Clavulanic acids. Medical search

Clavulanic acid and its salts and esters. The acid is a suicide inhibitor of bacterial beta-lactamase enzymes from Streptomyces clavuligerus. Administered alone, it has only weak antibacterial activity against most organisms, but given in combination with other beta-lactam antibiotics it prevents antibiotic inactivation by microbial lactamase.

Acids, salts, and derivatives of clavulanic acid (C8H9O5N). They consist of those beta-lactam compounds that differ from penicillin in having the sulfur of the thiazolidine ring replaced by an oxygen. They have limited antibacterial action, but block bacterial beta-lactamase irreversibly, so that similar antibiotics are not broken down by the bacterial enzymes and therefore can exert their antibacterial effects.

A fixed-ratio combination of amoxicillin trihydrate and potassium clavulanate.

An antibiotic derived from penicillin similar to CARBENICILLIN in action.

A broad-spectrum semisynthetic antibiotic similar to AMPICILLIN except that its resistance to gastric acid permits higher serum levels with oral administration.

Enzymes found in many bacteria which catalyze the hydrolysis of the amide bond in the beta-lactam ring. Well known antibiotics destroyed by these enzymes are penicillins and cephalosporins.

A beta-lactamase inhibitor with very weak antibacterial action. The compound prevents antibiotic destruction of beta-lactam antibiotics by inhibiting beta-lactamases, thus extending their spectrum activity. Combinations of sulbactam with beta-lactam antibiotics have been used successfully for the therapy of infections caused by organisms resistant to the antibiotic alone.

A building block of penicillin, devoid of significant antibacterial activity. (From Merck Index, 11th ed)

Four-membered cyclic AMIDES, best known for the PENICILLINS based on a bicyclo-thiazolidine, as well as the CEPHALOSPORINS based on a bicyclo-thiazine, and including monocyclic MONOBACTAMS. The BETA-LACTAMASES hydrolyze the beta lactam ring, accounting for BETA-LACTAM RESISTANCE of infective bacteria.

Naturally occurring family of beta-lactam cephalosporin-type antibiotics having a 7-methoxy group and possessing marked resistance to the action of beta-lactamases from gram-positive and gram-negative organisms.

Substances that reduce the growth or reproduction of BACTERIA.

A genus of bacteria that form a nonfragmented aerial mycelium. Many species have been identified with some being pathogenic. This genus is responsible for producing a majority of the ANTI-BACTERIAL AGENTS of practical value.

Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).

A group of antibiotics that contain 6-aminopenicillanic acid with a side chain attached to the 6-amino group. The penicillin nucleus is the chief structural requirement for biological activity. The side-chain structure determines many of the antibacterial and pharmacological characteristics. (Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1065)

Cyclic AMIDES formed from aminocarboxylic acids by the elimination of water. Lactims are the enol forms of lactams.

Nonsusceptibility of bacteria to the action of the beta-lactam antibiotics. Mechanisms responsible for beta-lactam resistance may be degradation of antibiotics by BETA-LACTAMASES, failure of antibiotics to penetrate, or low-affinity binding of antibiotics to targets.

A beta-lactamase preferentially cleaving penicillins. (Dorland, 28th ed) EC 3.5.2.-.

Electrophoresis in which a pH gradient is established in a gel medium and proteins migrate until they reach the site (or focus) at which the pH is equal to their isoelectric point.

Single preparations containing two or more active agents, for the purpose of their concurrent administration as a fixed dose mixture.

A group of broad-spectrum antibiotics first isolated from the Mediterranean fungus ACREMONIUM. They contain the beta-lactam moiety thia-azabicyclo-octenecarboxylic acid also called 7-aminocephalosporanic acid.

Semisynthetic, broad-spectrum, AMPICILLIN derived ureidopenicillin antibiotic proposed for PSEUDOMONAS infections. It is also used in combination with other antibiotics.

Beta-lactam antibiotics that differ from PENICILLINS in having the thiazolidine sulfur atom replaced by carbon, the sulfur then becoming the first atom in the side chain. They are unstable chemically, but have a very broad antibacterial spectrum. Thienamycin and its more stable derivatives are proposed for use in combinations with enzyme inhibitors.

Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.

A monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum. It is resistant to beta-lactamases and is used in gram-negative infections, especially of the meninges, bladder, and kidneys. It may cause a superinfection with gram-positive organisms.

Nonsusceptibility of an organism to the action of penicillins.

Gram-negative, non-motile, capsulated, gas-producing rods found widely in nature and associated with urinary and respiratory infections in humans.

Semisynthetic, broad-spectrum antibacterial derived from CEPHALORIDINE and used especially for Pseudomonas and other gram-negative infections in debilitated patients.

One of the PENICILLINS which is resistant to PENICILLINASE.

A penicillin derivative commonly used in the form of its sodium or potassium salts in the treatment of a variety of infections. It is effective against most gram-positive bacteria and against gram-negative cocci. It has also been used as an experimental convulsant because of its actions on GAMMA-AMINOBUTYRIC ACID mediated synaptic transmission.

Therapy with two or more separate preparations given for a combined effect.

A semisynthetic ampicillin-derived acylureido penicillin.

A family of gram-negative, facultatively anaerobic, rod-shaped bacteria that do not form endospores. Its organisms are distributed worldwide with some being saprophytes and others being plant and animal parasites. Many species are of considerable economic importance due to their pathogenic effects on agriculture and livestock.

Semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains. It is stable to beta-lactamases. Clinical studies have demonstrated high efficacy in the treatment of infections of various body systems. Its effectiveness is enhanced when it is administered in combination with CILASTATIN, a renal dipeptidase inhibitor.

Broad-spectrum semisynthetic penicillin derivative used parenterally. It is susceptible to gastric juice and penicillinase and may damage platelet function.

A species of gram-negative, obligately aerobic rods. Motility occurs by peritrichous flagella. (From Bergey's Manual of Determinative Bacteriology, 9th ed)

The ability of bacteria to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).

A genus of gram-negative, facultatively anaerobic, rod-shaped bacteria whose organisms arrange singly, in pairs, or short chains. This genus is commonly found in the intestinal tract and is an opportunistic pathogen that can give rise to bacteremia, pneumonia, urinary tract and several other types of human infection.

A semi-synthetic antibiotic that is a chlorinated derivative of OXACILLIN.

Monocyclic, bacterially produced or semisynthetic beta-lactam antibiotics. They lack the double ring construction of the traditional beta-lactam antibiotics and can be easily synthesized.

Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.

The action of a drug in promoting or enhancing the effectiveness of another drug.

Preliminary administration of a drug preceding a diagnostic, therapeutic, or surgical procedure. The commonest types of premedication are antibiotics (ANTIBIOTIC PROPHYLAXIS) and anti-anxiety agents. It does not include PREANESTHETIC MEDICATION.

Proteins found in any species of bacterium.

Gram-negative bacteria occurring in the lower intestinal tracts of man and other animals. It is the most common species of anaerobic bacteria isolated from human soft tissue infections.

The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).

Infections by bacteria, general or unspecified.

A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.

The functional hereditary units of BACTERIA.

One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

The rate dynamics in chemical or physical systems.

Nonsusceptibility of a microbe to the action of ampicillin, a penicillin derivative that interferes with cell wall synthesis.

A surgical specialty concerned with the diagnosis and treatment of disorders and abnormalities of the COLON; RECTUM; and ANAL CANAL.

A semisynthetic cephamycin antibiotic resistant to beta-lactamase.

A set of genes descended by duplication and variation from some ancestral gene. Such genes may be clustered together on the same chromosome or dispersed on different chromosomes. Examples of multigene families include those that encode the hemoglobins, immunoglobulins, histocompatibility antigens, actins, tubulins, keratins, collagens, heat shock proteins, salivary glue proteins, chorion proteins, cuticle proteins, yolk proteins, and phaseolins, as well as histones, ribosomal RNA, and transfer RNA genes. The latter three are examples of reiterated genes, where hundreds of identical genes are present in a tandem array. (King & Stanfield, A Dictionary of Genetics, 4th ed)

A cephalosporin antibiotic.

Non-susceptibility of an organism to the action of the cephalosporins.

A sulfanilamide that is used as an anti-infective agent.

A species of extremophilic bacteria in the family Thermotogaceae. Generally anaerobic but in the presence of OXYGEN, it can produce hydrogen gas as a byproduct of metabolism.

Broad-spectrum cephalosporin antibiotic resistant to beta-lactamase. It has been proposed for infections with gram-negative and gram-positive organisms, GONORRHEA, and HAEMOPHILUS.

A genus of gram-negative, facultatively anaerobic, rod-shaped bacteria that occurs in the intestines of humans and a wide variety of animals, as well as in manure, soil, and polluted waters. Its species are pathogenic, causing urinary tract infections and are also considered secondary invaders, causing septic lesions at other sites of the body.

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.

Inflammation of the middle ear with purulent discharge.

Semisynthetic broad-spectrum cephalosporin.

A species of gram-negative, facultatively anaerobic, rod-shaped bacteria that occurs in water, sewage, soil, meat, hospital environments, and on the skin and in the intestinal tract of man and animals as a commensal.

A species of gram-negative bacteria causing URINARY TRACT INFECTIONS and SEPTICEMIA.

A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.

Infections with bacteria of the genus BACTEROIDES.

