Claudin 5. Medical search

A large family of transmembrane proteins found in TIGHT JUNCTIONS. They take part in the formation of paracellular barriers and pores that regulate paracellular permeability.

A ubiquitously-expressed claudin subtype that acts as a general barrier-forming protein in TIGHT JUNCTIONS. Elevated expression of claudin-3 is found in a variety of tumor cell types, suggesting its role as a therapeutic target for specific ANTINEOPLASTIC AGENTS.

An integral membrane protein that is localized to TIGHT JUNCTIONS, where it plays a role in controlling the paracellular permeability of polarized cells. Mutations in the gene for claudin-1 are associated with Neonatal Ichthyosis-Sclerosing Cholangitis (NISCH) Syndrome.

A claudin subtype that takes part in maintaining the barrier-forming property of TIGHT JUNCTIONS. Claudin-4 is found associated with CLAUDIN-8 in the KIDNEY COLLECTING DUCT where it may play a role in paracellular chloride ion reabsorption.

Cell-cell junctions that seal adjacent epithelial cells together, preventing the passage of most dissolved molecules from one side of the epithelial sheet to the other. (Alberts et al., Molecular Biology of the Cell, 2nd ed, p22)

A claudin subtype that is found localized to TIGHT JUNCTIONS in VASCULAR ENDOTHELIAL CELLS. The protein was initially identified as one of several proteins which are deleted in VELOCARDIOFACIAL SYNDROME and may play an important role in maintaining the integrity of the BLOOD-BRAIN BARRIER.

Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.

A MARVEL domain protein that plays an important role in the formation and regulation of the TIGHT JUNCTION paracellular permeability barrier.

A 195-kDa zonula occludens protein that is distinguished by the presence of a ZU5 domain at the C-terminal of the molecule.

A zonula occludens protein subtype found in epithelial cell junctions. Several isoforms of zonula occludens-2 protein exist due to use of alternative promoter regions and alternative mRNA splicings.

A claudin subtype that is associated with the formation of cation-selective channels and increased epithelial permeability. It is localized to the TIGHT JUNCTIONS of the PROXIMAL KIDNEY TUBULE and INTESTINAL EPITHELIUM.

A specialized barrier, in the TESTIS, between the interstitial BLOOD compartment and the adluminal compartment of the SEMINIFEROUS TUBULES. The barrier is formed by layers of cells from the VASCULAR ENDOTHELIUM of the capillary BLOOD VESSELS, to the SEMINIFEROUS EPITHELIUM of the seminiferous tubules. TIGHT JUNCTIONS form between adjacent SERTOLI CELLS, as well as between the ENDOTHELIAL CELLS.

Property of membranes and other structures to permit passage of light, heat, gases, liquids, metabolites, and mineral ions.

The resistance to the flow of either alternating or direct electrical current.

The technique of placing cells or tissue in a supporting medium so that thin sections can be cut using a microtome. The medium can be paraffin wax (PARAFFIN EMBEDDING) or plastics (PLASTIC EMBEDDING) such as epoxy resins.

A genus of pufferfish commonly used for research.

Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.

Excretion of abnormally high level of CALCIUM in the URINE, greater than 4 mg/kg/day.

An inherited renal disorder characterized by defective NaCl reabsorption in the convoluted DISTAL KIDNEY TUBULE leading to HYPOKALEMIA. In contrast with BARTTER SYNDROME, Gitelman syndrome includes hypomagnesemia and normocalcemic hypocalciuria, and is caused by mutations in the thiazide-sensitive SODIUM-POTASSIUM-CHLORIDE SYMPORTERS.

A condition characterized by calcification of the renal tissue itself. It is usually seen in distal RENAL TUBULAR ACIDOSIS with calcium deposition in the DISTAL KIDNEY TUBULES and the surrounding interstitium. Nephrocalcinosis causes RENAL INSUFFICIENCY.

A quality of cell membranes which permits the passage of solvents and solutes into and out of cells.

Human colonic ADENOCARCINOMA cells that are able to express differentiation features characteristic of mature intestinal cells, such as ENTEROCYTES. These cells are valuable in vitro tools for studies related to intestinal cell function and differentiation.

The U-shaped portion of the renal tubule in the KIDNEY MEDULLA, consisting of a descending limb and an ascending limb. It is situated between the PROXIMAL KIDNEY TUBULE and the DISTAL KIDNEY TUBULE.

