Elements of limited time intervals, contributing to particular results or situations.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
The action of a drug that may affect the activity, metabolism, or toxicity of another drug.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
The rate dynamics in chemical or physical systems.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Established cell cultures that have the potential to propagate indefinitely.
The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.
Therapy with two or more separate preparations given for a combined effect.
The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
A cell line derived from cultured tumor cells.
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
Conversion of an inactive form of an enzyme to one possessing metabolic activity. It includes 1, activation by ions (activators); 2, activation by cofactors (coenzymes); and 3, conversion of an enzyme precursor (proenzyme or zymogen) to an active enzyme.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
Proteins prepared by recombinant DNA technology.
A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).
A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.
The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
The giving of drugs, chemicals, or other substances by mouth.
The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Transport proteins that carry specific substances in the blood or across cell membranes.
Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.
Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.
Antibodies produced by a single clone of cells.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.
Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.
The movement of materials (including biochemical substances and drugs) through a biological system at the cellular level. The transport can be across cell membranes and epithelial layers. It also can occur within intracellular compartments and extracellular compartments.
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.
Administration of the total dose of radiation (RADIATION DOSAGE) in parts, at timed intervals.
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564)
Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.
The action of a drug in promoting or enhancing the effectiveness of another drug.
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.
DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.
Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.
The presence of co-existing or additional diseases with reference to an initial diagnosis or with reference to the index condition that is the subject of study. Comorbidity may affect the ability of affected individuals to function and also their survival; it may be used as a prognostic indicator for length of hospital stay, cost factors, and outcome or survival.
Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.
Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
The parts of a macromolecule that directly participate in its specific combination with another molecule.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
A group of enzymes that catalyzes the phosphorylation of serine or threonine residues in proteins, with ATP or other nucleotides as phosphate donors.
An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.
A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
A subtype of striated muscle, attached by TENDONS to the SKELETON. Skeletal muscles are innervated and their movement can be consciously controlled. They are also called voluntary muscles.
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
Immunologic method used for detecting or quantifying immunoreactive substances. The substance is identified by first immobilizing it by blotting onto a membrane and then tagging it with labeled antibodies.
An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026)
Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.
Single preparations containing two or more active agents, for the purpose of their concurrent administration as a fixed dose mixture.
The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.
Surgical insertion of synthetic material to repair injured or diseased heart valves.
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.
Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity.
A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi).
The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
Treatment that combines chemotherapy with radiotherapy.
Proteins found in any species of bacterium.
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus.
The return of a sign, symptom, or disease after a remission.
Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.
Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.
Disease having a short and relatively severe course.
Structurally related forms of an enzyme. Each isoenzyme has the same mechanism and classification, but differs in its chemical, physical, or immunological characteristics.
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
Semiautonomous, self-reproducing organelles that occur in the cytoplasm of all cells of most, but not all, eukaryotes. Each mitochondrion is surrounded by a double limiting membrane. The inner membrane is highly invaginated, and its projections are called cristae. Mitochondria are the sites of the reactions of oxidative phosphorylation, which result in the formation of ATP. They contain distinctive RIBOSOMES, transfer RNAs (RNA, TRANSFER); AMINO ACYL T RNA SYNTHETASES; and elongation and termination factors. Mitochondria depend upon genes within the nucleus of the cells in which they reside for many essential messenger RNAs (RNA, MESSENGER). Mitochondria are believed to have arisen from aerobic bacteria that established a symbiotic relationship with primitive protoeukaryotes. (King & Stansfield, A Dictionary of Genetics, 4th ed)
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
The part of a cell that contains the CYTOSOL and small structures excluding the CELL NUCLEUS; MITOCHONDRIA; and large VACUOLES. (Glick, Glossary of Biochemistry and Molecular Biology, 1990)
Substances that reduce the growth or reproduction of BACTERIA.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in enzyme synthesis.
The long-term (minutes to hours) administration of a fluid into the vein through venipuncture, either by letting the fluid flow by gravity or by pumping it.
Drugs used to prevent SEIZURES or reduce their severity.
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)
The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)
Pathological conditions involving any of the various HEART VALVES and the associated structures (PAPILLARY MUSCLES and CHORDAE TENDINEAE).
The sum of the weight of all the atoms in a molecule.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
The total amount of radiation absorbed by tissues as a result of radiotherapy.
Compounds with a six membered aromatic ring containing NITROGEN. The saturated version is PIPERIDINES.
Refers to animals in the period of time just after birth.
A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.
A group of compounds that contain the structure SO2NH2.
A statistical means of summarizing information from a series of measurements on one individual. It is frequently used in clinical pharmacology where the AUC from serum levels can be interpreted as the total uptake of whatever has been administered. As a plot of the concentration of a drug against time, after a single dose of medicine, producing a standard shape curve, it is a means of comparing the bioavailability of the same drug made by different companies. (From Winslade, Dictionary of Clinical Research, 1992)
Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER.
Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.
Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.
Tumors or cancer of the LUNG.
The valve between the left ventricle and the ascending aorta which prevents backflow into the left ventricle.
Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Interruption or suppression of the expression of a gene at transcriptional or translational levels.
Multiple physical insults or injuries occurring simultaneously.
Abnormal cardiac rhythm that is characterized by rapid, uncoordinated firing of electrical impulses in the upper chambers of the heart (HEART ATRIA). In such case, blood cannot be effectively pumped into the lower chambers of the heart (HEART VENTRICLES). It is caused by abnormal impulse generation.
Studies comparing two or more treatments or interventions in which the subjects or patients, upon completion of the course of one treatment, are switched to another. In the case of two treatments, A and B, half the subjects are randomly allocated to receive these in the order A, B and half to receive them in the order B, A. A criticism of this design is that effects of the first treatment may carry over into the period when the second is given. (Last, A Dictionary of Epidemiology, 2d ed)
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.
Microscopy of specimens stained with fluorescent dye (usually fluorescein isothiocyanate) or of naturally fluorescent materials, which emit light when exposed to ultraviolet or blue light. Immunofluorescence microscopy utilizes antibodies that are labeled with fluorescent dye.
Adherence of cells to surfaces or to other cells.
A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.
Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
A gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX. DNA METHYLATION may also be triggered during this process.
A protein-serine-threonine kinase that is activated by PHOSPHORYLATION in response to GROWTH FACTORS or INSULIN. It plays a major role in cell metabolism, growth, and survival as a core component of SIGNAL TRANSDUCTION. Three isoforms have been described in mammalian cells.
The use of IONIZING RADIATION to treat malignant NEOPLASMS and some benign conditions.
Filamentous proteins that are the main constituent of the thin filaments of muscle fibers. The filaments (known also as filamentous or F-actin) can be dissociated into their globular subunits; each subunit is composed of a single polypeptide 375 amino acids long. This is known as globular or G-actin. In conjunction with MYOSINS, actin is responsible for the contraction and relaxation of muscle.
The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for VIRUS CULTIVATION and antitumor drug screening assays.
Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.
Intracellular fluid from the cytoplasm after removal of ORGANELLES and other insoluble cytoplasmic components.
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN.
The process of moving proteins from one cellular compartment (including extracellular) to another by various sorting and transport mechanisms such as gated transport, protein translocation, and vesicular transport.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism.
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
A light microscopic technique in which only a small spot is illuminated and observed at a time. An image is constructed through point-by-point scanning of the field in this manner. Light sources may be conventional or laser, and fluorescence or transmitted observations are possible.
Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.
Injections made into a vein for therapeutic or experimental purposes.
Surgical therapy of ischemic coronary artery disease achieved by grafting a section of saphenous vein, internal mammary artery, or other substitute between the aorta and the obstructed coronary artery distal to the obstructive lesion.
The biosynthesis of PEPTIDES and PROTEINS on RIBOSOMES, directed by MESSENGER RNA, via TRANSFER RNA that is charged with standard proteinogenic AMINO ACIDS.
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
A genetic rearrangement through loss of segments of DNA or RNA, bringing sequences which are normally separated into close proximity. This deletion may be detected using cytogenetic techniques and can also be inferred from the phenotype, indicating a deletion at one specific locus.
The number of times the HEART VENTRICLES contract per unit of time, usually per minute.
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
The process of cleaving a chemical compound by the addition of a molecule of water.
Molecules or ions formed by the incomplete one-electron reduction of oxygen. These reactive oxygen intermediates include SINGLET OXYGEN; SUPEROXIDES; PEROXIDES; HYDROXYL RADICAL; and HYPOCHLOROUS ACID. They contribute to the microbicidal activity of PHAGOCYTES, regulation of signal transduction and gene expression, and the oxidative damage to NUCLEIC ACIDS; PROTEINS; and LIPIDS.
Any of various enzymatically catalyzed post-translational modifications of PEPTIDES or PROTEINS in the cell of origin. These modifications include carboxylation; HYDROXYLATION; ACETYLATION; PHOSPHORYLATION; METHYLATION; GLYCOSYLATION; ubiquitination; oxidation; proteolysis; and crosslinking and result in changes in molecular weight and electrophoretic motility.
Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.
Glycoproteins found on the membrane or surface of cells.
Experimental transplantation of neoplasms in laboratory animals for research purposes.
The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.
... and clinical characteristics". Clinical Therapy. 29 (8): 1548-58. doi:10.1016/j.clinthera.2007.08.008. PMID 17919538. Carini, F ... Concomitant treatment should be avoided. The additional beneficial effect of HRT (hormone replacement therapy) with estrogens/ ... No clinical consequences are known. The combination of NSAIDs and alendronate may increase the risk of gastric ulcers. Both ... of age, as no clinical data exists for this population Gastrointestinal tract: Ulceration and possible rupture of the esophagus ...
