Antioxidant activity of jionoside D from Clerodendron trichotomum. (1/17)
The antioxidant property of jionoside D, isolated from Clerodendron trichotomum (Verbenaceae), was investigated. This compound showed scavenging activity of intracellular reactive oxygen species and of 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, as well as lipid peroxidation inhibitory activity. This radical scavenging activity of jionoside D protected the cell viability of Chinese hamster lung fibroblast (V79-4) cells exposed H2O2. Furthermore, jionoside D reduced the apoptotic cells induced by H2O2, as demonstrated by the decreased number of sub G1 hypo-diploid cells and apoptotic body formation. However, it increased the activities of cellular antioxidant enzymes, superoxide dismutase and catalase. Taken together, these findings suggest that jionoside D, isolated from C. trichotomum, exhibits antioxidant properties. (+info)Evaluation of anticarcinogenic effects of Clerodendron inerme on 7,12-dimethylbenz(a) anthracene-induced hamster buccal pouch carcinogenesis. (2/17)
INTRODUCTION: Oral cancer is the fifth most frequent cancer worldwide and India has recorded the highest incidence (40-50 percent) of oral malignancy. Clerodendron inerme is used by Indian traditional practitioners for the treatment of various ailments, including cancer. Our aim was to investigate the chemopreventive potential of the aqueous leaf extract of Clerodendron inerme (CiAet) in 7,12-dimethylbenz(a) anthracene (DMBA)-induced hamster buccal pouch carcinogenesis. METHODS: We developed oral squamous cell carcinoma in the buccal pouch of male Syrian golden hamsters by painting them with 0.5% DMBA in liquid paraffin thrice a week for 14 weeks. The tumour incidence, tumour volume and tumour burden that were formed in the hamster buccal pouches were determined. RESULTS: Oral administration of CiAet at a dose of 500 mg/kg body weight to DMBA-painted animals on days alternate to DMBA painting for 14 weeks significantly prevented the tumour incidence, tumour volume and tumour burden. CiAet also exerts potent antilipidperoxidative effect and improved the antioxidant defence system in DMBA-painted animals. The chemopreventive efficacy of CiAet was evident by inhibition of tumour formation (80%) in DMBA-painted animals. CONCLUSION: The chemopreventive potential of CiAet is probably due to its antilipidperoxidative effect or the presence of some potent bioactive chemopreventive principles in the leaves of Clerodendron inerme. (+info)Evaluation of the in vivo activity of different concentrations of Clerodendrum umbellatum Poir against Schistosoma mansoni infection in mice. (3/17)
Clerodendrum umbellatum Poir (Verbenaceae) is traditionally used in Cameroon for the treatment of many diseases including intestinal helminthiasis. This study was undertaken to assess the in vivo antischistosomal activity of its leaves aqueous extract on a Schistosoma mansoni mice model and to determine the most effective dose of this extract. Mice showing a patent infection of S. mansoni were daily treated with C. umbellatum leaves aqueous extract at the doses of 40, 80 or 160 mg/kg body weight for 14 days. Seven days after administration of the extract, schistosomicidal activity was evaluated on the liver and spleen weights, faecal eggs releasing, liver egg count and worm burden. Treatment using C. umbellatum leaves aqueous extract resulted in an important reduction in faecal egg output by 75.49% and 85.14% for 80 mg/kg and 160 mg/kg of the extract respectively. These reduction rates did not differ significantly from the 100% obtained in the group of infected mice treated with 100 mg/kg of praziquantel. C. umbellatum leaves aqueous extract was lethal to S. mansoni worm. A 100% reduction rate was recorded in the group of infected mice treated with 160 mg/kg of the extract, as well as in praziquantel-treated mice. An amelioration of the hepatosplenomegaly was noticed in both the extract-treated mice and the praziquantel-treated mice. From these results, we can conclude that C. umbellatum leaves aqueous extract demonstrated schistosomicidal properties in S. mansoni model at doses of at least 80 mg/kg body weight. (+info)Comprehensive review of Clerodendrum phlomidis: a traditionally used bitter. (4/17)
