Clemastine
Sneezing
Ketotifen
Pyrrolidines
Histamine H1 Antagonists
Anti-Allergic Agents
Maximal Expiratory Flow Rate
Histamine Antagonists
Common Cold
Aerosols
Clonazepam
Panic Disorder
Lactation
Seizures
Administration of clemastine--H1 histamine receptor blocker in the prevention of haemodynamic disorders after protamine sulfate administration in patients subjected to coronary artery bypass grafting in extracorporeal circulation. (1/25)
INTRODUCTION: Adverse effects of protamine administration after CPB: fall in arterial blood pressure and pulmonary hypertension are still a source of problems. CPB and protamine administration are both accompanied by increased histamine levels in blood. The aim of this study was to examine if clemastine can accelerate the normalisation of arterial blood pressure during the protamine administration after CPB during CABG operations. MATERIAL AND METHODS: Fifty three patients subjected to CABG operations were studied. Control group (n = 27) did not receive clemastine, Clemastine group (n = 26) received 2 mg i.v. clemastine, before CPB. After CPB were completed, patients were given protamine (heparin to protamine ratio--1:1.5) within 7 minutes, through peripheral vein. Changes in arterial blood pressure from the beginning of protamine administration to 2.5, 5, 7.5, 10, 15, and 30 minutes thereafter, as well as heart rate, CVP, doses of inotropic drugs and vasodilators were compared between the groups. RESULTS: No difference in heart rate, CVP, doses of inotropic drugs and vasodilators between the group was noted. An increase in arterial blood pressure 5, 7.5, 10, and 15 minutes after the beginning of the protamine administration were greater in clemastine group than in control group. Groups were comparable with regard to surgical procedures and doses of anaesthetic drugs. It is now known that protamine exerts a negative effect on cardiac contractility either through a decrease in coronary perfusion pressure (vasodilatation), or through a direct toxic effect on cardiac muscle. The administration of clemastine before CPB can reduce peripheral vasodilatation and capillary leak related to histamine release during CPB. In the clemastine group, faster increase in arterial blood pressure toward a physiologic range was observed. We conclude that administration of clemastine is connected with the normalization of ABP during and after protamine reversal of heparin coagulation during CABG operations. (+info)Fatal outcome of a hypersensitivity reaction to paclitaxel: a critical review of premedication regimens. (2/25)
Hypersensitivity reactions (HSRs) to paclitaxel are frequently encountered in patients receiving this antitumour drug. Administration of histamine H1- and H2-receptor antagonists and corticosteroids has been shown to reduce significantly the risk of developing an HSR in patients receiving taxanes. In this case report, we describe the fatal outcome of an HSR in a patient receiving paclitaxel despite short-course premedication. The level of evidence supporting the short-course i.v. premedication schedule is challenged, as it is not compatible with the pharmacokinetic properties of dexamethasone. (+info)Psoriasis vulgaris and digestive system disorders: is there a linkage? (3/25)
(+info)Clemastine potentiates the human P2X7 receptor by sensitizing it to lower ATP concentrations. (4/25)
(+info)Identification and determination of selected histamine antagonists by densitometric method. (5/25)
The conditions for identification were determined for four histamine antagonists: clemastine fumarate, loratadine, cetirizine dihydrochloride and desloratadine by TLC (thin-layer chromatography) method. The selected chromatographic conditions were used to develop a densitometric method for the content determination of the histamine antagonists in medicinal products and substances. The statistical data showed adequate accuracy and precision of the developed methods. (+info)Cimetidine's effect on dermal H1-receptor antagonist tolerance. (6/25)
The effect of the H2-receptor antagonist cimetidine upon H1-receptor antagonist tolerant histamine induced weal and flare responses was studied in nine healthy male subjects taking clemastine 1 mg orally twice a day. After 21 days clemastine therapy, the weal response became tolerant to clemastine but the flare response did not. Cimetidine, 400 mg, did not produce a significantly greater decrease in the area of the H1-receptor antagonist tolerant weal response than in the non-tolerant weal response. The results suggest that histamine mediated skin reactions may develop a tolerance to H1-receptor antagonist therapy that cannot be overcome by the addition of the H2-receptor antagonist cimetidine. (+info)Histamine and allergen induced changes in nasal airways resistance measured by anterior rhinomanometry: reproducibility of the technique and the effect of topically administered antihistaminic and anti-allergic drugs. (7/25)
