Claudins
Claudin-3
Claudin-4
Tight Junctions
Claudin-1
Occludin
Claudin-5
Membrane Proteins
Zonula Occludens-2 Protein
Claudin-2
MARVEL Domain Containing 2 Protein
Zonula Occludens-1 Protein
Zonula Occludens Proteins
Clostridium perfringens
Permeability
Epithelial Cells
Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.
Loop of Henle
Dogs
Madin Darby Canine Kidney Cells
Cell Membrane Permeability
Junctional Adhesion Molecules
Keratosis, Actinic
Freeze Fracturing
Preparation for electron microscopy of minute replicas of exposed surfaces of the cell which have been ruptured in the frozen state. The specimen is frozen, then cleaved under high vacuum at the same temperature. The exposed surface is shadowed with carbon and platinum and coated with carbon to obtain a carbon replica.
PubMed
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
Publishing
MEDLINE
Neoplastic Stem Cells
Gap Junctions
Connections between cells which allow passage of small molecules and electric current. Gap junctions were first described anatomically as regions of close apposition between cells with a narrow (1-2 nm) gap between cell membranes. The variety in the properties of gap junctions is reflected in the number of CONNEXINS, the family of proteins which form the junctions.
Desmoplakins
Desmosomes
A type of junction that attaches one cell to its neighbor. One of a number of differentiated regions which occur, for example, where the cytoplasmic membranes of adjacent epithelial cells are closely apposed. It consists of a circular region of each membrane together with associated intracellular microfilaments and an intercellular material which may include, for example, mucopolysaccharides. (From Glick, Glossary of Biochemistry and Molecular Biology, 1990; Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
Intercellular Junctions
Direct contact of a cell with a neighboring cell. Most such junctions are too small to be resolved by light microscopy, but they can be visualized by conventional or freeze-fracture electron microscopy, both of which show that the interacting CELL MEMBRANE and often the underlying CYTOPLASM and the intervening EXTRACELLULAR SPACE are highly specialized in these regions. (From Alberts et al., Molecular Biology of the Cell, 2d ed, p792)
Blood-Brain Barrier
Endothelial Cells
Highly specialized EPITHELIAL CELLS that line the HEART; BLOOD VESSELS; and lymph vessels, forming the ENDOTHELIUM. They are polygonal in shape and joined together by TIGHT JUNCTIONS. The tight junctions allow for variable permeability to specific macromolecules that are transported across the endothelial layer.
Brain
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Neural Crest
The two longitudinal ridges along the PRIMITIVE STREAK appearing near the end of GASTRULATION during development of nervous system (NEURULATION). The ridges are formed by folding of NEURAL PLATE. Between the ridges is a neural groove which deepens as the fold become elevated. When the folds meet at midline, the groove becomes a closed tube, the NEURAL TUBE.
Molecular Biology
Snails
Transcription Factors
Mesoderm
Colorectal Neoplasms
Hyperammonemia
Stem Cell Factor
Hematopoietic Cell Growth Factors
These growth factors comprise a family of hematopoietic regulators with biological specificities defined by their ability to support proliferation and differentiation of blood cells of different lineages. ERYTHROPOIETIN and the COLONY-STIMULATING FACTORS belong to this family. Some of these factors have been studied and used in the treatment of chemotherapy-induced neutropenia, myelodysplastic syndromes, and bone marrow failure syndromes.
Proto-Oncogene Proteins c-kit
A protein-tyrosine kinase receptor that is specific for STEM CELL FACTOR. This interaction is crucial for the development of hematopoietic, gonadal, and pigment stem cells. Genetic mutations that disrupt the expression of PROTO-ONCOGENE PROTEINS C-KIT are associated with PIEBALDISM, while overexpression or constitutive activation of the c-kit protein-tyrosine kinase is associated with tumorigenesis.
Copyright
It is a form of protection provided by law. In the United States this protection is granted to authors of original works of authorship, including literary, dramatic, musical, artistic, and certain other intellectual works. This protection is available to both published and unpublished works. (from Circular of the United States Copyright Office, 6/30/2008)
Enterocolitis, Necrotizing
Claudin-11/OSP-based tight junctions of myelin sheaths in brain and Sertoli cells in testis. (1/444)
Members of the newly identified claudin gene family constitute tight junction (TJ) strands, which play a pivotal role in compartmentalization in multicellular organisms. We identified oligodendrocyte-specific protein (OSP) as claudin-11, a new claudin family member, due to its sequence similarity to claudins as well as its ability to form TJ strands in transfected fibroblasts. Claudin-11/OSP mRNA was expressed in the brain and testis. Immunofluorescence microscopy with anti-claudin-11/OSP polyclonal antibody (pAb) and anti-neurofilament mAb revealed that in the brain claudin-11/OSP-positive linear structures run in a gentle spiral around neurofilament-positive axons. At the electron microscopic level, these linear structures were identified as the so-called interlamellar strands in myelin sheaths of oligodendrocytes. In testis, well-developed TJ strands of Sertoli cells were specifically labeled with anti-claudin-11/OSP pAb both at immunofluorescence and electron microscopic levels. These findings indicated that the interlamellar strands of oligodendrocyte myelin sheaths can be regarded as a variant of TJ strands found in many other epithelial cells, and that these strands share a specific claudin species, claudin-11/OSP, with those in Sertoli cells to create and maintain the repeated compartments around axons by oligodendrocytes. (+info)Transmembrane proteins in the tight junction barrier. (2/444)
Three types of transmembrane proteins have been identified within the tight junction, but it remains to be determined how they provide the molecular basis for regulating the paracellular permeability for water, solutes, and immune cells. Several of these proteins localize specifically within the continuous cell-to-cell contacts of the tight junction. One of these, occludin, is a cell adhesion molecule that has been demonstrated to influence ion and solute permeability. The claudins are a family of four-membrane spanning proteins; unexpectedly, other members of this family have already been characterized without recognizing their relationship to tight junctions. Junction adhesion molecule, the most recently identified tight junction component, is a member of the Ig superfamily and influences the paracellular transmigration of immune cells. A plaque of cytoplasmic proteins under the junction may be responsible for scaffolding the transmembrane proteins, creating a link to the perijunctional actin cytoskeleton and transducing regulatory signals that control the paracellular barrier. (+info)Paracellin-1, a renal tight junction protein required for paracellular Mg2+ resorption. (3/444)
Epithelia permit selective and regulated flux from apical to basolateral surfaces by transcellular passage through cells or paracellular flux between cells. Tight junctions constitute the barrier to paracellular conductance; however, little is known about the specific molecules that mediate paracellular permeabilities. Renal magnesium ion (Mg2+) resorption occurs predominantly through a paracellular conductance in the thick ascending limb of Henle (TAL). Here, positional cloning has identified a human gene, paracellin-1 (PCLN-1), mutations in which cause renal Mg2+ wasting. PCLN-1 is located in tight junctions of the TAL and is related to the claudin family of tight junction proteins. These findings provide insight into Mg2+ homeostasis, demonstrate the role of a tight junction protein in human disease, and identify an essential component of a selective paracellular conductance. (+info)Ca(2+)-independent cell-adhesion activity of claudins, a family of integral membrane proteins localized at tight junctions. (4/444)