Clerodendrum phlomidis Linn. f., (syn. Clerodendrum multiflorum (Burm.f) O. Kuntze, Volkameria multiflorum Burm. f.) (Lamiaceae) is an important and well known medicinal plant extensively used in Ayurveda and Siddha system of medicine for treatment of various ailments. The popular therapies include on inflammation, diabetes, nervous disorder, asthma, rheumatism, digestive disorders, and urinary disorders as well as a bitter tonic. It was reported that pectolinaringenin, scutellarein, clerodin, clerodendrin, clerosterol, 24beta-ethylcholesta-5,22E,25-triene-3beta-ol, lup-20(29)-en-3-triacontanoate, 4,2',4'-trihydroxy-6'-methoxychalcone-4,4'alpha-D-diglucoside, 7-hydroxyflavone, 7-hydroxyflavanone-7-O-glucoside and alpha-L-rhamnopyranosyl-(1-2)alpha-D-glucopyranosyl-7-O-naringin-4'-O-alpha-D-glu copyranoside-5-methyl ether had been isolated from this plant. The alcoholic and aqueous extracts were reported active as analgesic, antidiarrhoeal, antiplasmodial, hypoglycemic, minor tranquilizers, anti-asthmatic, antifungal, nematicidal, anti-amnestic and anti-arthritic. There are coincidences between some of the traditional usages of this plant and experimentally observed effects of the extracts but very few biological studies available on bioactive fractions and/or pure compounds. This review is an attempt to compile the exhaustive literature on Clerodendrum phlomidis, to highlight, analyze and critically assess the pharmaceutical potential of this underestimated plant in a systematic way. (+info)Antimicrobial and antiparasitic abietane diterpenoids from the roots of Clerodendrum eriophyllum. (5/17)
Chromatographic separation of the roots of a Kenyan medicinal plant, Clerodendrum eriophyllum, led to the isolation of ten abietane diterpenoids (1-10), one of which (1) was isolated for the first time from a natural source. Using spectroscopic data, the structure of 1 was determined to be 12-hydroxy-8,12-abietadiene-3,11,14-trione. Circular dichroism (CD) spectra showed that the stereochemistry of compounds 1, 3, and 6-8 belongs to the normal series of abietane diterpenes, which confirmed the absolute stereochemistry of the isolated compounds. Compounds 1-10 were evaluated for their in vitro antiplasmodial, antileishmanial, antifungal and antibacterial activities. Compounds 3 and 7 exhibited potent antifungal activity (IC50/MIC 0.58/1.25 and 0.96/2.5 microg/mL, respectively) against C. neoformans, whereas 3, 6 and 7 showed strong antibacterial activity against Staphylococcus aureus and methicillin-resistant S. aureus with IC50/MIC values between 1.33-1.75/2.5-5 and 0.96-1.56/2.5 microg/mL, respectively. In addition, compounds 3 and 9 exhibited potent antileishmanial activity (IC50 0.08 and 0.20 microg/mL, respectively) against L. donovani, while 3 and 7 displayed weak antimalarial activity against Plasmodium falciparum, but 9 was inactive. (+info)Development of nuclear SSRs for the insular shrub Clerodendrum izuinsulare (Verbenaceae) and the widespread C. trichotomum. (6/17)
(+info)Isolation, characterization and thin-layer chromatography method development of clerosterol palmityl ester: a chemical marker for standardization of leaves of Clerodendrum phlomidis. (7/17)
OBJECTIVE: Clerosterol palmityl ester (CPE) is a unique clerosterol derivative isolated and characterized from the leaves of Clerodendrum phlomidis. Considering the uniqueness of this compound, the present study was planned to use CPE as a specific chemical marker and develop a new validated thin-layer chromatography (TLC) method for standardisation of C. phlomidis. METHODS: Separation and quantification of CPE were achieved by TLC using a mobile phase of petroleum ether (60 to 80 degrees centigrade) and ethyl acetate (95:5, volume ratio) (Rf 0.64) on precoated silica gel 60F(254) aluminium plates. Densitometric determination was carried out after derivatization with anisaldehyde sulphuric acid reagent in absorption mode at 527 nm. RESULTS: The calibration curve was linear in the concentration range of 100 to 500 ng/spot. The method was validated for precision, repeatability and accuracy. The proposed method was found to be simple, specific, precise, accurate, rapid and cost-effective. CONCLUSION: This TLC procedure may be used effectively for quantitative determination of CPE, identification of the plant and standardization of this plant or its derived products. (+info)Contribution of pollinators to seed production as revealed by differential pollinator exclusion in Clerodendrum trichotomum (Lamiaceae). (8/17)
(+info)Clerodendrum is a genus of flowering plants in the family Lamiaceae, commonly known as the "blue-violet" or "bluebell" family. There are over 400 species of Clerodendrum, which are native to tropical and subtropical regions of the world, including Africa, Asia, and the Americas. In the medical field, some species of Clerodendrum have been used for their medicinal properties. For example, Clerodendrum infortunatum, also known as the "bluebell bush," has been used in traditional medicine to treat a variety of conditions, including fever, headache, and skin infections. The plant contains several compounds that have been shown to have anti-inflammatory, antimicrobial, and antiviral properties. However, it is important to note that the use of Clerodendrum for medicinal purposes should be done under the guidance of a qualified healthcare professional, as some species of the plant can be toxic if ingested or applied topically in large amounts.
