Clinical Protocols: Precise and detailed plans for the study of a medical or biomedical problem and/or plans for a regimen of therapy.Genetic Therapy: Techniques and strategies which include the use of coding sequences and other conventional or radical means to transform or modify cells for the purpose of treating or reversing disease conditions.Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.Reproducibility of Results: The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.Magnetic Resonance Imaging: Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Leucovorin: The active metabolite of FOLIC ACID. Leucovorin is used principally as an antidote to FOLIC ACID ANTAGONISTS.Clinical Trials, Phase I as Topic: Works about studies performed to evaluate the safety of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques in healthy subjects and to determine the safe dosage range (if appropriate). These tests also are used to determine pharmacologic and pharmacokinetic properties (toxicity, metabolism, absorption, elimination, and preferred route of administration). They involve a small number of persons and usually last about 1 year. This concept includes phase I studies conducted both in the U.S. and in other countries.TexasRetrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.Adenocarcinoma: A malignant epithelial tumor with a glandular organization.Osteoporosis: Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis.Fractures, Bone: Breaks in bones.Bone Density: The amount of mineral per square centimeter of BONE. This is the definition used in clinical practice. Actual bone density would be expressed in grams per milliliter. It is most frequently measured by X-RAY ABSORPTIOMETRY or TOMOGRAPHY, X RAY COMPUTED. Bone density is an important predictor for OSTEOPOROSIS.Osteoporotic Fractures: Breaks in bones resulting from low bone mass and microarchitectural deterioration characteristic of OSTEOPOROSIS.Chemistry, Clinical: The specialty of ANALYTIC CHEMISTRY applied to assays of physiologically important substances found in blood, urine, tissues, and other biological fluids for the purpose of aiding the physician in making a diagnosis or following therapy.Bone Remodeling: The continuous turnover of BONE MATRIX and mineral that involves first an increase in BONE RESORPTION (osteoclastic activity) and later, reactive BONE FORMATION (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium HOMEOSTASIS. An imbalance in the regulation of bone remodeling's two contrasting events, bone resorption and bone formation, results in many of the metabolic bone diseases, such as OSTEOPOROSIS.Osteoporosis, Postmenopausal: Metabolic disorder associated with fractures of the femoral neck, vertebrae, and distal forearm. It occurs commonly in women within 15-20 years after menopause, and is caused by factors associated with menopause including estrogen deficiency.Saccades: An abrupt voluntary shift in ocular fixation from one point to another, as occurs in reading.Visual Cortex: Area of the OCCIPITAL LOBE concerned with the processing of visual information relayed via VISUAL PATHWAYS.Thumb: The first digit on the radial side of the hand which in humans lies opposite the other four.Motor Cortex: Area of the FRONTAL LOBE concerned with primary motor control located in the dorsal PRECENTRAL GYRUS immediately anterior to the central sulcus. It is comprised of three areas: the primary motor cortex located on the anterior paracentral lobule on the medial surface of the brain; the premotor cortex located anterior to the primary motor cortex; and the supplementary motor area located on the midline surface of the hemisphere anterior to the primary motor cortex.Eye Movements: Voluntary or reflex-controlled movements of the eye.Photic Stimulation: Investigative technique commonly used during ELECTROENCEPHALOGRAPHY in which a series of bright light flashes or visual patterns are used to elicit brain activity.Brain Mapping: Imaging techniques used to colocalize sites of brain functions or physiological activity with brain structures.Newspapers: Publications printed and distributed daily, weekly, or at some other regular and usually short interval, containing news, articles of opinion (as editorials and letters), features, advertising, and announcements of current interest. (Webster's 3d ed)Bone Density Conservation Agents: Agents that inhibit BONE RESORPTION and/or favor BONE MINERALIZATION and BONE REGENERATION. They are used to heal BONE FRACTURES and to treat METABOLIC BONE DISEASES such as OSTEOPOROSIS.Mass Media: Instruments or technological means of communication that reach large numbers of people with a common message: press, radio, television, etc.Risk Assessment: The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)Noxae: Agents capable of exerting a harmful effect on the body.Tobacco Industry: The aggregate business enterprise of agriculture, manufacture, and distribution related to tobacco and tobacco-derived products.Ethics, Business: The moral obligations governing the conduct of commercial or industrial enterprises.Marketing: Activity involved in transfer of goods from producer to consumer or in the exchange of services.Lobbying: A process whereby representatives of a particular interest group attempt to influence governmental decision makers to accept the policy desires of the lobbying organization.Economic Competition: The effort of two or more parties to secure the business of a third party by offering, usually under fair or equitable rules of business practice, the most favorable terms.UzbekistanKidney Transplantation: The transference of a kidney from one human or animal to another.Biopsy: Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.Graft Rejection: An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient.Transplantation, Homologous: Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.Funnel Chest: A developmental anomaly in which the lower sternum is posteriorly dislocated and concavely deformed, resulting in a funnel-shaped thorax.Graft Survival: The survival of a graft in a host, the factors responsible for the survival and the changes occurring within the graft during growth in the host.Calcinosis: Pathologic deposition of calcium salts in tissues.Investigational New Drug Application: An application that must be submitted to a regulatory agency (the FDA in the United States) before a drug can be studied in humans. This application includes results of previous experiments; how, where, and by whom the new studies will be conducted; the chemical structure of the compound; how it is thought to work in the body; any toxic effects found in animal studies; and how the compound is manufactured. (From the "New Medicines in Development" Series produced by the Pharmaceutical Manufacturers Association and published irregularly.)Atovaquone: A hydroxynaphthoquinone that has antimicrobial activity and is being used in antimalarial protocols.Drugs, Investigational: Drugs which have received FDA approval for human testing but have yet to be approved for commercial marketing. This includes drugs used for treatment while they still are undergoing clinical trials (Treatment IND). The main heading includes drugs under investigation in foreign countries.Pneumonia, Pneumocystis: A pulmonary disease in humans occurring in immunodeficient or malnourished patients or infants, characterized by DYSPNEA, tachypnea, and HYPOXEMIA. Pneumocystis pneumonia is a frequently seen opportunistic infection in AIDS. It is caused by the fungus PNEUMOCYSTIS JIROVECII. The disease is also found in other MAMMALS where it is caused by related species of Pneumocystis.Pneumocystis: A genus of ascomycetous FUNGI, family Pneumocystidaceae, order Pneumocystidales. It includes various host-specific species causing PNEUMOCYSTIS PNEUMONIA in humans and other MAMMALS.United States Food and Drug Administration: An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.Pneumocystis carinii: The prototype species of PNEUMOCYSTIS infecting the laboratory rat, Rattus norvegicus (RATS). It was formerly called Pneumocystis carinii f. sp. carinii. Other species of Pneumocystis can also infect rats.

A multicomponent intervention to prevent delirium in hospitalized older patients. (1/2588)

BACKGROUND: Since in hospitalized older patients delirium is associated with poor outcomes, we evaluated the effectiveness of a multicomponent strategy for the prevention of delirium. METHODS: We studied 852 patients 70 years of age or older who had been admitted to the general-medicine service at a teaching hospital. Patients from one intervention unit and two usual-care units were enrolled by means of a prospective matching strategy. The intervention consisted of standardized protocols for the management of six risk factors for delirium: cognitive impairment, sleep deprivation, immobility, visual impairment, hearing impairment, and dehydration. Delirium, the primary outcome, was assessed daily until discharge. RESULTS: Delirium developed in 9.9 percent of the intervention group as compared with 15.0 percent of the usual-care group, (matched odds ratio, 0.60; 95 percent confidence interval, 0.39 to 0.92). The total number of days with delirium (105 vs. 161, P=0.02) and the total number of episodes (62 vs. 90, P=0.03) were significantly lower in the intervention group. However, the severity of delirium and recurrence rates were not significantly different. The overall rate of adherence to the intervention was 87 percent, and the total number of targeted risk factors per patient was significantly reduced. Intervention was associated with significant improvement in the degree of cognitive impairment among patients with cognitive impairment at admission and a reduction in the rate of use of sleep medications among all patients. Among the other risk factors per patient there were trends toward improvement in immobility, visual impairment, and hearing impairment. CONCLUSIONS: The risk-factor intervention strategy that we studied resulted in significant reductions in the number and duration of episodes of delirium in hospitalized older patients. The intervention had no significant effect on the severity of delirium or on recurrence rates; this finding suggests that primary prevention of delirium is probably the most effective treatment strategy.  (+info)

Can we cure indolent lymphomas? (2/2588)

The current consensus is that indolent lymphomas are incurable disorders. There are some indications that these malignancies are potentially curable. Indeed, not all indolent lymphomas are currently incurable. For example, patients with Ann Arbor stage I-II indolent lymphomas can experience long-term disease-free survival and probable cure. Also, from the available literature data, it seems that the achievement of a molecular complete remission is a desirable objective. Patients who achieve a persistently negative PCR state seldom relapse, whereas the opposite is true for persistently positive cases. In view of its excellent correlation with disease-free survival when examined serially in multiple blood or marrow samples, the PCR technique has the potential of providing a tumor marker that can be used as an early end point for clinical trials. By serving as an early surrogate end point, PCR could play an important role in expediting the development of new treatment strategies. Whether IFN is capable of increasing the molecular complete remission rate as measured by PCR is not known. However, it is clear that from the clinical standpoint, IFN has been able to increase 2-fold the length of remission in patients with advanced indolent lymphomas. In at least two studies, this has been associated with prolongation of survival. More intensive regimens such as alternating triple therapy, when used in combination with IFN, seem to have improved the quality of remissions as judged by the PCR assay. Finally, the site where the bcl-2 breakpoint occurs seems to have clinical significance. Those follicular lymphomas with germ-line bcl-2, in our experience, have behaved more aggressively than the others, and their failure-free survival seems different from the usual indolent lymphomas and more closely resembles the large cell lymphomas. Although the biological significance of this observation is not yet understood, this group might actually constitute a prognostically different subset with a more aggressive and perhaps more curable lymphoma. Whether the plateau observed in their failure-free survival curve will be maintained with more follow-up and whether they might be a curable subset remain to be determined.  (+info)

Low-molecular-weight heparin in outpatient treatment of DVT. (3/2588)

Patients with a diagnosis of acute deep venous thrombosis have traditionally been hospitalized and treated with unfractionated heparin followed by oral anticoagulation therapy. Several clinical trials have shown that low-molecular-weight heparin is at least as safe and effective as unfractionated heparin in the treatment of uncomplicated deep venous thrombosis. The use of low-molecular-weight heparin in an outpatient program for the management of deep venous thrombosis provides a treatment alternative to hospitalization in selected patients. Use of low-molecular-weight heparin on an outpatient basis requires coordination of care, laboratory monitoring, and patient education and participation in treatment. Overlapping the initiation of warfarin permits long-term anticoagulation. Advantages include a decreased incidence of heparin-induced thrombocytopenia and fewer episodes of bleeding complications. Future clinical trials evaluating the safety and efficacy of low-molecular-weight heparin in the treatment of complicated deep venous thrombosis will further define appropriate indications for use and strategies for outpatient management.  (+info)

Time course of respiratory decompensation in chronic obstructive pulmonary disease: a prospective, double-blind study of peak flow changes prior to emergency department visits. (4/2588)

The aim of this study was to look at changes in peak expiratory flow rates (PEFR) prior to emergency department visits for decompensated chronic obstructive pulmonary disease (COPD). It was designed as a prospective, double-blind study at the Albuquerque Veterans Affairs Medical Center. Twelve patients with an irreversible component of airflow obstruction on pulmonary function tests were assessed. At entry, all subjects were instructed in the use of a mini-Wright peak flow meter with electronic data storage. They then entered a 6-month monitoring phase in which they recorded PEFR twice daily, before and after bronchodilators. The meter displays were disabled so that the patients and their physicians were blinded to all values. Medical care was provided in the customary manner. Patients were considered to have respiratory decompensation if they required treatment for airflow obstruction in the Emergency Department (ED) and no other causes of dyspnea could be identified. Simple linear regression was used to model changes in PEFR over time. The 12 subjects had 22 episodes of respiratory decompensation during 1741 patient-days of observation. Two episodes could not be analysed because of missing values. Ten episodes in seven subjects were characterized by a significant linear decline in at least one peak flow parameter prior to presentation. The mean rates of change for the four daily parameters varied from 0.22% to 0.27% predicted per day (or 1.19 to 1.44 1 min-1 day-1). The average decrement in these parameters ranged from 30.0 to 33.8 1 min-1 (or 18.6%-25.9% of their baseline values). No temporal trends were found for the 10 episodes occurring in the other five subjects. We concluded that respiratory decompensation is characterized by a gradual decline in PEFR in about half of cases. Future studies should be done to elucidate the mechanisms of respiratory distress in the other cases.  (+info)

Enhancing the identification of excessive drinkers on medical wards: a 1-year follow-up study. (5/2588)

This paper describes a 1-year follow-up study examining whether hospital ward doctors and nurses continue to take quantitative alcohol histories and provide brief intervention to problem drinkers on general medical wards after the introduction of a simple protocol. Regular training in the use of this protocol was stipulated in the annual service contract between the Health Authority and the Hospital Trusts. Improvements in staff practice persisted at 1-year follow-up, although it fell from a peak at an earlier phase of the study. The positive role of state purchasers of health services in sustaining improvements in clinical practice is discussed.  (+info)

Agreeing criteria for audit of the management of induced abortion: an approach by national consensus survey. (6/2588)

OBJECTIVE: To obtain a national consensus view of suggested criteria for good quality care in induced abortion to serve as a basis for standards for audit to assess current clinical practice. DESIGN: Postal, questionnaire survey assessing consensus agreement with criteria identified from a literature review and refined by an invited panel of four gynaecologists and the gynaecology audit project in Scotland (GAPS) committee. SETTING: Scotland. SUBJECTS: All 132 practising consultant gynaecologists. MAIN MEASURES: Overall level of agreement with each of 20 suggested audit criteria. RESULTS: 121 completed questionnaires were received (response rate 92%), of which 119 were returned in time for analysis; 107 came from consultants who practised abortion routinely and were included in the analysis. Nineteen of 20 suggested criteria were validated by an overall balance of agreement. The most strongly supported criterion (agreement score +93) was for ascertaining rhesus status of the woman and prophylaxis after abortion, if indicated. The only criterion to elicit a negative agreement score (-27) was that dilatation and evacuation is the best method of abortion at 12-15 weeks' gestation. The ranked and prioritised criteria resulting from this exercise are being used within a national audit project. CONCLUSIONS: A postal questionnaire survey among interested clinicians resulted in a good response rate and enabled the audit criteria to be validated and ranked more objectively and among more clinicians, than would have been possible by group discussion.  (+info)

Audit of thrombolysis initiated in an accident and emergency department. (7/2588)