In-vitro susceptibility of 1982 respiratory tract pathogens and 1921 urinary tract pathogens against 19 antimicrobial agents: a Canadian multicentre study. Canadian Antimicrobial Study Group. (1/262)

A total of 3903 pathogens from 48 Canadian medical centres were tested against 19 antimicrobial agents. Five agents showed activity against > or = 90% of all 1982 respiratory tract pathogens tested (ciprofloxacin, 90%; cefoperazone, 91%; ticarcillin/clavulanate, 92%; ceftazidime and imipenem, 93% each). Nine agents had > or = 90% activity against Enterobacteriaceae from respiratory tract infection (cefotaxime and ticarcillin/clavulanate, 90% each; aztreonam, ceftizoxime and ceftriaxone, 91% each; ceftazidime, 93%; ciprofloxacin, 97%; imipenem and netilmicin, 98% each). Similarly, five agents had activity against > or = 90% of all 1921 urinary tract pathogens tested (ciprofloxacin and ticarcillin/clavulanate, 90% each; cefoperazone and netilmicin, 91% each; imipenem, 99%). Nine agents had > or = 95% activity against Enterobacteriaceae from urinary tract infection (ciprofloxacin, 95%; cefotetan, 97%; aztreonam, cefotaxime, ceftazidime, ceftizoxime, ceftriaxone and netilmicin, 98% each; imipenem, 99%). Seventeen agents had activity against > or = 95% of Staphylococcus aureus strains. Susceptibility of Pseudomonas aeruginosa isolates ranged from 2% to 91%. (+info)

Once-daily, high-dose levofloxacin versus ticarcillin-clavulanate alone or followed by amoxicillin-clavulanate for complicated skin and skin-structure infections: a randomized, open-label trial. (2/262)

This study tested whether levofloxacin, at a new high dose of 750 mg, was effective for the treatment of complicated skin and skin-structure infections (SSSIs). Patients with complicated SSSIs (n=399) were randomly assigned in a ratio of 1:1 to 2 treatment arms: levofloxacin (750 mg given once per day intravenously [iv], orally, or iv/orally) or ticarcillin-clavulanate (TC; 3.1 g given iv every 4-6 hours) followed, at the investigator's discretion, by amoxicillin-clavulanate (AC; 875 mg given orally every 12 hours). In the clinically evaluable population, therapeutic equivalence was demonstrated between the levofloxacin and TC/AC regimens (success rates of 84.1% and 80.3%, respectively). In the microbiologically evaluable population, the overall rate of eradication was 83.7% in the levofloxacin treatment group and 71.4% in the TC/AC treatment group (95% confidence interval, -24.3 to -0.2). Both levofloxacin and TC/AC were well tolerated. These data demonstrate that levofloxacin (750 mg once per day) is safe and at least as effective as TC/AC for complicated SSSIs. (+info)

In vitro study of clavulanic acid in combination with penicillin, amoxycillin, and carbenicillin. (3/262)

The activity of clavulanic acid alone and in combination with penicillin, amoxycillin, and carbenicillin was studied. Marked reductions in the minimum inhibitory concentrations (MICs) for a wide spectrum of beta-lactamase-producing clinical isolates were found. Of particular interest were the decreased MICs of penicillin for Bacteroides fragilis and beta-lactamase-producing strains of Neisseria gonorrhoea in the presence of the clavulanic acid. Beta-lactamase-producing strains of Escherichia coli, Klebsiella spp., and indole-negative Proteus also showed considerably increased susceptibility to amoxycillin in combination with clavulanic acid. Two beta-lactamase-producing strains of Pseudomonas aeruginosa remained resistant to carbenicillin in the presence of clavulanic acid. (+info)

Evaluation of ticarcillin/clavulanic acid versus ceftriaxone plus amikacin for fever and neutropenia in pediatric patients with leukemia and lymphoma. (4/262)

BACKGROUND: The empirical use of antibiotic treatments is widely accepted as a means to treat cancer patients in chemotherapy who have fever and neutropenia. Intravenous monotherapy, with broad spectrum antibiotics, of patients with a high risk of complications is a possible alternative. METHODS: We conducted a prospective open-label, randomized study of patients with lymphoma or leukemia who had fever and neutropenia during chemotherapy. Patients received either monotherapy with ticarcillin/clavulanic acid (T) or ceftriaxone plus amikacin (C+A). RESULTS: Seventy patients who presented 136 episodes were evaluated, 68 in each arm of the study. The mean neutrophil counts at admission were 217cells/mm(3) (T) and 201cells/mm(3) (C+A). The mean duration of neutropenia was 8.7 days (T) and 7.6 days (C+A). Treatment was successful without the need for modifications in 71% of the episodes in the T group and 81% in the C+A group (p=0.23). Treatment was considered to have failed because of death in two episodes (3%) in the T group and three episodes (4%) in the C+A group, and because of a change in the drug applied in one episode in the T group and two episodes in the C+A group. Overall success was 96% (T) and 93% (C+A). Adverse events that occurred in group T were not related to the drugs used in this study. CONCLUSION: In pediatric and adolescent patients with leukemia or lymphoma, who presented with fever and neutropenia, during chemotherapy, ticarcillin/clavulanic acid was as successful as the combination of ceftriaxone plus amikacin. It should be considered an appropriate option for this group of patients at high risk for infections. (+info)

Susceptibilities of 540 anaerobic gram-negative bacilli to amoxicillin, amoxicillin-BRL 42715, amoxicillin-clavulanate, temafloxacin, and clindamycin. (5/262)

Agar dilution MIC testing of amoxicillin, amoxicillin-BRL 42715, amoxicillin-clavulanate, temafloxacin, and clindamycin against 496 beta-lactamase-producing anaerobic gram-negative rods revealed MICs for 90% of the strains tested of 256.0 (amoxicillin), 2.0 (amoxicillin-BRL 42715 and amoxicillin-clavulanate), and 4.0 (temafloxacin and clindamycin) microgram/ml. Amoxicillin, temafloxacin, and clindamycin inhibited all 44 beta-lactamase-negative strains (MICs for 90% of the strains tested, less than or equal to 2.0 micrograms/ml). BRL 42715 will not be developed, but temafloxacin merits clinical evaluation. (+info)

Characterization of the Streptomyces clavuligerus argC gene encoding N-acetylglutamyl-phosphate reductase: expression in Streptomyces lividans and effect on clavulanic acid production. (6/262)

The argC gene of Streptomyces clavuligerus encoding N-acetylglutamyl-phosphate reductase (AGPR) has been cloned by complementation of argC mutants Streptomyces lividans 1674 and Escherichia coli XC33. The gene is contained in an open reading frame of 1,023 nucleotides which encodes a protein of 340 amino acids with a deduced molecular mass of 35,224 Da. The argC gene is linked to argE, as shown by complementation of argE mutants of E. coli. Expression of argC from cloned DNA fragments carrying the gene leads to high levels of AGPR in wild-type S. lividans and in the argC mutant S. lividans 1674. Formation of AGPR is repressed by addition of arginine to the culture medium. The protein encoded by the argC gene is very similar to the AGPRs of Streptomyces coelicolor, Bacillus subtilis, and E. coli and, to a lesser degree, to the homologous enzymes of Saccharomyces cerevisiae and Anabaena spp. A conserved PGCYPT domain present in all the AGPR sequences suggests that this may be the active center of the protein. Transformation of S. clavuligerus 328, an argC auxotroph deficient in clavulanic acid biosynthesis, with plasmid pULML30, carrying the cloned argC gene, restored both prototrophy and antibiotic production. (+info)

Broth microdilution testing of Haemophilus influenzae with haemophilus test medium versus lysed horse blood broth. Canadian Haemophilus Study Group. (7/262)

Broth microdilution testing of 702 community-acquired isolates of Haemophilus influenzae from across Canada was performed with both Mueller-Hinton broth supplemented with 3% lysed horse blood broth (LHB) (BBL Microbiology Systems, Cockeysville, Md.) and haemophilus test medium (HTM). The prevalence of beta-lactamase production was found to be 26% with no regional variation. MICs determined with LHB tended to be higher than those with HTM, but interpretive errors due to these differences were observed only rarely with trimethoprim-sulfamethoxazole (n = 5), cefaclor (n = 8), and cefamandole (n = 3). The interobserver variability in MIC determinations was found to be greater when LHB was used than when HTM was used. There was no difference in intraobserver variability between the two medium formulations. beta-Lactamase-positive isolates developed false resistance to amoxicillin-clavulanate 2 weeks after microdilution panels of both types of medium were stored at -20 degrees C but not when panels were stored at -70 degrees C. In conclusion, this study supports the use of HTM rather than LHB for sensitivity testing of H. influenzae because of its lower rate of interobserver variability and its ability to support the growth of these organisms, which is comparable to that of LHB. (+info)

Three-day intravenous triple therapy is not effective for the eradication of Helicobacter pylori infection in patients with bleeding gastro-duodenal ulcer. (8/262)

AIM: To test the efficacy of an ultra-short intravenous triple therapy against Helicobacter pylori infection in patients with bleeding peptic ulcer against standard oral 1-week triple therapy in a randomised, double-blind prospective trial. METHODS: PATIENTS: (n = 75) with haemorrhagic peptic ulcer and H. pylori infection were randomised into: an Intravenous Group to receive omeprazole, clarithromycin and amoxicillin-clavulanic acid intravenously b.d. for 3 days followed by 7 days of oral omeprazole plus placebo of clarithromycin and amoxicillin; an Oral Group to receive intravenous omeprazole plus placebo of clarithromycin and amoxicillin-clavulanic acid followed by 7 days of oral omeprazole, clarithromycin and amoxicillin b.d. Gastric biopsies were obtained for urease test. A 13C-urea breath test was performed to check for H. pylori eradication. RESULTS: Intention-to-treat eradication was 50% (19/38) in the Intravenous Group and 78% (29/37) in the Oral Group (odds ratio 3.63; 95% confidence interval 1.32-9.94; P < 0.01; number needed to treat (NNT) = 4). Per protocol eradication was 50% (14/28) in the Intravenous Group and 86% (24/28) in the Oral Group (P < 0.005). There were no statistically significant differences in adverse events between the two treatment groups. CONCLUSIONS: An ultra-short, 3-day, intravenous, triple therapy containing omeprazole, clarithromycin and amoxicillin-clavulanic acid cannot be recommended as an effective eradication regimen for H. pylori infection related to haemorrhagic gastro-duodenal ulcer. (+info)

It may also increase the risk of yeast infections and, when used in combination with clavulanic acid, diarrhea. It should not ... For this reason, it may be combined with clavulanic acid, a β-lactamase inhibitor. This drug combination is commonly called co- ... Use of the amoxicillin/clavulanic acid combination for more than one week has caused a drug-induced immunoallergic-type ... Cundiff, Jason; Joe, Stephanie (January 2007). "Amoxicillin-clavulanic acid-induced hepatitis". American Journal of ...

https://en.wikipedia.org/wiki/Amoxicillin

This enzyme participates in clavulanic acid biosynthesis. Salowe SP, Krol WJ, Iwata-Reuyl D, Townsend CA (1991). "Elucidation ... CS1 maint: discouraged parameter (link) Townsend CA (2002). "New reactions in clavulanic acid biosynthesis". Curr. Opin. Chem. ... of the gene encoding proclavaminate amidino hydrolase and characterization of protein function in clavulanic acid biosynthesis ...

https://en.wikipedia.org/wiki/Proclavaminate_amidinohydrolase

Townsend CA (October 2002). "New reactions in clavulanic acid biosynthesis". Current Opinion in Chemical Biology. 6 (5): 583-9 ... Clavaminate synthase (EC 1.14.11.21, clavaminate synthase 2, clavaminic acid synthase) is an enzyme with systematic name ... "Structural origins of the selectivity of the trifunctional oxygenase clavaminic acid synthase". Nature Structural Biology. 7 (2 ...

https://en.wikipedia.org/wiki/Clavaminate_synthase

Townsend CA (2002). "New reactions in clavulanic acid biosynthesis". Curr. Opin. Chem. Biol. 6 (5): 583-9. doi:10.1016/S1367- ... This enzyme participates in clavulanic acid biosynthesis. Miller, M. T.; Bachmann, B. O.; Townsend, C. A.; Rosenzweig, A. C. ( ...

