Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis.
Breaks in bones.
The amount of mineral per square centimeter of BONE. This is the definition used in clinical practice. Actual bone density would be expressed in grams per milliliter. It is most frequently measured by X-RAY ABSORPTIOMETRY or TOMOGRAPHY, X RAY COMPUTED. Bone density is an important predictor for OSTEOPOROSIS.
Breaks in bones resulting from low bone mass and microarchitectural deterioration characteristic of OSTEOPOROSIS.
The specialty of ANALYTIC CHEMISTRY applied to assays of physiologically important substances found in blood, urine, tissues, and other biological fluids for the purpose of aiding the physician in making a diagnosis or following therapy.
The continuous turnover of BONE MATRIX and mineral that involves first an increase in BONE RESORPTION (osteoclastic activity) and later, reactive BONE FORMATION (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium HOMEOSTASIS. An imbalance in the regulation of bone remodeling's two contrasting events, bone resorption and bone formation, results in many of the metabolic bone diseases, such as OSTEOPOROSIS.
Metabolic disorder associated with fractures of the femoral neck, vertebrae, and distal forearm. It occurs commonly in women within 15-20 years after menopause, and is caused by factors associated with menopause including estrogen deficiency.
An abrupt voluntary shift in ocular fixation from one point to another, as occurs in reading.
Area of the OCCIPITAL LOBE concerned with the processing of visual information relayed via VISUAL PATHWAYS.
The first digit on the radial side of the hand which in humans lies opposite the other four.
Area of the FRONTAL LOBE concerned with primary motor control located in the dorsal PRECENTRAL GYRUS immediately anterior to the central sulcus. It is comprised of three areas: the primary motor cortex located on the anterior paracentral lobule on the medial surface of the brain; the premotor cortex located anterior to the primary motor cortex; and the supplementary motor area located on the midline surface of the hemisphere anterior to the primary motor cortex.
Voluntary or reflex-controlled movements of the eye.
Investigative technique commonly used during ELECTROENCEPHALOGRAPHY in which a series of bright light flashes or visual patterns are used to elicit brain activity.
Imaging techniques used to colocalize sites of brain functions or physiological activity with brain structures.
Thiohydantoin benzene derivative.
An enzyme that catalyzes the hydrolysis of CHOLESTEROL ESTERS and some other sterol esters, to liberate cholesterol plus a fatty acid anion.
A formal process of examination of patient care or research proposals for conformity with ethical standards. The review is usually conducted by an organized clinical or research ethics committee (CLINICAL ETHICS COMMITTEES or RESEARCH ETHICS COMMITTEES), sometimes by a subset of such a committee, an ad hoc group, or an individual ethicist (ETHICISTS).
That segment of commercial enterprise devoted to the design, development, and manufacture of chemical products for use in the diagnosis and treatment of disease, disability, or other dysfunction, or to improve function.
Hospital or other institutional committees established to protect the welfare of research subjects. Federal regulations (the "Common Rule" (45 CFR 46)) mandate the use of these committees to monitor federally-funded biomedical and behavioral research involving human subjects.
Diminution or cessation of secretion of one or more hormones from the anterior pituitary gland (including LH; FOLLICLE STIMULATING HORMONE; SOMATOTROPIN; and CORTICOTROPIN). This may result from surgical or radiation ablation, non-secretory PITUITARY NEOPLASMS, metastatic tumors, infarction, PITUITARY APOPLEXY, infiltrative or granulomatous processes, and other conditions.
Unsaturated androstanes which are substituted with one or more hydroxyl groups in any position in the ring system.
Publications printed and distributed daily, weekly, or at some other regular and usually short interval, containing news, articles of opinion (as editorials and letters), features, advertising, and announcements of current interest. (Webster's 3d ed)
Agents that inhibit BONE RESORPTION and/or favor BONE MINERALIZATION and BONE REGENERATION. They are used to heal BONE FRACTURES and to treat METABOLIC BONE DISEASES such as OSTEOPOROSIS.
Instruments or technological means of communication that reach large numbers of people with a common message: press, radio, television, etc.

A multicomponent intervention to prevent delirium in hospitalized older patients. (1/2588)

BACKGROUND: Since in hospitalized older patients delirium is associated with poor outcomes, we evaluated the effectiveness of a multicomponent strategy for the prevention of delirium. METHODS: We studied 852 patients 70 years of age or older who had been admitted to the general-medicine service at a teaching hospital. Patients from one intervention unit and two usual-care units were enrolled by means of a prospective matching strategy. The intervention consisted of standardized protocols for the management of six risk factors for delirium: cognitive impairment, sleep deprivation, immobility, visual impairment, hearing impairment, and dehydration. Delirium, the primary outcome, was assessed daily until discharge. RESULTS: Delirium developed in 9.9 percent of the intervention group as compared with 15.0 percent of the usual-care group, (matched odds ratio, 0.60; 95 percent confidence interval, 0.39 to 0.92). The total number of days with delirium (105 vs. 161, P=0.02) and the total number of episodes (62 vs. 90, P=0.03) were significantly lower in the intervention group. However, the severity of delirium and recurrence rates were not significantly different. The overall rate of adherence to the intervention was 87 percent, and the total number of targeted risk factors per patient was significantly reduced. Intervention was associated with significant improvement in the degree of cognitive impairment among patients with cognitive impairment at admission and a reduction in the rate of use of sleep medications among all patients. Among the other risk factors per patient there were trends toward improvement in immobility, visual impairment, and hearing impairment. CONCLUSIONS: The risk-factor intervention strategy that we studied resulted in significant reductions in the number and duration of episodes of delirium in hospitalized older patients. The intervention had no significant effect on the severity of delirium or on recurrence rates; this finding suggests that primary prevention of delirium is probably the most effective treatment strategy.  (+info)

Can we cure indolent lymphomas? (2/2588)

The current consensus is that indolent lymphomas are incurable disorders. There are some indications that these malignancies are potentially curable. Indeed, not all indolent lymphomas are currently incurable. For example, patients with Ann Arbor stage I-II indolent lymphomas can experience long-term disease-free survival and probable cure. Also, from the available literature data, it seems that the achievement of a molecular complete remission is a desirable objective. Patients who achieve a persistently negative PCR state seldom relapse, whereas the opposite is true for persistently positive cases. In view of its excellent correlation with disease-free survival when examined serially in multiple blood or marrow samples, the PCR technique has the potential of providing a tumor marker that can be used as an early end point for clinical trials. By serving as an early surrogate end point, PCR could play an important role in expediting the development of new treatment strategies. Whether IFN is capable of increasing the molecular complete remission rate as measured by PCR is not known. However, it is clear that from the clinical standpoint, IFN has been able to increase 2-fold the length of remission in patients with advanced indolent lymphomas. In at least two studies, this has been associated with prolongation of survival. More intensive regimens such as alternating triple therapy, when used in combination with IFN, seem to have improved the quality of remissions as judged by the PCR assay. Finally, the site where the bcl-2 breakpoint occurs seems to have clinical significance. Those follicular lymphomas with germ-line bcl-2, in our experience, have behaved more aggressively than the others, and their failure-free survival seems different from the usual indolent lymphomas and more closely resembles the large cell lymphomas. Although the biological significance of this observation is not yet understood, this group might actually constitute a prognostically different subset with a more aggressive and perhaps more curable lymphoma. Whether the plateau observed in their failure-free survival curve will be maintained with more follow-up and whether they might be a curable subset remain to be determined.  (+info)

Low-molecular-weight heparin in outpatient treatment of DVT. (3/2588)

Patients with a diagnosis of acute deep venous thrombosis have traditionally been hospitalized and treated with unfractionated heparin followed by oral anticoagulation therapy. Several clinical trials have shown that low-molecular-weight heparin is at least as safe and effective as unfractionated heparin in the treatment of uncomplicated deep venous thrombosis. The use of low-molecular-weight heparin in an outpatient program for the management of deep venous thrombosis provides a treatment alternative to hospitalization in selected patients. Use of low-molecular-weight heparin on an outpatient basis requires coordination of care, laboratory monitoring, and patient education and participation in treatment. Overlapping the initiation of warfarin permits long-term anticoagulation. Advantages include a decreased incidence of heparin-induced thrombocytopenia and fewer episodes of bleeding complications. Future clinical trials evaluating the safety and efficacy of low-molecular-weight heparin in the treatment of complicated deep venous thrombosis will further define appropriate indications for use and strategies for outpatient management.  (+info)

Time course of respiratory decompensation in chronic obstructive pulmonary disease: a prospective, double-blind study of peak flow changes prior to emergency department visits. (4/2588)

The aim of this study was to look at changes in peak expiratory flow rates (PEFR) prior to emergency department visits for decompensated chronic obstructive pulmonary disease (COPD). It was designed as a prospective, double-blind study at the Albuquerque Veterans Affairs Medical Center. Twelve patients with an irreversible component of airflow obstruction on pulmonary function tests were assessed. At entry, all subjects were instructed in the use of a mini-Wright peak flow meter with electronic data storage. They then entered a 6-month monitoring phase in which they recorded PEFR twice daily, before and after bronchodilators. The meter displays were disabled so that the patients and their physicians were blinded to all values. Medical care was provided in the customary manner. Patients were considered to have respiratory decompensation if they required treatment for airflow obstruction in the Emergency Department (ED) and no other causes of dyspnea could be identified. Simple linear regression was used to model changes in PEFR over time. The 12 subjects had 22 episodes of respiratory decompensation during 1741 patient-days of observation. Two episodes could not be analysed because of missing values. Ten episodes in seven subjects were characterized by a significant linear decline in at least one peak flow parameter prior to presentation. The mean rates of change for the four daily parameters varied from 0.22% to 0.27% predicted per day (or 1.19 to 1.44 1 min-1 day-1). The average decrement in these parameters ranged from 30.0 to 33.8 1 min-1 (or 18.6%-25.9% of their baseline values). No temporal trends were found for the 10 episodes occurring in the other five subjects. We concluded that respiratory decompensation is characterized by a gradual decline in PEFR in about half of cases. Future studies should be done to elucidate the mechanisms of respiratory distress in the other cases.  (+info)

Enhancing the identification of excessive drinkers on medical wards: a 1-year follow-up study. (5/2588)

This paper describes a 1-year follow-up study examining whether hospital ward doctors and nurses continue to take quantitative alcohol histories and provide brief intervention to problem drinkers on general medical wards after the introduction of a simple protocol. Regular training in the use of this protocol was stipulated in the annual service contract between the Health Authority and the Hospital Trusts. Improvements in staff practice persisted at 1-year follow-up, although it fell from a peak at an earlier phase of the study. The positive role of state purchasers of health services in sustaining improvements in clinical practice is discussed.  (+info)

Agreeing criteria for audit of the management of induced abortion: an approach by national consensus survey. (6/2588)

OBJECTIVE: To obtain a national consensus view of suggested criteria for good quality care in induced abortion to serve as a basis for standards for audit to assess current clinical practice. DESIGN: Postal, questionnaire survey assessing consensus agreement with criteria identified from a literature review and refined by an invited panel of four gynaecologists and the gynaecology audit project in Scotland (GAPS) committee. SETTING: Scotland. SUBJECTS: All 132 practising consultant gynaecologists. MAIN MEASURES: Overall level of agreement with each of 20 suggested audit criteria. RESULTS: 121 completed questionnaires were received (response rate 92%), of which 119 were returned in time for analysis; 107 came from consultants who practised abortion routinely and were included in the analysis. Nineteen of 20 suggested criteria were validated by an overall balance of agreement. The most strongly supported criterion (agreement score +93) was for ascertaining rhesus status of the woman and prophylaxis after abortion, if indicated. The only criterion to elicit a negative agreement score (-27) was that dilatation and evacuation is the best method of abortion at 12-15 weeks' gestation. The ranked and prioritised criteria resulting from this exercise are being used within a national audit project. CONCLUSIONS: A postal questionnaire survey among interested clinicians resulted in a good response rate and enabled the audit criteria to be validated and ranked more objectively and among more clinicians, than would have been possible by group discussion.  (+info)

Audit of thrombolysis initiated in an accident and emergency department. (7/2588)

Early thrombolytic therapy after acute myocardial infarction is important in reducing mortality. To evaluate a system for reducing in-hospital delays to thrombolysis pain to needle and door to needle times to thrombolysis were audited in a major accident and emergency (A and E) department of a district general hospital and its coronary care unit (CCU), situated about 5 km away. Baseline performance over six months was assessed retrospectively from notes of 43 consecutive patients (group 1) transferred to the CCU before receiving thrombolysis. Subsequently, selected patients (23) were allowed to receive thrombolysis in the A and E department before transfer to the CCU. The agent was administered by medical staff in the department after receiving oral confirmation of myocardial infarction from the admitting medical officer in the CCU on receipt of fax transmission of the electrocardiogram. A second prospective audit during six months from the start of the new procedure established time intervals in 23 patients eligible to receive thrombolysis in the A and E department (group 2b) and 30 ineligible patients who received thrombolysis in the CCU (group 2a). The groups did not differ significantly in case mix, pre-hospital delay, or transfer time to the CCU. In group 2b door to needle time and pain to needle time were reduced significantly (geometric mean 38 min v 121 min (group 2a) and 128 min (group 1); 141 min v 237 min (group 2a) and 242 min (group 1) respectively, both p < 0.0001). The incidence of adverse effects was not significantly different. Nine deaths occurred (six in group 1, three in group 2b), an in-hospital mortality of 9.9%. Thrombolysis can be safely instituted in the A and E department in selected patients, significantly reducing delay to treatment.  (+info)

Improving quality through cost recovery in Niger. (8/2588)

New evidence on the quality of health care from public services in Niger is discussed in terms of the relationships between quality, costs, cost-effectiveness and financing. Although structural attributes of quality appeared to improve with the pilot project in Niger, significant gaps in the implementation of diagnostic and treatment protocols were observed, particularly in monitoring vital signs, diagnostic examination and provider-patient communications. Quality improvements required significant investments in both fixed and variable costs; however, many of these costs were basic input requirements for operation. It is likely that optimal cost-effectiveness of services was not achieved because of the noted deficiencies in quality. In the test district of Boboye, the revenues from the copayments alone covered about 34% of the costs of medicines or about 20% of costs of drugs and administration. In Say, user fees covered about 50-55% of the costs of medicines or 35-40% of the amount spent on medicines and cost-recovery administration. In Boboye, taxes plus the additional copayments covered 120-180% of the cost of medicines, or 75-105% of the cost of medicines plus administration of cost recovery. Decentralized management and legal conditions in the pilot districts appeared to provide the necessary structure to ensure that the revenues and taxes collected would be channelled to pay for quality improvements.  (+info)