Early thrombolytic therapy after acute myocardial infarction is important in reducing mortality. To evaluate a system for reducing in-hospital delays to thrombolysis pain to needle and door to needle times to thrombolysis were audited in a major accident and emergency (A and E) department of a district general hospital and its coronary care unit (CCU), situated about 5 km away. Baseline performance over six months was assessed retrospectively from notes of 43 consecutive patients (group 1) transferred to the CCU before receiving thrombolysis. Subsequently, selected patients (23) were allowed to receive thrombolysis in the A and E department before transfer to the CCU. The agent was administered by medical staff in the department after receiving oral confirmation of myocardial infarction from the admitting medical officer in the CCU on receipt of fax transmission of the electrocardiogram. A second prospective audit during six months from the start of the new procedure established time intervals in 23 patients eligible to receive thrombolysis in the A and E department (group 2b) and 30 ineligible patients who received thrombolysis in the CCU (group 2a). The groups did not differ significantly in case mix, pre-hospital delay, or transfer time to the CCU. In group 2b door to needle time and pain to needle time were reduced significantly (geometric mean 38 min v 121 min (group 2a) and 128 min (group 1); 141 min v 237 min (group 2a) and 242 min (group 1) respectively, both p < 0.0001). The incidence of adverse effects was not significantly different. Nine deaths occurred (six in group 1, three in group 2b), an in-hospital mortality of 9.9%. Thrombolysis can be safely instituted in the A and E department in selected patients, significantly reducing delay to treatment.  (+info)

Improving quality through cost recovery in Niger. (8/2588)

New evidence on the quality of health care from public services in Niger is discussed in terms of the relationships between quality, costs, cost-effectiveness and financing. Although structural attributes of quality appeared to improve with the pilot project in Niger, significant gaps in the implementation of diagnostic and treatment protocols were observed, particularly in monitoring vital signs, diagnostic examination and provider-patient communications. Quality improvements required significant investments in both fixed and variable costs; however, many of these costs were basic input requirements for operation. It is likely that optimal cost-effectiveness of services was not achieved because of the noted deficiencies in quality. In the test district of Boboye, the revenues from the copayments alone covered about 34% of the costs of medicines or about 20% of costs of drugs and administration. In Say, user fees covered about 50-55% of the costs of medicines or 35-40% of the amount spent on medicines and cost-recovery administration. In Boboye, taxes plus the additional copayments covered 120-180% of the cost of medicines, or 75-105% of the cost of medicines plus administration of cost recovery. Decentralized management and legal conditions in the pilot districts appeared to provide the necessary structure to ensure that the revenues and taxes collected would be channelled to pay for quality improvements.  (+info)

