Precise and detailed plans for the study of a medical or biomedical problem and/or plans for a regimen of therapy.
Techniques and strategies which include the use of coding sequences and other conventional or radical means to transform or modify cells for the purpose of treating or reversing disease conditions.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.

A multicomponent intervention to prevent delirium in hospitalized older patients. (1/2588)

BACKGROUND: Since in hospitalized older patients delirium is associated with poor outcomes, we evaluated the effectiveness of a multicomponent strategy for the prevention of delirium. METHODS: We studied 852 patients 70 years of age or older who had been admitted to the general-medicine service at a teaching hospital. Patients from one intervention unit and two usual-care units were enrolled by means of a prospective matching strategy. The intervention consisted of standardized protocols for the management of six risk factors for delirium: cognitive impairment, sleep deprivation, immobility, visual impairment, hearing impairment, and dehydration. Delirium, the primary outcome, was assessed daily until discharge. RESULTS: Delirium developed in 9.9 percent of the intervention group as compared with 15.0 percent of the usual-care group, (matched odds ratio, 0.60; 95 percent confidence interval, 0.39 to 0.92). The total number of days with delirium (105 vs. 161, P=0.02) and the total number of episodes (62 vs. 90, P=0.03) were significantly lower in the intervention group. However, the severity of delirium and recurrence rates were not significantly different. The overall rate of adherence to the intervention was 87 percent, and the total number of targeted risk factors per patient was significantly reduced. Intervention was associated with significant improvement in the degree of cognitive impairment among patients with cognitive impairment at admission and a reduction in the rate of use of sleep medications among all patients. Among the other risk factors per patient there were trends toward improvement in immobility, visual impairment, and hearing impairment. CONCLUSIONS: The risk-factor intervention strategy that we studied resulted in significant reductions in the number and duration of episodes of delirium in hospitalized older patients. The intervention had no significant effect on the severity of delirium or on recurrence rates; this finding suggests that primary prevention of delirium is probably the most effective treatment strategy.  (+info)

Can we cure indolent lymphomas? (2/2588)

The current consensus is that indolent lymphomas are incurable disorders. There are some indications that these malignancies are potentially curable. Indeed, not all indolent lymphomas are currently incurable. For example, patients with Ann Arbor stage I-II indolent lymphomas can experience long-term disease-free survival and probable cure. Also, from the available literature data, it seems that the achievement of a molecular complete remission is a desirable objective. Patients who achieve a persistently negative PCR state seldom relapse, whereas the opposite is true for persistently positive cases. In view of its excellent correlation with disease-free survival when examined serially in multiple blood or marrow samples, the PCR technique has the potential of providing a tumor marker that can be used as an early end point for clinical trials. By serving as an early surrogate end point, PCR could play an important role in expediting the development of new treatment strategies. Whether IFN is capable of increasing the molecular complete remission rate as measured by PCR is not known. However, it is clear that from the clinical standpoint, IFN has been able to increase 2-fold the length of remission in patients with advanced indolent lymphomas. In at least two studies, this has been associated with prolongation of survival. More intensive regimens such as alternating triple therapy, when used in combination with IFN, seem to have improved the quality of remissions as judged by the PCR assay. Finally, the site where the bcl-2 breakpoint occurs seems to have clinical significance. Those follicular lymphomas with germ-line bcl-2, in our experience, have behaved more aggressively than the others, and their failure-free survival seems different from the usual indolent lymphomas and more closely resembles the large cell lymphomas. Although the biological significance of this observation is not yet understood, this group might actually constitute a prognostically different subset with a more aggressive and perhaps more curable lymphoma. Whether the plateau observed in their failure-free survival curve will be maintained with more follow-up and whether they might be a curable subset remain to be determined.  (+info)

Low-molecular-weight heparin in outpatient treatment of DVT. (3/2588)

Patients with a diagnosis of acute deep venous thrombosis have traditionally been hospitalized and treated with unfractionated heparin followed by oral anticoagulation therapy. Several clinical trials have shown that low-molecular-weight heparin is at least as safe and effective as unfractionated heparin in the treatment of uncomplicated deep venous thrombosis. The use of low-molecular-weight heparin in an outpatient program for the management of deep venous thrombosis provides a treatment alternative to hospitalization in selected patients. Use of low-molecular-weight heparin on an outpatient basis requires coordination of care, laboratory monitoring, and patient education and participation in treatment. Overlapping the initiation of warfarin permits long-term anticoagulation. Advantages include a decreased incidence of heparin-induced thrombocytopenia and fewer episodes of bleeding complications. Future clinical trials evaluating the safety and efficacy of low-molecular-weight heparin in the treatment of complicated deep venous thrombosis will further define appropriate indications for use and strategies for outpatient management.  (+info)

Time course of respiratory decompensation in chronic obstructive pulmonary disease: a prospective, double-blind study of peak flow changes prior to emergency department visits. (4/2588)