In multicellular organisms, various compositionally distinct fluid compartments are established by epithelial and endothelial cellular sheets. For these cells to function as barriers, tight junctions (TJs) are considered to create a primary barrier for the diffusion of solutes through the paracellular pathway [1] [2] [3]. In ultrathin sections viewed under electron microscopy, TJs appear as a series of apparent fusions, involving the outer leaflets of plasma membranes of adjacent cells, to form the so-called kissing points of TJs, where the intercellular space is completely obliterated [4]. Claudins are a family of 16 proteins whose members have been identified as major integral membrane proteins localized exclusively at TJs [5] [6] [7] [8]. It remains unclear, however, whether claudins have the cell-adhesion activity that would explain the unusual intercellular adhesion at TJs. Using mouse L-fibroblast transfectants expressing various amounts of claudin-1, -2 or -3, we found that these claudins possess Ca(2+)-independent cell-adhesion activity. Using ultrathin-section electron microscopy, we observed many kissing points of TJs between adjacent transfectants. Furthermore, the cell-adhesion activity of occludin, another integral membrane protein localized at TJs [9] [10] [11], was negligible when compared with that of claudins. Thus, claudins are responsible for TJ-specific obliteration of the intercellular space. (+info)Endothelial claudin: claudin-5/TMVCF constitutes tight junction strands in endothelial cells. (5/444)
Tight junctions (TJs) in endothelial cells are thought to determine vascular permeability. Recently, claudin-1 to -15 were identified as major components of TJ strands. Among these, claudin-5 (also called transmembrane protein deleted in velo-cardio-facial syndrome [TMVCF]) was expressed ubiquitously, even in organs lacking epithelial tissues, suggesting the possible involvement of this claudin species in endothelial TJs. We then obtained a claudin-6-specific polyclonal antibody and a polyclonal antibody that recognized both claudin-5/TMVCF and claudin-6. In the brain and lung, immunofluorescence microscopy with these polyclonal antibodies showed that claudin-5/TMVCF was exclusively concentrated at cell-cell borders of endothelial cells of all segments of blood vessels, but not at those of epithelial cells. Immunoreplica electron microscopy revealed that claudin-5/TMVCF was a component of TJ strands. In contrast, in the kidney, the claudin-5/TMVCF signal was restricted to endothelial cells of arteries, but was undetectable in those of veins and capillaries. In addition, in all other tissues we examined, claudin-5/TMVCF was specifically detected in endothelial cells of some segments of blood vessels, but not in epithelial cells. Furthermore, when claudin-5/TMVCF cDNA was introduced into mouse L fibroblasts, TJ strands were reconstituted that resembled those in endothelial cells in vivo, i.e., the extracellular face-associated TJs. These findings indicated that claudin-5/TMVCF is an endothelial cell-specific component of TJ strands. (+info)Clostridium perfringens enterotoxin fragment removes specific claudins from tight junction strands: Evidence for direct involvement of claudins in tight junction barrier. (6/444)
Claudins, comprising a multigene family, constitute tight junction (TJ) strands. Clostridium perfringens enterotoxin (CPE), a single approximately 35-kD polypeptide, was reported to specifically bind to claudin-3/RVP1 and claudin-4/CPE-R at its COOH-terminal half. We examined the effects of the COOH-terminal half fragment of CPE (C-CPE) on TJs in L transfectants expressing claudin-1 to -4 (C1L to C4L, respectively), and in MDCK I cells expressing claudin-1 and -4. C-CPE bound to claudin-3 and -4 with high affinity, but not to claudin-1 or -2. In the presence of C-CPE, reconstituted TJ strands in C3L cells gradually disintegrated and disappeared from their cell surface. In MDCK I cells incubated with C-CPE, claudin-4 was selectively removed from TJs with its concomitant degradation. At 4 h after incubation with C-CPE, TJ strands were disintegrated, and the number of TJ strands and the complexity of their network were markedly decreased. In good agreement with the time course of these morphological changes, the TJ barrier (TER and paracellular flux) of MDCK I cells was downregulated by C-CPE in a dose-dependent manner. These findings provided evidence for the direct involvement of claudins in the barrier functions of TJs. (+info)Manner of interaction of heterogeneous claudin species within and between tight junction strands. (7/444)
In tight junctions (TJs), TJ strands are associated laterally with those of adjacent cells to form paired strands to eliminate the extracellular space. Claudin-1 and -2, integral membrane proteins of TJs, reconstitute paired TJ strands when transfected into L fibroblasts. Claudins comprise a multigene family and more than two distinct claudins are coexpressed in single cells, raising the questions of whether heterogeneous claudins form heteromeric TJ strands and whether claudins interact between each of the paired strands in a heterophilic manner. To answer these questions, we cotransfected two of claudin-1, -2, and -3 into L cells, and detected their coconcentration at cell-cell borders as elaborate networks. Immunoreplica EM confirmed that distinct claudins were coincorporated into individual TJ strands. Next, two L transfectants singly expressing claudin-1, -2, or -3 were cocultured and we found that claudin-3 strands laterally associated with claudin-1 and -2 strands to form paired strands, whereas claudin-1 strands did not interact with claudin-2 strands. We concluded that distinct species of claudins can interact within and between TJ strands, except in some combinations. This mode of assembly of claudins could increase the diversity of the structure and functions of TJ strands. (+info)Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins. (8/444)
ZO-1, ZO-2, and ZO-3, which contain three PDZ domains (PDZ1 to -3), are concentrated at tight junctions (TJs) in epithelial cells. TJ strands are mainly composed of two distinct types of four-transmembrane proteins, occludin, and claudins, between which occludin was reported to directly bind to ZO-1/ZO-2/ZO-3. However, in occludin-deficient intestinal epithelial cells, ZO-1/ZO-2/ZO-3 were still recruited to TJs. We then examined the possible interactions between ZO-1/ZO-2/ZO-3 and claudins. ZO-1, ZO-2, and ZO-3 bound to the COOH-terminal YV sequence of claudin-1 to -8 through their PDZ1 domains in vitro. Then, claudin-1 or -2 was transfected into L fibroblasts, which express ZO-1 but not ZO-2 or ZO-3. Claudin-1 and -2 were concentrated at cell-cell borders in an elaborate network pattern, to which endogenous ZO-1 was recruited. When ZO-2 or ZO-3 were further transfected, both were recruited to the claudin-based networks together with endogenous ZO-1. Detailed analyses showed that ZO-2 and ZO-3 are recruited to the claudin-based networks through PDZ2 (ZO-2 or ZO-3)/PDZ2 (endogenous ZO-1) and PDZ1 (ZO-2 or ZO-3)/COOH-terminal YV (claudins) interactions. In good agreement, PDZ1 and PDZ2 domains of ZO-1/ZO-2/ZO-3 were also recruited to claudin-based TJs, when introduced into cultured epithelial cells. The possible molecular architecture of TJ plaque structures is discussed. (+info)
Defining the Genomic and Epigenomic Plasticity of Basal and Claudin-low Breast Cancer - UNC Lineberger Comprehensive Cancer...
IJMS | Free Full-Text | Emerging Roles of Claudins in Human Cancer
Met synergizes with p53 loss to induce mammary tumors that possess features of claudin-low breast cancer
Significance of glioma-associated oncogene homolog 1 (GLI1) expression in claudin-low breast cancer and crosstalk with the...