https://en.wikipedia.org/wiki/(carboxyethyl)arginine_beta-lactam-synthase

Khaleeli N; Li R; Townsend CA (1999). "Origin of the beta-lactam carbons in clavulanic acid from an unusual thiamine ... This enzyme participates in clavulanic acid biosynthesis. As of late 2007, two structures have been solved for this class of ... the first enzyme in the clavulanic acid biosynthesis pathway". J. Biol. Chem. 279 (7): 5685-92. doi:10.1074/jbc.M310803200. ...

https://en.wikipedia.org/wiki/N2-(2-carboxyethyl)arginine_synthase

Proclavaminate amidinohydrolase is involved in clavulanic acid biosynthesis. Clavulanic acid acts as an inhibitor of a wide ... evolution of a hydrolytic enzyme in clavulanic acid biosynthesis". Biochem. J. 366 (Pt 2): 423. doi:10.1042/BJ20020125. PMC ... Clifton IJ, Elkins JM, Hernandez H (2002). "Oligomeric structure of proclavaminic acid amidino hydrolase: ...

https://en.wikipedia.org/wiki/Ureohydrolase

An example is clavulanic acid, from which this compound class receives its name. Clavulanic acid, a type of Clavam, has ... This class is divided into the clavulanic acid class and the 5S clavams class. Clavulanic acid is a broad-spectrum antibiotic ... Clavulanic acid strongly inhibits b-lactamase in bacteria, which is associated with its antibiotic properties. Different ... Chemical Research Laboratory, Oxford University (The Schofield Group). "Antibiotic Biosynthesis, Clavulanic Acid Mode of Action ...

https://en.wikipedia.org/wiki/Clavam

Baggaley K, Brown A, Schofield C (1997). "Chemistry and biosynthesis of clavulanic acid and other clavams". Nat Prod Rep. 14 (4 ... Tahlan K, Anders C, Jensen S (2004). "The Paralogous Pairs of Genes Involved in Clavulanic Acid and Clavam Metabolite ... Streptomyces clavuligerus is a species of Gram-positive bacterium notable for producing clavulanic acid. S. clavuligerus ATCC ... Kirk S (2000). "The physiology of clavulanic acid production by Streptomyces clavuligerus (PhD thesis)". University of Surrey, ...

https://en.wikipedia.org/wiki/Streptomyces_clavuligerus

"APO-Amoxycillin and Clavulanic Acid 500mg/125 mg Tablets" (PDF). Retrieved November 27, 2014. Mechanism of Action of Bacitracin ... "Amoxicillin-sulbactam versus amoxicillin-clavulanic acid for the treatment of non-recurrent-acute otitis media in Argentinean ... Ceftolozane/tazobactam Fluoroquinolones Piperacillin/tazobactam Ticarcillin/clavulanic acid Antibiotics that cover vancomycin- ... Clindamycin Dalbavancin Fusidic acid Mupirocin (topical) Omadacycline Oritavancin Tedizolid Telavancin Tigecycline (also covers ...

https://en.wikipedia.org/wiki/List_of_antibiotics

Amoxicillin and amoxicillin/clavulanic acid were the most frequently consumed. Antibiotics are screened for any negative ...

https://en.wikipedia.org/wiki/Antibiotic

Cephalosporins, amoxicillin/clavulanic acid, or a fluoroquinolone may also be used. However, antibiotic resistance to ...

https://en.wikipedia.org/wiki/Urinary_tract_infection

Mennink-Kersten MA, Warris A, Verweij PE (2006). "1,3-β-D-Glucan in patients receiving intravenous amoxicillin-clavulanic acid ... increasing fecal bulk and producing short-chain fatty acids as byproducts with wide-ranging physiological activities. This ...

https://en.wikipedia.org/wiki/Beta-glucan

Thus imipenem/cilastatin, like amoxicillin/clavulanic acid, is a commonly used combination product. Keynan S, Hooper NM, Felici ...

https://en.wikipedia.org/wiki/Cilastatin

"X-ray crystal structure of ornithine acetyltransferase from the clavulanic acid biosynthesis gene cluster". Biochem. J. 385 (Pt ...

https://en.wikipedia.org/wiki/ArgJ_protein_family

However, HugA does not affect cephamycins or carbapenems and is inhibited by clavulanic acid. Similar to other Proteus species ... penneri LPS are the amide of D-galacturonic acid with L-lysine α-D-GalA-(L-Lys) (and the amide of D-galacturonic acid with L- ... penneri from the experiment were found to be multiple drug-resistant including resistance to amoxy-clavulanic acid combination ...

https://en.wikipedia.org/wiki/Proteus_penneri

These include ampicillin, chloramphenicol, amoxicillin-clavulanic acid, cefamandole, cefuroxime, cefotaxime, tetracycline, ... "Deoxyribonucleic acid relatedness between Haemophilus aegyptius and Haemophilus influenzae," Elsevier, 137B (1986): 155-163. ...

https://en.wikipedia.org/wiki/Haemophilus_influenzae_biogroup_aegyptius

Bacterial adenoiditis may be treated with antibiotics, such as amoxicillin - clavulanic acid or a cephalosporin. In case of ...

https://en.wikipedia.org/wiki/Adenoiditis

For example, the BAN Co-amoxiclav is assigned to preparations containing amoxicillin and clavulanic acid. Most other ... "amoxicillin with clavulanic acid". The prefix of "co-" is used for many combination drugs, including opioid with paracetamol or ...

https://en.wikipedia.org/wiki/British_Approved_Name

"Simultaneous determination of amoxicillin and clavulanic acid in human plasma by HPLC-ESI mass spectrometry". Journal of ...

https://en.wikipedia.org/wiki/Park_Jong-sei

Brown AG (August 1986). "Clavulanic acid, a novel beta-lactamase inhibitor--a case study in drug discovery and development". ...

https://en.wikipedia.org/wiki/GlaxoSmithKline

Spratt BG, Jobanputra V, Zimmermann W (1977). "Binding of Thienamycin and Clavulanic Acid to the Penicillin-Binding Proteins of ... and l-α-aminoadipic acid by ACV synthetase (ACVS, a nonribosomal peptide synthetase) and then cyclization of this formed ...

https://en.wikipedia.org/wiki/Thienamycin

It is almost always[citation needed] sold and used in combination with clavulanate as ticarcillin/clavulanic acid. Because it ... Ticarcillin is also often paired with a β-lactamase inhibitor such as clavulanic acid (co-ticarclav). In molecular biology, ... One synthesis began by making the monobenzyl ester of 3-Thienylmalonic acid, converting this to the acid chloride with SOCl2, ... and condensing it with 6-Aminopenicillanic acid (6-APA). Hydrogenolysis (Pd/C) completed the synthesis of ticarcillin. Fischer ...

https://en.wikipedia.org/wiki/Ticarcillin

The types of antibiotics that P. oryzihabitans are resistant to ampicillin, amoxicillin-clavulanic acid, and cefazolin. Since ...

https://en.wikipedia.org/wiki/Pseudomonas_oryzihabitans

It is generally resistant to gentamicin and colistin, but sensitive to amoxicillin/clavulanic acid (co-amoxiclav). B. ...

https://en.wikipedia.org/wiki/Melioidosis

In case of systemic infection, other bactericidal antibiotics are used, such as ampicillin, amoxicillin/clavulanic acid, or ... Campylobacter is sensitive to the stomach's normal production of hydrochloric acid: as a result, the infectious dose is ... since this type of medication neutralizes normal gastric acid. In humans, the sites of tissue injury include the jejunum, the ...

https://en.wikipedia.org/wiki/Campylobacter

The first choice is amoxicillin with clavulanic acid, and if the person is penicillin-allergic, doxycycline and metronidazole. ...

https://en.wikipedia.org/wiki/Animal_bite

"Early Bactericidal Activity of Amoxicillin in Combination with Clavulanic Acid in Patients with Sputum Smear-positive Pulmonary ... Amino acid replacements in the NADH binding site of InhA apparently result in INH resistance by preventing the inhibition of ... Mutation in the rpoB gene changes the sequence of amino acids and eventual conformation of the beta subunit. In this case ... p-aminosalicylic acid) For patients with RR-TB or MDR-TB, "not previously treated with second-line drugs and in whom resistance ...

https://en.wikipedia.org/wiki/Multidrug-resistant_tuberculosis

... and clavulanic acid (a β-lactamase inhibitor). The clavulanic acid is designed to overwhelm all β-lactamase enzymes, and ... To overcome this resistance, β-lactam antibiotics can be given with β-lactamase inhibitors such as clavulanic acid. β-lactam ... This is a benefit over clavulanic acid and similar beta-lactam competitors, because they cannot be hydrolysed, and therefore ... Other β-lactamase inhibitors such as boronic acids are being studied in which they irreversibly bind to the active site of β- ...

https://en.wikipedia.org/wiki/Β-lactam_antibiotic

Amoxicillin/clavulanic acid increases the risk of fetal bowel death (necrotizing enterocolitis) and should be avoided in ...

https://en.wikipedia.org/wiki/Prelabor_rupture_of_membranes

"Clavulanic Acid Dehydrogenase: Structural and Biochemical Analysis of the Final Step in the Biosynthesis of the β-Lactamase ... Recent areas of interest include the fat mass and obesity protein which was shown to be a nucleic acid demethylase and JMJD6 ... Inhibitor Clavulanic Acid † , ‡". Biochemistry. 46 (6): 1523-1533. doi:10.1021/bi061978x. PMID 17279617. Borowski, Tomasz; ... Structures of an Oligopeptide-Binding Protein from the Biosynthetic Pathway of the β-Lactamase Inhibitor Clavulanic Acid". ...

https://en.wikipedia.org/wiki/Christopher_J._Schofield

... the IDSA recommends treatment with cefuroxime or amoxicillin/clavulanic acid, as these are effective against both infections.[ ... The spirochetes may also induce host cells to secrete quinolinic acid, which stimulates the NMDA receptor on nerve cells, which ... a derivative of amino acid beta-alanine), oil of lemon eucalyptus (OLE, a natural compound) and OLE's active ingredient para- ...

https://en.wikipedia.org/wiki/Lyme_disease

Amoxicillin/clavulanic acid#. *Imipenem/cilastatin#. *Ampicillin/flucloxacillin. *Ampicillin/sulbactam (Sultamicillin). * ... Cefuroxime is not metabolized, Axetil is metabolized to acetaldehyde and acetic acid. ...

https://en.wikipedia.org/wiki/Cefuroxime_axetil

https://en.wikipedia.org/wiki/Beta-glucans

... amoxicillin/clavulanic acid, or a fluoroquinolone may also be used.[80] However, resistance to fluoroquinolones among the ...