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Clerodendrum glabrum
Clerodendrum umbellatum
Clerodendrum tomentosum
Clerodendrum palmatolobatum
Clerodendrum trichotomum
Clerodendrum chinense
Clerodendrum floribundum
Clerodendrum speciosissimum
Clerodendrum quadriloculare
Clerodendrum phlomidis
Clerodendrum cochinchinense
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Lamiaceae2
- Clerodendrum is a genus of flowering plants formerly placed in the family Verbenaceae, but now considered to belong to the Lamiaceae (mint) family. (wikipedia.org)
- This name is the accepted name of a species in the genus Clerodendrum (family Lamiaceae ). (theplantlist.org)
Thomsoniae12
- The following species are cultivated in the UK: C. chinense C. splendens C. thomsoniae C. trichotomum Clerodendrum species are used as food plants by the larvae of some Lepidoptera species including Endoclita malabaricus and Endoclita sericeus. (wikipedia.org)
- Clerodendrum thomsoniae is an evergreen liana growing to 4m (13 feet) tall, native to tropical west Africa from Cameroon west to Senegal. (plantsrescue.com)
- Clerodendrum thomsoniae is a vigorous twining shrub with striking flowers. (plantsrescue.com)
- Grow Clerodendrum thomsoniae in bright filtered light. (plantsrescue.com)
- Clerodendrum thomsoniae plants will do well at normal room temperatures during the active growth period, but they should be given a winter rest in a cool position - ideally at about 10-13C (50-55F). (plantsrescue.com)
- During the active growth period water Clerodendrum thomsoniae plentifully, as much as necessary to keep the potting mixture thoroughly moist, but never allow the pot to stand in water. (plantsrescue.com)
- Even when pot size is not changed, however, these Clerodendrum thomsoniae should be repotted at the end of every rest period. (plantsrescue.com)
- Clerodendrum thomsoniae plants grow outdoors in warm, sheltered and frost-free areas. (plantsrescue.com)
- Clerodendrum thomsoniae plant can be kept pruned into a shrub or given support and allowed to scramble like a vine. (plantsrescue.com)
- Clerodendrum thomsoniae will tolerate full sun with adequate moisture but they will prefer partial shade. (plantsrescue.com)
- Clerodendrum thomsoniae grown in garden like a well-drained soil, rich in organic material. (plantsrescue.com)
- Clerodendrum thomsoniae likes high humidity and a moist, but not soggy, soil. (plantsrescue.com)
Trichotomum2
- Clerodendrum trichotomum is a common ornamental in warmer parts of the world. (wikipedia.org)
- Clerodendrum trichotomum Thunb. (efloras.org)
Genus3
- The type species for the genus is Clerodendrum infortunatum. (wikipedia.org)
- Regional revisions of Clerodendrum have been done for local floras, but the last monograph of the entire genus was by John Isaac Briquet in 1895. (wikipedia.org)
- In 2004, a study of DNA sequences showed that the monospecific Australian genus Huxleya was embedded in a clade of Clerodendrum species that had formerly been placed in Volkameria. (wikipedia.org)
Species3
- Estimates of the number of species in Clerodendrum vary widely, from about 150 to about 450. (wikipedia.org)
- Clerodendrum was named by Linnaeus in Species Plantarum in 1753. (wikipedia.org)
- In 2010, a study of four chloroplast DNA intergenic spacers showed that part of Clerodendrum was closer to the New world genera than to other Clerodendrum, and that one species of Clerodendrum was nested within the clade of New World genera. (wikipedia.org)
Fistulosum2