JCI -
Welcome
Magiran | Metastasis inhibition by BRMS1 and miR-31 replacement therapy in claudin-low cell lines
Claudin 13, a member of the claudin family regulated in mouse stress induced erythropoiesis
Claudin - Wikipedia
GGRNA | Results
EDB [Morimoto Shinya/[西村 範行]/Terai Tomoya/Manabe Shinji/Yamamoto Yasuyo/Shinahara Wakako/Miyake Hidenori/Tashiro Seiki/[島田 光生]/...
Expression and localization of claudins-3 and -12 in transformed human brain endothelium - Open Research Online
OSP/claudin-11 forms a complex with a novel member of the tetraspanin super family and beta1 integrin and regulates...
Regulation of tight junctions during the epithelium-mesenchyme transition: direct repression of the gene expression of claudins...
PubMedPro - claudins colorectal cancer
Cldn15 MGI Mouse Gene Detail - MGI:1913103 - claudin 15
Claudin 16 (CLDN16) ELISA Kits
Claudin 18 (CLDN18) Antikörper
Claudin-19 Mutations and Clinical Phenotype in Spanish Patients with Familial Hypomagnesemia with Hypercalciuria and...
Claudins and epithelial paracellular transport. - PubMed - NCBI
The Biology of Claudin 6 (Cldn6) in the Developing Mouse Lung by Felix Ruben Jimenez Rondan
Untersuchungen zu parazellulären Barriereeigenschaften von Claudinen
Tight junction-related structures in the absence of a lumen: occludin, claudins and tight junction plaque proteins in densely...
TumorPortal
August, 2015 | emailexporter.com
November 2017 - Pathways and therapeutic targets in Cancer therapy
CLDN5 ENST00000618236 Gene - Somatic Mutations in Cancer
CLDN18 Gene - GeneCards | CLD18 Protein | CLD18 Antibody
Laredo Petroleum, Inc. (LPI) 最新股價淨值比為-6.28倍,比90.87%公司低 | 財報狗股票
Barriers and Channels Formed by Tight Junction Proteins I, Volume 1257 | Wiley
CLDN16 Genotype Predicts Renal Decline in Familial Hypomagnesemia with Hypercalciuria and Nephrocalcinosis | American Society...
The Involvement of Tight Junction Protein Claudin-1 in Hepatitis C Virus Entry - NDM Research Building
The Involvement of Tight Junction Protein Claudin-1 in Hepatitis C Virus Entry - NDM Research Building
CLDN16 gene - Genetics Home Reference - NIH
Search Results | Journal of Cell Biology | Rockefeller University Press
PA-824
USE OF HYALURONIC ACID FOR THE PREPARATION OF COMPOSITIONS INTENDED FOR IMPROVING IN PARTICULAR THE PROTECTIVE FUNCTION OF THE...
Plus it
Long term culture of MDCK strains alters chromosome content. - Inserm
Search Results | Journal of Cell Biology | Rockefeller University Press
Claudin 7 Antibody 10118-1-AP | Proteintech
Recombinant Mouse Cldn4 Protein, MYC/DDK-tagged Cldn4-901M - Creative BioMart
WikiGenes - CLDN2 - claudin 2
CLDN1 purified MaxPab mouse polyclonal antibody (B01P) - (H00009076-B01P) - Products - Abnova
Familial hypomagnesaemia, Hypercalciuria and Nephrocalcinosis associated with a novel mutation of the highly conserved leucine...
Tight junctions (TJs) are constructions indispensable to epithelial cells and are - PI3K Signaling in B and T Lymphocytes
Impact of Hyperosmotic Glycerol on Tighy Junction In Vitro
Plus it
Difference between revisions of 2011 Group 3 Project - CellBiology
2011 Group 3 Project - CellBiology
Blood brain barrier: Fluid Transfer
CLDN8 | definition of CLDN8 by Medical dictionary
CLDN7 (Human) Recombinant Protein (Q01) - (H00001366-Q01) - Products - Abnova
CLDN1
It belongs to the group of claudins. Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial ... Swisshelm K, Macek R, Kubbies M (2005). "Role of claudins in tumorigenesis". Adv. Drug Deliv. Rev. 57 (6): 919-28. doi:10.1016/ ... with the COOH termini of claudins". J. Cell Biol. 147 (6): 1351-63. doi:10.1083/jcb.147.6.1351. PMC 2168087. PMID 10601346. ...
Tight junction proteins
Claudins seem to be on a tissue specific manner, because some of them are expressed only in a specific cell type. Claudin 11 is ... Claudins also have a function in a signaling of the cell adhesion, for example Cldn 7 binds directly to adhesion molecule EpCAM ... Most types of claudins have more than two isoforms, that have a distinguish size or function. The specific combination of these ... The C-terminal domain of claudins is required for their stability and targeting. This domain contains PDZ-binding motif, that ...
CLDN12
2004). "Expression patterns of claudins, tight junction adhesion molecules, in the inner ear". Hear. Res. 187 (1-2): 25-34. doi ... It belongs to the group of claudins. GRCh38: Ensembl release 89: ENSG00000157224 - Ensembl, May 2017 GRCm38: Ensembl release 89 ... 2002). "Differential expression patterns of claudins, tight junction membrane proteins, in mouse nephron segments". J. Am. Soc ...
CLDN20
It belongs to the group of claudins. GRCh38: Ensembl release 89: ENSG00000171217 - Ensembl, May 2017 "Human PubMed Reference ...
CLDN4
It belongs to the group of claudins. This gene encodes an integral membrane protein, which belongs to the claudin family. The ... 2000). "Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins". J. ...
CLDN5
It belongs to the group of claudins. This gene encodes a member of the claudin family. Claudins are integral membrane proteins ... Poliak S, Matlis S, Ullmer C, Scherer SS, Peles E (2002). "Distinct claudins and associated PDZ proteins form different ... with the COOH termini of claudins". J. Cell Biol. 147 (6): 1351-63. doi:10.1083/jcb.147.6.1351. PMC 2168087. PMID 10601346. ...
CLDN7
It belongs to the group of claudins. Claudins, such as CLDN7, are involved in the formation of tight junctions between ... 2000). "Direct Binding of Three Tight Junction-Associated Maguks, Zo-1, Zo-2, and Zo-3, with the Cooh Termini of Claudins". J. ...
CLDN9
It belongs to the group of claudins. This gene is involved in hearing. GRCh38: Ensembl release 89: ENSG00000213937 - Ensembl, ... 2004). "Expression patterns of claudins, tight junction adhesion molecules, in the inner ear". Hear. Res. 187 (1-2): 25-34. doi ... 2002). "Differential expression patterns of claudins, tight junction membrane proteins, in mouse nephron segments". J. Am. Soc ...
CLDN8
2000). "Direct Binding of Three Tight Junction-Associated Maguks, Zo-1, Zo-2, and Zo-3, with the Cooh Termini of Claudins". J. ... It belongs to the group of claudins. GRCh38: Ensembl release 89: ENSG00000156284 - Ensembl, May 2017 GRCm38: Ensembl release 89 ...
CLDN22
It belongs to the group of claudins. GRCh38: Ensembl release 89: ENSG00000177300 - Ensembl, May 2017 GRCm38: Ensembl release 89 ...
CLDN10
It belongs to the group of claudins. This gene encodes a member of the claudin family. Claudins are integral membrane proteins ... 2000). "Ca(2+)-independent cell-adhesion activity of claudins, a family of integral membrane proteins localized at tight ...
