Clavulanic acid and its salts and esters. The acid is a suicide inhibitor of bacterial beta-lactamase enzymes from Streptomyces clavuligerus. Administered alone, it has only weak antibacterial activity against most organisms, but given in combination with other beta-lactam antibiotics it prevents antibiotic inactivation by microbial lactamase.
Acids, salts, and derivatives of clavulanic acid (C8H9O5N). They consist of those beta-lactam compounds that differ from penicillin in having the sulfur of the thiazolidine ring replaced by an oxygen. They have limited antibacterial action, but block bacterial beta-lactamase irreversibly, so that similar antibiotics are not broken down by the bacterial enzymes and therefore can exert their antibacterial effects.
A fixed-ratio combination of amoxicillin trihydrate and potassium clavulanate.
An antibiotic derived from penicillin similar to CARBENICILLIN in action.
A broad-spectrum semisynthetic antibiotic similar to AMPICILLIN except that its resistance to gastric acid permits higher serum levels with oral administration.
Enzymes found in many bacteria which catalyze the hydrolysis of the amide bond in the beta-lactam ring. Well known antibiotics destroyed by these enzymes are penicillins and cephalosporins.
A beta-lactamase inhibitor with very weak antibacterial action. The compound prevents antibiotic destruction of beta-lactam antibiotics by inhibiting beta-lactamases, thus extending their spectrum activity. Combinations of sulbactam with beta-lactam antibiotics have been used successfully for the therapy of infections caused by organisms resistant to the antibiotic alone.
A building block of penicillin, devoid of significant antibacterial activity. (From Merck Index, 11th ed)
Four-membered cyclic AMIDES, best known for the PENICILLINS based on a bicyclo-thiazolidine, as well as the CEPHALOSPORINS based on a bicyclo-thiazine, and including monocyclic MONOBACTAMS. The BETA-LACTAMASES hydrolyze the beta lactam ring, accounting for BETA-LACTAM RESISTANCE of infective bacteria.
Naturally occurring family of beta-lactam cephalosporin-type antibiotics having a 7-methoxy group and possessing marked resistance to the action of beta-lactamases from gram-positive and gram-negative organisms.
Substances that reduce the growth or reproduction of BACTERIA.
A genus of bacteria that form a nonfragmented aerial mycelium. Many species have been identified with some being pathogenic. This genus is responsible for producing a majority of the ANTI-BACTERIAL AGENTS of practical value.
Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).
A group of antibiotics that contain 6-aminopenicillanic acid with a side chain attached to the 6-amino group. The penicillin nucleus is the chief structural requirement for biological activity. The side-chain structure determines many of the antibacterial and pharmacological characteristics. (Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1065)
Cyclic AMIDES formed from aminocarboxylic acids by the elimination of water. Lactims are the enol forms of lactams.
Nonsusceptibility of bacteria to the action of the beta-lactam antibiotics. Mechanisms responsible for beta-lactam resistance may be degradation of antibiotics by BETA-LACTAMASES, failure of antibiotics to penetrate, or low-affinity binding of antibiotics to targets.
A beta-lactamase preferentially cleaving penicillins. (Dorland, 28th ed) EC 3.5.2.-.
Electrophoresis in which a pH gradient is established in a gel medium and proteins migrate until they reach the site (or focus) at which the pH is equal to their isoelectric point.
Single preparations containing two or more active agents, for the purpose of their concurrent administration as a fixed dose mixture.
A group of broad-spectrum antibiotics first isolated from the Mediterranean fungus ACREMONIUM. They contain the beta-lactam moiety thia-azabicyclo-octenecarboxylic acid also called 7-aminocephalosporanic acid.
Semisynthetic, broad-spectrum, AMPICILLIN derived ureidopenicillin antibiotic proposed for PSEUDOMONAS infections. It is also used in combination with other antibiotics.
Beta-lactam antibiotics that differ from PENICILLINS in having the thiazolidine sulfur atom replaced by carbon, the sulfur then becoming the first atom in the side chain. They are unstable chemically, but have a very broad antibacterial spectrum. Thienamycin and its more stable derivatives are proposed for use in combinations with enzyme inhibitors.
Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.
A monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum. It is resistant to beta-lactamases and is used in gram-negative infections, especially of the meninges, bladder, and kidneys. It may cause a superinfection with gram-positive organisms.
Nonsusceptibility of an organism to the action of penicillins.
Gram-negative, non-motile, capsulated, gas-producing rods found widely in nature and associated with urinary and respiratory infections in humans.
Semisynthetic, broad-spectrum antibacterial derived from CEPHALORIDINE and used especially for Pseudomonas and other gram-negative infections in debilitated patients.
One of the PENICILLINS which is resistant to PENICILLINASE.
A penicillin derivative commonly used in the form of its sodium or potassium salts in the treatment of a variety of infections. It is effective against most gram-positive bacteria and against gram-negative cocci. It has also been used as an experimental convulsant because of its actions on GAMMA-AMINOBUTYRIC ACID mediated synaptic transmission.
Therapy with two or more separate preparations given for a combined effect.
A semisynthetic ampicillin-derived acylureido penicillin.
A family of gram-negative, facultatively anaerobic, rod-shaped bacteria that do not form endospores. Its organisms are distributed worldwide with some being saprophytes and others being plant and animal parasites. Many species are of considerable economic importance due to their pathogenic effects on agriculture and livestock.
Semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains. It is stable to beta-lactamases. Clinical studies have demonstrated high efficacy in the treatment of infections of various body systems. Its effectiveness is enhanced when it is administered in combination with CILASTATIN, a renal dipeptidase inhibitor.
Broad-spectrum semisynthetic penicillin derivative used parenterally. It is susceptible to gastric juice and penicillinase and may damage platelet function.
A species of gram-negative, obligately aerobic rods. Motility occurs by peritrichous flagella. (From Bergey's Manual of Determinative Bacteriology, 9th ed)
The ability of bacteria to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).
A genus of gram-negative, facultatively anaerobic, rod-shaped bacteria whose organisms arrange singly, in pairs, or short chains. This genus is commonly found in the intestinal tract and is an opportunistic pathogen that can give rise to bacteremia, pneumonia, urinary tract and several other types of human infection.
A semi-synthetic antibiotic that is a chlorinated derivative of OXACILLIN.
Monocyclic, bacterially produced or semisynthetic beta-lactam antibiotics. They lack the double ring construction of the traditional beta-lactam antibiotics and can be easily synthesized.
Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.
The action of a drug in promoting or enhancing the effectiveness of another drug.
Preliminary administration of a drug preceding a diagnostic, therapeutic, or surgical procedure. The commonest types of premedication are antibiotics (ANTIBIOTIC PROPHYLAXIS) and anti-anxiety agents. It does not include PREANESTHETIC MEDICATION.
Proteins found in any species of bacterium.
Gram-negative bacteria occurring in the lower intestinal tracts of man and other animals. It is the most common species of anaerobic bacteria isolated from human soft tissue infections.
The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).
Infections by bacteria, general or unspecified.
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
The functional hereditary units of BACTERIA.
One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The rate dynamics in chemical or physical systems.
Nonsusceptibility of a microbe to the action of ampicillin, a penicillin derivative that interferes with cell wall synthesis.
A surgical specialty concerned with the diagnosis and treatment of disorders and abnormalities of the COLON; RECTUM; and ANAL CANAL.
A semisynthetic cephamycin antibiotic resistant to beta-lactamase.
A set of genes descended by duplication and variation from some ancestral gene. Such genes may be clustered together on the same chromosome or dispersed on different chromosomes. Examples of multigene families include those that encode the hemoglobins, immunoglobulins, histocompatibility antigens, actins, tubulins, keratins, collagens, heat shock proteins, salivary glue proteins, chorion proteins, cuticle proteins, yolk proteins, and phaseolins, as well as histones, ribosomal RNA, and transfer RNA genes. The latter three are examples of reiterated genes, where hundreds of identical genes are present in a tandem array. (King & Stanfield, A Dictionary of Genetics, 4th ed)
A cephalosporin antibiotic.
Non-susceptibility of an organism to the action of the cephalosporins.
A sulfanilamide that is used as an anti-infective agent.
A species of extremophilic bacteria in the family Thermotogaceae. Generally anaerobic but in the presence of OXYGEN, it can produce hydrogen gas as a byproduct of metabolism.
Broad-spectrum cephalosporin antibiotic resistant to beta-lactamase. It has been proposed for infections with gram-negative and gram-positive organisms, GONORRHEA, and HAEMOPHILUS.
A genus of gram-negative, facultatively anaerobic, rod-shaped bacteria that occurs in the intestines of humans and a wide variety of animals, as well as in manure, soil, and polluted waters. Its species are pathogenic, causing urinary tract infections and are also considered secondary invaders, causing septic lesions at other sites of the body.
Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
Inflammation of the middle ear with purulent discharge.
Semisynthetic broad-spectrum cephalosporin.
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria that occurs in water, sewage, soil, meat, hospital environments, and on the skin and in the intestinal tract of man and animals as a commensal.
A species of gram-negative bacteria causing URINARY TRACT INFECTIONS and SEPTICEMIA.
A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.
Infections with bacteria of the genus BACTEROIDES.