1. Changes in nasal airways resistance (NAR) following the topical application of histamine and allergen solutions were measured by passive anterior rhinomanometry. 2. The repeatability of five consecutive measurements of resting NAR prior to provocation with histamine or allergen (expressed as the coefficient of variation) was 32.8% and following instillation of saline control solution 37.2%. 3. The repeatability of five consecutive measurements of NAR during the nasal obstruction produced by histamine and allergen was similar to that recorded prior to provocation; the coefficients of variation (median values) being 39.6% and 33.1% respectively. The degree of variability was not related to the dose of agonist or the degree of nasal obstruction. 4. The reproducibility of histamine or allergen induced changes in NAR on four separate weekly occasions showed no significant intra-subject differences. 5. The effects of sodium cromoglycate (SCG), clemastine and ketotifen administered to the nasal mucosa 30 min before provocation with histamine and allergen were compared in a random order, double-blind, placebo controlled study. 6. Clemastine and SCG, but not ketotifen, significantly inhibited the nasal response to increasing concentrations of histamine. None of the drugs administered in the concentrations used in this study significantly inhibited the nasal response to allergen. (+info)Inhaled antihistamines--bronchodilatation and effects on histamine- and methacholine-induced bronchoconstriction. (8/25)
To assess further the bronchodilator activity of inhaled antihistamines ten stable asthmatic subjects inhaled aerosols of clemastine, 1 mg/ml, and saline placebo administered double blind. Subjects underwent bronchial challenge with increasing concentrations of histamine and methacholine, and specific airways conductance was measured by whole body plethysmography at each concentration. There was a significant 21.9% increase in specific airways conductance after inhalation of clemastine. Subjects could tolerate significantly higher mean concentrations of histamine when treated with clemastine than with saline. The shift of the cumulative log histamine dose-reponse curve suggests that such protection is due to competitive antagonism to the inhaled clemastine. Clemastine did not protect subjects against methacholine-induced bronchoconstriction, which suggests that its bronchodilator properties are not related to any anticholinergic action. (+info)Clemastine is a first-generation antihistamine medication that is used to treat allergy symptoms such as runny nose, itching eyes, and sneezing. It works by blocking the action of histamine, a chemical that is released by the body in response to an allergic reaction. Clemastine is available over-the-counter in various forms, including tablets, capsules, and liquid. It is also available by prescription in higher strengths for the treatment of more severe allergy symptoms or for people who do not respond well to over-the-counter antihistamines. Side effects of clemastine may include drowsiness, dry mouth, and blurred vision.
In the medical field, sneezing is a reflex action of the respiratory system that expels air from the lungs through the nose or mouth. It is a protective mechanism that helps to clear the nasal passages of irritants, such as dust, pollen, or viruses, and prevent them from entering the lungs. Sneezing is triggered by the irritation of the nasal passages, which sends a signal to the brain to initiate the sneeze reflex. The muscles in the chest, abdomen, and diaphragm contract, forcing air out of the lungs at a high velocity. This can cause the eyes to water, the nose to run, and the ears to pop. While sneezing is generally a normal and harmless response, it can sometimes be a symptom of an underlying medical condition, such as a cold, allergies, or a respiratory infection. In some cases, excessive or persistent sneezing may require medical attention.
Ketotifen is a medication that is used to treat allergic conditions such as hay fever, allergic rhinitis, and asthma. It belongs to a class of drugs called antihistamines, which work by blocking the action of histamine, a chemical that is released by the body in response to an allergic reaction. Ketotifen is available in both oral and nasal spray forms and is usually taken once or twice a day. It can also be used to prevent eye allergies, such as conjunctivitis, and to treat hives and other skin conditions caused by allergies.