0113] Although it is shown by way of example that a browser program (e.g. 1215) may be used to access a protocol builder system by users to perform functions for developing drug protocols, it should be appreciated that other program types may be used to interface a user to server process 1213 or a protocol builder system. For instance, an application program 1214 that is specially-developed to manage drug protocol development may be provided to permit a user to participate in a project, answer challenge questions, etc., according to various embodiments of the present invention. A client program may be, for example, a thin client including an interface for submitting and monitoring challenge questions, and/or drug protocol development projects. Alternatively, the client may be a scripted program, or any other type of program having the capability of transferring data. According to one embodiment, such client programs may, for example, be downloaded and installed over the network. Further, these ...
Given a potentially huge set of candidate criteria, our goal is to help users choose the most appropriate criteria from among the candidates. In this work, we assume that the candidate criteria exist in some document(s) in a given repository, either separately from different documents or together in the same document, and our technical objective is to rank these candidates according to their appropriateness to the task at hand. As mentioned previously, such task would be to put together a clinical trial protocol about some particular disease, treatment, or drug.. To provide a concrete idea of our problem, the following is a snippet of a clinical trial protocol, downloaded from the clinical trials website http://www.clinicaltrials.gov, and modified for presentation as an example. It shows the title, the objective of the clinical trial as well as the inclusion and exclusion criteria.. Title: Antioxidant Systems and Age-Related Macular Degeneration Objective:. The objective of this study is to ...
By (author): John E. Turrentine. Expanded and updated, the new edition of the bestselling Clinical Protocols in Obstetrics and Gynecology is the definitive quick-reference for use in office practice and hospital settings. With information drawn from ACOG technical bulletins, OB/GYN publications, articles, textbooks, computer sources, and the authors vast personal experience, outlines of more than 400 clinical protocols help ensure that everyone on the team is on the same page.. Flowcharts and algorithms make common problems seem simpler. Tables and decision trees make the information easy to refer to when running from room to room during a busy day in the office or hospital. This complete, up-to-date coverage makes Clinical Protocols in Obstetrics and Gynecology, Third Edition the best available study guide for board certification and a complete reference for busy obstetricians and gynecologists ...
Self-monitoring of blood glucose in patients with diabetes has traditionally been considered to be a pillar of diabetes self-care. Scientific examinations of SMBG in T2DM have provided mixed results. An early epidemiological evaluation of the issue using a retrospective, longitudinal analysis showed that nonfatal micro- and macrovascular event rates along with fatal event rates were lower in individuals performing SMBG routinely as compared to those who were not [3]. A multitude of clinical trials followed. Several showed a significant benefit from SMBG testing on improving glycemic control [4-7], while others found no evidence of benefit [16]. In fact, some studies even suggested harm from routine SMBG in patients with T2DM, specifically, higher rates of depression and increased cost without accompanying benefits [31].. Given these mixed results, a series of meta-analyses and systematic reviews were conducted to investigate the benefit or lack thereof of SMBG on glycemic lowering in patients ...
Discussion. We found that ACPAP simplified and facilitated the effective management of patients at intermediate risk of adverse cardiac events at our hospital. Two-thirds of patients assessed with ACPAP were reclassified as low risk and discharged early a mean of 14 hours after presentation, allowing early return to work and normal activities; 1% of these patients had cardiac events (all elective revascularisations) by six-month follow-up, compared with 19% of high-risk patients. We have identified no missed AMIs since adopting the protocol. However, a low rate of missed AMI depends on the willingness of emergency staff to enrol patients with both "typical" and "atypical" symptoms in the protocol, particularly the elderly and those with diabetes, whose presentations are often "atypical" or even silent.. A limitation of the study was that it was a clinical audit and not a prospective controlled trial of differing strategies in managing chest pain. However, although observational, our study had ...
When you express interest in a specific study, the information from your profile will be sent to the doctor conducting that study. If youre eligible to participate, you may be contacted by a nurse or study coordinator. If you select a health category rather than a specific study, doctors who have active studies in that area may contact you to ask if you would like to participate. In both cases, you will be contacted by the preferred method (email or phone) that you specified in your profile. ...
The WHO Regional Office for Europe is revising five clinical protocols on treatment of and care for people with HIV and AIDS, which were part of the 13 protocols set combined in one volume in 2007.. The protocols are the cornerstone of the strategic actions that WHO has taken as part of its contribution to ensure universal access to treatment and care for people living with HIV and to comprehensively address their health problems, including preventing and treating co-infections and co-morbidities - one of the six priority areas of the European Action Plan for HIV/AIDS 2012-2015.. Addressing the diverse capacity of the countries in the WHO European Region to implement recommendations, the revised protocols provide preferable, alternative and acceptable options which allow countries to choose appropriate recommendations depending on the available resources. Five revised clinical protocols are envisaged for publication this year.. ...
The condition of effectiveness is not fully fulfilled - the new unified clinical protocol was developed based on evidentiary medicine, however the focus is made on the compliance with clinical efficacy without due consideration of the economic aspect. For example, in cases when resistance profile is not known (for a term of 2 months), it is economically more advantageous to start treatment with more expensive and more effective treatment regimen, as not only the cost of medication should be accounted but the cost of a patients stay in a hospital as well (which includes not only material costs but also psychological challenge for a patient to be apart from his/her usual social environment for a long time). Another example: according with WHO recommendations, for diagnosis with molecular DNA tests, there should be developed extended criteria regarding the patients who must undergo such tests; however, such criteria in the applicable unified clinical protocol are essentially restricted (article ...
TY - CHAP. T1 - Best Practices in Evaluating Novel Biomarker Fit for Purpose and Translatability. AU - Baker, Amanda F. PY - 2016/1/1. Y1 - 2016/1/1. N2 - This chapter discusses various tactical aspects to consider when evaluating novel biomarker translatability. The evaluation procedures warrant careful attention in order to leverage the most appropriate traditional and novel biomarkers in the relevant biological matrices. Integration of biomarkers into clinical protocols requires incorporation of biomarker analysis into one of the study objectives. The chapter also describes the use of fit-for-purpose biomarkers in different phases of drug development. When translating a biomarker from preclinical to clinical studies, the species specificity of the assay should be evaluated. Evidence-based protocols for sample collection should be developed and implemented for each biomarker analyzed. When multiple biomarkers are to be analyzed, multiple types of collection containers/tubes may be necessary. ...
Dear colleagues and visitors to our site! Entered into force "Clinical Protocol for the diagnosis and treatment of tuberculosis (adult and pediatric population)", which you can find on our website in the section "Organizational and methodological work" -, "Legal acts on service". Dear colleagues and visitors to our site! Entered into force "Clinical Protocol for the diagnosis and treatment of tuberculosis (adult and pediatric population)", which you can find on our website in the section "Organizational and methodological work" -, "Legal acts on .... Readmore ...
This Website Provides Over 10000 Free Medical Books and more for all Students and Doctors This Website the best choice for medical students during and after learning medicine.
Special Note 1.2: Processing and handling of CSF for analysis - please remember endotoxin is ubiquitous and can change expression of all mediators being assayed. Endotoxin free precautions should be taken for handling of all procedures (sterile precautions and using endotoxin free solutions should suffice ...
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Analyze data Analytical skills Control data Develop clinical trial protocols Develop protocols Guide students Interact with nurses Interact with physicians Interpret data Monitor a clinical study Report data Search literature on clinical trials Write papers Write protocolsAdjust processes and methodsassess the needs of the project(s)/program(s) and make changes in process, work flow and/or assignments.Assign activitiesAssist with experimentsAssist with proceduresAttend at steering committee meetingsAttend investigator meetingAttend seminarsAttend seminars, courses and meetings within and outside the companyCalculate timelines for conducting and completing the trialClinical data collectionCoachcollaborate in research projects at universitiesCollaborate with medical teamCollaborate with principal investigatorCollaborate with project teamCollect dataCommunicate with investigatorCommunicate with sponsorConduct animal studiesConduct literature searchesConduct research at universitiesConduct ...
There are many reasons why clinical trials dont work well. A major one is not making them useful or interesting to patients. I had high hopes when I heard about the recent clinical trial protocol (plan) template from the U.S. Food & Drug Administration (FDA) and the National Institutes of Health (NIH) Joint Leadership Council (JLC). Unfortunately, it looks like they…
This study suggests that, compared with conventional management, a treatment programme for failure to thrive delivered by health visitors using strict diagnostic criteria and assessment protocols, with limited additional support, results in a weight gain of around half an intercentile space using UK charts, equivalent to about 550 g. This was despite only just over half of the intervention group receiving the full programme, because a fifth showed prior spontaneous recovery and another quarter exercised their right to decline aspects of the programme. The fairly low levels of compliance with the follow up home visit were also disappointing, but compliance rates were similar in both arms, and those interviewed were representative of the original group. It is fortunate, however, that routine follow up weights were also retrieved for a high proportion of the group, which also showed a significant treatment benefit.. The severity of failure to thrive found in this cohort was similar to previous ...
Prior to being applied to the new bisphenol A (BPA) re‐evaluation, the study appraisal methodology described in the 2017 BPA hazard assessment protocol, i.e. the so‐called 2017 methodology, was tested on a selection of studies that had been previously a .... ...
The Imaging Translational Technology Core (Imaging TTC) facilitates one-on-one consultation with imaging experts for study design, imaging protocol development and study implementation. The core facilitates integrated use of imaging resources in translational projects and clinical trials and offers research imaging management infrastructure through the Johns Hopkins Medical Image Research Archive Center for research data storage and distribution Imaging also offers CORIS, a one week observership program for anyone interested in radiology. Participants have an opportunity to shadow Katarzyna (Kasia) J. Macura, MD, PhD, FACR, Professor of Radiology, Urology and Oncology. For more information and to schedule a time, contact Atefeh Ameri at … Continue reading →. ...
It is well accepted that the clinical features of patients with HPV-driven HNSCC are distinct from those of patients with HPV-negative disease. These include distinct sites of origin of the disease (e.g., tonsil and base of tongue), younger age, and improved relapse-free survival following initial definitive treatment. Clinically, an emphasis on protocol development for patients with HPV-driven HNSCCs has consisted largely of de-escalation of standard therapy with a lower dose of radiation, more limited resection, or deintensification of chemotherapy.. Initial NGS studies of HPV-positive patients confirmed that these individuals harbor few genomic alterations in TP53 and/or CDKN2A, presumably due to the activity of the HPV E6 and E7 viral oncoproteins (11). These studies also suggested that HPV-driven HNSCCs display less genomic complexity as compared with HPV-negative disease, though TCGA and other more recent cohorts did not confirm this finding, perhaps due to tobacco use in the HPV-positive ...
Hi, Currently in middle of third year nursing essay. Anyone have any idea where to get a definition of clinical protocols and standards - really stuck! Cheers Trigger x
The instructions given here are for the original, and what I like to call, Classic Protocol 1000. If you do further research you will find that we and many other people have tried various versions of Protocol 1000 over the years. While most all of the slight variations of Protocol 1000 have been successful, according to reports we have received from around the world the success has never been as good as the original protocol of mixing the dose fresh every hour. Protocol 1000 is taking a maximum of 3 drops of activated MMS (MMS1) in 4 ounces/120 ml of water once each hour, for eight consecutive hours, every day, for three weeks or until well. Do not start out at 3 drops an hour. Try to build up to 3 drops slowly. If your body does not tolerate an increase of drops, stick with what works best for you. Your health may be recovered taking less than 3 drops in each dose. Some people have recovered their health taking 1 or 2 drops per hour, and in rare cases even less. It is best to start out slow and ...
List of Protocol pages. To create a protocol page please use the following naming convention: Kubke_Lab:Protocols/Protocol_name ...
Jul 3, 2014 ... Rather, our focus is on the ability of more exclusive approaches to ... 2 This is how the CBD defines genetic resources, Article 2, Use of .... 5 The exact temporal and functional scopes of the Nagoya Protocol are ... development and im... ...
Questions have been raised about Séralinis study protocol. But Séralini designed his study to be comparable with Monsantos - thus the design was similar.
As part of our efforts to make science more reproducible, were working with Bio-protocol to link the protocols they host with research published at eLife. To request a protocol for an eLife paper thats not yet available on Bio-protocol, simply fill in the form below and they will send a request to the author. If the author chooses to make it available, the Bio-protocol team will let you know via email and a link will be added to the eLife article. Your details will not be shared with the authors unless you opt-in to share them below. ...
As part of our efforts to make science more reproducible, were working with Bio-protocol to link the protocols they host with research published at eLife. To request a protocol for an eLife paper thats not yet available on Bio-protocol, simply fill in the form below and they will send a request to the author. If the author chooses to make it available, the Bio-protocol team will let you know via email and a link will be added to the eLife article. Your details will not be shared with the authors unless you opt-in to share them below. ...
This section of the |em>Protocols and Applications Guide|/em> covers proteins. As well as providing some general background into proteins and their biology, the guide covers commonly used protocols for expression, purification, analysis, detection and assays. 
This section of the |em|Protocols and Applications Guide|/em| covers proteins. As well as providing some general background into proteins and their biology, the guide covers commonly used protocols for expression, purification, analysis, detection and assays. 
Formal and symbolic techniques are extremely useful for modelling and analysing security protocols. They have helped to improve our understanding of such protocols, allowed us to discover flaws, and t
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Receptors, located on both the cell surface and within the cell, are the molecular targets through which drugs produce their beneficial effects in various disease states
On successful completion of this module students should be able to: Demonstrate a detailed knowledge of the epidemiological and pathophysiological evidence which underpins current guidelines for the inclusion of physical activity in the maintenance of a healthy lifestyle; Demonstrate an awareness of pre-assessment screening, risk stratification and issues related to the selection of safe and appropriate physiological assessment protocols for both healthy individuals and those suffering from chronic disease; Interpret and evaluate data from physiological assessment protocols and demonstrate an awareness of validity and reliability issues ...
Given the continued destruction, disturbance and fragmentation of tropical forests, and the associated extinction of species (Sayer & Whitmore 1991; May, Lawton & Stork 1995; Turner 1996), there is an urgent need to develop and test standardized methods for sampling biodiversity (Sutton & Collins 1991; Stork & Samways 1995). This has prompted a growing literature on the search for bioindicators, particularly for insects, because they form the bulk of species and animal biomass in terrestrial habitats and have a strong influence over many ecosystem processes. McGeoch (1998) reviewed the selection and utility of insects as indicators, and emphasized the need for explicit aims and hypothesis testing when nominating a species or group of taxa as a bioindicator. The basic purpose of bioindicators, whatever the ultimate aim, is to indicate a relationship with another biotic or abiotic variable. These relationships with other variables are, however, only as good as the sampling method employed to ...
The Integrative Cartilage Research Group at the University of Melbourne researches links between microstructure, mechanics and biological signalling networks.. Glycosaminoglycans, collagen, DNA, and mineral content are just some of the markers used to understand biological tissue quality. Reproducibly extracting and measuring these markers from small structures (e.g. mouse knees) can be challenging. In this work, we are developing robust in vivo protocols that will form the foundation for future research projects.. The ICR Group is developing, refining, and using biomedical engineering tools and concepts, to explore and understand the effects of mechanics on living musculoskeletal systems on the molecular, cellular, and organ level of organisation, while maintaining a philosophy of respect and compassion for all human and animal life.. The project involves monitoring of biosignals and biomarkers in biological constructs and in vivo animal models. The work requires a creative approach to ...
