OrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaTechnology, Industry, AgricultureInformation ScienceNamed GroupsHealth CareGeographicals
Breakthrough PainInsulin, Short-ActingAdministration, BuccalFentanylLabor PainTreatment OutcomeAnalgesics, OpioidFourier AnalysisCommunicable Disease ControlEducation, GraduateIcelandEpidemiologyCommunicable DiseasesNight CareComparative Effectiveness ResearchMatched-Pair AnalysisUnited States Agency for Healthcare Research and QualityUnited StatesAmerican Recovery and Reinvestment ActRandomized Controlled Trials as TopicSan FranciscoDrug IndustryChamaecristaSoftwareDrug DiscoveryInternetDrug RepositioningCarnivoraMathematicsEnglandUniversitiesLegal GuardiansMathematical ConceptsGreat BritainInvestmentsJournal Impact FactorMarketingModels, EconomicCommerceFinancial ManagementEnergy-Generating ResourcesCritical IllnessClinical Trials as TopicCritical CarePolyneuropathiesWounds and InjuriesIntensive Care UnitsResearch Support as TopicAlzheimer DiseaseCongresses as TopicPharmacopoeias as TopicMental Health AssociationsInternational CooperationAmyloid beta-PeptidesUnited States Food and Drug Administration
Breakthrough Pain
Acute pain that comes on rapidly despite the use of pain medication.
Insulin, Short-Acting
Insulin derivatives and preparations that are designed to induce a rapid HYPOGLYCEMIC EFFECT.
Administration, Buccal
Administration of a soluble dosage form between the cheek and gingiva. It may involve direct application of a drug onto the buccal mucosa, as by painting or spraying.
Fentanyl
A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078)
Labor Pain
Pain associated with OBSTETRIC LABOR in CHILDBIRTH. It is caused primarily by UTERINE CONTRACTION as well as pressure on the CERVIX; BLADDER; and the GASTROINTESTINAL TRACT. Labor pain mostly occurs in the ABDOMEN; the GROIN; and the BACK.
Treatment Outcome
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Analgesics, Opioid
Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS.
Fourier Analysis
Analysis based on the mathematical function first formulated by Jean-Baptiste-Joseph Fourier in 1807. The function, known as the Fourier transform, describes the sinusoidal pattern of any fluctuating pattern in the physical world in terms of its amplitude and its phase. It has broad applications in biomedicine, e.g., analysis of the x-ray crystallography data pivotal in identifying the double helical nature of DNA and in analysis of other molecules, including viruses, and the modified back-projection algorithm universally used in computerized tomography imaging, etc. (From Segen, The Dictionary of Modern Medicine, 1992)
Communicable Disease Control
Programs of surveillance designed to prevent the transmission of disease by any means from person to person or from animal to man.
Education, Graduate
Studies beyond the bachelor's degree at an institution having graduate programs for the purpose of preparing for entrance into a specific field, and obtaining a higher degree.
Iceland
Epidemiology
Field of medicine concerned with the determination of causes, incidence, and characteristic behavior of disease outbreaks affecting human populations. It includes the interrelationships of host, agent, and environment as related to the distribution and control of disease.
Communicable Diseases
Night Care
Institutional night care of patients.
Comparative Effectiveness Research
Conduct and synthesis of systematic research comparing interventions and strategies to prevent, diagnose, treat, and monitor health conditions. The purpose of this research is to inform patients, providers, and decision-makers, responding to their expressed needs, about which interventions are most effective for which patients under specific circumstances. (hhs.gov/recovery/programs/cer/draftdefinition.html accessed 6/12/2009)
Matched-Pair Analysis
A type of analysis in which subjects in a study group and a comparison group are made comparable with respect to extraneous factors by individually pairing study subjects with the comparison group subjects (e.g., age-matched controls).
United States Agency for Healthcare Research and Quality
An agency of the PUBLIC HEALTH SERVICE established in 1990 to "provide indexing, abstracting, translating, publishing, and other services leading to a more effective and timely dissemination of information on research, demonstration projects, and evaluations with respect to health care to public and private entities and individuals engaged in the improvement of health care delivery..." It supersedes the National Center for Health Services Research. The United States Agency for Health Care Policy and Research was renamed Agency for Healthcare Research and Quality (AHRQ) under the Healthcare Research and Quality Act of 1999.
United States
American Recovery and Reinvestment Act
Public Law No: 111-5, enacted February 2009, makes supplemental appropriations for job preservation and creation, infrastructure investment, energy efficiency and science, assistance to the unemployed, and State and local fiscal stabilization, for fiscal year ending September 30, 2009.
Randomized Controlled Trials as Topic
Works about clinical trials that involve at least one test treatment and one control treatment, concurrent enrollment and follow-up of the test- and control-treated groups, and in which the treatments to be administered are selected by a random process, such as the use of a random-numbers table.
San Francisco
Drug Industry
That segment of commercial enterprise devoted to the design, development, and manufacture of chemical products for use in the diagnosis and treatment of disease, disability, or other dysfunction, or to improve function.
Chamaecrista
A plant genus of the family FABACEAE. Some species were reclassified from CASSIA and Senna.
Software
Sequential operating programs and data which instruct the functioning of a digital computer.
Drug Discovery
The process of finding chemicals for potential therapeutic use.
Internet
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
Drug Repositioning
The deliberate and methodical practice of finding new applications for existing drugs.
Carnivora
An order of MAMMALS, usually flesh eaters with appropriate dentition. Suborders include the terrestrial carnivores Fissipedia, and the aquatic carnivores PINNIPEDIA.
Mathematics
The deductive study of shape, quantity, and dependence. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
England
Universities
Educational institutions providing facilities for teaching and research and authorized to grant academic degrees.
Legal Guardians
A legal concept for individuals who are designated to act on behalf of persons who are considered incapable of acting in their own behalf, e.g., minors and persons found to be not mentally competent.
Mathematical Concepts
Numeric or quantitative entities, descriptions, properties, relationships, operations, and events.
Great Britain
Investments
Use for articles on the investing of funds for income or profit.
Journal Impact Factor
A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.
Marketing
Activity involved in transfer of goods from producer to consumer or in the exchange of services.
Models, Economic
Statistical models of the production, distribution, and consumption of goods and services, as well as of financial considerations. For the application of statistics to the testing and quantifying of economic theories MODELS, ECONOMETRIC is available.
Commerce
The interchange of goods or commodities, especially on a large scale, between different countries or between populations within the same country. It includes trade (the buying, selling, or exchanging of commodities, whether wholesale or retail) and business (the purchase and sale of goods to make a profit). (From Random House Unabridged Dictionary, 2d ed, p411, p2005 & p283)
Financial Management
The obtaining and management of funds for institutional needs and responsibility for fiscal affairs.
Energy-Generating Resources
Materials or phenomena which can provide energy directly or via conversion.
Critical Illness
A disease or state in which death is possible or imminent.
Clinical Trials as Topic
Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.
Critical Care
Health care provided to a critically ill patient during a medical emergency or crisis.
Polyneuropathies
Diseases of multiple peripheral nerves simultaneously. Polyneuropathies usually are characterized by symmetrical, bilateral distal motor and sensory impairment with a graded increase in severity distally. The pathological processes affecting peripheral nerves include degeneration of the axon, myelin or both. The various forms of polyneuropathy are categorized by the type of nerve affected (e.g., sensory, motor, or autonomic), by the distribution of nerve injury (e.g., distal vs. proximal), by nerve component primarily affected (e.g., demyelinating vs. axonal), by etiology, or by pattern of inheritance.
Wounds and Injuries
Damage inflicted on the body as the direct or indirect result of an external force, with or without disruption of structural continuity.
Intensive Care Units
Hospital units providing continuous surveillance and care to acutely ill patients.
Research Support as Topic
Financial support of research activities.
Alzheimer Disease
A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
Congresses as Topic
Conferences, conventions or formal meetings usually attended by delegates representing a special field of interest.
Pharmacopoeias as Topic
Authoritative treatises on drugs and preparations, their description, formulation, analytic composition, physical constants, main chemical properties used in identification, standards for strength, purity, and dosage, chemical tests for determining identity and purity, etc. They are usually published under governmental jurisdiction (e.g., USP, the United States Pharmacopoeia; BP, British Pharmacopoeia; P. Helv., the Swiss Pharmacopoeia). They differ from FORMULARIES in that they are far more complete: formularies tend to be mere listings of formulas and prescriptions.
Mental Health Associations
Voluntary organizations which support educational programs and research in psychiatry with the objective of the promotion of mental health. An early association in the United States was founded as the National Committee for Mental Hygiene in 1909, became the Mental Health Association in 1976 and later the National Mental Health Association in 1980. State and local mental health associations in this country are chartered by the national organization and affiliated with it.
International Cooperation
The interaction of persons or groups of persons representing various nations in the pursuit of a common goal or interest.
Amyloid beta-Peptides
Peptides generated from AMYLOID BETA-PEPTIDES PRECURSOR. An amyloid fibrillar form of these peptides is the major component of amyloid plaques found in individuals with Alzheimer's disease and in aged individuals with trisomy 21 (DOWN SYNDROME). The peptide is found predominantly in the nervous system, but there have been reports of its presence in non-neural tissue.
United States Food and Drug Administration
An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.

Apomorphine to Uprima: the development of a practical erectogenic drug: a personal perspective. (1/25)

The development process for apomorphine SL as an effective treatment for patients with erectile dysfunction has been somewhat unusual. As often is the case, much of the impetus for the basic research originated in academia. However, somewhat unusually, the impetus for early stage clinical research also lay in the hands of the academics. This article represents a historical perspective from one of those involved throughout.  (+info)

Update on intravenous tissue plasminogen activator for acute stroke: from clinical trials to clinical practice. (2/25)

Tissue plasminogen activator (tPA) injected intravenously within 3 hours of symptom onset has emerged as a treatment option for acute ischemic stroke. Although controversial and not universally accepted, its use in carefully selected patients is supported by evidence from randomized controlled trials and by mounting community experience. In this paper we review the literature published in the past 5 years regarding the safety, clinical trial efficacy and real-world effectiveness of intravenous tPA for stroke. First we review data from the phase III clinical trials on which approval for tPA is based. Then we summarize a growing literature of postmarketing phase IV studies and discuss the limitations and challenges that lie ahead. Our aim is to provide clinicians with an overview of this evolving therapy.  (+info)

Cardiovascular thrombotic events in controlled, clinical trials of rofecoxib. (3/25)

BACKGROUND: In comparing aspirin, nonselective nonsteroidal antiinflammatory agents (NSAIDs), and cyclooxygenase (COX)-2 inhibitors, variation in platelet inhibitory effects exists that may be associated with differential risks of cardiovascular (CV) thrombotic events. Among the randomized, controlled trials with the COX-2 inhibitor rofecoxib, one study demonstrated a significant difference between rofecoxib and its NSAID comparator (naproxen) in the risk of CV thrombotic events. A combined analysis of individual patient data was undertaken to determine whether there was an excess of CV thrombotic events in patients treated with rofecoxib compared with those treated with placebo or nonselective NSAIDs. METHODS AND RESULTS: CV thrombotic events were assessed across 23 phase IIb to V rofecoxib studies. Comparisons were made between patients taking rofecoxib and those taking either placebo, naproxen (an NSAID with near-complete inhibition of platelet function throughout its dosing interval), or another nonselective NSAIDs used in the development program (diclofenac, ibuprofen, and nabumetone). The major outcome measure was the combined end point used by the Antiplatelet Trialists' Collaboration, which includes CV, hemorrhagic, and unknown deaths; nonfatal myocardial infarctions; and nonfatal strokes. More than 28 000 patients, representing >14 000 patient-years at risk, were analyzed. The relative risk for an end point was 0.84 (95% CI: 0.51, 1.38) when comparing rofecoxib with placebo; 0.79 (95% CI: 0.40, 1.55) when comparing rofecoxib with non-naproxen NSAIDs; and 1.69 (95% CI: 1.07, 2.69) when comparing rofecoxib with naproxen. CONCLUSIONS: This analysis provides no evidence for an excess of CV events for rofecoxib relative to either placebo or the non-naproxen NSAIDs that were studied. Differences observed between rofecoxib and naproxen are likely the result of the antiplatelet effects of the latter agent.  (+info)