Pyrrolidines are a class of organic compounds that contain a five-membered ring with four carbon atoms and one nitrogen atom. They are commonly used in the medical field as pharmaceuticals, as well as in the synthesis of other drugs and chemicals. One example of a pyrrolidine used in medicine is metoclopramide, which is used to treat nausea and vomiting. Another example is pyrilamine, which is used to treat allergies and hay fever. Pyrrolidines can also be used as chiral auxiliaries in organic synthesis, which allows for the synthesis of enantiomerically pure compounds. This is important in the pharmaceutical industry, as many drugs are effective only when administered in a specific enantiomer. Overall, pyrrolidines are a versatile class of compounds with a wide range of applications in the medical field.
The common cold is a viral infection that affects the upper respiratory tract, including the nose, throat, and sinuses. It is caused by a variety of viruses, including rhinoviruses, coronaviruses, and adenoviruses. The common cold is highly contagious and can be spread through contact with infected individuals or surfaces contaminated with the virus. Symptoms of the common cold typically include a runny or stuffy nose, sore throat, cough, and sometimes fever, body aches, and headaches. The common cold is a self-limiting illness, meaning that it will usually resolve on its own within a week or two without the need for medical treatment. However, over-the-counter medications such as pain relievers, decongestants, and cough suppressants can help alleviate symptoms.
In the medical field, aerosols refer to tiny particles or droplets of liquid or solid matter that are suspended in the air and can be inhaled into the respiratory system. Aerosols can be generated by various sources, including human activities such as talking, coughing, and sneezing, as well as natural phenomena such as volcanic eruptions and dust storms. Aerosols can contain a variety of substances, including bacteria, viruses, fungi, pollutants, and other particles. When inhaled, these particles can enter the lungs and potentially cause respiratory infections, allergies, and other health problems. In the context of infectious diseases, aerosols are of particular concern because they can transmit pathogens over long distances and remain suspended in the air for extended periods of time. To prevent the spread of infectious diseases, it is important to take measures to reduce the generation and dispersion of aerosols in indoor environments, such as wearing masks, practicing good respiratory hygiene, and improving ventilation systems.
Clonazepam is a benzodiazepine medication that is primarily used to treat anxiety disorders, panic disorder, and seizures. It works by enhancing the effects of a neurotransmitter called gamma-aminobutyric acid (GABA) in the brain, which helps to reduce anxiety and calm the nervous system. Clonazepam is available in tablet form and is typically taken orally. The dosage and duration of treatment will depend on the individual's condition and response to the medication. It is important to follow the instructions provided by a healthcare professional and to avoid abruptly stopping the medication, as this can lead to withdrawal symptoms. Clonazepam can have side effects, including drowsiness, dizziness, headache, nausea, and impaired coordination. It can also be habit-forming, and long-term use can lead to dependence and addiction. Therefore, it should only be used under the supervision of a healthcare professional and should be used with caution in individuals with a history of substance abuse or addiction.
Anxiety disorders are a group of mental health conditions characterized by excessive and persistent feelings of worry, fear, and unease. These disorders can interfere with a person's daily life, relationships, and ability to function normally. Anxiety disorders can be classified into several categories, including generalized anxiety disorder, panic disorder, social anxiety disorder, specific phobia, and obsessive-compulsive disorder (OCD). Treatment for anxiety disorders typically involves a combination of medication and therapy, such as cognitive-behavioral therapy (CBT).
Panic disorder is a mental health condition characterized by recurrent and unexpected panic attacks. Panic attacks are sudden and intense episodes of fear, anxiety, and physical symptoms that come on quickly and reach their peak within 10 minutes. During a panic attack, a person may experience symptoms such as a racing heart, sweating, trembling, shortness of breath, chest pain, dizziness, and a sense of impending doom or loss of control. Panic attacks can be very distressing and can lead to avoidance behaviors and a fear of having another attack. Panic disorder is diagnosed when a person experiences at least four panic attacks in a four-week period and is significantly distressed by the attacks or by the fear of having another attack. Treatment for panic disorder typically involves a combination of medication and psychotherapy, such as cognitive-behavioral therapy (CBT).