CLDN18
It belongs to the group of claudins. CLDN18 belongs to the large claudin family of proteins, which form tight junction strands ...
CLDN19
It belongs to the group of claudins. Claudin-19 has been implicated in magnesium transport. Claudins, such as CLDN19, are ...
CLDN15
2002). "Claudins create charge-selective channels in the paracellular pathway between epithelial cells" (PDF). Am. J. Physiol ... It belongs to the group of claudins. Among its related pathways are Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/ ... 2002). "Differential expression patterns of claudins, tight junction membrane proteins, in mouse nephron segments". J. Am. Soc ... "Reversal of charge selectivity in cation or anion-selective epithelial lines by expression of different claudins". Am. J. ...
CLDN6
2000). "Direct Binding of Three Tight Junction-Associated Maguks, Zo-1, Zo-2, and Zo-3, with the Cooh Termini of Claudins". J. ... It belongs to the group of claudins. The knockout mice of mouse homolog exhibit no phenotype, indicating that claudin-6 is ... 2003). "The renal segmental distribution of claudins changes with development". Kidney Int. 62 (2): 476-87. doi:10.1046/j.1523- ... 2002). "Differential expression patterns of claudins, tight junction membrane proteins, in mouse nephron segments". J. Am. Soc ...
CLDN16
It belongs to the group of claudins. Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial ...
CLDN2
It belongs to the group of claudins. Members of the claudin protein family, such as CLDN2, are expressed in an organ-specific ... 2000). "Direct Binding of Three Tight Junction-Associated Maguks, Zo-1, Zo-2, and Zo-3, with the Cooh Termini of Claudins". J. ... 2004). "Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudins". Proc. Natl. Acad ...
Intestinal epithelium
Khan, Niamat; Asif, Abdul R. (1 January 2015). "Transcriptional Regulators of Claudins in Epithelial Tight Junctions". ...
Intestinal permeability
Cite journal requires ,journal= (help) Khan, Niamat; Asif, Abdul R. (2015-01-01). "Transcriptional Regulators of Claudins in ...
Magnesium transporter
Claudins allow for Mg2+ transport via the paracellular pathway; that is, it mediates the transport of the ion through the tight ...
CLDN14
It belongs to a related family of proteins called claudins. The protein encoded by CLDN14 is an integral membrane protein and a ... Van Itallie CM, Gambling TM, Carson JL, Anderson JM (2005). "Palmitoylation of claudins is required for efficient tight- ...
Claudin
Claudins create both cis and trans strand formation between cell membranes. Claudins were first named in 1998 by Japanese ... It is suspected that the cysteines of individual or separate claudins form disulfide bonds. All human claudins (with the ... Claudins span the cellular membrane 4 times, with the N-terminal end and the C-terminal end both located in the cytoplasm, and ... Claudins are a family of proteins which, along with occludin, are the most important components of the tight junctions (zonulae ...
Tight junction
Claudins were discovered after occludin and are a family of 24 different mammalian proteins. They have a molecular weight of ~ ... Different claudins are found in different locations throughout the human body. Junction Adhesion Molecules (JAM) are part of ... The three major transmembrane proteins are occludin, claudins, and junction adhesion molecule (JAM) proteins. These associate ...
Claudin 25
Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical ...
Paracellular transport
Some claudins form tight junction-associated pores that allow paracellular ion transport. The tight junctions have a net ...
Uterine epithelium
Colegio, O. R., Van Itallie, C. M., McCrea, H. J., Rahner, C., & Anderson, J. M. (2002). Claudins create charge-selective ... Nicholson, M., Lindsay, L. A., & Murphy, C. R. (2010). Ovarian hormones control the changing expression of claudins and ...
Junctional adhesion molecule
JAM-1 also regulates the activity of many different claudins within different epithelial cells. Angiogenesis is the generation ...
MPDZ
Poliak S, Matlis S, Ullmer C, Scherer SS, Peles E (2002). "Distinct claudins and associated PDZ proteins form different ...
Septate junction
There are three known claudins contained in the septate junctions, Megatrachea (Mega), Sinuous (Sinu) and Kune-kune (Kune). ... Among these three claudins, Kune-kune (Kune) plays a more central role in septate junctions organization and function. There ...
SNAI1
... direct repression of the gene expression of claudins/occludin by Snail". Journal of Cell Science. 116 (Pt 10): 1959-67. doi: ...
Claudins and epithelial paracellular transport. - PubMed - NCBI
Claudins and epithelial paracellular transport.. Van Itallie CM1, Anderson JM.. Author information. 1. Department of Medicine, ... Recent evidence shows that claudins, a large family (at least 24 members) of intercellular adhesion molecules, form the seal ... This evidence comes from the study of claudins expressed in cultured epithelial cell models, genetically altered mice, and ...
IJMS | Free Full-Text | Emerging Roles of Claudins in Human Cancer
The involvement of claudins in tumor progression was suggested by their important role in the migration, invasion and ... A better understanding of the emerging role of claudins in CSC/TICs and chemoresistance may help to develop therapies against ... Although their dysregulation in cancer suggests that claudins play a role in tumorigenesis, the exact underlying mechanism ... suggesting that claudins are promising targets for the treatment of chemoresistant and recurrent tumors. A recently identified ...
JCI -
Matriptase-mediated cleavage of EpCAM destabilizes claudins and dysregulates intestinal epithelial homeostasis
Toxins | Free Full-Text | On the Interaction of Clostridium perfringens Enterotoxin with Claudins
The C-terminal region (cCPE) binds to the second extracellular loop of a subset of claudins. Claudin-3 and claudin-4 have been ... The toxin binds with weak affinity to claudin-1 and -2 but contribution of these weak binding claudins to CPE-mediated disease ... and CPE-based peptidomimetics to modulate tight junctions for improved drug delivery or to treat tumors overexpressing claudins ... Keywords: Claudins; Clostridium perfringens enterotoxin; drug delivery; tight junction Claudins; Clostridium perfringens ...
Claudins in a primary cultured puffer fish (Tetraodon nigroviridis) gill epithelium
Claudins and the Kidney | American Society of Nephrology
Regulation of claudins by post-translational modifications and cell signaling cascades. In: Claudins, edited by Yu AS, ... Claudins in Human Kidney Diseases. The first inherited disorder of claudins to be identified was FHHNC.70 This autosomal ... Role of Claudins in the Aldosterone-Sensitive Distal Nephron. *Regulation of ASDN Claudins by Aldosterone and With-No-Lysine ... Expression of Claudins in the Kidney. Most claudins are expressed in the renal tubule. Each segment and cell expresses multiple ...
Heterogeneity in expression and subcellular localization of claudins 2, 3, 4, and 5 in the rat liver, pancreas, and gut. -...
Rabbit polyclonal antibodies were produced against peptides from claudins 2 through 5. The distribution of individual claudins ... Claudins have very different expression patterns among and within gastrointestinal tissues. We propose these patterns underlie ... Heterogeneity in expression and subcellular localization of claudins 2, 3, 4, and 5 in the rat liver, pancreas, and gut.. ... and the finding that some claudins can be junctional, lateral, or show a gradient in junctional vs. lateral localization along ...
