Clinical Trials as Topic: Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.Clinical Trials, Phase III as Topic: Works about comparative studies to verify the effectiveness of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques determined in phase II studies. During these trials, patients are monitored closely by physicians to identify any adverse reactions from long-term use. These studies are performed on groups of patients large enough to identify clinically significant responses and usually last about three years. This concept includes phase III studies conducted in both the U.S. and in other countries.Clinical Trials, Phase II as Topic: Works about studies that are usually controlled to assess the effectiveness and dosage (if appropriate) of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques. These studies are performed on several hundred volunteers, including a limited number of patients with the target disease or disorder, and last about two years. This concept includes phase II studies conducted in both the U.S. and in other countries.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Clinical Trials, Phase I as Topic: Works about studies performed to evaluate the safety of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques in healthy subjects and to determine the safe dosage range (if appropriate). These tests also are used to determine pharmacologic and pharmacokinetic properties (toxicity, metabolism, absorption, elimination, and preferred route of administration). They involve a small number of persons and usually last about 1 year. This concept includes phase I studies conducted both in the U.S. and in other countries.Research Design: A plan for collecting and utilizing data so that desired information can be obtained with sufficient precision or so that an hypothesis can be tested properly.Controlled Clinical Trials as Topic: Works about clinical trials involving one or more test treatments, at least one control treatment, specified outcome measures for evaluating the studied intervention, and a bias-free method for assigning patients to the test treatment. The treatment may be drugs, devices, or procedures studied for diagnostic, therapeutic, or prophylactic effectiveness. Control measures include placebos, active medicines, no-treatment, dosage forms and regimens, historical comparisons, etc. When randomization using mathematical techniques, such as the use of a random numbers table, is employed to assign patients to test or control treatments, the trials are characterized as RANDOMIZED CONTROLLED TRIALS AS TOPIC.Double-Blind Method: A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.Randomized Controlled Trials as Topic: Works about clinical trials that involve at least one test treatment and one control treatment, concurrent enrollment and follow-up of the test- and control-treated groups, and in which the treatments to be administered are selected by a random process, such as the use of a random-numbers table.Patient Selection: Criteria and standards used for the determination of the appropriateness of the inclusion of patients with specific conditions in proposed treatment plans and the criteria used for the inclusion of subjects in various clinical trials and other research protocols.Multicenter Studies as Topic: Works about controlled studies which are planned and carried out by several cooperating institutions to assess certain variables and outcomes in specific patient populations, for example, a multicenter study of congenital anomalies in children.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Clinical Trials, Phase IV as Topic: Planned post-marketing studies of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques that have been approved for general sale. These studies are often conducted to obtain additional data about the safety and efficacy of a product. This concept includes phase IV studies conducted in both the U.S. and in other countries.Placebos: Any dummy medication or treatment. Although placebos originally were medicinal preparations having no specific pharmacological activity against a targeted condition, the concept has been extended to include treatments or procedures, especially those administered to control groups in clinical trials in order to provide baseline measurements for the experimental protocol.Clinical Trials Data Monitoring Committees: Committees established to review interim data and efficacy outcomes in clinical trials. The findings of these committees are used in deciding whether a trial should be continued as designed, changed, or terminated. Government regulations regarding federally-funded research involving human subjects (the "Common Rule") require (45 CFR 46.111) that research ethics committees reviewing large-scale clinical trials monitor the data collected using a mechanism such as a data monitoring committee. FDA regulations (21 CFR 50.24) require that such committees be established to monitor studies conducted in emergency settings.Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.Clinical Protocols: Precise and detailed plans for the study of a medical or biomedical problem and/or plans for a regimen of therapy.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Evidence-Based Medicine: An approach of practicing medicine with the goal to improve and evaluate patient care. It requires the judicious integration of best research evidence with the patient's values to make decisions about medical care. This method is to help physicians make proper diagnosis, devise best testing plan, choose best treatment and methods of disease prevention, as well as develop guidelines for large groups of patients with the same disease. (from JAMA 296 (9), 2006)Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Single-Blind Method: A method in which either the observer(s) or the subject(s) is kept ignorant of the group to which the subjects are assigned.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Antineoplastic Agents: Substances that inhibit or prevent the proliferation of NEOPLASMS.Early Termination of Clinical Trials: Earlier than planned termination of clinical trials.Congresses as Topic: Conferences, conventions or formal meetings usually attended by delegates representing a special field of interest.United StatesDrug Therapy, Combination: Therapy with two or more separate preparations given for a combined effect.Drug Administration Schedule: Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.Sample Size: The number of units (persons, animals, patients, specified circumstances, etc.) in a population to be studied. The sample size should be big enough to have a high likelihood of detecting a true difference between two groups. (From Wassertheil-Smoller, Biostatistics and Epidemiology, 1990, p95)Pilot Projects: Small-scale tests of methods and procedures to be used on a larger scale if the pilot study demonstrates that these methods and procedures can work.Quality of Life: A generic concept reflecting concern with the modification and enhancement of life attributes, e.g., physical, political, moral and social environment; the overall condition of a human life.Review Literature as Topic: Published materials which provide an examination of recent or current literature. Review articles can cover a wide range of subject matter at various levels of completeness and comprehensiveness based on analyses of literature that may include research findings. The review may reflect the state of the art. It also includes reviews as a literary form.Guidelines as Topic: A systematic statement of policy rules or principles. Guidelines may be developed by government agencies at any level, institutions, professional societies, governing boards, or by convening expert panels. The text may be cursive or in outline form but is generally a comprehensive guide to problems and approaches in any field of activity. For guidelines in the field of health care and clinical medicine, PRACTICE GUIDELINES AS TOPIC is available.Research Subjects: Persons who are enrolled in research studies or who are otherwise the subjects of research.Biomedical Research: Research that involves the application of the natural sciences, especially biology and physiology, to medicine.Questionnaires: Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. The term is often applied to a self-completed survey instrument.Outcome Assessment (Health Care): Research aimed at assessing the quality and effectiveness of health care as measured by the attainment of a specified end result or outcome. Measures include parameters such as improved health, lowered morbidity or mortality, and improvement of abnormal states (such as elevated blood pressure).Meta-Analysis as Topic: A quantitative method of combining the results of independent studies (usually drawn from the published literature) and synthesizing summaries and conclusions which may be used to evaluate therapeutic effectiveness, plan new studies, etc., with application chiefly in the areas of research and medicine.Patient Education as Topic: The teaching or training of patients concerning their own health needs.Cost-Benefit Analysis: A method of comparing the cost of a program with its expected benefits in dollars (or other currency). The benefit-to-cost ratio is a measure of total return expected per unit of money spent. This analysis generally excludes consideration of factors that are not measured ultimately in economic terms. Cost effectiveness compares alternative ways to achieve a specific set of results.Abstracting and Indexing as Topic: Activities performed to identify concepts and aspects of published information and research reports.Severity of Illness Index: Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.Practice Guidelines as Topic: Directions or principles presenting current or future rules of policy for assisting health care practitioners in patient care decisions regarding diagnosis, therapy, or related clinical circumstances. The guidelines may be developed by government agencies at any level, institutions, professional societies, governing boards, or by the convening of expert panels. The guidelines form a basis for the evaluation of all aspects of health care and delivery.Combined Modality Therapy: The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.Antineoplastic Combined Chemotherapy Protocols: The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.Endpoint Determination: Establishment of the level of a quantifiable effect indicative of a biologic process. The evaluation is frequently to detect the degree of toxic or therapeutic effect.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Informed Consent: Voluntary authorization, by a patient or research subject, with full comprehension of the risks involved, for diagnostic or investigative procedures, and for medical and surgical treatment.Textbooks as Topic: Books used in the study of a subject that contain a systematic presentation of the principles and vocabulary of a subject.Administration, Oral: The giving of drugs, chemicals, or other substances by mouth.Survival Analysis: A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.Reproducibility of Results: The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.Research Support as Topic: Financial support of research activities.Risk Assessment: The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)Patient Compliance: Voluntary cooperation of the patient in following a prescribed regimen.Medical Oncology: A subspecialty of internal medicine concerned with the study of neoplasms.Breast Neoplasms: Tumors or cancer of the human BREAST.Drugs, Investigational: Drugs which have received FDA approval for human testing but have yet to be approved for commercial marketing. This includes drugs used for treatment while they still are undergoing clinical trials (Treatment IND). The main heading includes drugs under investigation in foreign countries.Placebo Effect: An effect usually, but not necessarily, beneficial that is attributable to an expectation that the regimen will have an effect, i.e., the effect is due to the power of suggestion.Patient Participation: Patient involvement in the decision-making process in matters pertaining to health.Recurrence: The return of a sign, symptom, or disease after a remission.Data Interpretation, Statistical: Application of statistical procedures to analyze specific observed or assumed facts from a particular study.Prognosis: A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.Terminology as Topic: The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.Feasibility Studies: Studies to determine the advantages or disadvantages, practicability, or capability of accomplishing a projected plan, study, or project.Dietary Supplements: Products in capsule, tablet or liquid form that provide dietary ingredients, and that are intended to be taken by mouth to increase the intake of nutrients. Dietary supplements can include macronutrients, such as proteins, carbohydrates, and fats; and/or MICRONUTRIENTS, such as VITAMINS; MINERALS; and PHYTOCHEMICALS.Disease Progression: The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.Publishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.Pain Measurement: Scales, questionnaires, tests, and other methods used to assess pain severity and duration in patients or experimental animals to aid in diagnosis, therapy, and physiological studies.Drug Industry: That segment of commercial enterprise devoted to the design, development, and manufacture of chemical products for use in the diagnosis and treatment of disease, disability, or other dysfunction, or to improve function.Benchmarking: Method of measuring performance against established standards of best practice.Interviews as Topic: Conversations with an individual or individuals held in order to obtain information about their background and other personal biographical data, their attitudes and opinions, etc. It includes school admission or job interviews.Survival Rate: The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.Disease-Free Survival: Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.United States Food and Drug Administration: An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.Drug Evaluation: Any process by which toxicity, metabolism, absorption, elimination, preferred route of administration, safe dosage range, etc., for a drug or group of drugs is determined through clinical assessment in humans or veterinary animals.Drug Approval: Process that is gone through in order for a drug to receive approval by a government regulatory agency. This includes any required pre-clinical or clinical testing, review, submission, and evaluation of the applications and test results, and post-marketing surveillance of the drug.Stroke: A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)Cross-Over Studies: Studies comparing two or more treatments or interventions in which the subjects or patients, upon completion of the course of one treatment, are switched to another. In the case of two treatments, A and B, half the subjects are randomly allocated to receive these in the order A, B and half to receive them in the order B, A. A criticism of this design is that effects of the first treatment may carry over into the period when the second is given. (Last, A Dictionary of Epidemiology, 2d ed)HIV Infections: Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS).Exercise Therapy: A regimen or plan of physical activities designed and prescribed for specific therapeutic goals. Its purpose is to restore normal musculoskeletal function or to reduce pain caused by diseases or injuries.Random Allocation: A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects.Patient Satisfaction: The degree to which the individual regards the health care service or product or the manner in which it is delivered by the provider as useful, effective, or beneficial.Therapeutic Human Experimentation: Human experimentation that is intended to benefit the subjects on whom it is performed.Intention to Treat Analysis: Strategy for the analysis of RANDOMIZED CONTROLLED TRIALS AS TOPIC that compares patients in the groups to which they were originally randomly assigned.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Cognitive Therapy: A direct form of psychotherapy based on the interpretation of situations (cognitive structure of experiences) that determine how an individual feels and behaves. It is based on the premise that cognition, the process of acquiring knowledge and forming beliefs, is a primary determinant of mood and behavior. The therapy uses behavioral and verbal techniques to identify and correct negative thinking that is at the root of the aberrant behavior.Biological Markers: Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Drug Combinations: Single preparations containing two or more active agents, for the purpose of their concurrent administration as a fixed dose mixture.Infusions, Intravenous: The long-term (minutes to hours) administration of a fluid into the vein through venipuncture, either by letting the fluid flow by gravity or by pumping it.National Institutes of Health (U.S.): An operating division of the US Department of Health and Human Services. It is concerned with the overall planning, promoting, and administering of programs pertaining to health and medical research. Until 1995, it was an agency of the United States PUBLIC HEALTH SERVICE.Lung Neoplasms: Tumors or cancer of the LUNG.Phytotherapy: Use of plants or herbs to treat diseases or to alleviate pain.Bias (Epidemiology): Any deviation of results or inferences from the truth, or processes leading to such deviation. Bias can result from several sources: one-sided or systematic variations in measurement from the true value (systematic error); flaws in study design; deviation of inferences, interpretations, or analyses based on flawed data or data collection; etc. There is no sense of prejudice or subjectivity implied in the assessment of bias under these conditions.