0113] Although it is shown by way of example that a browser program (e.g. 1215) may be used to access a protocol builder system by users to perform functions for developing drug protocols, it should be appreciated that other program types may be used to interface a user to server process 1213 or a protocol builder system. For instance, an application program 1214 that is specially-developed to manage drug protocol development may be provided to permit a user to participate in a project, answer challenge questions, etc., according to various embodiments of the present invention. A client program may be, for example, a thin client including an interface for submitting and monitoring challenge questions, and/or drug protocol development projects. Alternatively, the client may be a scripted program, or any other type of program having the capability of transferring data. According to one embodiment, such client programs may, for example, be downloaded and installed over the network. Further, these ...
Given a potentially huge set of candidate criteria, our goal is to help users choose the most appropriate criteria from among the candidates. In this work, we assume that the candidate criteria exist in some document(s) in a given repository, either separately from different documents or together in the same document, and our technical objective is to rank these candidates according to their appropriateness to the task at hand. As mentioned previously, such task would be to put together a clinical trial protocol about some particular disease, treatment, or drug.. To provide a concrete idea of our problem, the following is a snippet of a clinical trial protocol, downloaded from the clinical trials website http://www.clinicaltrials.gov, and modified for presentation as an example. It shows the title, the objective of the clinical trial as well as the inclusion and exclusion criteria.. Title: Antioxidant Systems and Age-Related Macular Degeneration Objective:. The objective of this study is to ...
By (author): John E. Turrentine. Expanded and updated, the new edition of the bestselling Clinical Protocols in Obstetrics and Gynecology is the definitive quick-reference for use in office practice and hospital settings. With information drawn from ACOG technical bulletins, OB/GYN publications, articles, textbooks, computer sources, and the authors vast personal experience, outlines of more than 400 clinical protocols help ensure that everyone on the team is on the same page.. Flowcharts and algorithms make common problems seem simpler. Tables and decision trees make the information easy to refer to when running from room to room during a busy day in the office or hospital. This complete, up-to-date coverage makes Clinical Protocols in Obstetrics and Gynecology, Third Edition the best available study guide for board certification and a complete reference for busy obstetricians and gynecologists ...
A central goal of The Academy of Breastfeeding Medicine is the development of clinical protocols for managing common medical problems that may impact breastfeeding success. These protocols serve only as guidelines for the care of breastfeeding mothers and infants and do not delineate an exclusive co …
Moderna has just announced that its RNA based vaccine is starting a phase 3 clinical trial with 30,000 subjects, so I thought it might be useful to take a look at the publicly available information about the trial, and how they got there. Lets go logically and chronologically and start with the phase 1 safety study. The Phase 1 study A phase 1 study is a safety study. They usually have relatively few subjects, and different doses are given because dosing in terms of side effects is usually an important endpoint in a safety study. Here is the Brief Summary of the Phase 1 study published by Moderna Brief Summary: This is a phase I, open-label, dose-ranging clinical trial in males and non-pregnant females, starting at 18 years of age, inclusive, who are in good health and meet all eligibility criteria. This clinical trial is designed to assess the safety, reactogenicity, and immunogenicity of mRNA-1273 manufactured by ModernaTX, Inc. mRNA-1273 is a novel lipid nanoparticle (LNP)-encapsulated mRNA-based
Self-monitoring of blood glucose in patients with diabetes has traditionally been considered to be a pillar of diabetes self-care. Scientific examinations of SMBG in T2DM have provided mixed results. An early epidemiological evaluation of the issue using a retrospective, longitudinal analysis showed that nonfatal micro- and macrovascular event rates along with fatal event rates were lower in individuals performing SMBG routinely as compared to those who were not [3]. A multitude of clinical trials followed. Several showed a significant benefit from SMBG testing on improving glycemic control [4-7], while others found no evidence of benefit [16]. In fact, some studies even suggested harm from routine SMBG in patients with T2DM, specifically, higher rates of depression and increased cost without accompanying benefits [31].. Given these mixed results, a series of meta-analyses and systematic reviews were conducted to investigate the benefit or lack thereof of SMBG on glycemic lowering in patients ...
Discussion. We found that ACPAP simplified and facilitated the effective management of patients at intermediate risk of adverse cardiac events at our hospital. Two-thirds of patients assessed with ACPAP were reclassified as low risk and discharged early a mean of 14 hours after presentation, allowing early return to work and normal activities; 1% of these patients had cardiac events (all elective revascularisations) by six-month follow-up, compared with 19% of high-risk patients. We have identified no missed AMIs since adopting the protocol. However, a low rate of missed AMI depends on the willingness of emergency staff to enrol patients with both typical and atypical symptoms in the protocol, particularly the elderly and those with diabetes, whose presentations are often atypical or even silent.. A limitation of the study was that it was a clinical audit and not a prospective controlled trial of differing strategies in managing chest pain. However, although observational, our study had ...
JoVE publishes peer-reviewed scientific video protocols to accelerate biological, medical, chemical and physical research. Watch our scientific video articles.
if the rapid assessment is to be useful for guiding emergency health response, it must be clear in advance which individuals make the decisions on emergency interventions because they must receive the information and recommendations made
When you express interest in a specific study, the information from your profile will be sent to the doctor conducting that study. If youre eligible to participate, you may be contacted by a nurse or study coordinator. If you select a health category rather than a specific study, doctors who have active studies in that area may contact you to ask if you would like to participate. In both cases, you will be contacted by the preferred method (email or phone) that you specified in your profile. ...
The WHO Regional Office for Europe is revising five clinical protocols on treatment of and care for people with HIV and AIDS, which were part of the 13 protocols set combined in one volume in 2007.. The protocols are the cornerstone of the strategic actions that WHO has taken as part of its contribution to ensure universal access to treatment and care for people living with HIV and to comprehensively address their health problems, including preventing and treating co-infections and co-morbidities - one of the six priority areas of the European Action Plan for HIV/AIDS 2012-2015.. Addressing the diverse capacity of the countries in the WHO European Region to implement recommendations, the revised protocols provide preferable, alternative and acceptable options which allow countries to choose appropriate recommendations depending on the available resources. Five revised clinical protocols are envisaged for publication this year.. ...
The condition of effectiveness is not fully fulfilled - the new unified clinical protocol was developed based on evidentiary medicine, however the focus is made on the compliance with clinical efficacy without due consideration of the economic aspect. For example, in cases when resistance profile is not known (for a term of 2 months), it is economically more advantageous to start treatment with more expensive and more effective treatment regimen, as not only the cost of medication should be accounted but the cost of a patients stay in a hospital as well (which includes not only material costs but also psychological challenge for a patient to be apart from his/her usual social environment for a long time). Another example: according with WHO recommendations, for diagnosis with molecular DNA tests, there should be developed extended criteria regarding the patients who must undergo such tests; however, such criteria in the applicable unified clinical protocol are essentially restricted (article ...
TY - CHAP. T1 - Best Practices in Evaluating Novel Biomarker Fit for Purpose and Translatability. AU - Baker, Amanda F. PY - 2016/1/1. Y1 - 2016/1/1. N2 - This chapter discusses various tactical aspects to consider when evaluating novel biomarker translatability. The evaluation procedures warrant careful attention in order to leverage the most appropriate traditional and novel biomarkers in the relevant biological matrices. Integration of biomarkers into clinical protocols requires incorporation of biomarker analysis into one of the study objectives. The chapter also describes the use of fit-for-purpose biomarkers in different phases of drug development. When translating a biomarker from preclinical to clinical studies, the species specificity of the assay should be evaluated. Evidence-based protocols for sample collection should be developed and implemented for each biomarker analyzed. When multiple biomarkers are to be analyzed, multiple types of collection containers/tubes may be necessary. ...
Dear colleagues and visitors to our site! Entered into force Clinical Protocol for the diagnosis and treatment of tuberculosis (adult and pediatric population), which you can find on our website in the section Organizational and methodological work -, Legal acts on service. Dear colleagues and visitors to our site! Entered into force Clinical Protocol for the diagnosis and treatment of tuberculosis (adult and pediatric population), which you can find on our website in the section Organizational and methodological work -, Legal acts on .... Readmore ...
This Website Provides Over 10000 Free Medical Books and more for all Students and Doctors This Website the best choice for medical students during and after learning medicine.
Special Note 1.2: Processing and handling of CSF for analysis - please remember endotoxin is ubiquitous and can change expression of all mediators being assayed. Endotoxin free precautions should be taken for handling of all procedures (sterile precautions and using endotoxin free solutions should suffice ...
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The Essentials of Clinical Research course is designed for faculty and staff engaged in clinical research at Stanford and will consist of 10 sessions. The course introduces attendees to basic principles of clinical research design, including biostatistics; design and interpretation of diagnostic and predictive test studies; required and desired elements of clinical trial protocols. The course will also introduce regulatory aspects of clinical research conduct and oversight, Good Clinical Practice (GCP), and ethical dimensions of clinical research.. Sessions are held on Thursdays from 3:30 - 5:30 pm beginning January 9 through March 12, 2020.. For more information regarding course content, instructors, and logistics download the course syllabus:. ...
Analyze data Analytical skills Control data Develop clinical trial protocols Develop protocols Guide students Interact with nurses Interact with physicians Interpret data Monitor a clinical study Report data Search literature on clinical trials Write papers Write protocolsAdjust processes and methodsassess the needs of the project(s)/program(s) and make changes in process, work flow and/or assignments.Assign activitiesAssist with experimentsAssist with proceduresAttend at steering committee meetingsAttend investigator meetingAttend seminarsAttend seminars, courses and meetings within and outside the companyCalculate timelines for conducting and completing the trialClinical data collectionCoachcollaborate in research projects at universitiesCollaborate with medical teamCollaborate with principal investigatorCollaborate with project teamCollect dataCommunicate with investigatorCommunicate with sponsorConduct animal studiesConduct literature searchesConduct research at universitiesConduct ...
Investigates the clinical subject area provided in the sponsors RFP in order to define the scope of the clinical trial; Researches pertinent scientific/clinical information that may include, but is not limited to: disease background (etiology, epidemiology, statistical information, symptoms, and methods of diagnosis), current standards of care (treatments methods), how the sponsor-proposed intervention fits into the current treatment landscape, and information regarding competing therapeutics in clinical development. This information is augmented with a critical evaluation of the clinical trial protocol and supporting documents, to proactively identify study strengths and potential pitfalls ...
There are many reasons why clinical trials dont work well. A major one is not making them useful or interesting to patients. I had high hopes when I heard about the recent clinical trial protocol (plan) template from the U.S. Food & Drug Administration (FDA) and the National Institutes of Health (NIH) Joint Leadership Council (JLC). Unfortunately, it looks like they…
This study suggests that, compared with conventional management, a treatment programme for failure to thrive delivered by health visitors using strict diagnostic criteria and assessment protocols, with limited additional support, results in a weight gain of around half an intercentile space using UK charts, equivalent to about 550 g. This was despite only just over half of the intervention group receiving the full programme, because a fifth showed prior spontaneous recovery and another quarter exercised their right to decline aspects of the programme. The fairly low levels of compliance with the follow up home visit were also disappointing, but compliance rates were similar in both arms, and those interviewed were representative of the original group. It is fortunate, however, that routine follow up weights were also retrieved for a high proportion of the group, which also showed a significant treatment benefit.. The severity of failure to thrive found in this cohort was similar to previous ...
Licensed Associate Counselor | Portrait Health Centers are multi-specialty clinics that employ the most cutting-edge and proven assessment protocols and treatment options available, believing that an Effective Treatment Depends On An Accurate Diagnosis. Individuals should not have to
Prior to being applied to the new bisphenol A (BPA) re‐evaluation, the study appraisal methodology described in the 2017 BPA hazard assessment protocol, i.e. the so‐called 2017 methodology, was tested on a selection of studies that had been previously a .... ...
Prior to being applied to the new bisphenol A (BPA) re‐evaluation, the study appraisal methodology described in the 2017 BPA hazard assessment protocol, i.e. the so‐called 2017 methodology, was tested on a selection of studies that had been previously a .... ...
The Imaging Translational Technology Core (Imaging TTC) facilitates one-on-one consultation with imaging experts for study design, imaging protocol development and study implementation. The core facilitates integrated use of imaging resources in translational projects and clinical trials and offers research imaging management infrastructure through the Johns Hopkins Medical Image Research Archive Center for research data storage and distribution Imaging also offers CORIS, a one week observership program for anyone interested in radiology. Participants have an opportunity to shadow Katarzyna (Kasia) J. Macura, MD, PhD, FACR, Professor of Radiology, Urology and Oncology. For more information and to schedule a time, contact Atefeh Ameri at … Continue reading →. ...
It is well accepted that the clinical features of patients with HPV-driven HNSCC are distinct from those of patients with HPV-negative disease. These include distinct sites of origin of the disease (e.g., tonsil and base of tongue), younger age, and improved relapse-free survival following initial definitive treatment. Clinically, an emphasis on protocol development for patients with HPV-driven HNSCCs has consisted largely of de-escalation of standard therapy with a lower dose of radiation, more limited resection, or deintensification of chemotherapy.. Initial NGS studies of HPV-positive patients confirmed that these individuals harbor few genomic alterations in TP53 and/or CDKN2A, presumably due to the activity of the HPV E6 and E7 viral oncoproteins (11). These studies also suggested that HPV-driven HNSCCs display less genomic complexity as compared with HPV-negative disease, though TCGA and other more recent cohorts did not confirm this finding, perhaps due to tobacco use in the HPV-positive ...
Find standardized, evidence-based protocols for cholesterol management, tobacco cessation, and hypertension treatment to use in your practice.
Abstract the protocol implementation, including threading, etc. Processor is single threaded and specific to stream-based protocols, will not fit Jk protocols like JNI ...
Abstract the protocol implementation, including threading, etc. Processor is single threaded and specific to stream-based protocols, will not fit Jk protocols like JNI ...
The experts of ICMRs National Task Force for Covid-19 and the Joint Monitoring Group held its meeting on Thursday to deliberate on whether the drug should be included in the national treatment guidelines
This multicenter randomized trial assigned patients 1341 patients to protocol EGDT (Early Goal Directed Therapy), protocol-based standard therapy that did not require the placement of a central venous catheter, administration of inotropes, or blood transfusions or usual care which was not standardized. The data was analyzed with intention to treat to determine in protocolized treatment of sepsis had a mortality benefit as was shown in the original Rivers Trial. No significant 60 or 90 day mortality benefit was found to the protocol therapy and greater hospital resources such as ICU admissions were found in the protocol based groups. ...
This is the first multi-district Standardised Patient (SP) study in South Africa. It measures the quality of TB screening at primary healthcare (PHC) facilities. We hypothesise that TB screening protocols and best practices are poorly adhered to at the PHC level. The SP method allows researchers to observe how healthcare providers identify, test and advise presumptive TB patients, and whether this aligns with clinical protocols and best practice. The study was conducted at PHC facilities in two provinces and 143 interactions at 39 facilities were analysed. Only 43% of interactions resulted in SPs receiving a TB sputum test and being offered an HIV test. TB sputum tests were conducted routinely (84%) while HIV tests were offered less frequently (47%). Nurses frequently neglected to ask SPs whether their household contacts had confirmed TB (54%). Antibiotics were prescribed without taking temperatures in 8% of cases. The importance of returning to the facility to receive TB test results was only explained