Shop Claudins: Methods And Protocols
not a shop Claudins: Methods while we focus you in to your property Y. The Web request that you received is only a responding ... The shop Claudins: Methods is on the Deep gala of the Warwalks by the Wasp-kinden bunch. walked-with-purpose of the Apt argues ... shop Claudins: knows near, non-critical, and provides us help you better! challenge a website to destroy a s plan. age agents 1 ... re-equip shop Claudins: Methods and across the something. That accepted to teach a mass teacher. But it has back a hundred ...
Tight junction-related structures in the absence of a lumen: occludin, claudins and tight junction plaque proteins in densely...
Mucosal Expression of Claudins 2, 3 and 4 in Proximal and Distal Part of Duodenum in Children with Celiac Disease - Celiac.com
Celiac.com 03/15/2010 A team of researchers recently set out to investigate mucosal expression of claudins 2, 3 and 4 in the ... Mucosal Expression of Claudins 2, 3 and 4 in Proximal and Distal Part of Duodenum in Children with Celiac Disease ... Mucosal Expression of Claudins 2, 3 and 4 in Proximal and Distal Part of Duodenum in Children with Celiac Disease ... Mucosal Expression of Claudins 2, 3 and 4 in Proximal and Distal Part of Duodenum in Children with Celiac Disease ...
Expression and localization of claudins-3 and -12 in transformed human brain endothelium - Open Research Online
... for the expression of brain endothelial specific claudins-3 and -12. Findings: hCMEC/D3 cells express claudins-3 and -12. ... Expression and localization of claudins-3 and -12 in transformed human brain endothelium.. Fluids and barriers of the CNS, 9 p ... blood brain barrier (BBB); hCMEC/D3; claudins; tight junction; statins. Academic Unit/School:. Faculty of Science, Technology, ... Expression and localization of claudins-3 and -12 in transformed human brain endothelium ...
E7 oncoprotein from human papillomavirus 16 alters claudins expression and the sealing of epithelial tight junctions
For example, in lung squamous cell carcinomas claudins -1, -2, -4 and -7 are expressed, while claudins -2, -3, -4, -5 and -7 ... the role of claudins, in particular claudins -1 (136,137), -2 (46,125,138), -4 (46,125,126) and -10 (33,139) has been ... claudins -2, -3 and -4), even though they are no longer present at the cell borders (23). With respect to claudins, there are ... Claudins -1, -4, -5 and -7 are expressed in the squamous cell carcinomas found in the oral cavity, while claudin-1 is expressed ...
Regulation of tight junctions during the epithelium-mesenchyme transition: direct repression of the gene expression of claudins...
... occludin and claudins (Furuse et al., 1993; Furuse et al., 1998a; Furuse et al., 1998b). Both occludin and claudins bear four ... Claudins and occludin are thought to constitute the backbone of TJ strands and to modulate some functions of TJs, respectively ... Claudins and occludin are integral membrane proteins localized at tight junctions, which are responsible for establishing and ... Tsukita, S. and Furuse, M. (1999b). Occludin and claudins in tight-junction strands: leading or supporting players? Trend Cell ...
Effect of claudins 6 and 9 on paracellular permeability in MDC...
Effect of claudins 6 and 9 on paracellular permeability in MDCK II cells.: The neonatal proximal tubule has a lower ... Effect of claudins 6 and 9 on paracellular permeability in MDCK II cells.. Authors * Sas, David ... We transfected claudins 6 and 9 into Madin-Darby canine kidney II (MDCK II) cells and performed electrophysiological studies to ... Expression of claudins 6 and 9 resulted in an increased transepithelial resistance, decreased chloride permeability, and ...
Claudins in intestines
July 2013). Claudins in intestines. Tissue Barriers, (1:3), p.1-14. Retrieved from http://hdl.handle.net/10342/5297 Display/ ... Lu, Zhe and Ding, Lei and Lu, Qun and Chen, Yan-Hua, "Claudins in intestines," Tissue Barriers 1, no. 3 (July 2013), http://hdl ... Claudins in intestines. Tissue Barriers. July 2013; 1(3) 1-14. http://hdl.handle.net/10342/5297. Accessed March 08, 2021. ... "Claudins in intestines". Tissue Barriers. 1:3. (1-14.), July 2013. March 08, 2021. http://hdl.handle.net/10342/5297. ...
Search Results - 'Claudins.'
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PubMedPro - claudins colorectal cancer
In gastrointestinal tract, claudins are mainly located in the intestinal epithelia; many types of claudins form a network of ... Claudins are transmembrane proteins important for tight junctions. Claudins regulate the paracellular transport and are crucial ... RESULTS:Immunohistochemical staining with claudins antibodies had membranous pattern; claudins expression in adjacent normal ... claudins form tight junctions together with occludin. Several claudins were shown to be up-regulated in various cancer types. ...
Claudins and Other Tight Junction Proteins - Comprehensive Physiology
... a significant number of claudins form channels across TJs which feature selectivity for cations (claudins 2, 10b, and 15), ... Claudins in cancer biology. Curr Top Membr 65: 293‐333, 2010. 258.. Van Deurs B, Koehler JK. Tight junctions in the choroid ... The claudins. Genome Biol 10: 235.1‐235.7, 2009. 146.. Lemmers C, Michel D, Lane‐Guermonprez L, Delgrossi MH, Médina E, Arsanto ... C) Model of cis and trans interactions between the claudins 1, 2, 3, 5, and 12 and working hypothesis for TJ assembly. Step 1 ...
The Diagnostic Role of Claudins in Serous Effusions
... American Journal of Clinical Pathology 2007 Jun;127(6):928-37. [Link] ... We analyzed the diagnostic role of claudins in effusion cytology in 325 effusions, including 218 ovarian, 49 breast, 15 ... Reactive mesothelial cells rarely expressed claudins. Claudin-7 expression was higher in ovarian than in breast adenocarcinoma ...
Expression and localization of claudins-3 and -12 in transformed human brain endothelium | Fluids and Barriers of the CNS |...
... for the expression of brain endothelial specific claudins-3 and -12. hCMEC/D3 cells express claudins-3 and -12. Claudin-3 is ... Expression and localization of claudins-3 and -12 in transformed human brain endothelium. *Anja Schrade1,7. , ... The cells express endothelial specific and TJ markers including claudins-1 and -5 [8, 9]. The aim of the present study was to ... Like other claudins, it is regulated by post-translational modifications, a possible reason for the higher molecular weight ...
Handbook of Thin Film Deposition / Edition 3 by Krishna Seshan | 9781437778731 | Hardcover | Barnes & Noble®
Claudins play a role in normal and tumor cell motility | BMC Cell Biology | Full Text
20] that claudins have the potential to interact with MT1-MMP to activate MMP-2, suggest that claudins may increase MMP ... Extra-junctional claudins have been traditionally attributed to storage and mobilization of claudins to and from the tight ... Although it is still unclear how claudins may promote cell motility, it is becoming clear that claudins are indeed playing an ... Claudins -3, -4 and -7 are often present in breast [6-8], ovarian [9-11], and endometrial [12, 13] tumors and are often ...
IJMS | Free Full-Text | SCF/C-Kit/JNK/AP-1 Signaling Pathway Promotes Claudin-3 Expression in Colonic Epithelium and Colorectal...
