The reproductive organ (GONADS) in female animals. In vertebrates, the ovary contains two functional parts: the OVARIAN FOLLICLE for the production of female germ cells (OOGENESIS); and the endocrine cells (GRANULOSA CELLS; THECA CELLS; and LUTEAL CELLS) for the production of ESTROGENS and PROGESTERONE.
A complex disorder characterized by infertility, HIRSUTISM; OBESITY; and various menstrual disturbances such as OLIGOMENORRHEA; AMENORRHEA; ANOVULATION. Polycystic ovary syndrome is usually associated with bilateral enlarged ovaries studded with atretic follicles, not with cysts. The term, polycystic ovary, is misleading.
A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.
CELL LINE derived from the ovary of the Chinese hamster, Cricetulus griseus (CRICETULUS). The species is a favorite for cytogenetic studies because of its small chromosome number. The cell line has provided model systems for the study of genetic alterations in cultured mammalian cells.
An OOCYTE-containing structure in the cortex of the OVARY. The oocyte is enclosed by a layer of GRANULOSA CELLS providing a nourishing microenvironment (FOLLICULAR FLUID). The number and size of follicles vary depending on the age and reproductive state of the female. The growing follicles are divided into five stages: primary, secondary, tertiary, Graafian, and atretic. Follicular growth and steroidogenesis depend on the presence of GONADOTROPINS.
A genus of the family Muridae consisting of eleven species. C. migratorius, the grey or Armenian hamster, and C. griseus, the Chinese hamster, are the two species used in biomedical research.
The discharge of an OVUM from a rupturing follicle in the OVARY.
Supporting cells for the developing female gamete in the OVARY. They are derived from the coelomic epithelial cells of the gonadal ridge. Granulosa cells form a single layer around the OOCYTE in the primordial ovarian follicle and advance to form a multilayered cumulus oophorus surrounding the OVUM in the Graafian follicle. The major functions of granulosa cells include the production of steroids and LH receptors (RECEPTORS, LH).
A condition caused by the excessive secretion of ANDROGENS from the ADRENAL CORTEX; the OVARIES; or the TESTES. The clinical significance in males is negligible. In women, the common manifestations are HIRSUTISM and VIRILISM as seen in patients with POLYCYSTIC OVARY SYNDROME and ADRENOCORTICAL HYPERFUNCTION.
Pathological processes of the OVARY.
The degeneration and resorption of an OVARIAN FOLLICLE before it reaches maturity and ruptures.
The process of germ cell development in the female from the primordial germ cells through OOGONIA to the mature haploid ova (OVUM).
The flattened stroma cells forming a sheath or theca outside the basal lamina lining the mature OVARIAN FOLLICLE. Thecal interstitial or stromal cells are steroidogenic, and produce primarily ANDROGENS which serve as precusors of ESTROGENS in the GRANULOSA CELLS.
The major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is required in EMBRYO IMPLANTATION; PREGNANCY maintenance, and the development of mammary tissue for MILK production. Progesterone, converted from PREGNENOLONE, also serves as an intermediate in the biosynthesis of GONADAL STEROID HORMONES and adrenal CORTICOSTEROIDS.
A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Follicle-stimulating hormone stimulates GAMETOGENESIS and the supporting cells such as the ovarian GRANULOSA CELLS, the testicular SERTOLI CELLS, and LEYDIG CELLS. FSH consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity.
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.
Female germ cells derived from OOGONIA and termed OOCYTES when they enter MEIOSIS. The primary oocytes begin meiosis but are arrested at the diplotene state until OVULATION at PUBERTY to give rise to haploid secondary oocytes or ova (OVUM).
Gonadotropins secreted by the pituitary or the placenta in horses. This term generally refers to the gonadotropins found in the pregnant mare serum, a rich source of equine CHORIONIC GONADOTROPIN; LUTEINIZING HORMONE; and FOLLICLE STIMULATING HORMONE. Unlike that in humans, the equine LUTEINIZING HORMONE, BETA SUBUNIT is identical to the equine choronic gonadotropin, beta. Equine gonadotropins prepared from pregnant mare serum are used in reproductive studies.
The yellow body derived from the ruptured OVARIAN FOLLICLE after OVULATION. The process of corpus luteum formation, LUTEINIZATION, is regulated by LUTEINIZING HORMONE.
General term for CYSTS and cystic diseases of the OVARY.
A gonadotropic glycoprotein hormone produced primarily by the PLACENTA. Similar to the pituitary LUTEINIZING HORMONE in structure and function, chorionic gonadotropin is involved in maintaining the CORPUS LUTEUM during pregnancy. CG consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is virtually identical to the alpha subunits of the three pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity (CHORIONIC GONADOTROPIN, BETA SUBUNIT, HUMAN).
A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Luteinizing hormone regulates steroid production by the interstitial cells of the TESTIS and the OVARY. The preovulatory LUTEINIZING HORMONE surge in females induces OVULATION, and subsequent LUTEINIZATION of the follicle. LUTEINIZING HORMONE consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH and FSH), but the beta subunit is unique and confers its biological specificity.
The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids.
Hormones that stimulate gonadal functions such as GAMETOGENESIS and sex steroid hormone production in the OVARY and the TESTIS. Major gonadotropins are glycoproteins produced primarily by the adenohypophysis (GONADOTROPINS, PITUITARY) and the placenta (CHORIONIC GONADOTROPIN). In some species, pituitary PROLACTIN and PLACENTAL LACTOGEN exert some luteotropic activities.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Suspension or cessation of OVULATION in animals or humans with follicle-containing ovaries (OVARIAN FOLLICLE). Depending on the etiology, OVULATION may be induced with appropriate therapy.
The period of cyclic physiological and behavior changes in non-primate female mammals that exhibit ESTRUS. The estrous cycle generally consists of 4 or 5 distinct periods corresponding to the endocrine status (PROESTRUS; ESTRUS; METESTRUS; DIESTRUS; and ANESTRUS).
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
The period in the ESTROUS CYCLE associated with maximum sexual receptivity and fertility in non-primate female mammals.
Abnormally infrequent menstruation.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
A delta-4 C19 steroid that is produced not only in the TESTIS, but also in the OVARY and the ADRENAL CORTEX. Depending on the tissue type, androstenedione can serve as a precursor to TESTOSTERONE as well as ESTRONE and ESTRADIOL.
A neoplasm composed entirely of GRANULOSA CELLS, occurring mostly in the OVARY. In the adult form, it may contain some THECA CELLS. This tumor often produces ESTRADIOL and INHIBIN. The excess estrogen exposure can lead to other malignancies in women and PRECOCIOUS PUBERTY in girls. In rare cases, granulosa cell tumors have been identified in the TESTES.
Achievement of full sexual capacity in animals and in humans.
The male gonad containing two functional parts: the SEMINIFEROUS TUBULES for the production and transport of male germ cells (SPERMATOGENESIS) and the interstitial compartment containing LEYDIG CELLS that produce ANDROGENS.
Diminished or absent ability of a female to achieve conception.
A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEINIZING HORMONE from the PITUITARY GLAND. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to DIHYDROTESTOSTERONE or ESTRADIOL.
The hollow thick-walled muscular organ in the female PELVIS. It consists of the fundus (the body) which is the site of EMBRYO IMPLANTATION and FETAL DEVELOPMENT. Beyond the isthmus at the perineal end of fundus, is CERVIX UTERI (the neck) opening into VAGINA. Beyond the isthmi at the upper abdominal end of fundus, are the FALLOPIAN TUBES.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
The period of the MENSTRUAL CYCLE representing follicular growth, increase in ovarian estrogen (ESTROGENS) production, and epithelial proliferation of the ENDOMETRIUM. Follicular phase begins with the onset of MENSTRUATION and ends with OVULATION.
A glycoprotein that causes regression of MULLERIAN DUCTS. It is produced by SERTOLI CELLS of the TESTES. In the absence of this hormone, the Mullerian ducts develop into structures of the female reproductive tract. In males, defects of this hormone result in persistent Mullerian duct, a form of MALE PSEUDOHERMAPHRODITISM.
The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.
The fluid surrounding the OVUM and GRANULOSA CELLS in the Graafian follicle (OVARIAN FOLLICLE). The follicular fluid contains sex steroids, glycoprotein hormones, plasma proteins, mucopolysaccharides, and enzymes.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Euploid female germ cells of an early stage of OOGENESIS, derived from primordial germ cells during ovarian differentiation. Oogonia undergo MEIOSIS and give rise to haploid OOCYTES
Established cell cultures that have the potential to propagate indefinitely.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
A triphenyl ethylene stilbene derivative which is an estrogen agonist or antagonist depending on the target tissue. Note that ENCLOMIPHENE and ZUCLOMIPHENE are the (E) and (Z) isomers of Clomiphene respectively.
The capacity to conceive or to induce conception. It may refer to either the male or female.
Cell surface proteins that bind FOLLICLE STIMULATING HORMONE with high affinity and trigger intracellular changes influencing the behavior of cells.
The total process by which organisms produce offspring. (Stedman, 25th ed)
Techniques for the artifical induction of ovulation, the rupture of the follicle and release of the ovum.
A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
An enzyme that catalyzes the desaturation (aromatization) of the ring A of C19 androgens and converts them to C18 estrogens. In this process, the 19-methyl is removed. This enzyme is membrane-bound, located in the endoplasmic reticulum of estrogen-producing cells of ovaries, placenta, testes, adipose, and brain tissues. Aromatase is encoded by the CYP19 gene, and functions in complex with NADPH-FERRIHEMOPROTEIN REDUCTASE in the cytochrome P-450 system.
The surgical removal of one or both ovaries.
Compounds that interact with ANDROGEN RECEPTORS in target tissues to bring about the effects similar to those of TESTOSTERONE. Depending on the target tissues, androgenic effects can be on SEX DIFFERENTIATION; male reproductive organs, SPERMATOGENESIS; secondary male SEX CHARACTERISTICS; LIBIDO; development of muscle mass, strength, and power.
Proteins prepared by recombinant DNA technology.
Glycoproteins that inhibit pituitary FOLLICLE STIMULATING HORMONE secretion. Inhibins are secreted by the Sertoli cells of the testes, the granulosa cells of the ovarian follicles, the placenta, and other tissues. Inhibins and ACTIVINS are modulators of FOLLICLE STIMULATING HORMONE secretions; both groups belong to the TGF-beta superfamily, as the TRANSFORMING GROWTH FACTOR BETA. Inhibins consist of a disulfide-linked heterodimer with a unique alpha linked to either a beta A or a beta B subunit to form inhibin A or inhibin B, respectively
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
The active production and accumulation of VITELLINS (egg yolk proteins) in the non-mammalian OOCYTES from circulating precursors, VITELLOGENINS. Vitellogenesis usually begins after the first MEIOSIS and is regulated by estrogenic hormones.