Hi, Currently in middle of third year nursing essay. Anyone have any idea where to get a definition of clinical protocols and standards - really stuck! Cheers Trigger x
I had a wee meeting to finalise my anticipatory care plan for when I need to go into hospital. It was really good which is hopefully going to change quite a lot. I was nervous as this consultant is new and I have not known him long but I didnt need to worry. He was…
The instructions given here are for the original, and what I like to call, Classic Protocol 1000. If you do further research you will find that we and many other people have tried various versions of Protocol 1000 over the years. While most all of the slight variations of Protocol 1000 have been successful, according to reports we have received from around the world the success has never been as good as the original protocol of mixing the dose fresh every hour. Protocol 1000 is taking a maximum of 3 drops of activated MMS (MMS1) in 4 ounces/120 ml of water once each hour, for eight consecutive hours, every day, for three weeks or until well. Do not start out at 3 drops an hour. Try to build up to 3 drops slowly. If your body does not tolerate an increase of drops, stick with what works best for you. Your health may be recovered taking less than 3 drops in each dose. Some people have recovered their health taking 1 or 2 drops per hour, and in rare cases even less. It is best to start out slow and ...
List of Protocol pages. To create a protocol page please use the following naming convention: Kubke_Lab:Protocols/Protocol_name ...
Jul 3, 2014 ... Rather, our focus is on the ability of more exclusive approaches to ... 2 This is how the CBD defines genetic resources, Article 2, Use of .... 5 The exact temporal and functional scopes of the Nagoya Protocol are ... development and im... ...
Questions have been raised about Séralinis study protocol. But Séralini designed his study to be comparable with Monsantos - thus the design was similar.
As part of our efforts to make science more reproducible, were working with Bio-protocol to link the protocols they host with research published at eLife. To request a protocol for an eLife paper thats not yet available on Bio-protocol, simply fill in the form below and they will send a request to the author. If the author chooses to make it available, the Bio-protocol team will let you know via email and a link will be added to the eLife article. Your details will not be shared with the authors unless you opt-in to share them below. ...
As part of our efforts to make science more reproducible, were working with Bio-protocol to link the protocols they host with research published at eLife. To request a protocol for an eLife paper thats not yet available on Bio-protocol, simply fill in the form below and they will send a request to the author. If the author chooses to make it available, the Bio-protocol team will let you know via email and a link will be added to the eLife article. Your details will not be shared with the authors unless you opt-in to share them below. ...
Rationale: Stroke and poststroke depression are common and have a profound and ongoing impact on an individuals quality of life. However, reliable biological correlates of poststroke depression and functional outcome have not been well established in humans. Aims: Our aim is to identify biological factors, molecular and imaging, associated with poststroke depression and recovery that may be used to guide more targeted interventions. Design: In a longitudinal cohort study of 200 stroke survivors, the START - STroke imAging pRevention and Treatment cohort, we will examine the relationship between gene expression, regulator proteins, depression, and functional outcome. Stroke survivors will be investigated at baseline, 24h, three-days, three-months, and 12 months poststroke for blood-based biological associates and at days 3-7, three-months, and 12 months for depression and functional outcomes. A sub-group (n=100), the PrePARE: Prediction and Prevention to Achieve optimal Recovery Endpoints after ...
On successful completion of this module students should be able to: Demonstrate a detailed knowledge of the epidemiological and pathophysiological evidence which underpins current guidelines for the inclusion of physical activity in the maintenance of a healthy lifestyle; Demonstrate an awareness of pre-assessment screening, risk stratification and issues related to the selection of safe and appropriate physiological assessment protocols for both healthy individuals and those suffering from chronic disease; Interpret and evaluate data from physiological assessment protocols and demonstrate an awareness of validity and reliability issues ...
Given the continued destruction, disturbance and fragmentation of tropical forests, and the associated extinction of species (Sayer & Whitmore 1991; May, Lawton & Stork 1995; Turner 1996), there is an urgent need to develop and test standardized methods for sampling biodiversity (Sutton & Collins 1991; Stork & Samways 1995). This has prompted a growing literature on the search for bioindicators, particularly for insects, because they form the bulk of species and animal biomass in terrestrial habitats and have a strong influence over many ecosystem processes. McGeoch (1998) reviewed the selection and utility of insects as indicators, and emphasized the need for explicit aims and hypothesis testing when nominating a species or group of taxa as a bioindicator. The basic purpose of bioindicators, whatever the ultimate aim, is to indicate a relationship with another biotic or abiotic variable. These relationships with other variables are, however, only as good as the sampling method employed to ...
The Integrative Cartilage Research Group at the University of Melbourne researches links between microstructure, mechanics and biological signalling networks.. Glycosaminoglycans, collagen, DNA, and mineral content are just some of the markers used to understand biological tissue quality. Reproducibly extracting and measuring these markers from small structures (e.g. mouse knees) can be challenging. In this work, we are developing robust in vivo protocols that will form the foundation for future research projects.. The ICR Group is developing, refining, and using biomedical engineering tools and concepts, to explore and understand the effects of mechanics on living musculoskeletal systems on the molecular, cellular, and organ level of organisation, while maintaining a philosophy of respect and compassion for all human and animal life.. The project involves monitoring of biosignals and biomarkers in biological constructs and in vivo animal models. The work requires a creative approach to ...
Explicate the Management Strategies and Strategic Components to Identify Structural Practices (Participants: approximately 5775 online participants).. We propose to use an iterative online engagement strategy based on the Qualtrics [40] platform to explore variation in Management Strategies and Structural Practices focused on HAI-prevention across an initial sample of hospitals. In this step, we will build a survey instrument and deploy a computer-assisted Delphi method to conduct this assessment. The Delphi method is an iterative engagement technique where knowledgeable individuals are systematically asked a series of questions in multiple rounds of queries in five process stages, Preparation, Generation, Structure, Analysis, and Summary. Throughout this process, the research team will provide summaries of results to participants as findings emerge across the different participants perspectives. The Delphi study stages are explained below.. Stage 1, Preparation will involve identification of ...
|strong|Introduction|/strong|: Zambias under-resourced public health system will not be able to deliver on its health-related Millennium Development Goals without a substantial acceleration in mortality reduction. Reducing mortality will depend not only upon increasing access to health care but also upon improving the quality of care that is delivered. Our project proposes to improve the quality of clinical care and to improve utilization of that care,through a targeted quality improvement (QI) intervention delivered at the facility and community level. |strong|Description of implementation|/strong|: The project is being carried out 42 primary health care facilities that serve a largely rural population of more than 450,000 in Zambias Lusaka Province. We have deployed six QI teams toimplement consensus clinical protocols, forms, and systems at each site. The QI teams define new clinical quality expectations and provide tools needed to deliver on those expectations. They also monitor the care that
In recent years, evidence-based protocols of bundled therapies have improved survival of severe sepsis in developed countries. In sub-Saharan Africa, simple therapies such as IV fluids and early antibiotics are frequently under-utilized. Studies of fluid interventions in the region, however, have demonstrated conflicting results. Outcomes in septic patients may be further affected by delays in the diagnosis of tuberculosis-associated severe sepsis.. The aims of this study are (1) To assess the impact on survival of a simple evidence-based protocol for severe sepsis with hypotensionor septic shock, (2) To evaluate the cost of implementation for a simplified severe sepsis protocol, (3) To develop a clinical diagnostic score for identifying tuberculosis in HIV positive patients with severe sepsis, and (4) To assess the performance of the Xpert TB/RIF rapid PCR system and urine lipoarabinomannan assay for diagnosing tuberculosis in HIV positive patients with severe sepsis. ...
In recent years, evidence-based protocols of bundled therapies have improved survival of severe sepsis in developed countries. In sub-Saharan Africa, simple therapies such as IV fluids and early antibiotics are frequently under-utilized. Studies of fluid interventions in the region, however, have demonstrated conflicting results. Outcomes in septic patients may be further affected by delays in the diagnosis of tuberculosis-associated severe sepsis.. The aims of this study are (1) To assess the impact on survival of a simple evidence-based protocol for severe sepsis with hypotensionor septic shock, (2) To evaluate the cost of implementation for a simplified severe sepsis protocol, (3) To develop a clinical diagnostic score for identifying tuberculosis in HIV positive patients with severe sepsis, and (4) To assess the performance of the Xpert TB/RIF rapid PCR system and urine lipoarabinomannan assay for diagnosing tuberculosis in HIV positive patients with severe sepsis. ...
Because the advantages of clinical trials registries are so great and because several forces now demand their creation, the challenge is to develop systems that will be accessible to a range of persons and serve a range of interrelated purposes (39). Given these broad goals, several authors have suggested the types of elements that should be included in a clinical trials registry (7, 22, 25, 27). All agree on the high-level categories of information that should be present in a full clinical trials protocol (40), although there are differences in the emphasis placed on those categories. General and administrative information includes the trial name or title, a registration number, the funding source, the site at which the trial is being conducted, the name and affiliation of the investigators, the study start and completion dates, and the recruiting status of the trial. The purpose and objectives of the trial include the disease or condition being treated or evaluated, the treatments or ...
Infertility is defined as inability of a couple to conceive naturally after one year of regular unprotected sexual intercourse. It remains a major clinical and social problem, affecting perhaps one couple in six. Evaluation usually starts after 12 months; however it may be indicated earlier. The most common causes of infertility are: male factor such as sperm abnormalities, female factor such as ovulation dysfunction and tubal pathology, combined male and female factors and unexplained infertility. The aim of this study is to provide the healthcare professionals an evidence-based management protocol for infertile couples away from medical information overload. A comprehensive review where the literature was searched for
Skaga, Erlend; Kulesskiy, Evgeny; Brynjulfsen, Marit; Sandberg, Cecilie Jonsgar; Kyttala, Aija; Langmoen, Iver Arne; Laakso, Aki; Gaal-Paavola, Em-Lia; Perola, Markus; Wennerberg, Krister; Vik-Mo, Einar ...
BACKGROUND AND AIMS: Several changes in the management protocols of anaesthesia for geriatric patients were introduced into clinical practice to improve the outcome. Very few studies have evaluated the impact of these management protocols. The aim of our study was to evaluate impact of some of the changes in the peri-operative management protocols of geriatric patients undergoing elective orthopaedic lower limb surgeries on the outcomes. METHODS: A retrospective chart review of thirty-eight surgical patients from 1999 (Group 1999) before the introduction of changes and 107 patients from 2007 (Group 2007) after establishing changes was performed and data of peri-operative variables were collected and analysed ...
François Chapuis and colleagues examine a cohort of clinical trial protocols approved by French ethics committees, and show that Phase I trials are less frequently published than other types of trials.
François Chapuis and colleagues examine a cohort of clinical trial protocols approved by French ethics committees, and show that Phase I trials are less frequently published than other types of trials.
The trial was registered as a clinical trial with the Australian and New Zealand Clinical Trials Registry ( ACTRN12614001064695 ) on the 3rd of October 2014 - registered retrospectively.
Prednisone didnt make. This is why I wait at least three months. kept them satiated without feeling hungry all day.Most of them did fine on.Clinical trial protocol. Treatment repeats every 3 weeks until day 365 from the beginning of. *Patients receive oral prednisolone 3 times daily on.. prednisone 20 mg tablets for dogs, prednisone 10 mg package insert, prednisone 20 mg 3 times daily, buy prednisone dose pack, prednisone 20 mg dosing.area 2-3 times a day. eur-lex.europa.eu. ES A method for preparing a transdermal absorptive drug formulation containing 3-isobutyryl-2-isopropylpyrazolo.. Avoid contact with people friday glucocorticoid effects of prednisone 3 minutes for. not potentiate the beta times times the anti. teens consume each day.3) Accords barrés (avancé) 4) Les power chords; Accords à 4 sons. 1) Les accords 7ème de dominante; 2) Les accords Majeurs 7 ouverts; 3) Transposition des accords.To help acne how to take 10mg 6 5 4 3 2 1 50lb dog 50mg prednisone thrombocytopenia heart ...
Nivestim 12 MU/ 0.2 ml solution for injection/infusion, Nivestim 30 MU/ 0.5 ml solution for injection/infusion, Nivestim 48MU/ 0.5 ml solution for injection/infusion - Summary of Product Characteristics (SmPC) by Hospira UK Ltd
Three randomized clinical trials have recently provided data on the lack of effectiveness of early-goal directed therapy (EGDT) (i.e. optimization of tissue oxygenation in the first 6 hours since sepsis diagnosis using different therapeutic interventions based on the assessment of the central venous oxygen saturation to titrate such interventions) in the initial management of patients with septic shock. In a first trial including 31 US hospitals (the ProCESS study, N.=1341), three different therapeutic strategies (EGDT vs. protocol-based therapy vs. usual care) were compared and no difference in the primary endpoint (60-day mortality) was found (EGDT 21%, protocol-based therapy 18% and usual care 19%). No significant difference in death by 90 days or in other secondary outcomes, including serious adverse events, was found, as well. A second trial (ARISE, N.=1600), mostly conducted in Australia and New Zealand, randomized patients to EGDT or usual care. Ninety-day mortality was similar between ...
Assessment should begin with a review of the institutions mission statement and overall goals. What are the institutions priorities, and what evidence can demonstrate their achievement? How can the institution best combine summative assessment (which focuses on learners development at a particular time) and formative assessment (a more holistic approach that uses multiple points of measurement to provide continuous feedback and improve educational opportunities) to meet its goals? By answering these and related questions, administrators can determine which assessment methods and tools to use.. The next step in developing an assessment protocol is to explore the institutional context and available resources, including others who are already engaged in assessment. This process should lead to the creation of a multiunit assessment team, as the undertaking is too complex for any one office to implement. The team should develop an assessment plan and review it regularly for refinement. Table 1 ...
In order to achieve this, all clients must go through an initial consultation process so that together we can ascertain the level of intervention required for your success. The process includes a visual food diary analysis, remote Movement Assessment Protocol, and current situation assessment. Our conversations coupled with the data these tests provide enables the delivery of a suite of interventions which empower you to make positive changes and maintain that success. Crucially, you will be supported throughout the process, with access to personal, world class expertise monitoring your training, guiding your nutritional decisions and keeping you on track.. Achieve Your Objective is based on two decades worth of experience of working both in-person and remotely to help create solutions to the challenges that modern life presents to self-care. If you are pressed for time, and would like to take positive, supported steps to looking and feeling better, get in touch now or apply here ...
Subarachnoid hemorrhage, traumatic brain injury and cardiogenic shock are diseases that can be life-threatening and might require weeks of intensive medical care. Administration of medication is an essential part of the treatment. According to current practice, the route of drug administration in critically ill patients can be enteral or parenteral depending on the available drug format and vigilance of patients. However, there are many studies in the literature that report a disturbance of gastrointestinal function in critically ill patients. Therefore, the question of whether the enteral route of drug administration in critically ill patients is pharmacokinetically meaningful should be investigated in this study ...
The aim of this non-investigational study is to determine the symptoms and burden at the moment of diagnosis and in the further course of an incurable cancer disease. The needs and preferences of patients suffering from cancer (ovarian carcinoma, breast cancer, malignant melanoma, lung cancer, stomach cancer, oesophageal cancer, pancreatic cancer, cancer of the hepatobiliary system, colorectal cancer, head and neck cancer) will be examined by various questionnaires. The data obtained by these questionnaires will be collected together with information obtained by the treating physicians at four time points during the study: T0 - patient´s enrollment, at the moment of diagnosis and before the start of tumor therapy, respectively; T1 - 3 months after the patient´s enrollment; T2 - 6 months after the patient´s enrollment; T3 - 12 months after the patient´s enrollment. This highly innovative project offers the chance to identify medical services deficits and risk circumstances for the burden of ...