In-vitro susceptibility of 1982 respiratory tract pathogens and 1921 urinary tract pathogens against 19 antimicrobial agents: a Canadian multicentre study. Canadian Antimicrobial Study Group. (1/262)

A total of 3903 pathogens from 48 Canadian medical centres were tested against 19 antimicrobial agents. Five agents showed activity against > or = 90% of all 1982 respiratory tract pathogens tested (ciprofloxacin, 90%; cefoperazone, 91%; ticarcillin/clavulanate, 92%; ceftazidime and imipenem, 93% each). Nine agents had > or = 90% activity against Enterobacteriaceae from respiratory tract infection (cefotaxime and ticarcillin/clavulanate, 90% each; aztreonam, ceftizoxime and ceftriaxone, 91% each; ceftazidime, 93%; ciprofloxacin, 97%; imipenem and netilmicin, 98% each). Similarly, five agents had activity against > or = 90% of all 1921 urinary tract pathogens tested (ciprofloxacin and ticarcillin/clavulanate, 90% each; cefoperazone and netilmicin, 91% each; imipenem, 99%). Nine agents had > or = 95% activity against Enterobacteriaceae from urinary tract infection (ciprofloxacin, 95%; cefotetan, 97%; aztreonam, cefotaxime, ceftazidime, ceftizoxime, ceftriaxone and netilmicin, 98% each; imipenem, 99%). Seventeen agents had activity against > or = 95% of Staphylococcus aureus strains. Susceptibility of Pseudomonas aeruginosa isolates ranged from 2% to 91%.  (+info)