The aim of this study was to look at changes in peak expiratory flow rates (PEFR) prior to emergency department visits for decompensated chronic obstructive pulmonary disease (COPD). It was designed as a prospective, double-blind study at the Albuquerque Veterans Affairs Medical Center. Twelve patients with an irreversible component of airflow obstruction on pulmonary function tests were assessed. At entry, all subjects were instructed in the use of a mini-Wright peak flow meter with electronic data storage. They then entered a 6-month monitoring phase in which they recorded PEFR twice daily, before and after bronchodilators. The meter displays were disabled so that the patients and their physicians were blinded to all values. Medical care was provided in the customary manner. Patients were considered to have respiratory decompensation if they required treatment for airflow obstruction in the Emergency Department (ED) and no other causes of dyspnea could be identified. Simple linear regression was used to model changes in PEFR over time. The 12 subjects had 22 episodes of respiratory decompensation during 1741 patient-days of observation. Two episodes could not be analysed because of missing values. Ten episodes in seven subjects were characterized by a significant linear decline in at least one peak flow parameter prior to presentation. The mean rates of change for the four daily parameters varied from 0.22% to 0.27% predicted per day (or 1.19 to 1.44 1 min-1 day-1). The average decrement in these parameters ranged from 30.0 to 33.8 1 min-1 (or 18.6%-25.9% of their baseline values). No temporal trends were found for the 10 episodes occurring in the other five subjects. We concluded that respiratory decompensation is characterized by a gradual decline in PEFR in about half of cases. Future studies should be done to elucidate the mechanisms of respiratory distress in the other cases.  (+info)

Enhancing the identification of excessive drinkers on medical wards: a 1-year follow-up study. (5/2588)

This paper describes a 1-year follow-up study examining whether hospital ward doctors and nurses continue to take quantitative alcohol histories and provide brief intervention to problem drinkers on general medical wards after the introduction of a simple protocol. Regular training in the use of this protocol was stipulated in the annual service contract between the Health Authority and the Hospital Trusts. Improvements in staff practice persisted at 1-year follow-up, although it fell from a peak at an earlier phase of the study. The positive role of state purchasers of health services in sustaining improvements in clinical practice is discussed.  (+info)

Agreeing criteria for audit of the management of induced abortion: an approach by national consensus survey. (6/2588)

OBJECTIVE: To obtain a national consensus view of suggested criteria for good quality care in induced abortion to serve as a basis for standards for audit to assess current clinical practice. DESIGN: Postal, questionnaire survey assessing consensus agreement with criteria identified from a literature review and refined by an invited panel of four gynaecologists and the gynaecology audit project in Scotland (GAPS) committee. SETTING: Scotland. SUBJECTS: All 132 practising consultant gynaecologists. MAIN MEASURES: Overall level of agreement with each of 20 suggested audit criteria. RESULTS: 121 completed questionnaires were received (response rate 92%), of which 119 were returned in time for analysis; 107 came from consultants who practised abortion routinely and were included in the analysis. Nineteen of 20 suggested criteria were validated by an overall balance of agreement. The most strongly supported criterion (agreement score +93) was for ascertaining rhesus status of the woman and prophylaxis after abortion, if indicated. The only criterion to elicit a negative agreement score (-27) was that dilatation and evacuation is the best method of abortion at 12-15 weeks' gestation. The ranked and prioritised criteria resulting from this exercise are being used within a national audit project. CONCLUSIONS: A postal questionnaire survey among interested clinicians resulted in a good response rate and enabled the audit criteria to be validated and ranked more objectively and among more clinicians, than would have been possible by group discussion.  (+info)

Audit of thrombolysis initiated in an accident and emergency department. (7/2588)

Early thrombolytic therapy after acute myocardial infarction is important in reducing mortality. To evaluate a system for reducing in-hospital delays to thrombolysis pain to needle and door to needle times to thrombolysis were audited in a major accident and emergency (A and E) department of a district general hospital and its coronary care unit (CCU), situated about 5 km away. Baseline performance over six months was assessed retrospectively from notes of 43 consecutive patients (group 1) transferred to the CCU before receiving thrombolysis. Subsequently, selected patients (23) were allowed to receive thrombolysis in the A and E department before transfer to the CCU. The agent was administered by medical staff in the department after receiving oral confirmation of myocardial infarction from the admitting medical officer in the CCU on receipt of fax transmission of the electrocardiogram. A second prospective audit during six months from the start of the new procedure established time intervals in 23 patients eligible to receive thrombolysis in the A and E department (group 2b) and 30 ineligible patients who received thrombolysis in the CCU (group 2a). The groups did not differ significantly in case mix, pre-hospital delay, or transfer time to the CCU. In group 2b door to needle time and pain to needle time were reduced significantly (geometric mean 38 min v 121 min (group 2a) and 128 min (group 1); 141 min v 237 min (group 2a) and 242 min (group 1) respectively, both p < 0.0001). The incidence of adverse effects was not significantly different. Nine deaths occurred (six in group 1, three in group 2b), an in-hospital mortality of 9.9%. Thrombolysis can be safely instituted in the A and E department in selected patients, significantly reducing delay to treatment.  (+info)

Improving quality through cost recovery in Niger. (8/2588)