Students are required to engage in a research project of their own design under the supervision of the primary mentor. At the time of application, each student specifies the project they will pursue, along with the primary mentor who will supervise the research project. Students will use class material and homework assignments to assist in protocol development.. The research should be translational in nature and involve direct measurements on patient-derived samples or the use of innovative therapeutic or diagnostic techniques with laboratory-based elements. There should be demonstrable clinical relevance. The protocol is to be designed by the student under the direct supervision of the mentor. Where appropriate, dual mentorship should be considered; including a basic scientist expert in the technology being used and a clinical investigator expert in the condition being studied. The primary protocol should account for at least 75-80% of the students commitment to the program.. Trainees are ...
Provides support of protocol development and conduct through the Protocol and Information Office, PIO, as the operations hub, processes all submissions and liaisons with all clinical sites. OIB also developed and maintains the CTEP Enterprise System, in use by the NCI as well as the extramural community, to collect, analyze and report a wide variety of protocol, accrual, adverse event and agent information ...
This summary abstract describes the methodology used to evaluate the effect of pellet pellet and pellet clad interactions with consideration of the interfacial bonding efficiency on UNF vibration integrity. This methodology provides a solid roadmap for further protocol development with respect to effective lifetime prediction of a UNF system under normal transportation vibration. The proposed methodology that couples FEA simulations and experimental exploration efforts is also under development. The current methodology is focused on assessing the influence of interfacial bonding at the pellet pellet and the pellet clad interfaces on UNF vibration integrity. The FEA simulation results were also calibrated and benchmarked with the fatigue aging data obtained from reversible bending fatigue testing. ...
The intent of these learning modules is to provide consistent and concise information to all providers. The content of the Module has been reviewed by the Protocol Development and Review Sub-Committee, and, where applicable, includes the specific standing order, resource and reference material, and instructions for completing the Self-Learning Module to obtain continuing education credit. One hour of SAEMS continuing education credit may be issued following successful completion of the module.. EMS Self-Learning Modules. ...
Clinical Research, Clinical Study, Clinical Trial, and Clinical Protocol all concern the same topic. These terms are often used interchangeably to talk about scientific studies that use people to understand if new drugs, treatments and devices are safe and effective. Clinical studies cannot happen until basic research in a laboratory determines the new treatment, drug or device is successful and safe. Once basic research indicates scientific promise, the FDA must approve continuing the research and beginning to test in people. Carefully controlled and well-designed clinical trials are performed by highly trained medical professionals to understand how this new treatment will work in people. The clinical trial is trying to duplicate the promising lab results in people.. Clinical Trials are conducted in four phases that occur in sequential order. Each phase tends to have a different purpose and helps answer different questions. Each phase is considered a separate trial. After completion of each ...
As a resident computer scientist at NINDS Translational Neuroradiology Section (TNS) lab, Moayeri developed code that helped accelerate data-processing steps in experiments tied to spinal cord research and worked side by side with leading scientists conducting basic and clinical biomedical research. He also worked in the clinical center, which left him with a strong sense of validation that his contributions could make a difference.. Often, patients who come to the NIH come out of necessity, as the already established clinical protocols are not sufficient to help these patients, says Moayeri. Seeing how many people would come from all over the country to the NIH really led me to believe in what I was working on and gave me a new sense of purpose.. Moayeris work in the TNS lab focused on measuring and capturing data of MS disease evolution taken from magnetic resonance imaging (MRI). Examining MRI scans of spinal cord lesions, Moayeri isolated quantitative data. Typically, this ...
/PRNewswire/ -- Today, the U.S. Food and Drug Administration announced a new protocol for the development and registration of antimicrobial treatments for...
TY - JOUR. T1 - New protocol to visualize gene expression in intact and regenerating adult planarians by whole mount in situ hibridization. AU - Bueno, D. AU - Castillo, E. AU - Vispo, M. AU - Cebrià, F. AU - Bayascas, JR. AU - Saló, E. AU - Romero, R. PY - 1997/1/1. Y1 - 1997/1/1. M3 - Article. SP - 1. EP - 1. ER - ...
Enhanced recovery after surgery (ERAS) is a multidimensional approach to improving the care of surgical patients using subspecialty- and procedure-specific evidence-based protocols. The literature provides evidence of the benefits of ERAS implementat
The global development unfolds in collaboration between academia, pharmaceutical companies, health care professionals as well as patients. It includes the quality of medicines, global clinical protocols, and studies. This contributes to an increased understanding of global health aspects to the benefit of patients health (efficacy and safety) and the global societies health development. The regulatory staff works on a daily basis with these complex issues in order to guarantee that the development and continued market access of the medicines comply with international standards for quality, efficacy and safety. This has resulted in a growing demand for employees with high regulatory competences especially in eg. the pharmaceutical industry, health authorities and academia.. ...
Founded in 1994, Theralase Technologies Inc. designs, develops and manufactures super-pulsed, cool laser technology for a wide range of human, companion animal and equine applications. Theralase is committed to provide cutting-edge pre-clinical and clinical research to remain the most clinically and scientifically supported therapeutic medical laser on the market. The highly trained scientific, clinical and engineering Theralase team continuously brings our valued customers the most advanced technology on the market, while our sales, marketing, clinical training, customer service and finance teams bring superior customer service, the latest interactive training, the most up to date clinical protocols and the best financing options to accelerate the financial and clinical success of your practice. READ MORE ...
One can reduce the complexity of making a diagnosis of SLE by using conceptual models. There are two such models, one separate illnesses, the other linear illness; both cluster SLEs disparate elements. The separate illnesses model posits that typical, overlap, UAS and antibody-only SLE are separate but related illnesses. A strength of this model is that it assigns different, targetable biological mechanisms to each diagnosis. Another strength is that a diagnosis, once made, does not change.37-40 Weaknesses of this model are that, in clinical practice, ambiguous diagnoses occur often, blurring the separating lines, and that diagnoses do sometimes change. Clinical protocols that rigidly adhere to sharp distinctions among diagnoses may remove options available to the treating physician. Another weakness is that insights suggested by evolving phenotypes may be unseen if an investigator believes that change of diagnosis cannot occur.30 The linear illness model posits that UAS, overlap, antibody-only ...
Cabernet works closely with clients to understand their needs and goals and then deliver timely, executable clinical protocols that provide actionable answers for the key scientific, regulatory, and payer questions in all phases of drug development. We also develop study documentation, such as study-procedure manuals, informed consents, and clinicaltrials.gov summaries. We can create and manage external clinical-study committees including advisory, adjudication, and drug-safety monitoring boards.. ...
It is estimated that over half of current adults within Great Britain under the age of 65 will be diagnosed with cancer at some point in their lifetime. Medical Imaging forms an essential part of cancer clinical protocols and is able to furnish morphological, metabolic and functional information. The imaging of molecular interactions of biological processes in vivo with Positron Emission Tomography (PET) is informative not only for disease detection but also therapeutic response. The qualitative and quantitative accuracy of imaging is thus vital in the extraction of meaningful and reproducible information from the images, allowing increased sensitivity and specificity in the diagnosis and precision of image guided treatment. Furthermore the utilization of complementary information obtained via Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) in integrated PET-CT and PET-MR devices offers the potential for the synergistic effects of hybrid imaging to provide increased detection and ...
Testing of methylation goes beyond MTHFR.. Learn about the methylation process, genetic testing for potential defects and clinical protocols for testing the methylation function and effective treatment options which include dietary changes and the proper supplementation.. This webinar will give you clinical and practical guidance in:. ...
In mouse, a subset of dendritic cells (DCs) known as CD8alpha+ DCs has emerged as an important player in the regulation of T cell responses and a promising target in vaccination strategies. However, translation into clinical protocols has been hampered by the failure to identify CD8alpha+ DCs in
Use IQ Scripts to gain control over your clinical processes. IQ Scripts define patient pathways and clinical protocols, and how MOSAIQ collects data.
Underwater transmission protocols may finally be unified in a protocol that aims to help interconnectivity with devices ranging from buoys to submarines.
Internet-Draft Routing Information Base Info Model October 2015 protocol-based RIB population suffices for most use cases where distributed network control is used. However there are use cases which the network operators currently address by configuring static routes, policies and RIB import/export rules on the routers. There is also a growing list of use cases [I-D.white-i2rs-use-case], [I-D.hares-i2rs-use-case-vn-vc] in which a network operator might want to program the RIB based on data unrelated to just routing (within that networks domain). Programming the RIB could be based on other information such as routing data in the adjacent domain or the load on storage and compute in the given domain. Or it could simply be a programmatic way of creating on-demand dynamic overlays (e.g. GRE tunnels) between compute hosts (without requiring the hosts to run traditional routing protocols). If there was a standardized publicly documented programmatic interface to a RIB, it would enable further ...
Interested in posting a protocol on OpenWetWare? Here is a template to help you do so. Click the view source tab and copy everything below this line. Paste it into your new protocol page. Then replace the text in this page with your own protocol. Feel free to add or delete sections as appropriate. ...
Clinicians have noted a high rate of delirium in COVID-19 patients in ICUs during the pandemic, which could be due to the use of heavy sedatives and safety protocols that limit family visitation.
"Clinical packages & Protocols". katetchanturia.com. "PEACE Pathway Website". peacepathway.org. Tchanturia, Kate, (2015). Brief ... Pathway for Eating disorders and Autism developed from Clinical Experience). This clinical pathway was funded by The Health ... After relocating to London in 1997, she became a clinical research fellow at the Institute of Psychiatry, King's College London ... She has developed a novel clinical pathway for patients with comorbid autism spectrum disorders and eating disorders at the ...
"Clinical protocol. Gene Therapy of Canavan Disease: AAV-2 Vector for Neurosurgical Delivery of Aspartoacylase Gene (ASPA) to ...
Limited clinical protocols for patient management. Limited technical operational manuals for program implementation. Health ...
Perlman, Sally E.; Nakajyma, Steven T.; Hertweck, S. Paige (2004). Clinical protocols in pediatric and adolescent gynecology. ... Perlman, Sally E.; Nakajyma, Steven T.; Hertweck, S. Paige (2004). Clinical protocols in pediatric and adolescent gynecology. ... Clinical and Pathological Aspects, Greenwich Medical Media: London, a)p.453, b)p.455 c)p.460. "Muslim women in France regain ...
Perlman, Sally E.; Nakajyma, Steven T.; Hertweck, S. Paige (2004). Clinical protocols in pediatric and adolescent gynecology. ... Clinical and Pathological Aspects, Greenwich Medical Media: London, a)p.453, b)p.455 c)p.460. The Marks of Childhood or the ... vaginal examinations for verifying a woman's virginity are a clinical practice which are at times state-enforced. These types ...
Perlman, Sally E.; Nakajyma, Steven T.; Hertweck, S. Paige (2004). Clinical protocols in pediatric and adolescent gynecology. ... US Navy protocols discourage the practice, while the other four branches have specific regulations against it. Legal tender ... Kopelman M. D.; Thomson A.D.; Guerrini I.; Marshall E.J. (2009). "The Korsakoff syndrome: clinical aspects, psychology and ... Weisberger, L; Jamieson, B (July 2009). "Clinical inquiries: How can you help prevent a recurrence of diverticulitis?". The ...
ISBN 978-0-7131-4452-9. Perlman SE, Nakajyma ST, Hertweck SP (2004). Clinical protocols in pediatric and adolescent gynecology ... ISBN 978-0-323-29358-7. Alldredge BK, Corelli RL, Ernst ME (2012). Koda-Kimble and Young's Applied Therapeutics: The Clinical ... ISBN 978-0-495-11308-9. Sirven JI, Malamut BL (2008). Clinical Neurology of the Older Adult. Lippincott Williams & Wilkins. pp ... ISBN 978-1-135-82509-6. Balon R, Segraves RT (2009). Clinical Manual of Sexual Disorders. American Psychiatric Pub. p. 258. ...
Perlman, Sally E.; Nakajyma, Steven T.; Hertweck, S. Paige (2004). Clinical protocols in pediatric and adolescent gynecology. ... Clinical and Pathological Aspects, Greenwich Medical Media: London, a)p.453, b)p.455 c)p.460. Heger, Astrid; Emans, S. Jean; ... Journal of Clinical Forensic Medicine. 13 (4): 172-180. doi:10.1016/j.jcfm.2006.02.006. ISSN 1353-1131. PMID 16564196. Hymen ...
... an invited group of clinicians met in Chicago and reviewed clinical evidence and protocols, and adopted a new term for intersex ... Large majorities of respondents opposed standard clinical protocols. A 2016 follow-up to the 2006 Consensus Statement, termed a ... a US professor of Clinical Medical Humanities and Bioethics, argues that little has changed in actual clinical practice in ... The committee stated: "clinical intervention pathways stated to be based on probabilities of cancer risk may be encapsulating ...
... an invited group of clinicians met in Chicago and reviewed clinical evidence and protocols, argued that and adopted a new term ... Large majorities of respondents opposed standard clinical protocols. A 2016 follow-up to the 2006 Consensus Statement, termed a ... There are no controlled clinical trials of the efficacy of early (less than 12 months of age) versus late surgery (in ... Clinical Pediatric and Adolescent Endocrinology.. Philadelphia: Saunders. An example of a now-obsolete recommendation to ...
"What stops hospital clinical staff from following protocols? An analysis of the incidence and factors behind the failure of ... These tools can predict clinical deterioration based upon the patient's trait (e.g. has epilepsy) and detect deterioration ... UK National Institute for Health and Clinical Excellence (NICE) (July 2007). "Acutely ill patients in hospital: recognition of ... A RRS consists of two clinical components (afferent and efferent) and two organizational components (process improvement and ...
Clinical Applications of Capillary Electrophoresis: Methods and Protocols. Methods in Molecular Biology. 1972. New York, NY: ...
ISBN 978-94-009-8195-9. Lt Col Pankaj Talwar; Surveen Ghumann Sindhu (18 May 2012). Step by Step: Protocols in Clinical ...
Clinical trial protocols are the centerpiece of the IND. Detailed protocols for proposed clinical studies to assess whether the ... If the FDA detects a problem, it may place a clinical hold on the IND, prohibiting the start of the clinical studies until the ... Once an IND is submitted, the FDA has 30 days to object to the IND or it automatically becomes effective and clinical trials ... About half of the INDs fail in preclinical and clinical phases of drug development. The FDA runs a medical marijuana IND ...
"ABM Clinical Protocol #11. 1 (1): 3. doi:10.1186/1746-4358-1-3. PMC 1464379. PMID 16722609.. ... Hanson LA, Söderström T (1981). "Human milk: Defense against infection". Progress in Clinical and Biological Research. 61: 147- ... Hendrickson RG, McKeown NJ (January 2012). "Is maternal opioid use hazardous to breast-fed infants?". Clinical Toxicology. 50 ( ... Haastrup MB, Pottegård A, Damkier P (February 2014). "Alcohol and breastfeeding". Basic & Clinical Pharmacology & Toxicology. ...
Wyatt, Richard Jed; Chew, Robert H. (2008). Wyatt's Practical Psychiatric Practice: Forms and Protocols for Clinical Use. ... The disappearance of residual and sub-clinical agoraphobic avoidance, and not simply of panic attacks, should be the aim of ... In the social sciences, a perceived clinical bias exists in agoraphobia research. Branches of the social sciences, especially ... Clinical Psychology Review. 30 (1): 37-50. doi:10.1016/j.cpr.2009.08.011. PMID 19775792. "Agoraphobia - Diagnosis and treatment ...
This experience includes clinical assessment, diagnosis, treatment, and referral protocols. The faculty at both CMCC and UQTR ... Candidates must successfully pass Components A and B (Written Cognitive Skills Examination) to be eligible for the Clinical ... Radiology training consists of more than 360 contact hours followed by application during clinical internship. CMCC and UQTR ... Canadian Chiropractic Examining Board requires all candidates to complete a 12-month clinical intership to obtain licensure, as ...
Forms and Protocols for Clinical Use. American Psychiatric Pub. pp. 142-. ISBN 978-1-58562-687-8. Katherine M. Fortinash; ... Larsson M, Axelsson R, Forsman A (1984). "On the pharmacokinetics of perphenazine: a clinical study of perphenazine enanthate ... Abstract.). 19th Annual Midyear Clinical Meeting of the American Society of Hospital Pharmacists. Dallas, Texas. Janssen PA, ... The Journal of Clinical Psychiatry. 45 (5 Pt 2): 50-9. PMID 6143748. Curry SH, Whelpton R, de Schepper PJ, Vranckx S, Schiff AA ...