Clinical data gap between phase III clinical trials (pre-marketing) and phase IV (post-marketing) studies: evaluation of etanercept in rheumatoid arthritis. (4/25)

BACKGROUND: There are fundamental differences in design between phase III clinical trials and phase IV post-marketing studies that involve patient characteristics, the clinical setting (environment) and the manner of drug use. As well, many phase IV studies are extensions of randomized clinical trials (RCTs) and suffer from selection bias. OBJECTIVE: To determine if the data obtained from RCTs of etanercept (Enbrel) in the treatment of rheumatoid arthritis would be representative of the effects attainable in community practice. METHOD: An analysis was conducted comparing data from published RCTs of etanercept use in rheumatoid arthritis patients with data collected in a community based cohort study that was not an extension of an RCT. RESULTS: Baseline clinical data, such as tender or painful joint count, patient's global assessment, the heath assessment questionnaire, physical and mental component summary of the SF-36, and rheumatoid arthritis drug profile were significantly different between the patients receiving etanercept in the phase IV community cohort study and the patients enrolled in the RCTs. Differences in the baseline data for the control patients were also noted amongst the RCT studies. The treatment outcome, American College of Rheumatology (ACR) response rate of 20%, 50% and 70% at 6 month, was the same between the cohort study and the RCTs, but at 12 months the clinical response was less for the community based patients than for the RCT patients. At 6 months there were fewer withdrawals involving community-based patients than RCT patients due to less frequent withdrawals associated with lack of efficacy. At 12 months the withdrawal rate due to either a lack of efficacy or from adverse events was similar between data sets. CONCLUSION: The data from the etanercept phase III RCTs may not reflect the characteristics of patients using etanercept in community practice, nor the clinical outcomes observed by RA patients at 12 months. These discrepancies may be derived from methodological differences in study design and patient selection. On the other hand, outcomes such as withdrawal rates at 12 months appear comparable between the two types of populations.  (+info)

Clinical and bacteriologic efficacy of telithromycin in patients with bacteremic community-acquired pneumonia. (5/25)

This retrospective analysis was performed to determine the clinical and bacteriologic efficacy of the ketolide antibacterial telithromycin in patients with community-acquired pneumonia (CAP) with pneumococcal bacteremia. Patients 13 years old with radiologically confirmed CAP and a positive blood culture for Streptococcus pneumoniae at screening were analyzed from eight multicenter Phase III/IV clinical trials. In four open-label, non-comparative studies, patients received telithromycin 800 mg once daily for 7-10 days. In four randomized, controlled, double-blind, comparative studies, patients received telithromycin 800 mg once daily for 5-10 days or a comparator antimicrobial (amoxicillin 1000 mg three times daily, clarithromycin 500 mg twice daily, or trovafloxacin 200 mg once daily) for 7-10 days. In total, 118 patients (telithromycin, 94/1061 [8.9%]; comparator, 24/244 [9.8%]) had documented pneumococcal bacteremia. Those who were treated with telithromycin achieved a clinical cure rate of 90.2% (74/82, per-protocol population); S. pneumoniae was eradicated in 77/82 (93.9%) bacteremic patients who received telithromycin and 15/19 (78.9%) comparator-treated patients. Clinical cure was also observed among telithromycin-treated bacteremic patients who were infected with penicillin- or erythromycin-resistant strains of S. pneumoniae (5/7 and 8/10, respectively). In conclusion, telithromycin achieves high clinical and bacteriologic cure rates in CAP patients with pneumococcal bacteremia.  (+info)

Assessing the relationship between antigenicity and immunogenicity of human rabies vaccines. Results of a meta-analysis. (6/25)

A meta-analysis was done to study the relationship between antigenecity and immunogenecity of human rabies vaccines. The data of ten cell culture human rabies vaccine studies conducted at a single centre during 1993-2004 were used in the study. The vaccines studied included Purified Chick Embryo Cell Vaccine (Kaketsuken, Japan and Rabipur, India), Purified Vero cell Rabies Vaccine (Verorab, France), Human Diploid Cell Vaccine (MIRV, France and Rabivax, Adsorbed and Lyophilized, India) and Rhesus Diploid Rabies Vaccine (adsorbed, USA). Interestingly, it was revealed that an higher antigenecity of rabies vaccines viz. potency of > or = 5 IU per single intramuscular dose did not result in significantly higher immunogenecity, as measured by rabies virus neutralizing antibody (RVNA) titers in the vaccinees, both on day 14 (t = 0.42, p > 0.66, GMR = 1.06, 95% CI of GMR = 0.82, 1.37) and day 90 (t = 0.80, p > 0.43, GMR = 1.15, 95% CI of GMR = 0.74, 1.14). However, as there are no reports of meta-analysis of cell culture human rabies vaccine trials, to confirm this observation the authors recommend further studies in this regard.  (+info)

Ezetimibe added to statin therapy (EASY study) - an evaluation by Australian general practitioners. (7/25)

BACKGROUND: This study estimated changes in low density lipoprotein cholesterol (LDL-C) levels and proportion of patients attaining goal LDL-C <2.5 mmol/L when ezetimibe was added to existing statin monotherapy under Pharmaceutical Benefits Scheme (PBS) guidelines in a general practice setting. METHODS: Target patients were those with coronary heart disease or diabetes mellitus eligible to receive ezetimibe under PBS guidelines. They were treated with ezetimibe 10 mg/day in addition to existing statin therapy for 6 weeks. RESULTS: One hundred and thirty patients received treatment, but for effectiveness we derived a per protocol subpopulation of 95. Low density lipoprotein cholesterol was reduced by 29% (95% confidence limits, 25-34% reduction), and goal LDL-C <2.5 mmol/L was reached in 70% of patients (95% confidence limits, 59-79%). Six patients were withdrawn because of adverse events. DISCUSSION: Changes in LDL-C and goal attainment in Australian general practice with the use of ezetimibe added to a statin were highly consistent with the findings from controlled clinical trials.  (+info)

Clinical trials in severe sepsis with drotrecogin alfa (activated). (8/25)

 (+info)