A controlled clinical study in patients with aortic ball valves". American Heart Journal. 94 (1): 101-11. doi:10.1016/S0002- ... Stormorken, H; Bjørnerud, B; Chye, NE (1 October 1982). "A new constellation: females with concomitant von Willebrand's disease ... He described the multifaceted Stormorken syndrome, a mutations in f. VII, f. IX, Fibrinogen Oslo IV and V, all with clinical ... Pande, Helens; Chester, Alan; Lia, Halldis; Tharsby, Erik; Stormorken, Helge (28 June 2008). "Concomitant occurrence of ...
Electroencephalography and Clinical Neurophysiology, 9, 673-690. Morrison, A R (1983). A window on the sleeping brain. ... ISBN 1-899398-36-8 Aserinsky, . and Kleitman, N (1953). Regularly occurring periods of eye mobility and concomitant phenomena ...
"The Journal of Clinical Investigation. 112 (7): 973-7. doi:10.1172/JCI19993. PMC 198535. PMID 14523031.. ... "Information for Healthcare Professionals: Concomitant Use of Ibuprofen and Aspirin". FDA. U.S. Department of Health & Human ... "Journal of Clinical Pharmacology. 13 (11): 480-6. doi:10.1002/j.1552-4604.1973.tb00203.x. PMID 4490672. Archived from the ... Marx J (2006). Rosen's emergency medicine: concepts and clinical practice. Mosby/Elsevier. p. 2242. ISBN 978-0-323-02845-5.. ...
Roger C, Roberts JA, Muller L (May 2018). "Clinical Pharmacokinetics and Pharmacodynamics of Oxazolidinones". Clinical ... Huang V, Gortney JS (December 2006). "Risk of serotonin syndrome with concomitant administration of linezolid and serotonin ... Stalker DJ, Jungbluth GL (2003). "Clinical pharmacokinetics of linezolid, a novel oxazolidinone antibacterial". Clinical ... Clinical guidelines for the treatment of community-acquired pneumonia developed by the American Thoracic Society and the ...
Specific deficiency of eosinophil peroxidase without concomitant deficiency of myeloperoxidase is rare. In a clinical setting, ... Clinical Applications. 3 (10): 1151-1173. doi:10.1002/prca.200900043. PMC 2967046. PMID 21048890. Zederbauer M, Furtmüller PG, ... Lanza F (September 1998). "Clinical manifestation of myeloperoxidase deficiency". Journal of Molecular Medicine. 76 (10): 676- ...
"Clinical Features of Patients with Concomitant Parkinson's Disease and Progressive Supranuclear Palsy Pathology". Movement ... a clinical report on eight cases of "heterogenous system degeneration"". Transactions of the American Neurological Association ... Moore DP, Puri BK (2012-06-29). Textbook of Clinical Neuropsychiatry and Behavioral Neuroscience. pp. 400-401. ISBN 978-1-4441- ... A clinical diagnosis of normal pressure hydrocephalus was entertained. Imaging did not support this, however, and on formal ...
Its clinical use may grow to include this indication. Colchicine is also being studied in clinical trials for possible effects ... Colchicine toxicity can be potentiated by the concomitant use of cholesterol-lowering drugs. Deaths - both accidental and ... Cerquaglia C, Diaco M, Nucera G, La Regina M, Montalto M, Manna R (February 2005). "Pharmacological and clinical basis of ... Qaseem A, Harris RP, Forciea MA (January 2017). "Management of Acute and Recurrent Gout: A Clinical Practice Guideline From the ...
Schiebinger L (October 2003). "Women's health and clinical trials". The Journal of Clinical Investigation. 112 (7): 973-7. doi: ... ISBN 978-0-9626523-8-7. "Information for Healthcare Professionals: Concomitant Use of Ibuprofen and Aspirin". FDA. U.S. ... No clinical signs of toxicosis occurred when cats were given 25 mg/kg of aspirin every 48 hours for 4 weeks, but the ... Naproxen has been shown to be as effective as aspirin and less toxic, but due to the limited clinical experience, naproxen is ...
Colina KF, Abelson HT (March 1995). "Resolution of breath-holding spells with treatment of concomitant anemia". J. Pediatr. 126 ... Donma MM (January 1998). "Clinical efficacy of piracetam in treatment of breath-holding spells". Pediatr. Neurol. 18 (1): 41-5 ...
Ordóñez Gallego A, González Barón M, Espinosa Arranz E (May 2007). "Oxycodone: a pharmacological and clinical review". Clinical ... "Oxycodone concentrations are greatly increased by the concomitant use of ritonavir or lopinavir/ritonavir". European Journal of ... The first clinical use of the drug was documented in 1917, the year after it was first developed. It was first introduced to ... Ntranos A, Shoirah H, Dhamoon MS, Hahn D, Naidich TP, Shin S (March 2017). "Clinical Reasoning: A young woman with respiratory ...
Concomitant therapy of ritonavir with a variety of medications may result in serious and sometimes fatal drug interactions. The ... European Journal of Clinical Pharmacology. 66 (10): 977-985. doi:10.1007/s00228-010-0879-1. ISSN 0031-6970. PMID 20697700. ... "Oxycodone concentrations are greatly increased by the concomitant use of ritonavir or lopinavir/ritonavir". ...
Attenuation of Kernig's sign by concomitant hemiparesis: forgotten aspects of a well known clinical test. Journal of Neurology ...
Concomitant with this new clinical care focus, strength in applied neuroscience research began to emerge. In 1980, the Playfair ... A Clinical Report on Eight Cases of 'heterogenous System Degeneration'". Transactions of the American Neurological Association ... Within this location, the Krembil occupies 105,000 sq ft (9,800 m2) dedicated to a full range of basic science, clinical, ... Rutka, J. T.; Wallace, C (2010). "Excellence in neurosurgery program building: Enhancing the academic mission". Clinical ...
A trauma-focused clinical approach should be implemented; tibial, knee, femur, hip, and head injuries should be ruled out by ... Since calcaneal fractures are related to falls from height, other concomitant injuries should be evaluated. Vertebral ... Clinical Orthopaedics and Related Research (207): 122-5. doi:10.1097/00003086-198606000-00022. PMID 3720074. Berry, G. K.; ... Evaluating soft-tissue involvement is the most important aspect of the clinical examination because of its association with ...
Basic and Clinical Pharmacology. McGraw-Hill. 1998: 584.. *^ Loh HS, Watters K & Wilson CW. The Effects of Aspirin on the ... Information for Healthcare Professionals: Concomitant Use of Ibuprofen and Aspirin. FDA. United States Department of Health and ... BMJ (Clinical research ed.). 2008-01-12, 336 (7635): 88-92. PMC 2190284. PMID 18187725. doi:10.1136/bmj.39412.705868.AD.. ... BMJ (Clinical research ed.). 2000, 321 (7276): 1591-1594. PMC 1119266. PMID 11124191. doi:10.1136/bmj.321.7276.1591.. ...
No clinical experience exists in patients under 18 years of age. The drug should therefore not be used in pediatric patients. ... The concomitant use of low-potency topical corticosteroids was permitted during the treatment phase with alefacept and does not ... Infections : In clinical studies 0.9% of patients experienced significant infections compared to 0.2% in the placebo group. ... Lymphopenia : Most common in clinical trials was a significant and dose-related reduction of CD4+ and CD8+ counts in 10 to 59% ...
However, the onset of action varies significantly and clinical efficacy is not always directly related to only the H1 receptor ... "Evaluation of the pharmacokinetics and electrocardiographic pharmacodynamics of loratadine with concomitant administration of ... Review of its effects on cognition, psychomotor performance, mood and sedation". Clinical and Experimental Allergy. 29 Suppl 3 ... Devillier P, Roche N, Faisy C (2008). "Clinical pharmacokinetics and pharmacodynamics of desloratadine, fexofenadine and ...
In placebo-controlled clinical trials of up to nine weeks' duration of patients with MDD, a systematic evaluation of ... Monoamine oxidase inhibitors (MAOIs): concomitant use in patients taking MAOIs is contraindicated. Uncontrolled narrow-angle ... In four clinical trials of duloxetine for the treatment of MDD, sexual dysfunction occurred significantly more frequently in ... As suicidal ideation and behavior in clinical trials are rare, the results for any drug taken separately usually do not reach ...
According to clinical trials, ledipasvir/sofosbuvir has been very well tolerated with the most common side effects being ... Concomitant use will decrease the blood concentration of Harvoni and thus, have reduced therapeutic effects. Ledipasvir ... After completing Phase III clinical trials, on February 10, 2014 Gilead filed for U.S. approval of a ledipasvir/sofosbuvir ...
Clinical trial number NCT01465347 for "Safety and Efficacy Study of Trans Sodium Crocetinate (TSC) With Concomitant Radiation ... National Cancer Institute of Canada Clinical Trials Group) (March 2005). "Radiotherapy plus concomitant and adjuvant ... cancer effects and results from ongoing Phase 3 clinical trials in extra-cranial cancers may help facilitate increased clinical ... A pivotal clinical trial carried out in the early 1970s showed that among 303 GBM patients randomized to radiation or ...
It may exist with or without concomitant decrease in crown-to-root ratio (recession of alveolar bone). Various classifications ... Many cases which are encountered in daily clinical practice cannot be classified according to the criteria of the present ... Journal of Clinical Periodontology. 34 (12): 1046-1061. doi:10.1111/j.1600-051X.2007.01149.x. PMID 17953693. Chrysanthakopoulos ...
