New monoterpenoid coumarins from Clausena anisum-olens. (1/14)

Two new monoterpenoid coumarins: anisucumarin A (1) and B (2), a pair of epimers, were isolated from Clausena anisum-olens. Their structures were established based on extensive spectroscopic analyses.  (+info)

Constituents from Clausena excavata. (2/14)

Three new coumarins containing a C(10) terpenoid side chain, clauslactones R - T (1 - 3), together with 14 known coumarins (4 - 17) and 11 known carbazole alkaloids (18 - 28), were isolated from the leaves and stems of Clausena excavata. Their structures were established by detailed spectroscopic analyses. Furthermore, the stereochemistry of 1 was confirmed by single-crystal X-ray diffraction analysis, which was the first example among coumarins with a C(10) terpenoid side chain. Additionally, compounds 22 and 27 were found to show moderate topoisomerase II inhibitory effects at 50 microM.  (+info)

A new O-terpenoidal coumarin from Clausena anisum-olens Merr. (3/14)

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Antioxidant and anticancer activities of wampee (Clausena lansium (Lour.) Skeels) peel. (4/14)

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Coumarins from Clausena anisum-olens Merr. (5/14)

Seven coumarins, including a new O-terpenoidal coumarin, named anisumarin (1), were isolated from Clausena anisum-olens Merr. The structure of this new coumarin was identified as 7-{(E)-4-[(4-acetoxymethyl-1,5-dihydro-5-oxo)-2H-furylium-2-yl]-3-methyl-2-buteno xy}-8-methoxycoumarin on the basis of an extensive spectroscopic analysis.  (+info)

Determination of a pyranocoumarin and three carbazole compounds in Clausena excavata by RP-HPLC. (6/14)

Clausenidin, O-methylmukonal, 3-formyl-2,7-dimethoxycarbazole, and clauszoline-J, isolated from the rhizomes and roots of Clausena excavata, exhibit anti-HIV-1 activity in a syncytial assay with EC(50) values of 5.3, 12.0, 29.1, and 34.2 microM, respectively. Due to the highly active anti-HIV-1 property, quantitative analysis of four compounds are investigated. The direct analysis of these four compounds in the crude extracts of the combined rhizomes and roots of Clausena excavata from ten various sources in Thailand by high-performance liquid chromatography is accomplished. Chromatographic separation is achieved on a C(18) column, and the mobile phase is a mixture of methanol and distilled water in a mode of isocratic or gradient elution detected at 254 nm at a flow rate of 0.6 mL/min for clausenidin, at 274 nm at a flow rate of 0.6 mL/min for O-methylmukonal, at 298 nm at a flow rate of 0.4 mL/min for 3-formyl-2,7-dimethoxycarbazole, and at 242 nm at a flow rate of 0.4 mL/min for clauszoline-J. This is the first quantitative analysis of these four anti-HIV-1 compounds from the crude extract without prior isolation and purification steps.  (+info)

Seed germination and seedling emergence of the invasive exotic species, Clausena excavata. (7/14)

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Evaluation of toxicity of plant extracts against vector of lymphatic filariasis, Culex quinquefasciatus. (8/14)

BACKGROUND & OBJECTIVES: Conventional insecticides are generally used as larvicides to control Culex quinquefasciatus, vector of lymphatic filariasis. This study was undertaken to evaluate the larvicidal activity of some potential larvicidal plants leaf extracts against Cx. quinquefasciatus larvae. METHODS: The toxic effects of petroleum ether leaf extracts of plants viz., Argemone mexicana (Mexican prickly poppy), Clausena dentata (Dentate), Cipadessa baccifera (Rana bili), Dodonaea angustifolia (Hop bush) and Melia dubia (Pride of India) were evaluated under laboratory conditions in individual and in combination against 3 rd - 4 th instar larvae of Cx. quinquefasciatus. RESULTS: The results indicated that among the selected plants, A. mexicana showed maximum larvicidal activity with an LC 50 value of 48.89 ppm. Its toxicity was enhanced when the extract was mixed (1:1) with that of C. dentata as the LC 50 value became 28.60 ppm indicating synergistic action of A. mexicana. INTERPRETATION & CONCLUSIONS: Our results showed high larvicidal potential in A. mexicana leaf extract, and it also showed additive effect when mixed with C. dentata extract.  (+info)

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