Explicate the Management Strategies and Strategic Components to Identify Structural Practices (Participants: approximately 5775 online participants).. We propose to use an iterative online engagement strategy based on the Qualtrics [40] platform to explore variation in Management Strategies and Structural Practices focused on HAI-prevention across an initial sample of hospitals. In this step, we will build a survey instrument and deploy a computer-assisted Delphi method to conduct this assessment. The Delphi method is an iterative engagement technique where knowledgeable individuals are systematically asked a series of questions in multiple rounds of queries in five process stages, Preparation, Generation, Structure, Analysis, and Summary. Throughout this process, the research team will provide summaries of results to participants as findings emerge across the different participants perspectives. The Delphi study stages are explained below.. Stage 1, Preparation will involve identification of ...
|strong|Introduction|/strong|: Zambias under-resourced public health system will not be able to deliver on its health-related Millennium Development Goals without a substantial acceleration in mortality reduction. Reducing mortality will depend not only upon increasing access to health care but also upon improving the quality of care that is delivered. Our project proposes to improve the quality of clinical care and to improve utilization of that care,through a targeted quality improvement (QI) intervention delivered at the facility and community level. |strong|Description of implementation|/strong|: The project is being carried out 42 primary health care facilities that serve a largely rural population of more than 450,000 in Zambias Lusaka Province. We have deployed six QI teams toimplement consensus clinical protocols, forms, and systems at each site. The QI teams define new clinical quality expectations and provide tools needed to deliver on those expectations. They also monitor the care that
In recent years, evidence-based protocols of bundled therapies have improved survival of severe sepsis in developed countries. In sub-Saharan Africa, simple therapies such as IV fluids and early antibiotics are frequently under-utilized. Studies of fluid interventions in the region, however, have demonstrated conflicting results. Outcomes in septic patients may be further affected by delays in the diagnosis of tuberculosis-associated severe sepsis.. The aims of this study are (1) To assess the impact on survival of a simple evidence-based protocol for severe sepsis with hypotensionor septic shock, (2) To evaluate the cost of implementation for a simplified severe sepsis protocol, (3) To develop a clinical diagnostic score for identifying tuberculosis in HIV positive patients with severe sepsis, and (4) To assess the performance of the Xpert TB/RIF rapid PCR system and urine lipoarabinomannan assay for diagnosing tuberculosis in HIV positive patients with severe sepsis. ...
In recent years, evidence-based protocols of bundled therapies have improved survival of severe sepsis in developed countries. In sub-Saharan Africa, simple therapies such as IV fluids and early antibiotics are frequently under-utilized. Studies of fluid interventions in the region, however, have demonstrated conflicting results. Outcomes in septic patients may be further affected by delays in the diagnosis of tuberculosis-associated severe sepsis.. The aims of this study are (1) To assess the impact on survival of a simple evidence-based protocol for severe sepsis with hypotensionor septic shock, (2) To evaluate the cost of implementation for a simplified severe sepsis protocol, (3) To develop a clinical diagnostic score for identifying tuberculosis in HIV positive patients with severe sepsis, and (4) To assess the performance of the Xpert TB/RIF rapid PCR system and urine lipoarabinomannan assay for diagnosing tuberculosis in HIV positive patients with severe sepsis. ...
Because the advantages of clinical trials registries are so great and because several forces now demand their creation, the challenge is to develop systems that will be accessible to a range of persons and serve a range of interrelated purposes (39). Given these broad goals, several authors have suggested the types of elements that should be included in a clinical trials registry (7, 22, 25, 27). All agree on the high-level categories of information that should be present in a full clinical trials protocol (40), although there are differences in the emphasis placed on those categories. General and administrative information includes the trial name or title, a registration number, the funding source, the site at which the trial is being conducted, the name and affiliation of the investigators, the study start and completion dates, and the recruiting status of the trial. The purpose and objectives of the trial include the disease or condition being treated or evaluated, the treatments or ...
Infertility is defined as inability of a couple to conceive naturally after one year of regular unprotected sexual intercourse. It remains a major clinical and social problem, affecting perhaps one couple in six. Evaluation usually starts after 12 months; however it may be indicated earlier. The most common causes of infertility are: male factor such as sperm abnormalities, female factor such as ovulation dysfunction and tubal pathology, combined male and female factors and unexplained infertility. The aim of this study is to provide the healthcare professionals an evidence-based management protocol for infertile couples away from medical information overload. A comprehensive review where the literature was searched for
Skaga, Erlend; Kulesskiy, Evgeny; Brynjulfsen, Marit; Sandberg, Cecilie Jonsgar; Kyttala, Aija; Langmoen, Iver Arne; Laakso, Aki; Gaal-Paavola, Em-Lia; Perola, Markus; Wennerberg, Krister; Vik-Mo, Einar ...
BACKGROUND AND AIMS: Several changes in the management protocols of anaesthesia for geriatric patients were introduced into clinical practice to improve the outcome. Very few studies have evaluated the impact of these management protocols. The aim of our study was to evaluate impact of some of the changes in the peri-operative management protocols of geriatric patients undergoing elective orthopaedic lower limb surgeries on the outcomes. METHODS: A retrospective chart review of thirty-eight surgical patients from 1999 (Group 1999) before the introduction of changes and 107 patients from 2007 (Group 2007) after establishing changes was performed and data of peri-operative variables were collected and analysed ...
Prednisone didnt make. This is why I wait at least three months. kept them satiated without feeling hungry all day.Most of them did fine on.Clinical trial protocol. Treatment repeats every 3 weeks until day 365 from the beginning of. *Patients receive oral prednisolone 3 times daily on.. prednisone 20 mg tablets for dogs, prednisone 10 mg package insert, prednisone 20 mg 3 times daily, buy prednisone dose pack, prednisone 20 mg dosing.area 2-3 times a day. eur-lex.europa.eu. ES A method for preparing a transdermal absorptive drug formulation containing 3-isobutyryl-2-isopropylpyrazolo.. Avoid contact with people friday glucocorticoid effects of prednisone 3 minutes for. not potentiate the beta times times the anti. teens consume each day.3) Accords barrés (avancé) 4) Les power chords; Accords à 4 sons. 1) Les accords 7ème de dominante; 2) Les accords Majeurs 7 ouverts; 3) Transposition des accords.To help acne how to take 10mg 6 5 4 3 2 1 50lb dog 50mg prednisone thrombocytopenia heart ...
Nivestim 12 MU/ 0.2 ml solution for injection/infusion, Nivestim 30 MU/ 0.5 ml solution for injection/infusion, Nivestim 48MU/ 0.5 ml solution for injection/infusion - Summary of Product Characteristics (SmPC) by Hospira UK Ltd
Assessment should begin with a review of the institutions mission statement and overall goals. What are the institutions priorities, and what evidence can demonstrate their achievement? How can the institution best combine summative assessment (which focuses on learners development at a particular time) and formative assessment (a more holistic approach that uses multiple points of measurement to provide continuous feedback and improve educational opportunities) to meet its goals? By answering these and related questions, administrators can determine which assessment methods and tools to use.. The next step in developing an assessment protocol is to explore the institutional context and available resources, including others who are already engaged in assessment. This process should lead to the creation of a multiunit assessment team, as the undertaking is too complex for any one office to implement. The team should develop an assessment plan and review it regularly for refinement. Table 1 ...
Subarachnoid hemorrhage, traumatic brain injury and cardiogenic shock are diseases that can be life-threatening and might require weeks of intensive medical care. Administration of medication is an essential part of the treatment. According to current practice, the route of drug administration in critically ill patients can be enteral or parenteral depending on the available drug format and vigilance of patients. However, there are many studies in the literature that report a disturbance of gastrointestinal function in critically ill patients. Therefore, the question of whether the enteral route of drug administration in critically ill patients is pharmacokinetically meaningful should be investigated in this study ...
The aim of this study was to compare the long term clinical outcome of patients with syndesmosis ruptures, who were treated with static screw fixation or dynamic TightRope fixation.. ...
This summary abstract describes the methodology used to evaluate the effect of pellet pellet and pellet clad interactions with consideration of the interfacial bonding efficiency on UNF vibration integrity. This methodology provides a solid roadmap for further protocol development with respect to effective lifetime prediction of a UNF system under normal transportation vibration. The proposed methodology that couples FEA simulations and experimental exploration efforts is also under development. The current methodology is focused on assessing the influence of interfacial bonding at the pellet pellet and the pellet clad interfaces on UNF vibration integrity. The FEA simulation results were also calibrated and benchmarked with the fatigue aging data obtained from reversible bending fatigue testing. ...
The intent of these learning modules is to provide consistent and concise information to all providers. The content of the Module has been reviewed by the Protocol Development and Review Sub-Committee, and, where applicable, includes the specific standing order, resource and reference material, and instructions for completing the Self-Learning Module to obtain continuing education credit. One hour of SAEMS continuing education credit may be issued following successful completion of the module.. EMS Self-Learning Modules. ...
Clinical Research, Clinical Study, Clinical Trial, and Clinical Protocol all concern the same topic. These terms are often used interchangeably to talk about scientific studies that use people to understand if new drugs, treatments and devices are safe and effective. Clinical studies cannot happen until basic research in a laboratory determines the new treatment, drug or device is successful and safe. Once basic research indicates scientific promise, the FDA must approve continuing the research and beginning to test in people. Carefully controlled and well-designed clinical trials are performed by highly trained medical professionals to understand how this new treatment will work in people. The clinical trial is trying to duplicate the promising lab results in people.. Clinical Trials are conducted in four phases that occur in sequential order. Each phase tends to have a different purpose and helps answer different questions. Each phase is considered a separate trial. After completion of each ...
As a resident computer scientist at NINDS Translational Neuroradiology Section (TNS) lab, Moayeri developed code that helped accelerate data-processing steps in experiments tied to spinal cord research and worked side by side with leading scientists conducting basic and clinical biomedical research. He also worked in the clinical center, which left him with a strong sense of validation that his contributions could make a difference.. "Often, patients who come to the NIH come out of necessity, as the already established clinical protocols are not sufficient to help these patients," says Moayeri. "Seeing how many people would come from all over the country to the NIH really led me to believe in what I was working on and gave me a new sense of purpose.". Moayeris work in the TNS lab focused on measuring and capturing data of MS disease evolution taken from magnetic resonance imaging (MRI). Examining MRI scans of spinal cord lesions, Moayeri isolated quantitative data. Typically, this ...
Enhanced recovery after surgery (ERAS) is a multidimensional approach to improving the care of surgical patients using subspecialty- and procedure-specific evidence-based protocols. The literature provides evidence of the benefits of ERAS implementat
Founded in 1994, Theralase Technologies Inc. designs, develops and manufactures super-pulsed, cool laser technology for a wide range of human, companion animal and equine applications. Theralase is committed to provide cutting-edge pre-clinical and clinical research to remain the most clinically and scientifically supported therapeutic medical laser on the market. The highly trained scientific, clinical and engineering Theralase team continuously brings our valued customers the most advanced technology on the market, while our sales, marketing, clinical training, customer service and finance teams bring superior customer service, the latest interactive training, the most up to date clinical protocols and the best financing options to accelerate the financial and clinical success of your practice. READ MORE ...
One can reduce the complexity of making a diagnosis of SLE by using conceptual models. There are two such models, one separate illnesses, the other linear illness; both cluster SLEs disparate elements. The separate illnesses model posits that typical, overlap, UAS and antibody-only SLE are separate but related illnesses. A strength of this model is that it assigns different, targetable biological mechanisms to each diagnosis. Another strength is that a diagnosis, once made, does not change.37-40 Weaknesses of this model are that, in clinical practice, ambiguous diagnoses occur often, blurring the separating lines, and that diagnoses do sometimes change. Clinical protocols that rigidly adhere to sharp distinctions among diagnoses may remove options available to the treating physician. Another weakness is that insights suggested by evolving phenotypes may be unseen if an investigator believes that change of diagnosis cannot occur.30 The linear illness model posits that UAS, overlap, antibody-only ...
Cabernet works closely with clients to understand their needs and goals and then deliver timely, executable clinical protocols that provide actionable answers for the key scientific, regulatory, and payer questions in all phases of drug development. We also develop study documentation, such as study-procedure manuals, informed consents, and clinicaltrials.gov summaries. We can create and manage external clinical-study committees including advisory, adjudication, and drug-safety monitoring boards.. ...
Testing of methylation goes beyond MTHFR.. Learn about the methylation process, genetic testing for potential defects and clinical protocols for testing the methylation function and effective treatment options which include dietary changes and the proper supplementation.. This webinar will give you clinical and practical guidance in:. ...
Use IQ Scripts to gain control over your clinical processes. IQ Scripts define patient pathways and clinical protocols, and how MOSAIQ collects data.
Internet-Draft Routing Information Base Info Model October 2015 protocol-based RIB population suffices for most use cases where distributed network control is used. However there are use cases which the network operators currently address by configuring static routes, policies and RIB import/export rules on the routers. There is also a growing list of use cases [I-D.white-i2rs-use-case], [I-D.hares-i2rs-use-case-vn-vc] in which a network operator might want to program the RIB based on data unrelated to just routing (within that networks domain). Programming the RIB could be based on other information such as routing data in the adjacent domain or the load on storage and compute in the given domain. Or it could simply be a programmatic way of creating on-demand dynamic overlays (e.g. GRE tunnels) between compute hosts (without requiring the hosts to run traditional routing protocols). If there was a standardized publicly documented programmatic interface to a RIB, it would enable further ...
TY - CHAP. T1 - Nuclear oncology 2. T2 - Scintigrahic imaging. AU - Muzaffar, Razi. AU - Raslan, Osama. AU - Osman, Medhat M.. PY - 2015/1/1. Y1 - 2015/1/1. N2 - Nuclear medicine has a major role in the management of malignant tumors. With the developments towards molecular imaging and the technological advancement of scanners providing a fusion of both physiologic and anatomic imaging, it has even become a more integral part of management protocols. This role includes detection of malignant tumors, staging and restaging of the disease, early detection of recurrence, evaluation of the response to therapy, and prediction of the prognosis. Radionuclide diagnosis and therapy for tumors depend on the characteristics of tumors including increased vascularization, increased blood fl ow, newly proliferated capillaries with more permeable walls, increased metabolic activity of cells, increased energy demand, high density of some common antigens or several specifi c antigens, and several specifi c ...
Search protocols are saved workflow parameter sets. You can save a new protocol by filling out this form, and then selecting "Save as Protocol" below, which will record the contents of the form and save it to your list of protocols. Then, selecting a saved protocol from the list to the right will automatically populate this form with all of the values stored in that protocol. All parameters except input files and task description are included when a protocol is saved ...
Search protocols are saved workflow parameter sets. You can save a new protocol by filling out this form, and then selecting "Save as Protocol" below, which will record the contents of the form and save it to your list of protocols. Then, selecting a saved protocol from the list to the right will automatically populate this form with all of the values stored in that protocol. All parameters except input files and task description are included when a protocol is saved ...
Search protocols are saved workflow parameter sets. You can save a new protocol by filling out this form, and then selecting "Save as Protocol" below, which will record the contents of the form and save it to your list of protocols. Then, selecting a saved protocol from the list to the right will automatically populate this form with all of the values stored in that protocol. All parameters except input files and task description are included when a protocol is saved ...