"British Journal of Clinical Pharmacology. 50 (6): 581-589. doi:10.1046/j.1365-2125.2000.00290.x. PMC 2015013. PMID 11136297.. ... "Evaluation of the pharmacokinetics and electrocardiographic pharmacodynamics of loratadine with concomitant administration of ... "Clinical and Experimental Allergy. 29 Suppl 3: 147-50. doi:10.1046/j.1365-2222.1999.0290s3147.x. PMID 10444229.. ... However, the onset of action varies significantly and clinical efficacy is not always directly related to only the H1 receptor ...
van Harten J (March 1993). "Clinical pharmacokinetics of selective serotonin reuptake inhibitors". Clinical Pharmacokinetics. ... Because of the potentially hazardous consequences, the concomitant use of tizanidine with fluvoxamine, or other potent ... Fluvoxamine was the first SSRI approved for clinical use in the United Kingdom. It was notably used by Eric Harris, one of the ... 2007) [1994]. Clinical Pharmacy and Therapeutics (4th ed.). Edinburgh: Churchill Livingstone Elsevier. ISBN 978-0-7020-4293-5. ...
The diagnosis is based on clinical features, with a concomitant decreased blood adenosine deaminase level supporting the ... Clinical Immunology. 123 (2): 139-147. doi:10.1016/j.clim.2006.12.009. PMID 17300989. Naam, Ramez (2005-07-03). "'More Than ...
October 2010). "Clinical trial: inhibitory effect of revaprazan on gastric acid secretion in healthy male subjects". Journal of ... Focks JJ, Brouwer MA, van Oijen MG, Lanas A, Bhatt DL, Verheugt FW (April 2013). "Concomitant use of clopidogrel and proton ... January 2021). "Severe clinical outcomes of COVID-19 associated with proton pump inhibitors: a nationwide cohort study with ... In general, the findings of the available studies do not fit with our clinical experience nor is the magnitude of the ...
"Alcoholism: Clinical and Experimental Research. 33 (10): 1815-1825. doi:10.1111/j.1530-0277.2009.01020.x. PMC 2832705. PMID ... "The Synergistic Effect of Concomitant Schistosomiasis, Hookworm, and Trichuris Infections on Children's Anemia Burden". PLoS ... Kwan C.; Ernst J. (2011). "HIV and Tuberculosis: A Deadly Human Syndemic". Clinical Microbiology Reviews. 24 (2): 351-376. doi: ... During a randomized, double-blind clinical trial testing the efficacy of the prototype HIV vaccine called V520 there appeared ...
Given the complexity of hip and groin anatomy and clinical conditions, imaging-guided injections are useful both for the ... Often, patients with hip conditions have concomitant knee or spine conditions, which may present difficult therapeutic and ...
"British Journal of Clinical Pharmacology. 54 (6): 577-82. doi:10.1046/j.1365-2125.2002.01699.x. PMC 1874503. PMID 12492603.. ... "reduce pain and concomitant mood disturbance and increase quality of life."[151] ... clinical statisticians and pharmacologists, use clinical trials to reveal such effects, allowing physicians to offer a ... "British Medical Journal (Clinical Research Ed.). 287 (6388): 307-08. doi:10.1136/bmj.287.6388.307. PMC 1548588. PMID 6307462. ...
Most often, affected individuals display one clear type or another, but sometimes there can be more than one clinical variant ... Oral candidiasis occurs in about two thirds of people with concomitant AIDS and esophageal candidiasis. The incidence of all ... History, classification, and clinical presentation". Oral surgery, oral medicine, and oral pathology. 78 (2): 189-93. doi: ... Lupus.[medical citation needed] The diagnosis can typically be made from the clinical appearance alone, but not always. As ...
Ashraf Mozayani; Lionel Raymon (18 September 2011). Handbook of Drug Interactions: A Clinical and Forensic Guide. Springer ... does not require concomitant treatment with a glucocorticoid.[108] ... Kavoussi P, Costabile RA, Salonia A (17 October 2012). Clinical Urologic Endocrinology: Principles for Men's Health. Springer ... Terrence Priestman (26 May 2012). Cancer Chemotherapy in Clinical Practice. Springer Science & Business Media. pp. 97-. ISBN ...
Jan 1984). "Concomitant bitolterol mesylate aerosol and theophylline for asthma therapy, with 24 hr electrocardiographic ... Adverse Effects and Clinical Efficacy in Asthma". Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy. 5 (3): ...
Schneider, K. (1959). Clinical Psychopathology. New York: Grune and Stratton.. *^ Frith, CD; Blakemore, S; Wolpert, DM (2000 ... while voluntary movements of the same body part included the concomitant activation of motor association cortex associated with ... the premotor process.[181] The clinical definition requires "feeling that one limb is foreign or has a will of its own, ...
Initial X-ray can confirm the diagnosis as well as evaluate for any concomitant fractures. Post-reduction radiographs confirm ... Clinical prediction rules. *Revised Trauma Score. *Injury Severity Score. *Abbreviated Injury Scale ...
Clinical Medicine: Circulatory, Respiratory, and Pulmonary Medicine. 2: 35-44. PMC 2990232. PMID 21157520. Retrieved 14 ... The relationship between chronic stress and its concomitant activation of the HPA axis, and dysfunction of the immune system is ... Molecular Neuropharmacology: A Foundation for Clinical Neuroscience (2nd ed.). New York: McGraw-Hill Medical. pp. 246, 248-259 ...
Such markers are often based on single cases described in clinical literature in the late nineteenth century. One such marker ... such as suppression of the immune system and a possible concomitant decrease in antimicrobial activity in the oral cavity. ...
a b c d LUNGFUNKTION - Practice compendium for semester 6. Department of Medical Sciences, Clinical Physiology, Academic ... in the absence of concomitant changes in the standard markers, discrepancies in mid-range expiratory flow may not be specific ... "Journal of Allergy and Clinical Immunology. 126 (3): 527-534.e8. doi:10.1016/j.jaci.2010.05.016. PMC 2933964 .. ... Clinic, the Cleveland (2010). Current clinical medicine 2010 (2nd ed.). Philadelphia, Pa.: Saunders. p. 8. ISBN 1416066438.. ...
"concomitant strabimus". TheFreeDictionary. Farlex.. *↑ 38.0 38.1 Wright, Kenneth Weston; Spiegel, Peter H. (జనవరి 2003). ... Rosenbaum, Arthur L.; Santiago, Alvina Pauline (1999). Clinical Strabismus Management: Principles and Surgical Techniques. ...
Clinical symptoms typically appear within 30 minutes, but may take up to two hours, depending on other foods and activities.[35 ... "Lactose malabsorption" refers to the physiological concomitant of lactase deficiency (i.e., the body does not have sufficient ... Vandenplas Y (2015). "Lactose intolerance". Asia Pacific Journal of Clinical Nutrition (Review). 24 Suppl 1 (S1): S9-13. doi: ... Lawson M, Bentley D, Lifschitz C (2002). Pediatric gastroenterology and clinical nutrition. London: Remedica. p. 109. ISBN 978- ...
... clinical endpoint - clinical latency - clinical practice guidelines - clinical trial - clinicaltrials.gov - cloning - CMS - CMV ... concomitant drugs - condyloma - condyloma acuminatum - contagious - contraindication - controlled trials - core - core protein ... Community Programs for Clinical Research on AIDS (CPCRA) - community-based clinical trial (CBCT) - community-based organization ... Adult AIDS Clinical Trials Group (AACTG) - adverse drug reaction - aerosolized - AETC - agammaglobulinemia - Agency for ...
Epstein, Murray MD, "Diagnosis and Management of Hypertensive Emergencies," clinical Cornerstone. Hypertension Vol2. No 1. ... in theory it could be beneficial in hypertensive patients with concomitant chronic kidney disease.[citation needed] ... Concomitant use of fenoldopam with a beta-blocker should be avoided if possible, as unexpected hypotension can result from beta ... and a linear dose-response relationship at usual clinical doses.[9] ...
... classification with APS requires one clinical and one laboratory manifestation: *Clinical: *A documented episode of arterial, ... The antiphospholipid syndrome responsible for most of the miscarriages in later trimesters seen in concomitant systemic lupus ... Erkan D, Derksen R, Levy R, Machin S, Ortel T, Pierangeli S, Roubey R, Lockshin M (2011). "Antiphospholipid Syndrome Clinical ... The diagnostic criteria require one clinical event (i.e. thrombosis or pregnancy complication) and two antibody blood tests ...
Academic Clinical Oncology and Radiobiology Research Network: A NCRI initiative to revitalise radiation therapy research (UK) ... This schedule, known as a concomitant boost regimen or hyperfractionation, is used on tumors that regenerate more quickly when ... Thwaites DI, Tuohy JB (July 2006). "Back to the future: the history and development of the clinical linear accelerator". ... Thwaites DI, Tuohy JB (July 2006). "Back to the future: the history and development of the clinical linear accelerator". ...
... a clinical practice guideline". BMJ (Clinical research ed.). 360: k243. PMID 29437651.. ... options for skin and soft tissue abscesses in injecting drug users with consideration of the natural history and concomitant ... Ferri, Fred F. (2014). Ferri's Clinical Advisor 2015 E-Book: 5 Books in 1. Elsevier Health Sciences. p. 20. ISBN 9780323084307. ... Marx, John A. Marx (2014). "Skin and Soft Tissue Infections". Rosen's emergency medicine : concepts and clinical practice (8th ...