https://en.wikipedia.org/wiki/Urinary_Tract_Infections

Amoxicilină/acid clavulanic# • Imipenem/cilastatin# • Piperacilină/tazobactam# • Ampicilină/flucloxacilină • Ampicilină/ ... Acid 4-aminosalicilic# • Dapsonă# • Clofazimină# • Etambutol# • Pirazinamidă# • Fusafungină • Xibornol • Acid mandelic • ...

https://ro.wikipedia.org/wiki/Aminoglicozidă

Amoxicillin/clavulanic acid#. *Imipenem/cilastatin#. *Imipenem/cilastatin/relebactam. *Ampicillin/flucloxacillin. *Ampicillin/ ... 2S,5R,6R)-3,3-Dimethyl-7-oxo-6-(2-phenylacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid ... Quinolines (e.g., 4-hydroxyquinoline, 4-hydroxyquinoline-3-carboxylic acid, 5,7-CIQA, 7-CIQ, 7-TFQ, 7-TFQA) ...

https://en.wikipedia.org/wiki/Benzylpenicillin

alpha hydroxy acid: ماندلیک اسید. *کوینولین: Nitroxoline. *pyran/fatty acid: Isoleucine-tRNA ligase inhibitors (موپیروسین) ...

https://azb.wikipedia.org/wiki/اسپکتینومایسین

Penicillin and penicillin-derived antibiotics can thus be combined with a beta-lactamase inhibitor such as clavulanic acid or ...

https://en.wikipedia.org/wiki/Lemierre's_syndrome

... oct-2-ene-2-carboxylic acid, اینگیلیسجه: Ceftriaxone, (چینجه:頭孢曲松‎)، عربجه: سيفترياكسون‎، روسجا: Цефтриаксон) بیر شیمیایی ...

https://azb.wikipedia.org/wiki/سفتریاکسون

Amoxicillin/clavulanic acid#. *Imipenem/cilastatin#. *Ampicillin/flucloxacillin. *Ampicillin/sulbactam (Sultamicillin). * ...

https://en.wikipedia.org/wiki/Meropenem

Amoxicillin/clavulanic acid#. *Imipenem/cilastatin#. *Ampicillin/flucloxacillin. *Ampicillin/sulbactam (Sultamicillin). * ... 5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid ...

https://en.wikipedia.org/wiki/Cefetamet

Amoxicillin/clavulanic acid#. *Imipenem/cilastatin#. *Imipenem/cilastatin/relebactam. *Ampicillin/flucloxacillin. *Ampicillin/ ... 2S,5R,6R)-6-[(2-ethoxy-1-naphthoyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid ...

https://en.wikipedia.org/wiki/Nafcillin

Amoxicillin/clavulanic acid. *Amphotericin B. *Ampicillin. *Anastrozole. *Anti-tetanus immunoglobulin. *Antivenom. *Aprepitant ...

https://en.wikipedia.org/wiki/Category:World_Health_Organization_essential_medicines

Amoxicillin/clavulanic acid. Molimo Vas, obratite pažnju na važno upozorenje. u vezi sa temama iz oblasti medicine (zdravlja). ...

https://sr.wikipedia.org/wiki/Amoksicilin/klavulanska_kiselina

CLAVULANIC ACID 118. CLIDINIUM BROMIDE 119. CLINDAMYCIN 120. CLOBAZAM 121. CLOBETASOL PROPENATE ...

https://en.wikipedia.org/wiki/Schedule_H

Amoxicillin/clavulanic acid (amoxicillin + clavulanic acid). *Ampicillin. *Benzathine benzylpenicillin. *Benzylpenicillin. * ... Acetylsalicylic acid (aspirin)[note 90]. Notes[edit]. An α indicates the medicine is only on the complementary list. For these ... Solutions correcting water, electrolyte and acid-base disturbances[edit]. Oral[edit]. *Oral rehydration salts ...

https://en.wikipedia.org/wiki/List_of_World_Health_Organization_Essential_Medicines

penam (Sulbactam, Tazobactam) • clavam (Clavulanic acid). Combinations. Co-amoxiclav (Amoxicillin/clavulanic acid)# • Imipenem/ ...

https://sq.wikipedia.org/wiki/Stampa:Penicillin

clavulanic acid. *Eminase (anistreplase). *Engerix-B (hepatitis B vaccine). *Floxapen (flucloxacillin). *granisetron ... 6-aminopenicillanic acid);[7] This discovery allowed Beecham, working in tandem with Bristol-Myers, to synthesize of a number ... "Synthesis of Penicillin: 6-Aminopenicillanic Acid in Penicillin Fermentations" (PDF). Nature ...

https://en.wikipedia.org/wiki/Beecham_

"In vitro activity of amoxicillin in combination with clavulanic acid against Mycobacterium tuberculosis". Antimicrob. Agents ...

https://sh.wikipedia.org/wiki/Amoksicilin

... susceptible to clavulanic acid. The homology is 43% between protein sequences CepA and CblA and 51% between nucleotide ... and amoxicillin combined with clavulanic acid.[9] Although resistant strains are most frequently isolated in oral cavities, ... intermedia by a substitution of one amino acid (Y239D). CfxA3 was different from CfxA2 because of an aspartic acid in place of ... vulgatus by substitution of two amino acids (K272E and Y239D) and from cfxA2 gene of P. ...

https://en.m.wikipedia.org/wiki/Capnocytophaga

... ceftibuten and amoxicillin/clavulanic acid) or with short courses (2 to 4 days) of intravenous therapy followed by oral therapy ... "Update on dimercaptosuccinic acid renal scanning in children with urinary tract infection" (April 1995). Pediatr. Nephrol. 9: ... DMSA စကင် (DMSA scan) ဆိုသည်မှာ ဒိုင်မာကပ်တိုဆတ်ဆီးနစ် အက်ဆစ် (dimercaptosuccinic acid) ကို အသုံးပြုထားသော ရေဒီယိုနြူကလိရိုက် ...

https://my.wikipedia.org/wiki/ကျောက်ကပ်ရောင်ရောဂါ

Amoxicillin/clavulanic acid#. *Imipenem/cilastatin#. *Ampicillin/flucloxacillin. *Ampicillin/sulbactam (Sultamicillin). * ... Phenoxymethylpenicillin is more acid-stable than benzylpenicillin, which allows it to be given orally. ... 3,3-Dimethyl-7-oxo-6-(2-phenoxyacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid ...

https://en.wikipedia.org/wiki/Phenoxymethylpenicillin

Amoxicillin/clavulanic acid#. *Imipenem/cilastatin#. *Ampicillin/flucloxacillin. *Ampicillin/sulbactam (Sultamicillin). * ... This binding of vancomycin to the D-Ala-D-Ala prevents cell wall synthesis of the long polymers of N-acetylmuramic acid (NAM) ... Before vancomycin is assembled through NRPS, the amino acids are first modified. L-tyrosine is modified to become the β- ... Nonribosomal peptide synthesis occurs through distinct modules that can load and extend the protein by one amino acid through ...

https://en.wikipedia.org/wiki/Vancomycin_hydrochloride

... amoxicillin/clavulanic acid) were 13.7 versus 17.7%, and 9.5 versus 13.2%, respectively. However, many of these reported ... 5-Amino-1-cyclopropyl-7-[(3R,5S)3,5-dimethylpiperazin-1-yl]-6,8-difluoro-4-oxo-quinoline-3-carboxylic acid ...

https://en.wikipedia.org/wiki/Sparfloxacin

Use of clavulanic acid or tazobactam, beta-lactamase inhibitors, alongside penicillin gives penicillin activity against beta- ... The first step is the condensation of three amino acids-L-α-aminoadipic acid, L-cysteine, L-valine into a tripeptide.[63][64][ ... α-ketoglutarate + AcCoA → homocitrate → L-α-aminoadipic acid → L-lysine + β-lactam. The by-product, .mw-parser-output span. ... This targeted protonation neutralizes the carboxylic acid moiety, which is weakening of the β-lactam ring N-C(=O) bond, ...

https://en.m.wikipedia.org/wiki/Penicillin

Amoxicillin/clavulanic acid. *Amphotericin B. *Ampicillin. *Ampicillin/sulbactam. *Ampyzine. *Amyl nitrite. *Anabasine ...

https://en.wikipedia.org/wiki/Category:Drugboxes_which_contain_changes_to_watched_fields

... mild low-risk cases may be treated with a combination of oral amoxicillin-clavulanic acid and ciprofloxacin, while more severe ... or piperacillin/tazobactam for high-risk patients and amoxicillin-clavulanic acid and ciprofloxacin for low-risk patients. ...

https://en.wikipedia.org/wiki/Febrile_neutropenia

These medications include: Amoxicillin (excluding Amoxicillin/clavulanic acid) Ampicillin Penicillin VK and Sulfamethoxazole- ...

https://en.wikipedia.org/wiki/Publix

Combined with the antibiotic, clavulanic acid can overcome drug resistance. Source for information on clavulanic acid: A ... clavulanic acid (klav-yoo-lan-ik) n. a drug that interferes with the enzymes (penicillinases) that inactivate many penicillin- ... Combined with the antibiotic, clavulanic acid can overcome drug resistance.. Cite this article Pick a style below, and copy the ... clavulanic acid (klav-yoo-lan-ik) n. a drug that interferes with the enzymes (penicillinases) that inactivate many penicillin- ...

https://www.encyclopedia.com/caregiving/dictionaries-thesauruses-pictures-and-press-releases/clavulanic-acid

... ticarcillin and clavulanic acid. Ticarcillin is a penicillin-type antibiotic, and clavulanic acid is a medicine that prevents ... Timentin (ticarcillin, clavulanic acid). Timentin injection contains two active ingredients, ticarcillin and clavulanic acid. ... ticarcillin and clavulanic acid. Ticarcillin is a penicillin-type antibiotic, and clavulanic acid is a medicine that prevents ... Clavulanic acid is a type of medicine known as a beta-lactamase inhibitor. It is included in this medicine because it inhibits ...

https://www.netdoctor.co.uk/medicines/infection/a7653/timentin-ticarcillin-clavulanic-acid/

Amoxicillin/clavulanic acid. Acute generalised exanthematous pustulosis: case report. Reactions Weekly volume 1283, page11(2010 ... in a child after the administration of amoxicillin-clavulanic acid: brief report. Pediatric Dermatology 26: 623-625, No. 5, Oct ... Amoxicillin/clavulanic acid. React. Wkly. 1283, 11 (2010). https://doi.org/10.2165/00128415-201012830-00038 ...