New evidence on the quality of health care from public services in Niger is discussed in terms of the relationships between quality, costs, cost-effectiveness and financing. Although structural attributes of quality appeared to improve with the pilot project in Niger, significant gaps in the implementation of diagnostic and treatment protocols were observed, particularly in monitoring vital signs, diagnostic examination and provider-patient communications. Quality improvements required significant investments in both fixed and variable costs; however, many of these costs were basic input requirements for operation. It is likely that optimal cost-effectiveness of services was not achieved because of the noted deficiencies in quality. In the test district of Boboye, the revenues from the copayments alone covered about 34% of the costs of medicines or about 20% of costs of drugs and administration. In Say, user fees covered about 50-55% of the costs of medicines or 35-40% of the amount spent on medicines and cost-recovery administration. In Boboye, taxes plus the additional copayments covered 120-180% of the cost of medicines, or 75-105% of the cost of medicines plus administration of cost recovery. Decentralized management and legal conditions in the pilot districts appeared to provide the necessary structure to ensure that the revenues and taxes collected would be channelled to pay for quality improvements.  (+info)

Neoplasm refers to an abnormal growth of cells that can be benign (non-cancerous) or malignant (cancerous). Neoplasms can occur in any part of the body and can affect various organs and tissues. The term "neoplasm" is often used interchangeably with "tumor," but while all tumors are neoplasms, not all neoplasms are tumors.

Types of Neoplasms

There are many different types of neoplasms, including:

1. Carcinomas: These are malignant tumors that arise in the epithelial cells lining organs and glands. Examples include breast cancer, lung cancer, and colon cancer.
2. Sarcomas: These are malignant tumors that arise in connective tissue, such as bone, cartilage, and fat. Examples include osteosarcoma (bone cancer) and soft tissue sarcoma.
3. Lymphomas: These are cancers of the immune system, specifically affecting the lymph nodes and other lymphoid tissues. Examples include Hodgkin lymphoma and non-Hodgkin lymphoma.
4. Leukemias: These are cancers of the blood and bone marrow that affect the white blood cells. Examples include acute myeloid leukemia (AML) and chronic lymphocytic leukemia (CLL).
5. Melanomas: These are malignant tumors that arise in the pigment-producing cells called melanocytes. Examples include skin melanoma and eye melanoma.

Causes and Risk Factors of Neoplasms

The exact causes of neoplasms are not fully understood, but there are several known risk factors that can increase the likelihood of developing a neoplasm. These include:

1. Genetic predisposition: Some people may be born with genetic mutations that increase their risk of developing certain types of neoplasms.
2. Environmental factors: Exposure to certain environmental toxins, such as radiation and certain chemicals, can increase the risk of developing a neoplasm.
3. Infection: Some neoplasms are caused by viruses or bacteria. For example, human papillomavirus (HPV) is a common cause of cervical cancer.
4. Lifestyle factors: Factors such as smoking, excessive alcohol consumption, and a poor diet can increase the risk of developing certain types of neoplasms.
5. Family history: A person's risk of developing a neoplasm may be higher if they have a family history of the condition.

Signs and Symptoms of Neoplasms

The signs and symptoms of neoplasms can vary depending on the type of cancer and where it is located in the body. Some common signs and symptoms include:

1. Unusual lumps or swelling
2. Pain
3. Fatigue
4. Weight loss
5. Change in bowel or bladder habits
6. Unexplained bleeding
7. Coughing up blood
8. Hoarseness or a persistent cough
9. Changes in appetite or digestion
10. Skin changes, such as a new mole or a change in the size or color of an existing mole.

Diagnosis and Treatment of Neoplasms

The diagnosis of a neoplasm usually involves a combination of physical examination, imaging tests (such as X-rays, CT scans, or MRI scans), and biopsy. A biopsy involves removing a small sample of tissue from the suspected tumor and examining it under a microscope for cancer cells.

The treatment of neoplasms depends on the type, size, location, and stage of the cancer, as well as the patient's overall health. Some common treatments include:

1. Surgery: Removing the tumor and surrounding tissue can be an effective way to treat many types of cancer.
2. Chemotherapy: Using drugs to kill cancer cells can be effective for some types of cancer, especially if the cancer has spread to other parts of the body.
3. Radiation therapy: Using high-energy radiation to kill cancer cells can be effective for some types of cancer, especially if the cancer is located in a specific area of the body.
4. Immunotherapy: Boosting the body's immune system to fight cancer can be an effective treatment for some types of cancer.
5. Targeted therapy: Using drugs or other substances to target specific molecules on cancer cells can be an effective treatment for some types of cancer.

Prevention of Neoplasms

While it is not always possible to prevent neoplasms, there are several steps that can reduce the risk of developing cancer. These include:

1. Avoiding exposure to known carcinogens (such as tobacco smoke and radiation)
2. Maintaining a healthy diet and lifestyle
3. Getting regular exercise
4. Not smoking or using tobacco products
5. Limiting alcohol consumption
6. Getting vaccinated against certain viruses that are associated with cancer (such as human papillomavirus, or HPV)
7. Participating in screening programs for early detection of cancer (such as mammograms for breast cancer and colonoscopies for colon cancer)
8. Avoiding excessive exposure to sunlight and using protective measures such as sunscreen and hats to prevent skin cancer.