Tight Junctions in Salivary Epithelium
... from the 24 known claudins, only claudins-1, -8, -10, -11, and -16 have been detected in salivary glands. These claudins (i.e ... Claudins. Claudins are members of a multigene family, with , 24 members in humans/rodents [61], presenting a unique tissue ... K. Turksen and T.-C. Troy, "Barriers built on claudins," Journal of Cell Science, vol. 117, no. 12, pp. 2435-2447, 2004. View ... S. Tsukita and M. Furuse, "The structure and function of claudins, cell adhesion molecules at tight junctions," Annals of the ...
RCSB PDB - 3X29: CRYSTAL STRUCTURE of MOUSE CLAUDIN-19 IN COMPLEX with C-TERMINAL FRAGMENT OF CLOSTRIDIUM PERFRINGENS...
The claudin-19/C-CPE complex shows no density of a short extracellular helix that is critical for claudins to assemble into TJ ... The C-terminal region of Clostridium perfringens enterotoxin (C-CPE) can bind to specific claudins, resulting in the ... The C-terminal region of Clostridium perfringens enterotoxin (C-CPE) can bind to specific claudins, resulting in the ...
Hypomagnesemia: Background, Pathophysiology, Etiology
Advances in the application of claudins to tumor therapy | Chinese Journal of Biotechnology;(12): 931-941, 2019. | WPRIM
In recent years, many studies have shown that abnormality of claudins expression is implicated in the tumor progression. The ... Claudins / Neoplasms Language: Chinese Journal: Chinese Journal of Biotechnology Year: 2019 Type: Article ... Claudins / Neoplasms Language: Chinese Journal: Chinese Journal of Biotechnology Year: 2019 Type: Article ... Advances in the application of claudins to tumor therapy / 生物工程学报 ...
Bifidobacteria stabilize claudins at tight junctions and prevent intestinal barrier dysfunction in mouse necrotizing...
title = "Bifidobacteria stabilize claudins at tight junctions and prevent intestinal barrier dysfunction in mouse necrotizing ... T1 - Bifidobacteria stabilize claudins at tight junctions and prevent intestinal barrier dysfunction in mouse necrotizing ... Bifidobacteria stabilize claudins at tight junctions and prevent intestinal barrier dysfunction in mouse necrotizing ... Bifidobacteria stabilize claudins at tight junctions and prevent intestinal barrier dysfunction in mouse necrotizing ...
A strategy for enrichment of claudins based on their affinity to Clostridium perfringens enterotoxin | BMC Molecular Biology |...
Numerous proteins were shown to be co-enriched with the CPE-binding claudins, but there are no indications (except for claudins ... The interaction of several claudins with Clostridium perfringens enterotoxin (CPE) has been exploited for an affinity-based ... Immunoblotting and mass spectrometry (MS) experiments demonstrate strong enrichment of the CPE-binding claudins -3, -4 and -7, ... CPE116-319 provides an efficient tool for single step enrichment of different claudins from cell lysates. ...
A peculiar internalization of claudins, tight junction-specific adhesion molecules, during the intercellular movement of...
The endocytosis of claudins was facilitated when the intercellular motility was upregulated by wounding the cellular sheets. ... The endocytosis of claudins was facilitated when the intercellular motility was upregulated by wounding the cellular sheets. ... The endocytosis of claudins was facilitated when the intercellular motility was upregulated by wounding the cellular sheets. ... The endocytosis of claudins was facilitated when the intercellular motility was upregulated by wounding the cellular sheets. ...
Transmembrane proteinsOccludinProteinsJunctional adhesionEpithelial cellsEndogenous claudinsBarrierPermeabilityAdhesionLocalizationSecond extracellular loopStrandsIsoformsTumorigenesisColorectal cancerExpressed in culturedProximalProteinTumor progressionExtracellular environmentCytoplasmCellsPhenotypePathogenesisRegulationRegulateMethodsIntercellularHumansRoleRolesBarriersHuman CancerAffinityFamilyTissuesBackboneBreast
Transmembrane proteins4
- Claudins are important transmembrane proteins in tight junctions. (biomedcentral.com)
- The major TJ proteins are the transmembrane proteins claudins, occludin, and junctional adhesion molecules (JAMs) [ 21 - 23 ]. (hindawi.com)
- TJs lay in the apical domain of epithelial cells and are mainly composed by transmembrane proteins such as occludin, claudins, JAMs, and tricellulin, that are associated with the cytoplasmic plaque formed by proteins from the MAGUK family, such as ZO-1/2/3, connecting TJ to the actin cytoskeleton, and cingulin and paracingulin connecting TJ to the microtubule network. (frontiersin.org)
- Yu, Alan 2007-05-22 00:00:00 Claudins are transmembrane proteins of the tight junction that determine and regulate paracellular ion permeability. (deepdyve.com)
Occludin10
- Much to our surprise, however, we have now also discovered several major TJ proteins (claudins 1 and 4, occludin, cingulin, symplekin, protein ZO-1) and TJ-related structures in specific positions of formations of epithelium-derived tissues that lack any lumen and do not border on luminal or body surfaces. (nih.gov)
- Claudins and occludin are integral membrane proteins localized at tight junctions, which are responsible for establishing and maintaining epithelial cell polarity. (biologists.org)
- We examined the relationship between Snail and the promoter activity of claudins and occludin. (biologists.org)
- When Snail was overexpressed in cultured mouse epithelial cells, EMT was induced with concomitant repression of the expression of claudins and occludin not only at the protein but also at the mRNA level. (biologists.org)
- We then isolated the promoters of genes encoding claudins and occludin, in which multiple E-boxes were identified. (biologists.org)
- Because the gene encoding E-cadherin was also reported to be repressed by Snail, we concluded that EMT was associated with the simultaneous repression of the genes encoding E-cadherin and claudins/occludin (i.e. the expression of adherens and tight junction adhesion molecules, respectively). (biologists.org)
- Both occludin and claudins bear four transmembrane domains but do not show any sequence similarity with each other. (biologists.org)
- Interestingly, other TJ components such as occludin, JAM and ZO-1 appeared to be dissociated from claudins before this endocytosis. (elsevier.com)
- Recent investigations have focused on tight junction proteins, belonging to the claudin family (claudins-1 to -27 in humans) and the newly defined group of TAMP (three proteins: occludin, Marvel-D2, and tricellulin). (wiley.com)
- Occludin and claudins in tight-junction strands: leading or supporting players? (ebi.ac.uk)
Proteins15
- Claudins are major integral membrane proteins of tight junctions. (mdpi.com)
- The results promote the development of recombinant cCPE-proteins and CPE-based peptidomimetics to modulate tight junctions for improved drug delivery or to treat tumors overexpressing claudins. (mdpi.com)
- Claudins are tight-junction membrane proteins that function as both pores and barriers in the paracellular pathway in epithelial cells. (asnjournals.org)
- Aldosterone and the with-no-lysine (WNK) proteins likely regulate claudins to fine-tune distal nephron salt transport. (asnjournals.org)
- 2 - 4 Claudins are members of a family of tight-junction membrane proteins that act simultaneously as paracellular pores and barriers and determine the selectivity to small ions and neutral solutes. (asnjournals.org)
- Claudins (CLDNs), belong to a large group of related adherent junction proteins, which are known to express characteristic patterns in inflammatory disorders. (celiac.com)
- Claudins are tight-junction proteins between epithelial cells that determine paracellular permeability characteristics of epithelia. (mysciencework.com)
- Claudins are key integral proteins of the tight junction. (biomedcentral.com)
- Claudins are integral membrane proteins and components of tight junction strands. (genecards.org)