Cessation of ovarian function after MENARCHE but before the age of 40, without or with OVARIAN FOLLICLE depletion. It is characterized by the presence of OLIGOMENORRHEA or AMENORRHEA, elevated GONADOTROPINS, and low ESTRADIOL levels. It is a state of female HYPERGONADOTROPIC HYPOGONADISM. Etiologies include genetic defects, autoimmune processes, chemotherapy, radiation, and infections.
The gamete-producing glands, OVARY or TESTIS.
The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
A mature haploid female germ cell extruded from the OVARY at OVULATION.
Single-stranded complementary DNA synthesized from an RNA template by the action of RNA-dependent DNA polymerase. cDNA (i.e., complementary DNA, not circular DNA, not C-DNA) is used in a variety of molecular cloning experiments as well as serving as a specific hybridization probe.
Hormones produced in the testis.
Compounds which increase the capacity to conceive in females.
Six-carbon alicyclic hydrocarbons which contain one or more double bonds in the ring. The cyclohexadienes are not aromatic, in contrast to BENZOQUINONES which are sometimes called 2,5-cyclohexadiene-1,4-diones.
PROGESTERONE-producing cells in the CORPUS LUTEUM. The large luteal cells derive from the GRANULOSA CELLS. The small luteal cells derive from the THECA CELLS.
The reproductive cells in multicellular organisms at various stages during GAMETOGENESIS.
A technique that localizes specific nucleic acid sequences within intact chromosomes, eukaryotic cells, or bacterial cells through the use of specific nucleic acid-labeled probes.
The female reproductive organs. The external organs include the VULVA; BARTHOLIN'S GLANDS; and CLITORIS. The internal organs include the VAGINA; UTERUS; OVARY; and FALLOPIAN TUBES.
An assisted reproductive technique that includes the direct handling and manipulation of oocytes and sperm to achieve fertilization in vitro.
A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precursors of certain vitamins, bile acids, alcohols (STEROLS), and certain natural drugs and poisons. Steroids have a common nucleus, a fused, reduced 17-carbon atom ring system, cyclopentanoperhydrophenanthrene. Most steroids also have two methyl groups and an aliphatic side-chain attached to the nucleus. (From Hawley's Condensed Chemical Dictionary, 11th ed)
Diminished or failed response of an organism, disease or tissue to the intended effectiveness of a chemical or drug. It should be differentiated from DRUG TOLERANCE which is the progressive diminution of the susceptibility of a human or animal to the effects of a drug, as a result of continued administration.
Preservation of cells, tissues, organs, or embryos by freezing. In histological preparations, cryopreservation or cryofixation is used to maintain the existing form, structure, and chemical composition of all the constituent elements of the specimens.
American Society of Clinical Oncology Resource-Stratified Clinical Practice Guideline". Journal of Global Oncology. 2 (5): 311- ... This attempts to surgically remove the cancer while preserving the ovaries and uterus, providing for a more conservative ... The Pap test was integrated into clinical practice in the Nordic countries in the 1960s. In Africa outcomes are often worse as ... Chicago, IL: American Society for Clinical Pathology Press. ISBN 978-0-89189-549-7. Garcia A, Hamid O, El-Khoueiry A (2006-07- ...
"The Clinical Advantages of 3D and 4D Ultrasound - Dr N Layyous". www.layyous.com. Retrieved 21 March 2018. Zare Mehrjardi, ... ovaries, and surrounding structures when appropriate Gestational age is usually determined by the date of the woman's last ... ovaries, and surrounding structures Evaluation of the fetal nuchal fold, with consideration of fetal nuchal translucency ... that there are clear reasons for this and that such scans are also clearly beneficial because ultrasound enables clear clinical ...
Gooren LJ (2011). "Clinical practice. Care of transsexual persons". N. Engl. J. Med. 364 (13): 1251-7. doi:10.1056/ ... such as due to polycystic ovary syndrome or congenital adrenal hyperplasia, in women As a component of hormone therapy for ... NSAAs are used in clinical medicine for the following indications: Prostate cancer in men Androgen-dependent skin and hair ... It reached phase II and phase III clinical trials for these indications prior to discontinuation due to insufficient ...
The ovaries connect to the fallopian tubes (oviducts), which serve to move the ovum from the ovary to the uterus. To do so, the ... Illustrated Atlas of Clinical Equine Anatomy and Common Disorders of the Horse Vol. II. Equistar Publication, Limited. ... The mare has two ovaries, usually 7 to 8 cm (2.8 to 3.1 in) in length and 3 to 4 cm (1.2 to 1.6 in) thick, that generally tend ... In equine ovaries, unlike in humans, the vascular tissue is cortical to follicular tissue, so ovulation can only occur at an ...
In that year clinical trial results in advanced melanoma were published in The New England Journal of Medicine. This was part ... It is recombinantly manufactured in Chinese hamster ovary (CHO) cells. Pembrolizumab was invented by scientists Gregory Carven ... Because the clinical trial was fairly small, Merck is obligated to conduct further post-marketing studies to ensure that the ... Results of a clinical trial in people with untreatable metastases arising from various solid tumors were published in Science ...
Since the mucus tends to pool at the bottom of the abdominal cavity, it is common to remove the ovaries, fallopian tubes, ... Pseudomyxoma peritonei (PMP) is a clinical condition caused by cancerous cells (mucinous adenocarcinoma) that produce abundant ... This disease is most commonly caused by an appendiceal primary cancer (cancer of the appendix); mucinous tumors of the ovary ... The standard of care for mucinous adenocarcinoma with clinical condition PMP involves cytoreductive surgery (CRS) with ...
In a clinical diagnosis, MRJP1 and MRJP2 are found to be the main allergens. They induce IgE-mediated hypersensitivity ... In the queen larva, MRJP1 seemed to induce faster growth, juvenile hormone secretion and development of ovary, while reducing ... Clinical and Experimental Allergy. 26 (2): 216-22. doi:10.1111/j.1365-2222.1996.tb00082.x. PMID 8835130. Hayashi T, Takamatsu N ...
Garg A (2011). "Clinical review#: Lipodystrophies: genetic and acquired body fat disorders". J. Clin. Endocrinol. Metab. 96 (11 ... hypertriglyceridemia and polycystic ovary syndrome in women. There is an increased risk of coronary heart disease. ... 2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 978-0-7216-2921-6. Herbst KL, Tannock LR, ...
... said women who drive risk damaging their ovaries and bearing children with clinical problems. Interior ministry employees had ... "Driving damages women's ovaries: Saudi cleric". Al Akhbar English. 29 September 2013. Archived from the original on 29 October ...
The testicles produce a much higher quantity than the ovaries. Conversion of testosterone to the more potent DHT occurs in ... The Journal of Clinical Endocrinology & Metabolism. 39 (2): 340-346. doi:10.1210/jcem-39-2-340. PMID 4278727. Scott F. Gilbert ... Androgens are synthesized in the testes, the ovaries, and the adrenal glands. Androgens increase in both males and females ... Regarding the relative contributions of ovaries and adrenal gland to female androgen levels, in a study with six menstruating ...
According to the National Institute for Health and Clinical Excellence (NICE) over 80 out of every 100 women aged under 40 who ... Nelson, S. M.; Telfer, E. E.; Anderson, R. A. (2012). "The ageing ovary and uterus: New biological insights". Human ... Apter D (February 1980). "Serum steroids and pituitary hormones in female puberty: a partly longitudinal study". Clinical ... ovarian reserve testing and its potential clinical implications". Human Reproduction Update. 20 (5): 688-701. doi:10.1093/ ...
Paul Goss a clinical ongologist and Mitch Dowsett a clinical chemist and made this possible. Further clinical development was ... In postmenopausal women the production of estrogen in the ovaries has ceased. The main source of estrogen is therefore ... Clinical studies have shown that 25 mg/day causes 97,9% suppression of aromatase. Estrogen plays a major part in the ... Clinical use of steroidal aromatase inhibitors today is more or less limited to exemestane. Use of formestane (Lentaron) is ...
Serving as voluntary clinical faculty, the medical school's physicians refused to jeopardize their practices in order to comply ... principal innovator of the first artificial human ovary. Other notable faculty include Peter A. Stewart, who developed a ... These sessions allow students to observe and practice clinical skills such as medical interviewing, history-taking, physical ... spending the first two basic medical science years at Dartmouth and the next two years in clinical education at Brown, where ...
Encyclopaedia of Clinical Toxicology: A Comprehensive Guide and Reference, by Irving S. Rossoff "Stories Of Old - Rona and the ... There are four stamens which extend slightly beyond the petal tube and the ovary is superior with 2 locules. Flowering occurs ...
A systematic review of clinical prediction rules for children with acute abdominal pain". Journal of Clinical Epidemiology. 66 ... the passing of an egg in the ovaries approximately two weeks before menstruation). Men: testicular torsion Adults: new-onset ... In children the clinical examination is important to determine which children with abdominal pain should receive immediate ... Pain medications (such as morphine) do not appear to affect the accuracy of the clinical diagnosis of appendicitis and ...
Lili went on to have four more subsequent operations that included an orchiectomy, an ovary transplant, a penectomy, and ... 2008). "Changes In Management Of Children With Differences Of Sex Development". Nature Clinical Practice Endocrinology & ... removal of ovaries and Fallopian tubes). For some trans women, facial feminization surgery, hair implants, and breast ... such as the testicles and the ovaries) in order to reduce their masculinizing or feminizing effects. Later, as surgical ...
The urinary bladder, uterus, fallopian tubes, and ovaries may be seen as either abdominal organs or as pelvic organs. Finally, ... Clinical Methods: The History, Physical, and Laboratory Examinations (3rd ed.). Boston: Butterworths. Retrieved 2013-11-27. ...
Although 6 to 7 million oocytes are present at mid-gestation in the human ovary, only about 500 (about 0.05%) of these ovulate ... Nishida N, Kudo M (2014). "Alteration of Epigenetic Profile in Human Hepatocellular Carcinoma and Its Clinical Implications". ... Journal of Clinical Oncology. 28 (2): 240-244. doi:10.1200/JCO.2009.24.2057. ISSN 1527-7755. PMC 3040011. PMID 19996028. Oktay ... The Journal of Clinical Endocrinology and Metabolism. 102 (10): 3839-3847. doi:10.1210/jc.2017-00765. ISSN 1945-7197. PMC ...
... is less common in female cats because progesterone is only released by the ovaries after mating. Also in cats, the ... Romagnoli, Stefano (2002). "Canine Pyometra: Pathogenesis, Therapy and Clinical Cases". Proceedings of the 27th World Congress ...
Polycystic ovaries can be viewed by the ultrasound, and it will show multiple, small cysts in the ovaries. Some symptoms that ... Wilcox G (May 2005). "Insulin and insulin resistance". The Clinical Biochemist. Reviews. 26 (2): 19-39. PMC 1204764. PMID ... The ovary also plays a vital role in releasing steroid hormones for follicular maturation and oocyte development. After the ... Increasing body weight is also thought to be linked to the development of polycystic ovary syndrome (PCOS). PCOS is a very ...