It's important to note that not all cancers can be prevented, and some may be caused by factors that are not yet understood or cannot be controlled. However, by taking these steps, individuals can reduce their risk of developing cancer and improve their overall health and well-being.

"Clinical packages & Protocols". katetchanturia.com. "Academy of Europe: Tchanturia Kate". www.ae-info.org. Retrieved 28 ... Pathway for Eating disorders and Autism developed from Clinical Experience). This clinical pathway was funded by The Health ... She has developed a novel clinical pathway for patients with comorbid autism and eating disorders at the South London and ... After relocating to London in 1997, she became a clinical research fellow at the Institute of Psychiatry, King's College London ...
In a clinical trial, the protocol is carefully designed to safeguard the health of the participants as well as answer specific ... While in a clinical trial, participants following a protocol are seen regularly by research staff to monitor their health and ... A good clinical protocol ensures that blinding is as effective as possible within ethical and practical constrains. During the ... In fact, such predefined protocols are an essential component of Good Laboratory Practice (GLP) and Good Clinical Practice (GCP ...
"Clinical protocol. Gene Therapy of Canavan Disease: AAV-2 Vector for Neurosurgical Delivery of Aspartoacylase Gene (ASPA) to ...
Limited clinical protocols for patient management. Limited technical operational manuals for program implementation. Health ...
Perlman, Sally E.; Nakajyma, Steven T.; Hertweck, S. Paige (2004). Clinical protocols in pediatric and adolescent gynecology. ... Perlman, Sally E.; Nakajyma, Steven T.; Hertweck, S. Paige (2004). Clinical protocols in pediatric and adolescent gynecology. ... Clinical and Pathological Aspects, Greenwich Medical Media: London, a)p.453, b)p.455 c)p.460. "Muslim women in France regain ...
Perlman, Sally E.; Nakajyma, Steven T.; Hertweck, S. Paige (2004). Clinical protocols in pediatric and adolescent gynecology. ... Clinical and Pathological Aspects, Greenwich Medical Media: London, a)p.453, b)p.455 c)p.460. The Marks of Childhood or the ... vaginal examinations for verifying a woman's virginity are a clinical practice which are at times state-enforced. These types ...
ISBN 978-0-7131-4452-9. Perlman SE, Nakajyma ST, Hertweck SP (2004). Clinical protocols in pediatric and adolescent gynecology ... Alldredge BK, Corelli RL, Ernst ME (2012). Koda-Kimble and Young's Applied Therapeutics: The Clinical Use of Drugs. Lippincott ... Sirven JI, Malamut BL (2008). Clinical Neurology of the Older Adult. Lippincott Williams & Wilkins. pp. 230-232. ISBN 978-0- ... Balon R, Segraves RT (2009). Clinical Manual of Sexual Disorders. American Psychiatric Pub. p. 258. ISBN 978-1-58562-905-3. ...
Perlman, Sally E.; Nakajyma, Steven T.; Hertweck, S. Paige (2004). Clinical protocols in pediatric and adolescent gynecology. ... Clinical and Pathological Aspects, Greenwich Medical Media: London, a)p.453, b)p.455 c)p.460. Heger, Astrid; Emans, S. Jean; ... Journal of Clinical Forensic Medicine. 13 (4): 172-180. doi:10.1016/j.jcfm.2006.02.006. ISSN 1353-1131. PMID 16564196. Hymen ...
... and the protocol has not been shown to be effective in clinical trials. Despite the lack of clinical efficacy, the protocol has ... Guaifenesin protocol is an unapproved treatment for fibromyalgia suggested in the 1990s by R. Paul St. Amand. The protocol ... He has recommended a follow-up study be conducted which controls for all elements of the protocol. The lead author of the study ... Amand, who participated as a "Study Advisor" to this clinical trial, has stated that the study did not control for salicylate ...
In 2006, an invited group of clinicians met in Chicago and reviewed clinical evidence and protocols, and adopted a new term for ... Large majorities of respondents opposed standard clinical protocols. A 2016 follow-up to the 2006 Consensus Statement, termed a ... a US professor of Clinical Medical Humanities and Bioethics, argues that little has changed in actual clinical practice in ... The committee stated: "clinical intervention pathways stated to be based on probabilities of cancer risk may be encapsulating ...
In 2006, an invited group of clinicians met in Chicago and reviewed clinical evidence and protocols, argued that and adopted a ... Large majorities of respondents opposed standard clinical protocols. A 2016 follow-up to the 2006 Consensus Statement, termed a ... There are no controlled clinical trials of the efficacy of early (less than 12 months of age) versus late surgery (in ... Clinical Pediatric and Adolescent Endocrinology.. Philadelphia: Saunders. An example of a now-obsolete recommendation to ...
"What stops hospital clinical staff from following protocols? An analysis of the incidence and factors behind the failure of ... These tools can predict clinical deterioration based upon the patient's trait (e.g. has epilepsy) and detect deterioration ... UK National Institute for Health and Clinical Excellence (NICE) (July 2007). "Acutely ill patients in hospital: recognition of ... A RRS consists of two clinical components (afferent and efferent) and two organizational components (process improvement and ...