https://link.springer.com/article/10.2165%2F00128415-201012830-00038

A list of US medications equivalent to Clavulanic Acid is available on the Drugs.com website. ... Clavulanic Acid is a medicine available in a number of countries worldwide. ... Te Di (Clavulanic Acid and Amoxicillin). New Asiatic Pharm, China. *Teva-Amoxicillin Clavulanic Acid (Clavulanic Acid and ... APO-Amoxycillin and Clavulanic Acid (Clavulanic Acid and Amoxicillin). Apotex, Australia. *Arcef-CV (Clavulanic Acid and ...

https://www.drugs.com/international/clavulanic-acid.html

Amoxicillin and Clavulanic Acid: learn about side effects, dosage, special precautions, and more on MedlinePlus ... The 250 mg and 500 mg tablets of amoxicillin and clavulanic acid contain the same amount of clavulanic acid. Do not substitute ... clavulanic acid, penicillin, cephalosporins, any other medications, or any of the ingredients in amoxicillin and clavulanic ... Take amoxicillin and clavulanic acid exactly as directed. Do not take more or less of it or take it more often than prescribed ...

https://medlineplus.gov/druginfo/meds/a685024.html

Reddit gives you the best of the internet in one place. Get a constantly updating feed of breaking news, fun stories, pics, memes, and videos just for you. Passionate about something niche? Reddit has thousands of vibrant communities with people that share your interests. Alternatively, find out whats trending across all of Reddit on r/popular. Reddit is also anonymous so you can be yourself, with your Reddit profile and persona disconnected from your real-world identity.

https://www.reddit.com/r/AugmentinRx/

Emphasizes the medications amoxicillin and clavulanic acid (Amoclan, Augmentin, Augmentin XR, Augmentin ES-600), which are ... amoxicillin and clavulanic acid. *What is Augmentin (amoxicillin and clavulanic acid)? How does it work? ... Amoxicillin and clavulanic acid (Augmentin Amoclan, Augmentin XR, Augmentin ES-600) is a penicillin type antibiotic prescribed ... Clavulanic acid enhances the effectiveness of amoxicillin against bacteria that are ordinarily resistant to amoxicillin alone. ...

https://www.medicinenet.com/amoxicillin_and_clavulanic_acid/article.htm

Clavulanic acid was patented in 1974. Amoxicillin-clavulanic acid is a first-line treatment for many types of infections, ... which produces clavulanic acid. The β-lactam like structure of clavulanic acid looks structurally similar to penicillin, but ... which is the first step of the clavulanic acid biosynthesis. Clavulanic acid was discovered around 1974-75 by British ... This restructures the clavulanic acid molecule, creating a much more reactive species that attacks another amino acid in the ...

https://en.wikipedia.org/wiki/Clavulanic_acid

Amoxicillin/clavulanic-acid/epinephrine. Anaphylaxis and Kounis syndrome type II: case report ...

https://link.springer.com/article/10.1007%2Fs40278-019-71522-x

Clavulanic acids synonyms, Clavulanic acids pronunciation, Clavulanic acids translation, English dictionary definition of ... Clavulanic acids. n. A compound, C8H9NO5, originally obtained from the bacterium Streptomyces clavuligerus, that inhibits ... clavulanic acid. (redirected from Clavulanic acids). Also found in: Medical.. Related to Clavulanic acids: Augmentin, Co- ... Clavulanic acids - definition of Clavulanic acids by The Free Dictionary https://www.thefreedictionary.com/Clavulanic+acids ...

https://www.thefreedictionary.com/Clavulanic+acids

Home › Q & A › Questions › Amoxicillin and clavulanic.... Amoxicillin and clavulanic acid and then take cephalexin?. Asked. 22 ... Can Amoxicillin/Clavulanic Acid 875/125 Mg cause double vision?. Posted 12 Dec 2010 • 1 answer ... Prescribed amoxicillin and clavulanic 825mg/125mgI have three left.. Due to public holiday and long weekend unable to get to ...

https://www.drugs.com/answers/amoxicillin-clavulanic-acid-cephalexin-3358604.html

Side Effects of Clavulanic Acid. Clavulanic acid is generally a safe drug. The first doses can cause vomit, diarrhea and ... Administration of Clavulanic Acid. When you start administering amoxicillin and clavulanic acid to your dog, you should respect ... Canine Staph Infection Treatment with Clavulanic Acid. Amoxicillin and clavulanic acid are used efficiently in treating ... Clavulanic acid is a synthetic substance which functions together with beta-lactam antibiotics to fight bacteria with high ...

https://www.vetinfo.com/canine-staph-infection-treatment-with-clavulanic-acid.html

Clavulanic acid biosynthesis synonyms, Clavulanic acid biosynthesis pronunciation, Clavulanic acid biosynthesis translation, ... English dictionary definition of Clavulanic acid biosynthesis. n. A compound, C8H9NO5, originally obtained from the bacterium ... clavulanic acid. (redirected from Clavulanic acid biosynthesis). Also found in: Medical. clav·u·lan·ic acid. (klăv′yo͝o-lăn′ĭk) ... Clavulanic acid biosynthesis - definition of Clavulanic acid biosynthesis by The Free Dictionary https://www.thefreedictionary. ...

https://www.thefreedictionary.com/Clavulanic+acid+biosynthesis

Amoxycillin-Clavulanic Acid-Related Tooth Discoloration in Children. M. Garcia-López, M. Martinez-Blanco, I. Martinez-Mir, V. ... Amoxycillin-Clavulanic Acid-Related Tooth Discoloration in Children. M. Garcia-López, M. Martinez-Blanco, I. Martinez-Mir, V. ... Amoxycillin-Clavulanic Acid-Related Tooth Discoloration in Children. M. Garcia-López, M. Martinez-Blanco, I. Martinez-Mir and V ... Amoxycillin-Clavulanic Acid-Related Tooth Discoloration in Children Message Subject (Your Name) has sent you a message from ...

https://pediatrics.aappublications.org/content/108/3/819.2

... diagnosed with symmetrical drug related intertriginous and flexural exanthema after she received amoxicillin/clavulanic acid ...

http://connection.ebscohost.com/c/articles/89657279/amoxicillin-clavulanic-acid

Increased amoxicillin-clavulanic acid resistance in Escherichia coli blood isolates, Spain.. Oteo J1, Campos J, Lázaro E, ... Evolution of amoxicillin-clavulanic acid nonsusceptibility of Escherichia coli from blood isolates, Spain, 2003-2006. ESBL, ... Increased Amoxicillin-Clavulanic Acid Resistance in Escherichia coli Blood Isolates, Spain. Emerg Infect Dis. 2008 Aug;14(8): ... Increased Amoxicillin-Clavulanic Acid Resistance in Escherichia coli Blood Isolates, Spain. Emerg Infect Dis. 2008 Aug;14(8): ...

https://www.ncbi.nlm.nih.gov/pubmed/18680650?dopt=Abstract

Acids, Clavulanic. Acids, Salts, and derivatives of Clavulanic Acid (C8H9O5N). They consist of those beta-lactam compounds that ...

http://www.online-medical-dictionary.org/definitions-a/acids-clavulanic.html

Clavulanic Acids ← Clavulanic Acid 2.. Chemicals ← Heterocyclic Compounds ← Heterocyclic Compounds, Fused-Ring ← Heterocyclic ... Clavulanic Acid, Monopotassium Salt , Clavulanic Acid, Monosodium Salt , MM14151 , MM 14151 , MM-14151 , Potassium Clavulanate ... Clavulanic Acid CAS Type 1 Name 4-Oxa-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3-(2-hydroxyethylidene)-7-oxo-, (2R-(2alpha ...

http://ctd.mdibl.org/detail.go?type=chem&acc=D019818

Clavulanic Acid (Clavulanate Potassium) 57 mg / 5 ml*Syrup; Oral; Amoxicillin Trihydrate 125 mg; Clavulanic Acid (Clavulanate ... Clavulanic Acid (Clavulanate Potassium) 28.75 mg / 5 ml*Tablets; Oral; Amoxicillin Trihydrate 500 mg; Clavulanic Acid ( ...

https://drugs-about.com/drugs-a/augmentin-duo.html

Injectable; Injection; Amoxicillin 1 g; Clavulanic Acid 200 mg*Tablets; Oral; Amoxicillin 500 mg; Clavulanic Acid 125 mg. ...

http://drugs-about.com/drugs-c/clamox-inga-laboratories.html

... clavulanic acid including side effects, age restrictions, food interactions, whether the medicine is available at a government ... clavulanic acid. The medicines below all contain the following active ingredient(s): amoxicillin + clavulanic acid. You can ... Amoxycillin and Clavulanic Acid 500/125 (Apo). *Amoxycillin/Clavulanic Acid 500/125 (Generic Health) ... Amoxycillin/Clavulanic Acid 875/125 (Actavis). *Amoxycillin and Clavulanic Acid 875/125 (GenRx) ...

https://www.healthdirect.gov.au/medicines/medicinal-product/aht,23166/amoxicillin-+-clavulanic-acid

Amoxycillin and clavulanic acid-induced stevens-johnson syndrome in a dialysis patient. International Journal of Research in ... Amoxicillin/clavulanic-acid. Stevens johnson syndrome with toxic epidermal necrolysis: case report ... Amoxicillin/clavulanic-acid. Reactions Weekly 1843, 27 (2021). https://doi.org/10.1007/s40278-021-91129-5 ...

https://rd.springer.com/article/10.1007/s40278-021-91129-5?error=cookies_not_supported&code=b48a7440-e08f-4766-9804-a685b151928e

Read more about the prescription drug AMOXICILLIN/CLAVULANIC ACID 500 MG/125 MG - ORAL. ... Consumer information about the medication AMOXICILLIN/CLAVULANIC ACID 500 MG/125 MG - ORAL (Augmentin), includes side effects, ... amoxicillin/clavulanic acid 500 mg/125 mg - oral, Augmentin. GENERIC NAME: AMOXICILLIN/CLAVULANIC ACID 500 MG/125 MG - ORAL (a- ... USES: Amoxicillin/clavulanic acid is a penicillin-type antibiotic used to treat a wide variety of bacterial infections. It ...

https://www.medicinenet.com/amoxicillinclavulanic_acid_tablet_500mg125mg/article.htm

Severe neutropenia during treatment with amoxicillin/clavulanic acid in a patient on regular hemodialysis treatment]. Giornale ...

https://rd.springer.com/article/10.1007/s40278-018-43432-9

... amoxycillin and clavulanic acid powder for oral suspension) intended for persons living in Australia. ... and clavulanic acid (as potassium clavulanate). Amoxycillin belongs to the penicillin group of antibiotics. Clavulanic acid is ... acid (as potassium clavulanate). Each 5mL of APO-Amoxycillin and Clavulanic Acid 125/31.25 suspension contains 125mg of ... APO-Amoxycillin and Clavulanic Acid Suspension contains aspartame.. Tell your doctor if your childs urine has to be tested for ...