Clinical Trials". Retrieved 2018-11-11. "Sutton Disease 2 disease". Malacards - Research Articles, Drugs, Genes, Clinical ... The VPS13B gene is widely expressed, especially in prostate, testis, ovary, and colon with transcripts of about 12 to 14 ... "Ewing Sarcoma disease". Malacards - Research Articles, Drugs, Genes, Clinical Trials. Retrieved 2018-11-11. "Microcephaly ... disease". Malacards - Research Articles, Drugs, Genes, Clinical Trials. Retrieved 2018-11-11. Netherlands. "Disease #00139 - ...
This is a list of investigational hormonal agents, or hormonal agents that are currently under development for clinical use but ... polycystic ovary syndrome, and uterine fibroids [35] Linzagolix (KLH-2109, OBE-2109) - small-molecule GnRH receptor antagonist ...
An Endocrine Society Clinical Practice Guideline" (PDF). The Journal of Clinical Endocrinology & Metabolism. 94 (9): 3132-54. ... "Ovary function is preserved in transgender men at one year of testosterone therapy , Endocrine Society". www.endocrine.org. ... Journal of Clinical & Translational Endocrinology (2015)". Journal of Clinical & Translational Endocrinology. 2 (2): 55-60. doi ... "CORRIGENDUM FOR "Endocrine Treatment of Gender-Dysphoric/Gender-Incongruent Persons: An Endocrine Society Clinical Practice ...
Those mutations for which a homozygous form has not been described may be extremely rare, may result in clinical problems not ... polycystic ovary syndrome). Insulin resistance very rarely happens. Cystic kidney disease in patient or close relatives. Non- ... This page has previously claimed that MODY is equivalent to type 1 DM; however, the Oxford Handbook of Clinical Medicine states ... There are two general types of clinical presentation. Some forms of MODY produce significant hyperglycemia and the typical ...
Its scope covers basic, translational, clinical and experimental studies. The journal is published by Bioscientifica on behalf ... ovaries, and neuroendocrine system - and hormone-dependent cancers occurring elsewhere in the body. ... Endocrine-Related Cancer is abstracted and indexed in: CAB Abstracts Chemical Abstracts Current Contents (Clinical Medicine) ...
Maintz L, Novak N (May 2007). "Histamine and histamine intolerance". The American Journal of Clinical Nutrition. 85 (5): 1185- ... ovary, prostate, spinal cord, spleen, trachea and peripheral tissues. In the case of flawed HNMT activity, the organs which are ...
During her regular hospital treatment she discussed with doctors the advisability of an oophorectomy (removal of the ovaries), ... The Kathleen Ferrier Cancer Research Fund helped establish the Kathleen Ferrier Chair of Clinical Oncology at University ...
Females have two ovaries that store the eggs, and a uterus which is connected to a vagina. Males have testicles that produce ... The Journal of Clinical Investigation. 38 (7): 1065-77. doi:10.1172/JCI103883. PMC 293254. PMID 13664782. Fortney SM; Nadel ER ... Journal of Clinical Investigation. 110 (5): 615-624. doi:10.1172/JCI0215704. ISSN 0021-9738. PMC 151108. PMID 12208862. ...
The ovarian cortex is the outer portion of the ovary. The ovarian follicles are located within the ovarian cortex. The ovarian ... 60 reported live births brings the success and worldwide expansion of the technique towards routine clinical practice". Journal ... This article incorporates text in the public domain from the 20th edition of Gray's Anatomy (1918) "Cortex of ovary". The Free ...
Generally, the clinical findings are non-specific. Uterine adenosarcoma have, by definition, a malignant stroma and benign ... Ovary sparing surgery may be done in women wishing to preserve fertility. The prognosis is determined primarily by the cancer ...
The ovary: basic biology and clinical implications. JoAnne S. Richards1 and Stephanie A. Pangas2 1Department of Molecular and ... The ovary: basic biology and clinical implications JoAnne S. Richards et al. ... A Quantitative and Cytological Study of Germ Cells in Human Ovaries. Proc R Soc Lond B Biol Sci. 1963;158:417-433.. View this ... At this point, ovaries in Inha-/- mice are much larger and contain more advanced follicle types than those in wild-type mice. ...
Right: A cross section of a mouse ovary is shown, demonstrating the main cell types and follicle stages. Ovarian follicles are ... As we discuss here, mutant mouse models and clinical evidence indicate that some of the most powerful intra-ovarian regulators ... Copyright © 2017 American Society for Clinical Investigation ISSN: 0021-9738 (print), 1558-8238 (online) ... Summary of hormonal control of the ovary during follicle growth, ovulation, and luteinization. ...
Search of: Polycystic Ovary Syndrome: Clinical Trials - Modify Search. Fill in any or all of the fields below. Click on the ...
... this important text provides an overview of current knowledge of the polycystic ovary syndrome (PCOS) - its etiology, pathology ... Polycystic Ovary Syndrome. A Guide to Clinical Management, 1st Edition. Edited by Adam H. Balen, Gerard Conway, Roy Homburg, ... The Genetics of Polycystic Ovary Syndrome 6. Body Image and Quality of Life with Polycystic Ovary Syndrome 7. The Effects of ... focuses on clinical manifestations of disease, diagnostic criteria and options for management ...
Polycystic ovary syndrome (PCOS) is the most common cause of infertility in women, frequently becomes manifest during ... Definition, clinical features and differential diagnosis of polycystic ovary syndrome in adolescents. Author. Robert L ... Clinical manifestations of polycystic ovary syndrome in adults. *Comorbidities and complications of obesity in children and ... Epidemiology and clinical manifestations of Cushings syndrome. *Epidemiology and genetics of the polycystic ovary syndrome in ...
Diagnosis and treatment of polycystic ovary syndrome: an Endocrine Society clinical practice guideline.. Legro RS1, Arslanian ... The aim was to formulate practice guidelines for the diagnosis and treatment of polycystic ovary syndrome (PCOS). ... or polycystic ovaries). Establishing a diagnosis of PCOS is problematic in adolescents and menopausal women. Hyperandrogenism ...
... P. N. Shakuntala,1 K. Uma ... M. F. Aslam, C. Choi, and N. Khulpateea, "Neuroendocrine tumour of the ovary," Journal of Obstetrics and Gynaecology, vol. 29, ... C. F. Lindboe, "Large cell neuroendocrine carcinoma of the ovary," APMIS, vol. 115, no. 2, pp. 169-176, 2007. View at Publisher ... L. M. Roth, A. Tsubara, M. Dietel, and H. Senzaki, "Miscellaneous tumors and tumor-like conditions of the ovary," in Pathology ...
TGen is raising funds to start clinical trials to test these treatments. ... Small Cell Carcinoma of the Ovary, Hypercalcemic Type is a rare and aggressive cancer that typically strikes girls and young ... Small Cell Carcinoma of the Ovary, Hypercalcemic Type - Clinical Trials Fund. .BBFormSelectList{text-transform: capitalize;}. ... Today, we ask you to join our fight against ovarian cancer by supporting TGens Small Cell Ovarian Cancer Clinical Trial. ...
Polycystic Ovary Syndrome (PCOS): Clinical Aspects, Potential Complications and Dietary Management. Bruce Cobbs (Editor) ... Home / Shop / Books / Medicine and Health / Polycystic Ovary Syndrome (PCOS): Clinical Aspects, Potential Complications and ... Polycystic Ovary Syndrome (PCOS): Clinical Aspects, Potential Complications and Dietary Management quantity. ... Polycystic Ovary Syndrome (PCOS) is known as a common gynaecologic and endocrinology disease with multiple short and long-term ...
Clinical evaluation of a confocal microendoscope system for imaging the ovary Author(s): Anthony A. Tanbakuchi; Andrew R. Rouse ... We present initial clinical trial results using the device to image ovaries in-vivo using fluorescein and ex-vivo results using ...
Polycystic Ovary Syndrome , Hyperandrogenism , Ovarian Contribution to Androgen Production in Adolescent Girls ... Receive Emails About New Clinical Trials!. Sign up for our FREE service to receive email notifications when clinical trials are ... In women with PCOS, the majority of excess androgens are produced by the ovaries. However, it is unknown whether the ovaries ... Women with polycystic ovary syndrome (PCOS) can have unwanted facial or male-patterned body hair, irregular menstrual periods, ...
Polycystic Ovary Syndrome , Hyperandrogenemia , Etiological Factors of Obesity-Associated Hyperandrogenemia in Peripubertal ... Receive Emails About New Clinical Trials!. Sign up for our FREE service to receive email notifications when clinical trials are ... Subjects will be admitted to the General Clinical Research Center at 1600 h after 4 hours of fasting. We will measure ... A number of pathophysiological mechanisms underlie the polycystic ovary syndrome (PCOS). Neuroendocrine abnormalities play a ...
... electronic clinical resource tool for physicians and patients that provides information on Adult Primary Care and Internal ... of Epithelial carcinoma of the ovary, fallopian tube, and peritoneum: Clinical features and diagnosis. 12 ...
Evaluation of Clinical, Metabolic, Endocrine and Ultrasound Parameters. The safety and scientific validity of this study is the ... Costantino D, Minozzi G, Minozzi E, Guaraldi C. Metabolic and hormonal effects of myo-inositol in women with polycystic ovary ... Myo-inositol Versus D-chiro-inositol in the Treatment of Polycystic Ovary Syndrome and Insulin Resistance: ...
... ... Objectives: To describe the clinical and ultrasound features of fibroma and fibrothecoma of the ovary. ... Methods: Sixty-eight women with a histological diagnosis of fibroma or fibrothecoma of the ovary who had undergone a ...
Copyright © 2017 BMJ Publishing Group Ltd & Association of Clinical Pathologists. All rights reserved.. 京ICP备15042040号-3 ...
Kjøp boken Clinical Pathology of the Endocrine Ovary av J. (EDT) De Brux, J. P. (EDT) Gautrey, J. (EDT) De Brux (ISBN ... Clinical Pathology of the Endocrine Ovary av J. (EDT) De Brux, J. P. (EDT) Gautrey, J. (EDT) De Brux pocket, Engelsk, 2012 ...
Clinical and pathological observations on tumours of the ovary, fallopian tube, and broad ligament ?????? ??? ??? ???? ?????? ... Clinical and pathological observations on tumours of the ovary, fallopian tube, and broad ligament ?????? Alban Henry Griffiths ... Clinical and pathological observations on tumours of the ovary, fallopian tube, and broad ligament. 24568202 ... Clinical and Pathological Observations On Tumours of the Ovary, Fallopian Tube and Broad Ligament Doran Alban Henry ...