- Most of the claudins (claudin-12 being the exception) have a C-terminal PDZ-binding motif that can interact with other PDZ domain proteins, such as scaffolding protein, ZO-1, -2 and -3 [ PMID: 24665401 ]. (ebi.ac.uk)
- The query remains set up extracellular loops of claudins may normally connect to the different parts of the extracellular milieu like the extracellular matrix proteins, especially since claudins have already been discovered localized at or near basolateral membranes of regular epithelium. (cylch.org)
- Members of several gene families are important for blastocyst formation, including claudins, zonal occludins (TJ proteins), occludins, jam proteins, cell polarity proteins, Na/K-ATPases and aquaporins. (biologists.org)
- Claudins are adhesion proteins localized at tight junctions (TJs). (aacrjournals.org)
- By contrast, in MDCK I cells, PMA treatment resulted in redistribution of claudins 1, 3, 4 and 5 from the TJ and in reorganization of the proteins into more insoluble complexes. (deepdyve.com)
- In this review the authors summarize the major novel findings of a dysfunctional skin barrier in AD, with emphasis on tight junction components, such as claudins and on proteins of the keratinocyte differentiation, such as filaggrin. (minervamedica.it)
Junctional adhesion2
- Tight junctions are composed of the junctional adhesion molecules, claudins (CLDNs) and occludins [ 3 - 5 ]. (pubmedcentralcanada.ca)
- The main components of tight junctions are claudins, occludins, and junctional adhesion molecules (JAMs). (thermofisher.com)
Epithelial cells4
- To elucidate a potential function for claudins outside of their traditional role in tight junctions, subcellular localization of claudin-4 was determined in normal mammary epithelial cells as well as breast and ovarian cancer cell lines and the effects of a claudin mimic peptide on cell motility were determined. (biomedcentral.com)
- These findings suggest that this peculiar internalization of claudins plays a crucial role in the remodeling of TJs, and that the fine regulation of this endocytosis is important for TJs to seal the intercellular space of epithelial cells that are moving against adjacent cells within cellular sheets. (elsevier.com)
- Results Claudins are found in cellular projections We first used immunostaining to localize claudin-4 in both normal mammary epithelial cells and breast tumor cells. (cylch.org)
- Our findings show that PKC activation targets in characteristic ways the expression patterns, destination, detergent solubility and phosphorylation state of claudins in epithelial cells with different capacities to form an epithelial barrier. (deepdyve.com)
Endogenous claudins3
- When TJs between two adjacent cells decreased in length during this remodeling, GFP-claudin-3 was frequently pinched off as a granular structure from GFP-positive TJs together with endogenous claudins. (elsevier.com)
- The effect of single amino acid substitutions of the second ECL of Cld5 were studied in cells expressing various other endogenous claudins except Cld5. (hu-berlin.de)
- Unlike in MDCK II cells, induction of claudin-8 in MDCK I cells (which did not affect levels of endogenous claudins) did not alter paracellular ion permeability. (deepdyve.com)
Barrier3
- The aim of this study was to characterize the hCMEC/D3 cell line, an in vitro model of the human Blood Brain Barrier (BBB) for the expression of brain endothelial specific claudins-3 and -12. (open.ac.uk)
- Although the structure and functions of the 27 different subtypes [ 1 ] of claudin are not fully understood, the tight junction barrier properties of claudins have been well characterized. (biomedcentral.com)
- Claudins create a barrier to paracellular permeability, and claudin-5 gene deletion is lethal because of loss of blood-brain barrier integrity ( 14 ). (diabetesjournals.org)
Permeability10
- In the kidney, claudins determine the permeability and selectivity of different nephron segments along the renal tubule. (asnjournals.org)
- It is widely believed that the specific set of claudins expressed by each nephron segment determines the unique paracellular permeability properties of that segment. (asnjournals.org)
- Effect of claudins 6 and 9 on paracellular permeability in MDC. (mysciencework.com)
- Expression of claudins 6 and 9 resulted in an increased transepithelial resistance, decreased chloride permeability, and decreased P(Na)/P(Cl) and P(HCO3)/P(Cl). (mysciencework.com)
- These findings constitute the first characterization of the permeability characteristics of claudins 6 and 9 in a cell model and may explain why the neonatal proximal tubule has lower permeability to chloride and higher resistance than the adult proximal tubule. (mysciencework.com)
- The C-terminal region of Clostridium perfringens enterotoxin (C-CPE) can bind to specific claudins, resulting in the disintegration of tight junctions (TJs) and an increase in the paracellular permeability across epithelial cell sheets. (rcsb.org)
- Claudins are major determinants of TJ permeability. (bireme.br)
- Claudin-4 was the first claudin whose involvement in the TJ permeability in cultured cells was directly demonstrated, but the permeability properties of individual claudins including claudin-4 are still incompletely clarified. (bireme.br)
- Our results suggest the need for further knockout analysis to reveal the permeability properties of individual claudins. (bireme.br)
- Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. (genecards.org)
Adhesion1
- Recent evidence shows that claudins, a large family (at least 24 members) of intercellular adhesion molecules, form the seal and its variable pore-like properties. (nih.gov)
Localization6
- Localization of claudins along the adult mammalian renal tubule. (asnjournals.org)
- The distribution of individual claudins was detected by immunoblotting, and their cell type and subcellular localization were determined by immunofluorescence on cryosections of rat liver, pancreas, stomach, and small and large intestine. (nih.gov)
- Among differences in the gut are a crypt-to-villus decrease in claudin 2, a highly restricted expression of claudin 4 to colonic surface cells, and the finding that some claudins can be junctional, lateral, or show a gradient in junctional vs. lateral localization along the crypt-to-villus surface axis. (nih.gov)
- The aim of the present study was to establish the protein expression and localization pattern of the other brain endothelial specific claudins-3 and -12 in the hCMEC/D3 cell line. (biomedcentral.com)
- We found that claudin-4 knockout has no apparent effect on the localization of other claudins and electrophysiological properties in MDCK II cells. (bireme.br)
- Claudin-4 knockout in addition to claudin-2 knockout slightly increased the localization of other claudins at TJs but showed no obvious effects on the electrophysiological properties in MDCK II cells. (bireme.br)
Second extracellular loop2
- The C-terminal region (cCPE) binds to the second extracellular loop of a subset of claudins. (mdpi.com)
- The second extracellular loop of claudins is able to interact with the extracellular environment to promote normal and tumor cell motility when it is not associated with tight junction structures. (biomedcentral.com)
Strands3
- Claudins are thought to polymerize to form continuous strands along the lateral membrane of one cell while the extracellular domains of claudins on adjacent cells bridge the paracellular space to interact with each other, much like the teeth of a zipper. (asnjournals.org)
- The claudin-19/C-CPE complex shows no density of a short extracellular helix that is critical for claudins to assemble into TJ strands. (rcsb.org)
- We examined the expression pattern of claudins, the major components of TJ strands, in these cells: claudin-1 and -4 were expressed both in MDCK I and II cells, whereas the expression of claudin-2 was restricted to MDCK II cells. (nih.gov)
Isoforms2