Preparation for electron microscopy of minute replicas of exposed surfaces of the cell which have been ruptured in the frozen state. The specimen is frozen, then cleaved under high vacuum at the same temperature. The exposed surface is shadowed with carbon and platinum and coated with carbon to obtain a carbon replica.

Cells of epithelial origin possessing specialized sensory functions. They include cells that are found in the TASTE BUDS; OLFACTORY MUCOSA; COCHLEA; and NEUROEPITHELIAL BODIES.

One or more layers of EPITHELIAL CELLS, supported by the basal lamina, which covers the inner or outer surfaces of the body.

Paired respiratory organs of fishes and some amphibians that are analogous to lungs. They are richly supplied with blood vessels by which oxygen and carbon dioxide are exchanged directly with the environment.

The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)

Anchoring points where the CYTOSKELETON of neighboring cells are connected to each other. They are composed of specialized areas of the plasma membrane where bundles of the ACTIN CYTOSKELETON attach to the membrane through the transmembrane linkers, CADHERINS, which in turn attach through their extracellular domains to cadherins in the neighboring cell membranes. In sheets of cells, they form into adhesion belts (zonula adherens) that go all the way around a cell.

Supporting cells projecting inward from the basement membrane of SEMINIFEROUS TUBULES. They surround and nourish the developing male germ cells and secrete ANDROGEN-BINDING PROTEIN and hormones such as ANTI-MULLERIAN HORMONE. The tight junctions of Sertoli cells with the SPERMATOGONIA and SPERMATOCYTES provide a BLOOD-TESTIS BARRIER.

A usually benign glandular tumor composed of oxyphil cells, large cells with small irregular nuclei and dense acidophilic granules due to the presence of abundant MITOCHONDRIA. Oxyphil cells, also known as oncocytes, are found in oncocytomas of the kidney, salivary glands, and endocrine glands. In the thyroid gland, oxyphil cells are known as Hurthle cells and Askanazy cells.

Histochemical localization of immunoreactive substances using labeled antibodies as reagents.

Direct contact of a cell with a neighboring cell. Most such junctions are too small to be resolved by light microscopy, but they can be visualized by conventional or freeze-fracture electron microscopy, both of which show that the interacting CELL MEMBRANE and often the underlying CYTOPLASM and the intervening EXTRACELLULAR SPACE are highly specialized in these regions. (From Alberts et al., Molecular Biology of the Cell, 2d ed, p792)

Established cell cultures that have the potential to propagate indefinitely.

Different forms of a protein that may be produced from different GENES, or from the same gene by ALTERNATIVE SPLICING.

The artificial induction of GENE SILENCING by the use of RNA INTERFERENCE to reduce the expression of a specific gene. It includes the use of DOUBLE-STRANDED RNA, such as SMALL INTERFERING RNA and RNA containing HAIRPIN LOOP SEQUENCE, and ANTI-SENSE OLIGONUCLEOTIDES.

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism.

Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.

A form of fluorescent antibody technique commonly used to detect serum antibodies and immune complexes in tissues and microorganisms in specimens from patients with infectious diseases. The technique involves formation of an antigen-antibody complex which is labeled with fluorescein-conjugated anti-immunoglobulin antibody. (From Bennington, Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)

Degree of saltiness, which is largely the OSMOLAR CONCENTRATION of SODIUM CHLORIDE plus any other SALTS present. It is an ecological factor of considerable importance, influencing the types of organisms that live in an ENVIRONMENT.

The simultaneous analysis of multiple samples of TISSUES or CELLS from BIOPSY or in vitro culture that have been arranged in an array format on slides or microchips.

The most common etiologic agent of GAS GANGRENE. It is differentiable into several distinct types based on the distribution of twelve different toxins.

A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

A general term for the complete or partial loss of the ability to hear from one or both ears.

RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.

Lining of the INTESTINES, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. In the SMALL INTESTINE, the mucosa is characterized by a series of folds and abundance of absorptive cells (ENTEROCYTES) with MICROVILLI.

The part of the inner ear (LABYRINTH) that is concerned with hearing. It forms the anterior part of the labyrinth, as a snail-like structure that is situated almost horizontally anterior to the VESTIBULAR LABYRINTH.

Phenotypic changes of EPITHELIAL CELLS to MESENCHYME type, which increase cell mobility critical in many developmental processes such as NEURAL TUBE development. NEOPLASM METASTASIS and DISEASE PROGRESSION may also induce this transition.