Metabolic and Endocrine Outcomes in Women with Polycystic Ovary Syndrome A Meta-Analysis of Randomized Controlled Trials. ... Patel, R. and Shah, G. (2017) Effect of Metformin on Clinical, Metabolic and Endocrine Outcomes in Women with Polycystic Ovary ... Polycystic Ovary Syndrome and the Role of Metformin in Ovulation Induction. Fabiana Fraga, Gabriel Azeredo César Salgado ... Compared with the control group, the expression of PGC1α in the ovaries of the mice in PCOS group was significantly increased ( ...
Clinical Anatomy of the Uterus, Fallopian Tubes, and Ovaries. Eric R. Sokol, MD. Assistant Professor of Obstetrics and ... At either end the ovary is supported by ligaments. At the tubal pole the ovary is attached to the suspensory ligament, a fold ... Photomicrograph (low power) of the cortex of the ovary of a human infant. The cortex of the ovary has numerous primordial germ ... Low magnification view of the pre-ovulation human ovary. The germinal epithelium of the ovary rests upon the ovarian stroma. ...
metformin, alone or in combination, in patients with polycystic ovary syndrome. A clinical entity at high risk for developing ... The hormonal, clinical and metabolic characteristics between the groups were homogeneous at the start of the study, except than ... Comparison of two doses of metformin (2.5 and 1.5g/day) for the treatment of polycystic ovary syndrome and their effect on body ... Blind, controlled and randomized clinical trial.. Patients. Women between 18 and 40 years of age, with a BMI ,20 and diagnosed ...
A Randomized Placebo-Controlled Double-Blind Clinical Trial.. Study Abstract. OBJECTIVES:. Polycystic ovary syndrome (PCOS), an ... In this randomized clinical trial, 84 PCOS subjects were randomly assigned to two groups; the treatment group received 1 g ... Adiponectin Receptors; Polycystic Ovary Syndrome; Quercetin. Study Information. Cell J. 2018 Jan;19(4):627-633. doi: 10.22074/ ... Oral Quercetin Supplementation Enhances Adiponectin Receptor Transcript Expression in Polycystic Ovary Syndrome Patients: ...
placebo combined with lifestyle modification in the treatment of polycystic ovary syndrome in obese women. Special attention ... However, the disparity of results in clinical studies cannot give us a conclusive answer if metformin is a new line therapy of ... Effects of insulin sensitizing drug metformin on clinical features, endocrine and metabolic profiles in obese women with ...
CCC is an intriguing histologic type of epithelial ovarian cancer that demonstrates a clinical behavior distinctly different ... Clinical characteristics of clear cell carcinoma of the ovary: a distinct histologic type with poor prognosis and resistance to ... Background: A retrospective review of treatment results comparing women with clear cell carcinoma of the ovary (CCC) with a ... Conclusions: CCC is an intriguing histologic type of epithelial ovarian cancer that demonstrates a clinical behavior distinctly ...
Copyright © 2017 BMJ Publishing Group Ltd & Association of Clinical Pathologists. All rights reserved.. 京ICP备15042040号-3 ...
Yolk sac tumour of ovary with fever and overt hypothyroidism: rare clinical presentation ... Yolk sac tumour of ovary with fever and overt hypothyroidism: rare clinical presentation ... Yolk sac tumour of ovary with fever and overt hypothyroidism: rare clinical presentation ...
Paclitaxel/Carboplatin + Galunisertib for Patients With Carcinosarcoma of the Uterus or Ovary. ... Rare Cancer News & Clinical Trials » Trial - Sarcoma » Paclitaxel/Carboplatin + Galunisertib for Patients With Carcinosarcoma ...
Women with polycystic ovary syndrome (PCOS) have an increased prevalence of insulin resistance (IR) and related disorders. ... Clinical significance of inflammatory markers in polycystic ovary syndrome: Their relationship to insulin resistance and Body ... Abstract: Background: Women with polycystic ovary syndrome (PCOS) have an increased prevalence of insulin resistance (IR) and ...
Your Name) has forwarded a page to you from Clinical Science Message Body (Your Name) thought you would like to see this page ... The polycystic ovary (PCO) syndrome (PCOS) is the most common cause of anovulatory infertility in women and is associated with ... C-type natriuretic peptide: a link between hyperandrogenism and anovulation in a mouse model of polycystic ovary syndrome. ... In a recent issue of Clinical Science (vol. 132, issue 7, 759-776), Wang and colleagues, highlight the important role of ...
... of peripheral benzodiazepine-binding sites in ovarian carcinomas as compared with benign ovarian tumours and normal ovaries ... Clinical Science. *Bioscience Reports. *Neuronal Signaling. *Biochemical Society Transactions. *Essays in Biochemistry ... of peripheral benzodiazepine-binding sites in ovarian carcinomas as compared with benign ovarian tumours and normal ovaries. ... benzodiazepine-binding sites in human epithelial ovarian carcinoma with those in benign ovarian tumours and normal ovaries. ...
  • Clearly presented and thoroughly up to date, this important text provides an overview of current knowledge of the polycystic ovary syndrome (PCOS) - its etiology, pathology, and the implications for effective medical management. (routledge.com)
  • Polycystic ovary syndrome (PCOS) is the most common cause of infertility in women [ 1 ], frequently becomes manifest during adolescence, and is primarily characterized by ovulatory dysfunction and hyperandrogenism. (uptodate.com)
  • The definition, clinical manifestations, and differential diagnosis of PCOS in adolescents are presented here. (uptodate.com)
  • The Androgen Excess and PCOS Society criteria for the polycystic ovary syndrome: the complete task force report. (uptodate.com)
  • Polycystic Ovary Syndrome (PCOS): A Guide for Teens. (uptodate.com)
  • The aim was to formulate practice guidelines for the diagnosis and treatment of polycystic ovary syndrome (PCOS). (nih.gov)
  • We suggest using the Rotterdam criteria for diagnosing PCOS (presence of two of the following criteria: androgen excess, ovulatory dysfunction, or polycystic ovaries). (nih.gov)
  • Polycystic Ovary Syndrome (PCOS) is known as a common gynaecologic and endocrinology disease with multiple short and long-term consequences. (novapublishers.com)
  • Chapter Three evaluates the available therapeutic strategies for the treatment of women with PCOS also focusing on diet in order to assess the possible impact on the clinical effects associated with it. (novapublishers.com)
  • Women with polycystic ovary syndrome (PCOS) can have unwanted facial or male-patterned body hair, irregular menstrual periods, or no menstrual periods excess body weight, and infertility. (centerwatch.com)
  • In women with PCOS, the majority of excess androgens are produced by the ovaries. (centerwatch.com)
  • In addition, determination of the sources of hyperandrogenemia across puberty may have clinical utility in the development of preclinical screening tests designed to reveal those girls at greatest risk for PCOS and identification of potential therapeutic targets to prevent its development. (centerwatch.com)
  • A number of pathophysiological mechanisms underlie the polycystic ovary syndrome (PCOS). (centerwatch.com)
  • Polycystic ovary syndrome (PCOS), an ovarian-pituitary axis androgen disorder, is a common endocrine disease in women. (wellnessresources.com)
  • Background: Women with polycystic ovary syndrome (PCOS) have an increased prevalence of insulin resistance (IR) and related disorders. (iospress.com)
  • The polycystic ovary (PCO) syndrome (PCOS) is the most common cause of anovulatory infertility in women and is associated with several clinical disorders. (clinsci.org)
  • In a recent issue of Clinical Science ( vol. 132, issue 7, 759-776 ), Wang and colleagues, highlight the important role of overactivated C-type natriuretic peptide (CNP) and natriuretic peptide receptor 2 (CNP/NPR2) system in preventing oocyte maturation and ovulation in PCOS mice model induced by androgen. (clinsci.org)
  • Polycystic ovary syndrome (PCOS) is heterogeneous in its clinical presentation and four major phenotypes have been identified. (pubmedcentralcanada.ca)
  • Since prenatal testosterone exposure is known to decrease the ratio of the second to fourth finger lengths (2D:4D), we characterized the left and right hand 2D:4D in women with clinical variants of PCOS. (pubmedcentralcanada.ca)
  • We hypothesized that if prenatal androgens were involved in the development of the phenotypic spectrum of PCOS, then lower 2D:4D would be differentially expressed among clinical variants of the syndrome. (pubmedcentralcanada.ca)
  • Digit ratios were determined in 98 women diagnosed with PCOS by the 2003 international consensus guidelines and in 51 women with regular menstrual cycles, no clinical or biochemical signs of hyperandrogenism and normal ovarian morphology. (pubmedcentralcanada.ca)
  • Women with PCOS were categorized into four clinical phenotypes (i.e. (pubmedcentralcanada.ca)
  • Left ( P = 0.77) and right ( P = 0.68) hand 2D:4D were similar among the four clinical phenotypes and no phenotype of PCOS demonstrated a 2D:4D that differed from controls (Left Hand, P = 0.44 and Right Hand, P = 0.75). (pubmedcentralcanada.ca)
  • Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder of unknown cause. (pubmedcentralcanada.ca)
  • In 2003, an international coalition of experts met to define the clinical spectrum of PCOS ( Rotterdam-Group, 2004a , b ). (pubmedcentralcanada.ca)
  • The result was a set of consensus criteria that defined PCOS as the presence of two of the following three symptoms: (i) oligo- or chronic-anovulation, (ii) clinical and/or biochemical hyperandrogenism and (iii) polycystic ovaries on ultrasonography. (pubmedcentralcanada.ca)
  • Polycystic ovary syndrome (PCOS) is the most common and highly complex endocrinopathy, which has obtained a great deal of importance in recent years owing to it being the most prevalent cause of anovulatory infertility. (ijpsonline.com)
  • The clinical signs and symptoms of PCOS also vary without a specific pattern among ethnic groups. (ijpsonline.com)
  • Polycystic ovary syndrome (PCOS) happens when a woman's ovaries or adrenal glands produce more male hormones than normal. (medlineplus.gov)
  • PCOS causes cysts (fluid-filled sacs) to grow on the ovaries. (medlineplus.gov)
  • What Are the Symptoms of Polycystic Ovary Syndrome (PCOS)? (medlineplus.gov)
  • How Do Health Care Providers Diagnose Polycystic Ovary Syndrome (PCOS)? (medlineplus.gov)
  • A health problem that involves ovarian cysts is polycystic ovary syndrome (PCOS). (medlineplus.gov)
  • The polycystic ovary syndrome (PCOS) is a common hyperandrogenic disorder and is characterized by a constellation of signs and symptoms often in association with a family history of hyperandrogenism and/or PCOS. (mysciencework.com)
  • To study whether a combination of berberine and letrozole results in higher live births than letrozole alone in infertile women with polycystic ovary syndrome (PCOS). (nih.gov)
  • OBJECTIVE -We investigated the relation between soluble CD36 (sCD36), risk markers of atherosclerosis and body composition, and glucose and lipid metabolism in polycystic ovary syndrome (PCOS). (diabetesjournals.org)
  • Polycystic ovary syndrome (PCOS) is characterized by anovulation, hyperandrogenemia, and/or polycystic ovaries. (diabetesjournals.org)
  • Abstract: Polycystic ovary syndrome (PCOS) is a common endocrine disorder. (nursingcenter.com)