https://www.news-medical.net/drugs/APO-AmoxycillinClavulanic-Acid-Suspension.aspx

The ability of clavulanic acid and sulbactam to induce and inhibit cephalosporinases was evaluated in 16 clinical isolates of ... Differences between clavulanic acid and sulbactam in induction and inhibition of cephalosporinases in enterobacteria.. ... This variation in effect was probably due to the fact that sulbactam, but not clavulanic acid could inhibit cephalosporinases. ... Antagonism was achieved using a combination of clavulanic acid and cefotaxime but a combination of sulbactam and cefotaxime was ...

https://www.ncbi.nlm.nih.gov/pubmed/2282971?dopt=Abstract

Amoxicillin; Clavulanic Acid oral suspension. What is this medicine?. AMOXICILLIN; CLAVULANIC ACID (a mox i SILL in; KLAV yoo ... an unusual or allergic reaction to amoxicillin, penicillin, cephalosporin, other antibiotics, clavulanic acid, other medicines ...

http://www.ahealthyme.com/Library/DiseasesConditions/Adult/Surgical/121,471

Amoxicillin; Clavulanic Acid extended-release tablets. What is this medicine?. AMOXICILLIN; CLAVULANIC ACID (a mox i SILL in; ... an unusual or allergic reaction to amoxicillin, penicillin, cephalosporin, other antibiotics, clavulanic acid, other medicines ...

http://www.ahealthyme.com/RelatedItems/121,470

On this page about Amoxycillin and Clavulanic Acid 125/31.25 (Apo) you will find information relating to side effects, age ... Active ingredients: amoxicillin + clavulanic acid On April 1, 2020 Amoxycillin and Clavulanic Acid 125/31.25 (Apo) was not ... Other medicines containing the same active ingredients: amoxicillin + clavulanic acid *Can I take Amoxycillin and Clavulanic ... Brand name: Amoxycillin and Clavulanic Acid 125/31.25 (Apo) TM. ... Acid 125/31.25 (Apo) in sport? Find out on the ASADA website ...

https://www.healthdirect.gov.au/medicines/brand/amt,690741000168104/amoxycillin-and-clavulanic-acid-125-31-25-apo

Clavulanic acid (Science: chemical) clavulanic acid (c8h9o5n) and its salts and esters. The acid is a suicide inhibitor of ... chemical name: 4-Oxa-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3-(2-hydroxyethylidene)-7-oxo-, (2R-(2alpha,3Z,5alpha)) ... Retrieved from "https://www.biology-online.org/dictionary/index.php?title=Clavulanic_acid&oldid=12551" ...

https://www.biology-online.org/dictionary/Clavulanic_acid

The combination of amoxicillin and clavulanic acid is used to treat certain infections caused by bacteria, including infections of the ears, lungs, sinus, skin, and urinary tract. (medlineplus.gov)
The combination of amoxicillin and clavulanic acid comes as a tablet, a chewable tablet, an extended-release (long-acting) tablet, and a suspension (liquid) to take by mouth. (medlineplus.gov)
Take amoxicillin and clavulanic acid exactly as directed. (medlineplus.gov)
The 250 mg and 500 mg tablets of amoxicillin and clavulanic acid contain the same amount of clavulanic acid. (medlineplus.gov)
Take amoxicillin and clavulanic acid until you finish the prescription, even if you feel better. (medlineplus.gov)
If you stop taking amoxicillin and clavulanic too soon, or skip doses, your infection may not be completely treated and the bacteria may become resistant to antibiotics. (medlineplus.gov)
Amoxicillin and clavulanic acid also is used sometimes to treat certain sexually transmitted diseases (STD). (medlineplus.gov)
tell your doctor and pharmacist if you are allergic to amoxicillin (Amoxil, Trimox, Wymox), clavulanic acid, penicillin, cephalosporins, any other medications, or any of the ingredients in amoxicillin and clavulanic acid preparations. (medlineplus.gov)
you should know that amoxicillin and clavulanic acid may decrease the effectiveness of oral contraceptives (birth control pills). (medlineplus.gov)
Plan to use another form of birth control while taking amoxicillin and clavulanic acid. (medlineplus.gov)
If you become pregnant while taking amoxicillin and clavulanic acid, call your doctor. (medlineplus.gov)
Amoxicillin and clavulanic acid may cause side effects. (medlineplus.gov)
What is Augmentin (amoxicillin and clavulanic acid)? (medicinenet.com)
Amoxicillin and clavulanic acid (Augmentin Amoclan, Augmentin XR, Augmentin ES-600) is a penicillin type antibiotic prescribed for the treatment of middle ear infections, sore throat , sinus infection , bronchitis , pneumonia , and urinary tract infections . (medicinenet.com)
Amoxicillin and clavulanic acid and then take cephalexin? (drugs.com)
Prescribed amoxicillin and clavulanic 825mg/125mgI have three left. (drugs.com)
Amoxicillin and clavulanic acid are used efficiently in treating staphylococcus infections in dogs. (vetinfo.com)
The combination of amoxicillin and clavulanic acid helps fight bacteria and staphylococci, which are otherwise resistant to antibiotics belonging to the penicillin group. (vetinfo.com)
When you start administering amoxicillin and clavulanic acid to your dog, you should respect your veterinarian's prescription. (vetinfo.com)
age range, 1 month to 15 years) treated with amoxicillin and clavulanic acid, respectively. (ugent.be)
The typical population values of clearance for amoxicillin and clavulanic acid were 17.97 liters/h/70 kg and 12.20 liters/h/70 kg, respectively. (ugent.be)
Monte Carlo simulations demonstrated that four-hourly dosing of 25 mg/kg was required to achieve the therapeutic target for both amoxicillin and clavulanic acid. (ugent.be)
Stopping amoxicillin and clavulanic acid too soon may cause bacteria to become resistant to antibiotics. (hellodoktor.com)
The results clearly show that adjusting for these factors further increases the relative risk of acute liver injury associated with the combination of amoxicillin and clavulanic acid. (jamanetwork.com)

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Clavulanic acid has negligible intrinsic antimicrobial activity, despite sharing the β-lactam ring that is characteristic of β-lactam antibiotics. (wikipedia.org)
clavulanic acid (klav-yoo- lan -ik) n. a drug that interferes with the enzymes (penicillinases) that inactivate many penicillin-type antibiotics, such as amoxicillin. (encyclopedia.com)
Clavulanic acid is a synthetic substance which functions together with beta-lactam antibiotics to fight bacteria with high resistance to other antibiotics. (vetinfo.com)
The clavulanic acid molecule interacts with the enzyme secreted by beta-lactamase bacteria which makes them resistant to other beta-lactam antibiotics. (vetinfo.com)
The data revealed a significant difference between sulbactam and clavulanic acid, which may have relevance to their relative usefulness in combination with beta-lactam antibiotics for the treatment of infections due to enterobacteria that produce inducible cephalosporinase. (nih.gov)
Augmentin Medicine 1g 625mg Amoxycillin & Clavulanic Acid antibiotics for bacterial infections. (index-china.com)
METHODS: 138 children, ranging in age from 2 to 16 years, with ReA of up to 3 months duration were randomly assigned to 3 groups and either prescribed antibacterial treatment with amoxicillin or amoxicillin + clavulanic acid (amoxicillin-potassium clavulanate combination) or were not given antibiotics (control group). (prohealth.com)
When used in combination with conventional β-lactam antibiotics, clavulanic acid provides a powerful tool to combat infections by antibiotic-resistant pathogens. (asm.org)
Clavulanic acid (CA) is a potent inhibitor of β-lactamases, enzymes synthesized by some gram-positive and gram-negative bacteria, which provide them a defense mechanism against β-lactam antibiotics. (scielo.org.co)
Clavulanate lithium (clavulanic acid) is a β-lactamase inhibitor which can irreversibly inactivate β-lactamase enzymes of β-lactam resistant microbes preventing them from breaking down β-lactam antibiotics. (toku-e.com)
β-lactam antibiotics, such as penicillin, can be combined with clavulanic acid for greater efficacy against β-lactam resistant strains. (toku-e.com)
Like other β-lactam antibiotics, the chemical structure of clavulanic acid contains a β-lactam ring allowing it to act as a β-lactamase inhibitor. (toku-e.com)

Combined with the antibiotic, clavulanic acid can overcome drug resistance . (encyclopedia.com)
Ticarcillin is a penicillin-type antibiotic, and clavulanic acid is a medicine that prevents bacteria from inactivating the ticarcillin. (netdoctor.co.uk)
The clavulanic acid actually destroys the enzyme which protects bacteria from the effect of the antibiotic. (vetinfo.com)
Amoxicillin /clavulanic acid is a penicillin-type antibiotic used to treat a wide variety of bacterial infections . (medicinenet.com)
Clavulanic Acid is a beta-lactamase inhibitor that reduces resistance and enhances the activity of Amoxycillin against antibiotic-resistant bacteria. (index-china.com)
The commercial β-lactamase inhibitors (clavulanic acid [CLA], tazobactam, and sulbactam) generally have low antibiotic activity against most microorganisms and therefore are not used alone as antimicrobial agents. (asm.org)
In 32% of the treated patients, amoxicillin-clavulanic acid therapy was stopped prematurely due to clinical failure, and the patient was switched to broader-spectrum antibiotic treatment. (ugent.be)
Amoxicillin/clavulanic acid, also known as co-amoxiclav, is an antibiotic useful for the treatment of a number of bacterial infections. (spectroom.com)
Curam Duo (Amoxicillin/Clavulanic Acid) is an oral penicillin antibiotic prescribed to treat a wide variety of bacterial infections including those affecting the soft tissues, middle ear, respiratory tract, abdomen, blood, or heart. (4nrx-uk.md)

Tablets: 250/125 mg (amoxicillin/clavulanic), 500/125, and 875/125 mg. (medicinenet.com)
Linezolid was given as 600 mg tablets b.i.d. for 7 d and amoxicillin/clavulanic acid as 1000 mg tablets o.d. for 7 d. (nih.gov)
What is consult with acid indigestion character and box obs for tablets provide why do take to of acid and ingrown. (atspace.com)
Skin, sinus, ears, lungs and many others are more inclined to get infected by bacteria, for which Amoxicillin Clavulanic Acid Tablets are best suited to treat these infections. (isconlifesciences.co.in)
Amoxicillin Clavulanic Acid tablets are chewable tablets that are preferable taking with snacks or proper meals. (isconlifesciences.co.in)