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Patient Dropouts: Discontinuance of care received by patient(s) due to reasons other than full recovery from the disease.Programmed Instruction as Topic: Instruction in which learners progress at their own rate using workbooks, textbooks, or electromechanical devices that provide information in discrete steps, test learning at each step, and provide immediate feedback about achievement. (ERIC, Thesaurus of ERIC Descriptors, 1996).Data Collection: Systematic gathering of data for a particular purpose from various sources, including questionnaires, interviews, observation, existing records, and electronic devices. The process is usually preliminary to statistical analysis of the data.Analysis of Variance: A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)National Cancer Institute (U.S.): Component of the NATIONAL INSTITUTES OF HEALTH. Through basic and clinical biomedical research and training, it conducts and supports research with the objective of cancer prevention, early stage identification and elimination. This Institute was established in 1937.Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.Research: Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)Antibodies, Monoclonal, Humanized: Antibodies from non-human species whose protein sequences have been modified to make them nearly identical with human antibodies. If the constant region and part of the variable region are replaced, they are called humanized. If only the constant region is modified they are called chimeric. INN names for humanized antibodies end in -zumab.Research Personnel: Those individuals engaged in research.Drug-Related Side Effects and Adverse Reactions: Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chemically-induced adverse conditions due to toxicity, DRUG INTERACTIONS, and metabolic effects of pharmaceuticals.Acute Disease: Disease having a short and relatively severe course.Chemotherapy, Adjuvant: Drug therapy given to augment or stimulate some other form of treatment such as surgery or radiation therapy. Adjuvant chemotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.Societies, Medical: Societies whose membership is limited to physicians.Drug Evaluation, Preclinical: Preclinical testing of drugs in experimental animals or in vitro for their biological and toxic effects and potential clinical applications.Statistics as Topic: The science and art of collecting, summarizing, and analyzing data that are subject to random variation. The term is also applied to the data themselves and to the summarization of the data.Predictive Value of Tests: In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.Treatment Failure: A measure of the quality of health care by assessment of unsuccessful results of management and procedures used in combating disease, in individual cases or series.Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.Great BritainHealth Knowledge, Attitudes, Practice: Knowledge, attitudes, and associated behaviors which pertain to health-related topics such as PATHOLOGIC PROCESSES or diseases, their prevention, and treatment. This term refers to non-health workers and health workers (HEALTH PERSONNEL).Kaplan-Meier Estimate: A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)Age Factors: Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.Immunotherapy: Manipulation of the host's immune system in treatment of disease. It includes both active and passive immunization as well as immunosuppressive therapy to prevent graft rejection.Safety: Freedom from exposure to danger and protection from the occurrence or risk of injury or loss. It suggests optimal precautions in the workplace, on the street, in the home, etc., and includes personal safety as well as the safety of property.Translational Medical Research: The application of discoveries generated by laboratory research and preclinical studies to the development of clinical trials and studies in humans. A second area of translational research concerns enhancing the adoption of best practices.EuropeDecision Making: The process of making a selective intellectual judgment when presented with several complex alternatives consisting of several variables, and usually defining a course of action or an idea.Infant, Newborn: An infant during the first month after birth.Counseling: The giving of advice and assistance to individuals with educational or personal problems.Pragmatic Clinical Trials as Topic: Works about randomized clinical trials that compare interventions in clinical settings and which look at a range of effectiveness outcomes and impacts.Cohort Studies: Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.Program Evaluation: Studies designed to assess the efficacy of programs. They may include the evaluation of cost-effectiveness, the extent to which objectives are met, or impact.Statistics, Nonparametric: A class of statistical methods applicable to a large set of probability distributions used to test for correlation, location, independence, etc. In most nonparametric statistical tests, the original scores or observations are replaced by another variable containing less information. An important class of nonparametric tests employs the ordinal properties of the data. Another class of tests uses information about whether an observation is above or below some fixed value such as the median, and a third class is based on the frequency of the occurrence of runs in the data. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1284; Corsini, Concise Encyclopedia of Psychology, 1987, p764-5)Molecular Targeted Therapy: Treatments with drugs which interact with or block synthesis of specific cellular components characteristic of the individual's disease in order to stop or interrupt the specific biochemical dysfunction involved in progression of the disease.Neoplasm Staging: Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.Herbals as Topic: Works about books, articles or other publications on herbs or plants describing their medicinal value.Canada: The largest country in North America, comprising 10 provinces and three territories. Its capital is Ottawa.Cardiovascular Diseases: Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.Publication Bias: The influence of study results on the chances of publication and the tendency of investigators, reviewers, and editors to submit or accept manuscripts for publication based on the direction or strength of the study findings. Publication bias has an impact on the interpretation of clinical trials and meta-analyses. Bias can be minimized by insistence by editors on high-quality research, thorough literature reviews, acknowledgement of conflicts of interest, modification of peer review practices, etc.Communication: The exchange or transmission of ideas, attitudes, or beliefs between individuals or groups.Anti-Bacterial Agents: Substances that reduce the growth or reproduction of BACTERIA.Motivation: Those factors which cause an organism to behave or act in either a goal-seeking or satisfying manner. They may be influenced by physiological drives or by external stimuli.Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)Ethics Committees, Research: Hospital or other institutional committees established to protect the welfare of research subjects. Federal regulations (the "Common Rule" (45 CFR 46)) mandate the use of these committees to monitor federally-funded biomedical and behavioral research involving human subjects.Models, Statistical: Statistical formulations or analyses which, when applied to data and found to fit the data, are then used to verify the assumptions and parameters used in the analysis. Examples of statistical models are the linear model, binomial model, polynomial model, two-parameter model, etc.Algorithms: A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.Incidence: The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.Genetic Therapy: Techniques and strategies which include the use of coding sequences and other conventional or radical means to transform or modify cells for the purpose of treating or reversing disease conditions.Recovery of Function: A partial or complete return to the normal or proper physiologic activity of an organ or part following disease or trauma.Anti-HIV Agents: Agents used to treat AIDS and/or stop the spread of the HIV infection. These do not include drugs used to treat symptoms or opportunistic infections associated with AIDS.Databases as Topic: Organized collections of computer records, standardized in format and content, that are stored in any of a variety of computer-readable modes. They are the basic sets of data from which computer-readable files are created. (from ALA Glossary of Library and Information Science, 1983)Ethics, Medical: The principles of professional conduct concerning the rights and duties of the physician, relations with patients and fellow practitioners, as well as actions of the physician in patient care and interpersonal relations with patient families.Human Experimentation: The use of humans as investigational subjects.Evaluation Studies as Topic: Studies determining the effectiveness or value of processes, personnel, and equipment, or the material on conducting such studies. For drugs and devices, CLINICAL TRIALS AS TOPIC; DRUG EVALUATION; and DRUG EVALUATION, PRECLINICAL are available.Conflict of Interest: A situation in which an individual might benefit personally from official or professional actions. It includes a conflict between a person's private interests and official responsibilities in a position of trust. The term is not restricted to government officials. The concept refers both to actual conflict of interest and the appearance or perception of conflict.Cancer Vaccines: Vaccines or candidate vaccines designed to prevent or treat cancer. Vaccines are produced using the patient's own whole tumor cells as the source of antigens, or using tumor-specific antigens, often recombinantly produced.National Institute on Drug Abuse (U.S.): Component of the NATIONAL INSTITUTES OF HEALTH. It supports a comprehensive research portfolio that focuses on the biological, social, behavioral and neuroscientific bases of drug abuse on the body and brain as well as its causes, prevention, and treatment. NIDA, NIAAA, and NIMH were created as coequal institutes within the Alcohol, Drug Abuse and Mental Health Administration in 1974. It was established within the NATIONAL INSTITUTES OF HEALTH in 1992.Anticoagulants: Agents that prevent clotting.Myocardial Infarction: NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).Behavior Therapy: The application of modern theories of learning and conditioning in the treatment of behavior disorders.Ethics, Research: The moral obligations governing the conduct of research. Used for discussions of research ethics as a general topic.International Cooperation: The interaction of persons or groups of persons representing various nations in the pursuit of a common goal or interest.Chi-Square Distribution: A distribution in which a variable is distributed like the sum of the squares of any given independent random variable, each of which has a normal distribution with mean of zero and variance of one. The chi-square test is a statistical test based on comparison of a test statistic to a chi-square distribution. The oldest of these tests are used to detect whether two or more population distributions differ from one another.Multivariate Analysis: A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.Proportional Hazards Models: Statistical models used in survival analysis that assert that the effect of the study factors on the hazard rate in the study population is multiplicative and does not change over time.Administration, Topical: The application of drug preparations to the surfaces of the body, especially the skin (ADMINISTRATION, CUTANEOUS) or mucous membranes. This method of treatment is used to avoid systemic side effects when high doses are required at a localized area or as an alternative systemic administration route, to avoid hepatic processing for example.Quality Control: A system for verifying and maintaining a desired level of quality in a product or process by careful planning, use of proper equipment, continued inspection, and corrective action as required. (Random House Unabridged Dictionary, 2d ed)Internationality: The quality or state of relating to or affecting two or more nations. (After Merriam-Webster Collegiate Dictionary, 10th ed)Drug Therapy: The use of DRUGS to treat a DISEASE or its symptoms. One example is the use of ANTINEOPLASTIC AGENTS to treat CANCER.Paclitaxel: A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized form leading to cell death.Comparative Effectiveness Research: Conduct and synthesis of systematic research comparing interventions and strategies to prevent, diagnose, treat, and monitor health conditions. The purpose of this research is to inform patients, providers, and decision-makers, responding to their expressed needs, about which interventions are most effective for which patients under specific circumstances. (hhs.gov/recovery/programs/cer/draftdefinition.html accessed 6/12/2009)Postoperative Complications: Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.Health Education: Education that increases the awareness and favorably influences the attitudes and knowledge relating to the improvement of health on a personal or community basis.Curriculum: A course of study offered by an educational institution.Pain Management: A form of therapy that employs a coordinated and interdisciplinary approach for easing the suffering and improving the quality of life of those experiencing pain.Bookplates as Topic: Labels pasted in books to mark their ownership and sometimes to indicate their location in a library. Private bookplates are often ornate or artistic: simpler and smaller ones bearing merely the owner's name are called "book labels." They are usually pasted on the front endpaper of books. (From Harrod, The Librarians' Glossary and Reference Book, 4th rev ed & Random House Unabridged Dictionary, 2d ed)Broadsides as Topic: Published pieces of paper or other material, usually printed on one side and intended to be read unfolded and usually intended to be posted, publicly distributed, or sold. (From Genre Terms: A Thesaurus for Use in Rare Book and Special Collections Cataloguing, 2d ed)Exercise: Physical activity which is usually regular and done with the intention of improving or maintaining PHYSICAL FITNESS or HEALTH. Contrast with PHYSICAL EXERTION which is concerned largely with the physiologic and metabolic response to energy expenditure.Risk Reduction Behavior: Reduction of high-risk choices and adoption of low-risk quantity and frequency alternatives.Smoking Cessation: Discontinuation of the habit of smoking, the inhaling and exhaling of tobacco smoke.Control Groups: Groups that serve as a standard for comparison in experimental studies. They are similar in relevant characteristics to the experimental group but do not receive the experimental intervention.Health Promotion: Encouraging consumer behaviors most likely to optimize health potentials (physical and psychosocial) through health information, preventive programs, and access to medical care.Databases, Factual: Extensive collections, reputedly complete, of facts and data garnered from material of a specialized subject area and made available for analysis and application. The collection can be automated by various contemporary methods for retrieval. The concept should be differentiated from DATABASES, BIBLIOGRAPHIC which is restricted to collections of bibliographic references.Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.Diabetes Mellitus, Type 2: A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.Magnetic Resonance Imaging: Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.MEDLINE: The premier bibliographic database of the NATIONAL LIBRARY OF MEDICINE. MEDLINE® (MEDLARS Online) is the primary subset of PUBMED and can be searched on NLM's Web site in PubMed or the NLM Gateway. MEDLINE references are indexed with MEDICAL SUBJECT HEADINGS (MeSH).Neoplasm Recurrence, Local: The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.Anti-Inflammatory Agents: Substances that reduce or suppress INFLAMMATION.Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Prostatic Neoplasms: Tumors or cancer of the PROSTATE.Regression Analysis: Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable.Australia: The smallest continent and an independent country, comprising six states and two territories. Its capital is Canberra.Health Care Costs: The actual costs of providing services related to the delivery of health care, including the costs of procedures, therapies, and medications. It is differentiated from HEALTH EXPENDITURES, which refers to the amount of money paid for the services, and from fees, which refers to the amount charged, regardless of cost.Therapeutic Equipoise: Expectation of real uncertainty on the part of the investigator regarding the comparative therapeutic merits of each arm in a trial.Physical Therapy Modalities: Therapeutic modalities frequently used in PHYSICAL THERAPY SPECIALTY by PHYSICAL THERAPISTS or physiotherapists to promote, maintain, or restore the physical and physiological well-being of an individual.Bibliometrics: The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)Individualized Medicine: Therapeutic approach tailoring therapy for genetically defined subgroups of patients.Drug Delivery Systems: Systems for the delivery of drugs to target sites of pharmacological actions. Technologies employed include those concerning drug preparation, route of administration, site targeting, metabolism, and toxicity.Drug Discovery: The process of finding chemicals for potential therapeutic use.Netherlands: Country located in EUROPE. It is bordered by the NORTH SEA, BELGIUM, and GERMANY. Constituent areas are Aruba, Curacao, Sint Maarten, formerly included in the NETHERLANDS ANTILLES.Attitude of Health Personnel: Attitudes of personnel toward their patients, other professionals, toward the medical care system, etc.Germany