  • POLYCYSTIC OVARY SYNDROME (PCOS) is a common endocrine, metabolic, and menstrual disorder in women. (nursingcenter.com)
  • 1 Stein and Leventhal first discussed PCOS in 1935 when patients presented with a host of endocrine issues, such as amenorrhea, polycystic ovaries, and hirsutism. (nursingcenter.com)
  • Polycystic Ovary Syndrome (PCOS) affects 15%-20% of adolescents and women of childbearing age. (advanceweb.com)
  • 4 Adolescents and women of childbearing age will visit numerous clinicians before being diagnosed with PCOS, and 50% to 75% of those adolescents and women will present to the primary care provider with already existing clinical manifestations of PCOS. (advanceweb.com)
  • 5 In adolescents and women of child bearing age, the most common diagnostic criteria used for PCOS are evidence of increased androgen levels, anovulatory symptoms such as amenorrhea, menorrhagia, oligomenorrhea, infertility, and/or polycystic ovaries. (advanceweb.com)
  • Polycystic ovary syndrome (PCOS) is one of the most frequently encountered endocrine disorders occurring in women of reproductive age. (oawhealth.com)
  • Polycystic ovary syndrome (PCOS) is a prevalent and frequently encountered endocrine disorder.1 It has been suggested that this condition occurs in as many as 4-10 percent of women of reproductive age,2 with onset manifesting as early as puberty.3 Because of the diversity of clinical and metabolic findings in PCOS, there has been great debate as to whether it represents a single disorder or multiple associated pathologic conditions. (oawhealth.com)
  • The ovaries and the adrenal glands contribute equally to testosterone production in women;15 however, in PCOS the main source of androgens is thought to come from the ovaries. (oawhealth.com)
  • At the present time, there are no clinical trials recruiting patients for focused ultrasound treatment of PCOS. (fusfoundation.org)
  • Polycystic ovary syndrome (PCOS) is a common endocrinopathy affecting approximately 5-10 % of reproductive-age women. (springer.com)
  • PCOS is widely accepted as a combination of ovulatory dysfunction, androgen excess, and polycystic ovaries with the exclusion of specific disorders that may lead to similar phenotypes. (springer.com)
  • Obesity and acanthosis nigricans are clinical features that are commonly seen in PCOS women and are associated with insulin resistance. (springer.com)
  • In this chapter, we will discuss the role of insulin resistance in the pathogenesis of PCOS, the risk of diabetes mellitus in this population, and the role of insulin-sensitizing agents, oral contraceptive pills, and antiandrogens in treating patients with polycystic ovary syndrome. (springer.com)
  • Although reports of disorders resembling PCOS date prior to the seventeenth century, the first clear description belongs to Chereau, who in 1844 described "sclerocystic degeneration of the ovaries. (springer.com)
  • 8 ] The modern era of PCOS began with a report by two gynecologists, Irving F. Stein and Michael L. Leventhal, who in 1935 described a syndrome of amenorrhea, hirsutism , and enlarged polycystic ovaries in anovulatory women. (springer.com)
  • The National Institutes of Health, Office of Disease Prevention, has described polycystic ovary syndrome (PCOS) as a major public health problem for women in the USA. (springer.com)
  • PCOS-related medical visits were identified using the International Classification of Diseases, 9th Revision, Clinical Modification code 256.4. (springer.com)
  • While the USA has made considerable advances in women's health, such as reductions in mortality from chronic diseases like breast cancer and cardiovascular disease, less progress has been made in the detection and treatment of polycystic ovary syndrome (PCOS). (springer.com)
  • 15 Issues contributing to the lack of diagnosis include differences in diagnosis, 15 particularly among health care providers from different specialties, 16 and misperceptions among patients and providers that cysts in the ovaries are a key feature of PCOS due to the condition's misleading name. (springer.com)
  • however, the presence of polycystic ovaries alone does not indicate that a woman has PCOS. (springer.com)
  • We're testing the safety and effectiveness of an investigational drug for women diagnosed with Polycystic Ovary Syndrome (PCOS). (mvclinical.com)
  • This Clinical Focus provides information on tests available for the differential diagnosis of polycystic ovary syndrome (PCOS) and the identification of common comorbidities. (questdiagnostics.com)
  • They published their observations in a landmark report [ 1 ] describing seven women who exhibited the triad of clinical symptoms - "polycystic" ovaries, hirsutism, and amenorrhea - associated with polycystic ovary syndrome (PCOS) to this day. (medscape.com)
  • Similarly, a woman with polycystic ovaries but no hormonal or metabolic aberrations does not have PCOS. (medscape.com)
  • Polycystic ovary syndrome (PCOS) is a hormonal disorder common among women of reproductive age. (mayoclinic.org)
  • Research has shown that women with PCOS have a type of low-grade inflammation that stimulates polycystic ovaries to produce androgens, which can lead to heart and blood vessel problems. (mayoclinic.org)
  • Polycystic ovary syndrome (PCOS) has recently been shown to affect a striking 12%-21% of Australian reproductive-age women, being more common among those who are overweight or of Indigenous background. (mja.com.au)
  • 1 , 12 The clinical presentation of PCOS is outlined in Figure 1. (mja.com.au)
  • Diagnosis of PCOS is now largely based on the Rotterdam criteria, 14 which are inclusive of the original National Institutes of Health (NIH) criteria 15 and require two of three key features: oligo- or anovulation, clinical and/or biochemical hyperandrogenism and polycystic ovaries on ultrasound (Figure 2). (mja.com.au)
  • Polycystic ovary syndrome (PCOS), one of the most common endocrine disorders encountered in women of reproductive age, is associated with an increased prevalence of metabolic syndrome (MetS). (tofjonline.org)
  • To study the distribution of anthropometric, clinical, and metabolic profiles of women with PCOS across the four regions of India. (tofjonline.org)
  • Palomba, S & La Sala, GB 2016, ' Menstrual preconditioning for the prevention of pregnancy complications in women with polycystic ovary syndrome (PCOS): Clinical opinion or viewpoint - This is the question ', American Journal of Obstetrics and Gynecology , vol. 214, no. 3, pp. 417-418. (elsevier.com)
  • Polycystic ovary syndrome (PCOS) is a complex condition with high risk for dyslipidemia, dysglycemia, venous thromboembolism, cardiovascular disease and metabolic syndrome. (biomedcentral.com)
  • The prevalence of polycystic ovary syndrome (PCOS) ranges from 5% to 22% in women of reproductive age worldwide. (biomedcentral.com)
  • PCOS includes a range of symptoms such as irregular menstrual cycle, trouble in getting pregnant, cyst formation in the ovaries, excessive body and facial hair, and pelvic pain, among others. (researchandmarkets.com)
  • Polycystic ovary syndrome (PCOS) is a common condition characterised by menstrual abnormalities and clinical or biochemical features of hyperandrogenism. (mja.com.au)
  • Interest in polycystic ovary syndrome (PCOS) has increased recently with the realisation that this syndrome involves far more than the reproductive system. (mja.com.au)
  • The diagnostic criteria for PCOS are controversial ( Box 1 ), but diagnosis is generally based on peripubertal onset of menstrual problems with clinical or biochemical hyperandrogenism. (mja.com.au)
  • Most publications on PCOS do not include the presence of polycystic ovaries as a diagnostic criterion. (mja.com.au)
  • Polycystic ovary syndrome (PCOS) is not a simple pathophysiologic process for which one treatment addresses all manifestations. (aafp.org)
  • The PCOS-associated insulin resistance and consequent hyperinsulinemia probably contribute to this effect by [1] stimulating androgen synthesis by the polycystic ovary (PCO) and [2] suppressing SHBG production in the liver. (unboundmedicine.com)
  • From the reviewed literature, there has been no population-based study that estimated the prevalence, clinical and/or biochemical characteristics of PCOS in Nigeria. (scirp.org)
  • To evaluate the clinical, hormonal and metabolic characteristics according to luteinizing hormone (LH)/follicle stimulating hormone (FSH) ratio in women with polycystic ovary syndrome (PCOS). (ogscience.org)
  • On the other hand, polycystic ovary syndrome (PCOS) is found in nearly 80% of women with hyperandrogenism and also in 8%-25% of normal ones. (scirp.org)
  • Women with Polycystic Ovary Syndrome (PCOS) have an increased level of sympathetic nerve activity, which was identified by Heart Rate Variability (HRV). (omicsonline.org)
  • PCOS is a state of ovulatory dysfunction in which there may also develop an abnormal ovary response to gonadotropins. (omicsonline.org)
  • Polycystic ovary syndrome (PCOS) is a condition characterized by the accumulation of numerous cysts (fluid-filled sacs) on the ovaries associated with high male hormone levels, chronic anovulation (absent ovulation), and other metabolic disturbances. (encyclopedia.com)
  • One of the most important characteristics of PCOS is hyperandrogenism, the excessive production of male hormones (androgens), particularly testosterone, by the ovaries. (encyclopedia.com)
  • Most, but not all, women with PCOS have multiple cysts on their ovaries. (encyclopedia.com)
  • It can be concluded from the present study that ultrasound scanning provide a non- invasive and accurate procedure for the assessment of ovarian morphology (specifically ovarian volume).Correlation of ovarian volume in women with polycystic ovary Hayfa Al- ShaheenBas J Surg, September, 12, 2006And when clinical diagnosis of PCOS was made, virtually all women were found to have characteristic ovarian morphology that extending from apparently normal to markedly enlarged cystic ovaries. (iasj.net)
  • Polycystic ovary syndrome (PCOS) in adolescent girls is usually related to hepato-visceral fat excess and insulin resistance, and associates with comorbidities such as type 2 diabetes. (bmj.com)
  • Treatment with a low-dose combination of one mixed antiandrogen and antimineralocorticoid (spironolactone), and two insulin sensitizers (pioglitazone/metformin) (SPIOMET) is particularly effective in improving the endocrine-metabolic derangements in adolescent girls with polycystic ovary syndrome (PCOS). (bmj.com)
  • Polycystic ovary syndrome, or PCOS, is the most common endocrine disorder in women of reproductive age. (wikipedia.org)
  • Infertility in polycystic ovary disease (PCOS) is a hormonal imbalance in women that is thought to be one of the leading causes of female infertility. (wikipedia.org)
  • Functional ovarian hyperandrogenism is usually the major source of the androgen excess [ 4-6 ] and can account for the major features of the syndrome, ie, hirsutism, anovulation, and polycystic ovaries [ 4,7 ]. (uptodate.com)
  • clinical and or biochemical hyperandrogenism (BH) and iii. (ijpsonline.com)
  • Polycystic ovaries are also found in women with no evidence of menstrual dysfunction or hyperandrogenism. (mja.com.au)
  • 5 , 6 While women with polycystic ovaries and no evidence of menstrual dysfunction or hyperandrogenism appear normal, they do have an overexaggerated response to stimulation with gonadotrophins such as follicle-stimulating hormone (FSH) in cycles of assisted reproduction. (mja.com.au)