Once-daily, high-dose levofloxacin versus ticarcillin-clavulanate alone or followed by amoxicillin-clavulanate for complicated skin and skin-structure infections: a randomized, open-label trial. (2/262)

This study tested whether levofloxacin, at a new high dose of 750 mg, was effective for the treatment of complicated skin and skin-structure infections (SSSIs). Patients with complicated SSSIs (n=399) were randomly assigned in a ratio of 1:1 to 2 treatment arms: levofloxacin (750 mg given once per day intravenously [iv], orally, or iv/orally) or ticarcillin-clavulanate (TC; 3.1 g given iv every 4-6 hours) followed, at the investigator's discretion, by amoxicillin-clavulanate (AC; 875 mg given orally every 12 hours). In the clinically evaluable population, therapeutic equivalence was demonstrated between the levofloxacin and TC/AC regimens (success rates of 84.1% and 80.3%, respectively). In the microbiologically evaluable population, the overall rate of eradication was 83.7% in the levofloxacin treatment group and 71.4% in the TC/AC treatment group (95% confidence interval, -24.3 to -0.2). Both levofloxacin and TC/AC were well tolerated. These data demonstrate that levofloxacin (750 mg once per day) is safe and at least as effective as TC/AC for complicated SSSIs.  (+info)

In vitro study of clavulanic acid in combination with penicillin, amoxycillin, and carbenicillin. (3/262)

The activity of clavulanic acid alone and in combination with penicillin, amoxycillin, and carbenicillin was studied. Marked reductions in the minimum inhibitory concentrations (MICs) for a wide spectrum of beta-lactamase-producing clinical isolates were found. Of particular interest were the decreased MICs of penicillin for Bacteroides fragilis and beta-lactamase-producing strains of Neisseria gonorrhoea in the presence of the clavulanic acid. Beta-lactamase-producing strains of Escherichia coli, Klebsiella spp., and indole-negative Proteus also showed considerably increased susceptibility to amoxycillin in combination with clavulanic acid. Two beta-lactamase-producing strains of Pseudomonas aeruginosa remained resistant to carbenicillin in the presence of clavulanic acid.  (+info)

Evaluation of ticarcillin/clavulanic acid versus ceftriaxone plus amikacin for fever and neutropenia in pediatric patients with leukemia and lymphoma. (4/262)

BACKGROUND: The empirical use of antibiotic treatments is widely accepted as a means to treat cancer patients in chemotherapy who have fever and neutropenia. Intravenous monotherapy, with broad spectrum antibiotics, of patients with a high risk of complications is a possible alternative. METHODS: We conducted a prospective open-label, randomized study of patients with lymphoma or leukemia who had fever and neutropenia during chemotherapy. Patients received either monotherapy with ticarcillin/clavulanic acid (T) or ceftriaxone plus amikacin (C+A). RESULTS: Seventy patients who presented 136 episodes were evaluated, 68 in each arm of the study. The mean neutrophil counts at admission were 217cells/mm(3) (T) and 201cells/mm(3) (C+A). The mean duration of neutropenia was 8.7 days (T) and 7.6 days (C+A). Treatment was successful without the need for modifications in 71% of the episodes in the T group and 81% in the C+A group (p=0.23). Treatment was considered to have failed because of death in two episodes (3%) in the T group and three episodes (4%) in the C+A group, and because of a change in the drug applied in one episode in the T group and two episodes in the C+A group. Overall success was 96% (T) and 93% (C+A). Adverse events that occurred in group T were not related to the drugs used in this study. CONCLUSION: In pediatric and adolescent patients with leukemia or lymphoma, who presented with fever and neutropenia, during chemotherapy, ticarcillin/clavulanic acid was as successful as the combination of ceftriaxone plus amikacin. It should be considered an appropriate option for this group of patients at high risk for infections.  (+info)

Susceptibilities of 540 anaerobic gram-negative bacilli to amoxicillin, amoxicillin-BRL 42715, amoxicillin-clavulanate, temafloxacin, and clindamycin. (5/262)

Agar dilution MIC testing of amoxicillin, amoxicillin-BRL 42715, amoxicillin-clavulanate, temafloxacin, and clindamycin against 496 beta-lactamase-producing anaerobic gram-negative rods revealed MICs for 90% of the strains tested of 256.0 (amoxicillin), 2.0 (amoxicillin-BRL 42715 and amoxicillin-clavulanate), and 4.0 (temafloxacin and clindamycin) microgram/ml. Amoxicillin, temafloxacin, and clindamycin inhibited all 44 beta-lactamase-negative strains (MICs for 90% of the strains tested, less than or equal to 2.0 micrograms/ml). BRL 42715 will not be developed, but temafloxacin merits clinical evaluation.  (+info)

Characterization of the Streptomyces clavuligerus argC gene encoding N-acetylglutamyl-phosphate reductase: expression in Streptomyces lividans and effect on clavulanic acid production. (6/262)