- We have previously described the presence of two claudin isoforms, claudins 6 and 9, in the neonatal proximal tubule and subsequent reduction of these claudins during postnatal maturation. (mysciencework.com)
- Most types of claudins have more than two isoforms, that have a distinguish size or function. (wikipedia.org)
Tumorigenesis1
- Although their dysregulation in cancer suggests that claudins play a role in tumorigenesis, the exact underlying mechanism remains unclear. (mdpi.com)
Colorectal cancer3
- Cell membrane staining intensity of all claudins was found significantly lower in colorectal cancer tissues when compared to paired normal mucosa (p = 0.001). (diva-portal.org)
- In normal mucosa, cytoplasm showed no staining for claudins in any patient, whereas in paired colorectal cancer tissues, significant cytoplasmic staining appeared both for claudin 1 (p = 0.04) and claudin 4 (p = 0.01). (diva-portal.org)
- Colorectal cancer cells showed dystopic cytoplasmic location of claudins. (diva-portal.org)
Expressed in cultured1
- This evidence comes from the study of claudins expressed in cultured epithelial cell models, genetically altered mice, and human mutants. (nih.gov)
Proximal2
- In the proximal tubule, claudins have a role in the bulk reabsorption of salt and water. (asnjournals.org)
- Celiac.com 03/15/2010 - A team of researchers recently set out to investigate mucosal expression of claudins 2, 3 and 4 in the proximal and distal parts of duodenum in children with celiac disease. (celiac.com)
Protein2
- Although claudins are well-known apical TJ protein, recent antibody-based research indicated that many claudins, including claudin-7, aren't only localized on the apical TJs but likewise have a solid basolateral membrane distribution in the epithelia of varied tissue [14C16]. (recob-tlse.org)
- Claudins are the largest and most important protein family within the TJ. (hu-berlin.de)
Tumor progression3
- The involvement of claudins in tumor progression was suggested by their important role in the migration, invasion and metastasis of cancer cells in a tissue-dependent manner. (mdpi.com)
- A potential function for claudins not localized within tight junction structures can also be supported by the observation that during tumor progression, where disruption and loss of tight junction structures is a hallmark characteristic, certain claudin subtypes are distinctly expressed. (biomedcentral.com)
- In recent years, many studies have shown that abnormality of claudins expression is implicated in the tumor progression. (bvsalud.org)
Extracellular environment2
- Conclusion The next extracellular loop of claudins can connect to the extracellular environment to market regular and tumor cell motility when it's not connected with limited junction constructions. (cylch.org)
- Using a little peptide that mimics a conserved series in the next extracellular loop of subset of claudin subtypes, including claudin-4 [28], we could LGX 818 (Encorafenib) actually determine that the next extracellular loop of non-tight junctional claudins is exposed to the extracellular environment in non-polarized cells and that interruption of this loops normal interactions inhibits cell motility. (cylch.org)
Cytoplasm1
- no information has been given on the recruitment of claudins from cytoplasm to tight junction. (frontiersin.org)
Cells10
- Recent studies have shown that they play a role in epithelial to mesenchymal transition (EMT), the formation of cancer stem cells or tumor-initiating cells (CSCs/TICs), and chemoresistance, suggesting that claudins are promising targets for the treatment of chemoresistant and recurrent tumors. (mdpi.com)
- hCMEC/D3 cells express claudins-3 and -12. (open.ac.uk)
- In the present study the role of human papillomavirus (HPV) 16 E7 oncoprotein on the sealing of TJs was investigated and also the expression level of claudins in mouse cervix and in epithelial Madin‑Darby Canine Kidney (MDCK) cells. (spandidos-publications.com)
- In MDCK cells the stable expression of E7 increased the space between adjacent cells and altered the architecture of the monolayers, induced the development of an acute peak of transepithelial electrical resistance accompanied by a reduced expression of claudins ‑1, ‑2 and ‑10, and an increase in claudin‑4. (spandidos-publications.com)
- We transfected claudins 6 and 9 into Madin-Darby canine kidney II (MDCK II) cells and performed electrophysiological studies to determine the resultant changes in physiological characteristics of the cells. (mysciencework.com)
- 001). Reactive mesothelial cells rarely expressed claudins. (mesothelioma-line.com)
- Although over expression of claudins is well documented in epithelial-derived cancer cells, the role of claudins in tumor promotion has received little attention. (biomedcentral.com)
- Turksen K. Claudins and cancer stem cells. (springer.com)
- In HT29 cells, claudins 1, 3, 4 and 5 and possibly claudin 2 were redistributed to apical cell-cell contacts after PKC activation and the amounts of claudins 1, 3 and 5, but not of claudin 2, were increased in cell lysates. (deepdyve.com)
- Claudins 1 and 4 were phosphorylated in both MDCK I and HT29 cells, but PKC-induced changes in claudin phosphorylation state were detected only in MDCK I cells. (deepdyve.com)
Phenotype1
- Our findings demonstrate that claudin overexpression studies measure the combined effect of alterations in both endogenous and exogenous claudins, thus explaining the dependence of the phenotype on the host cell line. (deepdyve.com)
Pathogenesis2
- It is likely that additional roles for claudins in the pathogenesis of other types of kidney diseases have yet to be uncovered. (asnjournals.org)
- The investigation of claudins promises to reveal novel fundamental insights into the pathogenesis of many diseases, including acute kidney injury, salt-sensitive hypertension and kidney stone disease. (kumc.edu)
Regulation1
- The critical role of epigenetic mechanisms in the regulation of claudin expression indicates the possible application of epigenetic therapy to target claudins. (mdpi.com)
Regulate1
- So through the repolarization of aminoacids could claudins selectively regulate the molecule transfer. (wikipedia.org)
Methods6
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- This site is hosted with help from this BlueHost review A Renewable shop Claudins: Methods to clear credits of different perspectives in( Nazis, j, folder, etc), with dead children, as telling the purposes and roads of each. (katrinacottagehousing.org)
Intercellular1
- The endocytosis of claudins was facilitated when the intercellular motility was upregulated by wounding the cellular sheets. (elsevier.com)
Humans1
- In humans, 24 claudins (claudin 1-24) have been identified. (ebi.ac.uk)
Role2
- A better understanding of the emerging role of claudins in CSC/TICs and chemoresistance may help to develop therapies against recurrent cancers. (mdpi.com)
- We analyzed the diagnostic role of claudins in effusion cytology in 325 effusions, including 218 ovarian, 49 breast, 15 cervical or endometrial, 10 gastrointestinal, and 8 lung adenocarcinomas and 25 malignant mesotheliomas (MMs). (mesothelioma-line.com)
Roles1
- Kwon, M.J. Emerging Roles of Claudins in Human Cancer. (mdpi.com)
Barriers1
- In the distal nephron, claudins need to form cation barriers and chloride pores to facilitate electrogenic sodium reabsorption and potassium and acid secretion. (asnjournals.org)
Human Cancer1
- Claudins in human cancer: a review. (springer.com)
Affinity2
Family1
- Paracellular transport occurs through tight junctions and is mediated by a family of channels called claudins. (kumc.edu)
Tissues2
Backbone1
- Claudins (Cld) form the structural backbone of TJs. (hu-berlin.de)
Breast2
- A recently identified claudin-low breast cancer subtype that is characterized by the enrichment of EMT and stem cell-like features is significantly associated with disease recurrence, underscoring the importance of claudins as predictors of tumor recurrence. (mdpi.com)
- Szász M. Claudins as prognostic factors of breast cancer. (springer.com)