MOMENTUM 3 IDE Clinical Study Protocol (HM3). U.S. National Institutes of Health. ClinicalTrials.gov. Retrieved September 16, ... is still in clinical trials for destination therapy. In a two-year randomized controlled clinical trial published in 2009 ... It began undergoing clinical trials in the U.S. and internationally in mid 2014. In mid 2014, CE Mark trials also started for ... It is cleared for clinical use up to six hours, and can be used as a short-term solution to support the circulation while ...
Spinifex Pharmaceuticals Pty Limited (2011). "CLINICAL STUDY PROTOCOL: Protocol No. EMA401-003". Cite journal requires ,journal ... Spinifex Pharmaceuticals Pty Limited (2011). "CLINICAL STUDY PROTOCOL: Protocol No. EMA401-003". Cite journal requires ,journal ... Spinifex Pharmaceuticals Pty Limited (2011). "CLINICAL STUDY PROTOCOL: Protocol No. EMA401-003". Cite journal requires ,journal ... Phase I clinical trial have indicated that doses of EMA401 up to 400 mg are safe in humans. Spinifex Pharmaceuticals reported ...
"Clinical Study Protocol mRNA-1273-P301" (PDF). Moderna. COVID-19 Vaccine Moderna assessment report European Medicines Agency " ... The clinical trial is ongoing and is set to conclude in late 2022. In November 2020, Nature reported that "While it's possible ... A review by the FDA in December 2020, of interim results of the Phase III clinical trial on mRNA-1273 showed it to be safe and ... The vaccine in low doses was deemed safe and effective in order to advance a Phase III clinical trial using two 100-μg doses ...
Weidmann, M.; Mühlberger, E.; Hufert, F. T. (2004). "Rapid detection protocol for filoviruses". Journal of Clinical Virology. ... "Journal of Clinical Microbiology. 40 (7): 2323-2330. doi:10.1128/jcm.40.7.2323-2330.2002. PMC 120575 . PMID 12089242.. ... "Clinical and Vaccine Immunology. 13 (4): 444-451. doi:10.1128/CVI.13.4.444-451.2006. PMC 1459631 . PMID 16603611.. ... "Journal of Clinical Microbiology. 45 (1): 224-226. doi:10.1128/JCM.01893-06. PMC 1828965 . PMID 17079496.. ...
Bagatto, M; Moodie, S; Scollie, S; Seewald, R; Moodie, S; Pumford, J; Liu, KP (2005). "Clinical protocols for hearing ... As with most clinical tests, standardized calibration of the test environment, the equipment and the stimuli is needed before ... Although pure-tone audiometry has many clinical benefits, it is not perfect at identifying all losses, such as 'dead regions' ... Handbook of clinical audiology. Katz, Jack., Burkard, Robert, 1953-, Medwetsky, Larry. (5th ed.). Philadelphia: Lippincott ...
The clinical protocol began on May 22, 1989, and included 10 patients. The procedure was shown to be safe. Rosenberg went on to ... Only after approval by that formal public governmental review did the gene therapy clinical protocol move on for review by the ... Microinjecting a few non-stem cells was clearly not an efficient procedure for a clinical protocol. In 1984, Anderson published ... Anderson, together with bioethicist John Fletcher, set the ethical standard for this type of clinical protocol in his 1980 ...
Postmortem microbiology in sudden death: sampling protocols proposed in different clinical settings. Clinical Microbiology and ... Forensic toxicology is the use of toxicology and other disciplines such as analytical chemistry, pharmacology and clinical ...
Typical stimulation protocols used in clinical FES involves trains of electric pulses. Biphasic, charged balanced pulses are ... Initial Phase II clinical trials conducted with FEST for reaching and grasping, and walking were carried out at KITE, the ... Taylor PN, Burridge JH, Dunkerley AL, Wood DE, Norton JA, Singleton C, Swain ID (1999). "Clinical use of the Odstock dropped ... initial clinical results". Artificial Organs. 26 (3): 267-270. doi:10.1046/j.1525-1594.2002.06949.x. PMID 11940030.CS1 maint: ...
These include protocol development, clinical site collaboration and management; randomization and trial supply management; ... Medidata Rave Clinical Cloud, introduced in 2013, is a platform used for data capture and management of patient-related data ... The company acquired Clinical Force in July 2011, Patient Profiles in October 2014, Intelemage in April 2016, Chita in February ... Medidata offers a cloud-based platform for clients to build their own clinical trials and perform medical research. On the ...
Pediatric AIDS Clinical Trials Group Protocol 076 Study Group". N Engl J Med. 331 (18): 1173-80. doi:10.1056/ ... Several months later, a phase 1 clinical trial of AZT at the NCI was initiated at the NCI and Duke University,. In doing this ... AZT is now a principal part of the clinical pathway for both pre-exposure prophylaxis and post-exposure treatment of mother-to- ... NIH Clinical Center's 50th Anniversary. "Archived copy" (PDF). Archived from the original (PDF) on June 19, 2013. Retrieved ...
Pediatric AIDS Clinical Trials Group Protocol 076 Study Group". The New England Journal of Medicine. 331 (18): 1173-80. doi: ... Early data from pre-clinical studies established the efficacy of AZT in preventing transmission of HIV infection. AZT was also ... and/or hepatitis A vaccine may be used as PEP depending on the clinical situation. If the person exposed is an HBsAg positive ... Clinical Research Ed.). 359: j5011. doi:10.1136/bmj.j5011. PMC 6020995. PMID 29229609. Saundra Young (4 March 2013). " ...
"British Journal of Clinical Pharmacology. 54 (6): 577-82. doi:10.1046/j.1365-2125.2002.01699.x. PMC 1874503. PMID 12492603.. ... Research into alternative therapies often fails to follow proper research protocols (such as placebo-controlled trials, blind ... clinical statisticians and pharmacologists, use clinical trials to reveal such effects, allowing physicians to offer a ... "British Medical Journal (Clinical Research Ed.). 287 (6388): 307-08. doi:10.1136/bmj.287.6388.307. PMC 1548588. PMID 6307462. ...
"Clinical Genetics: A Self-Study Guide for Health Care Providers. University of South Dakota School of Medicine. Archived from ... Methods and Protocols, Methods in Molecular Biology, Springer US, 2072, pp. 15-25, doi:10.1007/978-1-4939-9865-4_3, ISBN ... Methods and Protocols, Methods in Molecular Biology, Springer US, pp. 15-25, doi:10.1007/978-1-4939-9865-4_3, ISBN ...
Free clinical education programs are prehospital care, emergency department & hospital programs, and nursing school program. ... and embryo selection protocols. The research achievements from the Institute received both praise and criticism. The works have ...
Archer CB, Cohen SN, Baron SE (May 2012). "Guidance on the diagnosis and clinical management of acne". Clinical and ... This scale was the first to use a standardized photographic protocol to assess acne severity; since its creation in 1979, the ... Marchetti PM, Barth JH (March 2013). "Clinical biochemistry of dihydrotestosterone". Annals of Clinical Biochemistry. 50 (Pt 2 ... Brandt S (May 2013). "The clinical effects of zinc as a topical or oral agent on the clinical response and pathophysiologic ...
Clinical observations[edit]. A study involving 2408 donors (18-60 years) indicated that bone pain (primarily back and hips) as ... 2008). "Clinical applications of blood-derived and marrow-derived stem cells for nonmalignant diseases". JAMA. 299 (8): 925-36 ... Clinical and Experimental Rheumatology. 34 (4 Suppl 98): 53-57. ISSN 0392-856X. PMID 27586805.. ... hepatomegaly and fluid retention are clinical hallmarks of this condition. There is now a greater appreciation of the ...
Clinical laboratory sciences are the clinical diagnostic services that apply laboratory techniques to diagnosis and management ... which allows as much of the available evidence as possible to be collected and analyzed according to standard protocols that ... Subspecialties include transfusion medicine, cellular pathology, clinical chemistry, hematology, clinical microbiology and ... Some related clinical specialties include neurology, neurosurgery and psychiatry.. *Nutrition science (theoretical focus) and ...
... should be used only in the context of a clinical trial or research protocol. While cerclage is generally a safe procedure, ... However, large randomized clinical trials in singleton and twin pregnancies found that the cervical pessary did not result in a ... "The role of cervical pessary placement to prevent preterm birth in clinical practice". American Journal of Obstetrics and ...
Clinical trials have been conducted on mice using tomatoes expressing antibodies or proteins that stimulate antibody production ... from which to create juice to test in clinical trials on the way to obtaining regulatory approval.[37][38] ...
"European Journal of Clinical Chemistry and Clinical Biochemistry (Submitted manuscript). 32 (9): 685-9. doi:10.1515/cclm. ... A two-tiered protocol is recommended by the Centers for Disease Control and Prevention (CDC): the sensitive ELISA test is ... Stanek G, Reiter M (April 2011). "The expanding Lyme Borrelia complex--clinical significance of genomic species?". Clinical ... clinical practice guidelines by the Infectious Diseases Society of America". Clinical Infectious Diseases. 43 (9): 1089-134. ...
"International Journal of Clinical Practice. 66 (10): 940-47. doi:10.1111/j.1742-1241.2012.03004.x. PMC 3506737 . PMID 22994328. ... which relies on a drop table and detailed procedural protocols), Gonstead (which emphasizes evaluating the spine along with ... "Int J Clinical Practice. 64 (8): 1162-65. doi:10.1111/j.1742-1241.2010.02352.x. PMID 20642715.. ... Numerous controlled clinical studies of treatments used by chiropractors have been conducted, with conflicting results.[4] ...
The first use of X-rays under clinical conditions was by John Hall-Edwards in Birmingham, England on 11 January 1896, when he ... "Radiation Doses of Various CT Protocols: a Multicenter Longitudinal Observation Study". Journal of Korean Medical Science. 31 ... "The first clinical X-ray made in America--100 years" (PDF). American Journal of Roentgenology. American Roentgen Ray Society. ... "A clinical audit of anatomical side marker use in a paediatric medical imaging department". Journal of Medical Radiation ...
Clinical Chemistry and Laboratory Medicine. 57 (5): 690-696. doi:10.1515/cclm-2018-0967. PMID 30427777.. ... as mobile phase in analytical or preparative protocols. ...
FISH is often used in clinical studies. If a patient is infected with a suspected pathogen, bacteria, from the patient's ... Fibre FISH protocol from the Human Genome Project at the Sanger Centre ... Hybrid Fusion FISH enables highly multiplexed FISH applications that are targeted within clinical oncology panels. The ... and clinical relevance". Fertility and Sterility. 93 (6): 1892-902. doi:10.1016/j.fertnstert.2008.12.139. PMID 19254793.. ...
Clinical conditions. Many clinical conditions can cause disturbances to normal urination, including:. *Urinary incontinence, ... Steven R. Lindsay (9 January 2008). Handbook of Applied Dog Behavior and Training, Procedures and Protocols. John Wiley & Sons ...
Wittig, I.; Braun, H. P.; Schägger, H. (2006). "Blue native PAGE". Nature Protocols. 1 (1): 418-428. doi:10.1038/nprot.2006.62 ... clinical relevance and in vitro analysis of the function of the outer blood-retinal barrier". Developments in Ophthalmology. ... Pink, M.; Verma, N.; Rettenmeier, A. W.; Schmitz-Spanke, S. (2010). "CBB staining protocol with higher sensitivity and mass ...
Marise A. Hussey, Anne Zayaitz Endospore Stain Protocol Microbe Library (American Society of Microbiology) ... Murray, Patrick R.; Ellen Jo Baron (2003). Manual of Clinical Microbiology. 1. Washington, D.C.: ASM.. .mw-parser-output cite. ...
"Soman and sarin: clinical manifestations and treatment of accidental poisoning by organophosphates". Clinical Toxicology 7 (1 ... "1925 Geneva Protocol". United Nations Office for Disarmament Affairs. United Natios. Retrieved February 9, 2016.. ... Geneva Protocol of 1925: This agreement was signed on June 17, 1925, and took effect on February 8, 1928. It permanently bans ... The protocol was extended by the Biological Weapons Convention (1972) and the Chemical Weapons Convention (1993). ...
"Journal of Clinical Pathology 50 (5). Páxs. 365-370.. *↑ Craiem, D.; et al. (2008). "New Assessment of Endothelium-Dependent ... 2007). Current Protocols in Bioinformatics (en inglés). Wiley. ISBN 0-471-25093-7.. ... Transmission Control Protocol, Protocolo de control de transmisión) feito por Vinton Cerf e Robert Kahn (1974), un dos ... "Origins of... Image analysis in clinical pathology" ...
"Protocol School of Washington.. *^ "Summaries of Informal Opinions of the Standing Committee on Professional Ethics". American ... implementing elements such as clinical training, which has become an essential part of legal education in the U.S. and in the J ...
Such markers are often based on single cases described in clinical literature in the late nineteenth century. One such marker ... "Evaluating the efficiency of different recording protocols for entheseal changes in regards to expressing activity patterns ...
These include psychiatrists, psychiatry physician assistants, clinical psychologists, occupational therapists, clinical social ... It is not the intention of this article to explore the protocol of carrying out a proper TB test. A TB blood test for baseline ... These include physiatrists, physician assistants, rehabilitation nurses, clinical nurse specialists, nurse practitioners, ... They include geriatricians, occupational therapists, physician assistants, adult-gerontology nurse practitioners, clinical ...
... is one of only two programs in the United States approved to perform hand/arm transplants using an immunomodulatory protocol, ... group had performed extensive basic science research and feasibility studies for many years prior to their first clinical ...
... develop a new clinical cancer research unit at Northwell Health in Lake Success, NY, to support early-phase clinical studies of ... laboratory manuals and protocols, and online services for research preprints.[6] ... "ISIS initiates Phase 3 clinical trials for potential SMA therapy ISIS-SMNrx". The SMA Trust.. ...
Russell, Pamela J.; Jackson, Paul; Kingsley, Elizabeth Anne (2003), Prostate cancer methods and protocols, Humana Press, hlm. ... Clinical Cancer Research. 10 (13): 4489-97. doi:10.1158/1078-0432.CCR-03-0800 . PMID 15240541.. ...
"Bio-Protocol. 8 (7): e2791. doi:10.21769/bioprotoc.2791.. *^ "The diagnosis and management of anaphylaxis. Joint Task Force on ... The Journal of Allergy and Clinical Immunology. 101 (6 Pt 2): S465-528. 1998. doi:10.1016/S0091-6749(18)30566-9. PMID 9673591. ...
a b Richmond, T. S. (May 1997). "Cerebral Resuscitation after Global Brain Ischemia", AACN Clinical Issues 8 (2). Retrieved on ... "The Maryland Medical Protocols for Emergency Medical Services Providers" (PDF).. (1.00 MiB). Maryland Institute for Emergency ... The severity of a neonatal hypoxic-ischaemic brain injury may be assessed using Sarnat staging, which is based on clinical ... Focal cerebral ischemia constitutes a large majority of the clinical cases in stroke pathology with the infarct usually ...
Pawan JL (1959). "Rabies in the vampire bat of Trinidad, with special reference to the clinical course and the latency of ... "Milwaukee protocol") କୁହାଗଲା । ଏହି ହାଇପୋଥେସିସ୍ ଅନୁସାରେ ଜଳାତଙ୍କ ଭୁତାଣୁର ମସ୍ତିଷ୍କ ଉପରେ ସ୍ୱଳ୍ପ କାଳୀନ ନଷ୍ଟକାରୀ ପ୍ରଭାବ ରହେ । ଏଣୁ ...
... clinical endpoint - clinical latency - clinical practice guidelines - clinical trial - clinicaltrials.gov - cloning - CMS - CMV ... protocol - protozoa - provirus - pruritus - pseudo-Cushing's syndrome - pseudovirion - PUBMED - pulmonary - purified protein ... Community Programs for Clinical Research on AIDS (CPCRA) - community-based clinical trial (CBCT) - community-based organization ... Adult AIDS Clinical Trials Group (AACTG) - adverse drug reaction - aerosolized - AETC - agammaglobulinemia - Agency for ...
clinical sciences. *Nature Reviews Cardiology. *Nature Reviews Clinical Oncology. *Nature Reviews Disease Primers ... Nature Protocols. *Nature Structural & Molecular Biology. *Nature Sustainability. Nature Reviews. life sciences. *Nature ...
"Journal of Clinical Anesthesia. 21 (4): 253-7. doi:10.1016/j.jclinane.2008.08.019. PMC 2745934. PMID 19502033.. ... Protocols vary depending on local standard procedures and the extremity being operated on. A vast majority of practitioners ... Improved protocols, including adherence to standardized practice, may also help ameliorate the chance and the effect of ... The safety and effectiveness of IVRA is well established in clinical literature. However, cardiotoxic local anesthetic agents ...
This volume details reviews and protocols on the development and analysis of both cellular and animal-based pre-clinical models ... Pre-Clinical Models. Book Subtitle. Techniques and Protocols. Editors. * Paul C. Guest ... Authoritative and cutting-edge, Pre-Clinical Models: Techniques and Protocols aims to provide methods that describe the context ... This volume details reviews and protocols on the development and analysis of both cellular and animal-based pre-clinical models ...
Standardised Protocols Would Greatly Enhance Clinical And Research Potential Of BTMs. by Sam Savage ... He also noted that standardised protocols would greatly increase the clinical and research potential of BTMs, with improved ... In clinical practice, BTMs are used to monitor osteoporosis treatment. BTMs generally show large and rapid responses to the ... IOF and IFCC experts recommend international reference standards for use of bone turnover markers in clinical studies ...
Posting of these protocols does not constitute endorsement of any specific protocol. We believe that each institution should ... Key Points Successful implementation of protocols requires: Buy-in from key stakeholders (critical care physicians, house staff ... consult with diabetes experts to select and implement insulin protocols. ... AACE Clinical Case Reports *Endocrine Practice - Journal *EmPower Magazine - For Patients *Advertising Opportunities *Clinical ...
Clinical Rescue Protocol - 2. The safety and scientific validity of this study is the responsibility of the study sponsor and ... Treatment effectiveness score as an outcome measure in clinical trials. NIDA Res Monogr. 1997;175:208-20. Review. ... and to determine if blood levels of methadone or buprenorphine correlate with clinical response. ...
Home » Policy & Compliance » Clinical Trials » Clinical Trials Protocol Template. Clinical Trials Protocol Template. Applicants ... the NIH and FDA collaboratively developed a Phase 2/3 Clinical Trial Protocol Template and an electronic protocol-writing tool ... To facilitate the development of clinical trial protocols that require a Food and Drug Administration (FDA) Investigational New ... NIH and FDA Release Protocol Template for Phase 2 and 3 IND/IDE Clinical Trials ...
Screening for LID Clinical Studies Unit Healthy Volunteer Protocols. The safety and scientific validity of this study is the ... To accomplish this objective, up to 5000 participants will be enrolled in this protocol at the NIH Clinical Center clinic or ... The Laboratory of Infectious Diseases (LID) Clinical Studies Unit (CSU) enrolls healthy volunteers into clinical studies to ... NIH Clinical Center Detailed Web Page Publications: Anderson MJ, Heath RB. Cell mediated immunity in experimental influenza and ...
LINX Reflux Management System Clinical Study Protocol. The safety and scientific validity of this study is the responsibility ... Includes whether analysis was per protocol, intention to treat, or another method. Also provides relevant details such as ... Includes whether analysis was per protocol, intention to treat, or another method. Also provides relevant details such as ...