Erythrocyte Sedimentation Rate Wintrobes Blood in DLF Phase IV, Gurgaon. View Prices, Labs & Book online only on | PractoErythrocyte Sedimentation Rate Wintrobes Blood in DLF Phase IV, Gurgaon. View Prices, Labs & Book online only on | Practo
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Top Paediatric Neurosurgery Hospitals in Dlf City Phase Iv, Gurgaon | CredihealthTop Paediatric Neurosurgery Hospitals in Dlf City Phase Iv, Gurgaon | Credihealth
View details of top paediatric neurosurgery hospitals in Dlf City Phase Iv, Gurgaon. Get guidance from medical experts to select best paediatric neurosurgery hospital in Dlf City Phase Iv
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20-th National Congress of Anesthesiology and Intensive Care with international participation20-th National Congress of Anesthesiology and Intensive Care with international participation
20-th National Congress of Anesthesiology and Intensive Care with international participation. 26-29 October 2017. Black sea. Hotel Sol Nessebar Palace. Nessebar. Organized by:. BULSPEN. MILITARY MEDICAL ACADEMY. UNION OF BULGARIAN MEDICAL SPECIALISTS. BULGARIAN ASSOCIATION FOR STUDY AND TREATMENT OF PAIN. Read ...
http://anesthesiology.bg/index.php/221-20-th-national-congress-of-anesthesiology-and-intensive-care-with-international-participation
Manufacturer of anti-cancer Oncology products in IndiaManufacturer of anti-cancer Oncology products in India
A WHO-GMP certified Anticancer drugs manufacturer in India, exporter, dealer, distributor in cancer products, 12+ year Exp in quality oncology products.
https://www.zuviuslifesciences.in/our-products/
The Gideon the Ninth Reread: Chapters 7 and 8 | Tor.comThe Gideon the Ninth Reread: Chapters 7 and 8 | Tor.com
As Gideon gazes upon the planet, we learn that this is the home of the Lord of the House of the First, the Lord Undying, and he has not been here in nine thousand years. That is some vacation!. The ride from the Ninth House to the First took just an hour, in a pilot-less shuttle. (Look, Ma, no Han!) And now theyre waiting for First House security to grant them access to the landing dock. As Gideon continues to gaze out the window, Harrow worries her prayer knuckles, and Gideon wonders why she isnt traveling on grave dirt from home to keep her power source, like cohort adepts do in the comics she has read. Like a Space Dracula! And Gideon briefly considers kicking Harrows ass while shes weak, but shes much too interested in what is going on as the shuttle finally lands.. The planet is incredibly bright, and Harrow covers her eyes with a black veil, as they have always lived in almost complete darkness. She offers a veil to Gideon, but Gideon came prepared: She whips out a pair of mirrored ...
https://www.tor.com/2020/02/11/the-gideon-the-ninth-reread-chapters-7-and-8/comment-page-1/
Infant Health and Development Program, Phase IV, 2001-2004 [United States]Infant Health and Development Program, Phase IV, 2001-2004 [United States]
The Infant Health and Development Program (IHDP) was a multisite, randomized, controlled trial of an educational intervention until three years of age for low birth weight preterm infants born in 1984-1985. There were three components to the intervention: (1) an educational program delivered through home visits (weekly during the first year and every other week during the second and third years of life), (2) a daily center-based program beginning at 12 months corrected for duration of gestation, and (3) parent support groups coinciding with the start of the center-based program. Previously, the subjects were assessed at baseline up to age 3 (Phase I), age 5 (Phase II), and age 8 (Phase III). Phase IV assessed them at age 18. This data collection contains selected variables from all four phases that were used in analyses reported in two articles by the principal investigators and others: McCormick, Marie C., Jeanne Brooks-Gunn, Stephen L. Buka, Julie Goldman, Jennifer Yu, Mikhail Salganik, David ...
http://www.icpsr.umich.edu/icpsrweb/HMCA/studies/23580?keyword=intervention&permit%5B0%5D=AVAILABLE
A Phase IV Trial of Cesamet™ Given With Standard Antiemetic Therapy for Chemotherapy-induced Nausea and Vomiting - Full Text...A Phase IV Trial of Cesamet™ Given With Standard Antiemetic Therapy for Chemotherapy-induced Nausea and Vomiting - Full Text...
This is a Phase IV, open-label, sequential treatment study in patients who are receiving standard chemotherapy for non-small cell lung cancer, breast cancer, or colorectal cancer. (See Section 4.2.1 for eligible treatment regimens.) The study will take place during the first 2 cycles of chemotherapy.. Phase 1 of study:. Prior to the first dose of chemotherapy, patients will be instructed on how to complete their patient diary, which will include a Visual Analogue Scale (VAS) for nausea and a VAS for pain. In addition, the diary will include a section to list their current pain medications (see Sample Patient Diary in Appendix I). After being instructed, patients will complete the VAS for nausea and for pain, as well as listing their current pain medications. Patients will then receive chemotherapy on Day 1 of Cycle 1 in combination with the pre-defined standard serotonin antagonist/corticosteroid regimen.. Beginning on Day 2, the diary will be completed for 5 consecutive days (Days 2-6). Each ...
https://clinicaltrials.gov/show/NCT00418678
A 8-week, Multi-Centre, Open-label, Non-comparative, Phase IV Study of the Efficacy and Safety of Quetiapine Fumarate Extended...A 8-week, Multi-Centre, Open-label, Non-comparative, Phase IV Study of the Efficacy and Safety of Quetiapine Fumarate Extended...
A 8-week, Multi-Centre, Open-label, Non-comparative, Phase IV Study of the Efficacy and Safety of Quetiapine Fumarate Extended Release (Seroquel XR) With Daily Dose 400mg-800mg in the Treatment of Acute Schizophrenic Patients ...
http://adisinsight.springer.com/trials/700038493?error=cookies_not_supported&code=538c7aec-08af-475c-af88-7c346ac3eba7
Best Neuro Radiologist in Dlf City Phase Iv, Gurgaon | CredihealthBest Neuro Radiologist in Dlf City Phase Iv, Gurgaon | Credihealth
Neuro Radiologist in Dlf City Phase Iv. Get guidance to select the best neuroradiology doctor from trusted hospitals Gurgaon, view fees and book appointment on Credihealth
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Multicenter, interventional, single-arm, phase IV study evaluating tolerability of Eribulin and its relationship with a set of...Multicenter, interventional, single-arm, phase IV study evaluating tolerability of Eribulin and its relationship with a set of...
This multicenter, interventional, single-arm, phase IV study is evaluating the tolerability of eribulin and its relationship with a set of polymorphisms in
http://adisinsight.springer.com/trials/700246597?error=cookies_not_supported&code=6078bd85-c080-4a66-b5f8-3a560248c41e
Phase IV - Roadway and Drainage Improvements | Augusta, GA - Official WebsitePhase IV - Roadway and Drainage Improvements | Augusta, GA - Official Website
Description: Phase IV of East Augusta includes drainage and street improvements. Improvements consists of underground storm drainage and detention system. ...
https://augustaga.gov/2550/Phase-IV---Roadway-and-Drainage-Improvem
GIDEON Guide to Medically Important Yeasts - GIDEON - Global Infectious Diseases and Epidemiology Online NetworkGIDEON Guide to Medically Important Yeasts - GIDEON - Global Infectious Diseases and Epidemiology Online Network
This is one in a series of GIDEON ebooks which explore all individual infectious diseases, drugs, vaccines, outbreaks, surveys and pathogens in every country of the world. Data are based on the GIDEON web application (www.gideononline.com) which relies on standard textbooks and peer-review journals, supplemented by an ongoing search of the medical literature.. ...
https://www.gideononline.com/ebooks/yeasts/
Xylotrupes Gideon Classification Essay… Aziz Ansari My Cousin Harris College Essay - English Essay Writing HelpXylotrupes Gideon Classification Essay… Aziz Ansari My Cousin Harris College Essay - English Essay Writing Help
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A Successful Launch of a New Oncology Product Requires Global Teams &... ( CHAPEL HILL N.C. Nov. 1 2012 /- Globa...)A Successful Launch of a New Oncology Product Requires Global Teams &... ( CHAPEL HILL N.C. Nov. 1 2012 /- Globa...)
...CHAPEL HILL N.C. Nov. 1 2012 /- Global Strategic Marke...Add to this increasing regulatory challenges regional differences and...To help marketing leaders throughout the pharma and medical device ind...This report seeks to help companies understand the investment levels ...,A,Successful,Launch,of,a,New,Oncology,Product,Requires,Global,Teams,&,Planning,medicine,advanced medical technology,medical laboratory technology,medical device technology,latest medical technology,Health
http://www.bio-medicine.org/medicine-technology-1/A-Successful-Launch-of-a-New-Oncology-Product-Requires-Global-Teams--26amp-3B-Planning-28576-1/
Market Research Radiation Oncology Products OverviewMarket Research Radiation Oncology Products Overview
IMVs latest Radiation Therapy Market Summary Report estimates 1,029 thousand courses of treatment with radiation were initiated at 2,270 hospital and freestanding sites in the United States in 2016. This is a 12% decrease from the courses of treatment initiated in 2015. The top three cancers treated with radiation at these locations continue to be breast, prostate and lung. Learn more about radiation therapy treatment trends including capabilities for IGRT, rotational ARC therapy, stereotactic radiotherapy and brachytherapy in the Radiation Therapy Market Summary Report. Market share, age and features of installed radiation therapy units, treatment planning units, simulators and brachytherapy equipment are also provided. Find information about the productivity of radiation therapy staff and their satisfaction with their equipment service providers from one or more of the IMV products listed below ...
http://www.imvinfo.com/index.aspx?sec=ronc&sub=def
Rethinking Research Ethics: Researchers Challenge Post-marketing Trial Practices - Healthcanal.com : Healthcanal.comRethinking Research Ethics: Researchers Challenge Post-marketing Trial Practices - Healthcanal.com : Healthcanal.com
Published in Science, McGills Jonathan Kimmelman and Benjamin Carlisle and CMUs Alex John London argue that current research ethics frameworks do not flag drug trials that, while not putting patients at risk, produce biased evidence. As an example, they point to phase IV research - when pharmaceutical companies test drugs and devices that have been approved for marketing. They insist that without an adequate system of checks in place, phase IV trials will continue to be used by drug companies to market products without generating the information that clinicians and policy makers can use to improve care and maintain a more cost-effective health system.. Rigorously designed and executed research has a critical role in improving patient care and restraining ballooning healthcare costs, said Kimmelman, associate professor of biomedical ethics. There is currently a push to streamline the ethical review of research. In this process, oversight systems should be empowered to separate scientific ...
https://www.healthcanal.com/drugs-approvals-trials/28988-rethinking-research-ethics-researchers-challenge-post-marketing-trial-practices.html
Immunomedics Announces U.S. Patent for Antibody-SN-38 ConjugatesImmunomedics Announces U.S. Patent for Antibody-SN-38 Conjugates
MORRIS PLAINS, N.J., Dec. 31, 2013-- Immunomedics, Inc., a biopharmaceutical company primarily focused on the development of monoclonal antibody-based products for the targeted treatment of cancer, autoimmune and other serious diseases, today announced the issuance of U.S. patent no. 8,617,558 for additional claims under the patent family Camptothecin-binding moiety conjugates, and U.S. patent no. 8,617,518 with additional claims for the patent family Methods and compositions for improved F-18 labeling of proteins, peptides and other molecules.
https://www.cnbc.com/2013/12/31/globe-newswire-immunomedics-announces-us-patent-for-antibody-sn-38-conjugates.html
Prometheus launches PROCLIVITY 02, a phase IV multi-center study | Nestlé Health SciencePrometheus launches PROCLIVITY 02, a phase IV multi-center study | Nestlé Health Science
Prometheus Laboratories Inc., a specialty pharmaceutical and diagnostic company, announces that PROCLIVITY02, a multi-center study comparing the sequence of Proleukin® (High Dose Interleukin-2 (HD IL-2) followed by ipilimumab to the converse order, as therapy in patients with metastatic melanoma (mM) has Investigational Review Board approval and anticipates enrolling patients this summer.
https://www.nestlehealthscience.com/newsroom/press-releases/Prometheus-Laboratories-Launches-Next-Clinical-Trial
Phase IV - Contract PharmaPhase IV - Contract Pharma
Following FDA approval and marketing, drug companies may conduct further studies on their products. These post-approval studies have several objectives, including comparing the drug with other drugs already in the market, monitoring the drugs long-t
http://www.contractpharma.com/contents/view_glossary/2012-02-27/phase-iv/
retired docs thoughts: Are Phase IV trials really seed trials-another way to manipulate physician behavior?retired docs thoughts: Are Phase IV trials really seed trials-another way to manipulate physician behavior?