The argC gene of Streptomyces clavuligerus encoding N-acetylglutamyl-phosphate reductase (AGPR) has been cloned by complementation of argC mutants Streptomyces lividans 1674 and Escherichia coli XC33. The gene is contained in an open reading frame of 1,023 nucleotides which encodes a protein of 340 amino acids with a deduced molecular mass of 35,224 Da. The argC gene is linked to argE, as shown by complementation of argE mutants of E. coli. Expression of argC from cloned DNA fragments carrying the gene leads to high levels of AGPR in wild-type S. lividans and in the argC mutant S. lividans 1674. Formation of AGPR is repressed by addition of arginine to the culture medium. The protein encoded by the argC gene is very similar to the AGPRs of Streptomyces coelicolor, Bacillus subtilis, and E. coli and, to a lesser degree, to the homologous enzymes of Saccharomyces cerevisiae and Anabaena spp. A conserved PGCYPT domain present in all the AGPR sequences suggests that this may be the active center of the protein. Transformation of S. clavuligerus 328, an argC auxotroph deficient in clavulanic acid biosynthesis, with plasmid pULML30, carrying the cloned argC gene, restored both prototrophy and antibiotic production.  (+info)

Broth microdilution testing of Haemophilus influenzae with haemophilus test medium versus lysed horse blood broth. Canadian Haemophilus Study Group. (7/262)

Broth microdilution testing of 702 community-acquired isolates of Haemophilus influenzae from across Canada was performed with both Mueller-Hinton broth supplemented with 3% lysed horse blood broth (LHB) (BBL Microbiology Systems, Cockeysville, Md.) and haemophilus test medium (HTM). The prevalence of beta-lactamase production was found to be 26% with no regional variation. MICs determined with LHB tended to be higher than those with HTM, but interpretive errors due to these differences were observed only rarely with trimethoprim-sulfamethoxazole (n = 5), cefaclor (n = 8), and cefamandole (n = 3). The interobserver variability in MIC determinations was found to be greater when LHB was used than when HTM was used. There was no difference in intraobserver variability between the two medium formulations. beta-Lactamase-positive isolates developed false resistance to amoxicillin-clavulanate 2 weeks after microdilution panels of both types of medium were stored at -20 degrees C but not when panels were stored at -70 degrees C. In conclusion, this study supports the use of HTM rather than LHB for sensitivity testing of H. influenzae because of its lower rate of interobserver variability and its ability to support the growth of these organisms, which is comparable to that of LHB.  (+info)

Three-day intravenous triple therapy is not effective for the eradication of Helicobacter pylori infection in patients with bleeding gastro-duodenal ulcer. (8/262)

AIM: To test the efficacy of an ultra-short intravenous triple therapy against Helicobacter pylori infection in patients with bleeding peptic ulcer against standard oral 1-week triple therapy in a randomised, double-blind prospective trial. METHODS: PATIENTS: (n = 75) with haemorrhagic peptic ulcer and H. pylori infection were randomised into: an Intravenous Group to receive omeprazole, clarithromycin and amoxicillin-clavulanic acid intravenously b.d. for 3 days followed by 7 days of oral omeprazole plus placebo of clarithromycin and amoxicillin; an Oral Group to receive intravenous omeprazole plus placebo of clarithromycin and amoxicillin-clavulanic acid followed by 7 days of oral omeprazole, clarithromycin and amoxicillin b.d. Gastric biopsies were obtained for urease test. A 13C-urea breath test was performed to check for H. pylori eradication. RESULTS: Intention-to-treat eradication was 50% (19/38) in the Intravenous Group and 78% (29/37) in the Oral Group (odds ratio 3.63; 95% confidence interval 1.32-9.94; P < 0.01; number needed to treat (NNT) = 4). Per protocol eradication was 50% (14/28) in the Intravenous Group and 86% (24/28) in the Oral Group (P < 0.005). There were no statistically significant differences in adverse events between the two treatment groups. CONCLUSIONS: An ultra-short, 3-day, intravenous, triple therapy containing omeprazole, clarithromycin and amoxicillin-clavulanic acid cannot be recommended as an effective eradication regimen for H. pylori infection related to haemorrhagic gastro-duodenal ulcer.  (+info)