Concomitant use of MRAs, including fenfluramine, amphetamine, and pseudoephedrine may cause toxicity via serotonin syndrome or ... Tranylcypromine has been found to inhibit CYP46A1 at nanomolar concentrations.[16] The clinical relevance of this effect is ... Concomitant use of serotonin-enhancing drugs, including SSRIs, serotonergic TCAs, dextromethorphan, and meperidine may cause ... Le Gassicke, J; Ashcroft, GW; Eccleston, D; Evans, JI; Oswald, I; Ritson, EB (1 April 1965). "The Clinical State, Sleep and ...
Clinical decision support system[edit]. Clinical decision support systems are interactive computer programs designed to assist ... potentially concomitant, disease or condition. This may occur as a result of an incidental finding of a sign unrelated to the ... a b c Making a diagnosis, John P. Langlois, Chapter 10 in Fundamentals of clinical practice (2002). Mark B. Mengel, Warren Lee ... Main article: Clinical case definition. The term diagnostic criteria designates the specific combination of signs, symptoms, ...
Clinical significance[edit]. Many diseases are the result of a homeostatic failure. Almost any homeostatic component can ... The concomitant rise in the plasma bicarbonate mops up the increased hydrogen ions (caused by the fall in plasma pH) and the ... "In Mahadevan, S.V.; Garmel, Gus M. An introduction to clinical emergency medicine (2nd ed.). Cambridge: Cambridge University ... Gray's anatomy : the anatomical basis of clinical practice. Standring, Susan, (41st ed.). [Philadelphia]. pp. 141, 151-152. ...
Wang X, Chen C, Wang L, Chen D, Guang W, French J (2003). "Conception, early pregnancy loss, and time to clinical pregnancy: a ... Yip S, Sahota D, Cheung L, Lam P, Haines C, Chung T (2003). "Accuracy of clinical diagnostic methods of threatened abortion". ...
of Clinical Neuroscience, Lund University, Sweden.. *. Compton DG (1993). Stammering : its nature, history, causes and cures. ... and physical concomitants during speech (Riley's Stuttering Severity Instrument Fourth Edition (SSI-4)).[41] They might also ... McCord, Hallack (1955). "Hypnotherapy and stuttering". Journal of Clinical and Experimental Hypnosis. 3 (4): 210-214. doi: ... Stuttering can also diagnosed per the DSM-5 diagnostic codes[44] by clinical psychologists with adequate expertise. The most ...
The clinical presentation among invasive disease is also dominated by skin and soft tissue infections, including a small subset ... Watanabe, Shinya; Shimomura, Yumi; Ubukata, Kimiko; Kirikae, Teruo; Miyoshi-Akiyama, Tohru (2013-11-01). "Concomitant ... The clinical presentation is dominated by severe sepsis and the formation of microabscesses, and a relationship between disease ... The clinical manifestations in human disease range from superficial skin-infections and tonsillitis, to severe necrotising ...
1997). "Growing skull fractures: a clinical study of 41 patients". Acta Neurochir (Wien). 139: 928-32. doi:10.1007/bf01411301. ... with different types of fractures and it is also possible for diastasis of the cranial sutures to occur without a concomitant ... Johannes Lang: Skull base and related structures: atlas of clinical anatomy. P.208. F.K.Schattauer, Germany;(July 1999) ISBN 3- ... Neuroimaging: Clinical and Physical Principles By Robert A. Zimmerman, Wendell A. Gibby, Raymond F. Carmody Publisher: Springer ...
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2015). Essential clinical anesthesia review : keywords, questions and answers for the boards. p. 480. ISBN 9781107681309. . ... Concomitant AF surgery is more likely to lead to the person being free from atrial fibrillation and off medications three ... "BMJ (Clinical Research Ed.). 348: g2116. doi:10.1136/bmj.g2116. PMC 4688652. PMID 24733535.. ... "BMJ (Clinical Research Ed.). 532: h7013. doi:10.1136/bmj.h7013. PMC 5482349. PMID 26786546.. ...
The clinical trial comprised a double-blind, placebo-controlled, crossover trial of 21 healthy adult men with a mild sleep ... "Safety and Efficacy Study of Trans Sodium Crocetinate (TSC) With Concomitant Radiation Therapy and Temozolomide in Newly ... The drug has also been under investigation in a clinical trial sponsored by drug developer Diffusion Pharmaceuticals for ... "Diffusion Pharmaceuticals Announces FDA Accelerated Review of TSC Clinical Development Plan to Treat COVID-19 Patients with ...
Clinical pathological and experimental studies". Surg Gynecol Obstet. 55: 570-80.. *^ Hecker R, Sherlock S (December 1956). " ... The concomitant infusion of albumin can avert the circulatory dysfunction that occurs after large-volume paracentesis and may ... 2005). "MELD score and clinical type predict prognosis in hepatorenal syndrome: relevance to liver transplantation". Hepatology ... Diagram showing hypothesized correlation between clinical features and pathophysiology of ascites and hepatorenal syndrome. ...
In a large clinical trial of the rivastigmine patch in 1,195 patients with Alzheimer's disease, the target dose of 9.5 mg/24- ... "Response to rivastigmine or donepezil in Alzheimer's patients with symptoms suggestive of concomitant Lewy body pathology". ... Jann, M. W.; Shirley, K. L.; Small, G. W. (2002). "Clinical Pharmacokinetics and Pharmacodynamics of Cholinesterase Inhibitors ... hour patch provided similar clinical effects (e.g. memory and thinking, activities of daily living, concentration) as the ...
"Journal of Clinical Psychology. 62: 735-50.. *^ Moos RH, Finney JW, Ouimette PC, Suchinsky RT (March 1999). "A comparative ... and a concomitant of, the compulsion to masturbate while entertaining homosexual and perverse fantasies. The addiction syndrome ... "Motivational incentives research in the National Drug Abuse Treatment Clinical Trials Network". Johns Hopkins University ...
This study correlated assessment tools for evaluating the severity of skin, nail, and joint symptoms in patients with psoriasis (Pso) and psoriatic arthritis (PsA). Adults with plaque Pso (with or without PsA) were enrolled from four U.S. institutions. Patients were evaluated using a novel 10-area Linear Psoriasis Area and Severity Index (XL-PASI), Psoriatic Arthritis Assessment (PsAA), Psoriatic Arthritis Screening and Evaluation Questionnaire (PASE), Nail Assessment (NA) and Joint Assessment (JA) tools, Psoriasis Weighted Extent and Severity Index (PWESI), and Lattice Physician Global Assessment (LS-PGA). Correlations between assessment tools and individual items in the assessment tools were performed. Data from 180 patients (55 with PsA) were analyzed. Highest correlations between tools (r = 0.77-0.88) were between the XL-PASI, PWESI and LS-PGA. Individual items in the XL-PASI correlated with items in the PWESI for extent skin symptoms, but not for all body areas. Overall, correlations were seen
Importance of methotrexate therapy concomitant with tocilizumab treatment in achieving better clinical outcomes for rheumatoid ... and concomitant prednisolone use [OR 0.38 (95% CI 0.21, 0.68)] showed significant predictive values for remission. Concomitant ... Concomitant MTX use is an important component of TCZ treatment for RA patients with high disease activity. ... The purpose of this study was to identify the effects of concomitant use of MTX and baseline characteristics for remission in ...
Phase I/IIa Study of Concomitant Radiotherapy With Olaparib and Temozolomide in Unresectable High Grade Gliomas Patients ... Clinical trial for radiotherapeutic , Radiation Oncology , Glioma , PARP Inhibitor , Radiotherapy , Gliomas , ... Sign up for our FREE service to receive email notifications when clinical trials are posted in the medical category of interest ... Phase I/IIa Study of Concomitant Radiotherapy With Olaparib and Temozolomide in Unresectable High Grade Gliomas Patients ...
Randomized Clinical Trial to Assess the Efficacy and Safety of Concomitant Use of Rifampicin and Efavirenz 600 X 800mg (IPEC- ... In our study we are going to compare the 600 an 800mg doses of efavirenz concomitant of rifampicin use to treat tuberculosis. ... The study consist in a open label randomized clinical trial comparing efavirenz 600mg QID versus efavirenz 800mg QID in ... 600mg X 800mg QID during TB therapy with rifampicin associated with other antituberculosis drugs in patients concomitant ...
Neoadjuvant mFolfirinox With or Without Preoperative Concomitant Chemoradiotherapy in Patients With Borderline Resectable ... Sign up for our FREE service to receive email notifications when clinical trials are posted in the medical category of interest ... Any other severe concomitant disease or disorder, which could influence patients ability to participate in the study and his/ ... Participation in any other clinical trial or treatment with any experimental drug within 28 days before enrolment to the study ...
Prevalence and clinical characteristics of Danon disease among patients with left ventricular hypertrophy and concomitant ... Clinical Trials [13280 Associated Clinical Trials listed on BioPortfolio]. Gene Therapy for Male Patients With Danon Disease ... Prevalence and clinical characteristics of Danon disease among patients with left ventricular hypertrophy and concomitant ... "Prevalence and clinical characteristics of Danon disease among patients with left ventricular hypertrophy and concomitant ...
This is the first study evaluating the role of the RAD51 G172T genetic variants in cancer prognosis and clinical outcome of ... CONCLUSIONS: This is the first study evaluating the role of the RAD51 G172T genetic variants in cancer prognosis and clinical ...