I reach here seeking information about LABA (Long acting beta-agonist) for my asthma treatment. I´ve asthma induced by exercise and after my swimming train I use to take Formeterol (Foradil). Some heart strokes on higher rythms of exercise warning me that something is not going allright. So I decide to leave it, but how could I prevent EIAsthma ? If I take a corticosteroid, and I have for 20 years my colesterol increases and fat body also. What is a fact is that a lot of Olimpyc Gold Medals have EIA. What alternatives could I take ? One thing I could confirm to all of you is that swimming improves your lung function and reduces your asthma crises. But it is not a 100% natural treatment, if you are in a middle of a crises I would advise you to go swimming. What about acunpuncture ? or any other natural treatment ...
http://mdredux.blogspot.com/2006/06/are-phase-iv-trials-really-seed-trials.html?showComment=1150979700000
A Phase IV, Open-label Single-arm Study Investigating the Pharmacokinetics and Pharmacodynamics of the Antiretroviral...A Phase IV, Open-label Single-arm Study Investigating the Pharmacokinetics and Pharmacodynamics of the Antiretroviral...
For patients who are starting to take antiretroviral medication (to treat HIV) for the first time, there are now a variety of different medicines which may be taken together as a combination in order to form an effective treatment which suppresses the virus for prolonged periods of time. Currently, national guidelines recommend the use of two different drugs of one type (the nucleoside/ nucleotide reverse transcriptase inhibitors, NRTI often known as nukes) with a third drug from one of two other types (either a nonnucleoside reverse transcriptase inhibitor, known as an NNRTI or nonnuke, or a protease inhibitor, known as a PI) to form a treatment regime of three active drugs. In the UK and Europe, all PIs are given in combination with a small dose of a second PI, ritonavir, which has the effect of boosting the levels of the active PI in the bloodstream.. The investigators know from both research studies and patient experience in clinic that a combination of a ritonavirboosted PI with an ...
https://clinicaltrials.gov/show/NCT01736761?order=18
Evaluation of a complex intervention to improve primary care prescribing: a phase IV segmented regression interrupted time...Evaluation of a complex intervention to improve primary care prescribing: a phase IV segmented regression interrupted time...
Thank you for recommending British Journal of General Practice.. NOTE: We only request your email address so that the person to whom you are recommending the page knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...
https://bjgp.org/content/67/658/e352/tab-e-letters
Resection Surgery (Phase IV)Resection Surgery (Phase IV)
When you express interest in a specific study, the information from your profile will be sent to the doctor conducting that study. If youre eligible to participate, you may be contacted by a nurse or study coordinator. If you select a health category rather than a specific study, doctors who have active studies in that area may contact you to ask if you would like to participate. In both cases, you will be contacted by the preferred method (email or phone) that you specified in your profile. ...
http://www.epilepsy.yale.edu/care/surgical/phaseiv.aspx
D-Tox Phase IV - Blood DetectiveD-Tox Phase IV - Blood Detective
Blood Logic, Inc. is a nutritional supplement, education, health software and professional consulting company providing services to the general public and to health professionals. Dr. Michael Wald was nicknamed the Blood Detective by a grateful patient when he uncovered the cause of her persistent health problems when many other health care providers had failed. Dr. Walds motto, branding and exceptional clinical skills have propelled him into the media spotlight appearing on ABC World News Tonight with Diane Sawyer, Fox National News, Channel 11 PIX and many other programs.
http://www.blooddetective.com/d-tox-phase-iv
ISRCTN - ISRCTN79120387: A randomised, single-masked, phase IV pilot study of the efficacy and safety of adjunctive...ISRCTN - ISRCTN79120387: A randomised, single-masked, phase IV pilot study of the efficacy and safety of adjunctive...
Avastin® will be administered intravitreally in a single or dual-dose regimen of 1.25 mg (in 0.05 ml) 2 weeks prior to vitrectomy and at the end of vitrectomy if internal tamponade (oil, air or gas) was not used. No sham intravitreal injections will be given before or after vitrectomy if patient is randomized to the usual treatment group. ...
http://www.isrctn.com/ISRCTN79120387
XA Falcon GT-HO Phase IV: Was it destined to fail at Bathurst?XA Falcon GT-HO Phase IV: Was it destined to fail at Bathurst?
The story of the greatest XA Falcon GT-HO of them all, the journey which saw it never race in the event it was designed to win and why it wouldve stumbled if it did.
http://www.motorsportretro.com/2015/01/xa-falcon-gt-ho-phase-iv-was-it-destined-to-fail-at-bathurst/
Phase IV Transition - Page 2 - Stardust@homePhase IV Transition - Page 2 - [email protected]
Please note that Power Movies with a point value of 15 to 30 are considered by the [email protected] team to be fairly hard to identify correctly, and therefore, are expected to be missed from time-to-time by even the best dusters. Power Movie values higher than 30 should be considered extremely hard, if not impossible to spot ...
https://stardustathome.ssl.berkeley.edu/forum/viewtopic.php?p=19178
Phase IV: 2018Phase IV: 2018
SKuOR, Interdisciplinary Centre for Urban Culture and Public Space, Stiftungsgastprofessur Stadtkultur und öffentlicher Raum, Raumforschung, Raumproduktion, Critical Urban Studies
https://skuor.tuwien.ac.at/de/about/programm/institutionelles-setting-2009-2012institutional-setting-2009-2012marco-institucional-2009-2012/phase-iv-2018
Equine encephalitis: Global Status - GIDEON - Global Infectious Diseases and Epidemiology Online NetworkEquine encephalitis: Global Status - GIDEON - Global Infectious Diseases and Epidemiology Online Network
Equine encephalitis: Global Status is one in a series of GIDEON ebooks which explore all individual infectious diseases, drugs, vaccines, outbreaks, surveys and pathogens in every country of the world. Data are based on the GIDEON web application (www.gideononline.com) which relies on standard text books, peer-review journals, Health Ministry reports and ProMED, supplemented by an ongoing exhaustive search of the medical literature.. Chapters are arranged alphabetically, by disease. Each chapter includes ...
https://www.gideononline.com/ebooks/disease/equine-encephalitis-global-status/
Sinclair Oil Locations & Hours Near Gideon, MO - YP.comSinclair Oil Locations & Hours Near Gideon, MO - YP.com
Find 9 listings related to Sinclair Oil in Gideon on YP.com. See reviews, photos, directions, phone numbers and more for Sinclair Oil locations in Gideon, MO.
https://www.yellowpages.com/gideon-mo/sinclair-oil
Re: IiKFMKdlgvCLDQ - Hosting for Text and Code online freeRe: IiKFMKdlgvCLDQ - Hosting for Text and Code online free
Three years ,a href= https://imgur.com/rsrMA5B ,rapaflo side effects drug interactions,/a, In the face of these challenges, there is an increasing openness to international participation ,a href= https://imgur.com/2gkTF8Q ,crila prostate herbal,/a, In a review of the evidence that indoor tanning does damage, and has no health benefits, the study authors point out that the new rules will force device manufacturers and salons to do more to protect users. ,a href= https://imgur.com/GHH1Mi2#watching ,vimax pills.com,/a, On the new album, Grande does indeed want “everything”: EDM (“Break Free”), several hip-hop-pop tunes, ball-gown-ready ballads, some R&B jams, and even ’60s-inflected pop (“Bang Bang,” which features Nicki Minaj and Jesse J). ,a href= http://warcraft-3.info/ramipril-10-mg-effets-secondaires#shove ,ramipril 2.5 mg tablets,/a, This is an easy one: Geno Smith to the Pats, Tom Brady to the Jets and call it even ...
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Microstructural characterization of thin laser bonded coatings based on transitional metal oxides powderMicrostructural characterization of thin laser bonded coatings based on transitional metal oxides powder
23rd National Scientific Symposium with International Participation on Meteorology and Meteorology Assurance, Sozopol, BG, September 7-11, ...
https://publikationen.bibliothek.kit.edu/240093996
Gideon K. D. Zamba - University of Iowa College of Public HealthGideon K. D. Zamba - University of Iowa College of Public Health
Information on Associate Professor Gideon K. D. Zamba of the Department of Biostatistics at the University of Iowa College of Public Health.
https://www.public-health.uiowa.edu/people/gideon-zamba/
Yangzhou Gideon Chemical Co., Ltd.--P-Toluic acid|M-Toluic acid|1,4-Naphthoquinone|M-ChlorobenzylamiYangzhou Gideon Chemical Co., Ltd.--P-Toluic acid|M-Toluic acid|1,4-Naphthoquinone|M-Chlorobenzylami
Yangzhou Gideon Chemical Co., Ltd. located on the side of the Ancient Grand and the crossroads of Baqiao onBeijing Shanghai Expressway.
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Xenical for sale uk - Best canadian pharmacyXenical for sale uk - Best canadian pharmacy
About Pfizer Oncology At Pfizer Oncology, we are pleased that Gilead is http://visionsunltd.com/xenical-price-comparison/ using our manufacturing capacity to help support Japan in its subsequent reports on what is xenical tablets used for Form 10-K and 10-Q filed with the COVID-19 pandemic. LY-CoV555 is the market authorization holder worldwide and will hold all trademarks for the rapid development of novel biopharmaceuticals. Our hope is that, subject to a large portfolio of oncology product candidates includes individualized and off-the-shelf mRNA-based therapies, innovative chimeric antigen receptor T cells, bi-specific checkpoint immuno-modulators, targeted cancer antibodies and small molecules. Cancer Stat Facts: Lung and Bronchus what is xenical tablets used for Cancer. View source version on businesswire.. D milestones, including three FDA approvals for new medicines, positive phase 3 study showed higher investigational doses of their BNT162 mRNA-based vaccine candidate against SARS-CoV2, ...
http://mail.rielo.com/xenical-for-sale-uk/
AACR Virtual Annual Meeting II: FDAs Project Renewal and Project Socrates - American Association for Cancer Research (AACR)AACR Virtual Annual Meeting II: FDAs Project Renewal and Project Socrates - American Association for Cancer Research (AACR)
Since its establishment in January 2017, the Oncology Center of Excellence (OCE), part of the U.S. Food and Drug Administration, has sought to create a unified and collaborative scientific environment to advance the development and regulation of oncology products for patients with cancer. As one means of working toward this goal, the OCE has developed several projects that draw on the skills and expertise of the oncology community.
https://www.aacr.org/professionals/blog/aacr-virtual-annual-meeting-ii-fdas-project-renewal-and-project-socrates/
VBI Vaccines Reports Rapid Seroprotection Results from an Interim Analysis of a Phase IV Postmarketing Study of its Sci-B-Vac...VBI Vaccines Reports Rapid Seroprotection Results from an Interim Analysis of a Phase IV Postmarketing Study of its Sci-B-Vac...
CAMBRIDGE, MASSACHUSETTS--(Marketwired - Nov. 14, 2016) - VBI Vaccines Inc. (NASDAQ:VBIV)(TSX:VBV) (VBI) today reported interim results from an ongoing Phase IV postmarketing study to evaluate Sci-B-Vac™, VBIs licensed third-generation hepatitis B vaccine, in healthy adults. In its interim analysis, Sci-B-Vac™ was found to be well-tolerated and demonstrated rapid onset of...
http://www.marketwired.com/press-release/vbi-vaccines-reports-rapid-seroprotection-results-from-interim-analysis-phase-iv-postmarketing-nasdaq-vbiv-2175220.htm
Notice to Readers: Manufacturers Recall of Human Rabies Vaccine --- April 2, 2004Notice to Readers: Manufacturers Recall of Human Rabies Vaccine --- April 2, 2004
On April 2, this notice was posted as an MMWR Dispatch on the MMWR website (http://www.cdc.gov/mmwr). CDC and the Food and Drug Administration (FDA) have been notified that a recent quality-assurance test of IMOVAX® Rabies Vaccine (Aventis Pasteur, Swiftwater, Pennsylvania) identified the presence of noninactivated Pitman-Moore virus (the attenuated vaccine strain) in a single product lot. IMOVAX® is an inactivated viral vaccine and should not contain live virus. The vaccine lot containing noninactivated virus was not distributed. As a precautionary measure, Aventis Pasteur initiated a voluntary recall of lot numbers X0667-2, X0667-3, W1419-2, and W1419-3, which were produced during the same period as the lot that contained noninactivated Pitman-Moore virus. These four lots, which were distributed in the United States from September 23, 2003 through April 2, 2004, passed all FDA-approved release tests, including testing to confirm the absence of live virus. These test results suggest that any ...
https://www.cdc.gov/mmwr/preview/mmwrhtml/mm5313a3.htm
History - The Russian Conference with international participation «Optogenetics+ 2020»History - The Russian Conference with international participation «Optogenetics+ 2020»
2.1. Automated processing of personal data - processing of personal data using computer equipment;. 2.2. Personal Data Blocking - temporary termination of personal data processing (except if processing is necessary to clarify personal data);. 2.3. Website - a collection of graphic and informational materials, as well as computer programs and databases, ensuring their availability on the Internet at the network address https://conf20.iephb.ru;. 2.4. Personal data information system - a set of personal data contained in databases, and information technologies and technical means providing for their processing;. 2.5. Personal Data Impersonation - actions, as a result of which it is impossible to determine without the use of additional information the identity of personal data to a specific User or other personal data subject;. 2.6. Personal Data Processing - any action (operation) or set of actions (operations) performed using automation tools or without using such tools with personal data, ...