Seizures are abnormal electrical discharges in the brain that can cause a variety of symptoms, including convulsions, muscle spasms, loss of consciousness, and changes in behavior or sensation. Seizures can be caused by a variety of factors, including brain injury, infection, genetic disorders, and certain medications. They can be classified into different types based on their symptoms and the part of the brain affected. Treatment for seizures may include medications, surgery, or other interventions, depending on the underlying cause and severity of the seizures.
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Antihistamine3
- tell your doctor and pharmacist if you are allergic to clemastine, other antihistamine medications, any other medications, or any of the ingredients in clemastine tablets or liquid. (medlineplus.gov)
- Clemastine is an H1 antihistamine. (canceractive.com)
- A new study paves the way for potential treatments for Multiple Sclerosis (MS) by identifying the OTC antihistamine, clemastine, as an effective drug for brain repair. (neurosciencenews.com)
Myelin2
- In the latest research, with mice, Clemastine caused significant regeneration of the myelin sheath and improved the animals' cognitive function following chemotherapy treatment. (canceractive.com)
- Utilizing a newly-developed MRI scan technique, scientists were able to observe and measure the impact of clemastine on brain myelin levels. (neurosciencenews.com)
Dose1
- If your doctor has told you to take clemastine regularly, take the missed dose as soon as you remember it. (medlineplus.gov)
Brain1
- remyelination, oligodendrocyte differentiation and the increase of neurofilament protein by Clemastine could reduce temporary brain fog, and even more serious damage. (canceractive.com)
Effective1
- Older adults should not usually take clemastine because it is not as safe or effective as other medications that can be used to treat the same condition. (medlineplus.gov)
Older1
- talk to your doctor about the risks and benefits of taking clemastine if you are 65 years of age or older. (medlineplus.gov)
Fumarate11
- Each tablet for oral administration contains 1.34 or 2.68 mg of clemastine fumarate. (nih.gov)
- Clemastine fumarate is an antihistamine with anticholinergic (drying) and sedative side effects. (nih.gov)
- The inherently long duration of antihistaminic effects of clemastine fumarate has been demonstrated in wheal and flare studies. (nih.gov)
- Clemastine Fumarate Tablets 1.34 mg are indicated for the relief of symptoms associated with allergic rhinitis such as sneezing, rhinorrhea, pruritus, and lacrimation. (nih.gov)
- Clemastine Fumarate Tablets 2.68 mg are also indicated for the relief of mild, uncomplicated allergic skin manifestations of urticaria and angioedema. (nih.gov)
- It should be noted that clemastine fumarate is indicated for the dermatologic indications at the 2.68 mg dosage level only. (nih.gov)
- Safety and efficacy of clemastine fumarate have not been established in children under the age of 12 years. (nih.gov)
- Clemastine fumarate should be used with caution in patients with: history of bronchial asthma, increased intraocular pressure, hyperthyroidism, cardiovascular disease, and hypertension. (nih.gov)
- Transient drowsiness, the most common adverse reaction associated with clemastine fumarate, occurs relatively frequently and may require discontinuation of therapy in some instances. (nih.gov)
- Effectiveness of clemastine fumarate for treatment of rhinorrhea and sneezing associated with the common cold. (nih.gov)
- Common side effects of clemastine fumarate include drowsiness, dizziness therefore it gets into the brain. (multiple-sclerosis-research.org)
Antihistamines6
- Clemastine is in a class of medications called antihistamines. (medlineplus.gov)
- It should be noted that the following reactions have occurred with one or more antihistamines and, therefore, should be kept in mind when prescribing drugs belonging to this class, including clemastine. (nih.gov)
- Clemastine belongs to the ethanolamine class of antihistamines (with diphenhydramine and dimenhydrinate) and was first approved for use in the United States in 1977. (nih.gov)