  • In the ovary, the cardinal feature is functional hyperandrogenism ( Box 3 ). (mja.com.au)
  • An estimated prevalence of biochemical hyperandrogenism (BHA) was as high as 20.9% (88 women), while 3.6% (15 women) presented with clinical hyperandrogenism (CHA). (scirp.org)
  • Hyperandrogenism is exacerbated by obesity and is a key feature of polycystic ovary syndrome. (endocrineweb.com)
  • As we discuss here, mutant mouse models and clinical evidence indicate that some of the most powerful intra-ovarian regulators of follicular development include the TGF-β/SMAD, WNT/FZD/β-catenin, and RAS/ERK1/2 signaling pathways and the FOXO/FOXL2 transcription factors. (jci.org)
  • The ovary is a highly organized composite of germ cells (oocytes or eggs) and somatic cells (granulosa cells, thecal cells, and stromal cells) whose interactions dictate formation of oocyte-containing follicles, development of both oocytes and somatic cells as follicles, ovulation, and formation of the corpus luteum (the endocrine structure that forms from the ovarian follicle after ovulation and is required for establishing and maintaining pregnancy) (Figure 1 ). (jci.org)
  • Clinical features of ovarian large-cell neuroendocrine carcinoma: four case reports and review of the literature," Experimental and Therapeutic Medicine , vol. 2, no. 6, pp. 1083-1090, 2011. (hindawi.com)
  • As a result of this study, TGen has identified treatments that have shown astonishing results in preventing these ovarian tumors from growing in lab models, and we are ready to bring these therapies to a clinical trial. (tgen.org)
  • Today, we ask you to join our fight against ovarian cancer by supporting TGen's Small Cell Ovarian Cancer Clinical Trial. (tgen.org)
  • To determine the efficacy of sitagliptin alone or in combination with metformin in women with polycystic ovary in terms of ovarian cyclicity, fertility and cardiometabolic profile compared to metformin alone. (elsevier.es)
  • CCC is an intriguing histologic type of epithelial ovarian cancer that demonstrates a clinical behavior distinctly different from that of SAC. (nih.gov)
  • 2. In the present study we compared the binding characteristics of peripheral benzodiazepine-binding sites in human epithelial ovarian carcinoma with those in benign ovarian tumours and normal ovaries. (portlandpress.com)
  • The tested variables revealed that body mass index, waist/hip ratio, hirsutism, testosterone, insulin, ovarian volume and follicular count were elevated in polycystic ovary syndrome patients compared to the control subjects. (ijpsonline.com)
  • Increased testosterone levels, ovarian volume and antral follicular count or combination of these have been considered to be risk factors in developing polycystic ovary syndrome patients. (ijpsonline.com)
  • [2] Each ovary is whitish in color and located alongside the lateral wall of the uterus in a region called the ovarian fossa . (wikipedia.org)
  • The side of the ovary closest to the fallopian tube is connected to it by infundibulopelvic ligament , [3] and the other side points downwards attached to the uterus via the ovarian ligament . (wikipedia.org)
  • The ovaries lie within the pelvic cavity, on either side of the uterus, to which they are attached via a fibrous cord called the ovarian ligament . (wikipedia.org)
  • Ovarian cysts are fluid-filled sacs in or on an ovary. (medlineplus.gov)
  • After observing the restoration of menstruation following ovarian biopsies in patients with this syndrome, Stein and Leventhal performed one-half to three-fourths wedge resection of each ovary in seven women. (springer.com)
  • The patient underwent the surgical removal of the ovarian mass that was diagnosed by the pathologist as a giant mucinous cystadenoma of the ovary. (clinmedjournals.org)
  • 52 Granulosa cell tumor of the ovary is a rare type of ovarian cancer that accounts for approximately 2% of all ovarian tumors. (malacards.org)
  • Moreover, the disease could mimic ovarian cancer, as there are no specific symptoms and clinical signs. (hippokratia.gr)
  • Dissemination of ovarian cancer is a major clinical challenge and is poorly understood at the molecular level due to a lack of suitable experimental models. (pnas.org)
  • During normal development of the Drosophila ovary, a dynamic process called border cell migration occurs that resembles the migratory behavior of human ovarian cancer cells. (pnas.org)
  • In this study, we found that myosin VI, a motor protein that regulates border cell migration, is abundantly expressed in high-grade ovarian carcinomas but not in normal ovary and ovarian cancers that behave indolently. (pnas.org)
  • Ovarian cancer is the fifth major cause of cancer death among women in the U.S. Approximately 70% of ovarian cancer patients are diagnosed with disease that has spread beyond the ovaries ( 1 ). (pnas.org)
  • Myosin VI was found to be absent from normal ovary and expressed in ovarian cancers at levels that strongly correlated with the aggressiveness of clinical behavior. (pnas.org)
  • We compared clinical, hormonal and metabolic characteristics including age at menarche, body mass index (BMI), blood pressures, ovarian volume, and serum androgen levels between the two groups. (ogscience.org)
  • Clear cell carcinoma of the ovary is considered to be a specific subtype among the epithelial ovarian malignancies. (spandidos-publications.com)
  • From a complete series of 226 patients with epithelial ovarian carcinomas in FIGO stages I-II, 28 patients with clear cell carcinomas were selected and the clinical and biological characteristics of these tumors were compared with the remaining non-clear cell carcinomas. (spandidos-publications.com)
  • Clear cell carcinomas of the ovary should be regarded as a separate entity among the epithelial ovarian carcinomas and they differ with regard to both clinical and biological characteristics when compared with non-clear cell tumors. (spandidos-publications.com)
  • In this review we consider the pathology and clinical behavior of clear cell carcinoma and discuss the extent to which this impacts its management compared with other types of ovarian carcinoma. (bmj.com)
  • Ultrasound studies showed all women studied (100%) had altered ovarian morphology (both ovaries had multiple small cyst of (2-9mm), mean total follicular number (12.3±1.7) & thick capsule. (iasj.net)
  • Bilaterally enlarged ovaries were found in 84 (78.5%), mean (15.6± 2.04 cm3) and normal ovarian size were found in 23(21.5%) mean (6.6± 1.1 cm3). (iasj.net)
  • All patients who had enlarged ovaries were compared with those who had normal ovarian size regarding clinical and hormonal findings in order to determine a possible association between these findings and ovarian volume. (iasj.net)
  • Though surgery is not commonly performed, the polycystic ovaries can be treated with a laparoscopic procedure called "ovarian drilling" (puncture of 4-10 small follicles with electrocautery), which often results in either resumption of spontaneous ovulations or ovulations after adjuvant treatment with clomiphene or FSH. (wikipedia.org)
  • The Management of Infertility Associated with Polycystic Ovary Syndrome 14. (routledge.com)
  • Increased testosterone levels correlated positively with luteinizing hormone/follicle-stimulating hormone ratio (p=0.023), hirsutism (p=0.001) and antral follicular count (p=0.004) in polycystic ovary syndrome patients in the studied population. (ijpsonline.com)
  • Hyperandrogenemia (elevated free testosterone , free androgen index, or DHEA levels) and/or clinical evidence of androgen excess (hirsutism, acne, clitoromegaly, male body habitus) are present in up to 80% of affected women. (medscape.com)
  • The ovaries produce abnormally high levels of androgen, resulting in hirsutism and acne. (mayoclinic.org)
  • This randomized clinical trial included 60 polycystic ovary syndrome patients with hirsutism who were referred to infertility and reproductive health research center and governmental public educational hospital from Feb2007 till Dec 2007. (clinicaltrials.gov)
  • Insulin-sensitizing agents are indicated for most women with polycystic ovary syndrome because they have positive effects on insulin resistance, menstrual irregularities, anovulation, hirsutism, and obesity. (aafp.org)
  • Physical examination includes a pelvic examination to determine the size of the ovaries, and visual inspection of the skin for hirsutism, acne, or other changes. (encyclopedia.com)
  • Large cysts develop in the ovaries which often produce high levels of oestrogen. (thepigsite.com)
  • Cysts 2-3cm in diameter in the ovaries, filled with clear fluid. (thepigsite.com)
  • Increased androgen levels cause a decrease in progesterone and estrogen, leading to a hypersecretion of gonadotropic-releasing hormone (GnRH) and luteinizing hormone (LH) levels, which continues to stimulate immature follicles which do not mature and form cysts in the ovary. (advanceweb.com)
  • Luteal cystic ovary disease is characterized by enlarged ovaries with one or more cysts, the walls of which are thicker than those of follicular cysts because of a lining of luteal tissue. (merckvetmanual.com)
  • Luteal cysts are recognized as smooth, fluctuant domes protruding above the surface of the ovary. (merckvetmanual.com)
  • Because of poor estrus detection practices on many dairy farms, the treatment of choice for both follicular and luteal cysts is intravaginal progesterone /prostaglandin (a fixed timed artificial insemination protocol) (see Treatment of Follicular Cystic Ovary Disease in Large Animals). (merckvetmanual.com)
  • Polycystic ovaries are characterised by peripheral cysts (10 or more) less than 10 mm in size in an enlarged ovary with significant increase in the central stroma 4 ( Box 2 ). (mja.com.au)
  • The right ovary was removed, measured 15 cm in maximum dimension, and contained multiple cysts which on microscopic examination had the typical morphology of follicle cysts. (medworm.com)
  • The case represents an example of multiple luteinized follicle cysts, analogous to the phenomenon seen occasionally in pregnancy, but with a different clinical background. (medworm.com)
  • The syndrome is named after the characteristic cysts which may form on the ovaries, though it is important to note that this is a symptom and not the underlying cause of the disorder. (wikipedia.org)
  • Summary of hormonal control of the ovary during follicle growth, ovulation, and luteinization. (jci.org)
  • Clinical, hormonal and metabolic basal features by treatment group. (elsevier.es)
  • The objective of this study was to evaluate and compare the clinical, biochemical, hormonal and gynecological aspects of polycystic ovary syndrome at a hospital in South India. (ijpsonline.com)
  • Clinical history and biochemical and hormonal analysis were carried out. (ijpsonline.com)
  • Updating and expanding his highly praised Hormone Replacement Therapy (Humana Press, 1999), A. Wayne Meikle, MD, brings together in Endocrine Replacement Therapy in Clinical Practice the extensive knowledge of leading clinicians in managing children and adults in need of hormonal replacement therapy. (bookdepository.com)
  • Polycystic ovary syndrome market is a hormonal disorder observed in females of reproductive ages. (researchandmarkets.com)