https://conf20.iephb.ru/history/
Exercise - Yings FitnessExercise - Yings Fitness
the prepared cotyledon of the wheat plant; it is usually found in powder form. Whether or not you believe that it is as great as people say it is, wheatgrass is proven to be a good source of important nutrients such as vitamins A,C,E, iron, calcium, amino acids, etc. So from that stand point, it cant hurt to ingest wheatgrass (in moderation of course). However, there are many additional claims on the benefits of wheatgrass including managing cholesterol and high blood pressure, losing weight, promoting digestion, detoxing, etc. It is also used in alternative healing methods to combat cancer, arthritis, and diabetes. These additional claims, while a possibility, have not been rigorously tested by scientists. Despite this, wheatgrass is still good for you and if you can stand the taste, you should try it.. Now for the preparation of ingesting wheatgrass, it is commonly used in its juice form or in powder form. The powder form is used so that you can mix it with other liquids/smoothies. ...
http://ying.fitness/category/exercise/
International phase IV validation study of an EORTC quality of life questionnaire for testicular cancer patients: the EORTC QLQ...International phase IV validation study of an EORTC quality of life questionnaire for testicular cancer patients: the EORTC QLQ...
Given the high cure-rate for testicular cancer (TC) and the patients young age, comprehensive evaluation of health-related quality of life (HRQOL) is an important consideration in this patient population.
https://www.urotoday.com/recent-abstracts/urologic-oncology/testicular-cancer/108524-international-phase-iv-validation-study-of-an-eortc-quality-of-life-questionnaire-for-testicular-cancer-patients-the-eortc-qlq-tc26.html
Writing on the Moon: February 2014Writing on the Moon: February 2014
But he only ever directed one feature film himself, and for that, he chose to make ... well, what is Phase IV exactly? In its crudest terms, its the story of a tiny handful of humans - two at first and then three - battling super-intelligent ants in the American desert. Which makes it sound like THEM! or possibly Tremors, two films it has almost nothing in common with. It most certainly isnt a horror movie, though it has horror elements, and though it is a science-fiction movie, its one far more absorbed with scientific process than technology or big ideas. In fact, through its three distinct chapters it skips genre quite unapologetically, as the scale of the threat metamorphoses from gee, these ants sure are getting feisty, through gee, these ants are putting up a much better fight than youd expect from, you know, ants, to ... well, that would be a spoiler, and to spoil Phase IV would be a shame, because amongst its many virtues are that it absolutely isnt like the film youre imaging ...
http://davidtallerman.blogspot.co.uk/2014/02/
New therapeutic approach to Tourette Syndrome in children based on a randomized placebo-controlled double-blind phase IV study...New therapeutic approach to Tourette Syndrome in children based on a randomized placebo-controlled double-blind phase IV study...
TS is considered to be a rare neurological illness, although increasingly high rates of prevalence are being reported in current studies. The condition is seldom diagnosed, due to ignorance of its existence and characteristics [7]. Until very recently, TS was only recognized as such for the most severe cases, in which there was an important degree of functional limitation and very evident coprolalia. Although this situation is changing, TS is still considered an uncommon disease.. Few clinical studies have been made with children, because, in addition to the normal difficulties arising in this kind of study (with adults), legal considerations must be borne in mind, due to the logical necessity to protect minors. Nevertheless, such studies are clearly needed [33].. TS is a neurological illness, and its physiopathological and inherited alterations, as well as aggravating environmental factors, are increasingly well understood [10]. Effective treatment is provided by dopamine post-synaptic D2 ...
https://trialsjournal.biomedcentral.com/articles/10.1186/1745-6215-10-16
1852 Gideon Mantells fused Spine - Stock Image C011/0959 - Science Photo Library1852 Gideon Mantells fused Spine - Stock Image C011/0959 - Science Photo Library
A dorsal view of Dr. Gideon Mantells fused and distorted spine preserved at the Royal College of Surgeons (RCS) from Hodgkin & Adams, Med. Chir. Trans 1854: 37: 167-80. Gideon Mantell, discoverer of the dinosaurs, died of an opium overdose to relieve pain on 11th Nov 1852. His spine was donated at his request to the RCS to elucidate a condition which had been a mystery in life. The spine went to the Hunterian Museum. It revealed curvature (scoliosis) and osteo arthritis - a long term condition exacerbated by a carriage accident nearly ten years earlier. Ironically it was fusion of the lower vertebrae that was a defining feature of the dinosaurs he helped discover. And the man who made that association, and who presided over the Hunterian Museum, was his arch-enemy Richard Owen. Though it is often said the specimen was destroyed in WWII, it was actually disposed-of to save space in 1970. - Stock Image C011/0959
http://www.sciencephoto.com/media/431867/view
Joe Gideon and the Shark - Harum Scarum (2009)Joe Gideon and the Shark - Harum Scarum (2009)
Joe Gideon and his sister, Viva (aka Shark), played together in Bikini Atol, now they have released their first album. Their combination of thumping rhythms, raw bluesy guitar and Joe Gideons rough county-style vocals/spoken word (think Mark E. Smith from The Fall) weaving melancholic stories makes for compelling listening. The whole sound is stripped bare, raw and bluesy with light production (The Kills, Jon Spencer.., Fiery Furnaces e.a.). Gideon provides the main vocals and guitar and Viva plays the drums, piano and guitar, whilst adding beautifully delicate backing vocals. The record kicks off with title track Harum Scarum, a great introduction to the pounding rhythms of the band, while DOL is the real stand out track, with the repetitive chanting Daughter of a loony followed by a huge sleazy blues riff drawing you into the song (think Grinderman). This is a stunning debut from a musically brilliant duo who will no doubt go far this year ...
http://pascalitolb6.blogspot.com/2009/04/joe-gideon-and-shark-harum-scarum-2009.html
A. Seliverstov - PublicationsA. Seliverstov - Publications
Authors: Seliverstov A.. Note on complex cubic forms with vanishing hessian, All-Russian Conference with International Participation Control Theory and Mathematical Modeling, dedicated to the memory of professor N. V. Azbelev and professor E. L. Tonkov (Izhevsk, Russia, June 08 12, 2015). - Izhevsk: Udmurt State University, 2015. P. 333-334 (in Russian ...
http://iitp.ru/publications/index.php?lang=en&search=&datestart=&datefinish=&type=&sort=&author=&userid=58&structure=&intcited=&page=1
A. Seliverstov - PublicationsA. Seliverstov - Publications
Authors: Seliverstov A.. Note on complex cubic forms with vanishing hessian, All-Russian Conference with International Participation Control Theory and Mathematical Modeling, dedicated to the memory of professor N. V. Azbelev and professor E. L. Tonkov (Izhevsk, Russia, June 08 12, 2015). - Izhevsk: Udmurt State University, 2015. P. 333-334 (in Russian ...
http://iitp.ru/publications/index.php?lang=en&search=&datestart=&datefinish=&type=&sort=&author=&structure=&userid=58&intcited=&page=3
Phylogenetic Analysis of Ukrainian Isolates of RNA Viruses of Plants | CredoWebPhylogenetic Analysis of Ukrainian Isolates of RNA Viruses of Plants | CredoWeb
Abstract from Fourth National Congress of Virology with International Participation /Days of Virology in Bulgaria Sofia, May 18th - 20th, 2016. Прочетете цялата статия от Acta Microbiologica Bulgarica в CredoWeb
https://www.credoweb.bg/publication/88011/phylogenetic-analysis-of-ukrainian-isolates-of-rna-viruses-of-plants
Yaşam HastaneleriYaşam Hastaneleri
8. Hasan Yucel, Hakki Kaya, Ali Zorlu, Mustafa Kutay Yıldırımlı, Enver Sancakdar, Hakan Gunes, Recep Kurt, Ufuk Ozgul, Okan Onur Turgut, Mehmet Birhan Yılmaz, 30th Turkish Cardiology Congress With International Participation Abstracts, Anadolu Kardiyoloji Dergisi/The Anatolian Journal Of Cardiology Higher Cancer Antigen 125 Levels Are Associated With İncreased Risk Of New-Onset Atrial Fibrillation İn Patients With Systolic Heart Failure 237 Pp, Antalya, Türkiye, 23-26 Ekim 14 (1): 1-165, ...
https://www.yasamhastaneleri.com/uzm-dr-enver-sancaktar
From Gavdos to Nordkapp with COCO-MAT wooden bike! - COCO-MATFrom Gavdos to Nordkapp with COCO-MAT wooden bike! - COCO-MAT
12,400 km with COCO-MATs wooden bike - An unforgettable Greek effort with international participation and impact!. True to his passion for bikes, COCO-MATs founder Paul Efmorfidis completed on July 2nd a great cycling trip with Greek handmade wooden bicycle. Together with a few daring and dreamy friends, they crossed Europe, from the southernmost point of Greece, Gavdos, to the northernmost point, Nordkapp in Norway. The route was planned based on COCO-MAT stores across Europe, which served as resting spots. The journey of 12.400 km lasted 114 days, with lot of stubbornness, fatigue but also with a passion for the ultimate goal.. At the end of the journey, the mayor of Nordkapp Mayor, Mrs. Kristina Hansen, welcomed the team with great enthusiasm and appreciation. Paul donated a wooden bicycle on behalf of COCO-MAT, which will remain at the cape of Nordcapp as a symbol of unification of the two countries.. During their travel, Paul and his companions raised awareness for the Pillow Positive, ...
https://www.coco-mat.com/us_en/2018/07/gavdos-nordkapp-coco-mat-wooden-bike/
Monitoring of effectiveness of ramipril-amlodipine fixed combination, a non-interventional trial (Ramona study). Subgroup...Monitoring of effectiveness of ramipril-amlodipine fixed combination, a non-interventional trial (Ramona study). Subgroup...
[Hypertension and chronic kidney disease are independent cardiovascular risk factors. The 5th Cardiovascular Consensus Conference has recommended chronic kidney disease in high-risk category. In chronic kidney disease hypertension is observed in most cases. In patients with chronic kidney disease blood pressure targets are as 140/90 mmHg blood pressure below must be achieved without overt proteinuria. In chronic kidney disease combined antihypertensive therapy treatment should be initiated according the Hungarian Society of Hypertension recommendations. Aims: Monitoring the effectiveness and safety of the fix combination of ramipril/amlodipine Egiramlon® therapy in chronic kidney disease suffering from mild or moderate hypertension despite antihypertensive treatment. Patients and methods: Open, prospective, phase IV clinical observational study, which involved known chronic kidney disease (age over 18 years) with mild or moderate hypertension. Ramipril/amlodipine fixed combination (5/5, 5/10, 10/5 or,
https://elitmed.hu/en/publications/hypertension-and-nephrology/monitoring-of-effectiveness-of-ramipril-amlodipine-fixed-combination-a-non-interventional-trial-ramona-study-subgroup-analysis-of-patients-with-chronic-kidney-disease
Gideon Kersten | Drug Delivery TechnologyGideon Kersten | Drug Delivery Technology
Gideon Kersten is a vaccinologist and department head at the Institute for Translational Vaccinology, InTraVacc, in Bilthoven, The Netherlands. He is responsible for the analytical development and vaccine formulation development at InTraVacc. He has a master in Biochemistry (University of Leiden) and holds a PhD in Pharmacy on subunit vaccines (University of Utrecht). His research interests are in the development of antigen delivery systems, adjuvants and needle free delivery systems for vaccines, systems vaccinology and stabilisation of vaccines. Needle free delivery comprises dermal and mucosal vaccine delivery. Stabilisation comprises lyophilisationand spraydrying. With regard to analytics his interest is focused on the characterisation of (protein) antigens with immunochemical and physico-chemical techniques and the development of in vitro alternatives for animal testing.. ...
http://drugdeliverytechnology.leidenuniv.nl/people/kersten
The Cadaver of Gideon Wyck | The Bedlam FilesThe Cadaver of Gideon Wyck | The Bedlam Files
By Alexander Laing (Macmillan; 1934/60). A real curiosity: a strange, rather morbid mystery that in recent years has received attention as a novel of horror (having been favorably profiled in the essential HORROR: THE 100 BEST BOOKS and TWILIGHT ZONE MAGAZINES seminal August 83 Fantasy Five-Foot Bookshelf). Thats doubtless due to the many bizarre and grotesque elements author Alexander Laing includes, such as the near simultaneous birth of five mutant babies and the last-minute revelation that a pivotal character has a half-formed twin brother attached to his body.. The majority of this first person account is told by a medical student looking to solve the murder of Professor Gideon Wyck. Said killing doesnt occur until about fifty pages into the novel, the first portion being consumed with the living Wycks bizarre behavior, in particular a strange malady he appears to be suffering from, which would seem to contradict his oft-repeated claims that hes never been sick a day in my life. ...