On April 1, 2020 Amoxycillin and Clavulanic Acid 125/31.25 (Apo) was not listed on the Australian Register of Therapeutic Goods (ARTG). (healthdirect.gov.au)
Can I take Amoxycillin and Clavulanic Acid 125/31.25 (Apo) in sport? (healthdirect.gov.au)

Clavulanic acid was discovered around 1974-75 by British scientists working at the drug company Beecham from the bacteria Streptomyces clavuligerus. (wikipedia.org)
Clavulanic acid therefore increases the range of bacteria that ticarcillin can kill. (netdoctor.co.uk)
Clavulanic acid enhances the effectiveness of amoxicillin against bacteria that are ordinarily resistant to amoxicillin alone. (medicinenet.com)
Administered together with amoxicillin, clavulanic acid is efficient in fighting infections caused by highly resistant gram-positive or gram-negative bacteria. (vetinfo.com)
Clavulanic acid is used to increase the effectiveness of amoxycillin against certain types of bacteria. (news-medical.net)
The administration of linezolid mainly had an impact on the gram-positive bacteria and linezolid thus had an ecological profile different from that of amoxicillin/clavulanic acid. (nih.gov)
Amoxicillin /clavulanic acid is widely used to treat or prevent many infections caused by susceptible bacteria, such as: urinary tract infections. (yahoo.com)

Abimox-CA Amoxicillin trihydrate 1000 mg, clavulanic acid 200 mg. (drugsupdate.com)

CEA synthase is a 60.9 kDA protein and is the first gene found in the clavulanic acid biosynthesis gene cluster, encoded by orf2 of the clavulanic acid gene cluster. (wikipedia.org)
Structural and biochemical studies of the orf12 gene product (ORF12) from the clavulanic acid (CA) biosynthesis gene cluster are described. (diva-portal.org)

Clinical outcomes in typhoid fevdverse impact of infection with nalidixic acid-resistant salmonella typhitamilarasu kadhiravandepartment of medicine, all india institute of medical sciences, new delhi, indiabmc infect dis. (atspace.com)
This name, unlike co-trimoxazole, has not been widely adopted internationally and the combination product is usually referred to by various names such as amoxicillin with clavulanic acid or amoxicillin+clavulanate or simply by a trade name such as EXCLAV (by NeoMedD), HECLAV-625 (by Mascot),Twinox (by USV) CLAMP (by FGP), Synermox, Augmentin (by GlaxoSmithKline formerly Beecham),Tormoxin Clav (India) or Clavamel. (drugsupdate.com)
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OBJECTIVE: To evaluate the efficacy of early empiric prescription of am amoxicillin and amoxicillin + clavulanic acid in children with reactive arthritis (ReA) when the arthritis-triggering microorganism is not identified. (prohealth.com)
There was no significant difference in the efficacy of amoxicillin and amoxicillin + clavulanic acid. (prohealth.com)
Efficacy of amoxicillin/clavulanic acid in preventing infectious and inflammatory complications following impacted mandibular third molar extraction. (biomedsearch.com)

In its most common preparations, potassium clavulanate (clavulanic acid as a salt of potassium) is combined with: amoxicillin (co-amoxiclav, trade names Augmentin, Tyclav, Clavamox (veterinary), Synulox (veterinary), and others) ticarcillin (co-ticarclav, trade name Timentin) Clavulanic acid was patented in 1974. (wikipedia.org)
Timentin injection contains two active ingredients, ticarcillin and clavulanic acid. (netdoctor.co.uk)
Ticarcillin + Clavulanic Acid is a topic covered in the Johns Hopkins ABX Guide . (hopkinsguides.com)

The article presents a case study of a 60-year-old woman who was diagnosed with symmetrical drug related intertriginous and flexural exanthema after she received amoxicillin/clavulanic acid for exacerbation of chronic bronchitis. (ebscohost.com)

Amoxycillin Clavulanic Acid Induced Hepatotoxicity. (bvsalud.org)
Patient gave history that though other drugs were given to him by his physician for fever with chills & rigors, malaise, bodyache, except amoxycillin-clavulanic acid combination all other drugs were well tolerated previously by the patient , without appearance of jaundice . (bvsalud.org)
Though severe liver injury is rare, proper history should be taken while prescribing amoxycillin-clavulanic acid combination. (bvsalud.org)

Clavulanic acid is a type of medicine known as a beta-lactamase inhibitor. (netdoctor.co.uk)
Clavulanic acid is in a class of medications called beta-lactamase inhibitors. (medlineplus.gov)
The acid is a suicide inhibitor of bacterial beta-lactamase enzymes from streptomyces clavuligerus. (biology-online.org)

The UK Committee on Safety of Medicines (CSM) recommends that treatments such as amoxicillin/clavulanic acid preparations be reserved for bacterial infections likely to be caused by amoxicillin-resistant β-lactamase-producing strains, and that treatment should not normally exceed 14 days. (wikipedia.org)
The medicines below all contain the following active ingredient(s): amoxicillin + clavulanic acid. (healthdirect.gov.au)
Do not give this medicine if your child has previously experienced liver problems after taking APO-Amoxycillin and Clavulanic Acid Suspension or any other medicines. (news-medical.net)
Some medicines and APO-Amoxycillin and Clavulanic Acid Suspension may interfere with each other. (news-medical.net)
These medicines may be affected by APO-Amoxycillin and Clavulanic Acid Suspension or may affect how well it works. (news-medical.net)
Do away use ask balance to these last medication medicines, severe if fda swallowing acid. (atspace.com)

The β-lactam like structure of clavulanic acid looks structurally similar to penicillin, but the biosynthesis of this molecule involves a different biochemical pathway. (wikipedia.org)
In addition to clavulanic acid, S. clavuligerus also produces the following other β-lactam metabolites that are structurally similar to clavulanic acid: clavam-2-carboxylate, 2-formyloxymethylclavam, 2-hydroxymethylclavam, and alanylclavam ( 10 , 42 ) (Fig. 1 ). (asm.org)

Treatment of bacterial infections caused by organisms sensitive to amoxycillin and clavulanic acid in dogs and cats. (discountpetmeds.com.au)

Differences between clavulanic acid and sulbactam in induction and inhibition of cephalosporinases in enterobacteria. (nih.gov)
The ability of clavulanic acid and sulbactam to induce and inhibit cephalosporinases was evaluated in 16 clinical isolates of enterobacteria. (nih.gov)
Using the quantitative induction assay, the checkerboard method and the disc approximation test, clavulanic acid was shown to act as inducer for all species, whereas sulbactam only induced strains of Providencia stuartii. (nih.gov)
Antagonism was achieved using a combination of clavulanic acid and cefotaxime but a combination of sulbactam and cefotaxime was either synergistic or indifferent. (nih.gov)
This variation in effect was probably due to the fact that sulbactam, but not clavulanic acid could inhibit cephalosporinases. (nih.gov)
The study will be conducted to investigate the pharmacokinetics of ampicillin / sulbactam and amoxicillin/clavulanic acid during intermittent haemodialysis. (clinicaltrials.gov)
Influence of hemodialysis on the area under concentration curve of ampicillin /sulbactam and amoxicillin / clavulanic acid plasma concentration levels. (clinicaltrials.gov)
Known hypersensitivity to ampicillin / sulbactam, amoxicillin / clavulanic acid or other beta-lactames, or severe hypersensitivity (anaphylactic reaction) to beta-lactam antibacterial agents. (clinicaltrials.gov)
Ampicillin / sulbactam respectively amoxicillin / clavulanic acid as monotherapy for resistant species or fungal infections. (clinicaltrials.gov)
Inhibitors - incouding clavulanic acid and sulbactam. (atspace.com)

The dosage of APO-Amoxycillin and Clavulanic Acid Suspension may need to be changed or your child may need to be given an alternative medicine. (news-medical.net)

Augmentin is a combination of two drugs: Amoxycillin and Clavulanic Acid. (index-china.com)
This combination is sometimes used with a stomach acid reducer called lansoprazole (Prevacid). (pharmacy-network.com)
In Vitro Study of Clavulanic Acid in Combination with Penicillin, Amoxycillin, and Carbenicillin. (toku-e.com)
Herein we report a rare case of amoxycillinclavulanic acid combination induced liver injury of cholestatic pattern in 40 years old, well educated male patient . (bvsalud.org)
So jaundice in this patient was most probably due to amoxycillinclavulanic acid combination. (bvsalud.org)
Attention must be paid to potential side-effects of the drugs and close follow-up with patients is a medical necessity to evaluate adverse reactions, especially in case of amoxycillinclavulanic acid combination. (bvsalud.org)
It may also increase the risk of yeast infections and, when used in combination with clavulanic acid, diarrhea. (wikipedia.org)

Clavulanic acid is a β-lactam drug that functions as a mechanism-based β-lactamase inhibitor. (wikipedia.org)
Clavulanic acid is a suicide inhibitor, covalently bonding to a serine residue in the active site of the β-lactamase. (wikipedia.org)
Streptomyces clavuligerus is a bacterium capable of producing a number of β-lactam metabolites, including, most notably, the β-lactamase inhibitor clavulanic acid ( 9 ). (asm.org)
For this reason, it may be combined with clavulanic acid, a β-lactamase inhibitor. (wikipedia.org)

This medicine contains the active ingredients amoxycillin (as trihydrate) and clavulanic acid (as potassium clavulanate). (news-medical.net)

The name is derived from strains of Streptomyces clavuligerus, which produces clavulanic acid. (wikipedia.org)
Clavulanic acid is produced by the bacterium Streptomyces clavuligerus, using glyceraldehyde-3-phosphate and L-arginine as starting materials. (wikipedia.org)
Streptomyces clavuligerus produces at least five different clavam metabolites, including clavulanic acid and the methionine antimetabolite, alanylclavam. (asm.org)
This gene is located in the clavulanic acid (CA) gene cluster of Streptomyces clavuligerus and is essential for CA production. (asm.org)

The 250 mg regular tablet and the 250 mg chewable tablet contain different amounts of clavulanic acid. (medlineplus.gov)
No more than one tablet should be taken at a time since the extra clavulanic acid can cause stomach upset. (medicinenet.com)
All the Amoxicillin Clavulanic Acid Tablet BP are quality guaranteed. (nouvasant.com)
We are China Origin Factory of Amoxicillin Clavulanic Acid Tablet USP. (nouvasant.com)

All of these types of proteins are normally involved in amino acid metabolism. (asm.org)
Culture media composed by cereal flours and digested proteins supply the amino acids required in the biosynthesis of clavam-related metabolites [ 2 ]. (scielo.org.co)
Electrophoresis is an important bio-separation technique widely used in molecular biology and many aspects of medicine to characterise proteins, nucleic acids and sub-cellular. (geelawsonchemical.com)