  • Inappropriate gonadotropin secretion in polycystic ovary syndrome: The relationship with clinical, hormonal and metabolic characteristics. (ogscience.org)
  • Correlationn of the ultrasonic PCO-like multicystic ovaries with clinical, hormonal and ultrasonic findings. (ogscience.org)
  • Comparing these hormonal levels between women who had enlarged ovaries and those who had normal- sized ovaries we found that serum testosterone, LH & LH/FSH ratio were significantly higher in women who had enlarged ovaries. (iasj.net)
  • polycystic ovaries on ultrasound. (ijpsonline.com)
  • The presence of polycystic ovaries on ultrasound examination is particularly controversial as a criterion. (mja.com.au)
  • The purpose of this study is to determine how the ovaries contribute to the production of male hormones in the body during different stages of puberty, so that it can be better understood why some females have excess androgens. (centerwatch.com)
  • However, the ability of the ovaries to produce androgens (e.g., to respond to gonadotropin stimulation) during early puberty has not been tested concurrently in these girls. (centerwatch.com)
  • The theca cells, which envelop the follicle and produce androgens for conversion in the ovary to oestrogen, are over-responsive to this stimulation. (mja.com.au)
  • Patel, R. and Shah, G. (2017) Effect of Metformin on Clinical, Metabolic and Endocrine Outcomes in Women with Polycystic Ovary Syndrome A Meta-Analysis of Randomized Controlled Trials. (scirp.org)
  • They also have increased prevalence of cardiovascular risk factors similar to that seen in the metabolic syndrome (which, like polycystic ovary syndrome, is characterised by insulin resistance 4 ). (bmj.com)
  • But to date, experts haven't been able to agree on a new name for this syndrome that adequately represents its anatomic, clinical, and metabolic manifestations. (medscape.com)
  • TY - JOUR T1 - Ovulatory and metabolic effects of D-chiro-inositol in the polycystic ovary syndrome. (unboundmedicine.com)
  • Receive Emails About New Clinical Trials! (centerwatch.com)
  • Sign up for our FREE service to receive email notifications when clinical trials are posted in the medical category of interest to you. (centerwatch.com)
  • Selection of studies 13 trials were included for analysis, including 543 women with polycystic ovary syndrome that was defined by using biochemical or ultrasound evidence. (bmj.com)
  • 6 - 11 This review aims to answer the question whether metformin is effective in treating women with polycystic ovary syndrome, by amalgamating the trials whose methods are of the highest quality so that meta-analysis can produce valid results. (bmj.com)
  • We included randomised controlled trials of metformin compared with placebo, no treatment, or ovulation inducing agents in women with polycystic ovary syndrome. (bmj.com)
  • We included trials only if polycystic ovary syndrome was defined by using biochemical or ultrasound evidence. (bmj.com)
  • Carefully conducted clinical trials are the safest and fastest way to find effective treatments, and new ways to improve health. (rochester.edu)
  • GervanoRA's Clinical trials report "Polycystic Ovary Duodenal Ulcer: Comprehensive Global Clinical Trials Analytics H2 2018" provides an in-depth analysis of the overall clinical trials for Polycystic Ovary Duodenal Ulcer. (gervanora.com)
  • The report caters information related to the global clinical trials with respect to their Phase, Trial Status, Intervention, Trial type and Endpoint status. (gervanora.com)
  • The report offers coverage of Polycystic Ovary Duodenal Ulcer clinical trials by region and average enrollment by country. (gervanora.com)
  • Country based analytics are provided according to the Top 5 Clinical trial sites globally and the emerging countries supporting with a platform to conduct clinical trials effectively. (gervanora.com)
  • Analytics are also provided for the subjects enrolled over a period of time, Polycystic Ovary Duodenal Ulcer clinical trials by sponsor type and the top companies involved in the R&D of Polycystic Ovary Duodenal Ulcer drug development. (gervanora.com)
  • In addition, the report gives a brief overview on the major drugs undergoing trials and the recent advancements observed in the Polycystic Ovary Duodenal Ulcer clinical trials. (gervanora.com)
  • Improved specificity of the histological definition of this tumor type is helping these efforts but, due to the rarity of clear cell carcinoma, international collaboration will be essential to design appropriately powered, large-scale clinical trials. (bmj.com)
  • Have a question about clinical trials? (lvhn.org)
  • A retrospective review of treatment results comparing women with clear cell carcinoma of the ovary (CCC) with a group with serous adenocarcinoma of the ovary (SAC) was conducted. (nih.gov)
  • This case report describes symptomatic hypercalcemia as the presenting sign of mixed serous and clear cell carcinoma of the ovary. (thepermanentejournal.org)
  • Clear cell carcinoma of the ovary has distinct biology and clinical behavior. (bmj.com)
  • Dehydroepiandrosterone (DHEA) treatment caused anovulation, high levels of androgen and estrogen receptors (AR and ER) in the ovary, high expression of CNP and natriuretic peptide receptor 2 (NPR2) in granulosa cells (GC), and an increase in testosterone and estradiol (E 2 ) levels in sera. (clinsci.org)
  • Conclusions Metformin is an effective treatment for anovulation in women with polycystic ovary syndrome. (bmj.com)
  • Should obese women with polycystic ovary syndrome receive treatment for infertility? (bmj.com)
  • Balen Adam H , Dresner Martin , Scott Eleanor M , Drife James O . Should obese women with polycystic ovary syndrome receive treatment for infertility? (bmj.com)
  • L. M. Roth, A. Tsubara, M. Dietel, and H. Senzaki, "Miscellaneous tumors and tumor-like conditions of the ovary," in Pathology and Genetics of Tumors of the Breast and Female Genital Organs , F. A. Tavassoli and P. Devilee, Eds. (hindawi.com)
  • Diagnosis and treatment of polycystic ovary syndrome: an Endocrine Society clinical practice guideline. (nih.gov)
  • It is also the average age of diagnosis for small cell carcinoma of the ovaries hypercalcemic type (SCCOHT) - a highly aggressive tumor that kills more than 65 percent of patients within two years of initial diagnosis. (tgen.org)
  • Sixty-eight women with a histological diagnosis of fibroma or fibrothecoma of the ovary who had undergone a preoperative ultrasound examination between 1999 and 2007 were identified from the databases of four ultrasound centers. (nih.gov)
  • Clinical laboratories play a vital role in the healthcare industry as about 80% of the clinician's diagnoses are based on laboratory analysis with a range of tests carried out on clinical specimens, to obtain information about the health of a patient to aid in diagnosis, treatment and prevention of disease. (news-medical.net)
  • The simultaneous presence of adenocarcinoma and echinococcosis in the same ovary is extremely rare and little data exist regarding diagnosis and treatment approach. (hippokratia.gr)
  • Management of infertility in polycystic ovary syndrome includes lifestyle modification as well as assisted reproductive technology such as ovulation induction, oocyte release triggering and surgery. (wikipedia.org)
  • When the oocyte finishes its maturation in the ovary, a surge of luteinizing hormone secreted by the pituitary gland stimulates the release of the oocyte through the rupture of the follicle, a process called ovulation . (wikipedia.org)
  • They usually form during ovulation, when the ovary releases an egg. (medlineplus.gov)
  • Results Meta-analysis showed that metformin is effective in achieving ovulation in women with polycystic ovary syndrome, with odds ratios of 3.88 (95% confidence interval 2.25 to 6.69) for metformin compared with placebo and 4.41 (2.37 to 8.22) for metformin and clomifene compared with clomifene alone. (bmj.com)
  • 5 , 6 As polycystic ovaries arise through incomplete follicular development or failure of ovulation, they may also occur in early to mid-adolescence, and in women with bulimia, recovery from anorexia nervosa, conditions of increased adrenal androgen production and hyperprolactinaemia. (mja.com.au)
  • Expression and regulation of high mobility group AT-hook 1 (HMGA1) during ovulation and luteinisation in rat ovary. (medworm.com)
  • The Fluctuation in the Heart Rate Variability Throughout Ovulation Induction Cycle: Is the Case Different in Polycystic Ovary Syndrome? (omicsonline.org)
  • A 66-year-old Greek Caucasian woman of rural origin, para 2, gravid 4, was referred from a district regional hospital to the gynecologic oncology department of Theagenio Cancer hospital, for further evaluation, due to the presence of a 10 x 12 x 12 cm, palpable, cystic mass found in the anatomical region of the left ovary. (hippokratia.gr)
  • Clinical examination showed a palpable mass at the anatomical site of the left ovary. (hippokratia.gr)
  • Transvaginal ultrasound scan was not satisfactory due to the large size of the tumor, while abdominal ultrasound revealed the presence of a 12 cm diameter cystic mass with echogenic elements localized in the anatomical site of the left ovary. (hippokratia.gr)
  • The left ovary was grossly similar intraoperatively. (medworm.com)
  • Subsequent excision of the pituitary adenoma was followed ∼3 mo later by a return to normal size of the left ovary. (medworm.com)
  • Most patients have one or more clinical features of the insulin-resistant state. (medscape.com)
  • Women with the polycystic ovary syndrome have insulin resistance and hyperinsulinemia, possibly because of a deficiency of a D-chiro-inositol-containing phosphoglycan that mediates the action of insulin. (unboundmedicine.com)
  • D-Chiro-inositol increases the action of insulin in patients with the polycystic ovary syndrome, thereby improving ovulatory function and decreasing serum androgen concentrations, blood pressure, and plasma triglyceride concentrations. (unboundmedicine.com)
  • The number of references citing insulin resistance in polycystic ovary syndrome has risen steadily since 1988, when the first of articles on the topic appeared. (endocrineweb.com)
  • In 2013, Dr. Teede and colleagues reported on the prevalence of insulin resistance and contributions of intrinsic and extrinsic insulin resistance in women diagnosed with polycystic ovary syndrome according to the Rotterdam criteria. (endocrineweb.com)
  • Using a cross-sectional design, 20 overweight and 20 lean patients, 14 overweight and 19 lean matched controls without the syndrome underwent clinical measures of insulin resistance after a 3-month withdrawal of insulin sensitizers and the oral contraceptive pill. (endocrineweb.com)
  • 001). Insulin resistance was present in 75% of lean patients with polycystic ovary syndrome, 62% of overweight controls, and 95% of overweight patients with the syndrome. (endocrineweb.com)
  • Lean controls (mean glucose infusion rate 339 ± 76 mg/min/m 2 ) were less insulin resistant than lean patients with polycystic ovary syndrome (270 ± 66 mg/min/m 2 ), overweight controls (264 ± 66 mg/min/m 2 ), and overweight patients with the syndrome (175 ± 9 mg/min/m 2 ). (endocrineweb.com)
  • The investigators concluded that insulin resistance is exacerbated by increased body mass index, supporting intrinsic insulin resistance in polycystic ovary syndrome. (endocrineweb.com)