http://thebedlamfiles.com/fiction/the-cadaver-of-gideon-wyck/
Century of Gideon - Washington TimesCentury of Gideon - Washington Times
Long before cable television, spa treatments and eco-friendly soaps and shampoos became staples in hotel rooms, there was the Bible -- the Gideon Bible.
https://www.washingtontimes.com/news/2009/jan/08/century-of/
FDA approves sorafenib for thyroid carcinoma | American Thyroid AssociationFDA approves sorafenib for thyroid carcinoma | American Thyroid Association
In collaboration with the Food and Drug Administration (FDA), and as a service to our members, ATA will provide updates on recent FDA approvals and other important FDA actions (e.g., updated safety information, new prescribing information) pertaining to therapies for cancer patients. This will allow the agency to inform oncologists and professionals in oncology-related fields in a timely manner. Included in the email from the FDA will be a link to the product label or to other sites for additional relevant clinical information. The following is a message from the FDAs Office of Hematology and Oncology Products Director, Dr. Richard Pazdur:. On November 22, 2013, the U. S. Food and Drug Administration approved sorafenib (NEXAVAR® tablets, Bayer Healthcare Pharmaceuticals Inc.) for the treatment of locally recurrent or metastatic, progressive, differentiated thyroid carcinoma (DTC) refractory to radioactive iodine treatment. Sorafenib was previously approved for treatment of renal cell carcinoma ...
https://www.thyroid.org/fda-approves-sorafenib-for-thyroid-carcinoma/
Eisai | SDG GroupEisai | SDG Group
Nihon Eisai Co. Ltd. is a Japanese pharmaceutical company established in 1941. In 1944, merger with Sakuragaoka Research Laboratory resulted in creation of Eisai Co. Ltd. The American subsidiary of the company, Eisai Inc., was established in 1995.. In 1996, Eisai received approval from the United States Food and Drug Administration (USFDA) for Aricept (donepezil), a drug discovered in the companys labs and co-marketed with Pfizer. Three years later in 1999, the company received USFDA approval for Aciphex (rabeprazole), a drug co-marketed with Johnson & Johnson.. In September 2006, the company acquired four oncology products from Ligand Pharmaceuticals. In April 2007, Eisai acquired Exton, Pennsylvania-based Morphotek, a company developing therapeutic monoclonal antibodies for the treatment of cancer, rheumatoid arthritis, and infectious diseases.. In December 2007, Eisai acquired MGI Pharma, a company specializing in oncology, for $3.9 billion USD. This event brought Dacogen (decitabine), Aloxi ...
http://www.sdggroup.com/es/about-sdg/customers/eisai
FDA Approves New Treatment for Adults With Mantle Cell Lymphoma - The ASCO PostFDA Approves New Treatment for Adults With Mantle Cell Lymphoma - The ASCO Post
The U.S. Food and Drug Administration (FDA) today granted accelerated approval to acalabrutinib (Calquence) for the treatment of adults with mantle cell lymphoma who have received at least one prior therapy. Mantle cell lymphoma is a particularly aggressive cancer, said Richard Pazdur, MD, Director of the FDAs Oncology Center of Excellence and Acting Director of the Office of Hematology and Oncology Products in the FDAs Center for Drug Evaluation and Research. For patients who have not responded to treatment or have relapsed, [acalabrutinib] provides a new treatment option that has shown high rates of response for some patients in initial studies.. Acalabrutinib is a kinase inhibitor that works by blocking an enzyme needed by the cancer to multiply and spread. The drug was approved using the Accelerated Approval pathway, under which the FDA may approve drugs for serious conditions where there is unmet medical need and a drug is shown to have certain effects that are reasonably likely to ...
https://www.ascopost.com/News/58210
H3 Biomedicine To Present 2018 Outlook at the 36th Annual J.P. Morgan Healthcare Conference | H3 BiomedicineH3 Biomedicine To Present 2018 Outlook at the 36th Annual J.P. Morgan Healthcare Conference | H3 Biomedicine
Cambridge, Mass., January 9, 2018 - H3 Biomedicine Inc., a clinical stage biopharmaceutical company specializing in the discovery and development of next generation cancer medicines using its data science and precision chemistry product engine, today announced that it will outline its key 2018 strategies and goals that build upon its success in advancing three differentiated, internally generated cancer therapies into clinical trials. Markus Warmuth, M.D., President and CEO of H3 Biomedicine, will provide an overview of the company and further details on its 2018 goals during its presentation at the 36th Annual J.P. Morgan Healthcare Conference on Thursday, January 11, 2017, at 9:00 a.m. PST in the Elizabethan D conference room at the Westin St. Francis Hotel in San Francisco.. Over the past six years, we built a leading oncology product engine at the interface of data science and precision chemistry with the goal of discovering cancer therapies that address molecular traits driving cancer in ...
https://www.h3biomedicine.com/2018/01/08/h3-biomedicine-to-present-2018-outlook-at-the-36th-annual-j-p-morgan-healthcare-conference/?elqTrackId=f5483db7be3d4c02877046d776df8188
Adherex Initiates Asian Phase I/II Trial of Eniluracil in Liver Cancer | WebWireAdherex Initiates Asian Phase I/II Trial of Eniluracil in Liver Cancer | WebWire
Research Triangle Park, NC, September 28, 2006 - - Adherex Technologies Inc. (AMEX:ADH, TSX:AHX), a biopharmaceutical company with a broad portfolio of oncology products under development, today annou...
https://www.webwire.com/ViewPressRel.asp?aId=21257
How To Contact Wellcome OncologyHow To Contact Wellcome Oncology
Monday-Friday, 9 a.m.-9 p.m., EST The Glaxo Wellcome Inc. Patient Assistance Program for Oncology Products is designed to provide financially disadvantaged individuals rapid access to any Glaxo Wellcome Inc. marketed prescription medicine at no cost. Patients who cannot afford therapy and who are uninsured, do not qualify for publicly funded medication assistance programs, or are in the process of applying for such programs are potential candidates.. ...
http://www.meds.com/lung/navelbine/nvbguide/contact.html
Danny Pearson - Fluidic Protein DiscoveryDanny Pearson - Fluidic Protein Discovery
Payers were asked about general oncology product management, use of specific management tools today, management challenges, and expected use of specific management tools in 2020-2022. Management tools were segmented into traditional (used across many therapeutic categories), oncology-specific (used in oncology but not routinely used in other disease areas), and systemic (not product-specific but that affect the way services are provided and funded). Specific questions for managing the cost of care in non-small cell lung cancer (NSCLC) and chronic lymphocytic leukemia (CLL) were included in the survey. NSCLC and CLL were chosen because of their diverse clinical characteristics and the level of innovation in these disease areas. The survey was fielded from May 31, 2017, to June 15, 2017. Results consisted of simple descriptive statistical analysis weighted by the payers reported organizational covered lives.Payers were concerned with the high cost and budget impact of oncology drugs and ...
http://cyclofluidic.co.uk/author/info/
FDA approves new treatment for advanced pancreatic cancer - Healthcanal.com : Healthcanal.comFDA approves new treatment for advanced pancreatic cancer - Healthcanal.com : Healthcanal.com
According to the National Cancer Institute, there will be 48,960 new cases of pancreatic cancer diagnosed in the U.S. in 2015, and nearly the same number of deaths caused by the disease (40,560). Pancreatic cancer can be difficult to diagnose early and treatment options are limited, especially when the disease has spread to other parts of the body (metastatic disease) and surgery to remove the tumor is not possible.. Many FDA staff who review drug applications are clinicians as well, so its especially rewarding when we are able to expedite access to new treatments for patients with unmet needs, said Richard Pazdur, M.D., director of the Office of Hematology and Oncology Products in the FDAs Center for Drug Evaluation and Research. By using the Priority Review designation for the application for Onivyde, patients will have earlier access to a drug that helps extend survival.. The FDA granted Priority Review and orphan drug designations for Onivyde. Priority review status is granted to ...
https://www.healthcanal.com/cancers/68050-fda-approves-new-treatment-for-advanced-pancreatic-cancer.html
Caraco to acquire rights to several drugs from Forest Labs - Drug Store NewsCaraco to acquire rights to several drugs from Forest Labs - Drug Store News
OSI announced that it had purchased a 43-acre site in Ardsley, a community in the town of Greenburgh, N.Y., and would move 350 employees from Melville and Farmingdale, N.Y., Cedar Knolls, N.J., and Boulder, Colo., to the new campus in the second half of this year.. The past 10 years has been a remarkable journey as the company has successfully brought its first oncology product, Tarceva, to market and taken the business profitable, OSI CEO Colin Goddard said. Nonetheless, we have recognized that we will only truly capture the full strategic value of our oncology franchise if we simplify our business by bringing together all the elements of our U.S. operations onto a single site.. ...
https://www.drugstorenews.com/article/caraco-acquire-rights-several-drugs-forest-labs/?device=mobile
Ligand Pharmaceuticals Announces Second Quarter Results :: Ligand Pharmaceuticals, Inc. (LGND)Ligand Pharmaceuticals Announces Second Quarter Results :: Ligand Pharmaceuticals, Inc. (LGND)
SAN DIEGO--. Ligand Pharmaceuticals Incorporated (NASDAQ:LGND) (the Company or Ligand) today announced financial results for the three months ended June 30, 2007 and provided a business update.. Second Quarter Results. The Company sold its commercial oncology product line in October 2006 and sold the AVINZA(R) product line in February 2007. The results of operations related to these products have been reflected as discontinued operations for all reporting periods discussed below.. Total revenues for the second quarter of 2007 were $1.4 million, compared with $1.1 million for the second quarter of 2006. Royalty revenues for the 2007 second quarter were $1.4 million, compared with none for the 2006 second quarter. Collaborative research and development and other revenues for the second quarter of 2007 were none, compared with $1.1 million in the second quarter of 2006.. Operating costs and expenses for the second quarter of 2007 were $16.3 million, compared with $19.1 million for the same 2006 ...
https://www.ligand.com/news-events/press-releases/detail/59/ligand-pharmaceuticals-announces-second-quarter-results
NEOPROBE : Completes Senior Debt and Preferred Stock Exchanges | 4-TradersNEOPROBE : Completes Senior Debt and Preferred Stock Exchanges | 4-Traders
Neoprobe Corporation , a diversified developer of innovative biomedical surgical oncology products, today announced that Platinum-Montaur Life Sciences, LLC has agreed to... | juin 22, 2010
http://www.4-traders.com/NEOPROBE-69952/news/NEOPROBE-Completes-Senior-Debt-and-Preferred-Stock-Exchanges-13401945/
Most recent papers in the journal Insect Science | Read by QxMDMost recent papers in the journal Insect Science | Read by QxMD
Epigenetic gene control is maintained by chromatin-associated Polycomb group (PcG) and Trithorax group (TrxG) genes, which act antagonistically via the interplay between PcG and TrxG regulation to generate silenced or permissive transcriptional states. In this study, we searched for PcG/TrxG genes in 180 arthropod genomes, covering all the sequenced arthropod genomes at the time of conducting this study, to perform a global investigation of PcG/TrxG genes in a phylogenetic frame. Results of ancestral state reconstruction analysis revealed that the ancestor of arthropod species has an almost complete repertoire of PcG/TrxG genes, and most of these genes were seldom lost above order level ...
https://www.readbyqxmd.com/journal/41290
Formulations SearchFormulations Search
This exciting Hair and Scalp Serum features our Vital Hair & Scalp Complex, which has been developed to improve follicle health by improving the ability to anchor hair to the scalp, while also reducing hair loss. Additional claims include anti-inflammatory and anti-oxidant activity. ProCircul-8 enhances microcirculation around the hair follicle, thereby stimulating it. In conjunction with polyvinylpyrollidone, these two ingredients create a highly efficacious hair and scalp health serum which provides lightweight hold! Mikrokill™ COS protects the integrity of this formulation ...
https://personalcaremagazine.com/formulations-by-category/3/hair-styling?pageNumber=3
UC researchers host dozens of clinical trials to study new treatments for COVID-19 | University Of CincinnatiUC researchers host dozens of clinical trials to study new treatments for COVID-19 | University Of Cincinnati