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TY - JOUR. T1 - Amoxicillin-clavulanic acid versus cefotaxime in the therapy of bacterial infections in cirrhotic patients. AU - Ricart, Elena. AU - Soriano, Germán. AU - Novella, Maria Teresa. AU - Ortiz, Jordi. AU - Sàbat, Míriam. AU - Kolle, Lylian. AU - Sola-Vera, Javier. AU - Miñana, Josep. AU - Dedéu, Josep Maria. AU - Gómez, Cristina. AU - Barrio, José L.. AU - Guarner, Carlos. PY - 2000/1/1. Y1 - 2000/1/1. N2 - Background/Aim: Cefotaxime is considered the first-choice antibiotic for empirical treatment in cirrhotic patients developing bacterial infections. It has been suggested that amoxicillin-clavulanic acid could be an alternative to cefotaxime, particularly in patients developing bacterial infections while on prophylactic norfloxacin. The aim of the present study was to compare amoxicillin-clavulanic acid with cefotaxime in the treatment of bacterial infections in cirrhosis. Methods: Ninety-six hospitalized cirrhotic patients with suspicion of bacterial infection were ...
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Structural and biochemical studies of the orf12 gene product (ORF12) from the clavulanic acid (CA) biosynthesis gene cluster are described. Sequence and crystallographic analyses reveal two domains: a C-terminal penicillin-binding protein (PBP)/beta-lactamase-type fold with highest structural similarity to the class A beta-lactamases fused to an N-terminal domain with a fold similar to steroid isomerases and polyketide cyclases. The C-terminal domain of ORF12 did not show beta-lactamase or PBP activity for the substrates tested, but did show low-level esterase activity towards 3-O-acetyl cephalosporins and a thioester substrate. Mutagenesis studies imply that Ser173, which is present in a conserved SXXK motif, acts as a nucleophile in catalysis, consistent with studies of related esterases, beta-lactamases and d-Ala carboxypeptidases. Structures of wild-type ORF12 and of catalytic residue variants were obtained in complex with and in the absence of clavulanic acid. The role of ORF12 in ...
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A process for the isolation of clavulanic acid and pharmaceutically acceptable salts thereof, such as potassium clavulanate, from the aqueous fermentation broth of a clavulanic acid-producing microorganism comprises the microfiltration of the broth without prior treatment.
TY - JOUR. T1 - Fundamental and clinical studies on BRL 25000 (clavulanic acid-amoxicillin) granules in the pediatric field. AU - Sato, Y.. AU - Iwata, S.. AU - Akita, H.. PY - 1985. Y1 - 1985. N2 - Fundamental and clinical studies have been performed on BRL 25000 (clavulanic acid 1 part-amoxicillin 2 parts) granules in the pediatric field. The antibacterical activities of BRL 25000 and amoxicillin (AMPC) were investigated against clinically isolated and laboratory stocked strains. BRL 25000 was superior to AMPC against strains of E. coli, Salmonella sp. and Klebsiella sp., and similar against Gram-positive cocci. Serum concentrations of AMPC and clavulanic acid (CVA) were measured 0.25, 0.5, 1, 2, 4 and 6 hours after administration of BRL 25000 granules at dose levels 7.5, 10, 15 and 20 mg/kg. At 7.5 mg/kg peak level of AMPC of 2.69 μg/ml was achieved about 2 hours after dosing with a biological half-life of 1.64 hours; the corresponding value for CVA was 0.53 μg/ml at 1 hour with a T 1/2 of ...
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This enzyme participates in clavulanic acid biosynthesis. Salowe SP, Krol WJ, Iwata-Reuyl D, Townsend CA (1991). "Elucidation ... Townsend CA (2002). "New reactions in clavulanic acid biosynthesis". Curr. Opin. Chem. Biol. 6 (5): 583-9. doi:10.1016/S1367- ... of the gene encoding proclavaminate amidino hydrolase and characterization of protein function in clavulanic acid biosynthesis ...
Townsend CA (October 2002). "New reactions in clavulanic acid biosynthesis". Current Opinion in Chemical Biology. 6 (5): 583-9 ... Clavaminate synthase (EC 1.14.11.21, clavaminate synthase 2, clavaminic acid synthase) is an enzyme with systematic name ... "Structural origins of the selectivity of the trifunctional oxygenase clavaminic acid synthase". Nature Structural Biology. 7 (2 ...
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Proclavaminate amidinohydrolase is involved in clavulanic acid biosynthesis. Clavulanic acid acts as an inhibitor of a wide ... evolution of a hydrolytic enzyme in clavulanic acid biosynthesis". Biochem. J. 366 (Pt 2): 423-434. doi:10.1042/BJ20020125. PMC ... Clifton IJ, Elkins JM, Hernandez H (2002). "Oligomeric structure of proclavaminic acid amidino hydrolase: ...
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Baggaley K, Brown A, Schofield C (1997). "Chemistry and biosynthesis of clavulanic acid and other clavams". Nat Prod Rep. 14 (4 ... Tahlan K, Anders C, Jensen S (2004). "The Paralogous Pairs of Genes Involved in Clavulanic Acid and Clavam Metabolite ... Streptomyces clavuligerus is a species of Gram-positive bacterium notable for producing clavulanic acid. S. clavuligerus ATCC ... Kirk S (2000). "The physiology of clavulanic acid production by Streptomyces clavuligerus (PhD thesis)". University of Surrey, ...
"APO-Amoxycillin and Clavulanic Acid 500mg/125 mg Tablets" (PDF). Retrieved November 27, 2014. Mechanism of Action of Bacitracin ... Piperacillin/tazobactam Ticarcillin/clavulanic acid Certain carbapenems and carbapenem-beta-lactamase-inhibitors combinations: ... "Amoxicillin-sulbactam versus amoxicillin-clavulanic acid for the treatment of non-recurrent-acute otitis media in Argentinean ... Clindamycin Dalbavancin Fusidic acid Mupirocin (topical) Omadacycline Oritavancin Tedizolid Telavancin Tigecycline (also covers ...