- Clerodendrum fistulosum and Clerodendrum myrmecophila have hollow stems that are inhabited by ants. (wikipedia.org)
- Clerodendrum fistulosum Becc. (gbif.org)
Evergreen1
- Wild Jasmine (Clerodendrum Inerme) are evergreen mangrove shrubs. (plantsworld.ae)
Description1
- The following description is based on the one by Yuan et alii (2010) and applies to only the monophyletic circumscription of Clerodendrum. (wikipedia.org)
Reports1
- It refers to the considerable variation in reports of the usefulness of Clerodendrum in medicine, and also to the fact the trees were used for religious purposes in Asia. (wikipedia.org)
Serratum5
- The screening of aqueous extract of Clerodendrum serratum revealed its broad-spectrum antimicrobial potential against Gram positive, Gram negative bacteria, and yeast. (nih.gov)
- In this review, an attempt has been made to delineate with pharmacological and phytochemical aspects of Clerodendrum serratum Linn. (journalcra.com)
- Clerodendrum serratum commonly known as Bharangi is traditionally valued and reported for having Bronchodilator, Wound healing, Anti-inflammatory, Anti-oxidant, Anti allergic, anticancer activity. (journalcra.com)
- This review paper highlights the various phytochemical and pharmacological activities of Clerodendrum serratum. (journalcra.com)
- It is blended with ingredients such as Shirish (Albizia lebbeck), Vasa (Adhatoda vasica), Anantamool (Tylphora asthmatica), Dalchini (Cinnamomum zeylanica), Bharangi (Clerodendrum serratum) and Madhuyashti (Glycyrrhiza glabra) that give good result in asthma. (planetayurveda.com)
Bungei7
- I saw Clerodendrum bungei in bloom and had to have this plant in my garden. (californiagardens.com)
- Clerodendrum bungei is not a plant for the timid or the controlled setting. (californiagardens.com)
- Now knowing its character I tried Clerodendrum bungei in a container. (californiagardens.com)
- I cut Clerodendrum bungei to the ground every winter because the tops die back due to our cold nights. (californiagardens.com)
- If you wish to grow Clerodendrum bungei I recommend keeping it in a container in with a drip tray or keeping the container on a paved surface. (californiagardens.com)
- I have not had problems with Clerodendrum bungei going to seed. (californiagardens.com)
- Flowers and foliage of Clerodendrum bungei - Rose Glorybower. (californiagardens.com)
Macrostegium1
- One of these, Clerodendrum macrostegium, suckers abundantly from the roots, often producing a thicket within a few years. (wikipedia.org)
Glorybower1
- Natural News) In some parts of Africa, Clerodendrum polycephalum, commonly known as glorybower or bleeding-heart, has been used traditionally to manage symptoms of sickle cell disease. (naturalnews.com)
Extract1
- 16. Developmental toxicity of Clerodendrum cyrtophyllum turcz ethanol extract in zebrafish embryo. (nih.gov)
Gardens1
- I have several clerodendrum which I originally purchased at Vineyard Gardens. (mvgazette.com)
Flower1
- Pagoda flower ( Clerodendrum buchananii var. (hawaii.edu)
Data1
- In 1997, phylogenetic analysis of DNA data showed that Clerodendrum, as then understood, was polyphyletic. (wikipedia.org)
Leaves2
- 29. An ellagic acid isolated from Clerodendrum viscosum leaves ameliorates iron-overload induced hepatotoxicity in Swiss albino mice through inhibition of oxidative stress and the apoptotic pathway. (nih.gov)
- Translational suppression of SARS-COV-2 ORF8 protein mRNA as a Viable therapeutic target against COVID-19: Computational studies on potential roles of isolated compounds from Clerodendrum volubile leaves. (cdc.gov)