Clinical Applications of Capillary Electrophoresis: Methods and Protocols. Methods in Molecular Biology. Vol. 1972. New York, ...
Clinical Toxinology Resources. Snakebite Protocols - Oxyuranus microlepidotus. "Signs and Symptoms of Envenomation: E. Fang ... Clinical Toxinology Resources. Snakebite Protocols - Oxyuranus microlepidotus. "Signs and Symptoms of Envenomation: E. Fang ... Clinical Toxinology Resources. Snakebite Protocols - Oxyuranus microlepidotus. University of Adelaide. Retrieved 18 October ... Clinical Toxinology Resources. "Oxyuranus microlepidotus -General Details, Taxonomy and Biology, Venom, Clinical Effects, ...
"Effects of a supportive protocol processing system (ProtoVIEW) on clinical behaviour of residents in the Accident and Emergency ... Examples of active protocol systems include trigger-automated order entry systems and appointment scheduling. Active protocol ... Studies have shown that protocols can aid in optimising patient care. There are two types of protocol systems: passive and ... A computer-based protocol system is a paradigm providing a set of tools which allow health care providers access to current ...
ISBN 978-94-009-8195-9. Lt Col Pankaj Talwar; Surveen Ghumann Sindhu (18 May 2012). Step by Step: Protocols in Clinical ...
Clinical trial protocols are the centerpiece of the IND. Detailed protocols for proposed clinical studies to assess whether the ... If the FDA detects a problem, it may place a clinical hold on the IND, prohibiting the start of the clinical studies until the ... Once an IND is submitted, the FDA has 30 days to object to the IND or it automatically becomes effective and clinical trials ... About half of the INDs fail in preclinical and clinical phases of drug development. The FDA runs a medical marijuana IND ...
Wyatt, Richard Jed; Chew, Robert H. (2008). Wyatt's Practical Psychiatric Practice: Forms and Protocols for Clinical Use. ... Shin, Jin; Park, Doo-Heum; Ryu, Seung-Ho; Ha, Jee Hyun; Kim, Seol Min; Jeon, Hong Jun (2020-07-24). "Clinical implications of ... The disappearance of residual and sub-clinical agoraphobic avoidance, and not simply of panic attacks, should be the aim of ... In the social sciences, a perceived clinical bias exists in agoraphobia research. Branches of the social sciences, especially ...
Forms and Protocols for Clinical Use. American Psychiatric Pub. pp. 142-. ISBN 978-1-58562-687-8. Katherine M. Fortinash; ... Larsson M, Axelsson R, Forsman A (1984). "On the pharmacokinetics of perphenazine: a clinical study of perphenazine enanthate ... Abstract.). 19th Annual Midyear Clinical Meeting of the American Society of Hospital Pharmacists. Dallas, Texas. Janssen PA, ... The Journal of Clinical Psychiatry. 45 (5 Pt 2): 50-9. PMID 6143748. Curry SH, Whelpton R, de Schepper PJ, Vranckx S, Schiff AA ...
Kellams A, Harrel C, Omage S, Gregory C, Rosen-Carole C (May 2017). "ABM Clinical Protocol #3: Supplementary Feedings in the ... Eglash A, Simon L (September 2017). "ABM Clinical Protocol #8: Human Milk Storage Information for Home Use for Full-Term ... Boies EG, Vaucher YE (December 2016). "ABM Clinical Protocol #10: Breastfeeding the Late Preterm (34-36 6/7 Weeks of Gestation ... Boies EG, Vaucher YE (December 2016). "ABM Clinical Protocol #10: Breastfeeding the Late Preterm (34-36 6/7 Weeks of Gestation ...
MOMENTUM 3 IDE Clinical Study Protocol (HM3). U.S. National Institutes of Health. ClinicalTrials.gov. Retrieved September 16, ... is still in clinical trials for destination therapy. In a two-year randomized controlled clinical trial published in 2009 ... It began undergoing clinical trials in the U.S. and internationally in mid 2014. In mid 2014, CE Mark trials also started for ... It is cleared for clinical use up to six hours, and can be used as a short-term solution to support the circulation while ...
AIDS Clinical Trials Protocol 5015 Team (2010). "Age-Related Changes in Plasma Concentrations of the HIV Protease Inhibitor ... In the following year, he served as a Clinical Fellow in Infectious Diseases and Clinical Pharmacology at the Johns Hopkins ... results of AIDS Clinical Trials Group (ACTG) A5073, a 48-week randomized controlled trial. Clinical Infectious Diseases, 50, ... American Society for Clinical Pharmacology and Therapeutics 1995 - Pfizer Visiting Professor of Medicine and Clinical ...
Spinifex Pharmaceuticals Pty Limited (2011). "CLINICAL STUDY PROTOCOL: Protocol No. EMA401-003". {{cite journal}}: Cite journal ... Spinifex Pharmaceuticals Pty Limited (2011). "CLINICAL STUDY PROTOCOL: Protocol No. EMA401-003". {{cite journal}}: Cite journal ... Spinifex Pharmaceuticals Pty Limited (2011). "CLINICAL STUDY PROTOCOL: Protocol No. EMA401-003". {{cite journal}}: Cite journal ... Phase I clinical trial have indicated that doses of EMA401 up to 400 mg are safe in humans. Spinifex Pharmaceuticals reported ...
"Clinical Study Protocol mRNA-1273-P301" (PDF). Moderna. 20 August 2020. Archived from the original (PDF) on 17 September 2020. ... The clinical trial is ongoing and is set to conclude in late 2022. Pregnant and breastfeeding women were also excluded from the ... A review by the FDA in December 2020, of interim results of the phase III clinical trial on mRNA-1273 showed it to be safe and ... The vaccine in low doses was deemed safe and effective in order to advance a phase III clinical trial using two 100-μg doses ...