Cephalosporins, amoxicillin/clavulanic acid, or a fluoroquinolone may also be used. However, antibiotic resistance to ...
An example is clavulanic acid, from which this compound class receives its name. Clavulanic acid, a type of Clavam, has ... This class is divided into the clavulanic acid class and the 5S clavams class. Clavulanic acid is a broad-spectrum antibiotic ... Clavulanic acid strongly inhibits b-lactamase in bacteria, which is associated with its antibiotic properties. B - lactam ... This is essential for the cephamycin C and clavulanic acid but not the 5S claims. CcaR is important for the expression of ...
Amoxicillin and amoxicillin/clavulanic acid were the most frequently consumed. Antibiotics are screened for any negative ... For example, β-lactam antibiotics may be used in combination with β-lactamase inhibitors, such as clavulanic acid or sulbactam ... Methicillin-resistant Staphylococcus aureus infections may be treated with a combination therapy of fusidic acid and rifampicin ... and Amino Acids)". Applied Microbiology. Springer India. pp. 83-120. doi:10.1007/978-81-322-2259-0. ISBN 978-81-322-2258-3. ...
A strain isolated from mangroves has been demonstrated to produce clavulanic acid and streptomycin. The genome of M. ... v t e (Articles with short description, Short description matches Wikidata, Articles with 'species' microformats, Acid-fast ...
"X-ray crystal structure of ornithine acetyltransferase from the clavulanic acid biosynthesis gene cluster". Biochem. J. 385 (Pt ...
It can be sold and used in combination with clavulanate as ticarcillin/clavulanic acid. Because it is a penicillin, it also ... Ticarcillin is also often paired with a β-lactamase inhibitor such as clavulanic acid (co-ticarclav). In molecular biology, ... One synthesis began by making the monobenzyl ester of 3-Thienylmalonic acid, converting this to the acid chloride with SOCl2, ... and condensing it with 6-Aminopenicillanic acid (6-APA). Hydrogenolysis (Pd/C) completed the synthesis of ticarcillin. Fischer ...
However, HugA does not affect cephamycins or carbapenems and is inhibited by clavulanic acid. Similar to other Proteus species ... penneri LPS are the amide of D-galacturonic acid with L-lysine α-D-GalA-(L-Lys) (and the amide of D-galacturonic acid with L- ... penneri from the experiment were found to be multiple drug-resistant including resistance to amoxy-clavulanic acid combination ...
These include ampicillin, chloramphenicol, amoxicillin-clavulanic acid, cefamandole, cefuroxime, cefotaxime, tetracycline, ... "Deoxyribonucleic acid relatedness between Haemophilus aegyptius and Haemophilus influenzae," Elsevier, 137B (1986): 155-163. ...
Bacterial adenoiditis may be treated with antibiotics, such as amoxicillin - clavulanic acid or a cephalosporin. In case of ...
For example, the BAN Co-amoxiclav is assigned to preparations containing amoxicillin and clavulanic acid. Most other ... "amoxicillin with clavulanic acid". The prefix of "co-" is used for many combination drugs, including opioid with paracetamol or ...
Brown AG (August 1986). "Clavulanic acid, a novel beta-lactamase inhibitor--a case study in drug discovery and development". ...
"Simultaneous determination of amoxicillin and clavulanic acid in human plasma by HPLC-ESI mass spectrometry". Journal of ...
Mennink-Kersten MA, Warris A, Verweij PE (2006). "1,3-β-D-Glucan in patients receiving intravenous amoxicillin-clavulanic acid ... increasing fecal bulk and producing short-chain fatty acids as byproducts with wide-ranging physiological activities. This ...
Each disk is labelled with the antibiotic it contains (e.g. AMC30, 30µg amoxicillin/clavulanic acid) Antibiotic sensitivity ...
Thus imipenem/cilastatin, like amoxicillin/clavulanic acid, is a commonly used combination product. Keynan S, Hooper NM, Felici ...
In case of systemic infection, other bactericidal antibiotics are used, such as ampicillin, amoxicillin/clavulanic acid, or ... Campylobacter is sensitive to the stomach's normal production of hydrochloric acid: as a result, the infectious dose is ... since this type of medication neutralizes normal gastric acid. In humans, the sites of tissue injury include the jejunum, the ...
The first choice is amoxicillin with clavulanic acid, and if the person is penicillin-allergic, doxycycline and metronidazole. ...
Amoxicillin/clavulanic acid increases the risk of fetal bowel death (necrotizing enterocolitis) and should be avoided in ...
... amoxicillin-clavulanic acid, and cefazolin. Since these bacteria are not as harmful or virulent to the host, antibiotics should ...
Spratt BG, Jobanputra V, Zimmermann W (1977). "Binding of Thienamycin and Clavulanic Acid to the Penicillin-Binding Proteins of ... and l-α-aminoadipic acid by ACV synthetase (ACVS, a nonribosomal peptide synthetase) and then cyclization of this formed ...
Ticarcillin (often used in combination with clavulanic acid under the designation timentin), amikacin sulfate, penicillin, and ...
... mild low-risk cases may be treated with a combination of oral amoxicillin-clavulanic acid and ciprofloxacin, while more severe ... or piperacillin/tazobactam for high-risk patients and amoxicillin-clavulanic acid and ciprofloxacin for low-risk patients. ...