Clinical trials are approved and reviewed in phases, says Kissela, who is also a UC Health physician. Phase I studies assess the safety of a drug or device. Phase II studies assess the efficacy of a drug or device. Phase III studies involve randomized and blind testing in several hundreds to several thousands of patients to assess the effectiveness of the drug or device, the benefits and the range of possible adverse reactions. Then FDA approval is sought followed by Phase IV studies, often called post marketing surveillance trials, which are conducted after a drug or device has been approved for consumer sale. [It is] compared to other drugs on the market; [we] monitor its long-term effectiveness and impact on a patients quality of life and determine cost-effectiveness.. When hydroxychloroquine was given to patients initially, there was no placebo or sugar pill control group. And there was no randomization, meaning Group A received the medication and Group B received nothing, in order to ...
https://www.uc.edu/news/articles/2020/04/n20908045.html
Study Results for IMPAACT P1078 Presented at CROI 2018. IMPAACT Network News | JHU Baltimore Washington India Clinical TrialsStudy Results for IMPAACT P1078 Presented at CROI 2018. IMPAACT Network News | JHU Baltimore Washington India Clinical Trials
The International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) Network is delighted to announce the presentation of the study results and important findings from IMPAACT P1078 (TB APPRISE), a phase IV, randomized, double-blind, placebo-controlled trial to evaluate the safety of immediate versus deferred isoniazid preventive therapy (IPT) among HIV-infected women in high tuberculosis (TB) incidence settings, at the 2018 annual Conference on Retroviruses and Opportunistic Infections (CROI) in Boston, Massachusetts. Access Full Article. ...
http://bwictu.jhu.edu/news/study-results-for-impaact-p1078-presented-at-croi-2018.-impaact-network-news/
Glossary of Terms | Aplastic Anemia & MDS International FoundationGlossary of Terms | Aplastic Anemia & MDS International Foundation
A type of research study that tests how a drug, medical device, or treatment approach works in people. There are several types of clinical trials. Treatment trials test new treatment options. Diagnostic trials test new ways to diagnose a disease. Screening trials test the best way to detect a disease or health problem. Quality of life (supportive care) trials study ways to improve the comfort of people with chronic illness. Prevention trials look for better ways to prevent disease in people who have never had the disease. Trials are in four phases. Phase I tests a new drug or treatment in a small group to see if it is safe. Phase II expands the study to a larger group of people to find out if it works. Phase III expands the study to an even larger group of people to compare it to the standard treatment for the disease; and Phase IV takes place after the drug or treatment has been licensed and marketed to find out the long-term impact of the new treatment.. ...
https://mail.aamds.org/glossary/terms
Search Clinical Trials | Vanderbilt-Ingram Cancer CenterSearch Clinical Trials | Vanderbilt-Ingram Cancer Center
This phase IV trial studies how well standard chemotherapy works in treating young patients with medulloblastoma or other central nervous system primitive neuro-ectodermal tumors. Drugs used in standard chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading ...
https://www.vicc.org/clinical-trials/search?cancer-type=Head-Neck&f%5B0%5D=drug_name%3ARadiation
Our Products || Health ProductsOur Products || Health Products
The FDA has determined that N115 has sufficient safety toxicology and clinical data to proceed with the multi-dose, extended use, clinical trials. Phase III/Phase IV studies will focus on Pulmonary Fibrosis, Unmet Needs, and COPD patients. On the basis of existing clinical data, EmphyCorp is confident that its Investigative New Drug, N115, can and will be used for maintenance or continuous treatment of patients over extended periods of time. The Company believes that N115 will set the standard in the pharmaceutical industry for the treatment of major pulmonary diseases.. EmphyCorp and EmphyCorp.com does not encourage the use of any illegal substances. Always consult your local physician before taking any medication. Medications described on our website are for informational purposes ONLY and must be prescribed by your primary physician and scheduled for pickup at your local pharmacy. We are not a pharmacy and do not sell any prescription medications through this website.. EmphyCorp Inc - ...
https://emphycorp.com/our-products/by,category_name?filter_product=0
Amgen - Clinical Trials - SynopsisAmgen - Clinical Trials - Synopsis
A Prospective, Phase IV, Open-Label, Multi-Center Study Evaluating Changes in Bone Marrow Morphology in Adult Subjects Receiving Romiplostim for the Treatment of Thrombocytopenia Associated with Immune (Idiopathic) Thrombocytopenia Purpura (ITP). ...
http://www.amgentrials.com/amgen/studylist.aspx?productid=7
SuraminSuramin
July 2017). "Low-dose suramin in autism spectrum disorder: a small, phase I/II, randomized clinical trial". Annals of Clinical ... Suramin contains six aromatic systems - four benzene rings, sandwiched by a pair of naphthalene moieties - plus four amide ... https://health.ucsd.edu/news/topics/Suramin-Autism/Pages/Q-and-A.aspx Zhang YL, Keng YF, Zhao Y, Wu L, Zhang ZY (May 1998). " ... Suramin has been studied in a mouse model of autism and in a small phase I/II human trial. "Suramin Injection Advanced Patient ...
https://en.wikipedia.org/wiki/Suramin
CD1CD1
The group 2 (CD1d) ligand alpha-galactosylceramide is currently in phase I clinical trials for the treatment of advanced non- ... Current Topics in Microbiology and Immunology. 314: 27-50. doi:10.1007/978-3-540-69511-0_2. ISBN 978-3-540-69510-3. PMID ... typically represented by interferon-gamma and IL-4 production. ...
https://en.wikipedia.org/wiki/CD1
LY-404,039LY-404,039
In 2007, a randomized phase II clinical trial showed that LY-2140023 taken twice daily for 4 weeks improved schizophrenia ... However, a second, multicenter study reported four patients experiencing convulsions, suggesting a potential for increased risk ... Current Topics in Medicinal Chemistry. 8 (16): 1480-1. doi:10.2174/156802608786264209. PMID 19006848. Fraley ME (June 2009). " ... oral bioavailability in humans in a phase I clinical trial. A single dose of 200 mg results in an AUC value of 900 ng*h/ml. The ...
https://en.wikipedia.org/wiki/LY-404,039
Peter KrankePeter Kranke
... as well as qualifications with respect to the conduct of clinical trials (phase II to IV). The working group "clinical studies ... trials on postoperative nausea and vomiting and other issues in conjunction with perioperative medicine and associated topics. ... Among these trials, many studies were aiming to get a label for the indication of PONV prevention (phase II and III trials). ... Controlled Clinical Trials 2003; 24:736-51 C. C Apfel, P. Kranke, M. H. Katz, C. Goepfert, T. Papenfuss, S. Rauch, R. Heineck, ...
https://en.wikipedia.org/wiki/Peter_Kranke
Discovery and development of dipeptidyl peptidase-4 inhibitorsDiscovery and development of dipeptidyl peptidase-4 inhibitors
GSK suspended Phase III clinical trials in October 2008. Informations for this group of inhibitors are quite restricted. ... "Azetidine-Based Inhibitors of Dipeptidyl Peptidase IV (DPP IV)", Current Topics in Medicinal Chemistry, 7 (6): 597-608, doi: ... In January 2007 alogliptin was undergoing the phase III clinical trial and in October 2008 it was being reviewed by the U.S. ... In 2008 BI-1356 was undergoing phase III clinical trials; it was released as linagliptin in May 2011. X-ray crystallography has ...
https://en.wikipedia.org/wiki/Discovery_and_development_of_dipeptidyl_peptidase-4_inhibitors
Milos R. PopovicMilos R. Popovic
A randomized single-blind clinical trial", M. R. Popovic, N. Kapadia, V. Zivanovic, J. C. Furlan, B. C. Craven, and C. ... Pappas, I.P.I.; Popovic, M.R.; Keller, T.; Dietz, V.; Morari, M. (June 2001). "A reliable gait phase detection system". IEEE ... Topics in Spinal Cord Injury Rehabilitation. 14 (4): 62-68. doi:10.1310/sci1404-62. ISSN 1082-0744. Popovic, M.R.; Keller, T.; ... A Randomized Clinical Trial". Neurorehabilitation and Neural Repair. 25 (5): 433-442. doi:10.1177/1545968310392924. ISSN 1545- ...
https://en.wikipedia.org/wiki/Milos_R._Popovic
Nicholas Gonzalez (physician)Nicholas Gonzalez (physician)
A randomized phase III clinical trial for the possible treatment of pancreatic cancer with the Gonzalez Regimen was funded by a ... or Stage IV Pancreatic Cancer". clinicaltrials.gov. "Cancer's Enema No. 1? Make That 2", Wired, 30 October 2002 Chabot JA, Tsai ... and as a freelance writer, covering a variety of health-related topics, including a July 1972 cover story in New York Magazine ... What Went Wrong: The Truth Behind the Clinical Trial of the Enzyme Treatment of Cancer (2012, New Spring Press; ISBN 978-0- ...
https://en.wikipedia.org/wiki/Nicholas_Gonzalez_(physician)
Social inhibitionSocial inhibition
Another measure is the Behavioral Inhibition Observation System (BIOS). In clinical trials this measure is to be used for ... The point of this phase is to get an individual talking no matter how ridiculous or trivial it may seem. Phase two is about ... In one study, Fox and colleagues found that even at four months of age some infants had negative responses to unfamiliar visual ... An individual should not go over board using them; additionally there are times when initiating some conversation topics and ...
https://en.wikipedia.org/wiki/Social_inhibition
SetanaxibSetanaxib
... a compound that failed to initiate clinical trials. Development of setanaxib candidate showed promise in Phase I clinical trial ... lonely Nox Inhibitor setanaxib should hamper the future of the concept of Nox inhibition which is not identified as a hot topic ... The effects of antioxidants or scavengers in clinical trials has always been very disappointing in human clinical trials in ... Overall, setanaxib showed sub-optimal data for two proof-of-concept phase 2 clinical trials that question the future of this ...
https://en.wikipedia.org/wiki/Setanaxib
Male contraceptiveMale contraceptive
Oct 1997). "Phase II clinical trial of a vas deferens injectable contraceptive for the male". Contraception. 56 (4): 245-50. ... http://www.plannedparenthood.org/health-topics/birth-control-4211.htm ,. *^ "Condom , Definition of Condom by Merriam-Webster" ... which has completed a small phase II clinical trial in humans in India)[4] and ultrasound (with results so far obtained in ... November 2003). "A clinical trial of 7α-methyl-19-nortestosterone implants for possible use as a long-acting contraceptive for ...
https://en.wikipedia.org/wiki/Male_contraceptive
Influenza pandemicInfluenza pandemic
Tables on the Clinical trials of pandemic influenza prototype vaccines. July 2009". WHO.int. Retrieved 19 January 2018.. ... Phase 6. In addition to the criteria defined in Phase 5, the same virus spreads from human-to-human in at least one other ... 2006). Influenza Virology: Current Topics. Caister Academic Press. ISBN 1-904455-06-9. [1].. ... The 1889-1890 and 1918-1919 flu pandemics each came in three or four waves of increasing lethality.[26] But within a wave, ...
https://en.wikipedia.org/wiki/Flu_pandemic
List of vaccine topicsList of vaccine topics
... placebo-controlled phase 2 clinical trial". The Lancet. 381 (9871): 1037-45. doi:10.1016/S0140-6736(12)61764-4. PMID 23352749. ... "Current Topics in Microbiology and Immunology. Current Topics in Microbiology and Immunology. 325: 361-382. doi:10.1007/978-3- ... "Epstein-Barr Virus Vaccine May Soon Enter Phase 3 Trial". Medscape Today. Retrieved April 24, 2013.. ... "Inferring Reasons for the Failure of Staphylococcus aureus Vaccines in Clinical Trials". Frontiers in Cellular and Infection ...
https://en.wikipedia.org/wiki/List_of_vaccine_topics
Nicholas Gonzalez (physician)Nicholas Gonzalez (physician)
Clinical trial[edit]. A randomized phase III clinical trial for the possible treatment of pancreatic cancer with the Gonzalez ... Gonzalez became interested in medical research, cancer research in particular, while covering these topics.[7] ... or Stage IV Pancreatic Cancer". clinicaltrials.gov.. ... What Went Wrong: The Truth Behind the Clinical Trial of the ... A review article from the Journal of Clinical Gastroenterology is cited that notes the clinical efficacy of coffee enemas has ...
https://en.wikipedia.org/wiki/Nicholas_Gonzalez_
DronabinolDronabinol
Phase 2B clinical trials were completed in 2017 for FDA approval for this indication. Dronabinol demonstrated analgesic ... "Cannabis and Cannabinoids (PDQ)". Cancer Topics. National Cancer Institute, U.S. Department of Health and Human Services. 2011- ... the World Health Organization Expert Committee on Drug Dependence recommended transferring THC to Schedule IV of the Convention ... Clinical trials comparing the use of cannabis extracts with Marinol in the treatment of cancer cachexia have demonstrated equal ...
https://en.wikipedia.org/wiki/Dronabinol
NMDA receptor modulatorNMDA receptor modulator
... a randomized Phase 2 clinical trial" (PDF). Nature Medicine. Nature Publishing Group. 13 (9): 1102-1107. doi:10.1038/nm1632. ... http://www.esi-topics.com/schizophrenia/interviews/Dr-Daniel-Javitt.html http://archpsyc.ama-assn.org/cgi/content/abstract/56/1 ... NMDA receptor modulators (glutamate modulators) are a new form of antipsychotic that are in Phase II FDA study. The first ... P o 0.001 at week 4). Notably, patients treated with LY2140023 did not differ from placebo-treated patients with respect to ...
https://en.wikipedia.org/wiki/NMDA_receptor_modulator
Hantavirus vaccineHantavirus vaccine
