • In addition to a reduction in relapse rate, laquinimod was also associated with a 36% reduction in disability progression compared with placebo. (
  • This can means millions of dollars in cost reduction for a clinical trial," says Parker. (
  • Realizing high-rate sulfur reduction under sulfate-rich conditions in a biological sulfide production system to treat metal-laden wastewater deficient in organic matter. (
  • In chronic nephropathies with proteinuria of 3 g or more per 24 h, ramipril safely reduces proteinuria and the rate of GFR decline to an extent that seems to exceed the reduction expected for the degree of blood-pressure lowering. (
  • Subramony SH (2007) SARA-a new clinical scale for the assessment and rating of ataxia. (
  • The recently developed Scale for the Assessment and Rating of Ataxia (SARA) has an α value of 0.94. (
  • To conduct a comprehensive evaluation of mortality in three phase 3 clinical trials and evaluate the feasibility of mortality trials in patients with IPF. (
  • The drug is currently being explored in the phase III ENDEAR trial, which will evaluate Xtandi in combination with paclitaxel or as a monotherapy versus placebo with paclitaxel in patients with locally advanced or metastatic TNBC. (
  • Includes publications given by the data provider as well as publications identified by Identifier (NCT Number) in Medline. (
  • A trial design that uses a numerical cut point to define hypoglycemia must pay rigorous attention to data acquisition methodology. (
  • Outcome measures: Patients were identified using National Clinical Trial (UKALL2003) and Cancer Registry (National Cancer Data Repository, English National Cancer Online Registration Environment) Databases. (
  • These data underline the potential for individual patient benefit in participating in a clinical trial and the importance of international efforts to increase trial participation in the TYA age group. (
  • Trials might have to suspend accrual to obtain complete data and lead to long trial durations and complicate administrative burdens. (
  • Using meeting attendance data available in Trial Master Files (TMF) and recruitment data from randomisation datasets, we examined recruitment rates in the 8 weeks prior to and following the date of the investigator meeting. (
  • Such meetings can be held during the recruitment and data-collection phase of a trial, and are often repeated intermittently for the duration of a trial. (
  • Orphazyme announced the full data set for its Phase 2/3 trial evaluating arimoclomol in patients with NPC. (
  • We commend the Orphazyme team for the impressive data from their Phase 2/3 clinical trial in NPC and believe the significant value of this important asset is just now beginning to be unlocked. (
  • Data on response rate (RR), progression-free survival (PFS), and overall survival (OS) from all English language, single-agent phase II trials in advanced/metastatic NSCLC indexed by PubMed (January 2000 through December 2009) were abstracted. (
  • Data from a 10,000-patient trial showed that people with osteoarthritis taking Novartis' Ilaris had 40% to 47% lower rates of joint replacements. (
  • They argue that the prohibitive cost of clinical trials-related software leaves many developing country institutions with the unenviable choice of either not being able to comply with international standards or having to send trial data offsite for processing. (
  • Clinical trials provide the most reliable data to assist in health care decision-making and guidelines. (
  • Five-year survival rates are based on data from hundreds or thousands of patients of all ages and health conditions with a specific cancer, explains Mayo Clinic. (
  • These data were presented during a late-breaking clinical trial session at the 2012 Annual Scientific Meeting of the American Society of Hypertension (ASH) in New York. (
  • and (e) providing instructions, based on the reported data, to (i) correct the data, or (ii) follow or modify the procedures or parameters utilized in conducting said clinical trial or other process. (
  • 2. The method of claim 1 wherein the data comprise meta-data or performance metrics with respect to said clinical trial or other process. (
  • 4. The method of claim 3 wherein the meta-data or performance metrics comprise a measurement of: error rates, time required to respond to errors or to data queries returned to a site, number of patients screened, number of patients enrolled, or length of time required to transmit data following a patient visit. (
  • State-specific data indicated that the highest rates of pediatric ALL incidence were in California, New Mexico, and Vermont. (
  • Chief Investigator has requested that the full data set be removed while the trial is awaiting publication for reasons of confidentiality. (
  • Potential challenges with this technology include selection bias, low retention rates, reporting bias, and data security. (
  • The controversy surrounding this analysis led Kirsch to obtain files from the U.S. Food and Drug Administration (FDA) containing data from trials that had not been published, as well as those data from published trials. (
  • Analyses of the FDA data showed the average size effect of antidepressant drugs to be equal to 0.32, clinically insignificant according to the National Institute for Health and Clinical Excellence (NICE) 2004 guidelines, requiring Cohen's d to be no less than 0.50. (
  • In the trial, the most frequently reported adverse events were nasopharyngitis, COPD and upper respiratory tract infection. (
  • The safety profile of Gilenya was overall consistent with that seen in previous clinical trials, with more adverse events reported in the interferon group[1]. (
  • The systematic meta-analysis of randomized controlled trials (RCTs) evaluated the effects of intraoperative ulinastatin on early-postoperative recovery in patients undergoing cardiac surgery. (
  • Many of the arguments against randomized controlled trials (RCTs) for Ebola therapeutics centered on the ethics of giving an infected person a placebo or only standard of care when the risk of death was so high without an effective intervention. (
  • Objective: Participation rates in clinical trials are low in teenagers and young adults (TYA) with cancer. (
  • The primary endpoints included hospital mortality, postoperative complication rate, length of stay in intensive care unit, and extubation time. (
  • There has not, however, been validation that DRR correlates with other more traditional endpoints of clinical benefit such as overall survival. (