"ABM Clinical Protocol #26: Persistent Pain with Breastfeeding". Breastfeeding Medicine. 11 (2): 46-53. doi:10.1089/bfm. ... Kulkarni, Dhananjay (2020). "Clinical Presentations of Breast Disorders in Pregnancy and Lactation". Advances in Experimental ... Berens, Pamela D. (December 2015). "Breast Pain: Engorgement, Nipple Pain, and Mastitis". Clinical Obstetrics & Gynecology. 58 ... "Practice-based interpretation of ultrasound studies leads the way to more effective clinical support and less pharmaceutical ...
Clinical protocol, a method in a clinical trial or medical research study This disambiguation page lists articles associated ... Medical protocol may refer to: Medical guideline, for a medical treatment Medical protocol, a set of rules followed by an ... with the title Medical protocol. If an internal link led you here, you may wish to change the link to point directly to the ...
The clinical protocol began on May 22, 1989, and included 10 patients. The procedure was shown to be safe. Rosenberg went on to ... Only after approval by that formal public governmental review did the gene therapy clinical protocol move on for review by the ... Microinjecting a few non-stem cells was clearly not an efficient procedure for a clinical protocol. In 1984, Anderson published ... Anderson, together with bioethicist John Fletcher, set the ethical standard for this type of clinical protocol in his 1980 ...
He improved and standardized clinical protocols for conducting Laryngeal electromyography in patients. He established clinical ... Later he moved to Norway, where he did a specialization degree in clinical neurophysiology at Oslo University in 1970. He then ... Kotby, M. Nasser (2018-12-28). "Egypt: Four Decades of Voice Research and Clinical Application". The ASHA Leader. 11 (7): 30-32 ... Kotby, M. N. (March 1969). "Electromyography of the laryngeal muscles". Electroencephalography and Clinical Neurophysiology. 26 ...
Bagatto, M; Moodie, S; Scollie, S; Seewald, R; Moodie, S; Pumford, J; Liu, KP (2005). "Clinical protocols for hearing ... As with most clinical tests, standardized calibration of the test environment, the equipment and the stimuli is needed before ... Although pure-tone audiometry has many clinical benefits, it is not perfect at identifying all losses, such as 'dead regions' ... Handbook of clinical audiology. Katz, Jack., Burkard, Robert, 1953-, Medwetsky, Larry. (5th ed.). Philadelphia: Lippincott ...
Typical stimulation protocols used in clinical FES involves trains of electric pulses. Biphasic, charged balanced pulses are ... Initial Phase II clinical trials conducted with FEST for reaching and grasping, and walking were carried out at KITE, the ... Taylor PN, Burridge JH, Dunkerley AL, Wood DE, Norton JA, Singleton C, Swain ID (1999). "Clinical use of the Odstock dropped ... clinical case reports". Archives of Physical Medicine and Rehabilitation. 77 (11): 1119-1128. doi:10.1016/s0003-9993(96)90133-1 ...
American Society of Clinical Oncology Resource-Stratified Clinical Practice Guideline". Journal of Global Oncology. 2 (5): 311- ... Cochrane Gynaecological, Neuro-oncology and Orphan Cancer Group) (November 2013). "Follow-up protocols for women with cervical ... The Pap test was integrated into clinical practice in the Nordic countries in the 1960s. In Africa outcomes are often worse as ... Chicago, IL: American Society for Clinical Pathology Press. ISBN 978-0-89189-549-7. Garcia A, Hamid O, El-Khoueiry A (6 July ...
"Norovirus , Clinical Overview , CDC". www.cdc.gov. Archived from the original on 2016-03-17. Retrieved 2016-03-28. Bok, K. and ... Routine protocols to detect norovirus in clams and oysters by reverse transcription polymerase chain reaction are being ... In 2011, the CDC published a clinical practice guideline addressing strategies for the prevention and control of norovirus ... Journal of Clinical Microbiology. 48 (3): 915-920. doi:10.1128/JCM.01664-09. PMC 2832421. PMID 20053852. Carlsson B, Kindberg E ...
Clinical Infectious Diseases. 61 (7): 1035-1042. doi:10.1093/cid/civ453. ISSN 1058-4838. PMID 26060289. Goeijenbier M, van ... criticism was levelled at current screening protocols at UK points of entry, which mainly consisted of taking a person's ...
She was the Protocol Chair of the first SA microbicide network trial (FACTS 001), a Phase 3 trial of 1% tenofovir gel for HIV ... Rees is an Honorary Professor in the Department of Clinical Research at the London School of Hygiene and Tropical Medicine. ...
In human clinical trials of the company's HIV vaccines, GeoVax demonstrated that VLPs are safe and eliciting both strong and ... As part of the trial protocol, a volunteer must have begun drug treatment in the first year of infection and have achieved 6 ... "Encouraged By Early Clinical Studies, A Biotech Company Expands Its HIV/AIDS Vaccine Program." Medical News Today. April 12, ... GeoVax is a clinical-stage biotechnology company initially established primarily to develop an effective and safe vaccine ...