  • The present randomised, placebo-controlled study was designed to compare the antihyperglycemic drug metformin vs. placebo combined with lifestyle modification in the treatment of polycystic ovary syndrome in obese women. (hu-berlin.de)
  • The observational, case-controlled study was conducted from April 2011 to January 2014 and recruited 192 polycystic ovary syndrome patients and 205 normal women. (ijpsonline.com)
  • About 16% of polycystic ovary syndrome women were obese and 91% reported to have an increased waist/hip ratio. (ijpsonline.com)
  • Oligomenorrhea was observed in 74% women with polycystic ovary syndrome. (ijpsonline.com)
  • 3 One of the commonest presenting complaints of women with polycystic ovary syndrome is anovulatory infertility. (bmj.com)
  • 5 Polycystic ovary syndrome is therefore an important health concern and may represent a major health issue affecting young women today. (bmj.com)
  • The use of metformin for women with polycystic ovary syndrome has aroused a tremendous amount of interest. (bmj.com)
  • Clinical manifestations vary widely among women with this disorder. (springer.com)
  • The purpose of this study is to evaluate the effect of oral contraceptive on the serum free prostatic specific antigen (PSA)in women with polycystic ovary syndrome(PCOD)compared with cyproterone compound. (clinicaltrials.gov)
  • 7 , 8 Polycystic ovaries alone were found in 20%-25% of women in surveys in the United Kingdom and New Zealand. (mja.com.au)
  • Polycystic ovary syndrome is a condition present in approximately 5 to 10 percent of women of childbearing age. (aafp.org)
  • 25 kg/m2) women with the syndrome, and 13 obese and overweight controls (ovulatory women without clinical or biochemical hyperandrogenemia) were selected. (unboundmedicine.com)
  • We measured steroids in serum and performed oral glucose-tolerance tests before and after the oral administration of 1200 mg of D-chiro-inositol or placebo once daily for six to eight weeks in 44 obese women with the polycystic ovary syndrome. (unboundmedicine.com)
  • Cook, C.L., Siow, Y., Brenner, A.G. and Fallat, M.E. (2002) Relationship between serum mullerian-inhibiting substance and other reproductive hormones in untreated women with polycystic ovary syndrome and normal women. (scirp.org)
  • Publication date: Available online 15 February 2019Source: Best Practice &Research Clinical Obstetrics &GynaecologyAuthor(s): Theodoros D. Theodoridis, Panagiotis Pappas, Grigoris F. GrimbizisAbstractThe prevalence of congenital uterine anomalies (CUA) is reported to be 4.3-6.7% in the general population, 3.4%-8% in the infertile population, and 12.6-18.2% of those with recurrent miscarriages. (medworm.com)
  • from the malignant ascites of a patient with progressive adenocarcinoma of the ovary. (atcc.org)
  • Polycystic ovary syndrome causes more than 75% of cases of anovulatory infertility. (wikipedia.org)
  • See 'Treatment of polycystic ovary syndrome in adolescents' . (uptodate.com)
  • High-intensity focused ultrasound for potential treatment of polycystic ovary syndrome: toward a noninvasive surgery. (fusfoundation.org)
  • There also appears to be a defect in the hypothalamic-pituitary-adrenal (HPA) axis in patients presenting with polycystic ovary syndrome. (oawhealth.com)
  • Successful treatment of a stage IIIC small-cell carcinoma of the ovary hypercalcemic subtype using multi-modality therapeutic approach. (ecancer.org)
  • Objective Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is an aggressive tumor, with long term survival at ~ 30% in early stage disease. (elsevier.com)
  • Long Term Sequelae of Polycystic Ovary Syndrome: Diabetes and Cardiovascular Disease 9. (routledge.com)
  • Patients with early-stage disease have a favorable clinical outcome but the prognosis of patients with advanced-stage or recurrent disease is poor. (bmj.com)
  • This disease is related to the number of follicles per ovary each month growing from the average range of 6 to 8 to double, triple or more. (wikipedia.org)
  • In this book, Chapter One reviews the aetiology and pathogenesis of the Polycystic Ovary Syndrome, with the objective to set the ground for future research that could help elucidate which patients have risk of developing the disorder and what triggers this risk, so strategies to prevent it could be found. (novapublishers.com)
  • Comparative treatment between sitagliptin vs. metformin, alone or in combination, in patients with polycystic ovary syndrome. (elsevier.es)
  • Clinical features of patients with polycystic ovary syndrome. (elsevier.es)
  • Oral Quercetin Supplementation Enhances Adiponectin Receptor Transcript Expression in Polycystic Ovary Syndrome Patients: A Randomized Placebo-Controlled Double-Blind Clinical Trial. (wellnessresources.com)
  • Wedlake L.J., McGough C., Shaw C., Klopper T., Thomas K., Lalji A., Dearnaley D.P., Blake P., Tait D., Khoo V.S. & Andreyev H.J.N. (2012) Clinical trial: efficacy of a low or modified fat diet for the prevention of gastrointestinal toxicity in patients receiving radiotherapy treatment for pelvic malignancies. (wiley.com)
  • There were significant correlation between polycystic ovary syndrome of the patients and the mullerian anomalies lesions ( i.e. septate and arcuate uterus) which were seen in them. (scirp.org)
  • Speroff, L. and Fritz, M.A. (2011) Clinical gynecologic endocrinology and infertility. (scirp.org)
  • Journal of Clinical Endocrinology & Metabolism, 92, 240-245. (scirp.org)
  • Journal of Clinical Endocrinology & Metabolism, 91, 941-945. (scirp.org)
  • Polycystic ovary syndrome is a disorder involving infrequent, irregular or prolonged menstrual periods, and often excess male hormone (androgen) levels. (mayoclinic.org)
  • The ovaries also secrete hormones that play a role in the menstrual cycle and fertility . (wikipedia.org)
  • An ultrasound examination of the ovaries is performed to evaluate their size and shape. (encyclopedia.com)
  • Defining the Polycystic Ovary Syndrome 3. (routledge.com)
  • The Pathophysiology of Polycystic Ovary Syndrome 5. (routledge.com)
  • Body Image and Quality of Life with Polycystic Ovary Syndrome 7. (routledge.com)
  • Long Term Sequelae of Polycystic Ovary Syndrome: Gynaecological Cancer 10. (routledge.com)
  • See 'Diagnostic evaluation of polycystic ovary syndrome in adolescents' . (uptodate.com)
  • Zawadzki J, Dunaif A. Diagnostic criteria for polycystic ovary syndrome: Towards a rational approach. (uptodate.com)
  • Evidence-based methodology workshop on polycystic ovary syndrome, 2012. (uptodate.com)
  • However, the disparity of results in clinical studies cannot give us a conclusive answer if metformin is a new line therapy of the syndrome. (hu-berlin.de)
  • This article reports results from a multicenter pragmatic study, with explanatory components and also with a repository, the Pregnancy in Polycystic Ovary Syndrome I study (Clinicaltrials.gov: NCT00068861), which we label with the acronym PERCT. (elsevier.com)
  • Legro, R 2015, ' Pregnancy in Polycystic Ovary Syndrome I: Lessons from a pragmatic explanatory with repository clinical trial ', Seminars in reproductive medicine , vol. 33, no. 3, pp. 213-219. (elsevier.com)
  • Objective To assess the effectiveness of metformin in improving clinical and biochemical features of polycystic ovary syndrome. (bmj.com)
  • Secondary outcomes of clinical and biochemical features of polycystic ovary syndrome. (bmj.com)
  • Polycystic ovary syndrome: clinical perspectives and managemen. (mysciencework.com)
  • Polycystic ovary syndrome: clinical perspectives and management. (mysciencework.com)
  • Randomized controlled trial of letrozole, berberine, or a combination for infertility in the polycystic ovary syndrome. (nih.gov)
  • Cite this: Research in Polycystic Ovary Syndrome Today and Tomorrow - Medscape - Apr 01, 2011. (medscape.com)
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  • Polycystic ovary syndrome was defined as the diagnostic criteria of 2003 census Rotterdam. (clinicaltrials.gov)
  • Major factors contributing to the growth of the global polycystic ovary syndrome market include sedentary lifestyle and faulty dietary habits and increasing female obese population across the globe. (researchandmarkets.com)
  • See related handout on polycystic ovary syndrome , written by the author of this article. (aafp.org)
  • Few agents have been approved by the U.S. Food and Drug Administration specifically for use in polycystic ovary syndrome, and several agents are contraindicated in pregnancy. (aafp.org)
  • Pigny, P., Jonard, S., Robert, Y. and Dewailley, D. (2006) Serum anti-mullerian hormone as a surrogate for antral follicle count for definition of the polycystic ovary syndrome. (scirp.org)
  • Helena J. Teede, MD, Director Monash Centre for Health Research and Implementation, Melbourne, Victoria, Australia, made a case for renaming polycystic ovary syndrome at the 76th Scientific Sessions of the American Diabetes Association, June 10-14, in New Orleans. (endocrineweb.com)
  • Dr. Teede detailed the Rotterdam and National Institutes of Health (NIH) diagnostic criteria for polycystic ovary syndrome. (endocrineweb.com)
  • In the present case report we describe a 67 years old woman with clinically apparent ascites and no systemic causes for it and a giant mucinous cystadenoma of the right ovary diagnosed utilizing the CT scan and confirmed by the histological findings. (clinmedjournals.org)
  • A giant intraperitoneal cystic mass measuring 28.5 × 17.8 × 46.2 cm (with a calculated volume of about 12 liters) was visualized originating from the right ovary with numerous septa displacing the colon, the stomach and pushing up the liver and the spleen with no compression of other abdominal organs (Figure 1). (clinmedjournals.org)
  • CT scan of the abdomen showing a multiseptated mass originating from the right ovary and occupying the whole abdomen. (clinmedjournals.org)
  • The female reproductive organs include the uterus, fallopian tubes, and the ovaries (Fig. 1). (glowm.com)
  • Pathways of Metastases from Primary Organs to the Ovaries," Obstetrics and Gynecology International , vol. 2011, Article ID 612817, 6 pages, 2011. (hindawi.com)
  • Clinical Obstetrics and Gynecology. (lww.com)
  • Special Tumors of Ovary and Testis. (bmj.com)
  • Granulosa cell tumors of the ovary cause higher than normal levels of estrogen in a woman's body. (malacards.org)
  • To characterize clear cell carcinomas in early FIGO stages (I-II) with regard to clinical and biological properties, a retrospective study was performed to compare these tumors with other histological subtypes. (spandidos-publications.com)
  • Clinical manifestations of ascites range from complete absence of symptoms to severely distended abdomen with respiratory distress, pyrosis, abdominal pain, nausea, anorexia. (clinmedjournals.org)
  • Many of these clinical manifestations occur in puberty and have a long-term impact on an adolescent's or woman's daily wellbeing and activities of daily living. (advanceweb.com)
  • In the ovaries, the developing egg cells (or oocytes ) mature in the fluid-filled follicles . (wikipedia.org)
  • The ovaries develop numerous small collections of fluid - called follicles - and may fail to regularly release eggs. (mayoclinic.org)
  • Your ovaries might be enlarged and contain follicles that surround the eggs. (mayoclinic.org)
  • Polycystic Ovaries: Ovaries might get enlarged and comprise follicles surrounding the eggs. (wikipedia.org)