Background: Using the popular program AutoDock, computer-aided docking of small ligands with 6 or fewer rotatable bonds, is reasonably fast and accurate. However, docking large ligands using AutoDocks recommended standard docking protocol is less accurate and computationally slow. Results: In our earlier work, we presented a novel AutoDock-based incremental protocol (DINC) that addresses the limitations of AutoDocks standard protocol by enabling improved docking of large ligands. Instead of docking a large ligand to a target protein in one single step as done in the standard protocol, our protocol docks the large ligand in increments. In this paper, we present three detailed examples of docking using DINC and compare the docking results with those obtained using AutoDocks standard protocol. We summarize the docking results from an extended docking study that was done on 73 protein-ligand complexes comprised of large ligands. We demonstrate not only that DINC is up to 2 orders of magnitude ...
Patients may be eligible to receive active MLN0002 treatment by enrolling in Study C13008 (Long-term Safety). Patients who do not enroll in Study C13008 will be followed with a safety telephone call occurring 12 weeks after receiving their last dose of study drug for a maximum time on-study of 62 weeks. In addition, after the end of the study, patients who do not enroll in Study C13008 will participate in the 2-year follow-up ...
Bij eerdere behandeling met capecitabine geen gr 3 toxiciteit zijn opgetreden, geen bekend verminderd absorptie vermogen van de maag, bekende ernstige aandoeningen medisch instabiele conditie, complete deficiëntie van DPD, afhankelijkheid van maagzuurremmers, gebruik van inducers/remmers van P450 2C19/3A4, gebruik van medicatie die een interactie geeft met capecitabine en of esomeprazol ...
Compliance Offset Program, offset protocols, GHG protocols, offset credits, U.S. Forest Protocol, ODS protocol, urban forestry protocol, livestock protocol, new protocols, GHG accounting
Clinical charts and treatment protocols for numerous therapeutic diseases and disorders such as cardiovascular, oncology, neurological and many more. Download our FREE app now.
The DIGAMI Trial is reviewed and summarized including methods, results and conclusions. The primary and secondary endpoints are included as well as inclusion and exclusion criteria.
Abcam provides specific protocols for Anti-TFEB antibody - ChIP Grade (ab2636) : ChIP protocols, Western blot protocols, Immunohistochemistry protocols
Abcam provides specific protocols for Anti-Oct-2 antibody (ab32156) : Flow cytometry protocols, Immunohistochemistry protocols, Western blot protocols
Jacqueline Koeze is the author of this article in the Journal of Visualized Experiments: Observational Study Protocol for Repeated Clinical Examination and Critical Care Ultrasonography Within the Simple Intensive Care Studies
IVF Protocol Definition - An IVF protocol is a treatment plan that includes the course of medications administered to a woman leading up to a cycle of...
These videos are from patients like you. They are not made by doctors or nurses. Protocols are also very individual and whats shown here may not apply to you. You must verify all advice, instructions and dosages with your clinic before going ahead with your medication ...
The Tamarin prover is a state-of-the-art protocol verification tool. It supports verification of both trace and equivalence properties, a rich protocol specification language that includes support for
|p|Dr. Bob Beck developed a procedure for obtaining good health that involved four distinct treatments. These are widely referred to as the Beck Protocols. These are the four steps that he put together that allow anyone to follow the path to a healthy lif
Purchase your own copy of the Cellect-Budwig Protocol, either in online/digital form, or with traditional DVDs in a 4-disk set. Both options can also be bundled together with an additional online copy for a friend. All format versions contain 25 chapters totaling over 14 hours of video discussion.
Our Corporate Medical Protocols provide a concise overview of the criteria used for clinical determinations for a members coverage ...
Our Corporate Medical Protocols provide a concise overview of the criteria used for clinical determinations for a members coverage ...
Introduction Starting Material: 1–5 μg of DNA fragmented to 200 bp. End Repair and dA-Tailing Steps Perform end repair and dA-Tailing according to the appropriate protocol
... FOR HYPEROIL®USE Applying Hyperoil® always involves three simple steps: CLEANSE (clean the wound) APPLY COVER with a protective or abso...
... FOR HYPEROIL®USE Applying Hyperoil® always involves three simple steps: CLEANSE (clean the wound) APPLY COVER with a protective or abso...
... How do you decide whether to draw labs for renal insufficiency? Who receives contrast, what kind, and in what dose? &nb...
Advertised routes are associated with a particular tag in a routing database in a second router. A first router subsequently sends one or more messages associated with a route withdraw operation that
Page 1 of 2 - Still infected - posted in Virus, Spyware, Malware Removal: After following the Start Here protocol for malware, I am still infected. I dont know where to start next after running through the protocol three times, restatrts and all. Is there something more I can do?
OBJECTIVES: (1) To compare the effectiveness of two clinical protocols for the management of vaginal discharge in the situations where no laboratory facilities are available but speculum examination is possible and where basic laboratory facilities are available. (2) To determine clinical and simple laboratory indicators for diagnosis of patients with vaginal discharge in the local setting. DESIGN: Alternate allocation of subjects to one of two management protocols. SUBJECTS: Women presenting to university gynaecology outpatients department with a complaint of vaginal discharge. METHODS: Subjects were alternately allocated management according to one of two protocols: one without (group A) and one with (group B) immediate access to results of basic laboratory tests. Full clinical assessment including speculum examination and microbiological assessment for infection with gonorrhoea, chlamydia, candida, trichomonas, and bacterial vaginosis was performed on all women. Follow up assessment of ...
This is an uncurated book entry from our extended bookshelves, readable online now but without a stable link here. You should not bookmark this page, but you can request that we add this book to our curated collection, which has stable links ...
The BCRC provides data management, coordination and analysis for all aspects of single and multi-center clinical trials and outcomes research. We also offer full-service statistical consulting that ranges from protocol development to final analysis and report writing. The BCRC assists with study design/protocol development, central registration and randomization, data management, web-based database system development, data analysis for medical, health, and biological research projects, reporting and publications. For Public Health Students: Help with Dissertation or Thesis ...
The severity and speed of develop-ment of the exudative form, along with the efficacy and cost of the treat-ments developed to date, make it a real public health concern and a diag-nostic and therapeutic emergency.. Ophthalmologists/retinologists who treat AMD patients must be able to see them on very short notice (within a week at the most) if they present with scotoma (dark spots in their cen-tral vision) or macular syndrome: a decrease in visual acuity or difficulty reading; metamorphopsia (distorted perception of images and straight lines). In the presence of these symp-toms, eye exams must be conducted promptly, including visual acuity as-sessment via an EDTRS chart, a fundus examination via a binocular slit lamp, fluorescein and/or indocya-nine green (ICG) retinal angiography and optical coherence tomography (OCT).. If the diagnosis of subfoveal exuda-tive AMD is confirmed by these examinations, it is recommended that anti-VEFG treatment be initiated as early as possible, irrespective of ...
We have an exciting opportunity for a Portfolio Lead to join the Oncology Clinical Trials Office (OCTO), working in a team of trial management professionals running a varied portfolio of clinical trials and related sub-studies.You will be responsible for working with Chief Investigators and statisticians to develop new research proposals for funding applications, developing new clinical trial protocols, coordinating application submissions and ensuring that all appropriate documentation, reviews and approvals are in place.You will be responsible for the line management and oversight of proj ...
Purpose : Traditional visual function endpoints used to evaluate retinal disease often are not sensitive to detect clinically meaningful changes in visual function in patients with vision loss from an inherited retinal disease. The goal of this study was to create a metric which can provide a reproducible measure of functional vision in a setting that can be applied to multi-center clinical trial protocol. Methods : The visual navigation challenge (VNC) employs a homogeneous, modifiable lighting environment to an area featuring marked paths and a series of physical obstacles. Subjects were asked to navigate courses under a range of light levels. Validation included testing of normal subjects and subjects with goggle-simulated visual impairment for modeling of mild or severe retinitis pigmenta (RP). Results : Light levels were measured over the entire VNC course at intensity settings from 1-400 lux; deviations in lux values were 2.3-7.5% over the entire area. Navigation times for normal, mild RP ...
So, hoodat? Limited clues, I suppose - but the mighty, mighty Thinkolator is (you guessed it) mighty indeed … so thats enough for us to tell you that this is very likely …. Pro-Pharmaceuticals (PRWP, trades over the counter). PRWP has been over a buck for most of the year, after getting "positive feedback" on their phase III trial design from the FDA back on January 10. That drug is called Davanat, and thats all I know about it other than the tidbit from the press release, which is that this is based on their platform of "Galectin targeting therapeutic compounds" (their liver cancer idea is also based on this, apparently, and thats the one on which theyre collaborating with Mt. Sinai - preclinical, which means no human tests yet and many years from a potential product). Yeah, I dont know what Galectins are, either.. So they have a go-ahead from the FDA, sort of - the way I read it, they basically got preapproval for their submission of the clinical trial protocol and folks seem to think ...
. Picture credit....Bethany Halford PF 06650808 Phase 1 $PFE compound inspired by auristatins https://clinicaltrials.gov/ct2/show/NCT02129205 http://www.pfizer.com/sites/default/files/product-pipeline/8_7_2014_Pipeline_Update.pdf ALL DATA COMING......... Notch-3 receptor antagonists Neoplasms Breast Pfizer Cancer PF-06650808, is currently being examined in a Ph1 clinical trial (Protocol B7501001). Notch3 Researchers are also exploring the use of Notch3 targeting.
Study objective : To describe the development, design, and validation of an emergency department protocol for the identification, documentation, and referral of victims of domestic violence. Methods : We based protocol development and design on a departmental needs assessment. The validation component involved the screening of women 16 years...
For people with disability who also experience mental health issues, there can be many barriers to the accurate identification and treatment of those issues. The implication is that mental health problems go undiagnosed or are misinterpreted as a manifestation of the persons disability or are labelled as challenging behaviour. Over some years, at Scope, we have attempted to better understand mental health issues in relation to people with disability, their diagnosis and treatment. In this presentation, we aim to raise awareness of these issues and present practical ways to more accurately and effectively support people with disability and concurrent mental health needs. We present ideas from our work, and that of others, including adapted assessment protocols, modified focussed psychological treatment approaches, and ideas for working with mainstream health services.. ...
We evaluated a simple, weight-based, extended-interval dosing (EID) gentamicin protocol specifically in neonates with gestational age ≤ 33 weeks, and its impact on sub-therapeutic peaks, elevated troughs, and simplification of dosing and monitoring as compared to a weight-based, multiple daily dose (MDD) protocol. Methodology. This study evaluated all infants with GA ≤ 33 weeks receiving gentamicin 1-year before EID protocol implementation in Jan 2002, and 1-year after. The MDD protocol used 2.5mg/kg every 8, 12, 18, or 24 hrs based on weight and age groupings. The EID protocol uses 3mg/kg q24 hours if weight , 1500gm and 4mg/kg if weight ≤ 1500gm. Desired trough was ≤ 2.0 mcg/ml and peak was 5 - 12 mcg/ml. Results. Characteristics were similar for the 123 MDD and 98 EID patients reviewed. The percentage of patients with at least 1 sub-therapeutic peak was lower with EID (7% vs. 20%, p,0.001); however the percentage with at least 1 elevated trough was similar (15% vs. 19%, p=0.219). ...
WG patients were significantly warmer on arrival to the operating room (OR) and were 60% less likely to develop PH (p , 0.001). Preoperative forced air warmer use both reduced the risk of PH at time 0 intraoperatively and significantly reduced the risk of any PH intraoperatively (p , 0.001). All patients, regardless of group, experienced a drop in core temperature until a nadir occurred at 30 minutes intraoperatively for the WG and 45 minutes for the CG. At every time interval, from preoperatively to 120 minutes intraoperatively, CG patients were between 2 and 3 times more likely to experience PH (p , 0.001). All patients were warm on arrival to the postanesthesia care unit regardless of patient group. ...
Margaret Borok, MD, FRCP is a Professor of Internal Medicine at the UZCHS, with 20 years experience in clinical research and research management and manages the only referral clinic for patients with AIDS and Kaposi Sarcoma (KS). She is a committee member of the Strategies to Improve Kaposi Sarcoma (KS) Outcomes in Zimbabwe (SIKO) initiative. She sits on the international committee and KS working group of the AIDS Malignancy Consortium (AMC) under the NCI (National Cancer Institute) of the NIH. She has 27 publications that include peer-reviewed articles.. Mutsawashe Bwakura-Dangarembizi, MBChB, MMed, MSc, is a pediatrician at UZCHS, with 10 years of experience in pediatric HIV clinical trials and was instrumental in the establishment of a childrens HIV clinic at the Family Care Centre at Parirenyatwa Hospital. She is member of the IMPAACT Network Executive Committee (NEC).. Tsitsi Magure, MBChB, MMed, is a lecturer at UZCHS, with over eight years of experience in protocol development and ...
1. Dose Administration Aid (DAA) arrangements -aims to reduce the financial barriers to accessing comprehensive DAA services provided by community pharmacies to improve medication adherence and management for ACCHO clients.. 2. QUM Pharmacy Support- aims to provide additional capacity for community pharmacy involvement and support in areas including Quality Use of Medicines (QUM) planning, policy and protocol development and QUMAX Work Plan development.. 3. Home Medicine Review (HMR) Models of Support- Aims to reduce the cultural and logistical barriers and access to HMR services by ACCHO clients.. 4. QUM Devices-aims to reduce the financial barriers to access to QUM devices to improve overall delivery of medicines and management of chronic disease by ACCHO clients.. 5. QUM Education- aims to reduce financial barriers associated with access to QUM educations and health promotion for ACCHO employees and their clients. This category may also help ACCHOs access current medicine resources, promoting ...
Managing patients with conjunctivitis is difficult because of overlapping signs and symptoms between viral, bacterial, and allergic conjunctivitis that are often indistinguishable. Clinical protocols, in general, reduce the level of stress for... Full Story →. ...
Health, ...St. Jude Childrens Research Hospital and the University of Florida Pr...Under the clinical protocol St. Jude will refer patients to receive p...Proton therapy is being studied as a way to reduce potential damage to...St. Jude has the worlds largest protocol-based pediatric brain tumor...,St.,Jude,and,UF,Proton,Therapy,Institute,to,begin,proton,therapy,clinical,trial,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
Material developed to support many aspects of concussion education and protocol development is available on or through links from the CCC webpage.3 This webpage contains links to the websites of organisations that have contributed to the body of knowledge about concussion prevention and management in Canada and elsewhere. Collectively, these websites have concussion-specific resources for players, parents, coaches, teachers, organisations and others. Questions regarding protocol development can be addressed to the CCC through the Canadian Academy of Sport and Exercise Medicine.3. Recommendation 2: In situations where timely and sufficient availability of medical resources qualified for concussion management is not available, multidisciplinary collaborative approaches should be used to improve concussion management outcomes while facilitating access to medical resources where appropriate.. Current recommendations related to gradual RTP following a concussion state that medical clearance must be ...
Background Intraperitoneal chemotherapy has an established role in the treatment of selected patients with colorectal peritoneal metastases. Oxaliplatin is highly suitable as a chemotherapeutic agent...
Dharmvir S. Jaswal, Peter Q. Eichacker. In early septic shock, early goal-directed therapy did not reduce 90-day mortality. Ann Intern Med. 2015;163:JC10. doi: 10.7326/ACPJC-2015-163-4-010. Download citation file:. ...
Current sepsis therapies are largely supportive and limited to a few clinical interventions, including antibiotics, steroidal anti-inflammatory drugs (e.g., hydrocortisone) and early goal-directed therapies (EGDT). For instance, appropriate broad-spectrum antibiotics are often administered to patients to facilitate the elimination of bacterial pathogens [2]; however, the release of bacterial products (e.g., endotoxin or CpG-DNA) may adversely amplify inflammatory responses. Accordingly, anti-inflammatory steroids (e.g., hydrocortisone, methylprednisolone, dexamethasone, and fludrocortisone) are frequently used to modulate the excessive inflammatory response, despite the lack of reproducible efficacy in clinical sepsis trials [117-119]. As a supportive intervention, EGDT employs extremely tight control of numerous physiological parameters (such as central venous pressure, mean arterial blood pressure, central venous oxygen saturation, and hematocrit) with discrete, protocol-driven interventions ...