Defining and analysing symptom palliation in cancer clinical trials: a deceptively difficult exercise. (1/13843)

The assessment of symptom palliation is an essential component of many treatment comparisons in clinical trials, yet an extensive literature search revealed no consensus as to its precise definition, which could embrace relief of symptoms, time to their onset, duration, degree, as well as symptom control and prevention. In an attempt to assess the importance of these aspects and to compare different methods of analysis, we used one symptom (cough) from a patient self-assessment questionnaire (the Rotterdam Symptom Checklist) in a large (>300 patient) multicentre randomized clinical trial (conducted by the Medical Research Council Lung Cancer Working Party) of palliative chemotherapy in small-cell lung cancer. The regimens compared were a two-drug regimen (2D) and a four-drug regimen (4D). No differences were seen between the regimens in time of onset of palliation or its duration. The degree of palliation was strongly related to the initial severity: 90% of the patients with moderate or severe cough at baseline reported improvement, compared with only 53% of those with mild cough. Analyses using different landmark time points gave conflicting results: the 4D regimen was superior at 1 month and at 3 months, whereas at 2 months the 2D regimen appeared superior. When improvement at any time up to 3 months was considered, the 4D regimen showed a significant benefit (4D 79%, 2D 60%, P = 0.02). These findings emphasize the need for caution in interpreting results, and the importance of working towards a standard definition of symptom palliation. The current lack of specified criteria makes analysis and interpretation of trial results difficult, and comparison across trials impossible. A standard definition of palliation for use in the analysis of clinical trials data is proposed, which takes into account aspects of onset, duration and degree of palliation, and symptom improvement, control and prevention.  (+info)

Patterns of care and survival for adolescents and young adults with acute leukaemia--a population-based study. (2/13843)

We report a population-based study of patterns of care and survival for people with acute leukaemia diagnosed at age 15-29 years during 1984-94 in regions of England and Wales covered by specialist leukaemia registries. There were 879 patients: 417 with acute lymphoblastic leukaemia (ALL) and 462 with acute myeloid leukaemia (AML). For ALL, actuarial survival rates were 43% at 5 years after diagnosis and 37% at 10 years. Survival improved significantly between 1984-88 and 1989-94 for those aged 15-19 at diagnosis. Patients entered in national clinical trials and those not entered had similar survival rates. Survival rates were similar at teaching and non-teaching hospitals and at hospitals treating different numbers of study patients per year. For AML, survival rates were 42% at 5 years after diagnosis and 39% at 10 years. Survival improved significantly between 1984-88 and 1989-94. Patients entered in the Medical Research Council AML10 trial had a higher survival rate than those who were in the earlier AML9 trial. Survival did not vary with category of hospital. We conclude that survival has improved for adolescents and young adults with acute leukaemia but that there is at present no evidence that centralized treatment results in a survival benefit for patients in this age group.  (+info)