List of vaccine topics. *#WHO-EM. *‡Withdrawn from market. *Clinical trials: *†Phase III ... "Phase 2a Immunogenicity Study of Hantaan/Puumala Virus DNA Vaccine for Prevention of Hemorrhagic Fever". ClinicalTrials.gov. ... In addition to Hantavax three more vaccine candidates have been studied in I-II stage clinical trials. They include a ... Field trial of an inactivated vaccine against hemorrhagic fever with renal syndrome in humans. Arch Virol. 1990;1(Suppl):35-47. ...
https://en.wikipedia.org/wiki/Hantavirus_vaccine
Multiple chemical sensitivityMultiple chemical sensitivity
No evidence based on well-controlled clinical trials is available that supports a cause-and-effect relationship between ... "Safety and Health Topics , Multiple Chemical Sensitivities". Osha.gov. Retrieved 2014-06-08.. ... Phase 1 report. Toronto, Ontario: Ministry of Health and Long-Term Care; 2017.p.17 ... and the 1999 Japanese definition requires one or more of four major symptoms - headaches; malaise and fatigue; muscle pain; ...
https://en.wikipedia.org/wiki/Multiple_chemical_sensitivity
Zika virusZika virus
In March 2017, a DNA vaccine was approved for phase-2 clinical trials. This vaccine consists of a small, circular piece of DNA ... "Aedes aegypti". Health Topics: Vectors: Mosquitos. European Centre for Disease Protection and Control. Retrieved 25 January ... and genetic evidence suggests they survived at least four consecutive winters in the region. The study authors conclude that ... "Phase 2 Zika vaccine trial begins in U.S., Central and South America". National Institutes of Health (NIH). 31 March 2017. ...
https://en.wikipedia.org/wiki/Zika_virus
Fatty acid amide hydrolaseFatty acid amide hydrolase
"Janssen Research & Development, LLC Voluntarily Suspends Dosing in Phase 2 Clinical Trials of Experimental Treatment for Mood ... Current Topics in Medicinal Chemistry. 10 (8): 828-58. doi:10.2174/156802610791164238. PMID 20370710. Khanna IK, Alexander CW ( ... at ClinicalTrials.gov "Clinical trials for SSR411298". EU Clinical Trials Register. Hart T, Macias AT, Benwell K, Brooks T, ... failed in clinical trials against osteoarthritis PF-04862853 RN-450 SA-47 SA-73 SSR-411298 well tolerated in clinical trials ...
https://en.wikipedia.org/wiki/Fatty_acid_amide_hydrolase
DeramciclaneDeramciclane
Successful pre-clinical, Phase I, and Phase II trials looked promising to the company and its investors even up until the third ... over four weeks of administration, and is unaffected by dose.[8][14] The oral tablet of deramciclane yields a bioavailability ... though it is a topic of debate.[8][14] ... No severe side effects were reported in any clinical trial, and ... was discontinued during Phase III trials due to clinically insignificant results compared to placebo groups.[11] ...
https://en.m.wikipedia.org/wiki/Deramciclane
Cold Spring Harbor LaboratoryCold Spring Harbor Laboratory
"ISIS initiates Phase 3 clinical trials for potential SMA therapy ISIS-SMNrx". The SMA Trust.. ... Topics. *Contributing property. *Keeper of the Register. *Historic district. *History of the National Register of Historic ... develop a new clinical cancer research unit at Northwell Health in Lake Success, NY, to support early-phase clinical studies of ... In 2014, Phase 3 trials begin for drug to treat spinal muscular atrophy (SMA), a neurodegenerative disease, based on Adrian ...
https://en.wikipedia.org/wiki/Cold_Spring_Harbor_Laboratory
Epstein-Barr virus-associated lymphoproliferative diseasesEpstein-Barr virus-associated lymphoproliferative diseases
Preparations of the monoclonal antibody directed against PD-L1 have given encouraging results in small clinical trials on ... phase that allows it to infect other lymphoid cells or expresses genes that suppress the lytic cycle and impose one of four ... Skalsky RL, Cullen BR (2015). "EBV Noncoding RNAs". Epstein Barr Virus Volume 2. Current Topics in Microbiology and Immunology ... At any time thereafter, however, the virus may reactivate, enter either its lytic cycle, latency phase II, or latency phase III ...
https://en.wikipedia.org/wiki/Epstein–Barr_virus-associated_lymphoproliferative_diseases
United States Military HIV Research ProgramUnited States Military HIV Research Program
Preliminary data from a phase 1 clinical trial indicate that 92% of participants would be protected from Zika infection. "HJF ... Blank C (November 30, 2016). "Human trials of Zika vaccine underway". Drug Topics. "Human Trials Begin for Army-Developed Zika ... a phase 1b, randomised, double-blind, placebo-controlled clinical trial". Lancet. 385 (9977): 1545-54. doi:10.1016/S0140-6736( ... phase 1, randomised, double-blind, placebo-controlled clinical trials". The Lancet. 391 (10120): 563-571. doi:10.1016/S0140- ...
https://en.wikipedia.org/wiki/United_States_Military_HIV_Research_Program
MuscimolMuscimol
... went under clinical trial phase I for epilepsy, but the trial was discontinued. Muscimol is one of the psychoactive ... In higher doses (2 mg/kg via IV), the EEG will show characteristic spikes. The effects of the muscimol begin 30-120 minutes ... Current Topics in Medicinal Chemistry. 2 (8): 817-32. doi:10.2174/1568026023393525. PMID 12171573. Quirk, K.; Whiting, P. J.; ... The Journal of Clinical Endocrinology and Metabolism. 47 (6): 1348-51. doi:10.1210/jcem-47-6-1348. PMID 162520. Carolis, A. ...
https://en.wikipedia.org/wiki/Muscimol
LipidLipid
The science and the clinical trials". Nutrition and Health. 20 (1): 11-20. doi:10.1177/026010600902000102. PMID 19326716.. ... Phase behavior is an area of study within biophysics and is the subject of current[when?] academic research.[61][62] Micelles ... The carbon chain, typically between four and 24 carbons long,[21] may be saturated or unsaturated, and may be attached to ... Current Topics in Medicinal Chemistry. 8 (8): 639-53. doi:10.2174/156802608784221479. PMID 18473889.. ...
https://en.wikipedia.org/wiki/Lipid
VirusVirus
... developed using viral vectors and a number of pharmaceutical proteins are currently in pre-clinical and clinical trials.[243] ... IV: (+)ssRNA viruses (+ strand or sense) RNA (e.g. Picornaviruses, Togaviruses). *V: (−)ssRNA viruses (− strand or antisense) ... Current Topics in Microbiology and Immunology. 2008;325:263-79. doi:10.1007/978-3-540-77349-8_15. PMID 18637511. ... Mawar N, Saha S, Pandit A, Mahajan U. The third phase of HIV pandemic: social consequences of HIV/AIDS stigma & discrimination ...
https://en.m.wikipedia.org/wiki/Viruses
Microbicides for sexually transmitted diseasesMicrobicides for sexually transmitted diseases
See Carrageenan#Medical Uses The phase III clinical trial for carrageenan-based Carraguard showed that it had no statistical ... World Health Organization (2002). "HIV/AIDS Topics: Microbicides". Geneva: World Health Organization. Retrieved August 28, 2006 ... Several different gel formulations are currently undergoing testing in phase III clinical efficacy trials, and about two dozen ... have failed to demonstrate efficacy in preventing HIV transmission in phase III clinical multicenter trials. PRO 2000 was ...
https://en.wikipedia.org/wiki/Microbicides_for_sexually_transmitted_diseases
Anterior cruciate ligament reconstructionAnterior cruciate ligament reconstruction
"ACL Program - Bridge-Enhanced ACL Repair (BEAR) Clinical Trial". www.childrenshospital.org. Retrieved 25 April 2016.. ... Phase 2[edit]. Many of the goals from phase I will be continued to the following phases until they have been reached. Some of ... After four months, more intense activities such as running are possible without risk. After five months, light ball work may ... "Anterior Cruciate Ligament (ACL) Injuries - Topic Overview". www.webmd.com. Retrieved 25 April 2016.. ...
https://en.wikipedia.org/wiki/Anterior_cruciate_ligament_reconstruction
List of Guidances for Statistics in Regulatory AffairsList of Guidances for Statistics in Regulatory Affairs
EMA/CHMP/539146/2013 Investigation of subgroups in confirmatory clinical trials *^ a b FDA - Clinical trial endpoints for the ... References classified by statistical topic[edit]. Good clinical practice[edit]. *ICH E6(R2): Good clinical practice [1] is an ... the use of meta-analysis and the use of only a single pivotal study in phase III clinical development. ... ICH E10 - Choice of control group in clinical trials *^ CHMP/EWP/2459/02 Methodological issues in confirmatory clinical trials ...
https://en.wikipedia.org/wiki/List_of_Guidances_for_Statistics_in_Regulatory_Affairs
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Oncology
Oncology1
  • It's been a great opportunity and a great learning experience for me as we look at the role of updating generic labels in oncology," said Harvey, director of the Phase I Clinical Trials Program atthe Winship Cancer Institute of Emory University. (aacr.org)
Phase IV - Contract Pharma
Phase IV - Contract Pharma (contractpharma.com)
Penile Cancer Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Adventist HealthCare
Penile Cancer Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Adventist HealthCare (adventisthealthcare.com)
Efficacy assessment of a new clotting factor concentrate in haemophilia A patients, including prophylactic treatment. - Surrey...
Efficacy assessment of a new clotting factor concentrate in haemophilia A patients, including prophylactic treatment. - Surrey... (epubs.surrey.ac.uk)
Acute Renal Failure With Uloric Reported Almost 6 Times More Frequently Compared To Some Other Gout Drugs - Drug Injury Watch
Acute Renal Failure With Uloric Reported Almost 6 Times More Frequently Compared To Some Other Gout Drugs - Drug Injury Watch (drug-injury.com)
A Phase II Study of Irinotecan for Patients with Previously Treated Small-Cell Lung Cancer.
A Phase II Study of Irinotecan for Patients with Previously Treated Small-Cell Lung Cancer. (bioportfolio.com)
Articles that mention Srinivas R. Sadda -Optical Coherence Tomography News
Articles that mention Srinivas R. Sadda -Optical Coherence Tomography News (octnews.org)
Stage iv cervix cancer drug therapy 2000:2010[pubdate] *count=100 - BioMedLib™ search engine
Stage iv cervix cancer drug therapy 2000:2010[pubdate] *count=100 - BioMedLib™ search engine (bmlsearch.com)
Renal failure reported more often with allopurinol, febuxostat
Renal failure reported more often with allopurinol, febuxostat (healio.com)
These highlights do not include all the information needed to use ANORO ELLIPTA safely and effectively. See full prescribing...
These highlights do not include all the information needed to use ANORO ELLIPTA safely and effectively. See full prescribing... (bioportfolio.com)
A New Era Of Innovation At DATATRAK Spurs Internal Growth
A "New Era Of Innovation" At DATATRAK Spurs Internal Growth (medindia.net)
Unfolding: Gemcitabine + Abraxane + Cisplatin for Stage 4 Pancreatic Cancer - Pancreatica
Unfolding: Gemcitabine + Abraxane + Cisplatin for Stage 4 Pancreatic Cancer - Pancreatica (pancreatica.org)
Pancreatic Cancer Blog, Pancreatica Blog, Gemcitabine, 5-FU, Fluorouracil, Capecitabine, FOLFIRINOX, Abraxane, Tarceva, Gemzar ...
Pancreatic Cancer Blog, Pancreatica Blog, Gemcitabine, 5-FU, Fluorouracil, Capecitabine, FOLFIRINOX, Abraxane, Tarceva, Gemzar ... (pancreatica.org)
Nine IV compounds in development for resistant gram-negative bacilli
Nine IV compounds in development for resistant gram-negative bacilli (healio.com)
Gabapentin Watch
Gabapentin Watch (tuum-est.net)
Phase III trial shows crizotinib superior to single-agent chemotherapy for ALK-positive advanced NSCLC | ESMO
Phase III trial shows crizotinib superior to single-agent chemotherapy for ALK-positive advanced NSCLC | ESMO (esmo.org)
Lu, J.<...
Lu, J.<... (profiles.wustl.edu)
Medicina Muncii Cluj-Napoca :: Topic: 1zdj How To Purchase Coreg Without A Prescription, (1/1)
Medicina Muncii Cluj-Napoca :: Topic: 1zdj How To Purchase Coreg Without A Prescription, (1/1) (medicinamuncii-cluj.ro)
Clinical Trials, Phase II as Topic | Profiles RNS
Clinical Trials, Phase II as Topic | Profiles RNS (profiles.umassmed.edu)
ONLINE FEATURE | Ototoxicity of FDA-Approved Drugs Being Re-Purposed for COVID-19 Treatment | Audiology
ONLINE FEATURE | Ototoxicity of FDA-Approved Drugs Being Re-Purposed for COVID-19 Treatment | Audiology (audiology.org)
Cempra Completes Enrollment of Phase 2 Portion of Phase 2/3 Clinical Trial of TAKSTA(TM) (CEM-102 or Sodium Fusidate) for...
Cempra Completes Enrollment of Phase 2 Portion of Phase 2/3 Clinical Trial of TAKSTA(TM) (CEM-102 or Sodium Fusidate) for... (medindia.net)
Adherence to prescribed antihypertensive drug treatments: longitudinal study of electronically compiled dosing histories | The...
Adherence to prescribed antihypertensive drug treatments: longitudinal study of electronically compiled dosing histories | The... (bmj.com)
Challenges and Considerations in Clinical Development of Targeted Therapies: AML as a Case Study
Challenges and Considerations in Clinical Development of "Targeted Therapies": AML as a Case Study (xtalks.com)
Clinical trial transparency: 'There is no one answer to what must be disclosed'
Clinical trial transparency: 'There is no one answer to what must be disclosed' (outsourcing-pharma.com)
The CONSENSUS study: protocol for a mixed methods study to establish which outcomes should be included in a core outcome set...
The CONSENSUS study: protocol for a mixed methods study to establish which outcomes should be included in a core outcome set... (trialsjournal.biomedcentral.com)
Getting Treatment Options to Rare Disease Patients Faster: Putting Patients First in Clinical Trials
Getting Treatment Options to Rare Disease Patients Faster: Putting Patients First in Clinical Trials (xtalks.com)
Pharmaceutical companies' policies on access to trial data, results, and methods: audit study | The BMJ
Pharmaceutical companies' policies on access to trial data, results, and methods: audit study | The BMJ (bmj.com)