Dietary Reference Values (DRVs) for vitamin D have a key role in the prevention of vitamin D deficiency. However, despite adopting similar risk assessment protocols, estimates from authoritative agencies over the last 6 years have been diverse. This may have arisen from diverse approaches to data analysis. Modelling strategies for pooling of individual subject data from cognate vitamin D randomized controlled trials (RCTs) are likely to provide the most appropriate DRV estimates. Thus, the objective of the present work was to undertake the first-ever individual participant data (IPD)-level meta-regression, which is increasingly recognized as best practice, from seven winter-based RCTs (with 882 participants ranging in age from 4 to 90 years) of the vitamin D intake-serum 25-hydroxyvitamin D (25(OH)D) dose-response. Our IPD-derived estimates of vitamin D intakes required to maintain 97.5% of 25(OH)D concentrations >25, 30, and 50 nmol/L across the population are 10, 13, and 26 µg/day, respectively.
"ABM Clinical Protocol #11. 1 (1): 3. doi:10.1186/1746-4358-1-3. PMC 1464379. PMID 16722609.. ... Hanson LA, Söderström T (1981). "Human milk: Defense against infection". Progress in Clinical and Biological Research. 61: 147- ... Hendrickson RG, McKeown NJ (January 2012). "Is maternal opioid use hazardous to breast-fed infants?". Clinical Toxicology. 50 ( ... Haastrup MB, Pottegård A, Damkier P (February 2014). "Alcohol and breastfeeding". Basic & Clinical Pharmacology & Toxicology. ...
Weidmann, M.; Mühlberger, E.; Hufert, F. T. (2004). "Rapid detection protocol for filoviruses". Journal of Clinical Virology. ... "Journal of Clinical Microbiology. 40 (7): 2323-2330. doi:10.1128/jcm.40.7.2323-2330.2002. PMC 120575 . PMID 12089242.. ... "Clinical and Vaccine Immunology. 13 (4): 444-451. doi:10.1128/CVI.13.4.444-451.2006. PMC 1459631 . PMID 16603611.. ... "Journal of Clinical Microbiology. 45 (1): 224-226. doi:10.1128/JCM.01893-06. PMC 1828965 . PMID 17079496.. ...
In 2006, an invited group of clinicians met in Chicago and reviewed clinical evidence and protocols, and adopted a new term for ... Alice Dreger, a US professor of Clinical Medical Humanities and Bioethics, argues that little has changed in actual clinical ... Large majorities of respondents opposed standard clinical protocols.[71] 2016 Global DSD Update[edit]. A 2016 follow-up to the ... The committee stated: "clinical intervention pathways stated to be based on probabilities of cancer risk may be encapsulating ...
Clinical Toxinology Resources. Snakebite Protocols - Oxyuranus microlepidotus. "Signs and Symptoms of Envenomation: E. Fang ... Clinical Toxinology Resources. Snakebite Protocols - Oxyuranus microlepidotus. "Signs and Symptoms of Envenomation: E. Fang ... Clinical Toxinology Resources. "Oxyuranus microlepidotus -General Details, Taxonomy and Biology, Venom, Clinical Effects, ...
ABM Clinical Protocol #11. (原始内容存档于2006-08-11).. ... Is maternal opioid use hazardous to breast-fed infants?. Clinical toxicology (Philadelphia, PA). 2012-01, 50 (1): 1-14. PMID ...
Pre-clinical protocols; Clinical trials; and Infrastructure - regulatory, health economics, ethics. The mission of TERMIS is ...
The official protocol of the clinical trial of the "reversal" regimen is here: https://clinicaltrials.gov/ct2/show/NCT03774745 ... Evidence-based clinical guideline number 7 (PDF) (3rd rev. ed.). London: RCOG Press. Archived from the original (PDF) on May 29 ... "As controversial 'abortion reversal' laws increase, researcher says new data shows protocol can work". Retrieved April 23, 2018 ... Borgatta, L; Kapp, N (2011). "Clinical Guidelines. Labor induction abortion in the second trimester". Contraception. 84(1): 4- ...
"Myalgic encephalomyalitis/chronic fatigue syndrome: Clinical working definition, diagnostic and treatment protocols" (PDF) ... "Expert Review of Clinical Pharmacology. 9 (6): 755-770. doi:10.1586/17512433.2016.1172960. PMC 4917909 . PMID 27045557.. ... "Prim Care Companion Journal of Clinical Psychiatry. 10 (2): 120-128. doi:10.4088/pcc.v10n0206. PMC 2292451 . PMID 18458765.. ... London: National Institute for Health and Clinical Excellence. 2017.. *^ "ME/CFS, Myalgic Encephalomyelitis/Chronic Fatigue ...
Clinicians were then able to apply protocols for prevention based upon best clinical practices. Immobility is a significant ... Kafeza, M.; Shalhoub, J.; Salooja, N.; Bingham, L.; Spagou, K.; Davies, A. H. (2016). "A systematic review of clinical ... Kakkar VV, Cohen AT, Mohamed MS (1996). "Patients at risk of venous thromboembolism--clinical results with reviparin". Thromb. ... "Wells criteria for DVT is a reliable clinical tool to assess the risk of deep venous thrombosis in trauma patients". World ...
"Clinical protocol. Gene Therapy of Canavan Disease: AAV-2 Vector for Neurosurgical Delivery of Aspartoacylase Gene ( ) to the ...
Medical Aesthetics Clinical Skin Protocols 2014. ...
Limited clinical protocols for patient management. Limited technical operational manuals for program implementation. Health ...
... clinical study protocols are difficult to standardize if engraftment rates vary.[11] It is also expensive to house mice, ... Morton CL, Houghton PJ (2007). "Establishment of human tumor xenografts in immunodeficient mice". Nature Protocols (Protocol). ... Clinical Oncology (Review). 9 (6): 338-50. doi:10.1038/nrclinonc.2012.61. PMC 3928688. PMID 22508028.. Note: open access via ... Clinical relevance[edit]. Breast cancer[edit]. The classification of genetic breast cancer subtypes, including triple-negative ...
Perlman, Sally E.; Nakajyma, Steven T.; Hertweck, S. Paige (2004). Clinical protocols in pediatric and adolescent gynecology. ... Perlman, Sally E.; Nakajyma, Steven T.; Hertweck, S. Paige (2004). Clinical protocols in pediatric and adolescent gynecology. ... Clinical and Pathological Aspects, Greenwich Medical Media: London, a)p.453, b)p.455 c)p.460. "Muslim women in France regain ...
61-65 Perlman, Sally E.; Nakajyma, Steven T.; Hertweck, S. Paige (2004). Clinical protocols in pediatric and adolescent ... Clinical and Pathological Aspects, Greenwich Medical Media: London, a)p.453, b)p.455 c)p.460. Heger, Astrid; Emans, S. Jean; ...
Clinical working definition, diagnostic and treatment protocols» (PDF). Journal of Chronic Fatigue Syndrome. 11 (1): 7-97. doi: ... London: = National Institute for Health and Clinical Excellence. 2007. ISBN 1846294533.. *^ Sharpe M, Archard L, Banatvala J, ... Chronic Fatigue Syndrome: Clinical Course». Centers for Disease Control and Prevention. 9. mai 2006. Besøkt 15. januar 2009.. ... White PD, Sharpe MC, Chalder T, DeCesare JC, Walwyn R (2007). «Protocol for the PACE trial: a randomised controlled trial of ...
ABM Clinical Protocol #11. Archived from the original on 11 August 2006. Retrieved 13 April 2017. "Breast Surgery Likely to ... Marchesi C, Ossola P, Amerio A, Daniel BD, Tonna M, De Panfilis C (January 2016). "Clinical management of perinatal anxiety ... Hendrickson RG, McKeown NJ (January 2012). "Is maternal opioid use hazardous to breast-fed infants?". Clinical Toxicology. 50 ( ... Hanson LA, Söderström T (1981). "Human milk: Defense against infection". Progress in Clinical and Biological Research. 61: 147- ...
... an invited group of clinicians met in Chicago and reviewed clinical evidence and protocols, argued that and adopted a new term ... Large majorities of respondents opposed standard clinical protocols. A 2016 follow-up to the 2006 Consensus Statement, termed a ... There are no controlled clinical trials of the efficacy of early (less than 12 months of age) versus late surgery (in ... Clinical Pediatric and Adolescent Endocrinology.. Philadelphia: Saunders. An example of a now-obsolete recommendation to ...
... develops clinical protocols for several novel drugs. It conducts studies like assessment of novel biomarkers to ... in pre-clinical), and insulin lispro (another short-acting analogue, in pre-clinical)-covering the analog space. Novel ... to non-clinical and clinical research. Biocon has developed processes for multiple products, including Insulin, Streptokinase, ... Two Phase II clinical trials have been started one in RA and one in psoriasis, and are expected to be completed this year. ...
"What stops hospital clinical staff from following protocols? An analysis of the incidence and factors behind the failure of ... These tools can predict clinical deterioration based upon the patient's trait (e.g. has epilepsy) and detect deterioration ... UK National Institute for Health and Clinical Excellence (NICE) (July 2007). "Acutely ill patients in hospital: recognition of ... A RRS consists of two clinical components (afferent and efferent) and two organizational components (process improvement and ...
ISBN 978-94-009-8195-9. Lt Col Pankaj Talwar; Surveen Ghumann Sindhu (18 May 2012). Step by Step: Protocols in Clinical ...
This experience includes clinical assessment, diagnosis, treatment, and referral protocols. The faculty at both CMCC and UQTR ... Candidates must successfully pass Components A and B (Written Cognitive Skills Examination) to be eligible for the Clinical ... Radiology training consists of more than 360 contact hours followed by application during clinical internship. CMCC and UQTR ... Canadian Chiropractic Examining Board requires all candidates to complete a 12-month clinical intership to obtain licensure, as ...
Wyatt, Richard Jed; Chew, Robert H. (2008). Wyatt's Practical Psychiatric Practice: Forms and Protocols for Clinical Use. ...
MOMENTUM 3 IDE Clinical Study Protocol (HM3). U.S. National Institutes of Health. ClinicalTrials.gov. Retrieved September 16, ... is still in clinical trials for destination therapy. In a two-year randomized controlled clinical trial published in 2009 ... It began undergoing clinical trials in the U.S. and internationally in mid 2014. In mid 2014, CE Mark trials also started for ... It is cleared for clinical use up to six hours, and can be used as a short-term solution to support the circulation while ...
Spinifex Pharmaceuticals Pty Limited (2011). "CLINICAL STUDY PROTOCOL: Protocol No. EMA401-003". External link in ,title= (help ... Spinifex Pharmaceuticals Pty Limited (2011). "CLINICAL STUDY PROTOCOL: Protocol No. EMA401-003". External link in ,title= (help ... "CLINICAL STUDY PROTOCOL: Protocol No. EMA401-003". External link in ,title= (help) Andrew S C Rice; Robert H Dworkin; Tom D ... Phase I clinical trial also indicated EMA401 dose of up to 400 mg to be safe. Spinifex Pharmaceuticals reported the results of ...
A good clinical protocol will foresee these potential problems to ensure blinding is as effective as possible. It has also been ... Friedman, L.M., Furberg, C.D., DeMets, D.L. (2010). Fundamentals of Clinical Trials. New York: Springer, pp. 119-132. ISBN ... for example in clinical trials to evaluate the effectiveness of medicinal drugs and procedures without placebo effect, observer ...
Free clinical education programs are prehospital care, emergency department & hospital programs, and nursing school program. ... and embryo selection protocols. The research achievements from the Institute received both praise and criticism. The works have ...
Again, the clinical trial protocols specify the method of statistical analysis. Most clinical trials are analyzed using ... The data are analyzed using the statistical method that was specified in the clinical trial protocol, which needs to have been ... A crossover clinical trial is a repeated measures design in which each patient is assigned to a sequence of treatments, ... In a randomized clinical trial, the subjects are randomly assigned to different arms of the study which receive different ...
Clinical Research Protocols. A Phase III Randomized Double-Blind Study to Assess the Efficacy and Safety of Perifosine Plus ... Clinical Trials As part of our mission to eliminate cancer, MD Anderson researchers conduct hundreds of clinical trials to test ... Learn more about this clinical trial. A Phase I Study of Oral MK-2206 in Combination with Oral AZD6244 in Patients with Locally ... Learn more about this clinical trial. Phase I Oral MK_2206 w/AZD6244 w/Locally Advanced or Metastatic Solid Tumors (Dose ...
This volume details reviews and protocols on the development and analysis of both cellular and animal-based pre-clinical models ... Pre-Clinical Models. Book Subtitle. Techniques and Protocols. Editors. * Paul C. Guest ... Authoritative and cutting-edge, Pre-Clinical Models: Techniques and Protocols aims to provide methods that describe the context ... This volume details reviews and protocols on the development and analysis of both cellular and animal-based pre-clinical models ...
Standardised Protocols Would Greatly Enhance Clinical And Research Potential Of BTMs. by Sam Savage ... He also noted that standardised protocols would greatly increase the clinical and research potential of BTMs, with improved ... In clinical practice, BTMs are used to monitor osteoporosis treatment. BTMs generally show large and rapid responses to the ... IOF and IFCC experts recommend international reference standards for use of bone turnover markers in clinical studies ...
Posting of these protocols does not constitute endorsement of any specific protocol. We believe that each institution should ... Key Points Successful implementation of protocols requires: Buy-in from key stakeholders (critical care physicians, house staff ... consult with diabetes experts to select and implement insulin protocols. ... AACE Clinical Case Reports *Endocrine Practice - Journal *EmPower Magazine - For Patients *Advertising Opportunities *Clinical ...
Clinical Rescue Protocol - 2. The safety and scientific validity of this study is the responsibility of the study sponsor and ... Treatment effectiveness score as an outcome measure in clinical trials. NIDA Res Monogr. 1997;175:208-20. Review. ... and to determine if blood levels of methadone or buprenorphine correlate with clinical response. ...
Home » Policy & Compliance » Clinical Trials » Clinical Trials Protocol Template. Clinical Trials Protocol Template. Applicants ... the NIH and FDA collaboratively developed a Phase 2/3 Clinical Trial Protocol Template and an electronic protocol-writing tool ... To facilitate the development of clinical trial protocols that require a Food and Drug Administration (FDA) Investigational New ... NIH and FDA Release Protocol Template for Phase 2 and 3 IND/IDE Clinical Trials ...
... applied instruction to fundamental biochemistry methods and protocols, from buffer preparation... ... Protocols in Biochemistry and Clinical Biochemistry offers clear, ... Protocols in Biochemistry and Clinical Biochemistry offers clear, applied instruction to fundamental biochemistry methods and ... and clinical testing of vitamins, glucose and cholesterol levels, among other diagnostics. Each protocol is illustrated with ...
Screening for LID Clinical Studies Unit Healthy Volunteer Protocols. The safety and scientific validity of this study is the ... To accomplish this objective, up to 5000 participants will be enrolled in this protocol at the NIH Clinical Center clinic or ... The Laboratory of Infectious Diseases (LID) Clinical Studies Unit (CSU) enrolls healthy volunteers into clinical studies to ... NIH Clinical Center Detailed Web Page Publications: Anderson MJ, Heath RB. Cell mediated immunity in experimental influenza and ...
LINX Reflux Management System Clinical Study Protocol. The safety and scientific validity of this study is the responsibility ... Includes whether analysis was per protocol, intention to treat, or another method. Also provides relevant details such as ... Includes whether analysis was per protocol, intention to treat, or another method. Also provides relevant details such as ...
... new instruments and their related protocols enable the discovery or the improved characterization of bio-objects including ... nanovesicles within the 70-150nm diameter range that have recently aroused a great interest in the scientific and clinical ... Editorial: Tumor-Derived Extracellular Vesicles: Protocols, Models, and Clinical Evidence. Renaud Seigneuric1,2* and Carmen ... Tumor-Derived Extracellular Vesicles: Protocols, Models, and Clinical Evidence. The current frontiers in Oncology are at the ...
Underreporting of clinical research is wasteful and can result in biased estimates of treatment effect or harm, leading to ... Methods We assembled a cohort of clinical studies approved 2000-2002 by the Research Ethics Committee of the University of ... Commercial funding was mentioned in 203 (48%) protocols and in 205 (49%) of the publications. In most published studies (339; ... Of the started studies, 576 (71%) were completed according to protocol, 128 (16%) discontinued and 42 (5%) are still ongoing; ...
... a team of researchers at Lawson Health Research Institute and Western University have developed a new clinical protocol called ... New clinical protocol after general surgery cuts opioid prescribing in half. Lawson Health Research Institute ... A study demonstrating the efficacy of their protocol is being presented at the American College of Surgeons Clinical Congress ... a team of researchers at Lawson Health Research Institute and Western University have developed a new clinical protocol called ...
WHO finalized an international review of a breakthrough clinical protocol for HIV infection in Ukraine that will put the ... Health topics Communicable diseases HIV/AIDS Ukraine develops modern and progressive clinical protocol for HIV treatment ... Ukraine develops modern and progressive clinical protocol for HIV treatment 13-12-2017. WHO finalized an international review ... of a breakthrough clinical protocol for HIV infection in Ukraine that will put the country on the fast track to scaling up HIV ...
... ... 2.3 This Protocol does not-. (a) provide any detailed guidance to healthcare providers on clinical risk management or the ... Enforcement of the Protocol and sanctions. 1.7 Where either party fails to comply with this Protocol, the court may impose ... b) the Pre-Action Protocol for Personal Injury Claims;. (c) the Pre-Action Protocol for Low Value Personal Injury Claims in ...
This unit presents description of four basic clinical paradigms for clinical fMRI of language cmprehension, eye movement ( ... This unit presents description of four basic clinical paradigms for clinical fMRI of language cmprehension, eye movement ( ... Comprehensive MRI protocol for stroke management: Tissue sodium concentration as a measure of tissue viability in a non‐human ... primate model and clinical studies. Radiology 139:26‐34. Thulborn, K.R., Martin, C., and Voyvodic, J. 2000. fMRI using a ...
Protocols/Clinical Trials Active Studies. Protocol # Protocol Name Status. ACTG A5239. A Pilot Study of Therapy with ...
Part 1: Clinical Protocols Revised. 1. Current and Emerging Clinical Applications of the Auditory Steady-State Response (ASSR) ... Volume 1 primarily focuses on revised clinical protocols and provides information on new research to help guide decisions and ... 9. Clinical Applications of Frequency Following Response in Children and Adults. Milaine Dominici Sanfins, Stavros Hatzopoulos ... 8. Non-Conventional Clinical Applications of Otoacoustic Emissions: From Middle Ear Transfer to Cochlear Homeostasis to Access ...
A Randomized Prospective Clinical Trial Comparing Single Tooth Implant 3 Loading Protocols. The safety and scientific validity ... Clinical and radiographic screening will be used to limit the study to patients with sufficient bone quantity to completely ... This is a research study to test the clinical procedure and not the FDA approved medical device. This project will screen up to ... The subject will be given an informed consent for the study and reviewed with the clinical study coordinator. Preliminary ...
Institutional Review Board Review of Protocol and Informed Consent Changes ... Implementing Protocol Changes Affecting Subjects Already Enrolled in a Clinical Trial Prior to Obtaining IRB Approval As noted ... IRB Review of Protocol and Informed Consent Changes for NCI/CTEP-Sponsored Clinical Trials. September 29, 2008 ... regarding the implementation of changes to protocols and informed consent documents for NCI/CTEP-sponsored clinical trials in a ...