Kumar R, Qureshi S, Jakus J, Palma-Diaz MF.A severe case of acute generalized exanthematous pustulosis (AGEP) in a child after the administration of amoxicillin-clavulanic acid: brief report. (springer.com)
1 We present 3 cases of dental discoloration in children related to the administration of amoxicillin-clavulanic acid. (aappublications.org)

The only medication he received prior to presentation was amoxicillin/clavulanic acid as prophylaxis for a dental procedure with his symptoms starting on day 9th of therapy. (biomedcentral.com)

This leaflet answers some common questions about APO-Amoxycillin and Clavulanic Acid Suspension. (news-medical.net)
APO-Amoxycillin and Clavulanic Acid Suspension may affect the results of these tests. (news-medical.net)
If you have not told your doctor about any of the above, tell him/her before you give APO-Amoxycillin and Clavulanic Acid Suspension to your child. (news-medical.net)
These may interfere with the actions of APO-Amoxycillin and Clavulanic Acid Suspension. (news-medical.net)

Although clavulanic acid has only weak antimicrobial activity, it inhibits serine β-lactamase enzymes, which are responsible for much of the penicillin resistance that is seen in clinical settings. (asm.org)

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In rare cases clavulanic acid can trigger allergic reactions which manifest through: swelling, fever, breathing problems and rashes. (vetinfo.com)
After excluding allergic conditions, he was given amoxicillin/clavulanic acid intravenously. (biomedcentral.com)
Curam Duo (Amoxicillin/Clavulanic Acid) should not be used by patients who are allergic to penicillin or who have had a bad reaction to similar treatments in the past. (4nrx-uk.md)

Understanding the complete biosynthetic pathway of clavulanic acid could lead to the design of new strains of S. clavuligerus able to produce higher levels or more potent variants of clavulanic acid. (asm.org)
Proposed biosynthetic pathway leading to clavulanic acid and the 5 S clavams in S. clavuligerus . (asm.org)
However, once clavaminic acid is synthesized, the pathway splits into two branches, one specific for clavulanic acid production and the other for 5 S clavam production ( 13 ) (Fig. 1 ). (asm.org)
Two reactions from the late stages of the pathway leading to clavulanic acid have been characterized ( 2 , 21 , 35 ), while only one intermediate leading specifically to the 5 S clavams, 2-carboxymethylideneclavam, has been identified ( 51 ). (asm.org)
Cosynthesis assays using non-clavulanic acid-producing mutants showed that the addition of pure N -acetylglycyl-clavaminic acid to mutants in which clavulanic acid formation was blocked resulted in the recovery of clavulanic acid production, but only in mutants blocked in the early steps of the pathway. (asm.org)
This suggests that N -acetylglycyl-clavaminic acid is a previously unknown late intermediate of the clavulanic acid pathway. (asm.org)

Augmentin, Amoclan, Augmentin, Augmentin XR, and Augmentin ES-600 are the brand names available for amoxicillin/clavulanic in the US. (medicinenet.com)

Acids , Salts , and derivatives of Clavulanic Acid (C8H9O5N). (online-medical-dictionary.org)
chemical ) clavulanic acid (c8h9o5n) and its salts and esters . (biology-online.org)

The paralogue cluster includes one group of clavulanic acid biosynthetic genes in S. clavuligerus . (asm.org)
Mutants with defects in any of the genes orfA , orfB , orfC , or orfD were unable to produce alanylclavam but could produce all of the other clavams, including clavulanic acid. (asm.org)
The expression of the clavulanic acid genes in the oppA2 mutant is not significantly affected, but the genes for holomycin biosynthesis are strongly upregulated, in agreement with the higher holomycin production by this strain. (asm.org)

These are the clavulanic acid, the clavam, and the paralogue gene clusters. (asm.org)
Expression of the clavulanic acid, clavam, and cephamycin C biosynthesis gene clusters was not significantly affected in the oppA2 deletion mutant. (asm.org)

Clavulanic acid (CLA) exhibits low MICs against some Acinetobacter baumannii strains. (asm.org)
Strains in which oppA2 was mutated secreted into the culture the compound N -acetylglycyl-clavaminic acid (AGCA), a putative intermediate of CA biosynthesis. (asm.org)
Strains producing ampc or class b carbapenemases will not respond to clavulanic acid and will generally be cefoxitin resistant. (atspace.com)

Abimox-CA Amoxicillin trihydrate 500 mg, clavulanic acid 125 mg. (drugsupdate.com)

This restructures the clavulanic acid molecule, creating a much more reactive species that attacks another amino acid in the active site, permanently inactivating it, and thus inactivating the enzyme. (wikipedia.org)
The nucleotide and deduced amino acid sequences were analyzed and compared using blast software available online at webcite. (atspace.com)

RESULTS: After 1 month of observation no signs of disease activity were found in 48.0% of patients who were prescribed amoxicillin, in 58.5% of patients treated with amoxicillin + clavulanic acid, and only in 13.0% of patients from the control group (p (prohealth.com)
After 3 months of observation no disease activity was found in 92.0% of patients who used amoxicillin, in 95.1% of those treated with amoxicillin + clavulanic acid, and in 58.7% of children from the control group (p (prohealth.com)

Severe neutropenia during treatment with amoxicillin/clavulanic acid in a patient on regular hemodialysis treatment]. (springer.com)

article{7105645, abstract = {There is little data available to guide amoxicillin-clavulanic acid dosing in critically ill children. (ugent.be)

What side effects can occur from Amoxicillin + Clavulanic Acid? (hellodoktor.com)
What are the side effects of Curam Duo (Amoxicillin/Clavulanic acid)? (4nrx-uk.md)

Defender Amoxycillin 200 mg, clavulanic acid 28.5 mg/5 mL. (drugsupdate.com)
A-Clas Amoxicillin 200 mg, Clavulanic acid 28.5 mg. (drugsupdate.com)
AB-CV Amoxicillin 200 mg, Clavulanic acid 28.5 mg/5 mL. (drugsupdate.com)
Aca Amoxicillin 200 mg, clavulanic acid 28.5 mg. (drugsupdate.com)
Aceclav-DS Amoxicillin 200 mg, Clavulanic acid 28.5 mg/5 mL. (drugsupdate.com)
Acmox-AG Amoxycillin 200 mg, Clavulanic acid 28.5 mg. (drugsupdate.com)

Organisms12

Diseases3

Chemicals and Drugs38

Analytical, Diagnostic and Therapeutic Techniques and Equipment5

Phenomena and Processes11

Disciplines and Occupations1

Information Science1

In-vitro susceptibility of 1982 respiratory tract pathogens and 1921 urinary tract pathogens against 19 antimicrobial agents: a Canadian multicentre study. Canadian Antimicrobial Study Group. (1/262)

Once-daily, high-dose levofloxacin versus ticarcillin-clavulanate alone or followed by amoxicillin-clavulanate for complicated skin and skin-structure infections: a randomized, open-label trial. (2/262)

In vitro study of clavulanic acid in combination with penicillin, amoxycillin, and carbenicillin. (3/262)

Evaluation of ticarcillin/clavulanic acid versus ceftriaxone plus amikacin for fever and neutropenia in pediatric patients with leukemia and lymphoma. (4/262)

Susceptibilities of 540 anaerobic gram-negative bacilli to amoxicillin, amoxicillin-BRL 42715, amoxicillin-clavulanate, temafloxacin, and clindamycin. (5/262)

Characterization of the Streptomyces clavuligerus argC gene encoding N-acetylglutamyl-phosphate reductase: expression in Streptomyces lividans and effect on clavulanic acid production. (6/262)

Broth microdilution testing of Haemophilus influenzae with haemophilus test medium versus lysed horse blood broth. Canadian Haemophilus Study Group. (7/262)

Three-day intravenous triple therapy is not effective for the eradication of Helicobacter pylori infection in patients with bleeding gastro-duodenal ulcer. (8/262)

Clavulanic Acid

Clavulanic Acids

Amoxicillin-Potassium Clavulanate Combination

Ticarcillin

Amoxicillin

beta-Lactamases

Sulbactam

Penicillanic Acid

beta-Lactams

Cephamycins

Anti-Bacterial Agents

Streptomyces

Microbial Sensitivity Tests

Ureohydrolases

Penicillins

Lactams

Cephalosporinase

beta-Lactam Resistance

Penicillinase

Isoelectric Focusing

Drug Combinations

Cephalosporins

Piperacillin

Thienamycins

Ampicillin

Aztreonam

Penicillin Resistance

Klebsiella pneumoniae

Ceftazidime

Dicloxacillin

Penicillin G

Drug Therapy, Combination

Azlocillin

Enterobacteriaceae

Imipenem

Carbenicillin

Aza Compounds

Ochrobactrum anthropi

Drug Resistance, Bacterial

Klebsiella

Cloxacillin

Monobactams

Plasmids

Drug Synergism

Premedication

Bacterial Proteins

Bacteroides fragilis

Drug Resistance, Microbial

Bacterial Infections

Escherichia coli

Genes, Bacterial

Bacteria

Molecular Sequence Data

Kinetics

Ampicillin Resistance

Colorectal Surgery

Cefoxitin

Multigene Family

Cephalothin

Cephalosporin Resistance

Sulfadimethoxine

Thermotoga neapolitana

Cefuroxime

Proteus

Enzyme Inhibitors

Otitis Media, Suppurative

Cefotaxime

Enterobacter cloacae

Klebsiella oxytoca

Sequence Analysis, DNA

Bacteroides Infections

In-vitro susceptibility of 1982 respiratory tract pathogens and 1921 urinary tract pathogens against 19 antimicrobial agents: a Canadian multicentre study. Canadian Antimicrobial Study Group. (1/262)

Once-daily, high-dose levofloxacin versus ticarcillin-clavulanate alone or followed by amoxicillin-clavulanate for complicated skin and skin-structure infections: a randomized, open-label trial. (2/262)

In vitro study of clavulanic acid in combination with penicillin, amoxycillin, and carbenicillin. (3/262)

Evaluation of ticarcillin/clavulanic acid versus ceftriaxone plus amikacin for fever and neutropenia in pediatric patients with leukemia and lymphoma. (4/262)

Susceptibilities of 540 anaerobic gram-negative bacilli to amoxicillin, amoxicillin-BRL 42715, amoxicillin-clavulanate, temafloxacin, and clindamycin. (5/262)

Characterization of the Streptomyces clavuligerus argC gene encoding N-acetylglutamyl-phosphate reductase: expression in Streptomyces lividans and effect on clavulanic acid production. (6/262)

Broth microdilution testing of Haemophilus influenzae with haemophilus test medium versus lysed horse blood broth. Canadian Haemophilus Study Group. (7/262)

Three-day intravenous triple therapy is not effective for the eradication of Helicobacter pylori infection in patients with bleeding gastro-duodenal ulcer. (8/262)

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