He is also credited with the isolation of Hepatitis E virus and the introduction of a new therapeutic protocol of the Hepatitis ... Journal of Clinical Gastroenterology and Gastroenterology International counting among them. Tandon is a Fellow of the National ... clinical, and virological characteristics of hepatocellular carcinoma in Asia: Survey of 414 patients from four countries". ...
However he also maintains a clinical practice and continuing research. In 2020 he was elected Vice-Chair of the Board of ... ISBN 0-7020-2559-3 Steven D. Wexner, (1999). Protocols in General Surgery: Laparoscopic Colorectal Surgery. ISBN 0471240303 As ... S.R. Steele, J.A. Maykel, S.D. Wexner (Eds.), (2020). Clinical Decision Making in Colorectal Surgery, 2nd ed. Springer Nature ... Wexner holds academic appointments as Affiliate Professor at Florida Atlantic University; Clinical Professor at Florida ...
The Pediatric Oncology Group (POG) was a U.S. and Canadian clinical trial cooperative group created with the mission of ... The Pediatric Oncology Group has all of its protocol-driven cases reviewed at the Quality Assurance Review Center (QARC). As ... Clinical trial organizations, Children's Oncology Group, All stub articles, Pediatrics stubs, Oncology stubs). ...
The prevalence of fear of childbirth around the world ranges between 4-25%, with 3-7% of pregnant women having clinical fear of ... protocols and behaviors. The Baby-Friendly Hospital Initiative includes a very rigorous credentialing process that includes a ... Clinical Obstetrics & Gynaecology. 22 (6): 1103-17. doi:10.1016/j.bpobgyn.2008.07.005. PMID 18793876. Ball H (June 2009). " ... Martin C (2012). Perinatal Mental Health: a Clinical Guide. Cumbria England: M & K Pub. p. 26. ISBN 978-1907830495. Alder J, ...
Biology and biochemistry Chemistry Clinical medicine Engineering Environment and ecology Geosciences Materials science ... Research Center in Seattle under a cooperative research and development agreement to develop safe and effective protocols for ...
His main clinical expertise is in treatment of obsessive-compulsive disorder, body dysmorphic disorder (BDD), emetophobia and ... He has developed and evaluated protocols for BDD and emetophobia that are used by other cognitive behaviour therapists (CBT). ... He has conducted a range of clinical research, especially in body dysmorphic disorder, obsessive-compulsive disorder, ...
The Protocol Amending the Agreements, Conventions and Protocols on Narcotic Drugs concluded at The Hague on 23 January 1912, at ... including clinical trials therewith to be conducted under or subject to the direct supervision and control of the Party. The ... The 1953 New York Opium Protocol, which had not yet entered into force, limited opium production to seven countries; the Single ... The conference met at the United Nations Office at Geneva from 6 to 24 March 1972, producing the 1972 Protocol Amending the ...
"Interim Clinical Guidance for the Treatment of Monkeypox , Monkeypox , Poxvirus , CDC". U.S. Centers for Disease Control and ... The Ministry of Health has put in place infection prevention protocols at the border. Minister for Health Ifereimi Waqainabete ... 24 May 2022). "Clinical features and management of human monkeypox: a retrospective observational study in the UK". The Lancet ... Monkeypox infection was immediately suspected, and the patient was hospitalised at a specialist clinical unit of the Guy's and ...
She leads efforts to advance the impact of HCI's research in laboratory, clinical and population science, with the goal of ... Ulrich is also Principal Investigator of the HCI Total Cancer Care Protocol in the ORIEN network of cancer centers. Ulrich ...
Clinical Cancer Research 24(15) 3539-3549.PMID 29691297 Zill OA et al. (2018) The Landscape of Actionable Genomic Alterations ... US 8236532, Ronaghi, Mostafa & Eltoukhy, Helmy, "Multibase delivery for long reads in sequencing by synthesis protocols", ... 2015) Analytical and Clinical Validation of a Digital Sequencing Panel for Quantitative, Highly Accurate Evaluation of Cell- ... Clinical Cancer Research 24(15), 3528-3538 PMID 29776953 Engineered luciferases, (2009). Biological analysis arrangement and ...
... derives its name from the cluster of differentiation protocol that identifies cell surface antigens. CD34 was first ... Antibodies are used to quantify and purify hematopoietic progenitor stem cells for research and for clinical bone marrow ... Due to these historical and clinical associations, CD34 expression is almost ubiquitously related to hematopoietic cells; ...
Abolhassan Zia-Zarifi and his colleagues set about adapting these protocols for use with limited resources. As a result, he ... Clinical Study of Tuberculosis (with Velayati, Masjedi, Tabatabaii) (1995) Nobel Prize Winners in Physiology or Medicine (now ... Poverty and logistical difficulties often prevented rural laboratories from following strict international protocols. ...
For services to the NHS Haluk Metin Çekirdek - Protocol and Customs Officer, British Embassy, Ankara. For services to the ... Onyinye Aureola Enwezor - Shared Governance Clinical Educator, Nottingham University Hospitals NHS Trust. For services to the ...