Institutional Review Board Review of Protocol and Informed Consent Changes ... Implementing Protocol Changes Affecting Subjects Already Enrolled in a Clinical Trial Prior to Obtaining IRB Approval As noted ... IRB Review of Protocol and Informed Consent Changes for NCI/CTEP-Sponsored Clinical Trials. September 29, 2008 ... HHS Home > OHRP > IRB Review of Protocol & Informed Consent Changes for NCI/CTEP-Sponsored Clinical Trials ...
CLINICAL FOCUS. * Hip fracture 1: identifying and managing risk factors This article, the first in a two-part series, offers a ... LATEST CLINICAL ARTICLE. * Hip fracture 1: identifying and managing risk factors This article, the first in a two-part series, ... LATEST CLINICAL ARTICLES. * Hip fracture 1: identifying and managing risk factors 10 December, 2018 12:42 pm ... An archive of around 6,000 peer-reviewed clinical articles. *A personal e-Portfolio to store and save CPD and revalidation ...
ICON Further Enhances Clinical Trial Feasibility, Protocol Optimisation And Patient Recruitment Capabilities With TriNetX. ICON ... TriNetX enables researchers to find the right patients at the right sites for clinical trials. For more information, visit http ... It follows ICONs application of cognitive computing capabilities to clinical trial feasibility and patient recruitment. ICONs ... The company specialises in the strategic development, management and analysis of programs that support clinical development - ...
The aim of this paper was to present structured rehabilitation protocols in two different patient groups with upper extremity ... The rehabilitation protocol for group 1 included guided sEMG training to facilitate initial movements, to increase awareness of ... The rehabilitation protocol for group 1 included guided sEMG training to facilitate initial movements, to increase awareness of ... The aim of this paper was to present structured rehabilitation protocols in two different patient groups with upper extremity ...
... protocols,would,greatly,enhance,clinical,and,research,potential,of,BTMs,biological,biology news articles,biology news today, ... In clinical practice BTMs are used to monitor osteoporosis treatment....In its position paper* the Joint IOF-IFCC Bone Marker ... Standardized protocols would greatly enhance clinical and research potential of BTMs. ...An expert working group of the ... Methods for gene transfer in stem cells featured in Cold Spring Harbor Protocols. 9. Cold Spring Harbor Protocols features RNA ...
Clinical management. * The Globalization of Clinical Data in Medtech * Noteworthy Clinical Trends in Med Device to Watch in ... In a clinical trial, if they differ from the investigational plan and havent been approved by the Sponsor, theyre protocol ... Anticipating Tensions Between Clinical Care and Study Protocol 3 October, 2017 Laurie Meehan, Social Media Manager; Polaris ... Clinical Solution Overview Clinical Management Trial Master File Trial Software Laboratory QMS TMF Checklist ...
  • To facilitate the development of clinical trial protocols that require a Food and Drug Administration (FDA) Investigational New Drug (IND) or Investigational Device Exemption (IDE) Application, the NIH and FDA collaboratively developed a Phase 2/3 Clinical Trial Protocol Template and an electronic protocol-writing tool to help investigators think through the scientific basis of their assumptions, minimize uncertainty in the interpretation of outcomes, and prevent loss of data. (nih.gov)
  • This study examines optic neuritis as a discrete central nervous system inflammatory event with measurable structural and clinical outcomes allowing the time-efficient (6 month) assessment of neuroprotective therapies. (bmj.com)
  • however these outcomes can be ameliorated when patients receive standardized care according to a clinical trial. (aacrjournals.org)
  • In the context of modest effects from most available physical therapy treatments for FS, this CNS-focused approach may lead to improved clinical outcomes. (medworm.com)
  • There were no clinically important differences in outcomes between the two protocols. (bmj.com)
  • Nurse-driven, protocol-directed weaning from mechanical ventilation improves clinical outcomes and is well accepted by intensive care unit physicians. (freecme.com)
  • A prospective study design was used to compare retrospective data from a specific 6-month period of physician-directed weaning outcomes with patient outcomes during a 6-month prospective period of the nurse-driven ventilator weaning protocol. (freecme.com)
  • Main outcomes for comparison included duration of mechanical ventilation (days), ICU length of stay, ventilator-associated pneumonia (VAP) rates, hospital mortality, and physician attitudes toward the nurse-managed protocol. (freecme.com)
  • The article by Danckers and colleagues reports on an innovative protocol that utilized the expertise of the ICU nursing staff to realize positive clinical outcomes for patients weaning from mechanical ventilatory support. (freecme.com)
  • In order to address the inconsistencies present, this project aims to determine a core set of outcomes which should be evaluated in all clinical trials of basal cell carcinoma. (biomedcentral.com)
  • This systematic review aims to ascertain the extent to which clinical outcomes in randomised trials of ACEi and ARBs are attributable to reductions in systolic BP. (biomedcentral.com)
  • Placebo and active comparator-controlled studies that report clinical outcomes, with greater than 500 person-years of follow-up in each study arm, will be included. (biomedcentral.com)
  • This systematic review will provide a detailed synthesis of evidence regarding the relationship between BP reduction and clinical outcomes with ACEi and ARBs. (biomedcentral.com)
  • Electroporation Protocols: Preclinical and Clinical Gene Medicine, Second Edition provides in-depth knowledge on the delivery of naked DNA and small-interfering RNA (siRNA) to the targeted cells, tissues, and animals for prevention and treatment of disease. (mexmat.ru)
  • Ibudilast's anti-neuroinflammatory and neuroprotective actions have been demonstrated in preclinical and clinical study results and provide the rationale for its potential therapeutic utility in neurodegenerative diseases (e.g., progressive MS and ALS), substance abuse/addiction and chronic neuropathic pain. (cnbc.com)
  • Clinical protocols for osteopathic manipulative treatment (OMT) procedures have been used in "technique" studies to examine the effects of specific procedures. (jaoa.org)
  • The randomized controlled trial design is considered to be the gold standard for clinical research and has been advocated for evaluating the benefits of alternative modes of therapy, 1 including osteopathic manipulative treatment (OMT). (jaoa.org)
  • Clinical endocrinologists worldwide rely on Endocrine Practice, the official journal of the American Association of Clinical Endocrinologists (AACE), to keep them on the leading edge of treatment of patients with endocrine diseases. (aace.com)
  • The purpose of this study is to detect increasing medication dose results in heroin cessation for patients still using, to determine if decreasing medication dose in patients unable to tolerate medication dose increases retention, and to determine if blood levels of methadone or buprenorphine correlate with clinical response. (clinicaltrials.gov)
  • Each data point in the TriNetX system can be traced to healthcare organisations who have the ability to identify individual patients, enabling ICON to develop virtual patient cohorts that can be found in real-world clinical trial settings. (thestreet.com)
  • ICON's ability to recruit patients is also strengthened through a wholly owned site network - PMG Research - with access to over 2 million active patient lives, as well as site partnerships with clinical research sites at healthcare systems and community physician practices all over the world. (thestreet.com)
  • TriNetX offers robust query and analytics tools that enable real-time analyses of patient populations which are helping our customers design better protocols, select the right sites and recruit patients faster. (thestreet.com)
  • TriNetX enables researchers to find the right patients at the right sites for clinical trials. (thestreet.com)
  • An exploratory study of the follow-up care needs of patients treated for colorectal cancer," Journal of Clinical Nursing , vol. 19, pp. 3291-3300, 2010. (hindawi.com)
  • Historically, we define patients as either fit for induction or unfit, and we made therapy decision largely based on those clinical factors. (ajmc.com)
  • The clinical experience of human immunodeficiency virus (HIV) + patients treated with oral atovaquone for acute Pneumocytstis carinii pneumonia (PCP) under a Treatment Investigational New Drug (IND) protocol (mild or moderate PCP) and an Open-Label Study protocol (severe PCP) was evaluated. (rti.org)
  • The European study, LINES 2009 (Low and Intermediate Risk Neuroblastoma European Study), groups together in a single protocol the treatment of all patients with "non high risk" neuroblastoma (NB), with stratification into two groups: low risk and intermediate risk. (centerwatch.com)
  • Everolimus Roll-over Protocol for Patients Who Have Completed a Previous Novartis-sponsored Everolimus Study. (centerwatch.com)
  • Open-label randomized clinical trial of 43 patients (60 eyes) who were 18 to 28 years of age and had progressive keratoconus and a plan to be treated with CXL at Umeå University Hospital, Umeå, Sweden. (diva-portal.org)
  • The patients were randomized to receive conventional CXL (n = 30) using the Dresden protocol or CXL with mechanical compression of the cornea using a flat rigid contact lens sutured to the cornea during the treatment (CRXL) (n = 30). (diva-portal.org)
  • Our goal is to build upon the body of clinical evidence for enzalutamide in an effort to help address the unmet needs of an even broader spectrum of prostate cancer patients. (astellas.com)
  • In this meta-analysis we assessed safety and clinical effectiveness of procalcitonin-based protocols to initiate or discontinue antibiotics in patients presenting with AECOPD. (bmj.com)
  • Methods Based on a prospectively registered protocol, we systematically reviewed the literature and selected randomised or quasi-randomised controlled trials comparing procalcitonin based protocols to initiate or discontinue antibiotics in patients presenting with AECOPD versus standard care. (bmj.com)
  • Conclusion Procalcitonin-based protocols to guide the administration of antibiotics in patients presenting with AECOPD appear safe and clinically effective. (bmj.com)
  • It is estimated that 20% of patients nationwide are eligible for a clinical trial, but only 3% are actually enrolled. (aacrjournals.org)
  • At the University of Chicago, almost 50% of new patients are eligible for a cancer clinical trial, but only 15% are enrolled. (aacrjournals.org)
  • 2) To determine clinical and simple laboratory indicators for diagnosis of patients with vaginal discharge in the local setting. (bmj.com)
  • Implementation of a nurse-driven protocol for weaning patients resulted in shortened duration of mechanical ventilation, shorter ICU stays, and a higher rate of successful weaning, with ICU physicians reporting a generally positive attitude toward nurses being responsible for protocol-directed weaning. (freecme.com)
  • Patients in the nurse-managed protocol period had weaning initiated more than 2 hours earlier when compared to the patients in the retrospective physician comparison group. (freecme.com)
  • Thus, the nurse-driven protocol was safe for ICU patients. (freecme.com)
  • Of the 76% of intensivists who completed the survey, their responses overall were a positive attitude toward the nurse-managed weaning protocol, including the earlier identification of patients ready to wean and the reduction in length of ventilatory support. (freecme.com)
  • Failure of bedside hospital clinical staff to follow established treatment protocols has been identified as a common factor in patients having an adverse event during their hospitalisation. (bmj.com)
  • Patients will be randomly allocated to receive either a standard anaesthesia protocol or an OFA. (bmj.com)
  • We defined a clinical diagnostic protocol for the uveitis, based on the frequency of syndromes found in the literature in each clinical pattern of uveitis and the symptoms of the patients. (bmj.com)
  • We believe that this is the first study in which a clinical protocol of diagnostic procedures has been validated in patients with uveitis. (bmj.com)
  • Two randomized double-blind clinical trials in patients with acute ischemic stroke have shown that treatment with a daily dose of 6 g acetaminophen (paracetamol) results in a small but rapid and potentially worthwhile reduction of 0.3°C (95% CI: 0.1-0.5) in body temperature. (pubmedcentralcanada.ca)
  • Paracetamol (Acetaminophen) In Stroke (PAIS) is a randomized, double-blind clinical trial, comparing high-dose acetaminophen with placebo in 2500 patients. (pubmedcentralcanada.ca)
  • We conducted two randomized, placebo-controlled clinical trials to study whether early treatment with acetaminophen reduces body temperature in patients with acute ischemic stroke confined to the carotid territory. (pubmedcentralcanada.ca)
  • Microbiologists at the SRC are using the ProtoCOL in conjunction with WASP automated spiral platers (Don Whitley Scientific, Shipley, UK), to rapidly process samples containing microorganisms taken from patients being treated with anti-microbial drugs and topical therapies. (selectscience.net)
  • One hundred twenty adult patients who fit the inclusion criteria are being recruited from the Peking University Hospital of Stomatology First Clinical Division (Beijing, China). (springer.com)
  • Introduction 24-hour ambulatory blood pressure monitoring (ABPM) is the gold standard diagnostic method for hypertension, but has some shortcomings in clinical practice while clinical settings often lack sufficient devices to accommodate all patients with suspected hypertension. (upc.edu)
  • NEW YORK and TOKYO, Aug. 22, 2018 /PRNewswire/ -- Pfizer Inc. (NYSE: PFE) and Astellas Pharma Inc. (TSE: 4503, President and CEO: Kenji Yasukawa, Ph.D., "Astellas") today announced amendments to the protocols for two registrational Phase 3 trials, ARCHES and EMBARK, designed to evaluate the safety and efficacy of XTANDI ® (enzalutamide) in men with hormone-sensitive prostate cancer (HSPC). (astellas.com)
  • The companies now anticipate the primary completion date for the ARCHES clinical trial to be in late 2018. (astellas.com)
  • Protocols in Biochemistry and Clinical Biochemistry offers clear, applied instruction to fundamental biochemistry methods and protocols, from buffer preparation to nucleic acid purification, protein, lipid, carbohydrate, and enzyme testing, and clinical testing of vitamins, glucose and cholesterol levels, among other diagnostics. (researchandmarkets.com)
  • Using data from eight Community Care Access Centres (CCACs) in Ontario, we demonstrate that an automatic, data-driven, machine learning algorithm such as the K nearest neighbors (KNN) algorithm can predict rehabil itation potential more effectively than the current Clini cal Assessment Protocol (CAP). (actapress.com)
  • Full clinical assessment including speculum examination and microbiological assessment for infection with gonorrhoea, chlamydia, candida, trichomonas, and bacterial vaginosis was performed on all women. (bmj.com)
  • Follow up assessment of clinical and microbiological response was performed 1-2 weeks later. (bmj.com)
  • Therefore, as part of a randomized clinical trial that examined OMT's effectiveness in boosting immunity in nursing home residents, this study included a poststudy survey to determine the effectiveness of the sham protocols to blind participants and to inquire into participants' assessment of their treatment protocol. (jaoa.org)
  • From the introduction: "Despite the push from various stakeholders in the health care system to standardized disease activity assessment in RA and growing evidence that treating to target is effective, most US rheumatologists do not routinely use standardized measures in clinical practice. (rawarrior.com)
  • A study demonstrating the efficacy of their protocol is being presented at the American College of Surgeons Clinical Congress in Boston, Massachusetts on October 24. (eurekalert.org)
  • The Phase 2 clinical program generated preliminary safety and efficacy data in approximately 100 people, half of whom received CSP-1103 for up to 2 years. (cnbc.com)
  • The present study has led to the development of a dynamic pre-clinical testing protocol to quantitatively assess the efficacy of disc replacement devices. (bl.uk)
  • Amiloride Clinical Trial In Optic Neuritis (ACTION) will utilise a multimodal approach to assess the neuroprotective efficacy of amiloride in acute ON. (bmj.com)
  • Recent clinical studies have evaluated the efficacy electric stimulation for treating OAB [ 13 ] However, a randomized controlled trial (RCT) for validation of the comparative efficacy and safety of acupuncture with electric stimulation as concurrent treatment has not yet been undertaken. (springer.com)
  • A recent paper ( doi:10.1038/sj.tpj.6500489 ) expands on the ethics of race-related research protocols in the context of the efficacy of Bidil, a cardiovascular drug, that works best in self-identified African-Americans. (wordpress.com)
  • Dr. Ken Leslie, scientist at Lawson, associate professor in the Department of Surgery at Schulich Medicine & Dentistry, and Chair/Chief of the Division of General Surgery at London Health Sciences Centre led the implementation of the new protocol. (eurekalert.org)
  • As you know, on March 20, 2008 CTEP issued a memorandum to NCI/CTEP-sponsored cooperative groups explaining implementation of revised CTEP procedures for handling amendments to cooperative group protocols and enrollment of new subjects in these protocols in situations in which new or modified risk information is considered to represent no more than a minor alteration in the overall risk-benefit relationship for subjects. (hhs.gov)
  • The nurses participated in protocol training and education sessions prior to implementation of the protocol, with a 1-month pilot period to gain familiarity with the protocol and to standardize communication with physicians. (freecme.com)
  • This trial is embedded in the national implementation and aims to assess the effectiveness of the eRegistry's interactive checklists and clinical decision support, compared with the existing paper based records, on improving the quality of care for pregnant women. (springermedizin.de)
  • This research topic aims at providing recent findings and reviews to contribute to the maturation of this emerging field with high clinical potential. (frontiersin.org)
  • Recognizing the role that opioid prescribing plays in the opioid crisis, a team of researchers at Lawson Health Research Institute and Western University have developed a new clinical protocol called STOP Narcotics. (eurekalert.org)
  • Volume 1 primarily focuses on revised clinical protocols and provides information on new research to help guide decisions and criteria regarding diagnosis, management, and treatment of hearing-related issues. (routledge.com)
  • This is a research study to test the clinical procedure and not the FDA approved medical device. (clinicaltrials.gov)
  • This 3 year research study will examine the clinical effects of loading regimens on roughened surfaced implants. (clinicaltrials.gov)
  • TriNetX is the worldwide health research network of healthcare organizations, biopharmaceutical companies and contract research organizations used to enhance clinical trial design and accelerate patient recruitment. (thestreet.com)