U.S. Food and Drug Administration approval of AmBisome (liposomal amphotericin B) for treatment of visceral leishmaniasis. (3/13843)

In August 1997, AmBisome (liposomal amphotericin B, Nexstar, San Dimas, CA) was the first drug approved for the treatment of visceral leishmaniasis by the U.S. Food and Drug Administration. The growing recognition of emerging and reemerging infections warrants that safe and effective agents to treat such infections be readily available in the United States. The following discussion of the data submitted in support of the New Drug Application for AmBisome for the treatment of visceral leishmaniasis shows the breadth of data from clinical trials that can be appropriate to support approval for drugs to treat tropical diseases.  (+info)

Issues in the treatment of active tuberculosis in human immunodeficiency virus-infected patients. (4/13843)

Most HIV-infected patients with tuberculosis can be treated satisfactorily with standard regimens with expectations of good results. Treatment of tuberculosis in these patients has been complicated by the introduction of HAART, which relies on drugs that interfere with the most potent class of antituberculous medications. Rifampin-free regimens or regimens that employ rifabutin may be acceptable strategies for patients who are receiving protease inhibitors, although these regimens have not been rigorously evaluated in patients with AIDS. At present, there is good reason to believe that a 6-month course of a rifabutin-containing regimen or a 9-12-month course of a regimen of streptomycin, isoniazid, and pyrazinamide should be adequate therapy for most patients with drug-susceptible disease. As the treatment of HIV infection with antiretroviral agents evolves, the treatment of tuberculosis in patients with AIDS is likely to evolve as well. This will require careful coordination of antituberculosis and antiretroviral therapies.  (+info)

Contralateral fracture of the proximal femur. Implications for planning trials. (5/13843)

In three consecutive years 462 patients over the age of 60 years presented at Waikato Hospital, Hamilton, New Zealand, with a fracture of the proximal femur. Within two years, 11 (2.4%) returned with a fracture of the contralateral femur. If the effectiveness of any form of treatment aiming at reducing the incidence of contralateral fracture were subjected to a trial, a sample size of 5000, randomly distributed equally between treatment and placebo groups, would be needed for the trial to have a power of 80% to detect a reduction.  (+info)

Advances in therapy of multiple myeloma: lessons from acute leukemia. (6/13843)

This paper traces the lack of progress, until recently, in the treatment of multiple myeloma (MM) to having ignored the principles that led to cure in acute leukemia more than 2 decades ago. Only in the mid-1980s did investigation begin to consider complete remission (CR) a research objective, representing a necessary first step toward cure. The experience with autologous and allogeneic stem cell-supported high-dose therapy is reviewed, demonstrating, in both historically controlled and randomized studies, the validity of the dose-response concept in MM in terms of increased CR rates as well as extended event-free (EFS) and overall survival (OS). Avoidance of hematopoietic stem cell-damaging agents, especially melphalan, nitrosoureas, and ionizing radiation to marrow-containing sites, assures the ability of peripheral stem cell collection of high quality and quantity, providing rapid engraftment so that mortality is well under 5% following high-dose melphalan (200 mg/m2). This treatment can be applied safely to patients even >70 years of age and in the presence of renal failure. Tandem autotransplants after multiregimen induction have yielded CR rates in the 40% range with median durations of EFS and OS of 43 and 62 months, respectively. Certain chromosomal abnormalities (11 and 13; and translocations) represent the dominant adverse prognosticator for EFS and OS, confirmed in over 500 patients including those with prior therapy. Allogeneic transplants, possible in less than 10% of MM patients, are associated with a 50% mortality during the first year and, unfortunately, late relapses; thus, this approach should be reserved for patients with high-risk disease early in their management. A risk-based treatment algorithm that matches a patient's disease risk with the risk of intervention is presently used, followed by bisphosphonate therapy, not only to delay the onset of MM-related bone disease but also to induce tumor cell apoptosis, indirectly or directly, by down-regulation of cytokines with antiapoptotic activities. Although many patients relapse, this author subscribes to his mentor's motto: "Be Prepared for Success!".  (+info)

Drug development in solid tumors: personal perspective of Dr. Emil J Freireich's contributions. (7/13843)

The development of chemotherapy for patients with the major cancers progressed from the initial success attained in the treatment of acute leukemias and choriocarcinoma. Many of the principles of therapy were based on the concepts developed in the experimental laboratories and early clinical studies done at the NIH Clinical Center and other centers around the country. The purpose of this review is to describe some of the early advances in cancer therapy and show how many are based on the efforts of Dr. Emil J Freireich. Over his career, Dr. Freireich has published more than 500 papers and worked on more than 70 different drugs and combinations. The principles defined by Dr. Freireich, namely, the use of intermittent intensive chemotherapy to induce complete remissions (CRs), intensification of therapy in remission, and the use of unmaintained remissions to assess cure, have been important in developing curative chemotherapy programs in patients with acute leukemias. These same principles were applied to combination therapy of Hodgkin's disease as the nitrogen mustard, vincristine, procarbazine, and prednisone combination was developed. This led to the high CR and cure rate for this disease. The treatment of metastatic breast cancer does not produce a high proportion of CRs, and cures of metastatic disease are unlikely with chemotherapy alone. But adjuvant chemotherapy after surgery has resulted in a significant reduction in cancer mortality. Many challenges remain in increasing the cure rate for the major solid tumors. New avenues of controlling cell growth and metastases need to be explored. One approach that is exploitable is the use of drugs or nutrients to prevent cancer. Laboratory approaches are now becoming a clinical reality.  (+info)

Can we cure indolent lymphomas? (8/13843)

The current consensus is that indolent lymphomas are incurable disorders. There are some indications that these malignancies are potentially curable. Indeed, not all indolent lymphomas are currently incurable. For example, patients with Ann Arbor stage I-II indolent lymphomas can experience long-term disease-free survival and probable cure. Also, from the available literature data, it seems that the achievement of a molecular complete remission is a desirable objective. Patients who achieve a persistently negative PCR state seldom relapse, whereas the opposite is true for persistently positive cases. In view of its excellent correlation with disease-free survival when examined serially in multiple blood or marrow samples, the PCR technique has the potential of providing a tumor marker that can be used as an early end point for clinical trials. By serving as an early surrogate end point, PCR could play an important role in expediting the development of new treatment strategies. Whether IFN is capable of increasing the molecular complete remission rate as measured by PCR is not known. However, it is clear that from the clinical standpoint, IFN has been able to increase 2-fold the length of remission in patients with advanced indolent lymphomas. In at least two studies, this has been associated with prolongation of survival. More intensive regimens such as alternating triple therapy, when used in combination with IFN, seem to have improved the quality of remissions as judged by the PCR assay. Finally, the site where the bcl-2 breakpoint occurs seems to have clinical significance. Those follicular lymphomas with germ-line bcl-2, in our experience, have behaved more aggressively than the others, and their failure-free survival seems different from the usual indolent lymphomas and more closely resembles the large cell lymphomas. Although the biological significance of this observation is not yet understood, this group might actually constitute a prognostically different subset with a more aggressive and perhaps more curable lymphoma. Whether the plateau observed in their failure-free survival curve will be maintained with more follow-up and whether they might be a curable subset remain to be determined.  (+info)

Healthcare Clinical Trial Management Systems - Global Market Demand, Growth, Opportunities, Manufacturers, Analysis of Top Key Players and Forecast to 2025". PUNE, MAHARASHTRA, INDIA, February 13, 2018 /EINPresswire.com/ - Healthcare Clinical Trial Management Systems Market 2018 Description: In this report, the global Healthcare Clinical Trial Management Systems market is valued at USD XX million in 2017 and is expected to reach USD XX million by the end of 2025, growing at a CAGR of XX% between 2017 and 2025.. Geographically, this report is segmented into several key Regions, with production, consumption, revenue (million USD), market share and growth rate of Healthcare Clinical Trial Management Systems in these regions, from 2013 to 2025 (forecast), covering ...
are research studies that test new ways to prevent detect treat or manage cancer or other diseases Clinical trials provide information about the safety and effectiveness of new approaches to see if they should become widely available Most of the standard cancer treatments used today were first shown to be effective through clinical trials Participation in a clinical trial may be an option for a person with cancer or someone at risk for developing cancer People decide for themselves whether or not they want to participate in a clinical trial The importance of clinical trials Clinical trials add to the progress that is being made against cancer They answer important scientific questions and lead to future research Many people with cancer are now living longer because of progress made through clinical trials Findings from past clinical trials have led to new and more effective drugs for specific types of cancer drugs with fewer side effects less invasive methods of surgery Types and phases There ...
Despite the best intentions of the European Medicines Agency injunctions issued against it in two court cases have spilled over to chill other requests for clinical trial information. There are at least 100 pending requests seeking trial results. Over the past 24 hours researchers have received letters telling them the EMA cannot release documents it holds from clinical trials of medicines currently used in Europe.. The letter from the EMA states that "in the course of on-going legal proceedings before the General Court of the European Union, the Agency has been ordered to suspend the implementation of certain decisions granting access to documents submitted by marketing authorisation holders of medicinal products.". The legal proceedings are the cases brought by two pharmaceutical companies, InterMune and AbbVie, who challenged the Agencys decisions to grant access to clinical study reports from clinical trials of drugs from each of these companies. On 25th April the President of the European ...
Press Release issued Jul 13, 2015: GlobalDatas clinical trial report, Cholera Global Clinical Trials Review, H1, 2015 provides an overview of Cholera clinical trials scenario. This report provides top line data relating to the clinical trials on Cholera. Report includes an overview of trial numbers and their average enrollment in top countries conducted across the globe. The report offers coverage of disease clinical trials by region, country (G7 & E7), phase, trial status, end points status and sponsor type. Report also provides prominent drugs for in-progress trials (based on number of ongoing trials). Global Data Clinical Trial Reports are generated using Global Datas proprietary database - Pharma eTrack Clinical trials database. Clinical trials are collated from 80+ different clinical trial registries, conferences, journals, news etc across the globe. Clinical trials database undergoes periodic update by dynamic process.
Patients and Methods We assessed clinical trial participation patterns according to important SES (income, education) and demographic factors in a large sample of patients surveyed via an Internet-based treatment decision tool. Logistic regression, conditioning on type of cancer, was used. Attitudes toward clinical trials were assessed using prespecified items about treatment, treatment tolerability, convenience, and cost. Read more. ...
Reporting Clinical Trial Results To Inform Providers, Payers, And Consumers Conventional analyses of clinical trials can underestimate potential risks and benefits to patients. by Rodney A. Hayward, David
Glycotope Receives Regulatory Approval For Glycoexpress(TM) Technology And Initiates First Clinical Trial With Lead Antibody GT-MAB 2.5-GEX - read this article along with other careers information, tips and advice on BioSpace
The Early Phase Clinical Trials Team (EPCTT) was established in 2008 to focus on early phase trials and experimental medicine for priority cancers for the Anglia region.
Copenhagen, Denmark New clinical trial data just published in Pediatric Diabetes show that Levemir (insulin detemir), Novo Nordisk s basal insulin analogue, is
The Experimental Tuberculosis Unit, together with the Pharmacology Dept of the Hospital Universitari Germans Trias i Pujol and the Clinical Trials Unit of the IGTP, present today the results of NYADATREG (ClinicalTrials.gov Identifier: NCT02076139) , the first clinical trial conducted with the food supplement Nyaditum resae®. Designed and patented at the Experimental tuberculosis Unit and…
is this a new one? Medical College selected as one of 7 sites for first clinical trial to use human embryonic stem cells By Mark Johnson of the Journal Sentinel July 11, 2011 5:26 p.m. |(1) Comments The Medical College of Wisconsin is to be one of seven sites for the first trial to use human embryonic stem cells in the treatment of spinal cord injuries.
In an international clinical trial a new drug that selectively blocks...Patients who took the experimental drug a co-stimulatory blocker call...In the August 25 issue of The New England Journal of Medicine researc...The results mark an important step toward proving the value of a new t... This is the first clinical trial of a treatment for transplant recipi...,New,type,of,rejection,blocker,protects,kidneys,after,transplant,biological,biology news articles,biology news today,latest biology news,current biology news,biology newsletters
In an article reporting the 18-month results of the ITNs RAVE clinical trial, published August 1st in the New England Journal of Medicine, the ITN is providing unfettered access to the underlying clinical data and analysis code via the new clinical trials research portal, ITN TrialShare. TrialShare is a significant advance in data sharing and transparency, allowing for collaborative hypothesis generation and specimen sharing between the ITN and the broader scientific community. TrialShare gives researchers the ability to access raw study data, confirm published conclusions and interactively perform their own exploratory analyses using this data.. "Direct access to raw clinical trial data will change the landscape of collaborative research" said Peter C. Grayson, MD, MSc of Boston University Medical Center, a collaborator with the ITN. "TrialShare creates unfettered opportunities to explore and understand the intricacies of clinical trial data. Better understanding of primary data leads to ...
Penn Medicine will conduct the Northeasts first clinical trial of uterine transplants, to provide women with Uterine Factor Infertility (UFI) -- an irreversible form of female infertility that affects as many as 5 percent of women worldwide and 50,000 women in the United States -- with a new path to parenthood.
Clinical Courses - This is designed to give you an overview of the clinical Drug Trials trainings from many other topics as they apply to your position in the organization.
Welcome to the eCancerTrials.com National Cancer Clinical Trials Database. When you or a loved one are diagnosed with cancer, knowing every treatment option available is your first step in receiving the most complete care. Your treatment plan may include choosing to participate in a cancer clinical trial. Clinical trials in cancer are research studies designed to evaluate new cancer treatment, management, and prevention options. Clinical trials conducted with cancer patients evaluate the safety and effectiveness of new or modified cancer treatment strategies. New anticancer drugs, unique approaches to surgery and radiation therapy are used as well as various combinations of cancer treatments.. Many medical professionals encourage those diagnosed with cancer to at least consider participating in a clinical trial in addition to other treatment options. Furthermore, many treatment options for cancer patients are only available through clinical trials, making participation in a trial the only way to ...
HPV is a major cause of changes in the cervix. These changes are much more common in women with HIV and could lead to cancer of the cervix. The AIDS ...
I just finished my public comments to the EU about the Summary of Clinical Trial Results for Laypersons. You can too if you hurry (public comments end on 8/31/16). Here are the instructions. I would appreciate your support on some of the key points listed below. A bit of background The European Medical Agency (EMA)…
Lipocine Announces LPCN 1144 Clinical Trial Results Selected for Late-Breaker Presentation at The Liver Meeting® 2018 - read this article along with other careers information, tips and advice on BioSpace
Phase I (one) medical and clinical trial recruitment. Volunteer to join trials or advertise a clinical trial or medical study on MedTrials.
Modernization of eligibility criteria could have beneficial effects on improving clinical trial enrollment, said speakers representing the first panel at the FOCR meeting. "Its been a struggle to put patients on trials," said Edward S. Kim, MD, a co-author of the first white paper, Chair of Solid Tumor Oncology and Investigational Therapeutics and holder of the Donald S. Kim Distinguished Chair for Cancer Research at the Levine Cancer Institute, Carolinas HealthCare System in Charlotte, N.C.. Authors of the first white paper concluded there is a need for a re-evaluation of clinical trial eligibility, including the exclusion of patients with prior cancers. They noted that data have shown "prior malignancies did not impact survival outcomes in patients with stage IV lung cancer or locally advanced lung cancer, suggesting clinical trial outcomes would not be adversely impacted by inclusion of patients with a history of prior cancer." The first panel concluded patients should not be routinely ...
New Clinical Trials in Prostate Cancer. William K. Oh, M.D. Clinical Director, Lank Center for Genitourinary Oncology Dana-Farber Cancer Institute Associate Professor, Harvard Medical School. U.S. Cancer Statistics: Prostate Cancer 2007. Leading cause of cancer in men (218,890 cases, 29%) Slideshow 63801 by RexAlvis
This resource center is for patients and families coping with cancer and interested in learning about clinical trials for the disease. You can find information here on how clinical trials are structured and managed, how to find and evaluate clinical trials, how eligibility to participate is determined, the ethics of conducting clinical trials, special types of clinical trials, and financial issues related to clinical trials.
Selection of target sample size is a critical factor in the design of any randomized trial. Although calculations are straightforward, the underlying assumptions are frequently based on incomplete data. Relatively small errors in the assumptions can design a trial that is either substantially under- or overpowered.. One of the more rapidly evolving clinical trial methodological areas is that of adaptive clinical trials, where the study design is adjusted based on data collected as part of the initial conduct of the trial. Methods for adaptive trials are sometimes confused with the much more mature methodological area of group sequential trials.7-9 Shih eloquently relates that group sequential trial methodology has the goal of "saving lives or saving resources" whereas the adaptive clinical trial approach has the goal of "saving the study."10. There are 2 approaches of adaptive trial methodology. The first examines estimates of parameters that were assumed during the design phase of the project ...
A clinical trial is a research study on human volunteers designed to answer specific health questions. The purpose of a clinical trial is to find out whether a medicine or treatment regimen is safe and effective against a specific condition or disease.. Clinical trials compare the effectiveness of the study medicine or treatment against standard, accepted treatment or a placebo. (A placebo is an inactive substance used to compare results with an active substance). Early (phase I) trials establish the safety, toxicity, and safe dosing ranges of a new treatment.. A clinical trial may be sponsored by a government agency, such as the National Institutes of Health, or a pharmaceutical or biotechnology company. All clinical trials are guided by government regulations. These rules make sure that participants are not likely to be harmed and that they fully understand the risks and benefits of participating. ...
RATIONALE: Studying Pap smears in the laboratory from women with atypical glandular cells of unspecified significance may help doctors learn more about changes that may occur in DNA and identify biomarkers related to cancer.