A Phase I Clinical Trial Assessing Temozolamide and Tamoxifen with Concomitant Radiotherapy for the Treatment of High-Grade ... A Phase I Clinical Trial Assessing Temozolamide and Tamoxifen with Concomitant Radiotherapy for the Treatment of High-Grade ... Clinical/Scientific Implications. This is a very interesting study looking at the possibility ofimproving treatment responses ... Pre-clinical data have also shown that protein kinase C (PKC) mediated pathways may play a role in the proliferation of high- ...
1998) Predictors of primary atrial fibrillation and concomitant clinical and hemodynamic changes in patients with chronic heart ... 1998) Predictors of primary atrial fibrillation and concomitant clinical and hemodynamic changes in patients with chronic heart ... The result, in addition to a significant impact on quality of life, is an increase in the risk of a adverse clinical outcomes ... Clinical Heart Failure Patients with Ischemic Stroke Have a High Incidence (>60%) of Atrial Fibrillation or Flutter Whether ...
Clinical Characteristics of Concomitant Primary Biliary Cirrhosis and Graves Disease: A Literature Review Toru Shizuma* ... Clinical & Medical Journals. Anesthesiology Cardiology Clinical Research Dentistry Dermatology Diabetes & Endocrinology ... Citation: Shizuma T (2015) Clinical Characteristics of Concomitant Primary Biliary Cirrhosis and Graves Disease: A Literature ... Characteristics of Patients with Concomitant PBC and GD. The characteristics of the 24 reported patients of concomitant PBC and ...
Concomitant Orbital Tumours: Small Lymphocytic Lymphoma Involving the Lacrimal Gland of a Patient with Clinical Diagnoses of ... Source: Clinical Lymphoma and Myeloma - April 27, 2016. Category: Cancer & Oncology Authors: Kaşifoğlu T, Yaşar Bilge Ş, Yıldız ... Conclusions: CAR T cell therapies have demonstrated the clinical benefits of harnessing our bodys own defenses to combat tumor ... We determined the ratio of patients with malignant disease, characterized the clinical pres... ...
SAT0203 Concomitant Methotrexate Scarcely Augment the Clinical Efficacy of Abatacept in Patients with Rheumatoid Arthritis: A ... SAT0203 Concomitant Methotrexate Scarcely Augment the Clinical Efficacy of Abatacept in Patients with Rheumatoid Arthritis: A ... We have previously reported that concomitant methotrexate (MTX) therapy did not significantly affect the clinical efficacy of ... We suggest that we can expect the adequate clinical efficacy of ABT therapy even in the patients taking no MTX concomitantly. ...
Randomised clinical trial comparing sequential and concomitant therapies for Helicobacter pylori eradication in routine ... Randomised clinical trial comparing sequential and concomitant therapies for Helicobacter pylori eradication in routine ... The results from our study, mimicking routine clinical practice in Spain, suggest that both sequential and concomitant regimens ... Regarding concomitant therapy, another meta-analysis has shown that non-bismuth concomitant regimens containing a PPI, ...
Clinical Trials. *. Abstract B32: RADIANCE: An open-label, nonrandomized, prospective biomarker study to assess analytic ... This was followed by concomitant chemoradiotherapy with concomitant TFHX and twice-daily radiation therapy administered on an ... Concomitant chemoradiotherapy with TFHX has been described previously (21 , 22 , 30 , 31) . Chemotherapy consisted of ... Thus, concomitant treatment addresses the traditional site of failure.. The role of induction chemotherapy is less well defined ...
Rare Cancer News & Clinical Trials » Trial - Sarcoma » A Study of Olaparib With Concomitant Radiotherapy in Locally Advanced/ ... A Study of Olaparib With Concomitant Radiotherapy in Locally Advanced/Unresectable Soft-tissue Sarcoma. ... Interventions: Drug: Olaparib; Radiation: Concomitant Radiotherapy. Sponsors: Institut Bergonié; National Cancer Institute, ...
The concomitant administration of bevacizumab, 5-FU, and cisplatin can improve the clinical effect of the individual drugs and ... Conclusion: The concomitant application of bevacizumab with docetaxel, 5-FU, and cisplatin chemotherapy exhibited good clinical ... Clinical therapeutic effects on patients in the two groups. The effective rates of clinical treatment in the two groups were ... The clinical effect and life quality of patients in the observation and control groups were observed and compared. ...
Clinical Implications. *Concomitant and adjuvant temozolomide chemotherapy added to radiation treatment provides a ... Concomitant temozolomide was given 7 days a week at a dose of 75 mg per square meter body surface area. ... During concomitant temozolomide treatment, grade 3 or 4 neutropenia was demonstrated in 4 percent of patients, and grade 3 or 4 ... Radiotherapy plus Concomitant and Adjuvant Temozolomide for Glioblastoma. Reviewed by: Charles Wood, MD ...
Clinical decisions regarding concomitant use of PPIs and thienopyridines must balance overall risks and benefits, considering ... 8. PPI and Clopidogrel/Prasugrel Clinical Efficacy. 8.1. Do PPIs Decrease Clinical Efficacy of Clopidogrel or Prasugrel?. ... 83 The evidence from these studies and observational comparisons is inconclusive regarding the clinical effects of concomitant ... Advanced age; concomitant use of warfarin, steroids, or NSAIDs; or H. pylori infection all raise the risk of GI bleeding with ...
Concomitant conditions. Careful neurologic examination should be conducted in all patients presenting with signs and symptoms ... Clinical phases. The following 3 clinical phases typically characterize FS:. * Phase 1 - The painful phase; the patient ... Double blind randomized clinical trial examining the efficacy of bupivacaine suprascapular nerve blocks in frozen shoulder. J ... However, the literature offers no consensus regarding the clinical diagnostic criteria for FS. The minimal loss of ROM needed ...
While crenolanib monotherapy has demonstrated clinical benefit in heavily pretreated relapsed/refractory AML patients, ... Concomitant TP53 mutations confer crenolanib resistance. TP53 pathway mutations are mutually exclusive with FLT3 mutations in ... Clinical resistance to crenolanib in acute myeloid leukemia due to diverse molecular mechanisms. *Haijiao Zhang1,2. , ... selective and robust response and are being increasingly used in clinical settings. Strikingly, in the current clinical trial, ...
Concomitant medication use. All concomitant medication use was recorded on the case report form. Analgesics were permitted, and ... Laval Clinical Research Center, Laval, Québec, Canada; Timothy Benstead, MD, Centre for Clinical Research, NS, Canada; Richard ... These clinical trials were only 1-year studies, which may not have been long enough to observe changes in the disease state ... Virtually all clinical trials involving pain-relieving drugs have been short term and solely evaluated changes in the symptoms ...
Use With Concomitant Medications. Anticonvulsants and antiinfectives that induce hepatic enzymes (Table 3) can reduce the ... have been reported in other clinical trials of combination OCs and in the WHO clinical trials of MPA/E2C. 9 ... Based on extensive clinical and introductory trial experience in the US and abroad, the failure rate of MPA/E2C can be ... Multicenter clinical trials conducted by the WHO found that body weight tended to increase among users of MPA/E2C, but that ...
Concomitant Lesions. Of the 141 patients with proven CPFs by echocardiographic studies, 98 (69.5%) had CPFs associated with ... Clinical Features. Table 2⇓ lists the clinical features of patients with pathologically diagnosed CPF in comparison with the ... Clinical Features. The findings of our study were consistent with prior studies with regard to the clinical profile and ... Clinical follow-up data were obtained from clinical visits, mail surveys, or telephone interviews of patients or their families ...
Clinical and genetic analysis of a patient with concomitant 21-hydroxylase deficiency and nephrogenic diabetes insipidus ... Based on the clinical severity, CAH can be classified into classic form of 21OHD (C21OHD) and the mild non-classic form of ... Zou M, Baitei EY, Alzahrani AS, BinHumaid FS, Alkhafaji D, Al-Rijjal RA, Meyer BF, Shi Y. Concomitant RAS, RET/PTC, or BRAF ... YK participated in the clinical diagnosis and treatments. MZ, RA, and BM contributed to the genetic analysis. YK, YS and MZ ...
In line with findings from other countries, Swiss patients with SLE who received belimumab demonstrated clinical and ... This study provides real-world insight into belimumab use in clinical practice in Switzerland. ... Concomitant medications Data on the overall use of corticosteroids were available for 53 patients and data on the ... data on its clinical benefit in everyday clinical practice are scarce. OBSErve (evaluation Of use of Belimumab in clinical ...
The present clinical trial aimed to investigate whether discontinuing MTX for 4 weeks before, during or after seasonal ... Concomitant medications. Adding or changing DMARDs were not allowed until the postvaccination antibody titre was obtained (ie, ... This possibility has important clinical implications. MTX discontinuation will improve responses to vaccines that are based on ... implications for clinical practice. Ann Rheum Dis 2011;70:2144-7.doi:10.1136/ard.2011.152983 ...
Clinical and immunological features of patients with atopy and concomitant HTLV-1 infectio ... Clinical and immunological features of patients with atopy and concomitant HTLV-1 infection. ...
Additionally, the use of concomitant csDMARDs contributed positively to achieve clinical response (OR 7.86; 95% CI 2.39-25.78) ... Clinical response to TNFi was defined as ∆BASDAI ≥ 2 and clinical remission as BASDAI , 2 and CRP ≤ 5 mg/L. Logistic regression ... Seventy-nine patients (44%) received concomitant csDMARDs. The administration of concomitant csDMARDs (OR 3.82; 95% CI 1.06- ... The use of concomitant csDMARDs with TNFi may increase the probability of achieving clinical response in overweight/obese axSpA ...