... the IDSA recommends treatment with cefuroxime or amoxicillin/clavulanic acid, as these are effective against both infections. ... The spirochetes may also induce host cells to secrete quinolinic acid, which stimulates the NMDA receptor on nerve cells, which ... a derivative of amino acid beta-alanine), oil of lemon eucalyptus (OLE, a natural compound) and OLE's active ingredient para- ...
These medications include: Amoxicillin (excluding Amoxicillin/clavulanic acid) Ampicillin Penicillin VK and Sulfamethoxazole- ...
Due to its clavulanic acid component, penicillin amoxicillin-clavulanate is the most common culprit of cholestatic liver injury ... The primary bile acids cholic acid (CA) and chenodeoxycholic acid (CDCA) are synthesized in the liver and undergo conjugation ... a bile acid analogue), simtuzumab (a monoclonal antibody), and 24-norursodeoxycholic acid (a synthetic bile acid). Although the ... In the treatment of ICP, current evidence suggests ursodeoxycholic acid (UDCA), a minor secondary bile acid in humans, is the ...
... clavulanic acid, which is sometimes combined with penicillin derivatives) or false negative (gentamicin, cefalexin, glycosuria ...
Antibiotics such as streptomycin, amikacin, tetracycline, doxycycline, carbapenems, ceftazidime, amoxicillin/clavulanic acid, ... neutralize the negative charge of the phosphate groups necessary for the interaction with the positively charged amino acids of ...
Penicillin and penicillin-derived antibiotics can thus be combined with a beta-lactamase inhibitor such as clavulanic acid or ...
It is susceptible to lysostaphin, furazolidone, ampicillin, amoxicillin, amoxicillin/clavulanic acid, ceftiofur, cephalexin, ... Acid production from D-arabitol, sorbitol, turanose and xylitol is variable; the type strain is positive. It is resistant to ... Acid is not formed aerobically from D-raffinose, ribose, D-cellobiose, D-arabinose, L-xylose, adonitol, methyl-D-xyloside, ... It produces acid aerobically from D-glucose, D-fructose, D-mannose, maltose, lactose, trehalose, mannitol, sucrose, L-arabinose ...
Amoxicillin/clavulanic acid, which includes the beta lactam amoxicillin with the suicide inhibitor clauvanic acid, which helps ... Amoxicillin/clavulanic acid, which includes the beta lactam amoxicillin with the suicide inhibitor clauvanic acid, which helps ...
... ceftibuten and amoxicillin/clavulanic acid) or with short courses (2 to 4 days) of intravenous therapy followed by oral therapy ... A DMSA scan is a radionuclide scan that uses dimercaptosuccinic acid in assessing the kidney morphology. It is now[when?] the ... Goldraich NP, Goldraich IH (April 1995). "Update on dimercaptosuccinic acid renal scanning in children with urinary tract ...
Vulgamycin Clavulanic acid (from S. clavuligerus) is a drug used in combination with some antibiotics (like amoxicillin) to ... Acidophilic and acid-tolerant strains that were initially classified under this genus have later been moved to Kitasatospora ( ... Nucleic Acids Research. 15 (19): 8041-56. doi:10.1093/nar/15.19.8041. PMC 306325. PMID 3118332. Nelson M, Greenwald RA, Hillen ...
Pertaining to trials of what became known as Augmentin, a combination of amoxicillin and clavulanic acid, he later recalled ... "getting the right dose of amoxicillin proved important for efficacy and getting the right dose of clavulanic acid was key to ...
In a 2004 open-label study, it was as effective as ampicillin/sulbactam and amoxicillin/clavulanic acid, and far superior in ... Lactic acidosis, a potentially life-threatening buildup of lactic acid in the body, may also occur due to mitochondrial ... Reddy's and reported in 1999, and a route starting from (S)-glyceraldehyde acetonide (prepared from ascorbic acid), developed ...
... and Clavulanic acid combination MONOTAX O (Cefpodoxime)/ MONOTAX CV (Cefpodoxime and Clavulanic acid combination) ( ... "Cefpodoxime, Free Acid Susceptibility and Minimum Inhibitory Concentration (MIC) Data" (PDF). "Pharmaceuticals Manufacturer, ...
Moxifloxacin Pyrazinamide Rifabutin Rifampicin Rifapentine Amikacinα Amoxicillin/clavulanic acid (amoxicillin + clavulanic acid ... Ferrous salt Ferrous salt/folic acid (ferrous salt + folic acid) Folic acid Hydroxocobalamin Erythropoiesis-stimulating agentsα ... clavulanic acid) Ampicillin Benzathine benzylpenicillin Benzylpenicillin Cefalexin Cefazolin Chloramphenicol Clindamycin ... Triclabendazole Oxamniquineα Albendazoleα Mebendazoleα Praziquantelα Amikacin Amoxicillin Amoxicillin/clavulanic acid ( ...
"Early Bactericidal Activity of Amoxicillin in Combination with Clavulanic Acid in Patients with Sputum Smear-positive Pulmonary ... Amino acid replacements in the NADH binding site of InhA apparently result in INH resistance by preventing the inhibition of ... Mutation in the rpoB gene changes the sequence of amino acids and eventual conformation of the beta subunit. In this case ... p-aminosalicylic acid) For patients with RR-TB or MDR-TB, "not previously treated with second-line drugs and in whom resistance ...
Amoxicillin and Clavulanic Acid: learn about side effects, dosage, special precautions, and more on MedlinePlus ... The 250 mg and 500 mg tablets of amoxicillin and clavulanic acid contain the same amount of clavulanic acid. Do not substitute ... clavulanic acid, penicillin, cephalosporins, any other medications, or any of the ingredients in amoxicillin and clavulanic ... Take amoxicillin and clavulanic acid exactly as directed. Do not take more or less of it or take it more often than prescribed ...