  • Standardized protocols would greatly enhance clinical and research potenti. (bio-medicine.org)
  • Therapeutic misconception - a well-documented phenomenon in clinical research - occurs when a study participant "fails to appreciate the distinction between the imperatives of clinical research and of ordinary treatment. (mastercontrol.com)
  • This is where well-trained clinical research assistants (CRAs) come in. (mastercontrol.com)
  • This study is a collaborative effort between MediciNova, Inc. and Drs. Nazem Atassi and Haruhiko Banno, Principal Investigators at Massachusetts General Hospital's (MGH) Neurological Clinical Research Institute (NCRI) and Harvard Medical School to measure the effects of MN-166 on reducing brain microglial activation utilizing a biomarker in 15 subjects with ALS. (cnbc.com)
  • There is a lack of clinical research and consensus regarding the effectiveness of various rehabilitation protocols for acute hamstring injuries in football. (bmj.com)
  • RESEARCH TRIANGLE PARK, NC --(Marketwired - December 18, 2014) - Today's strict regulatory environment necessitates that pharmaceutical companies adhere to clinical investigator fair market value (FMV) for trial-related compensation. (marketwired.com)
  • The Sunshine Act has changed how companies and trial managers pay clinical investigators," said Ryan McGuire, Head of Research at Cutting Edge Information. (marketwired.com)
  • To learn more about Cutting Edge Information's clinical investigator research and fair market value services, please visit http://cuttingedgeinfo.com/ . (marketwired.com)
  • A short, seven question, survey was distributed to all employees in the Section of Hematology/Oncology who were directly involved in clinical care or research. (aacrjournals.org)
  • Demonstrate and maintain knowledge of regulations, clinical research conduct, laws, guidelines and standards relating to department/trial(s). (americasjobexchange.com)
  • Synbiosis, a world-leading manufacturer of automated micro-biological systems, today announced its ProtoCOL automated colony counter is being successfully used by the Skin Research Centre (SRC) at the University of Leeds, one of Europe's leading dermatology centres, to rapidly test the effectiveness of new anti-microbial therapies to treat acne, dermatitis and other skin diseases. (selectscience.net)
  • Collette Lindley, Research Assistant at the SRC stated: "Our validated methods for clinical trials require a large throughput of growth media types and dilution replicates with up to 16 spiral plates for each subject for each study visit. (selectscience.net)
  • Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields. (omicsonline.org)
  • If we want to improve the depressing health metrics for our indigenous population, it is worth debating the value of race-related basic medical research and clinical trials. (wordpress.com)
  • Ethics and dissemination The protocol has been authorised by the research ethics committee of the Hospital Clinic of Barcelona (Ref. HCB/2014/0615): protocol details and amendments will be recorded and reported to ClinicalTrials.com. (upc.edu)
  • The recommendations will be taken into account during the WHO Regional Office for Europe-initiated revision of its 2007 HIV/AIDS clinical guidelines for the WHO European Region, based on revised global WHO recommendations on ART for adults and adolescents, ART for infants and children, use of ARVs for treatment of HIV-infected pregnant women and infants born to them. (who.int)
  • Conclusions Good compliance with UK guidelines for tryptase measurements is achievable in this long-term cohort, but obtaining clinical details at referral remains a challenge. (bmj.com)
  • Guidelines for clinical protocols for chronic lymphocytic leukemia: recommendations of the National Cancer Institute-sponsored working group. (semanticscholar.org)
  • In 2002, they published a pdf of clinical practice guidelines for RA which was updated in 2005. (rawarrior.com)
  • Health worker compliance with established best-practice clinical and public health guidelines may be enhanced by customized checklists of care and clinical decision support driven by point-of-care data entry into an electronic health registry. (springermedizin.de)
  • Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. (springer.com)
  • Based on the preceding discussion, the most important considerations with respect to the diagnosis of staphylococcal infections are (i) identification of staphylococci in clinical specimens, (ii) differentiation of S. aureus from the less-pathogenic CNS, and (iii) determination of whether isolates of either group are resistant to oxacillin. (asm.org)
  • 3 American Osteopathic Association (AOA) protocols for the use of OMT state that the "diagnosis must be specific. (jaoa.org)
  • Objectives To validate the efficiency of the application of a diagnostic protocol based on the patterns of presentation of uveitis to establish the diagnosis. (bmj.com)
  • Inclusion criteria are a clinical diagnosis of hemorrhagic or ischemic stroke and the possibility to start treatment within 12 hours from onset of symptoms. (pubmedcentralcanada.ca)
  • These findings are relevant not only for diagnosis in daily clinical routine, but also for treatment decisions and the definition of inclusion criteria in clinical trials. (arvojournals.org)
  • The aim of this scoping review is to summarize the existing literature on pulmonary angiosarcoma, particularly as it pertains to the clinical presentation and ancillary tests used for diagnosis in addition to histopathology. (biomedcentral.com)
  • This review will be valuable for highlighting the range of clinical presentations and the role of imaging and other diagnostic tools in the diagnosis of metastatic and primary pulmonary angiosarcoma. (biomedcentral.com)
  • Objective To compare the effectiveness of two rehabilitation protocols after acute hamstring injury in Swedish elite football players by evaluating time needed to return to full participation in football team-training and availability for match selection. (bmj.com)
  • OBJECTIVES: (1) To compare the effectiveness of two clinical protocols for the management of vaginal discharge in the situations where no laboratory facilities are available but speculum examination is possible and where basic laboratory facilities are available. (bmj.com)
  • The effectiveness of a health promotion with group intervention by clinical trial. (pubmedcentralcanada.ca)
  • A UK multi-centre, randomised, controlled trial for adults with recurrent tonsillitis to compare the clinical and cost-effectiveness of tonsillectomy versus conservative management. (biomedcentral.com)
  • The number of therapy days, adverse experiences, clinical response to therapy, and mortality were collected at day 21. (rti.org)
  • In addition, the results of this double-blinded clinical trial will shed new light on our understanding of acupuncture point specificity, and development of methodologies in clinical trials of acupuncture treatment. (nih.gov)
  • This volume details reviews and protocols on the development and analysis of both cellular and animal-based pre-clinical models in a number of medical areas, including metabolic disorders, longevity, cancer, heart disease and psychiatric disorders. (springer.com)
  • ICON's use of TriNetX is a further example of our commitment to deploy industry-leading technologies that help customers overcome complex clinical development challenges. (thestreet.com)
  • Additionally, the spine simulator and testing protocol would provide valuable data during the design stage of new total disc replacements, aiding the development of the next generation of artificial discs. (bl.uk)
  • We continually strive to design and implement clinical trials that bring innovations to people with the greatest need," said Steven Benner, M.D., senior vice president and global therapeutic area head, Oncology Development, Astellas. (astellas.com)
  • The report is a valuable resource for clinical development managers, directors and vice presidents to stay informed on the latest trends around determining clinical investigator FMV. (marketwired.com)
  • This document is intended as a guide to the protocol development for trials of prophylactic vaccines. (cdc.gov)
  • The template may serve phases I-IV clinical trials protocol development to include safety relevant information as required by the regulatory authorities and as deemed useful by the investigators. (cdc.gov)
  • On April 7, 2008 CTEP issued its first Action Letter under the revised CTEP procedures to investigators conducting CTEP/NCI-sponsored clinical trials involving the use of lapatinib (IND 70252). (hhs.gov)
  • It also examines common milestone payments, the number of payments made to clinical investigators and ranges and averages of direct costs that investigators often pass through to sponsors. (marketwired.com)
  • In addition, the investigators were wise to survey the intensivists who staff this ICU on their perceptions of the nurse-managed weaning protocol since they ultimately gave the "green light" to proceed with extubation. (freecme.com)
  • Although several investigators have shown that functional lung can be identified using advanced imaging techniques and/or demonstrated the feasibility and theoretical advantages of avoiding functional lung during radiotherapy, to our knowledge this premise has never been tested via a prospective randomized clinical trial. (biomedcentral.com)
  • Applicants conducting phase 2 or 3 clinical trials that require Investigational New Drug applications (IND) or Investigational Device Exemption (IDE) applications can use a NIH-FDA template with instructional and sample text to help write protocols. (nih.gov)
  • A cross-sectional observational study with repeated observations was conducted on 16 Danish dairy farms to quantify the influence of observer, parity, time (stage in lactation) and farm on variables routinely selected for inclusion in clinical protocols, thereby to enable a more valid comparison of udder health between different herds. (orgprints.org)
  • We improved the capacity of clinical-grade monocyte-derived dendritic cells to elaborate IL-12 with special regard of their state of maturation, different maturation stimuli and its regulation by TH1/TH2-influencing cytokines. (egms.de)
  • All investigated clinical-grade protocols for maturation of monocyte-derived DC appeared able to provide the phenotypic characteristics necessary to initiate DC maturation. (egms.de)
  • Conclusions A rehabilitation protocol emphasising lengthening type of exercises is more effective than a protocol containing conventional exercises in promoting time to return in Swedish elite football. (bmj.com)
  • CONCLUSIONS: Both protocols were equally effective in managing women with abnormal vaginal discharge. (bmj.com)
  • Conclusions Despite an organisational commitment to the RRS, clinical staff act on local cultural rules within the clinical environment that are usually not explicit. (bmj.com)
  • It is important to keep in mind that these algorithms have not been directly compared in clinical trials. (aace.com)
  • African-Americans are underrepresented amongst cancer clinical trial participants, despite evidence from our institution that African-Americans were more than twice as likely as Caucasians to enroll in a cancer clinical trial when offered. (aacrjournals.org)
  • The 2009 Cochrane review [ 3 ] identified only 1 evaluable adult trial with just 70 participants [ 4 ] followed up for only 90 days, and the review concluded that reasonable levels of evidence to support clinical decisions were only available for children. (biomedcentral.com)
  • An expert working group of the International Osteoporosis Foundation (IOF) and the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) has released a new position paper which reviews the evidence of bone turnover markers (BTMs) in fracture risk prediction and monitoring of osteoporosis therapy. (redorbit.com)
  • Considering that screening actions are the main source of evidence for detection of cervical cancer precursor lesions, it is necessary to build a protocol to be followed by nursing professionals during gynecological consultations. (scielo.br)
  • The proposed Phase 3 clinical trial is designed as an adequate and well controlled, double-blind, adaptive design, placebo-controlled multinational study of CSP-1103 administered to subjects with MCI due to AD who have biomarker evidence supporting this condition. (cnbc.com)
  • Dual antiplatelet therapy following percutaneous coronary intervention : clinical and economic impact of standard versus extended duration -- project protocol. (worldcat.org)
  • I thought you might be interested in this item at http://www.worldcat.org/oclc/1061002844 Title: Dual antiplatelet therapy following percutaneous coronary intervention : clinical and economic impact of standard versus extended duration -- project protocol. (worldcat.org)
  • In order to identify potential intervention strategies, we surveyed staff in the Section of Hematology/Oncology at the University of Chicago regarding clinical trial accrual. (aacrjournals.org)
  • The intervention tool is the eRegistry's interactive checklists and clinical decision support implemented within the District Health Information System 2 (DHIS2) Tracker software, developed and customized for the Palestinian context. (springermedizin.de)
  • Additional file 4: Standard Protocol Items: Recommendations for Intervention trials (SPIRIT) 2013 checklist: recommended items to address in a clinical trial protocol and related documents. (springermedizin.de)
  • Now a second clinical study will assess whether this reduced exposure is maintained over the longer term, and also whether longer term exposure reduction results in detectable changes in biological effect. (bio-medicine.org)
  • Total disc replacement has emerged as a viable treatment but the complexity of the spine is reflected in the clinical results, which trail far behind the success of hip and knee arthroplasty. (bl.uk)
  • Results Time to return was significantly shorter for the players in the L-protocol, mean 28 days (1SD±15, range 8-58 days), compared with the C-protocol, mean 51 days (1SD±21, range 12-94 days). (bmj.com)
  • The results of the study show a discrepancy between the absorbed dose-to-water determined according to TG-21 and TG-51 protocols of about 1.4% and 1.7% for 6 and 18 MV photon beams, respectively. (oregonstate.edu)
  • We divided the results into four categories, patient barriers, provider barriers, protocol barriers and health system barriers. (aacrjournals.org)
  • METHODS: Subjects were alternately allocated management according to one of two protocols: one without (group A) and one with (group B) immediate access to results of basic laboratory tests. (bmj.com)
  • Results 98% provided two or more acute samples, but only 60% supplied clinical information. (bmj.com)
  • This trial will compare the clinical and radiological results of three different techniques, and may contribute to better clinical decision making in the surgical treatment of LSS. (biomedcentral.com)
  • Your human subjects study may meet the NIH definition of a clinical trial. (nih.gov)
  • The primary objective of the study will be to evaluate the effects of CSP-1103 compared to placebo on clinical decline in subjects with MCI due to AD and who are also positive for amyloid β (Aβ) biomarker. (cnbc.com)
  • DESIGN: Alternate allocation of subjects to one of two management protocols. (bmj.com)
  • The authors recommended that sham protocols be used and that clinical trials assess the success of the sham protocols to blind subjects to group assignment. (jaoa.org)
  • The plate counts generated are then used to determine which treatments are the most effective at reducing the number of microorganisms associated with diseases on the skin of clinical trial subjects. (selectscience.net)
  • Methods Seventy-five football players with an acute hamstring injury, verified by MRI, were randomly assigned to one of two rehabilitation protocols. (bmj.com)
  • The survey queried respondents about their opinions on the current impediments to and facilitators of cancer clinical trial accrual at the University of Chicago as well as asking for their opinions on ways to improve the process. (aacrjournals.org)
  • MATERIALS AND METHODS This longitudinal human clinical trial is designed as a prospective study, to measure implant stability with the resonance frequency analyzer (Osstell, Integration Diagnostics AB, Sweden) at time of implant placement and up to 16 weeks post placement. (clinicaltrials.gov)
  • Study design Prospective randomised comparison of two rehabilitation protocols. (bmj.com)
  • The aim of this paper was to present structured rehabilitation protocols in two different patient groups with upper extremity nerve injuries using sEMG biofeedback. (frontiersin.org)
  • The rehabilitation protocol for group 1 included guided sEMG training to facilitate initial movements, to increase awareness of the new target muscle, and later, to facilitate separation of muscular activities. (frontiersin.org)
  • Feasibility of the rehabilitation protocols for the two different patient populations was illustrated. (frontiersin.org)
  • The primary objective of all rehabilitation protocols is to return the player as soon as possible to the prior level of performance with a minimal risk of injury recurrence. (bmj.com)
  • The goal of using a sham protocol is to control for the potentially therapeutic effects of touch and belief, which are components of the placebo effect. (jaoa.org)
  • The protocol for this new study has been approved by an independent ethics committee and is published in BioMed Central Public Health . (bio-medicine.org)
  • Moreover, it examines clinical measurement devices and reagents as utilized in hospitals, clinics, doctor's offices and at-home care locations. (prnewswire.co.uk)
  • However, for clinical specimens, such as blood, other fluids, or infected organ tissues, successful detection of viruses is less likely because virus-to-host genome ratios are insufficient ( 3 - 6 ). (cdc.gov)
  • In this study, we quantifiably and extensively compared classical and modern experimental approaches for virus purification and enrichment to finalize a protocol for unbiased detection of emerging viruses directly from organ tissues (tissue-based unbiased virus detection for viral metagenomics [TUViD-VM]) for an increased signal-to-noise ratio (ratio of virus genome to host genome) in virus detection. (cdc.gov)
  • Schematic description of tissue-based universal virus detection for viral metagenomics protocol. (cdc.gov)
  • Martin Smith for Synbiosis commented:" We are delighted so see the ProtoCOL being used routinely at such a major dermatology centre as the SRC. (selectscience.net)
  • It follows ICON's application of cognitive computing capabilities to clinical trial feasibility and patient recruitment . (thestreet.com)
  • An initial feasibility study comprises qualitative interviews to investigate the practicality of the protocol, including willingness to randomise and be randomised. (biomedcentral.com)
  • 1.3 It is important that each party to a clinical dispute has sufficient information and understanding of the other's perspective and case to be able to investigate a claim efficiently and, where appropriate, to resolve it. (justice.gov.uk)
  • Sponsors want this too, and can help sites do both these things by providing them a sufficient level of detail about protocol procedures as early as possible. (mastercontrol.com)
  • 1746 had sufficient clinical information to grade the reactions according to the Ring and Messmer scale. (bmj.com)