- Despite widespread use, the first generation antihistamines such as clemastine have rarely been linked to liver test abnormalities or to clinically apparent liver injury. (nih.gov)
- 6. The antihistamines clemastine and desloratadine inhibit STAT3 and c-Myc activities and induce apoptosis in cutaneous T-cell lymphoma cell lines. (nih.gov)
- Use of OTC antihistamines like clemastine, loratadine and diphenhydramine also is helpful in the treatment of vasomotor rhinitis. (epainassist.com)
Loratadine1
- A multicentre study of loratadine, clemastine and placebo in patients with perennial allergic rhinitis. (nih.gov)
Antihistamine medications1
- tell your doctor and pharmacist if you are allergic to clemastine, other antihistamine medications, any other medications, or any of the ingredients in clemastine tablets or liquid. (medlineplus.gov)
Drowsiness1
- Alcohol can increase the nervous system side effects of clemastine such as dizziness, drowsiness, and difficulty concentrating. (drugs.com)
Decreases2
- clemastine decreases effects of pitolisant by Other (see comment). (medscape.com)
- Clemastine decreases Aβ generation via reducing the levels of BACE1, CTFs of APP. (nih.gov)
Efficacy1
- Comparative study of the efficacy and tolerance of terfenadine and clemastine in patients with seasonal allergic rhinitis. (nih.gov)
Tablets1
- Clemastine is available in multiple generic forms as tablets and syrup, many of which are available without prescription. (nih.gov)
Allergic rhinitis3
- Clemastine is a first generation antihistamine that is used for symptoms of allergic rhinitis and the common cold. (nih.gov)
- Clemastine (kle mas' teen) is a first generation antihistamine that is used for alleviation of symptoms of allergic rhinitis, the common cold and allergic urticaria, including sneezing, cough, runny note, watery eyes and itching. (nih.gov)
- In the present study, we show clemastine, a first-generation histamine H1R antagonist and being originally marketed for the treatment of allergic rhinitis, ameliorates AD pathogenesis in APP/PS1 transgenic mice. (nih.gov)
Alcohol4
- talk to your doctor about the safe use of alcohol while you are taking clemastine. (medlineplus.gov)
- There is 1 alcohol/food/lifestyle interaction with clemastine. (drugs.com)
- You should avoid or limit the use of alcohol while being treated with clemastine. (drugs.com)
- Clemastine has additive effects with alcohol and other CNS depressants (hypnotics, sedatives, tranquilizers, etc. (nih.gov)
Belongs1
- Clemastine belongs to the benzhydryl ether group of antihistaminic compounds. (nih.gov)
Autophagy3
- Mechanistically, clemastine enhances autophagy concomitant with a suppression of mTOR signaling. (nih.gov)
- Therefore, we propose that clemastine attenuates AD pathology via enhancing mTOR-mediated autophagy. (nih.gov)
- We chose to concentrate on by far the most potent of these, clemastine, an low-cost, extensively available, over-the-counter antihistamine.Clemastine is a host-directed compound that needs host Thymidine-5′-monophosphate (disodium) salt Autophagy macrophages to lower bacterial growthWe found that clemastine consistently reduced mycobacterial development in vivo more than the course of a 5day infectio. (idhinhibitor.com)
Tablet1
- Clemastine comes as a tablet and a liquid to take by mouth. (medlineplus.gov)
Sedation1
- clemastine and olopatadine intranasal both increase sedation. (medscape.com)
Interactions1
- There are 310 drug interactions with clemastine. (drugs.com)
Treatment1
- Chronic treatment with clemastine orally reduced amyloid-β (Aβ) load, neuroinflammation and cognitive deficits of APP/PS1 transgenic mice. (nih.gov)
Years1
- talk to your doctor about the risks and benefits of taking clemastine if you are 65 years of age or older. (medlineplus.gov)
Activity1
- In normal human subjects who received histamine injections over a 24-hour period, the antihistaminic activity of clemastine reached a peak at 5-7 hours, persisted for 10-12 hours and, in some cases, for as long as 24 hours. (nih.gov)
Increase1
- clemastine will increase the level or effect of lonafarnib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (medscape.com)