On this page about Amoxicillin Clavulanic Acid 500/125 (Mylan) you will find information relating to side effects, age ... Brand name: Amoxicillin Clavulanic Acid 500/125 (Mylan) TM. Active ingredients: amoxicillin + clavulanic acid ... Amoxicillin Clavulanic Acid Mylan 500 /125 and Amoxicillin Clavulanic Acid Mylan 875/125 tablets are indicated for short term ... Other medicines containing the same active ingredients: amoxicillin + clavulanic acid *Can I take Amoxicillin Clavulanic Acid ...
Clavulanic acid helps make the amoxicillin more effective. This medication is most commonly used to treat infections of the ... This combination product containing amoxicillin and clavulanic acid belongs to the group of medications known as antibiotics. ... Teva-Amoxicillin Clavulanic Acid is no longer being manufactured for sale in Canada. For brands that may still be available, ... Amoxicillin - clavulanic acid is usually taken for a period of 7 to 10 days. In some cases, it may be necessary to take this ...
Increased Amoxicillin-Clavulanic Acid Resistance in Escherichia coli Blood Isolates, Spain Jesús Oteo*, José Campos*†. , Edurne ... Increased Amoxicillin-Clavulanic Acid Resistance in Escherichia coli Blood Isolates, Spain. ...
Clavulanic acid biosynthesis - Streptomyces clavuligerus [ Pathway menu , Organism menu , Pathway entry , Download KGML , Image ...
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Amoxicillin-clavulanic acid (Augmentin). *View full drug information. First-line antibiotic for bacterial overgrowth syndrome ... Duodenal bile acids among children: keto derivatives and aerobic small bowel bacterial overgrowth [published erratum appears in ... Hoverstad T, Bjorneklett A, Fausa O, Midtvedt T. Short-chain fatty acids in the small-bowel bacterial overgrowth syndrome. ...
"Clavulanic Acids" by people in this website by year, and whether "Clavulanic Acids" was a major or minor topic of these ... Acids, salts, and derivatives of clavulanic acid (C8H9O5N). They consist of those beta-lactam compounds that differ from ... "Clavulanic Acids" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... Below are the most recent publications written about "Clavulanic Acids" by people in Profiles. ...
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  • The 250 mg and 500 mg tablets of amoxicillin and clavulanic acid contain the same amount of clavulanic acid. (medlineplus.gov)
  • Each concentration includes a different amount of clavulanic acid (Table). (patientcareonline.com)
  • About 25% of total amount of clavulanic acid and 18% of amoxicillin contact proteins in blood plasma. (rxeli.com)
  • The combination of amoxicillin and clavulanic acid is used to treat certain infections caused by bacteria, including infections of the ears, lungs, sinus, skin, and urinary tract. (medlineplus.gov)
  • The combination of amoxicillin and clavulanic acid comes as a tablet, a chewable tablet, an extended-release (long-acting) tablet, and a suspension (liquid) to take by mouth. (medlineplus.gov)
  • Take amoxicillin and clavulanic acid exactly as directed. (medlineplus.gov)
  • Take amoxicillin and clavulanic acid until you finish the prescription, even if you feel better. (medlineplus.gov)
  • Amoxicillin and clavulanic acid also is used sometimes to treat certain sexually transmitted diseases (STD). (medlineplus.gov)
  • tell your doctor and pharmacist if you are allergic to amoxicillin (Amoxil, Trimox, Wymox), clavulanic acid, penicillin, cephalosporins, any other medications, or any of the ingredients in amoxicillin and clavulanic acid preparations. (medlineplus.gov)
  • you should know that amoxicillin and clavulanic acid may decrease the effectiveness of oral contraceptives (birth control pills). (medlineplus.gov)
  • Plan to use another form of birth control while taking amoxicillin and clavulanic acid. (medlineplus.gov)
  • If you become pregnant while taking amoxicillin and clavulanic acid, call your doctor. (medlineplus.gov)
  • Amoxicillin and clavulanic acid may cause side effects. (medlineplus.gov)
  • Skin and Skin Structure Infection,Appropriate culture and susceptibility studies should be performed to identify the causative organism(s) and determine its (their) susceptibility to Amoxicillin and clavulanic acid tablets. (healthdirect.gov.au)
  • The treatment of mixed infections caused by amoxicillin susceptible organisms and beta-lactamase producing organisms susceptible to Amoxicillin and clavulanic acid tablets should not require the addition of another antibiotic due to the amoxicillin content of these products. (healthdirect.gov.au)
  • Concentration of amoxicillin and clavulanic acid in blood serum at reception of a combination of drugs of amoxicillin/clavulanic acid are similar to those which are observed at oral separate administration of an equivalent dose of amoxicillin and clavulanic acid. (rxeli.com)
  • Amoxicillin and clavulanic acid get through a placental barrier. (rxeli.com)
  • Amoxycillin 500mg + Clavulanic Acid 125mg + LB Tablet - Available by the brand name AMRO CV 625 at Servocare Lifesciences, this tablet contains a unification of three rich components that treat certain infections caused by bacteria which includes Amoxycillin, Clavulanic Acid, and LB. Amoxycillin with the dosage of 500 mg is a penicillin antibiotic is used to treat bacterial infections which include urinary tract infections, chest infections, and dental abscesses. (servocarelifesciences.in)
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