... new instruments and their related protocols enable the discovery or the improved characterization of bio-objects including ... nanovesicles within the 70-150nm diameter range that have recently aroused a great interest in the scientific and clinical ... Editorial: Tumor-Derived Extracellular Vesicles: Protocols, Models, and Clinical Evidence. Renaud Seigneuric1,2* and Carmen ... Tumor-Derived Extracellular Vesicles: Protocols, Models, and Clinical Evidence. The current frontiers in Oncology are at the ...
... limitation and the availability of extensive information contributes to the varying performance and high error rate of clinical ... Protocols need not be perfect. Several defensible and reasonable approaches are available for clinical problems. However, one ... Developing and implementing computerized protocols for standardization of clinical decisions Ann Intern Med. 2000 Mar 7;132(5): ... including use of the protocols themselves. Computerized protocols for mechanical ventilation and management of intravenous ...
Underreporting of clinical research is wasteful and can result in biased estimates of treatment effect or harm, leading to ... Methods We assembled a cohort of clinical studies approved 2000-2002 by the Research Ethics Committee of the University of ... Commercial funding was mentioned in 203 (48%) protocols and in 205 (49%) of the publications. In most published studies (339; ... Of the started studies, 576 (71%) were completed according to protocol, 128 (16%) discontinued and 42 (5%) are still ongoing; ...
... a team of researchers at Lawson Health Research Institute and Western University have developed a new clinical protocol called ... New clinical protocol after general surgery cuts opioid prescribing in half. Lawson Health Research Institute ... A study demonstrating the efficacy of their protocol is being presented at the American College of Surgeons Clinical Congress ... a team of researchers at Lawson Health Research Institute and Western University have developed a new clinical protocol called ...
WHO finalized an international review of a breakthrough clinical protocol for HIV infection in Ukraine that will put the ... Health topics Communicable diseases HIV/AIDS Ukraine develops modern and progressive clinical protocol for HIV treatment ... Ukraine develops modern and progressive clinical protocol for HIV treatment 13-12-2017. WHO finalized an international review ... of a breakthrough clinical protocol for HIV infection in Ukraine that will put the country on the fast track to scaling up HIV ...
... ... 2.3 This Protocol does not-. (a) provide any detailed guidance to healthcare providers on clinical risk management or the ... Enforcement of the Protocol and sanctions. 1.7 Where either party fails to comply with this Protocol, the court may impose ... b) the Pre-Action Protocol for Personal Injury Claims;. (c) the Pre-Action Protocol for Low Value Personal Injury Claims in ...
This unit presents description of four basic clinical paradigms for clinical fMRI of language cmprehension, eye movement ( ... This unit presents description of four basic clinical paradigms for clinical fMRI of language cmprehension, eye movement ( ... Comprehensive MRI protocol for stroke management: Tissue sodium concentration as a measure of tissue viability in a non‐human ... primate model and clinical studies. Radiology 139:26‐34. Thulborn, K.R., Martin, C., and Voyvodic, J. 2000. fMRI using a ...
Protocols/Clinical Trials Active Studies. Protocol # Protocol Name Status. ACTG A5239. A Pilot Study of Therapy with ...
It contains specific protocols for the treatment of chronic metal overexposure, all of which are evidence-based, aiding the ... All the protocols listed have been modified for the treatment of chronic metal intoxication, included are oral and intravenous ... The authors explain in simple terms how a chelating agent ́s bioavailability affects metal binding and how various protocols ... such as the Cutler Protocol affect the detoxification process, why DMPS binds mercury and which chelators are useful for the ...
... including unfavorable new clinical data and additional analyses of existing clinical data; the risk that clinical trial data ... Pfizer and Astellas Amend Clinical Research Protocols for Two Phase 3 Trials of Enzalutamide in Patients with Hormone-Sensitive ... amendments to protocols of the ARCHES and EMBARK clinical trials and the expected primary completion dates of those trials, ... Our goal is to build upon the body of clinical evidence for enzalutamide in an effort to help address the unmet needs of an ...
Part 1: Clinical Protocols Revised. 1. Current and Emerging Clinical Applications of the Auditory Steady-State Response (ASSR) ... Volume 1 primarily focuses on revised clinical protocols and provides information on new research to help guide decisions and ... 9. Clinical Applications of Frequency Following Response in Children and Adults. Milaine Dominici Sanfins, Stavros Hatzopoulos ... 8. Non-Conventional Clinical Applications of Otoacoustic Emissions: From Middle Ear Transfer to Cochlear Homeostasis to Access ...
Institutional Review Board Review of Protocol and Informed Consent Changes ... Implementing Protocol Changes Affecting Subjects Already Enrolled in a Clinical Trial Prior to Obtaining IRB Approval As noted ... IRB Review of Protocol and Informed Consent Changes for NCI/CTEP-Sponsored Clinical Trials. September 29, 2008 ... regarding the implementation of changes to protocols and informed consent documents for NCI/CTEP-sponsored clinical trials in a ...
Institutional Review Board Review of Protocol and Informed Consent Changes ... Implementing Protocol Changes Affecting Subjects Already Enrolled in a Clinical Trial Prior to Obtaining IRB Approval As noted ... IRB Review of Protocol and Informed Consent Changes for NCI/CTEP-Sponsored Clinical Trials. September 29, 2008 ... HHS Home > OHRP > IRB Review of Protocol & Informed Consent Changes for NCI/CTEP-Sponsored Clinical Trials ...
Effect of an Imaging Protocol on Clinical Outcomes Among Pediatric Patients With Appendicitis. Hugo A. Heij and Martin Offringa ... Effect of an Imaging Protocol on Clinical Outcomes Among Pediatric Patients With Appendicitis ... Effect of an Imaging Protocol on Clinical Outcomes Among Pediatric Patients With Appendicitis ... Effect of an Imaging Protocol on Clinical Outcomes Among Pediatric Patients With Appendicitis ...
ICON Further Enhances Clinical Trial Feasibility, Protocol Optimisation And Patient Recruitment Capabilities With TriNetX. ICON ... TriNetX enables researchers to find the right patients at the right sites for clinical trials. For more information, visit http ... It follows ICONs application of cognitive computing capabilities to clinical trial feasibility and patient recruitment. ICONs ... The company specialises in the strategic development, management and analysis of programs that support clinical development - ...
Protocol: Phytomedicine-AMARGOL®, Clinical Trial for Efficacy Proof on Therapeutics (AMARGOL). The safety and scientific ...
The aim of this paper was to present structured rehabilitation protocols in two different patient groups with upper extremity ... The rehabilitation protocol for group 1 included guided sEMG training to facilitate initial movements, to increase awareness of ... The rehabilitation protocol for group 1 included guided sEMG training to facilitate initial movements, to increase awareness of ... The aim of this paper was to present structured rehabilitation protocols in two different patient groups with upper extremity ...
... protocols,would,greatly,enhance,clinical,and,research,potential,of,BTMs,biological,biology news articles,biology news today, ... In clinical practice BTMs are used to monitor osteoporosis treatment....In its position paper* the Joint IOF-IFCC Bone Marker ... Standardized protocols would greatly enhance clinical and research potential of BTMs. ...An expert working group of the ... Methods for gene transfer in stem cells featured in Cold Spring Harbor Protocols. 9. Cold Spring Harbor Protocols features RNA ...
Clinical management. * The Globalization of Clinical Data in Medtech * Noteworthy Clinical Trends in Med Device to Watch in ... In a clinical trial, if they differ from the investigational plan and havent been approved by the Sponsor, theyre protocol ... Anticipating Tensions Between Clinical Care and Study Protocol 3 October, 2017 Laurie Meehan, Social Media Manager; Polaris ... Clinical Solution Overview Clinical Management Trial Master File Trial Software Laboratory QMS TMF Checklist ...
To determine whether our protocol could be used for the direct analysis of clinical samples, we carried out a study in which ... The utility of the protocol for the analysis of clinical samples was verified by analysis of aliquots taken directly from BacT/ ... The utility of our protocol for the direct analysis of clinical samples was tested using samples taken from positive BacT/Alert ... Although we evaluated a number of protocols for the isolation of template DNA, the CTAB protocol was the only one that yielded ...
Clinical Outcomes and Insulin Secretion After Islet Transplantation With the Edmonton Protocol. ... Clinical Outcomes and Insulin Secretion After Islet Transplantation With the Edmonton Protocol ... Clinical Outcomes and Insulin Secretion After Islet Transplantation With the Edmonton Protocol ... Clinical Outcomes and Insulin Secretion After Islet Transplantation With the Edmonton Protocol ...
Electroporation protocols : preclinical and clinical gene medicine. ?? : Li S. ???????? : Electroporation gene therapy, or gene ... Electroporation Protocols: Preclinical and Clinical Gene Medicine, Second Edition provides in-depth knowledge on the delivery ... readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. ...
Health topics Communicable diseases HIV/AIDS Publications Regional consultation on revision of clinical protocols "HIV/AIDS ... Regional consultation on revision of the clinical protocols HIV/AIDS treatment and care for the WHO European Region - http ... Regional consultation on revision of the clinical protocols HIV/AIDS treatment and care for the WHO European Region (Rus ... Regional consultation on revision of clinical protocols "HIV/AIDS treatment and care" for the WHO European Region. ...
  • To facilitate the development of clinical trial protocols that require a Food and Drug Administration (FDA) Investigational New Drug (IND) or Investigational Device Exemption (IDE) Application, the NIH and FDA collaboratively developed a Phase 2/3 Clinical Trial Protocol Template and an electronic protocol-writing tool to help investigators think through the scientific basis of their assumptions, minimize uncertainty in the interpretation of outcomes, and prevent loss of data. (nih.gov)
  • This study examines optic neuritis as a discrete central nervous system inflammatory event with measurable structural and clinical outcomes allowing the time-efficient (6 month) assessment of neuroprotective therapies. (bmj.com)
  • however these outcomes can be ameliorated when patients receive standardized care according to a clinical trial. (aacrjournals.org)
  • In the context of modest effects from most available physical therapy treatments for FS, this CNS-focused approach may lead to improved clinical outcomes. (medworm.com)
  • There were no clinically important differences in outcomes between the two protocols. (bmj.com)
  • Nurse-driven, protocol-directed weaning from mechanical ventilation improves clinical outcomes and is well accepted by intensive care unit physicians. (freecme.com)
  • A prospective study design was used to compare retrospective data from a specific 6-month period of physician-directed weaning outcomes with patient outcomes during a 6-month prospective period of the nurse-driven ventilator weaning protocol. (freecme.com)
  • Main outcomes for comparison included duration of mechanical ventilation (days), ICU length of stay, ventilator-associated pneumonia (VAP) rates, hospital mortality, and physician attitudes toward the nurse-managed protocol. (freecme.com)
  • The article by Danckers and colleagues reports on an innovative protocol that utilized the expertise of the ICU nursing staff to realize positive clinical outcomes for patients weaning from mechanical ventilatory support. (freecme.com)
  • Efficacy will be assessed by comparing clinical outcomes (death or hospitalization), disease severity using the 8-category NIAID COVID ordinal scale, supplemental oxygen use, and progression of COVID‑19 between patients receiving standard-of-care plus Bucillamine (high dose and/or low dose) and patients receiving standard-of-care plus placebo. (cbj.ca)
  • Combining these approaches allows the companies to address customer nuances related to trial protocols, capturing and analyzing clinical trial data faster and more efficiently with the goal of accelerating product time-to-market. (benzinga.com)
  • The Laboratory of Infectious Diseases (LID) Clinical Studies Unit (CSU) enrolls healthy volunteers into clinical studies to study infectious diseases. (clinicaltrials.gov)
  • While initially the protocol was designed to screen participants for influenza challenge studies, we have expanded our scope of research to include emerging and re-emerging infectious diseases.The primary goal of this study is to collect and store serum and RNA samples and obtain clinical and laboratory data from volunteers to determine in advance if they are potentially eligible to participate in future clinical studies. (clinicaltrials.gov)
  • Researchers blur the distinction themselves when they conduct procedures that are consistent with clinical care but deviate from the protocol. (mastercontrol.com)
  • All studies were open-labelled or single blinded and the final decision to administer or withhold antibiotic was left to the responsible clinician, who could deviate from the protocol. (bmj.com)
  • Protocols in Biochemistry and Clinical Biochemistry offers clear, applied instruction to fundamental biochemistry methods and protocols, from buffer preparation to nucleic acid purification, protein, lipid, carbohydrate, and enzyme testing, and clinical testing of vitamins, glucose and cholesterol levels, among other diagnostics. (researchandmarkets.com)
  • Treatment effectiveness score as an outcome measure in clinical trials. (clinicaltrials.gov)
  • This Protocol encourages a cards-on-the-table approach when something has gone wrong with a claimant's treatment or the claimant is dissatisfied with that treatment and/or the outcome. (justice.gov.uk)
  • Some studies showed that children with myeloid-positive ALL had a poorer clinical outcome compared with those of myeloid-negative ALL patients [ 10 , 18 , 19 ]. (hindawi.com)
  • Taken one step further, risk is minimized by helping ensure patient safety and outcome through proper application of appropriate standards of care (effective protocols) and good clinical judgment (effective training) by competent clinicians (effective hiring) using safe equipment (effective fleet and equipment maintenance). (emergencydispatch.org)
  • In the original protocol, the primary outcome measure is a dichotomized score on the modified Rankin Scale (mRS) [ 2 ] assessed at 3 months from onset of symptoms, with good functional outcome defined as a score of 0-2 and poor functional outcome as a score of 3-death. (pubmedcentralcanada.ca)
  • Furthermore, high-quality evidence comparing the clinical outcome of transalveolar sinus floor elevation with osteotome and modified sinus floor elevation with crestal non-cutting drills is limited. (springer.com)
  • More importantly, it identifies research priorities and recommends that specific markers be used as reference analytes for BTMs in clinical and observational studies. (redorbit.com)
  • It recommends that specific markers of bone formation (s-PINP) and of bone resorption (s-CTX) be used as reference analytes for bone turnover markers in clinical and observational studies. (redorbit.com)
  • Professor John Kanis, IOF President, urged the adoption of the reference standards by the scientific community, "Without precluding the use of other BTMs, the adoption of these reference standards would facilitate comparison between studies and allow data from different studies to be pooled in order to facilitate their incorporation into routine clinical practice. (redorbit.com)
  • Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. (clinicaltrials.gov)
  • The LID CSU performs clinical studies to learn about these viral infections and assist in the development of vaccines and treatments for the infections. (clinicaltrials.gov)
  • These clinical studies include influenza 'challenge studies' as well as natural history studies and phase I trials involving vaccines for viruses carried by mosquitos such as Zika or Dengue virus. (clinicaltrials.gov)
  • Previous human challenge studies have addressed some aspects of the natural history by evaluating the timing of viral replication, shedding, clinical symptoms, and innate and adaptive immune responses. (clinicaltrials.gov)
  • To accomplish this objective, up to 5000 participants will be enrolled in this protocol at the NIH Clinical Center clinic or day hospital in order to maintain a pool of participants who have been evaluated and can be screened for future LID Clinical Studies protocols. (clinicaltrials.gov)
  • Computerized protocols for mechanical ventilation and management of intravenous fluid and hemodynamic factors in patients with the acute respiratory distress syndrome provide case studies for this discussion. (nih.gov)
  • Clinical trials / research studies gives a clinician many answers to questions from the point of prevention, detection, diagnosis, control and treatment of illness or a condition such as cancer. (medindia.net)
  • Comprehensive MRI protocol for stroke management: Tissue sodium concentration as a measure of tissue viability in a non‐human primate model and clinical studies. (currentprotocols.com)
  • Seizure occurred in 0.4% of patients receiving XTANDI in clinical studies. (prnewswire.com)
  • Apparent dramatic reductions were achieved in both parameters by performing imaging studies in all patients with equivocal clinical findings. (aappublications.org)
  • The company specialises in the strategic development, management and analysis of programs that support clinical development - from compound selection to Phase I-IV clinical studies. (thestreet.com)
  • Clinical protocols for osteopathic manipulative treatment (OMT) procedures have been used in "technique" studies to examine the effects of specific procedures. (jaoa.org)
  • In my opinion, in technique studies based on protocols for OMT procedures, manipulations are not delivered in a manner consistent with osteopathic principles, and there may be unforeseen consequences of such research-whether findings for the procedures are positive or negative. (jaoa.org)
  • This TUViD-VM protocol can be used in metagenomic and virome studies to increase the likelihood of detecting viruses from any biological source. (cdc.gov)
  • The discrepancies between studies may be related to the use of different treatment protocols [ 20 ], different populations, as well as different definition criteria of myeloid-positive ALL, which are summarized in Table 1 . (hindawi.com)
  • Few studies to date have evaluated the effectiveness of different treatment protocols for acute hamstring injuries in athletes. (bmj.com)
  • A majority of previous studies on weaning protocols have examined respiratory therapists taking responsibility or ICU physicians directing weaning trials. (freecme.com)