PURPOSE: This research study is looking at Pap smears from women enrolled on clinical trial GOG-171.
Read about Qu Biologics Cleared to Proceed with Crohns Disease Clinical Trial, according to a review from the Data Safety Monitoring Committee.
All patients complete a baseline assessment to assess demographics, personal characteristics, preparedness, and barriers to clinical trials. All patients also undergo a post-intervention assessment and complete a survey to measure preparedness for consideration of clinical trials, and impact of the intervention on clinical trials barriers. A brief patient post-consultation assessment is completed by patients within two weeks of the physician consultation to determine whether clinical trials were discussed, patient satisfaction with discussion about clinical trials, treatment options, treatment selection, decisional conflict, and satisfaction with treatment decision. Quality of informed consent is also assessed for patients participating in a clinical trial and completing the consent process during their initial physician consultation. Each patients physician completes a brief Physician Post-Consultation Assessment to define cancer stage, treatment goal, and to determine whether clinical trials ...
We have an exciting opportunity for a Portfolio Lead to join the Oncology Clinical Trials Office (OCTO), working in a team of trial management professionals running a varied portfolio of clinical trials and related sub-studies.You will be responsible for working with Chief Investigators and statisticians to develop new research proposals for funding applications, developing new clinical trial protocols, coordinating application submissions and ensuring that all appropriate documentation, reviews and approvals are in place.You will be responsible for the line management and oversight of proj ...
Taking part in a clinical trial can be a good choice but it is often hard to find a clinical trial that is right for you. Many patient organisations and websites maintain lists of clinical trials. The following table lists some of the clinical trials available worldwide. Please note: this is not an exhaustive list, so please check with your local patient organisation. Other trials may be available in your country. If you are aware of an open trial that should be listed here, please send us the trial information to: Questo indirizzo email è protetto dagli spambots. È necessario abilitare JavaScript per vederlo.. ...
The Oncology Clinical Trials Program enables patients to access a wide spectrum of newly advanced treatments including immunotherapeutic drugs and targeted therapies for a range of solid and haematological malignancies.. Established in 2003 and led by Associate Professor Gary Richardson OAM, the Department aims to provide compassionate, state-of-the-art care for cancer patients and continued advancements in the prevention, diagnosis, treatment and cure of cancer via a combination of research, education and clinical practice.. How can you participiate in a clinical trial at Cabrini. The Szalmuk Family Department of Medical Oncology currently has more than 100 active clinical trials covering many different cancer streams. If you are interested in participating in a trial, please speak to your treating oncologist first. Your oncologist will provide you with general information on clinical trials and also discuss programs that may be relevant to you.. All patients with private health insurance can ...
Ask your neurologist or movement disorders specialist about participation in clinical trials. Specifical clinical trials vary by region and center. If you are receiving treatment at a specialized movement disorders center, there may be already ongoing trials at your center in which you can participate. The website www.clinicaltrials.gov also has updated information in all current clinical trials performed in the United States.
Disclaimer: Trials posted on this search portal are not endorsed by WHO, but are provided as a service to our users. In no event shall the World Health Organization be liable for any damages arising from the use of the information linked to in this section. None of the information obtained through use of the search portal should in any way be used in clinical care without consulting a physician or licensed health professional. WHO is not responsible for the accuracy, completeness and/or use made of the content displayed for any trial record. ...
Background: Cancer is currently the second leading cause of death in the USA, however many gains are being made in cancer therapeutics due in large part to patient participation in clinical trials. It is estimated that 20% of patients nationwide are eligible for a clinical trial, but only 3% are actually enrolled. At the University of Chicago, almost 50% of new patients are eligible for a cancer clinical trial, but only 15% are enrolled. Furthermore, only half of eligible patients are offered enrollment. African-Americans have worse outcomes across the cancer care continuum compared to Caucasians; however these outcomes can be ameliorated when patients receive standardized care according to a clinical trial. African-Americans are underrepresented amongst cancer clinical trial participants, despite evidence from our institution that African-Americans were more than twice as likely as Caucasians to enroll in a cancer clinical trial when offered. We hypothesize that a provider-directed intervention ...
Background Pharmaceutical trials are mainly initiated by sponsors and investigators in the United States, Western Europe and Japan. However, more and more patients are enrolled in Central and Eastern Europe, Latin America and Asia. The involvement of patients in new geographical settings raises questions about scientific and ethical integrity, especially when experience with those settings is lacking at the level of trial management. We therefore studied to what extent the geographical shift in patient enrolment is anticipated in the composition of trial management teams using the author nationalities on the primary outcome publication as an indicator of leadership. Methods and Findings We conducted a cohort-study among 1,445 registered trials in www.clinicaltrials.gov that could be matched with a primary outcome publication using clinical trial registry numbers listed in publications. The name of the sponsor and the enrolment countries were extracted from all registrations. The author-addresses of
Our New Medical Therapies(TM) Trial Results database provides a snapshot of results from completed and ongoing clinical trials, based on published materials from medical conferences, journals and CenterWatch reports. View Crohns Disease clinical trial results here.
Quality Clinical Trial Monitoring in Nigeria: Impact of Regulatory Oversight and Resource Capacity. Barriers to Recruitment in Clinical Trials amongst HIV Positive Patients on Antiretroviral Therapy in Mombasa, Kenya, a Resource Limited Setting. The use of pharmacogenetic studies of efficacy and safety during key phases of the drug development process. The spillover effects of a phase III clinical trial on non-study participant children aged under 5 years in Western Kenya. The reporting of harms in randomized controlled trials in patients with hypertension. Description of current clinical research advertisements and exploring the acceptance of the Centre for Information & Study on Clinical Research Participations (CISCRP) medical heroes advertisement campaign as a model for increasing clinical trial recruitment in Toronto.. An exploratory study to identify challenges to full Good Clinical Practice (GCP) compliance in sub-Saharan Africa. Estimating clinical and non-clinical resources via ...
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Guthrie Health is dedicated to providing high-quality and accessible health care that meets the needs of the entire family. Guthrie Health is a not-for-profit health care organization that includes primary care and specialty physicians, serving the Twin Tiers Region of Northern Pennsylvania and Southern New York including cities of Corning, Elmira, Horseheads, Big Flats, Vestal, Ithaca, Troy, Sayre and Wellsboro. It is the parent corporation of Robert Packer Hospital, Corning Hospital and Troy Community Hospital; as well as a multi-specialty practice with services such as Orthopedics, Cardiology, Cancer, Pediatrics and Family and Internal Medicine.
Guthrie Health is dedicated to providing high-quality and accessible health care that meets the needs of the entire family. Guthrie Health is a not-for-profit health care organization that includes primary care and specialty physicians, serving the Twin Tiers Region of Northern Pennsylvania and Southern New York including cities of Corning, Elmira, Horseheads, Big Flats, Vestal, Ithaca, Troy, Sayre and Wellsboro. It is the parent corporation of Robert Packer Hospital, Corning Hospital and Troy Community Hospital; as well as a multi-specialty practice with services such as Orthopedics, Cardiology, Cancer, Pediatrics and Family and Internal Medicine.
CLINICAL TRIAL PLANNING GRANT Release Date: October 1, 2001 RFA: RFA-AR-02-001 National Institute of Arthritis and Musculoskeletal and Skin Diseases (http://www.nih.gov/niams/) Letter of Intent Receipt Date: February 22, 2002 Application Receipt Date: March 22, 2002 THIS RFA USES "MODULAR GRANT" AND "JUST-IN-TIME" CONCEPTS. MODULAR INSTRUCTIONS MUST BE USED FOR RESEARCH GRANT APPLICATIONS REQUESTING LESS THAN $250,000 PER YEAR IN ALL YEARS. MODULAR BUDGET INSTRUCTIONS ARE PROVIDED IN SECTION C OF THE PHS 398 (REVISION 5/2001) AVAILABLE AT https://grants.nih.gov/grants/funding/phs398/phs398.html. PURPOSE The purpose of the NIAMS Clinical Trial Planning Grant is to provide support for the organization of activities critical for the successful implementation of clinical trials in areas within the NIAMS mission. The planning grant is intended to (a) allow for early peer review of the rationale and design for high risk, complex, or large-scale clinical trials; (b) provide support for the development ...
The most efficient and ethical manner for a patient to access a medicine prior to it being approved by regulatory authorities is to enroll in a clinical trial. Well-designed and conducted clinical trials are essential in bringing new treatments to patients. People who choose to participate in clinical trials play a critical role in developing new medicines where the ultimate goal is the securing of regulatory approval enabling the medicine to be available to as many patients as possible.. The sponsor of a clinical trial has an ethical responsibility to protect the rights and safety of clinical trial participants and ensure the integrity of the trials conducted. Individuals participating in Ideras clinical trials are provided with the treatment being tested. The purpose of these trials is to discover whether the treatment is safe and effective. Until the regulatory authority has made this decision on the safety and efficacy, the treatment remains experimental and is not generally available to ...
Dr. Steeg: I completely agree. For breast cancer, we know enough about the molecular biology of progression of breast cancer so we can predict groups of patients who are at very high risk for metastatic progression within what I would call a few years-2 to 3 years. One of those groups would be those patients who come in with very large primary tumors, that just grew too fast and they get up-front chemotherapy, they dont go straight to surgery-this is called neoadjuvant chemotherapy. So they get up-front chemotherapy to shrink that tumor down. There are cases where that up-front chemotherapy shrinks that tumor away to nothing and these patients are associated with very good outcomes. But unfortunately, there are a lot of cases where that up-front chemotherapy does not significantly shrink that tumor and the patient goes to surgery. And those patients are at very high risk in a couple of years for metastatic disease. Now the FDA just issued guidance on doing clinical trials in that neoadjuvant ...
Because the advantages of clinical trials registries are so great and because several forces now demand their creation, the challenge is to develop systems that will be accessible to a range of persons and serve a range of interrelated purposes (39). Given these broad goals, several authors have suggested the types of elements that should be included in a clinical trials registry (7, 22, 25, 27). All agree on the high-level categories of information that should be present in a full clinical trials protocol (40), although there are differences in the emphasis placed on those categories. General and administrative information includes the trial name or title, a registration number, the funding source, the site at which the trial is being conducted, the name and affiliation of the investigators, the study start and completion dates, and the recruiting status of the trial. The purpose and objectives of the trial include the disease or condition being treated or evaluated, the treatments or ...
AstraZeneca has filed a Clinical Trial Application (CTA) with the Paul Ehrlich Institute and the German Federal Ministry of Health to initiate a Phase I clinical trial of AZD8601.
This program is a unique and innovative funding opportunity designed to help outstanding Canadian researchers accelerate the development of safer and more effective treatments for neurodegenerative diseases of aging. Projects should have demonstrated excellent preliminary data and be focused on generating results to support the next stage of clinical trials.. ...
SAN DIEGO, May 28, 2019 /PRNewswire/ - Ansun Biopharma, Inc., today announced that the first patient has been enrolled in its Phase 3 clinical trial evaluating the efficacy and safety of DAS181 for the treatment of hospitalized, immunocompromised patients with lower respiratory tract parainfluenza virus infection. The Phase 3 clinical trial (STOP PIV) is being conducted in multiple study centers throughout the U.S., Europe and Asia. "Parainfluenza infection in normal, healthy patients is not a life-threatening disease. But in hospitalized, immunocompromised patients who are trying to recover from cancer or an organ transplant, for example, it can cause respiratory complications that may be deadly or cause permanent damage to the lungs, and is an area of unmet medical need," stated Dr. Stanley Lewis, Ansuns Chief Medical Officer. There are no approved drugs to treat parainfluenza infection, making DAS181 a potentially first-in-class therapeutic to treat these most vulnerable patients. DAS181 is ...
... are behavioural or biomedical research studies that are performed to answer questions about biomedical or behavioural interventions such as new vaccines, treatments, drugs or devices. Trials can vary in size from quite small to very large. Clinical trials are funded by a variety of organizations, including the government or a biotechnology, pharmaceutical or medical device company.. Clinical trials are conducted on human subjects, only after approval from the local ethics committee and health authority. Clinical trials often involve healthy subjects who have no pre-existing medical conditions and who receive financial incentives. They may also pertain to patients with specific health conditions who want to receive otherwise unavailable treatments. In order to be ethical, researchers must obtain fully informed consent of participants.¹. One of the most famous clinical trials was performed by James Lind in 1747, where he demonstrated that citrus fruits cure scurvy. Lind compared ...
At the VISIONS 2014 session titled "Clinical Trials: Am I Ready?" Christine Kay, M.D., Shannon Boye, Ph.D., and Jacque Duncan, M.D., reviewed the factors that help determine whether someone will qualify for a clinical trial. A persons genetic profile, retinal condition, visual ability, age and residence are all key characteristics that clinical researchers consider when selecting participants. The investigators also noted that finding an adequate number of participants for the studies is often challenging.. But Dr. Duncan, the new chairman of the Foundations Scientific Advisory Board, cautioned that participation in a human study is not a fast track to treatment. "If we knew the therapy was going to be safe and effective, we wouldnt be doing the trial," she said during her closing remarks.. However, Dr. Duncan explained, patient participation is essential to gaining regulatory approval for therapies so everyone can get access to them. "People who participate in clinical trials are absolutely ...
... that are both pharmaceutical sponsored and investigator driven provide an opportunity for participation..
Our New Medical Therapies(TM) Trial Results database provides a snapshot of results from completed and ongoing clinical trials, based on published materials from medical conferences, journals and CenterWatch reports. View Endometrial Cancer clinical trial results here.
Pfizer is currently recruiting for the NCT02679755 Breast Cancer Cancer trial. Review trial description, criteria and location information here.
On Tuesday, April 11, 2017, Stop Childrens Cancer leaders and board members, along with Dr. Scott Rivkees, Dr. Parker Gibbs, Ed Jimenez and others from the UF Department of Pediatrics and UF Health, met for a sponsors breakfast and tour of UF Health Shands Childrens Hospital. During the event, UF Health CEO Ed Jimenez and Stop Childrens Cancer President Chris Conner signed a $1 million pledge, which will support pediatric clinical trials, including a novel clinical trial focused on improving the cure rates for children with osteosarcoma and Ewings sarcoma. UF Health is honored to receive support and funding from Stop Childrens Cancer so that we can one day cure childrens cancers.. ...
Read about how antibiotics developer Cempra Inc. has released positive interim results from a Phase II clinical trial for their drug, solithromycin, in the treatment of non-alcoholic steatohepatitis (NASH)
Seattle Cancer Care Alliance (SCCA) was formed, in part, to bring promising new treatments to patients faster. For sarcoma patients, this means more treatment options at SCCA than you might find elsewhere, including the chance to participate in one of many ongoing clinical trials conducted at SCCA and its partner organizations, Fred Hutch and UW Medicine.. ...
I want to see the results of the clinical trials using the triple treatment and Incivek. Many people have talked about reaching success in taking it only 8 weeks during trials - also many have mention...
Panelists:Adam M. Brufsky, MD, PhD, University of Pittsburgh; Sara Hurvitz, MD, UCLA; Joyce A. O Shaughnessy, MD, US Oncology; Edith A. Perez, MD, Mayo Clinic; Hope S. Rugo, MD, UCSF; Andrew D. Seidman...
... at top hospitals in the Mid-Atlantic (Maryland, Virginia, and Washington, D.C.) that are currently recruiting patients.
Early Phase 1 Trials (formerly listed as Phase 0): Exploratory trials conducted before traditional phase 1 trials to investigate how or whether a drug affects the body. They involve very limited human exposure to the drug and have no therapeutic or diagnostic goals (for example, screening studies, microdose studies).. Phase 1 Trials: Trials that focus on the safety of a drug. They are usually conducted with healthy volunteers, and the goal is to determine the drugs most frequent and serious adverse events and, often, how the drug is broken down and excreted by the body. These trials usually involve a small number of participants.. Phase 2 Trials: Trials that gather preliminary data on whether a drug works in people who have a certain condition/disease (that is, the drugs effectiveness). For example, participants receiving the drug may be compared to similar participants receiving a different treatment, usually an inactive substance (called a placebo) or a different drug. Safety continues to be ...
... at top hospitals in the Mid-Atlantic (Maryland, Virginia, and Washington, D.C.) that are currently recruiting patients.
Clinical Research, Clinical Study, Clinical Trial, and Clinical Protocol all concern the same topic. These terms are often used interchangeably to talk about scientific studies that use people to understand if new drugs, treatments and devices are safe and effective. Clinical studies cannot happen until basic research in a laboratory determines the new treatment, drug or device is successful and safe. Once basic research indicates scientific promise, the FDA must approve continuing the research and beginning to test in people. Carefully controlled and well-designed clinical trials are performed by highly trained medical professionals to understand how this new treatment will work in people. The clinical trial is trying to duplicate the promising lab results in people.. Clinical Trials are conducted in four phases that occur in sequential order. Each phase tends to have a different purpose and helps answer different questions. Each phase is considered a separate trial. After completion of each ...