  • trials as well as easy access to participate in clinical trials, has begun operations. (
  • Conversely, the use of outcome measures that focus on only a limited subset of the signs and symptoms of a condition like congenital DM1 may confer a lower chance of success in identifying benefit in intervention trials or may inadvertently convey an impression of limited utility and therapeutic attractiveness. (
  • For patients with locally advanced disease, our physicians are engaged in a Phase II clinical trial of the epidermal growth factor receptor tyrosine kinase inhibitor erlotinib (Tarceva) in combination with docetaxel administered concurrently with radiation. (
  • Are survival and mortality rates associated with recruitment to clinical trials in teenage and young adult patients with acute lymphoblastic leukaemia? (
  • We have investigated the association between overall survival and trial recruitment in TYA patients with acute lymphoblastic leukaemia (ALL). (
  • We considered three clinical areas: in vitro fertilization, severe asthma exacerbations, and acute sickle cell pain crises. (
  • The Jerusalem Post reported that the company plans to apply to multiple nations to begin clinical trials for complications associated with Cornavirus symptoms. (
  • All-cause mortality rate in patients with idiopathic pulmonary fibrosis. (
  • The all-cause mortality rate was 6.6% at 1 year and 13.7% at 2 years. (
  • The all-cause mortality rate is relatively low in patients with IPF with mild to moderate impairment in lung function. (
  • Although the mortality rate from cancer has declined , it remains one of the biggest causes of death in the world. (
  • In large, multi-centre trials, communication between the coordinating centre and trial sites is essential. (
  • In this trial, what I think was surprising was that the effect on disability is larger than the effect on relapses," said Dr. Giancarlo Comi, director of the Department of Neurology and Institute of Experimental Neurology at the Scientific Institute and University Vita-Salute San Raffaele in Milan. (
  • Do investigator meetings improve recruitment rates in clinical trials? (
  • Poor recruitment in clinical trials is well-documented. (
  • Anecdotally, there is a perception that recruitment rates may increase after holding such a meeting. (
  • Thus, if the meeting has been held in the belief that it will have a positive impact upon recruitment, trialists may wish to consider other evidence-based strategies known to increase recruitment rates. (
  • It is important to ensure continued communication with trial sites throughout and, although there has been no formal evaluation, it is thought that good communication with sites could have an effect upon trial recruitment [ 2 , 3 ]. (
  • In some circumstances, the meetings may be held in response to trial-specific issues, such as poor recruitment. (
  • Patient recruitment in clinical trials is often challenging, and as a result, many trials are stopped early due to insufficient recruitment. (
  • Because it allows multiple enrollments for each patient, this design has been proposed as a way to increase the recruitment rate in clinical trials. (
  • We modelled the expected recruitment rate for parallel-group and re-randomization trials in different settings based on estimates from real trials and datasets. (
  • Re-randomization has the potential to increase the recruitment rate in certain settings, and could lead to quicker and more efficient trials in these scenarios. (
  • Longer recruitment periods are also problematic, as they lead to higher costs, allowing fewer trials overall to be funded. (
  • To participate in a clinical trial, possible subjects have to meet eligibility criteria which define who is suitable to take part. (
  • Two-year lasting prospective randomised double-blinded intervention trial. (
  • Prospective non-randomised clinical assay (n = 158). (
  • Our objective is to monitor glomerular filtration rate (GFR)during the perioperative phase of patients undergoing robotic surgery for rectum or large bowel cancers. (
  • Accurate, direct measurements of glomerular filtration rate (GFR) may provide a tool to monitor perioperative onset of rapidly changing renal function. (
  • Glomerular filtration rate measurements in clinical trials. (
  • In diabetic nephropathy, angiotensin-converting-enzyme (ACE) inhibitors have a greater effect than other antihypertensive drugs on proteinuria and the progressive decline in glomerular filtration rate (GFR). (
  • Currently, there are approximately 1.1 million patients enrolled in clinical trials in the United States. (
  • Unfortunately, from the clinical trial perspective, it is relatively rare, occurring at a rate of about 13.5 episodes per 100 patient-years in type 1 diabetes trials ( 2 ). (
  • Joining a clinical trial might be the most important step any cancer patient can take - a leap of faith that goes well beyond one's own best interests. (
  • Each phase, and each trial, has a list of qualifications that must be met before a patient is accepted. (
  • Treating the first patient in our KEYNOTE-890 clinical trial is an important milestone for OncoSec as we seek to rapidly advance this program," said Kellie Malloy Foerter, Chief Clinical Development Officer of OncoSec. (
  • The Diabetes Clinical Center currently handles approximately 10,000 patient visits per year. (
  • There are also sections of the website which include links pertaining to Educational Materials for becoming a clinical trial investigator, Patient Care Costs, Special Topics, and NCI Programs That Conduct Clinical Trials. (
  • But no doubt the oncology and patient community will be united in the thinking that any improvement to survival rates is a major step forward in this disease. (
  • This can allow for an array of differences in rating. (
  • A review of cancer clinical trials contends that the differences in survival rates between rural and urban cancer patients may be due to the kind of care they receive. (
  • Relative survival rates were calculated for trial and non-trial patients and observed differences were modelled using a multiple regression approach. (
  • Most of the time the differences in peoples resting heart rates are not so extreme. (
  • Until recently, the use of CAR T-cell therapy has been restricted to small clinical trials, largely in patients with advanced blood cancers. (
  • By having an easy-to-use interface, those looking for a clinical trial can search based on disease as well as geographic area. (