Clinical Trials - clinicaltrials.gov The b.p.m study will be performed to gain the insight in the courses of illness and ... Clinical Trials [1157 Associated Clinical Trials listed on BioPortfolio]. Fixed Dose Combination of Bisoprolol and Amlodipine ... Clinical Approvals Clinical Trials Drug Approvals Drug Delivery Drug Discovery Generics Drugs Prescription Drugs In the fields ... Home » Topics » The top 5 most promising drugs (February 2014) » Research » Bisoprolol in Hypertension: Effect on Concomitant ...
... and concomitant ultrasound-guided foam sclerotherapy (USGFS) in patients with chronic venous insufficiency. ... Theivacumar NS, Darwood RJ, Dellegrammaticas D et al (2009) The clinical significance of below-knee great saphenous vein reflux ... ELA and concomitant foam sclerotherapy is feasible and effective. The procedures are associated with a low complication rate ... Concomitant USGFS was also technically successful in all cases, but one to three additional sclerotherapy sessions were ...
  • Wedlake L.J., McGough C., Shaw C., Klopper T., Thomas K., Lalji A., Dearnaley D.P., Blake P., Tait D., Khoo V.S. & Andreyev H.J.N. (2012) Clinical trial: efficacy of a low or modified fat diet for the prevention of gastrointestinal toxicity in patients receiving radiotherapy treatment for pelvic malignancies. (wiley.com)
  • Resistance training concomitant to radiotherapy of spinal bone metastases - survival and prognostic factors of a randomized trial. (urotoday.com)
  • Role of the RAD51 G172T polymorphism in the clinical outcome of cervical cancer patients under concomitant chemoradiotherapy. (biomedsearch.com)
  • An improvement in locoregional control appears to be primarily responsible for the positive effects seen in disease-free survival and overall survival when patients receive concomitant chemoradiotherapy. (aacrjournals.org)
  • Impact of GSTM1, GSTT1 and GSTP1 genes polymorphisms on clinical toxicities and response to concomitant chemoradiotherapy in cervical cancer. (cdc.gov)
  • Importance of methotrexate therapy concomitant with tocilizumab treatment in achieving better clinical outcomes for rheumatoid arthritis patients w. (nih.gov)
  • The result, in addition to a significant impact on quality of life, is an increase in the risk of a adverse clinical outcomes including stroke, hospitalization and overall mortality. (scirp.org)
  • Concomitant carcinoma in situ in cystectomy specimens is not associated with clinical outcomes after surgery. (unipd.it)
  • We investigated the outcomes of concomitant therapy (CT) and STT combined with probiotics (STP) as a first-line treatment for H. pylori infection. (elsevier.com)
  • To compare the clinical outcomes of single injection adductor canal block (SACB), continuous adductor canal block (CACB), and the concomitant use of transdermal buprenorphine after total knee arthroplasty (TKA). (bvsalud.org)
  • Gender-related differences in the association between concomitant amplification of AIB1 and HER2 and clinical outcomes in glioma patients. (cdc.gov)
  • He has published more than 700 scholarly articles and edited 3 textbooks on clinical outcomes and research methodology. (springer.com)
  • Conclusions: Bevacizumab concomitant with pemetrexed has better clinical efficacy and safety, giving rise to prolonged survival time in patients with advanced NSCLC. (koreascience.or.kr)
  • Recent clinical studies have evaluated the efficacy electric stimulation for treating OAB [ 13 ] However, a randomized controlled trial (RCT) for validation of the comparative efficacy and safety of acupuncture with electric stimulation as concurrent treatment has not yet been undertaken. (springer.com)
  • Induction chemotherapy with carboplatin and paclitaxel followed by concomitant TFHX (paclitaxel, infusional 5-fluorouracil, hydroxyurea, and twice-daily radiation therapy administered every other week) has resulted in 70% 3-year survival in stage IV patients. (aacrjournals.org)
  • The concomitant application of bevacizumab with docetaxel, 5-FU, and cisplatin chemotherapy exhibited good clinical effect. (alliedacademies.org)
  • We aimed to study the therapeutic effect of the concomitant application of bevacizumab with docetaxel, 5-FU, and cisplatin chemotherapy on patients with advanced gastric cancer. (alliedacademies.org)
  • Concomitant and adjuvant temozolomide chemotherapy added to radiation treatment provides a statistically significant and clinically meaningful survival advantage compared to radiation alone, with a modest increase in treatment toxicity. (oncolink.org)
  • Crenolanib has been evaluated in two phase II clinical trials in chemotherapy or TKI refractory/relapsed AML patients with FLT3 mutations. (nature.com)
  • Temozolomide has demonstrated activity in the treatment of recurrent glioma, and a pilot phase II trial of concomitant temozolomide and radiation therapy followed by adjuvant temozolomide showed promising results. (oncolink.org)
  • The EORTC and NCIC therefore initiated a randomized, multicenter, phase III trial to compare concomitant and adjuvant temozolomide with radiation alone. (oncolink.org)
  • Conclusions: CAR T cell therapies have demonstrated the clinical benefits of harnessing our body's own defenses to combat tumor cells. (medworm.com)
  • Conclusions Unadjusted analysis using greater number of patients compared to our previous study apparently showed the augmenting effect of concomitant MTX usage for the short-term clinical efficacy of ABT. (bmj.com)
  • Conclusions Concomitant therapy led to a non-statistically significant advantage (5%) over sequential therapy, coming closer to 90% cure rates. (bmj.com)
  • Conclusions:BRAF mutants with impaired or unknown kinase activity as well as concomitant kinase-impaired BRAF mutations and RAS mutations were detected in lung cancers, colorectal cancers and melanomas. (elsevier.com)
  • CONCLUSIONS: We could not confirm the prognostic value of concomitant CIS in RC specimens. (unipd.it)
  • In conclusions concomitant Graves' disease and primary hyperparathyroidism is rare, but should be considered in case of persisting hypercalcaemia after the patient became euthyroid again, when parathyroid hormone level is in normal range or elevated. (edu.pl)
  • This is the first study evaluating the role of the RAD51 G172T genetic variants in cancer prognosis and clinical outcome of cervical cancer patients. (biomedsearch.com)
  • The current therapies against cancer such as monoclonal antibodies against checkpoint inhibitors, adoptive T-cell transfer, cytokines, vaccines, and oncolytic viruses have managed to improve the clinical outcome of the patients. (medworm.com)
  • The primary outcome was the overall clinical response, assessed by a physician on a Physician's Global Assessment-like scale, to six months' treatment with belimumab. (smw.ch)
  • Our aim was to evaluate the clinical profile, treatment, and outcome of ceftriaxone-associated postrenal acute renal failure (PARF) in children. (aappublications.org)
  • This study aims to compare the clinical outcome of patients with and without diabetes, presenting with STEMI undergoing primary PCI with concomitant usage of GP IIb/IIIa inhibitors in real clinical practice. (viamedica.pl)
  • In this single centre experience, in diabetic and non-diabetic patients presenting with STEMI, combination therapy with primary PCI and GP IIb/IIIa inhibitors might have contributed to a similar clinical outcome. (viamedica.pl)
  • He is currently an Associate Professor of Cardiology at Sapienza University of Rome, and is an accomplished interventional cardiologist and clinical researcher, with a specific focus on outcome research. (springer.com)
  • Firstly, concomitant IBI in children hospitalized with evidence of recent or intercurrent malaria, with or without severe manifestations, results in a significantly worse outcome. (biomedcentral.com)
  • Concomitant and sequential eradication rates were, respectively, 87% vs 81% by intention-to-treat (p=0.15) and 91% vs 86% (p=0.131) per protocol. (bmj.com)
  • The main objective is to compare the efficacy of optimized triple therapy guided by the results of a PCR test (eradication rates 90% hypothesized) with quadruple concomitant therapy (eradication rate 90% hypothesized). (clinicaltrials.gov)
  • OBJECTIVE: The aim of this study was to externally validate the prognostic value of concomitant urothelial carcinoma in situ (CIS) in radical cystectomy (RC) specimens using a large international cohort of bladder cancer patients. (unipd.it)
  • Pharmacokinetic evaluation of oral levofloxacin in human immunodeficiency virus-infected subjects receiving concomitant antiretroviral therapy. (biomedsearch.com)
  • In this study, we reveal a gender difference in the prognostic value of concomitant AIB1 and HER2 CNG in glioma patients which were barely noticed before. (cdc.gov)
  • Helicobacter pylori eradication is a cost effective measure recommended in most clinical guidelines. (bmj.com)
  • 1998) Predictors of primary atrial fibrillation and concomitant clinical and hemodynamic changes in patients with chronic heart failure A prospective study in 344 patients with baseline sinus rhythm. (scirp.org)
  • The purpose of this study was to identify the effects of concomitant use of MTX and baseline characteristics for remission in the treatment of RA with tocilizumab (TCZ) in daily clinical practice. (nih.gov)
  • Prevalence and clinical characteristics of Danon disease among patients with left ventricular hypertrophy and concomitant electrocardiographic preexcitation. (bioportfolio.com)
  • Clinical characteristics of disease or illness. (bioportfolio.com)
  • The magnitude of the risks may vary among patients, based on their history and clinical characteristics, as may the magnitude of the benefits. (ahajournals.org)
  • The performance characteristics of these tests were influenced negatively by concomitant HIV infection and the presence of other genital ulcer disease pathogens in lesions found to be Treponema pallidum PCR positive. (thefreelibrary.com)
  • Several studies have suggested that concomitant HIV infection may change the performance characteristics of serological tests for syphilis. (thefreelibrary.com)
  • Clinical Characteristics (N = 66). (actasdermo.org)