To meet the financial challenge, the Institute has just launched a new website: www.ZapCancer.org which explains the protocol, provides vital answers for cancer patients, collects tax-deductible donations to fund the clinical trial, and contains a video presentation produced by N.Y. Times best-selling author, Steve Alten, whose father died from melanoma two weeks before he was to receive the protocol. Says Alten, "Cancer is a horrible disease that affects all of us. And yet, if a million people simply donated $10, the Institute could complete the first phases of this vitally important investigation, a necessary step to one day treating patients worldwide. For the simple cost of a movie ticket or paperback book, we could help fund a potential cure for solid tumor cancers. I pray that everyone will take a look at the ZapCancer.org website, make a small donation, and spread the link around ...
We are doing this study to find out if the study drug atezolizumab given with the usual chemotherapy is better, the same, or worse... | View the details of this clinical trial.
Uveitis ongoing clinical trials report provides comprehensive analysis and trends in global Uveitis disease clinical trials. The research work analyzes the ongoing ...
Footnotes] 1) Nasal delivery technology platform is SNBLs novel technology, covered by international patents, which significantly enhance the absorption of powder nasal drugs from the nasal mucosa. The technology has been shown in several clinical trials to be safe and effective under the clinically tested conditions. Is a fundamental technology that is versatile can be applied to various drugs. , we have conducted several clinical trials to date, this technology, safety and efficacy in into the conditions of the clinical trials. (http://www.snbl-nds.co.jp/en/). 2) Translational Research Business is SNBLs business unit that takes a medical technology from basic research to a clinical application. SNBL utilizes its own preclinical and clinical facilities to incubate early technologies by value-adding research or conducting development and licensing the technology to biopharmaceutical companies. 3) Drug reprofiling is analyzing and screening using innovative methods for existing drug products ...
Clinical trials provide information about the safety and effectiveness of new approaches to see if they should become widely available. Most of the standard cancer treatments used today were first shown to be effective through clinical trials.. There are many reasons why someone may choose to take part in a clinical trial.. ...
Clinical trials project management has changed over the years. Over the past decade, one method that has been used more and more is referred to as comparator sourcing of drugs, This practice has become more and more important to the process of developing new drugs, especially for problems that do not currently have great treatments available. When one treatment is undeniably better than the placebo, the other treatment for the condition is considered to be the go to treatment. In comparator sourcing, the new treatment is compares to the this standard.. There are ways to design your clinical trials to make the most of comparator sourcing techniques and methods. Here are some tips to getting the most from your clinical trials using comparator sourcing:. Develop your comparator sourcing long before the clinical trials begin. If you really want to get the most from the clinical trial process and know a big part of that is going to be achieved through the use of comparator sourcing, you need to ...
Download free ebook: Clinical Trials Design in Operative and Non Operative Invasive Procedures. 2017 ; ISBN-10: 3319538764 ; 520 Pages ; EPUB . download ebook - Home,Science,Medicine, pdf
Medgenics, Inc. (NYSE MKT: MDGN and AIM: MEDU, MEDG) (the “Company”), the developer of a novel platform technology for the sustained production and delivery of therapeutic proteins in patients using their......MDGN
A course dedicated to educating the next generation of oncologists about the essentials of clinical trial design, implementation, and analysis, will b
A research team at The University of Nottingham is calling on people diagnosed with mild asthma to take part in a clinical trial to see whether a simple new breath test can improve the diagnosis and treatment of the condition.
Medical testing business preMD has launched a clinical trial with a global cosmetics company, focusing on its skin cholesterol test. Partnerships between medical companies specializing in predictive tests and personal care players are becoming increasingly common, as the opportunities for personalized cosmetics become apparent.
The clinical trial below was posted (on clinicaltrials.gov) in June, 2017. We offer treatment search services for the latest developments in treatment of
Pfizer is currently recruiting for the NCT00327691 Cardiovascular Disease, Cerebrovascular Accident, Coronary Heart Disease Cancer trial. Review trial description, criteria and location information here.
Going through trials? Youll learn why all Christians will have to go through a certain amount of trials and tribulations in this life with the Lord.
Hi there! Im new here and I was wondering if there are any upcoming clinical trials. Id like to get on the list for those! Thanks, Jennifer
SAN DIEGO, CA--(Marketwired - Dec 19, 2016) - CEOCFO Magazine, an independent investment publication that highlights important technologies and companies, today released an interview with Dr. Bassam Damaj, CEO of Innovus Pharmaceuticals, Inc. (OTCQB: INNV), a pharmaceutical company that is achieving major increases in revenue. In the interview, Dr. Damaj...
Clinical trials are studies that operate under a set purpose to answer a specific question regarding a certain disease, illness, or disorder. They have strict conditions under which they operate, along with a set purpose and a set time. Clinical trials can operate at the same time throughout a variety of locations across the country and even across the world.
Introduction This report is an update on my thinking on Cytokinetics. It should be read in conjunction with earlier reports, especially my initiation report of March 15, Cytokinetics: Critical Phase IIB Data is Upcoming in 2013 for Omecamtiv Mecarbil and Tirasemtiv (CYTK, $6.30). In that report, I first recommended
free ebooks cowboy life on the sidetrack being an extremely humorous sarcastic story of the trials tribulations endured by a party of stockmen making a shipment from the west to the east.html document available with no premium account to get it
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regarding SPR720 and the commencement of Speros planned Phase 2a clinical trial of SPR720; statements regarding managements assessment of the results of such preclinical studies and clinical trials; the timing of clinical data, including the availability of pharmacokinetic data from the lead-in cohort in the Phase 3 clinical trial of SPR994, final data from the Phase 1 clinical trial of SPR720 and top-line data from the Phase 1 clinical trial of SPR206; and Speros cash forecast and anticipated expenses, the sufficiency of its cash resources and the availability of additional non-dilutive funding from governmental agencies beyond any initially funded awards. In some cases, forward-looking statements can be identified by terms such as "may," "will," "should," "expect," "plan," "aim," "anticipate," "could," "intent," "target," "project," "contemplate," "believe," "estimate," "predict," "potential" or "continue" or the negative of these terms or other similar expressions. Actual results may ...
There has been considerable evolution in the evaluation of scientific evidence and in the development of evidence-based guidelines since the ADA first began publishing practice guidelines. Accordingly, we developed a classification system to grade the quality of scientific evidence supporting ADA recommendations for all new and revised ADA position statements.. Recommendations are assigned ratings of A, B, or C, depending on the quality of evidence (Table 1). Expert opinion (E) is a separate category for recommendations in which there is as yet no evidence from clinical trials, in which clinical trials may be impractical, or in which there is conflicting evidence. Recommendations with an "A" rating are based on large well-designed clinical trials or well-done meta-analyses. Generally, these recommendations have the best chance of improving outcomes when applied to the population to which they are appropriate. Recommendations with lower levels of evidence may be equally important but are not as ...
The AMA has now added its voice by calling for a specific set of reforms. Concerns long have been simmering over the need for more transparency in the clinical trial process, and the AMA Council on Scientific Affairs put together a compelling case. In a June report, it outlined the potential for publication bias in pharmaceutical research and how such biases threaten to distort the medical literature, thereby affecting the validity and findings of subsequent reviews and analyses and even decisions by government agencies and health plans.. Ultimately, a comprehensive clinical trial registry is viewed as a mechanism that would correct these shortcomings by putting a wealth of trial information in a central place.. Thats why delegates to the AMA Annual Meeting in Chicago last month urged the U.S. Dept. of Health and Human Services to establish such a registry for all clinical trials and require every trial to have a unique identifier.. The AMA is not alone in advancing this position. Its policy is ...
National Institutes of Health website helps people learn more about clinical trials, why they matter, and how to participate. Clinical trials are essential for identifying and understanding ways to prevent, diagnose, and treat disease. Research has shown that among the greatest challenges to recruitment of volunteers is the lack of general knowledge about what trials involve, where they are carried out, and who may participate. Visitors to the website will find information about: a) The basics of clinical trial participation b) First hand experiences from actual clinical trial volunteers c) Explanations from researchers d) Links on how to search for a trial or enroll in ResearchMatch.org ...
In 2004, The Ministerial Summit on Health Research in Mexico City stated that, Research results must be published, documented in internationally accessible registers and archives, and synthesized through systematic reviews. These actions can help to inform decisions about support for new research and to build public confidence in science [62]. The Summit called for action by All major stakeholders, facilitated by the WHO Secretariat, to establish a platform linking a network of international clinical trials registers to ensure a single point of access and the unambiguous identification of trials.. In 2008, the Global Ministerial Forum on Research For Health in Bamako agreed To develop, set, and enforce standards, regulations, and best practices for fair, accountable, and transparent research processes and the registration and results reporting of clinical trials, and open and equitable access to research data, tools, and information [62, 63].. In 2010, the World Bank announced that it ...
In 2004, The Ministerial Summit on Health Research in Mexico City stated that, Research results must be published, documented in internationally accessible registers and archives, and synthesized through systematic reviews. These actions can help to inform decisions about support for new research and to build public confidence in science [62]. The Summit called for action by All major stakeholders, facilitated by the WHO Secretariat, to establish a platform linking a network of international clinical trials registers to ensure a single point of access and the unambiguous identification of trials.. In 2008, the Global Ministerial Forum on Research For Health in Bamako agreed To develop, set, and enforce standards, regulations, and best practices for fair, accountable, and transparent research processes and the registration and results reporting of clinical trials, and open and equitable access to research data, tools, and information [62, 63].. In 2010, the World Bank announced that it ...
In a clinical trial, participants receive specific interventions according to the research plan or protocol created by the investigators. These interventions may be medical products, such as drugs or devices; procedures; or changes to participants behavior, such as diet. Clinical trials may compare a new medical approach to a standard one that is already available, to a placebo that contains no active ingredients, or to no intervention. Some clinical trials compare interventions that are already available to each other. When a new product or approach is being studied, it is not usually known whether it will be helpful, harmful, or no different than available alternatives (including no intervention). The investigators try to determine the safety and efficacy of the intervention by measuring certain outcomes in the participants. For example, investigators may give a drug or treatment to participants who have high blood pressure to see whether their blood pressure decreases.. ...
In a dose-finding clinical trial, you have a small number of doses to test, and you hope find the one with the best response. Here "best" may mean most effective, least toxic, closest to a target toxicity, some combination of criteria, etc.. Since your goal is to find the best dose, it seems natural to compare dose-finding methods by how often they find the best dose. This is what is most often done in the clinical trial literature. But this seemingly natural criterion is actually artificial.. Suppose a trial is testing doses of 100, 200, 300, and 400 milligrams of some new drug. Suppose further that on some scale of goodness, these doses rank 0.1, 0.2, 0.5, and 0.51. (Of course these goodness scores are unknown; the point of the trial is to estimate them. But you might make up some values for simulation, pretending with half your brain that these are the true values and pretending with the other half that you dont know what they are.). Now suppose youre evaluating two clinical trial designs, ...
Discover and participate in Cancer Clinical Trials through the UNC REX Cancer Care. Call 919-784-7209 to learn about available trials.
Given a potentially huge set of candidate criteria, our goal is to help users choose the most appropriate criteria from among the candidates. In this work, we assume that the candidate criteria exist in some document(s) in a given repository, either separately from different documents or together in the same document, and our technical objective is to rank these candidates according to their appropriateness to the task at hand. As mentioned previously, such task would be to put together a clinical trial protocol about some particular disease, treatment, or drug.. To provide a concrete idea of our problem, the following is a snippet of a clinical trial protocol, downloaded from the clinical trials website http://www.clinicaltrials.gov, and modified for presentation as an example. It shows the title, the objective of the clinical trial as well as the inclusion and exclusion criteria.. Title: Antioxidant Systems and Age-Related Macular Degeneration Objective:. The objective of this study is to ...
TY - JOUR. T1 - Limited Generalizability of Registration Trials in Hepatitis C. T2 - A Nationwide Cohort Study. AU - Berden, Floor A C. AU - de Knegt, Robert J. AU - Blokzijl, Hans. AU - Kuiken, Sjoerd D. AU - van Erpecum, Karel J L. AU - Willemse, Sophie B. AU - den Hollander, Jan. AU - van Vonderen, Marit G A. AU - Friederich, Pieter. AU - van Hoek, Bart. AU - van Nieuwkerk, Carin M J. AU - Drenth, Joost P H. AU - Kievit, Wietske. PY - 2016. Y1 - 2016. N2 - BACKGROUND: Approval of drugs in chronic hepatitis C is supported by registration trials. These trials might have limited generalizability through use of strict eligibility criteria. We compared effectiveness and safety of real world hepatitis C patients eligible and ineligible for registration trials.METHODS: We performed a nationwide, multicenter, retrospective cohort study of chronic hepatitis C patients treated in the real world. We applied a combined set of inclusion and exclusion criteria of registration trials to our cohort to ...
Cervical Dystonia (CD) is a condition associated with abnormal movements of the neck and head, which may result in considerable pain and discomfort. Academic Network conducted a clinical trial recruitment campaign for a new medication for CD by a
By Phyllis Griffin Epps The Food and Drug Administration (FDA) is finalizing guidelines that would recommend the use of racial and ethnic categories in clinical drug trials and the submission of data regarding the safety and efficacy of pharmaceutical products subject to FDA approval. The draft guidance, titled Guidance for Industry: Collection of Race and Ethnicity Data in Clinical Trials (http://www.fda.gov/OHRMS/DOCKETS/98fr/03-2162.pdf ) and issued in January 2003, has as its premise the 1998 final rule of Investigational New Drug Applications and New Drug Applications (the Demographic Rule ). 63 Federal Register 6854 (Feb. 11, 1998) (codified at 21 CFR 312.33(a) (2) and 21 CFR 314.50(d) (5)). A commentary on the Demographic Rule, which requires sponsors of New Drug Applications to include an analysis of data according to demographic subgroups, the draft guidance recommends use of the categories developed by the Office of Management and Budget ( OMB ) to standardize the collection and use of ...
Conducting research - including clinical trials - has increasingly become more and more globalized, with US-based sponsors showing interest in holding clinical trials abroad. In addition, with the current trend towards patient-centricity and the drive to establish trial sites where the patients are, pharmaceutical companies and contract research organizations (CRO) are realizing the challenges in understanding international clinical trial regulations, and ensuring compliance.. The European Union (EU) in particular, offers a number of advantages for clinical trial coordinators, including newly-released International Conference on Harmonisation Good Clinical Practices (ICH GCP E6) guidelines designed to allow sponsors to submit one application which encompasses all EU countries involved in a proposed trial. Unfortunately, dealing with European regulators - such as the European Medicines Agency (EMA) - can be very different compared to what clinical trial professionals are used to with the US Food ...
Considerable therapeutic advances for the treatment of vasculitis of the young have been made in the past 10 years, including the development of outcome measures that facilitate clinical trial design. Notably, these include: a recognition that some patients with Kawasaki Disease require corticosteroids as primary treatment combined with IVIG; implementation of rare disease trial design for polyarteritis nodosa to deliver the first randomised controlled trial for children; first clinical trials involving children for anti-neutrophil cytoplasmic antibody (ANCA) vasculitis; and identification of monogenic forms of vasculitis that provide an understanding of pathogenesis, thus facilitating more targeted treatment. Robust randomised controlled trials for Henoch Schönlein Purpura nephritis and Takayasu arteritis are needed; there is also an over-arching need for trials examining new agents that facilitate corticosteroid sparing, of particular importance in the paediatric population since glucocorticoid
Full Text CA-96-016 MINORITY-BASED COMMUNITY CLINICAL ONCOLOGY PROGRAM NIH GUIDE, Volume 25, Number 20, June 21, 1996 RFA: CA-96-016 P.T. 34, FF Keywords: Autoimmunity Oncology Disease Prevention+ Treatment, Medical+ Clinical Trial National Cancer Institute Letter of Intent Receipt Date: August 7, 1996 Application Receipt Date: September 25, 1996 PURPOSE The Division of Cancer Prevention and Control (DCPC), National Cancer Institute (NCI), is continuing the established cancer control effort, which involves practicing oncologists who serve large minority populations in the NCI clinical trials program. The Community Oncology and Rehabilitation Branch (CORB), DCPC, invites applications from domestic institutions with greater than 50 percent of new cancer patients from minority populations for cooperative agreements in response to this Minority-Based Community Clinical Oncology Program (Minority-Based CCOP) Request for Applications (RFA). Applicants for new and currently funded Minority-Based CCOPs ...