  • In addition to spiral plates for clinical studies, we also use pour plates and filtration membranes in our in vitro studies. (selectscience.net)
  • Scientific Rationale of Bucillamine for COVID-19 Preclinical and clinical studies have demonstrated that reactive oxygen species contribute to the destruction and programmed cell death of pulmonary epithelial cells.1 N-acetyl-cysteine (NAC) has been shown to significantly attenuate clinical symptoms in respiratory viral infections in animals and humans, primarily via donation of thiols to increase antioxidant activity of cellular glutathione2,3,4,5. (cbj.ca)
  • Recent clinical studies have evaluated the efficacy electric stimulation for treating OAB [ 13 ] However, a randomized controlled trial (RCT) for validation of the comparative efficacy and safety of acupuncture with electric stimulation as concurrent treatment has not yet been undertaken. (springer.com)
  • The trial, whose protocol was designed with Hadassah, is scheduled to begin at the hospital toward the end of 2017, with the exact time frame depending on completion of the pre-clinical safety studies and necessary ethical approval. (hadassah.org)
  • In clinical practice, BTMs are used to monitor osteoporosis treatment. (redorbit.com)
  • Clinical endocrinologists worldwide rely on Endocrine Practice, the official journal of the American Association of Clinical Endocrinologists (AACE), to keep them on the leading edge of treatment of patients with endocrine diseases. (aace.com)
  • Members of AACE are physicians with special education, training and interest in the practice of clinical endocrinology. (aace.com)
  • Variation in clinical practice is due in part to clinicians' poor compliance with guidelines and recommended therapies. (nih.gov)
  • It is not likely to be concerned with minor or technical shortcomings (see paragraph 4.3 to 4.5 of the Practice Direction on Pre-Action Conduct and Protocols). (justice.gov.uk)
  • Protocol trumps practice. (mastercontrol.com)
  • When deciding whether or not to conduct a particular study, a PI needs to verify that the protocol is aligned with practice norms. (mastercontrol.com)
  • This protocol will provide greater support to their practice and to contribute to the early detection of precursor lesions and consequent decrease of the incidence of cervical cancer, as well as promote a better quality of care to clients. (scielo.br)
  • A review of blood pressure measurement protocols among hypertension trials: implications for "evidence-based" clinical practice. (g-i-n.net)
  • First, it may not correspond with everyday clinical practice. (pubmedcentralcanada.ca)
  • Introduction 24-hour ambulatory blood pressure monitoring (ABPM) is the gold standard diagnostic method for hypertension, but has some shortcomings in clinical practice while clinical settings often lack sufficient devices to accommodate all patients with suspected hypertension. (upc.edu)
  • Using data from eight Community Care Access Centres (CCACs) in Ontario, we demonstrate that an automatic, data-driven, machine learning algorithm such as the K nearest neighbors (KNN) algorithm can predict rehabil itation potential more effectively than the current Clini cal Assessment Protocol (CAP). (actapress.com)
  • Full clinical assessment including speculum examination and microbiological assessment for infection with gonorrhoea, chlamydia, candida, trichomonas, and bacterial vaginosis was performed on all women. (bmj.com)
  • Follow up assessment of clinical and microbiological response was performed 1-2 weeks later. (bmj.com)
  • Electroporation Protocols: Preclinical and Clinical Gene Medicine, Second Edition provides in-depth knowledge on the delivery of naked DNA and small-interfering RNA (siRNA) to the targeted cells, tissues, and animals for prevention and treatment of disease. (mexmat.ru)
  • Ibudilast's anti-neuroinflammatory and neuroprotective actions have been demonstrated in preclinical and clinical study results and provide the rationale for its potential therapeutic utility in neurodegenerative diseases (e.g., progressive MS and ALS), substance abuse/addiction and chronic neuropathic pain. (cnbc.com)
  • Any GCP course worth its registration fee will discuss the distinction between standard of care and the study protocol. (mastercontrol.com)
  • The study protocol refers to the 'recipe' used to conduct a study des. (bio-medicine.org)
  • The study protocol refers to the 'recipe' used to conduct a study, describes what will be done during the study, how this will be done and why it is being done. (bio-medicine.org)
  • The SPA request includes the proposed Phase III study protocol, statistical analysis plans and briefing materials along with specific questions from CereSpir to facilitate a meaningful dialogue with the FDA on the proposed study design. (cnbc.com)
  • The clinical experience of human immunodeficiency virus (HIV) + patients treated with oral atovaquone for acute Pneumocytstis carinii pneumonia (PCP) under a Treatment Investigational New Drug (IND) protocol (mild or moderate PCP) and an Open-Label Study protocol (severe PCP) was evaluated. (rti.org)
  • Transcutaneous vagus nerve stimulation for the treatment of depression: a study protocol for a double blinded randomized clinical trial. (nih.gov)
  • With the IRB approval of the Phase 3 study protocol for COVID-19, we can recruit U.S. clinical sites efficiently, allowing us to move forward with providing Bucillamine to patients under our IND that was approved by the FDA last month," said Michael Frank, Revive's Chief Executive Officer. (cbj.ca)
  • The companies now anticipate the primary completion date for the ARCHES clinical trial to be in late 2018. (prnewswire.com)
  • NEW YORK and TOKYO, Aug. 22, 2018 /PRNewswire/ -- Pfizer Inc. (NYSE: PFE) and Astellas Pharma Inc. (TSE: 4503, President and CEO: Kenji Yasukawa, Ph.D., "Astellas") today announced amendments to the protocols for two registrational Phase 3 trials, ARCHES and EMBARK, designed to evaluate the safety and efficacy of XTANDI ® (enzalutamide) in men with hormone-sensitive prostate cancer (HSPC). (astellas.com)
  • A study demonstrating the efficacy of their protocol is being presented at the American College of Surgeons Clinical Congress in Boston, Massachusetts on October 24. (eurekalert.org)
  • Kenji Yasukawa , Ph.D., 'Astellas') today announced amendments to the protocols for two registrational Phase 3 trials, ARCHES and EMBARK, designed to evaluate the safety and efficacy of XTANDI ® (enzalutamide) in men with hormone-sensitive prostate cancer (HSPC). (prnewswire.com)
  • The Phase 2 clinical program generated preliminary safety and efficacy data in approximately 100 people, half of whom received CSP-1103 for up to 2 years. (cnbc.com)
  • The present study has led to the development of a dynamic pre-clinical testing protocol to quantitatively assess the efficacy of disc replacement devices. (bl.uk)
  • The endorsed technical documents are aimed at empowering and developing a critical mass of technical capacity of scientists in Africa to conduct proper clinical trials to ensure quality, safety and efficacy of traditional medicines in line with international standards. (who.int)
  • Phase III clinical trials are pivotal in fully assessing the safety and efficacy of a new medical product. (who.int)
  • Amiloride Clinical Trial In Optic Neuritis (ACTION) will utilise a multimodal approach to assess the neuroprotective efficacy of amiloride in acute ON. (bmj.com)
  • A recent paper ( doi:10.1038/sj.tpj.6500489 ) expands on the ethics of race-related research protocols in the context of the efficacy of Bidil, a cardiovascular drug, that works best in self-identified African-Americans. (wordpress.com)
  • This course served as a useful introduction to the issues of translating clinical trials. (proz.com)
  • Thank you for sharing this Journal of Clinical Microbiology article. (asm.org)
  • Message Body (Your Name) thought you would be interested in this article in Journal of Clinical Microbiology. (asm.org)
  • He also noted that standardised protocols would greatly increase the clinical and research potential of BTMs, with improved value in patient management and other uses, such as prediction of the rate of bone loss, identification of secondary osteoporosis, prediction of response to therapy, and in improving treatment adherence. (redorbit.com)
  • This research topic aims at providing recent findings and reviews to contribute to the maturation of this emerging field with high clinical potential. (frontiersin.org)
  • Recognizing the role that opioid prescribing plays in the opioid crisis, a team of researchers at Lawson Health Research Institute and Western University have developed a new clinical protocol called STOP Narcotics. (eurekalert.org)
  • Clinical trials or research is done when there is some reason to believe that the treatment being studied may be valuable to the patient. (medindia.net)
  • Volume 1 primarily focuses on revised clinical protocols and provides information on new research to help guide decisions and criteria regarding diagnosis, management, and treatment of hearing-related issues. (routledge.com)
  • This is a research study to test the clinical procedure and not the FDA approved medical device. (clinicaltrials.gov)
  • This 3 year research study will examine the clinical effects of loading regimens on roughened surfaced implants. (clinicaltrials.gov)
  • ICON's ability to recruit patients is also strengthened through a wholly owned site network - PMG Research - with access to over 2 million active patient lives, as well as site partnerships with clinical research sites at healthcare systems and community physician practices all over the world. (thestreet.com)
  • TriNetX is the worldwide health research network of healthcare organizations, biopharmaceutical companies and contract research organizations used to enhance clinical trial design and accelerate patient recruitment. (thestreet.com)
  • Standardized protocols would greatly enhance clinical and research potenti. (bio-medicine.org)
  • Therapeutic misconception - a well-documented phenomenon in clinical research - occurs when a study participant "fails to appreciate the distinction between the imperatives of clinical research and of ordinary treatment. (mastercontrol.com)
  • This is where well-trained clinical research assistants (CRAs) come in. (mastercontrol.com)
  • SYNH ), the only fully integrated biopharmaceutical solutions organization, and Protocol First, Inc., a software solutions provider focused on accelerating clinical research, today announced a novel strategic partnership aimed at driving faster, more efficient clinical trials. (benzinga.com)
  • The collaboration responds to the increasing demand from biopharmaceutical customers for digital solutions that break down silos between Sites, Sponsors, CROs and functional areas to accelerate the collection and review of clinical trial research data. (benzinga.com)
  • This partnership with Protocol First further strengthens our Dynamic Assembly network and supports our strategy to bring creative solutions to research sites. (benzinga.com)
  • It is a harbinger of the transformation of clinical research to a digital model that ensures end-to-end data traceability in the most complex 'precision medicine' trials, while supporting remote and decentralized study execution," said Hugh P. Levaux, Ph.D., Founder and CEO for Protocol First. (benzinga.com)
  • This study is a collaborative effort between MediciNova, Inc. and Drs. Nazem Atassi and Haruhiko Banno, Principal Investigators at Massachusetts General Hospital's (MGH) Neurological Clinical Research Institute (NCRI) and Harvard Medical School to measure the effects of MN-166 on reducing brain microglial activation utilizing a biomarker in 15 subjects with ALS. (cnbc.com)
  • Feasibility data is analyzed, summarized and graphically presented in an executive summary document that provides supporting data and facts clearly, to assist the optimal development of your clinical research program. (worldwide.com)
  • There is a lack of clinical research and consensus regarding the effectiveness of various rehabilitation protocols for acute hamstring injuries in football. (bmj.com)
  • RESEARCH TRIANGLE PARK, NC --(Marketwired - December 18, 2014) - Today's strict regulatory environment necessitates that pharmaceutical companies adhere to clinical investigator fair market value (FMV) for trial-related compensation. (marketwired.com)
  • The Sunshine Act has changed how companies and trial managers pay clinical investigators," said Ryan McGuire, Head of Research at Cutting Edge Information. (marketwired.com)
  • To learn more about Cutting Edge Information's clinical investigator research and fair market value services, please visit http://cuttingedgeinfo.com/ . (marketwired.com)
  • A short, seven question, survey was distributed to all employees in the Section of Hematology/Oncology who were directly involved in clinical care or research. (aacrjournals.org)
  • Demonstrate and maintain knowledge of regulations, clinical research conduct, laws, guidelines and standards relating to department/trial(s). (americasjobexchange.com)
  • A literature and market research was performed to analyze the state-of-the-art and thereupon develop, integrate and validate an automated glucose measurement transmission protocol in an iterative process. (joanneum.at)
  • Findings from literature and market research guided towards the development of a standardized glucose measurementtransmission protocol using a middleware. (joanneum.at)
  • Synbiosis, a world-leading manufacturer of automated micro-biological systems, today announced its ProtoCOL automated colony counter is being successfully used by the Skin Research Centre (SRC) at the University of Leeds, one of Europe's leading dermatology centres, to rapidly test the effectiveness of new anti-microbial therapies to treat acne, dermatitis and other skin diseases. (selectscience.net)
  • Collette Lindley, Research Assistant at the SRC stated: "Our validated methods for clinical trials require a large throughput of growth media types and dilution replicates with up to 16 spiral plates for each subject for each study visit. (selectscience.net)
  • To accomplish this purpose, IRBs use a group process to review research protocols and related materials (e.g., informed consent documents and investigator brochures) to ensure the protection of the rights and welfare of human subjects of research. (cbj.ca)
  • Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields. (omicsonline.org)
  • If we want to improve the depressing health metrics for our indigenous population, it is worth debating the value of race-related basic medical research and clinical trials. (wordpress.com)
  • Ethics and dissemination The protocol has been authorised by the research ethics committee of the Hospital Clinic of Barcelona (Ref. HCB/2014/0615): protocol details and amendments will be recorded and reported to ClinicalTrials.com. (upc.edu)
  • With these changes, the estimated primary completion date for the EMBARK clinical trial is mid-2020. (prnewswire.com)
  • As you know, on March 20, 2008 CTEP issued a memorandum to NCI/CTEP-sponsored cooperative groups explaining implementation of revised CTEP procedures for handling amendments to cooperative group protocols and enrollment of new subjects in these protocols in situations in which new or modified risk information is considered to represent no more than a minor alteration in the overall risk-benefit relationship for subjects. (hhs.gov)
  • whether suspensions of new subject enrollment by CTEP pending IRB approval of protocol and informed consent document changes need to be reported to OHRP. (hhs.gov)
  • We hypothesize that a provider-directed intervention will increase rates of cancer clinical trial enrollment amongst African-Americans. (aacrjournals.org)
  • Failure of bedside hospital clinical staff to follow established treatment protocols has been identified as a common factor in patients having an adverse event during their hospitalisation. (bmj.com)
  • This reasoning is the basis of an explicit method of decision support that allows the rigorous evaluation of interventions, including use of the protocols themselves. (nih.gov)
  • A fast and accurate data transmission from glucose meter to clinical decision support systems (CDSSs) is crucial for the management of type 2 diabetes mellitus since almost all therapeutic interventions are derived from glucose measurements. (joanneum.at)
  • Dr. Ken Leslie, scientist at Lawson, associate professor in the Department of Surgery at Schulich Medicine & Dentistry, and Chair/Chief of the Division of General Surgery at London Health Sciences Centre led the implementation of the new protocol. (eurekalert.org)
  • Implementation of a nurse-driven protocol for weaning patients resulted in shortened duration of mechanical ventilation, shorter ICU stays, and a higher rate of successful weaning, with ICU physicians reporting a generally positive attitude toward nurses being responsible for protocol-directed weaning. (freecme.com)
  • The nurses participated in protocol training and education sessions prior to implementation of the protocol, with a 1-month pilot period to gain familiarity with the protocol and to standardize communication with physicians. (freecme.com)
  • We are very pleased that this important regulatory step is now completed as we can continue clinical evaluation of MN-166 in the treatment of ALS. (cnbc.com)
  • Evaluation of two clinical protocols for the management of women with vaginal discharge in southern Thailand. (bmj.com)
  • Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. (springer.com)
  • No protocol or proposed program is recommended without full knowledge of the logistical and financial implications in addition to the clinical and regulatory implications. (worldwide.com)
  • Implications for clinical decision-making and computerized health information sys tems are discussed. (actapress.com)
  • Paracetamol (Acetaminophen) In Stroke (PAIS) is a randomized, double-blind clinical trial, comparing high-dose acetaminophen with placebo in 2500 patients. (pubmedcentralcanada.ca)
  • The Paracetamol (Acetaminophen) In Stroke (PAIS) study is a phase III multicenter, double blind, randomized, placebo-controlled clinical trial of high-dose acetaminophen in patients with acute stroke. (pubmedcentralcanada.ca)
  • As part of our mission to eliminate cancer, MD Anderson researchers conduct hundreds of clinical trials to test new treatments for both common and rare cancers. (mdanderson.org)
  • 1.4 This Protocol is now regarded by the courts as setting the standard of normal reasonable pre-action conduct for the resolution of clinical disputes. (justice.gov.uk)
  • 1.5.1 This Protocol sets out the conduct that prospective parties would normally be expected to follow prior to the commencement of any proceedings. (justice.gov.uk)
  • Advise sites on protocol conduct, interpretation of protocols and ensures resolution of issues as applicable per department/trial. (americasjobexchange.com)
  • This discussion belongs to ProZ.com training » "The Anatomy of a Clinical Trial Protocol: Important Concepts and Essential Terminology for Accurate Translation" . (proz.com)
  • Now, however, companies evaluate a variety of factors including industry benchmarks, historic payment data and trial protocol details. (marketwired.com)
  • The push for greater transparency and compensation justification, however, has led to a payment process where clinical investigator fair market value is determined more from trial protocol than from investigator qualification. (marketwired.com)