  • RESEARCH DESIGN AND METHODS A semistructured interview, composed of 14 questions based on the Technology Acceptance Model, was conducted at the end of the clinical trial. (diabetesjournals.org)
  • The study is a prospective, single arm, non-randomized, open label phase II trial, designed to study the safety and efficacy of a medical device, the NovoTTF-100L concomitant with Pemetrexed and cisplatin or carboplatin in Malignant Pleural Mesothelioma patients. (mesothelioma.com)
  • The effect of TTFields has demonstrated significant activity in in vitro mesothelioma pre-clinical models both as a single modality treatment and in combination with pemetrexed and cisplatin, chemotherapies that are commonly used to treat malignant pleural mesothelioma. (mesothelioma.com)
  • Eligible patients will be enrolled, baseline tests will be performed and the patients will be treated continuously with the device concomitant with weekly pemetrexed and cisplatin or carboplatin until disease progression. (mesothelioma.com)
  • The need for retraining and practice is probably related to actual exposure to these interventions in clinical practice. (biomedcentral.com)
  • Concomitant in-hospital clinical practice and other skills retraining should therefore be maintained to ensure adequate proficiency in these interventions. (biomedcentral.com)
  • Confirmation by independent multidisciplinary expert review of borderline resectable status, according to NCCN-Clinical Practice Guidelines in Oncology "pancreatic adenocarcinoma", version 1.2015. (centerwatch.com)
  • Expert consensus documents inform practitioners, payers, and other interested parties of the opinion of ACCF and document cosponsors concerning evolving areas of clinical practice or medical technologies. (ahajournals.org)
  • Expert consensus documents cover topics for which the evidence base, experience with technology, or clinical practice is not considered sufficiently well developed to be evaluated by the formal ACCF/AHA Practice Guidelines process. (ahajournals.org)
  • Thus, the reader should view the expert consensus document as the best attempt of the ACCF and document cosponsors to inform clinical practice in areas where rigorous evidence may not yet be available. (ahajournals.org)
  • This study provides real-world insight into belimumab use in clinical practice in Switzerland. (smw.ch)
  • Clinical endocrinologists worldwide rely on Endocrine Practice, the official journal of the American Association of Clinical Endocrinologists (AACE), to keep them on the leading edge of treatment of patients with endocrine diseases. (aace.com)
  • Do anaesthesiologists in pre-hospital care need concomitant clinical practice? (biomedcentral.com)
  • He uniquely combines expertise in clinical and surgical practice with translational and clinical research skills. (springer.com)
  • With the introduction of artesunate in sub-Saharan Africa (sSA), baseline mortality in children with SM will at best be between 6% to 8.5% but likely to be substantially higher outside the framework of Good Clinical Practice-run trials. (biomedcentral.com)
  • Objectives No trial has compared non-bismuth quadruple 'sequential' and 'concomitant' regimens in settings with increasing clarithromycin rates. (bmj.com)
  • Randomised (1:1) to sequential (omeprazole (20 mg/12 h) and amoxicillin (1 g/12 h) for 5 days, followed by 5 days of omeprazole (20 mg/12 h), clarithromycin (500 mg/12 h) and metronidazole (500 mg/12 h)), or concomitant treatment (same drugs taken concomitantly for 10 days). (bmj.com)
  • Both sequential and concomitant regimens offer similar and acceptable safety profiles and compliance rates. (bmj.com)
  • Recent meta-analysis shows that empiric sequential therapy is less efficacious than concomitant quadruple therapy. (clinicaltrials.gov)
  • Our findings suggest that this novel combination of GM-CSF with sequential and concomitant low-dose cytarabine can benefit patients with poor risk myeloid malignancies. (nature.com)
  • Clinical and immunological features of patients with atopy and concomitant HTLV-1 infection. (bvsalud.org)
  • Conclusively, a new strategy which indicates concomitant eradication in oral and gastric colonization can result in clearance of H. pylori infection. (hindawi.com)
  • The influence of concomitant HIV infection on the serological diagnosis of primary syphilis in southern Africa. (thefreelibrary.com)
  • It aims to increase health professionals' awareness of the clinical features of infectious syphilis, and to consider approaches to the investigation and control of syphilis and other outbreaks of sexually transmitted infection. (bmj.com)
  • The case described here is only the sixth case reported in the literature of concomitant pulmonary tuberculosis and mucormycosis and the third case associated with a TB and mucormycosis co-infection involving an uncontrolled DM patient to survive. (rug.nl)
  • Which children are at greatest risk of developing dual infection and whether this extends across the clinical spectrum (asymptomatic, mild and severe) remains unclear. (biomedcentral.com)
  • Objective: To observe the clinical efficacy of bevacizumab concomitant with pemetrexed in patients with advanced non-small cell lung cancer (NSCLC). (koreascience.or.kr)
  • We have previously reported that concomitant methotrexate (MTX) therapy did not significantly affect the clinical efficacy of ABT [1, 2] using data from our multicenter registry system. (bmj.com)
  • We suggest that we can expect the adequate clinical efficacy of ABT therapy even in the patients taking no MTX concomitantly. (bmj.com)
  • At the completion of therapy the clinical complete response rate rose to 100% with a median follow-up of 29 months. (aacrjournals.org)
  • The variation in prevalence reporting reflects the heterogeneity of the population studied, the criteria used to define symptomatic neuropathy, and the changes in the standard of care or alternatively the degree of DPN symptoms or use of concomitant therapy in that patient population. (diabetesjournals.org)
  • To describe patterns of systemic lupus erythematosus (SLE) care and the clinical effectiveness of belimumab plus standard of care therapy in a real-world clinical setting in Switzerland. (smw.ch)
  • When VIAGRA is co-administered with an alpha-blocker, patients should be stable on alpha-blocker therapy prior to initiating VIAGRA treatment and VIAGRA should be initiated at 25 mg [see WARNINGS AND PRECAUTIONS , DRUG INTERACTIONS , and CLINICAL PHARMACOLOGY ]. (rxlist.com)
  • None of the BETHKIS patients discontinued their therapy due to hearing loss, dizziness or vertigo.Findings related to ototoxicity as measured by audiometric evaluations and auditory adverse event reports were similar between BETHKIS and placebo in controlled clinical trials. (drugs.com)
  • Adverse events are less common with optimized triple therapy than with concomitant quadruple therapy. (clinicaltrials.gov)
  • The secondary objective is to determine side effects of optimized guided triple therapy as well as the quadruple concomitant therapy in France. (clinicaltrials.gov)
  • However, they were subsequently excluded if they had a history of treatment with antibiotics, or had received antiviral therapy during the past 7 days, or failed to give oral informed consent for completion of a questionnaire and collection of clinical specimens. (thefreelibrary.com)
  • In clinical studies, patients have occasionally experienced nausea during calcium acetate therapy. (nih.gov)
  • This analysis of data from clinical trials enrolling patients with pancreatic exocrine insufficiency suggests that the efficacy of pancrelipase/pancreatin is not affected by concomitant PPI/H2RA use, as determined by end-of-treatment CFA values, and supports the treatment guidelines' recommendation that acid suppression is not routinely required with pancreatic enzyme replacement therapy. (nih.gov)
  • To evaluate the clinical efficacy of arthroscopic therapy with infrapatellar fat pad cell concentrates in treating knee cartilage lesions, we conducted a prospective randomized single-blind clinical study of controlled method. (springer.com)
  • In our study, we conducted a randomized controlled trial to evaluate whether knee arthroscopic therapy with IPFP cell concentrates containing MSCs is safe and can improve clinical symptoms of patients with knee cartilage lesions. (springer.com)
  • Addition of AG extract to conventional therapy in diabetes with concomitant hypertension improved arterial stiffness and attenuated systolic BP, thus warrants further investigation on long-term endothelial parameters before recommended as an adjunct treatment. (nih.gov)
  • The study consist in a open label randomized clinical trial comparing efavirenz 600mg QID versus efavirenz 800mg QID in patients with tuberculosis (treated with regimens including rifampicin) and AIDS diagnosis. (clinicaltrials.gov)
  • Aim To determine the incidence of visual impairment (VI) caused by retinopathy of prematurity (ROP) and concomitant disabilities in preterm neonates born between 2000 and 2009 in the Netherlands. (bmj.com)
  • Prevalence and clinical implications of t(11;14) in patients with amyloid light-chain amyloidosis with or without concurrent multiple myeloma. (bioportfolio.com)
  • Results Unadjusted analysis consisted of 217 and 202 patients treated with and without concomitant MTX treatment, respectively. (bmj.com)
  • Multivariate analysis: 'concomitant' treatment showed an OR of 1.5 towards better eradication rate in a borderline significance CI (95% CI 0.9 to 2.8). (bmj.com)
  • Thus, concomitant treatment addresses the traditional site of failure. (aacrjournals.org)
  • In line with findings from other countries, Swiss patients with SLE who received belimumab demonstrated clinical and serological improvements in SLE and a reduction in corticosteroid use after six months of treatment. (smw.ch)
  • King T, Coulomb G, Goldman A et al (2009) Experience with concomitant ultrasound-guided foam sclerotherapy and endovenous laser treatment in chronic venous disorder and its influence on health related quality of life: interim analysis of more than 1000 consecutive procedures. (springer.com)