Note: The corresponding author had full access to all the data and had final responsibility for the decision to submit the manuscript for publication.. Grant Support: By grants R01DA035808 and P30DA040500 from the National Institute on Drug Abuse (NIDA) of the National Institutes of Health (NIH); U10DA013046, UG1/U10DA013035, UG1/U10DA013034, U10DA013045, UG1/U10DA013720, UG1/U10DA013732, UG1/U10DA013714, UG1/U10DA015831, U10DA015833, HHSN271201200017C and HHSN271201500065C from the NIDA National Drug Abuse Treatment Clinical Trials Network; and K24DA022412 (to Dr. Nunes).. Disclosures: Dr. Murphy reports grants from NIH during the conduct of the study. Ms. Novo reports grants from NIDA during the conduct of the study and outside the submitted work. Dr. Rotrosen reports grants from NIDA/NIH, medication for the present study from Indivior, and medication and/or funds for other studies (as principle investigator or investigator) from Indivior and Alkermes. Authors not named here have disclosed no ...
RnRMarketResearch.com adds report "B-Cell Non-Hodgkin Lymphoma Global Clinical Trials Review, H1, 2014" to its store.. B-Cell Non-Hodgkin Lymphoma Global Clinical Trials Review, H1, 2014. Summary. GlobalDatas clinical trial report, "B-Cell Non-Hodgkin Lymphoma Global Clinical Trials Review, H1, 2014″ provides data on the B-Cell Non-Hodgkin Lymphoma clinical trial scenario. This report provides elemental information and data relating to the clinical trials on B-Cell Non-Hodgkin Lymphoma. It includes an overview of the trial numbers and their recruitment status as per the site of trial conduction across the globe. The databook offers a preliminary coverage of disease clinical trials by their phase, trial status, prominence of the sponsors and also provides briefing pertaining to the number of trials for the key drugs for treating B-Cell Non-Hodgkin Lymphoma. This report is built using data and information sourced from proprietary databases, primary and secondary research and in-house analysis ...
Safer and more effective clinical trials. Evolution[edit]. This section may stray from the topic of the article. Please help ... "Journal of Evaluation in Clinical Practice. 18 (1): 56-62. doi:10.1111/j.1365-2753.2010.01522.x. ISSN 1365-2753. PMID 20698917. ...
ongoing microbicide clinical trials "avac" Check ,url= value (help). Retrieved October 2010. Check date values in: ,access-date ... permanent dead link] World Health Organization (2002). "HIV/AIDS Topics: Microbicides". Geneva: World Health Organization. ... Additionally, clinical trials have not demonstrated these agents to be effective at preventing HIV transmission.[citation ... See Carrageenan#Medical Uses The phase III clinical trial for carrageenan-based Carraguard showed that it had no statistical ...
Topics in Magnetic Resonance Imaging. 25 (1): 31-37. doi:10.1097/RMR.0000000000000076. "Clinical Trials". Janine M. Lupo; ... The majority of clinical studies utilizing 13C hyperpolarization are currently studying pyruvate metabolism in prostate cancer ...
... clinical research including clinical trials; endocrinology; epidemiology and prevention; experimental therapeutics, molecular ... Some of the topics include biochemistry; chemical, physical, and viral carcinogenesis and mutagenesis; ... Based in Philadelphia, the AACR focuses on all aspects of cancer research, including basic, clinical, and translational ... The journal publishes significant, original studies, reviews, and perspectives on all areas of basic, clinical, translational, ...
Clinical Cancer Research; Clinical Trials. 6 (7): 2677-84. PMID 10914709. Avendano, Carmen; Menendez, J. Carlos (April 2008). ... "Oral Complications of Chemotherapy and Head/Neck Radiation". Cancer Topics - Coping with Cancer. National Cancer Institute. ... In clinical trials for mesothelioma, folic acid and B12 supplementation reduced the frequency of adverse events.) It is also ... NCCN Clinical Practice Guidelines in Oncology: Non-small Cell Lung Cancer V.2.2009 available from www.nccn.org Azzoli CG, Kris ...
Lechat, P. (2008). "Clinical pharmacology of beta-blockers in cardiology: trial results and clinical applications". Hot Topics ... Clinical trials started in the summer of 1964 and a year later, propranolol was launched under the trade name Inderal, only two ... The launch took place in November 1963 when many small-scale clinical trials had proved their effectiveness in angina and ... Although DCI had no clinical utility, a change in the compound did provide a clinical candidate, pronethalol, which was ...
It was in phase II clinical trials in 2008 but appears to have been discontinued as it is no longer in the company's ... Teegarden BR, Al Shamma H, Xiong Y (2008). "5-HT(2A) inverse-agonists for the treatment of insomnia". Current Topics in ... "Efficacy Study of LY2422347 to Treat Insomnia - Full Text View - ClinicalTrials.gov". "Eli Lilly and Company » Research ...
Clinical trials have been initiated to test the effectiveness of certain worms in treating some allergies. It may be that the ... For more information on this topic, see Helminthic therapy. In the early stages of allergy, a type I hypersensitivity reaction ... The authors concluded that, based on rigorous clinical trials of all types of homeopathy for childhood and adolescence ailments ... systematic review of randomized clinical trials". Mayo Clin. Proc. 82 (1): 69-75. doi:10.4065/82.1.69. PMID 17285788. "Archived ...
Karonudib, an MTH1 inhibitor, is currently being evaluated a phase I clinical trial for safety and tolerability. A potent and ... Research into this topic is ongoing. MTH1 is a potential drug target to treat cancer, however there are conflicting results ... This makes it a topic of interest in cancer research, both as a potential method for healthy cells to prevent cancer and a ... "MTH1, A Phase I, Study on Tumors Inhibition, First in Human, First in Class (MASTIFF)". ClinicalTrials.gov. U.S. National ...
See Trivia, and avoid useless statements like "More research is needed". Wikipedia is not a directory of clinical trials or ... To create a new topic, slick [new section] at the top of the page, give the section a title, and leave your comment. New topics ... For example, the results of an early-stage clinical trial are unlikely to be appropriate for inclusion in the Treatment section ... In medicine, primary sources include clinical trials, which test new treatments; secondary sources include meta-analyses, which ...
... which are much higher than those seen in randomized clinical trials[62] have been the topic of extensive debate and discussion. ... The author of one study argued that adverse events are more common in clinical practice than in randomized clinical trials.[56] ... Norata GD, Tibolla G, Catapano AL (October 2014). "Statins and skeletal muscles toxicity: from clinical trials to everyday ... Randomized controlled trials have found these foodstuffs to reduce circulating cholesterol, but the quality of the trials has ...
... results of clinical trials, and research findings. Ophthalmology also publishes major reviews of specific topics by ... Topics include new diagnostic and surgical techniques, treatment methods, instrument updates, the latest drug findings, ...
... clinical trials; health and adverse effects; fortification; traditional Chinese medicine and other folk/ethnic supplement ... The subset will retrieve dietary supplement-related citations on topics including, but not limited to: chemical composition; ...
In addition to Hantavax three more vaccine candidates have been studied in I-II stage clinical trials. They include a ... List of vaccine topics Seoul virus Gou virus Vaccine-naive Schmaljohn, C. S. (2012). "Vaccines for hantaviruses: Progress and ... Field trial of an inactivated vaccine against hemorrhagic fever with renal syndrome in humans. Arch Virol. 1990;1(Suppl):35-47 ... "Phase 2a Immunogenicity Study of Hantaan/Puumala Virus DNA Vaccine for Prevention of Hemorrhagic Fever". ClinicalTrials.gov. ...
For example, results of an early-stage clinical trial would not be appropriate in the Treatment section on a disease because ... which can be useful when outlining a topic. Systematic reviews use sophisticated methodology to address a particular clinical ... In medicine, primary sources include clinical trials, which test new treatments. Broadly speaking, reviews may be narrative or ... Some systematic reviews also include a statistical meta-analysis to combine the results of several clinical trials to provide ...
Since 1992, the journal has published the proceedings of Outcome Measures in Rheumatoid Arthritis Clinical Trials (OMERACT) ... The Journal of Rheumatology is a peer-reviewed medical journal addressing topics in rheumatology and arthritis. It is an ...
From the information technology perspective for clinical trials, it has been guided by another U.S. Food and Drug ... the topic is frequently encountered by its users. Various industrial guidances and commentaries are available for people to ... "Guidance for Industry: Computerized Systems Used in Clinical Trials" (PDF). U.S. Food and Drug Administration. April 1999. ...
Kowey said the book's main weakness was a lack of focus on clinical issues - both in topics covered and author selection. He ... examines drugs in clinical trial at the time of publication. The chemical structure of existing drugs is not covered. Overall, ... noted that bringing drugs to the marketplace is expensive and proof of concept clinical trials are necessary to justify the ... Its 21 chapters cover a variety of topics related to cardiac arrhythmia and electrophysiology, primarily reviewing known ...
... whereas a clinical trial case will typically be assessed for causality by the clinical trial investigator and/or the license ... The CIOMS, a part of the WHO, is a globally oriented think tank that provides guidance on drug safety related topics through ... The variables in a clinical trial are specified and controlled, but a clinical trial can never tell you the whole story of the ... Also known as SAE (serious adverse event) reporting from clinical trials, safety information from clinical studies is used to ...
... and diagnostic laboratory companies with the design and execution of clinical research trials. Ranked #241 on the 2015 Inc. 500 ... In 2009, Ouriel made speeches to medical professionals about such topics as retaining patients and public-private partnerships ... multicenter randomized trial of clot busting therapy in the New England Journal of Medicine in 1998. In 1998, he was recruited ... "snapshot of the facility's clinical strengths and weaknesses"; he favors transparency. Ouriel facilitated the development of ...
Discussion topics when setting up an experimental designEdit. An experimental design or randomized clinical trial requires ... James Lind carried out a systematic clinical trial to compare remedies for scurvy.[1] This systematic clinical trial ... Systematic clinical trialsEdit. This section possibly contains original research. Please improve it by verifying the claims ... Some of the following topics have already been discussed in the principles of experimental design section:. *How many factors ...
They work together to assess the evidence for the guideline topic (e.g. clinical trials of competing products) before preparing ... Before an appraisal, the Advisory Committee on Topic Selection (ACTS) draws up a list of potential topics of clinical ... It was set up as the National Institute for Clinical Excellence in 1999, and on 1 April 2005 joined with the Health Development ... The idea of what was originally termed a National Institute for Clinical Excellence took root when Labour came to power having ...
Reviewing clinical trials involving phytosterol supplementation, the FDA concluded that when consumed in the range of 1 to 3 ... Patterson, CA (July 2006). "Phytosterols and stanols: Topic 10075E" (PDF). Agriculture and Agri-Food Canada, Government of ... Plant sterols and stanols, when compared head to head in clinical trials, have been shown to equally reduce cholesterol levels ... Trials looking at high doses (> 4 g/day) of plant sterols or stanols are very limited, and none have yet to be completed ...
... as well as clinical trials. The Journal of Biological Rhythms covers topics in chronobiology, namely circadian and seasonal ... Early research topics included "splitting," circannual rhythmicity, photoperiodic time measurement, and circadian pacemaker ... The journal also publishes special publication collections consisting of selected articles on a chosen topic. These collections ...
A variety of approaches are explored by the journal including: genetic, behavioral, modeling, and clinical trials. In 2015 SAGE ... The JBR publishes scholarly articles, original research, and reviews on a variety of topics all centering around periodicity in ...
The earliest publication of a controlled clinical trial appears to be from 1945.[27] Researchers continued to work on this ... started publishing research on the topic and also published a book "Vitamin C and the Common Cold" in 1970.[28] A revised and ... A meta-analysis of 44 clinical trials has shown a significant positive effect of vitamin C on endothelial function when taken ... cannot be recommended outside of a clinical trial."[43] A 2015 review added: "There is no high-quality evidence to suggest that ...
Clinical observations[edit]. A study involving 2408 donors (18-60 years) indicated that bone pain (primarily back and hips) as ... "The Only Real Cure Out There, for Now " Archived 30 May 2008 at the Wayback Machine.. CLL Topics, Inc. ... "Adverse events among 2408 unrelated donors of peripheral blood stem cells: results of a prospective trial from the National ... 2008). "Clinical applications of blood-derived and marrow-derived stem cells for nonmalignant diseases". JAMA. 299 (8): 925-36 ...
... interventions that are being tested for weight management in overweight and obese adults in primary care clinical trials.[ ... She contributed to several other topics, including the investigation of the influence of socioeconomic status and stress on ... She completed her PhD in 1986, and in 1987 was promoted to senior lecturer in clinical psychology and consultant clinical ... Jane Wardle FBA FMedSci (30 October 1950 - 20 October 2015) was a professor of clinical psychology and director of the Cancer ...
Please find clinical trials at HSS listed by the following topics or view the full directory. ... APS ACTION (Antiphospholipid Syndrome Alliance for Clinical Trials and International Networking) International Clinical ... Please visit the Mary Kirkland Center for Lupus Research and the Lupus Clinical Trials Consortium for more information on lupus ... Non-orthopedic and non-rheumatologic clinical trials are conducted at Weill Cornell Medical College, an affiliate of Hospital ...
Clinical Applications of Stem Cell Research. Catriona Jamieson. November 11, 2009 Program: Stem Cell Meeting on the Mesa 2009. ...
U.S. NIH: Stem Cell Information: Clinical Trials. *U.S. FDA: FDA Warns About Stem Cell Therapies ...
As the vast majority of drugs tested in small animal cancer models fail in human clinical trials, there is a need for large ... Utilization of large animal models also allows for testing of the same devices and tools used in human clinical practice in ... animal models to translate results obtained in small animal models to human clinical practice. In addition, the majority of ... futuristic perspectives with respect to the emerging requirements of large animal cancer models to address unmet clinical needs ...
... laboratories involved in vaccine and therapeutic clinical trials form an important part of clinical trial quality assurance. ... Impact of Funding Source on Clinical Trial Results Including Cardiovascular Outcome Trials.  Khan, MS; Krasuski, Richard ... committees in clinical trials sponsored by the pharmaceutical industry differ from those of trials sponsored by government. ... A model for harmonizing flow cytometry in clinical trials.  Amos, M; Aranda, R; Banchereau, J; Boshoff, C; Braun, J; Cho, J; ...
Clinical Trials as Topic Colitis, Ulcerative - drug therapy Double-Blind Method Enema Female Humans Male Mesalamine Proctitis ... Clinical Trials as Topic Denmark Humans Netherlands PubMed ID. 22745975 View in PubMed ... Clinical Trials as Topic Crohn Disease - drug therapy Drug Evaluation Humans Metronidazole - therapeutic use Sulfasalazine - ... Clinical Trials as Topic Denmark Femoral Fractures - blood - epidemiology - etiology Great Britain Humans ...
Exploratory Clinical Trials of Mind and Body Interventions for NCCAM High Priority Research Topics (R34) PAR-14-182. NCCIH ... Exploratory Clinical Trials of Mind and Body Interventions for NCCAM High Priority Research Topics (R34) ... The clinical significance and, when applicable, the biological relevance of the future clinical trial must be clearly stated. ... Future Clinical Trial: A concise summary of the subsequent proposed trial should be provided including the study design ( ...
Research on Current Topics in Alzheimers Disease and Its Related Dementias (R01 Clinical Trial Optional) PAR-18-596. NIA ... In addition, for applications proposing clinical trials. Are the scientific rationale and need for a clinical trial to test the ... When involving NIH-defined human subjects research, clinical research, and/or clinical trials (and when applicable, clinical ... For trials focusing on clinical or public health endpoints, is this clinical trial necessary for testing the safety, efficacy ...
Clinical Trials, Phase II as Topic*Clinical Trials, Phase II as Topic ... "Clinical Trials, Phase II as Topic" by people in this website by year, and whether "Clinical Trials, Phase II as Topic" was a ... "Clinical Trials, Phase II as Topic" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ... Below are the most recent publications written about "Clinical Trials, Phase II as Topic" by people in Profiles. ...
Female Contraceptive Trials Topic Area). Access many more Professional, Administrative, Management, Special Studies Awards , ...
3rd KCE Trials symposium - Hot Topics in Clinical Trials: Developing Research Agendas, New Methods in Trials and Trial Data ... 3rd KCE Trials symposium - Hot Topics in Clinical Trials: Developing Research Agendas, New Methods in Trials and Trial Data ... KCE Trials invites you to subscribe to the Symposium: Hot Topics in Clinical Trials: Developing Research Agendas, New Methods ... Status and impact of sharing of clinical trial data. Christian Ohmann, ECRIN, formerly University of Duesseldorf, Clinical ...
I am unable to find this clinical trial on MK 3475 in US - only available in Australia in the clinicaltrials.gov website. Is ... Update on my anti-PD-1 clinical trial (MK 3475): I had my twelve-week scans this week. Everyone, including the doctors, trial ... Anti-PD-1 Immunotherapy Clinical Trial Update Portal › Forums › Lung/Thoracic Cancer › NSCLC › Stage IV NSCLC › Anti-PD-1 ... There was an earlier discussion of comparable trials here:. http://cancergrace.org/lung/topic/pd-1-clinical-studies-bms-vs-mk/ ...
A summary of clinical trial results is insufficient. The scientific data generated in clinical trials data are a public good. ... Transparent, independent health authorities: The worldwide debate on access to clinical trial data. Clinical trials regulation ... Access to all the data from clinical trials, in the form of clinical study reports, is crucial to ensure the reliability of ... Transparency in the public interest: How the EMA policy on publication and access to clinical-trial data could help save lives ...
... 0-9. A. B. C. D. E. F. G. H. I. J. K. L. M. N. O. P ... Meeting on the Revision of Guidelines for Clinical Research on Acupuncture, Seoul, Republic of Korea, 24-26 August 2005 : ...
In the Nov. 10 SN: Real benefits of virtual therapy, monkey malaria in humans, round electrons disappoint, mouse pups with two dads, bats hover techniques, Europas icy spikes, a vampire burial and more. ...
In the June 8 SN: Measles roars back, collapsars spin gold, a new kind of dementia, the Southern Oceans secrets, Denisovans lived on top of the world, and more. ...
Clinical trials registration. The mission of the WHO International Clinical Trials Registry Platform (ICTRP) is to ensure that ... Research policy topics. Strategy on research for health. WHO is currently working on a Research Strategy. The paper will focus ... IGPH aims to provide information and facilitate the application of genomics-based knowledge and technologies in clinical and ...