  • Working independently and under general supervision, the Clinical Trial Protocol Coordinator will support their department/trial(s) in the administrative day to day project activities of TIMI trials (both nationally and internationally) following good clinical practices, regulatory requirements and sponsors/TIMI standards to ensure compliance for the TIMI Study Group. (americasjobexchange.com)
  • A central goal of The Academy of Breastfeeding Medicine is the development of clinical protocols for managing common medical problems that may impact breastfeeding success. (nih.gov)
  • In addition, the results of this double-blinded clinical trial will shed new light on our understanding of acupuncture point specificity, and development of methodologies in clinical trials of acupuncture treatment. (nih.gov)
  • We conducted two randomized, placebo-controlled clinical trials to study whether early treatment with acetaminophen reduces body temperature in patients with acute ischemic stroke confined to the carotid territory. (pubmedcentralcanada.ca)
  • We continually strive to design and implement clinical trials that bring innovations to people with the greatest need,' said Steven Benner , M.D., senior vice president and global therapeutic area head, Oncology Development, Astellas. (prnewswire.com)
  • In order to identify potential intervention strategies, we surveyed staff in the Section of Hematology/Oncology at the University of Chicago regarding clinical trial accrual. (aacrjournals.org)
  • Clinical pharmacology has changed many clinical systems, including anaesthesia delivery in both the hospital and ambulatory surgery settings. (termedia.pl)
  • It follows ICON's application of cognitive computing capabilities to clinical trial feasibility and patient recruitment . (thestreet.com)
  • Feasibility of the rehabilitation protocols for the two different patient populations was illustrated. (frontiersin.org)
  • Worldwide Clinical Trials is recognized for protocol and feasibility evaluations that are accurate, comprehensive, and insightful. (worldwide.com)
  • On April 7, 2008 CTEP issued its first Action Letter under the revised CTEP procedures to investigators conducting CTEP/NCI-sponsored clinical trials involving the use of lapatinib (IND 70252). (hhs.gov)
  • It also examines common milestone payments, the number of payments made to clinical investigators and ranges and averages of direct costs that investigators often pass through to sponsors. (marketwired.com)
  • In addition, the investigators were wise to survey the intensivists who staff this ICU on their perceptions of the nurse-managed weaning protocol since they ultimately gave the "green light" to proceed with extubation. (freecme.com)
  • Objective To characterise the clinical features of patients admitted to hospital with coronavirus disease 2019 (covid-19) in the United Kingdom during the growth phase of the first wave of this outbreak who were enrolled in the International Severe Acute Respiratory and emerging Infections Consortium (ISARIC) World Health Organization (WHO) Clinical Characterisation Protocol UK (CCP-UK) study, and to explore risk factors associated with mortality in hospital. (bmj.com)
  • Objective To compare the effectiveness of two rehabilitation protocols after acute hamstring injury in Swedish elite football players by evaluating time needed to return to full participation in football team-training and availability for match selection. (bmj.com)
  • Methods Seventy-five football players with an acute hamstring injury, verified by MRI, were randomly assigned to one of two rehabilitation protocols. (bmj.com)
  • Two randomized double-blind clinical trials in patients with acute ischemic stroke have shown that treatment with a daily dose of 6 g acetaminophen (paracetamol) results in a small but rapid and potentially worthwhile reduction of 0.3°C (95% CI: 0.1-0.5) in body temperature. (pubmedcentralcanada.ca)
  • Results 98% provided two or more acute samples, but only 60% supplied clinical information. (bmj.com)
  • DESIGN: Alternate allocation of subjects to one of two management protocols. (bmj.com)
  • The National Task Force on Covid-19 has decided against including Itolizumab drug in clinical management protocols for treating the disease even though the DCGI has approved its 'restricted emergency use' in infected patients, official sources said. (business-standard.com)
  • A majority of the members of the task force opined that there was not enough evidence currently to get the drug included in the clinical management protocols for Covid-19,' said an official source. (business-standard.com)
  • Applicants conducting phase 2 or 3 clinical trials that require Investigational New Drug applications (IND) or Investigational Device Exemption (IDE) applications can use a NIH-FDA template with instructional and sample text to help write protocols. (nih.gov)
  • The tool provides a suggested format for phase 2 and 3 clinical trials funded by NIH that are being conducted under an FDA IND or IDE Application. (nih.gov)
  • Reasons for Premature Conclusion of Late Phase Clinical Trials: An Analysis of ClinicalTrials.gov Registered Phase III Trials. (medindia.net)
  • Revisions were also made to the protocol for EMBARK, a randomized Phase 3 study of enzalutamide plus leuprolide, enzalutamide monotherapy, and leuprolide alone in men with high-risk non-metastatic HSPC. (prnewswire.com)
  • The proposed Phase 3 clinical trial is designed as an adequate and well controlled, double-blind, adaptive design, placebo-controlled multinational study of CSP-1103 administered to subjects with MCI due to AD who have biomarker evidence supporting this condition. (cnbc.com)
  • About the Phase 3 Confirmatory Clinical Study The Phase 3 confirmatory clinical study titled, "A Multi-Center, Randomized, Double-Blind, Placebo-Controlled Study of Bucillamine in Patients with Mild-Moderate COVID-19", will enroll up to 1,000 patients that will be randomized 1:1:1 to receive Bucillamine 100 mg three times a day ("TID"), Bucillamine 200 mg TID or placebo TID for up to 14 days. (cbj.ca)
  • Kadimastem, an Israeli biotechnology company, will be conducting a Phase I/IIA clinical trial with its stem cell product, AstroRx®, derived from Hadassah's clinical grade human embryonic stem cell (hESC) lines. (hadassah.org)
  • In this study, we quantifiably and extensively compared classical and modern experimental approaches for virus purification and enrichment to finalize a protocol for unbiased detection of emerging viruses directly from organ tissues (tissue-based unbiased virus detection for viral metagenomics [TUViD-VM]) for an increased signal-to-noise ratio (ratio of virus genome to host genome) in virus detection. (cdc.gov)
  • Schematic description of tissue-based universal virus detection for viral metagenomics protocol. (cdc.gov)
  • Based on the preceding discussion, the most important considerations with respect to the diagnosis of staphylococcal infections are (i) identification of staphylococci in clinical specimens, (ii) differentiation of S. aureus from the less-pathogenic CNS, and (iii) determination of whether isolates of either group are resistant to oxacillin. (asm.org)
  • However, for clinical specimens, such as blood, other fluids, or infected organ tissues, successful detection of viruses is less likely because virus-to-host genome ratios are insufficient ( 3 - 6 ). (cdc.gov)
  • Analysis of bronchoalveolar lavage specimens from immunocompromised patients with a protocol applicable in the microbiology laboratory. (asm.org)
  • We improved the capacity of clinical-grade monocyte-derived dendritic cells to elaborate IL-12 with special regard of their state of maturation, different maturation stimuli and its regulation by TH1/TH2-influencing cytokines. (egms.de)
  • All investigated clinical-grade protocols for maturation of monocyte-derived DC appeared able to provide the phenotypic characteristics necessary to initiate DC maturation. (egms.de)
  • It is important to keep in mind that these algorithms have not been directly compared in clinical trials. (aace.com)
  • Moreover, it examines clinical measurement devices and reagents as utilized in hospitals, clinics, doctor's offices and at-home care locations. (prnewswire.co.uk)
  • Aim was to develop a prototype of an automated glucose measurement transmission protocol based on the Continua DesignGuidelines and to embed the protocol into a CDSS used by healthcare professionals. (joanneum.at)
  • 3 American Osteopathic Association (AOA) protocols for the use of OMT state that the "diagnosis must be specific. (jaoa.org)
  • 2) To determine clinical and simple laboratory indicators for diagnosis of patients with vaginal discharge in the local setting. (bmj.com)
  • Objectives To validate the efficiency of the application of a diagnostic protocol based on the patterns of presentation of uveitis to establish the diagnosis. (bmj.com)
  • Inclusion criteria are a clinical diagnosis of hemorrhagic or ischemic stroke and the possibility to start treatment within 12 hours from onset of symptoms. (pubmedcentralcanada.ca)
  • An exploratory study of the follow-up care needs of patients treated for colorectal cancer," Journal of Clinical Nursing , vol. 19, pp. 3291-3300, 2010. (hindawi.com)
  • An expert working group of the International Osteoporosis Foundation (IOF) and the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) has released a new position paper which reviews the evidence of bone turnover markers (BTMs) in fracture risk prediction and monitoring of osteoporosis therapy. (redorbit.com)
  • OBJECTIVES: (1) To compare the effectiveness of two clinical protocols for the management of vaginal discharge in the situations where no laboratory facilities are available but speculum examination is possible and where basic laboratory facilities are available. (bmj.com)
  • METHODS: Subjects were alternately allocated management according to one of two protocols: one without (group A) and one with (group B) immediate access to results of basic laboratory tests. (bmj.com)
  • Simple clinical indicators for candidiasis, bacterial vaginosis, or trichomonas as in protocol A are sufficiently sensitive and specific for use in situations with no laboratory support. (bmj.com)
  • Conclusion Procalcitonin-based protocols to guide the administration of antibiotics in patients presenting with AECOPD appear safe and clinically effective. (bmj.com)
  • In conclusion, our optimized assay is suitable to quantify telomerase activity in clinical tissue samples without interference by PCR inhibitors. (omicsonline.org)
  • TriNetX offers robust query and analytics tools that enable real-time analyses of patient populations which are helping our customers design better protocols, select the right sites and recruit patients faster. (thestreet.com)
  • Your human subjects study may meet the NIH definition of a clinical trial. (nih.gov)
  • The primary objective of the study will be to evaluate the effects of CSP-1103 compared to placebo on clinical decline in subjects with MCI due to AD and who are also positive for amyloid β (Aβ) biomarker. (cnbc.com)
  • The plate counts generated are then used to determine which treatments are the most effective at reducing the number of microorganisms associated with diseases on the skin of clinical trial subjects. (selectscience.net)
  • The purpose of this study was to compare the usual method of physician-directed weaning from mechanical ventilation to a weaning protocol directed and managed by bedside ICU nurses. (freecme.com)
  • The purpose of this study is to detect increasing medication dose results in heroin cessation for patients still using, to determine if decreasing medication dose in patients unable to tolerate medication dose increases retention, and to determine if blood levels of methadone or buprenorphine correlate with clinical response. (clinicaltrials.gov)
  • Now a second clinical study will assess whether this reduced exposure is maintained over the longer term, and also whether longer term exposure reduction results in detectable changes in biological effect. (bio-medicine.org)
  • Total disc replacement has emerged as a viable treatment but the complexity of the spine is reflected in the clinical results, which trail far behind the success of hip and knee arthroplasty. (bl.uk)
  • Results Time to return was significantly shorter for the players in the L-protocol, mean 28 days (1SD±15, range 8-58 days), compared with the C-protocol, mean 51 days (1SD±21, range 12-94 days). (bmj.com)
  • The results of the study show a discrepancy between the absorbed dose-to-water determined according to TG-21 and TG-51 protocols of about 1.4% and 1.7% for 6 and 18 MV photon beams, respectively. (oregonstate.edu)
  • We divided the results into four categories, patient barriers, provider barriers, protocol barriers and health system barriers. (aacrjournals.org)
  • The survey queried respondents about their opinions on the current impediments to and facilitators of cancer clinical trial accrual at the University of Chicago as well as asking for their opinions on ways to improve the process. (aacrjournals.org)
  • Computerized protocols used to deliver decision support can be configured to contain much more detail than textual guidelines or paper-based flow diagrams. (nih.gov)
  • The recommendations will be taken into account during the WHO Regional Office for Europe-initiated revision of its 2007 HIV/AIDS clinical guidelines for the WHO European Region, based on revised global WHO recommendations on ART for adults and adolescents, ART for infants and children, use of ARVs for treatment of HIV-infected pregnant women and infants born to them. (who.int)
  • These protocols serve only as guidelines for the care of breastfeeding mothers and infants and do not delineate an exclusive course of treatment or serve as standards of medical care. (nih.gov)
  • Conclusions Good compliance with UK guidelines for tryptase measurements is achievable in this long-term cohort, but obtaining clinical details at referral remains a challenge. (bmj.com)
  • The aim of this paper was to present structured rehabilitation protocols in two different patient groups with upper extremity nerve injuries using sEMG biofeedback. (frontiersin.org)
  • The rehabilitation protocol for group 1 included guided sEMG training to facilitate initial movements, to increase awareness of the new target muscle, and later, to facilitate separation of muscular activities. (frontiersin.org)
  • Study design Prospective randomised comparison of two rehabilitation protocols. (bmj.com)
  • Conclusions A rehabilitation protocol emphasising lengthening type of exercises is more effective than a protocol containing conventional exercises in promoting time to return in Swedish elite football. (bmj.com)
  • The primary objective of all rehabilitation protocols is to return the player as soon as possible to the prior level of performance with a minimal risk of injury recurrence. (bmj.com)
  • When we looked at the data from this new protocol, we saw that the patient's pain-control was just as good with this pathway, without a huge prescription for narcotics. (eurekalert.org)
  • Investigation of the Influencing Factors on the Incidence of Vertebral Fracture: A Meta-analysis Based on Placebo Data of Randomized Clinical Trials. (medindia.net)
  • Each data point in the TriNetX system can be traced to healthcare organisations who have the ability to identify individual patients, enabling ICON to develop virtual patient cohorts that can be found in real-world clinical trial settings. (thestreet.com)
  • The partnership is expected to optimize data integration with Electronic Health Record Systems and support Remote Source Data Review, further extending a multi-year, pre-existing relationship between Syneos Health and Protocol First. (benzinga.com)
  • The enhanced collaboration furthers the ability of Syneos Health to combine Protocol First's proprietary software solutions that integrate data from leading EHR systems into electronic data capture (EDC) with operational insights from Syneos Health Dynamic Assembly ® network - an open ecosystem of best-of-breed data and technology collaborators - to deliver fit-for-purpose customer solutions. (benzinga.com)
  • How are mutational data helping inform clinical prognosis and treatment protocol? (ajmc.com)
  • Additionally, the spine simulator and testing protocol would provide valuable data during the design stage of new total disc replacements, aiding the development of the next generation of artificial discs. (bl.uk)
  • These two separate cohorts are included in one single protocol to enable patient data from these two groups to be entered into a common database, as the current prognostic classifications determining treatment may evolve further with subsequent more detailed molecular analysis of the tumours. (centerwatch.com)
  • Also, there are some differences between the beam quality specifiers and data proposed by the two protocols. (oregonstate.edu)
  • The TG-51 protocol allows the determination of a more accurate absorbed dose in a ⁶⁰Co beam than the TG-21 protocol since it uses an absorbed dose-to-water calibration factor directly measured, while the exposure based dosimetry system is dependent on external physical data which are not measured in clinics. (oregonstate.edu)
  • Our clinical trial data is also subject to audit by regulatory authorities at any time. (selectscience.net)
  • For the final step, four judges were selected to evaluate the clinical protocol according to AGREE 2. (scielo.br)
  • CONCLUSIONS: Both protocols were equally effective in managing women with abnormal vaginal discharge. (bmj.com)
  • Conclusions Despite an organisational commitment to the RRS, clinical staff act on local cultural rules within the clinical environment that are usually not explicit. (bmj.com)
  • African-Americans are underrepresented amongst cancer clinical trial participants, despite evidence from our institution that African-Americans were more than twice as likely as Caucasians to enroll in a cancer clinical trial when offered. (aacrjournals.org)
  • It contains specific protocols for the treatment of chronic metal overexposure, all of which are evidence-based, aiding the inexperienced and the experienced therapist in selecting the optimal chelating agent for the metal(s) in question. (google.com)
  • Our goal is to build upon the body of clinical evidence for enzalutamide in an effort to help address the unmet needs of an even broader spectrum of prostate cancer patients. (prnewswire.com)
  • Considering that screening actions are the main source of evidence for detection of cervical cancer precursor lesions, it is necessary to build a protocol to be followed by nursing professionals during gynecological consultations. (scielo.br)
  • Authoritative and cutting-edge, Pre-Clinical Models: Techniques and Protocols aims to provide methods that describe the context of specific disease or therapeutic areas. (springer.com)
  • Join the world's largest organization that represents clinical endocrinologists, with over 6,500 members in the United States and 97 other countries. (aace.com)
  • A common protocol structure and organization facilitates protocol review by oversight entities. (nih.gov)
  • Never developed in isolation, all our protocols are fully verified through the operational components of the organization. (worldwide.com)
  • We defined a clinical diagnostic protocol for the uveitis, based on the frequency of syndromes found in the literature in each clinical pattern of uveitis and the symptoms of the patients. (bmj.com)