  • The present clinical trial evaluated the safety and efficacy of UC-II as compared to a combination of glucosamine and chondroitin (G+C) in the treatment of OA of the knee. (medsci.org)
  • Clinical Rheumatology aims to cover all modern trends in clinical and experimental research as well as the management and evaluation of diagnostic and treatment procedures connected with the inflammatory, immunologic, metabolic, genetic and degenerative soft and hard connective tissue diseases. (springer.com)
  • Reserve concomitant prescribing of Butrans and benzodiazepines or other CNS depressants for use in patients for whom alternative treatment options are inadequate. (medicinenet.com)
  • The data include an oral presentation in a Clinical Trials Plenary Session on the Phase III randomized, double-blind, placebo-controlled clinical study of the investigational use of Aliqopa ® (copanlisib) in combination with rituximab given intravenously in patients with relapsed indolent non-Hodgkin's Lymphoma (iNHL) who have relapsed after ≥1 line of treatment, including rituximab (CHRONOS-3). (businesswire.com)
  • In 2017, Aliqopa was approved for the treatment of adult patients with relapsed follicular lymphoma (FL) who have received at least two prior systemic therapies based on the results of a single arm, multi-center, Phase II clinical trial (CHRONOS-1). (businesswire.com)
  • The primary end point for this analysis was on-treatment coefficient of fat absorption (CFA) according to concomitant PPI/H2RA use (yes/no). (nih.gov)
  • TOKYO & DEERFIELD, Ill.--( BUSINESS WIRE )--Otsuka Pharmaceutical Company, Ltd. (Otsuka) and Lundbeck announce that the two companies' third clinical Phase 3 study of brexpiprazole in the treatment of agitation in patients with dementia of the Alzheimer's type will commence in June. (businesswire.com)
  • VIAGRA was shown to potentiate the hypotensive effects of nitrates and its administration in patients who use nitric oxide donors such as organic nitrates or organic nitrites in any form is therefore contraindicated [see CONTRAINDICATIONS , DRUG INTERACTIONS , and CLINICAL PHARMACOLOGY ]. (rxlist.com)
  • The recommended dose for ritonavir-treated patients is 25 mg prior to sexual activity and the recommended maximum dose is 25 mg within a 48 hour period because concomitant administration increased the blood levels of sildenafil by 11-fold [see WARNINGS AND PRECAUTIONS , DRUG INTERACTIONS , and CLINICAL PHARMACOLOGY ]. (rxlist.com)
  • Clinical data have shown that co-administration with saquinavir or erythromycin increased plasma levels of sildenafil by about 3 fold [see DRUG INTERACTIONS and CLINICAL PHARMACOLOGY ]. (rxlist.com)
  • British Journal of Clinical Pharmacology, Vol. 75, Issue. (cambridge.org)
  • Concomitant temozolomide was given 7 days a week at a dose of 75 mg per square meter body surface area. (oncolink.org)
  • Symptoms may or may not develop with the onset of functional abnormalities or mild clinical impairments and are therefore not essential for the diagnosis of DPN. (diabetesjournals.org)
  • Concomitant new diagnosis of systemic lupus erythematosus and COVID-19 with possible antiphospholipid syndrome. (springer.com)
  • To describe the prevalence and clinical features of hidradenitis suppurativa in patients treated at Hospital Italiano de Buenos Aires and determine the frequency of comorbidities and time to diagnosis in this population. (actasdermo.org)
  • Information was extracted from the computerized clinical records of all patients with a diagnosis of hidradenitis suppurativa managed in Hospital Italiano de Buenos Aires between July 2012 and October 2017. (actasdermo.org)
  • This is a multicenter, randomized controlled, parallel clinical trial. (springer.com)
  • In our study we are going to compare the 600 an 800mg doses of efavirenz concomitant of rifampicin use to treat tuberculosis. (clinicaltrials.gov)
  • Based on these published data and on preliminary clinical experience at our own institution, we initiated a single arm study of an out-patient regimen using successive and concurrent GM-CSF with low-dose cytarabine in patients with very poor prognosis AML or MDS. (nature.com)
  • This study aimed to determine whether the efficacy of pancrelipase/pancreatin (CREON®) may be affected by the concomitant use of proton pump inhibitors (PPIs)/histamine-2 receptor antagonists (H2RAs). (nih.gov)
  • Together with the classic Original and Clinical Case Study sections, we also include Reviews, Case Diagnoses, and Book Reviews. (actasdermo.org)
  • The incidence of concomitant disabilities was high and did not differ greatly from the previous study. (bmj.com)
  • The factors, or reasons, that allow a person to participate in a clinical study. (pfizer.com)
  • The factors, or reasons, that prevent a person from participating in a clinical study. (pfizer.com)
  • Therefore, this study evaluates the effect of American ginseng (AG) on arterial stiffness, as measured by augmentation index (AI), and blood pressure (BP), in type 2 diabetes patients with concomitant hypertension. (nih.gov)
  • The clinical significance of non-codon 600 mutations remains unclear, in part, due to variation of kinase activity for different mutants. (elsevier.com)
  • Kinase-impaired BRAF mutants showed a significant association with concomitant activating KRAS or NRAS mutations, but not PIK3CA mutations, supporting the reported interaction of these mutations. (elsevier.com)
  • Different therapeutic strategies based on the BRAF mutant kinase activity and the concomitant mutations may be worthwhile. (elsevier.com)
  • The Prevalence and Clinical Features of Fabry Disease in Hemodialysis Patients: Russian Nationwide Fabry Dialysis Screening Program. (bioportfolio.com)
  • To evaluate the prevalence and clinical features of Fabry disease in patients with end-stage renal disease (ESRD) undergoing chronic hemodialysis. (bioportfolio.com)
  • We present data from the placebo-administered patients from two large, randomized, double-blind, identical, 12-month clinical trials to investigate which factors may impact not only the disease-state progression but also the change in symptoms in patients with mild but clinically symptomatic DPN. (diabetesjournals.org)
  • In this group of patients with spinal bone metastases we were able to show that guided resistance training of the paravertebral muscles had no essential impact on survival concomitant to RT. (urotoday.com)
  • Effect of American ginseng (Panax quinquefolius L.) on arterial stiffness in subjects with type-2 diabetes and concomitant hypertension. (nih.gov)
  • A total of 1027 lung cancer, colorectal cancer or melanoma specimens were submitted for clinical mutation detection by next generation sequencing. (elsevier.com)
  • RESULTS: 1,741 (43.8%) patients had concomitant CIS in their RC specimens. (unipd.it)
  • This, together with the discrepancy between pathologists in determining the presence of concomitant CIS at the morphologic level, limits the clinical utility of concomitant CIS in RC specimens for clinical decision-making. (unipd.it)
  • Concomitant lipid-lowering therapies: use with fibrates or lipid-modifying doses (≥1 g/day) of niacin increases the risk of adverse skeletal muscle effects. (nih.gov)
  • Clinical efficacy, progression-free survival time (PFS), overall survival time (OS), overall response rate (ORR), disease control rate (DCR) and rate of adverse responses between two groups were observed and compared. (koreascience.or.kr)
  • In addition, it reports on the complex and multidisciplinary approach needed to maximize the efficacy, safety, and appropriateness of TAVI, providing detailed clinical, interventional and surgical perspectives focusing on the development of this cardiovascular intervention. (springer.com)
  • Concomitant use of opioids with benzodiazepines or other central nervous system (CNS) depressants, including alcohol , may result in profound sedation, respiratory depression , coma , and death. (medicinenet.com)
  • Furthermore, opioids produce adverse reactions that may obscure the clinical course of patients with head injuries. (fda.gov)
  • Dizziness occurred in two (1.1%) BETHKIS-treated patients and one (0.9%) placebo-treated patient and vertigo occurred in two (1.1%) BETHKIS-treated patients versus no placebo patients in clinical studies. (drugs.com)
  • Clinical efficacy of abatacept in Japanese rheumatoid arthritis patients. (bmj.com)
  • A total of 125 patients who underwent TKA were divided into three groups and the clinical results were retrospecitively compared. (bvsalud.org)
  • Journal of Clinical Tuberculosis and Other Mycobacterial Diseases. (rug.nl)
  • Virtually all clinical trials involving pain-relieving drugs have been short term and solely evaluated changes in the symptoms of DPN without careful assessment of neuropathy parameters. (diabetesjournals.org)
  • Lung adenocarcinoma with concomitant EGFR mutation and ALK rearrangement]. (cepia.team)
  • The decision to initiate a third trial follows discussions with the U.S. Food and Drug Administration (FDA) regarding two Phase 3 clinical trials for the agitation in Alzheimer's disease indication that were completed by Otsuka and Lundbeck in 2017. (businesswire.com)
  • A growing number of small-molecule FLT3 tyrosine kinase inhibitors (TKIs) have been evaluated in preclinical experiments and clinical trials, but only one agent (midostaurin) has been recently approved for this specific use. (nature.com)
  • To investigate the value of endovenous laser ablation (ELA) and concomitant ultrasound-guided foam sclerotherapy (USGFS) in patients with chronic venous insufficiency. (springer.com)
  • However, the analysis with careful adjustment using propensity score matching clearly revealed that the augmenting effect of concomitant MTX on the ABT efficacy was practically limited. (bmj.com)
  • In a pilot clinical trial (first in men) TTFields were shown to have an effect as a monotherapy in one patient with malignant pleural mesothelioma when applied to the patient's abdomen (the disease metastasized to the abdomen). (mesothelioma.com)
  • Substantial pre-clinical and some clinical data are available showing that Asian ginseng (Panax ginseng C.A. Meyer) varieties or its particular ginsenosides exert a vasodilatating effect, thus may modulate vascular function. (nih.gov)