Clinical trials test how well new medical approaches work in people. Read more. ... Page last updated on 20 March 2020 Topic last reviewed: 18 May 2018 ... Informed Consent (Clinical Trials) (National Cancer Institute) Also in Spanish * Minorities in Clinical Trials Fact Sheet (Food ... NIH Clinical Research Trials and You (National Institutes of Health) * What Are Clinical Trials and Studies? (National ...
FDA and University of Maryland CERSI Lecture on Ensuring Accuracy in Clinical Trial Publications: Weighing Options by Peter ... Doshis lecture, he and a colleague have published an editorial on this topic in The BMJ:. PDoshi and FGodlee, The wider role ... particularly publications of clinical trials - is in doubt, so too are standards of care, clinical practice guidelines, and ... He is an advocate for greater public access to clinical trial data. Dr. Doshi also has strong interests in journalism as a ...
Clinical Trial Considerations: Vertebral Augmentation Devices to Treat Spinal Insufficiency Fractures (PDF Version) ... This guidance document represents the Food and Drug Administrations (FDAs) current thinking on this topic. It does not create ... Clinical Trial Considerations: Vertebral Augmentation Devices to Treat Spinal Insufficiency Fractures - Guidance for Industry ... Clinical Trial Considerations: Vertebral Augmentation Devices to Treat Spinal Insufficiency Fractures - Guidance for Industry ...
Oxygen Therapy: MedlinePlus Health Topic (National Library of Medicine) Also in Spanish ... Article: Clinical and imaging characteristics of hematologic disease complicated by air leak... ... Pulmonary Rehabilitation: MedlinePlus Health Topic (National Library of Medicine) Also in Spanish ... Page last updated on 30 April 2020 Topic last reviewed: 3 January 2017 ...
"Clinical tests showed that hardware and software could be adjusted to the specific characteristics of these subjects providing ... "Clinical tests showed that hardware and software could be adjusted to the specific characteristics of these subjects providing ... Specifically, all subjects who had been mobile before the trial seemed to improve their walking speed and/or balance during ...
Clinical trials to test new drugs, devices or treatments are not only expensive, they are also risky for the test subjects; ... clinical trials.. "The primary users of in silico clinical trials technologies will be the biomedical industries", explains Dr ... Clinical trials to test new drugs, devices or treatments are not only expensive, they are also risky for the test subjects; ... "New medical treatments and devices are being tested in vitro - in a test system, and/or in vivo - clinical trials in living ...
Search our research on a range of topics like radiotherapy, drug discovery and immunotherapy. ... Clinical Trials Find out more about some of the clinical trials we support. Clinical trials are vital for improving cancer ... From studies of the intricate workings of molecules within cells to the results of large-scale clinical trials of treatments, ...
Conditions & Health Topics * Clinical Services & Specialties * Doctors & Researchers * Research Institutes, Divisions, and ... To learn more about available neuroblastoma clinical trials, contact us at [email protected] or 513-636-2799. ... PURPOSE: This phase I/II trial studies the side effects and best dose of talazoparib and temozolomide and to see how well they ... PURPOSE: This phase I/II trial studies the side effects and best dose of nivolumab when given with or without ipilimumab to see ...
  • Conflicts of Interest and Outcomes of Cardiovascular Trials. (duke.edu)
  • Objective To evaluate the impact of non-blinded outcome assessment on estimated treatment effects in randomised clinical trials with binary outcomes. (bmj.com)
  • Outcomes in most trials were subjective-for example, qualitative assessment of the patient's function. (bmj.com)
  • 1 One challenge to the validity of such trials is the tendency for assessments of outcomes to systematically deviate from the truth because of predispositions in observers, such as from hope or expectation. (bmj.com)
  • Amsterdam, the Netherlands and Washington, D.C. - Royal Philips (NYSE: PHG, AEX: PHIA) today announced that the results from two large clinical trials comparing patient outcomes using instant wave-free ratio (iFR) and fractional flow reserve (FFR) in the diagnosis and treatment of heart disease have been published in the New England Journal of Medicine. (philips.com)
  • Despite the critical relevance of smoking to cancer outcomes, most oncology clinical trials do not collect data on smoking history and status unless the malignancy is widely acknowledged as smoking related (e.g., lung or head and neck cancer). (aacrjournals.org)
  • Changes in smoking status during treatment or follow-up are monitored in very few trials and are infrequently reported in sample descriptions or included in analysis plans as a potential moderator of outcomes. (aacrjournals.org)
  • Based on mounting evidence that tobacco use affects cancer treatment outcomes and survival, we recommend that smoking history and status be systematically collected as core data in all oncology clinical trials: at diagnosis, at trial registration, and throughout treatment and follow-up to long-term survival or death. (aacrjournals.org)
  • We feel that the inclusion and analysis of such data in clinical trials will add important information to the interpretation of outcomes and the development of scientific knowledge in this area. (aacrjournals.org)
  • Also eligible are biomarker- and outcomes-validation studies that are immediately preparatory to trials in stroke prevention, treatment, or recovery. (sbir.gov)
  • Nonsevere acute otitis media: a clinical trial comparing outcomes of watchful waiting versus immediate antibiotic treatment. (greenmedinfo.com)
  • Objectives: The aim of this article is to provide recommendations on the structure, materials, and outcomes that should be adopted for communication training programs designed to improve clinical trial education for patients. (intechopen.com)
  • Discussions about clinical trial participation are quite challenging due to the uncertainty regarding the outcomes of clinical trials, and the complex nature of consent documents [ 12 ]. (intechopen.com)
  • Radiological imaging has an important role in evaluating CLL and validating therapeutic agent response assessment outcomes in clinical trials. (parexel.com)
  • If income is associated with health status, then improving representativeness of lower-income patients in trials would improve the generalizability of study outcomes. (breastcancer.org)
  • As the vast majority of drugs tested in small animal cancer models fail in human clinical trials, there is a need for large animal models to translate results obtained in small animal models to human clinical practice. (frontiersin.org)
  • Utilization of large animal models also allows for testing of the same devices and tools used in human clinical practice in species with similar size, anatomy, physiology, metabolism, immunology, and genetics compared to humans. (frontiersin.org)
  • IGPH aims to provide information and facilitate the application of genomics-based knowledge and technologies in clinical and public health practice. (who.int)
  • When the completeness or accuracy of the medical literature - particularly publications of clinical trials - is in doubt, so too are standards of care, clinical practice guidelines, and systematic reviews. (fda.gov)
  • The affirmative decision of the IRB that the clinical trial has been reviewed (i.e. protocol, informed consent(s), conflict of interests, etc.) and may be conducted at the institution site within the constraints set forth by the IRB, the institution, good clinical practice (GCP), and the applicable regulatory requirements. (lymphedemapeople.com)
  • He is a Director of the Scientific Archivists Group, Co-Lead for the SAG GCP Special Interest Group, and former Executive Committee Member of the Good Clinical Practice Records Managers Association, promoting latest developments, trends, industry best practices and standards in the life sciences sector. (smi-online.co.uk)
  • We provide a suggested set of items for inclusion in clinical trial data sets that also are useful in clinical practice. (aacrjournals.org)
  • With an expanding portfolio of immune therapies, the company is advancing a growing preclinical and clinical stage product pipeline. (marketwatch.com)
  • The network is designed to increase the efficiency of stroke clinical trials by facilitating patient recruitment and retention, supporting novel methodologies and streamlined approaches to accelerate the development of promising stroke therapies, and enabling comparison between approaches. (sbir.gov)
  • Conflicts of interests have long been recognized as potential sources of influence in the conduct and reporting of clinical trials. (duke.edu)
  • Whether FDA recommends that you conduct a clinical study depends on how significantly different your material or formulation is from those of devices we have cleared for the same intended use. (fda.gov)
  • CCTN was established in 1996 to support research on male and female contraception and to conduct clinical trials of new contraceptive drugs and devices. (nih.gov)
  • PURPOSE: To identify areas of concern regarding the conduct of phase I trials, the perceived expectations and motivations of the parents of children entered, the expectations of toxicity and benefit, and the ethical concerns of pediatric hematologists and oncologists in the United Kingdom and North America. (isharonline.org)
  • Once a clinical study is completed, the clinical study records are the primary - and often the only - evidence of clinical study activities, which are critical to permitting evaluation of the conduct of the study and the quality of the data produced. (smi-online.co.uk)
  • In this issue of Mind the Brain, I demonstrate a quick assessment of the conduct and reporting of a clinical trial. (plos.org)
  • Although restrictions exist to protect trade secrets, a company's competitive position, confidential information or other proprietary material, those laws aren't a blank cheque to refuse disclosure of clinical trials or safety data, Prof. Herder said. (theglobeandmail.com)
  • 1 We suggest a scoring system for pooling this evidence and detail how this may be combined with hypothetical scenarios to assist in the design of, and justification for, a small randomised controlled trial. (bmj.com)
  • Preliminary results from one of the earliest clinical trials of CRISPR-Cas9 provide evidence that the technique is safe and feasible to use for treating human diseases. (bioportfolio.com)
  • When implementing a trial, try if you can to leave a clear audit trail of who had access to what evidence at which point in the trial. (cytel.com)
  • Clinical trials are the gold standard in medical evidence and crucial for developing new treatment options for the 13.8 million Americans currently battling cancer. (ibm.com)
  • Design Systematic review of trials with both blinded and non-blinded assessment of the same binary outcome. (bmj.com)
  • Becoming a successful clinical trial investigator : a step by step guide for developing a clinical trial site / P.K. Julka. (who.int)
  • She has led trials - Dr. Valerie Arnold, that have led to approval of well-known medicaprincipal investigator, CNS Healthcare tions such as Ambien, Wellbutrin and Lyrica. (issuu.com)
  • The Alliance works with partner organizations and government agencies such as FDA and NIH to increase older adult participation in clinical trials, including for diseases such as Alzheimer's disease. (agingresearch.org)
  • Due to the lack of other treatment options, patient candidates for participation in phase I clinical trials are considered the most vulnerable, and many ethical concerns have emerged regarding the informed consent process used in the experimental design of such trials. (isharonline.org)
  • Trials will provide "informed consent," which is what you need to know before you sign up. (webmd.com)
  • Advancing healthcare policy : Transparent, independent health authorities, Clinical trials regulation: choose transparency! (prescrire.org)
  • FDA scientists have unique insights into this problem and unique abilities to do something about it, in doing so both improving clinical care and promoting more prudent use of healthcare resources. (fda.gov)
  • This will reduce the costs and the risks (both clinical and financial) involved in trials, and it will ultimately increase the rate of innovation in healthcare. (europa.eu)
  • The biotech medicine is the first plant-produced antibody to be greenlit for clinical testing by Britain's Medicines and Healthcare products Agency . (zdnet.com)
  • New Drug Development: An Introduction to Clinical Trials, 2nd Edition' is a solid introduction to the process of drug development, with an emphasis on clinical research, especially the statistical aspects. (springer.com)
  • The NIH StrokeNet comprises a National Clinical Coordinating Center (NCC), a National Data Management Center (NDMC) and 25 geographically distributed Regional Coordinating Centers (RCC) with over 350 affiliated stroke centers. (sbir.gov)
  • A randomized clinical trail led by Huntsman Cancer Institute investigators finds that a combinatorial chemotherapy reduces precancerous polyps by 75 percent in patients at high-risk for cancer. (utah.edu)
  • This implies trial sizes that are unrealistically large for rare cancers. (bmj.com)
  • Overdiagnosis - it's been estimated that in this trial around 1 in 5 lung cancers detected by low dose CT were overdiagnosed. (cancerresearchuk.org)
  • Complexities in sample handling, instrument setup and data analysis are barriers to the effective use of flow cytometry to monitor immunological parameters in clinical trials. (duke.edu)
  • Identifying Barriers and Practical Solutions to Conducting Site-Based Research in North America: Exploring Acute Heart Failure Trials As a Case Study. (duke.edu)
  • While these end points may be reasonable surrogates for the clinical effectiveness of drugs, a key point in their use as trial end points is the definition of a relevant duration of antiviral response. (ovid.com)
  • Attendees gather to discuss over 6,000 abstracts and to hear more than 250 invited presentations on significant discoveries in basic, clinical, and translational cancer research. (wikipedia.org)
  • He is an advocate for greater public access to clinical trial data. (fda.gov)
  • Ginny Barbour, Medicine Editorial Director at PLOS, discusses a recently-published UK Government spending report on access to clinical trial information and the stockpiling of Tamiflu. (plos.org)
  • Clinical trials may also compare a new treatment to a treatment that is already available. (medlineplus.gov)
  • Randomised controlled trials are regarded as the standard when comparing a new treatment with the standard treatment for a particular cancer. (bmj.com)
  • Furthermore, even if a much larger treatment effect could be expected, estimates derived from the resulting (small) randomised controlled trial would lack the precision needed for clinical decisions. (bmj.com)
  • Any of the treatment groups in a randomized trial. (lymphedemapeople.com)
  • Physician-scientist Ping Chi develops clinical trials to personalize treatment for people with sarcoma. (mskcc.org)
  • Memorial Sloan Kettering doctors are constantly working to improve treatment for people with soft tissue sarcoma through clinical trials. (mskcc.org)
  • For instance, if the treatment helps, will you still be able to get it once the trial is over? (webmd.com)
  • For-profit organizations and non-profits other than Institutions of Higher Education may wish to consider applying through PAR-17-277 , NIH StrokeNet Clinical Trials for Stroke Treatment, Recover and Prevention Infrastructure Resource Access (X01). (sbir.gov)
  • Thus, it is expected that all multi-center clinical trials for stroke treatment, prevention, and recovery supported by NINDS will be considered for implementation through the NIH StrokeNet. (sbir.gov)
  • Some patients are reluctant to take part in clinical trials for fear of getting no treatment at all for their brain cancer. (webmd.com)
  • The only way to find out which treatment is best is by comparing them head-to-head in a clinical trial. (webmd.com)
  • This topic will tell you about the early testing, diagnosis, and treatment of colorectal cancer. (adventisthealthcare.com)
  • For example, a treatment recommendation that involves the possibility of enrolling in a clinical trial is fraught with uncertainty because patients are generally randomized into one of multiple treatment arms, and because the treatment itself is under study [ 13 ]. (intechopen.com)
  • Following clinical assessment and special investigations to confirm the diagnosis of EAPH, 28 athletes were randomly assigned to an oral fluid and Trendelenburg position (OT=14) or an intravenous fluid (IV=14) treatment group. (bmj.com)
  • As reported by the GAO , women have been underrepresented in NIH supported clinical research which lead to unidentified differences in treatment results between men and women when incurring a disease. (angrybearblog.com)
  • Doing clinical trials large enough to achieve adequate reductions in uncertainties about treatment effects. (jameslindlibrary.org)
  • In rare cases, clinical trial volunteers have been hurt by the treatment or procedure being tested. (breastcancer.org)
  • I was asked by the cancer specialist if I would be I interested in being part of a clinical trial using a particular type of radiotherapy treatment. (cancerresearchuk.org)
  • I was also told that as part of the trial I would be given continued care every 3 months and for up to 3 years after the treatment. (cancerresearchuk.org)
  • For example, a clinical trial for a new breast cancer treatment may require more than100 patients who meet specific criteria, such as a certain genetic marker, age range, tumor stage or treatment history. (ibm.com)
  • This Research Topic will also address training needs with regards to comparative pathology and the development of imaging standards to support relevant interpretation of findings and expedite the launch of human clinical trials. (frontiersin.org)
  • Being consistent and maintaining neutrality in a controlled environment is highly important when conducting a successful clinical trial. (issuu.com)
  • This Frontiers in Oncology Research Topic provides futuristic perspectives with respect to the emerging requirements of large animal cancer models to address unmet clinical needs. (frontiersin.org)
  • Everyone, including the doctors, trial nurses, and my family and friends, was very anxious to see the results, as I am the first of the lung cancer arm to get my scans at my clinic. (cancergrace.org)
  • Sutter Health patient Bob Murphy describes how a clinical trial helped change his life while battling lung cancer. (sutterhealth.org)
  • But trials carried out both in the UK and the US produced disappointing results - giving men regular chest x-rays didn't reduce the number of lung cancer deaths. (cancerresearchuk.org)
  • Several clinical trials were carried out to see if offering regular scans to certain people with no symptoms of lung cancer could find more cases at an early stage, when they are more likely to be treated successfully. (cancerresearchuk.org)
  • The trial involved more than 53,000 people at high risk from lung cancer - that's people over 50 who had smoked heavily over a long period. (cancerresearchuk.org)
  • Patients with severe arthritis who took abatacept with at least one other disease-modifying antirheumatic drug in six and 12-month clinical trials demonstrated statistically significant improvement in tender, swollen joints and other clinical measures compared with placebo. (arctichealth.org)
  • The purpose of this Funding Opportunity Announcement (FOA) is to invite applications proposing research on current topics in Alzheimer's disease and its related dementias. (nih.gov)
  • Provention Bio, Inc. PRVB, -4.93% is a clinical-stage biopharmaceutical company leveraging a transformational drug development strategy that is focused on the prevention or interception of immune-mediated disease. (marketwatch.com)
  • A patient at the Kennedy Krieger Institute in Baltimore, Darius is taking part in a clinical trial, designed to help cure the disease. (go.com)
  • The CEO of the ALF is also planning to trial a project which will place liver disease patients into the Reg4All system. (zdnet.com)
  • Due to the desire to both shorten the length and reduce the size of clinical trials in human immunodeficiency virus (HIV) disease, the use of surrogate end points such as HIV-1 RNA is becoming increasingly standard. (ovid.com)