Process enrolled 1,341 patients, of whom 439 were randomly assigned to protocol-based EGDT (Rivers EGDT), 446 to protocol-based ... ARISE Investigators; ANZICS Clinical Trials Group (2014). "Goal-directed resuscitation for patients with early septic shock". ... Many hospitals across the United States such as Kaiser and Catholic Health Care West have rapidly incorporated the protocol ... published in the New England Journal of Medicine compared EGDT versus other protocol-directed care versus standard care. There ...
Clinical trials should comply with all the standards and protocols under the Directorate General of Health Services. Right to ... The Clinical Establishments (Registration and Regulation) ACT, 2010 (2018). "Charter of Patients' Rights for adoption by NHRC ... Following a recommendation by the National Council of Clinical Establishments, MOHFW submitted the draft in the public domain ... Right to protection for patients involved in clinical trials: ... the Clinical Establishment Act of 2010, and various judgments ...
He has also published on clinical aspects of Alzheimer's disease and other causes of cognitive impairment. In recent years Dr. ... www.cingulate.ibms.sinica.edu.tw/Ftpshare/Protocol/Internet%20Resources/E%20books/glucose%20metabolism%20in%20the%20brain/8.pdf ... He established and directed the Dementia Research Service, a combined research and clinical unit at a Cornell affiliated ... He belongs to a number of other scholarly societies, including the American Society for Clinical Investigation, the American ...
... screening of newborns and children in the field of predictive medicine is deemed appropriate if there is a compelling clinical ... testing ranges from common consulting room tests such as measuring blood pressure and urine tests to more invasive protocols ...
... but some dance schools have integrated it into a standard somatics protocol for all dancers because it is thought to optimize ... current research as a guide to clinical practice" (PDF), Alternative & Complementary Therapies, 10 (2): 84-89, doi:10.1089/ ...
Clinical laboratory findings of elevated IL‑2, IL‑7, IL‑6, granulocyte-macrophage colony-stimulating factor (GM‑CSF), ... The WHO has published several testing protocols for the disease. Several laboratories and companies have developed serological ... In addition to the above, other clinical studies have proved that SARS-CoV-2 can affect the period of pregnancy in different ... A cytokine storm is due to an acute hyperinflammatory response that is responsible for clinical illness in an array of diseases ...
In 2005 she was awarded a Senior Research Fellowship which allowed her to evaluate tuberculosis screening protocols. Corbett ... and Lung Disease 2004 Awarded the Chalmers Medal by the Royal Society of Tropical Medicine and Hygiene 2007 Clinical Excellence ...
"Behavioral Core Protocols and Training: Marble Burying" (PDF). Biobserve. Albert Einstein College of Medicine. Archived from ... Clinical Psychology Review. 45: 115-130. doi:10.1016/j.cpr.2015.10.005. PMID 26953005. Borsini, Franco; Podhorna, Jana; ... Protocol. 1 (1): 122-124. doi:10.1038/nprot.2006.20. PMID 17406223. S2CID 205463476. Albelda, Noa; Joel, Daphna (2012). "Animal ...
Other researchers emphasize that better developed protocols and procedures for patient discharge are one of the most important ... Clinical Medicine. 12 (4): 320-323. doi:10.7861/clinmedicine.12-4-320. ISSN 1470-2118. PMC 4952118. PMID 22930874. Kantarevic, ... Researchers also interviewed doctors who reported that EMTALA citation fines were a disincentive to violate EMTALA protocols. ... and in the years after its passage hospitals struggled with creating appropriate discharge protocols and the cost of providing ...
Correa-Pérez is involved in the development, implementation and oversight of research protocols in which the use of animals is ... Embryology Juan R. Correa-Pérez is a scientist who is credited with becoming the first clinical Andrologist and Embryologist in ... In 1953, he earned his doctorate degree (PhD) in Clinical Psychology from Purdue University, located in West Lafayette, Indiana ... psychological and cultural aspects in addition to considering immunological and clinical procedure. The book now is in its ...
Disadvantages of MRI include lengthy protocols and the potential for claustrophobia. Furthermore, an MRI scan cannot be ... Most uses are for research, not clinical purposes. Appropriate radioisotopes of elements within chemical compounds of the ... depending on the equipment and protocol used). These images are reconstructed using algorithms and software. Great development ... cardiac MRI is projected to increase through greater availability of scanners and more widespread knowledge about its clinical ...
... particularly those that use protocols such as Modbus, Bluetooth, Zigbee, or proprietary protocols, to connect to an Edge ... As of 2018[update] IoMT was not only being applied in the clinical laboratory industry, but also in the healthcare and health ... IETF's Constrained Application Protocol, ZeroMQ, and MQTT can provide lightweight data transport. In practice many groups of ... ZigBee - Communication protocols for personal area networking based on the IEEE 802.15.4 standard, providing low power ...

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