The portion of renal tubule that begins from the enlarged segment of the ascending limb of the LOOP OF HENLE. It reenters the KIDNEY CORTEX and forms the convoluted segments of the distal tubule.

Substances that are toxic to the intestinal tract causing vomiting, diarrhea, etc.; most common enterotoxins are produced by bacteria.

Male germ cells derived from SPERMATOGONIA. The euploid primary spermatocytes undergo MEIOSIS and give rise to the haploid secondary spermatocytes which in turn give rise to SPERMATIDS.

Membrane-limited structures derived from the plasma membrane or various intracellular membranes which function in storage, transport or metabolism.

A malignant neoplasm arising from tenosynovial tissue of the joints and in synovial cells of tendons and bursae. The legs are the most common site, but the tumor can occur in the abdominal wall and other trunk muscles. There are two recognized types: the monophasic (characterized by sheaths of monotonous spindle cells) and the biphasic (characterized by slit-like spaces or clefts within the tumor, lined by cuboidal or tall columnar epithelial cells). These sarcomas occur most commonly in the second and fourth decades of life. (From Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1363)

A genetic rearrangement through loss of segments of DNA or RNA, bringing sequences which are normally separated into close proximity. This deletion may be detected using cytogenetic techniques and can also be inferred from the phenotype, indicating a deletion at one specific locus.

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.

Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.

The mucous membrane lining the RESPIRATORY TRACT, including the NASAL CAVITY; the LARYNX; the TRACHEA; and the BRONCHI tree. The respiratory mucosa consists of various types of epithelial cells ranging from ciliated columnar to simple squamous, mucous GOBLET CELLS, and glands containing both mucous and serous cells.

Carcinoma that arises from the PANCREATIC DUCTS. It accounts for the majority of cancers derived from the PANCREAS.

Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.

The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.

An EPITHELIUM with MUCUS-secreting cells, such as GOBLET CELLS. It forms the lining of many body cavities, such as the DIGESTIVE TRACT, the RESPIRATORY TRACT, and the reproductive tract. Mucosa, rich in blood and lymph vessels, comprises an inner epithelium, a middle layer (lamina propria) of loose CONNECTIVE TISSUE, and an outer layer (muscularis mucosae) of SMOOTH MUSCLE CELLS that separates the mucosa from submucosa.

Stratified squamous epithelium that covers the outer surface of the CORNEA. It is smooth and contains many free nerve endings.

The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.

The physical or physiological processes by which substances, tissue, cells, etc. take up or take in other substances or energy.

Microscopy of specimens stained with fluorescent dye (usually fluorescein isothiocyanate) or of naturally fluorescent materials, which emit light when exposed to ultraviolet or blue light. Immunofluorescence microscopy utilizes antibodies that are labeled with fluorescent dye.

The sequential location of genes on a chromosome.

Specialized non-fenestrated tightly-joined ENDOTHELIAL CELLS with TIGHT JUNCTIONS that form a transport barrier for certain substances between the cerebral capillaries and the BRAIN tissue.

The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.

Small polyhedral outpouchings along the walls of the alveolar sacs, alveolar ducts and terminal bronchioles through the walls of which gas exchange between alveolar air and pulmonary capillary blood takes place.

Proteins obtained from the ZEBRAFISH. Many of the proteins in this species have been the subject of studies involving basic embryological development (EMBRYOLOGY).

Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.

Calcium-dependent cell adhesion proteins. They are important in the formation of ADHERENS JUNCTIONS between cells. Cadherins are classified by their distinct immunological and tissue specificities, either by letters (E- for epithelial, N- for neural, and P- for placental cadherins) or by numbers (cadherin-12 or N-cadherin 2 for brain-cadherin). Cadherins promote cell adhesion via a homophilic mechanism as in the construction of tissues and of the whole animal body.

A carcinoma discovered by Dr. Margaret R. Lewis of the Wistar Institute in 1951. This tumor originated spontaneously as a carcinoma of the lung of a C57BL mouse. The tumor does not appear to be grossly hemorrhagic and the majority of the tumor tissue is a semifirm homogeneous mass. (From Cancer Chemother Rep 2 1972 Nov;(3)1:325) It is also called 3LL and LLC and is used as a transplantable malignancy.

Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.

An exotic species of the family CYPRINIDAE, originally from Asia, that has been introduced in North America. They are used in embryological studies and to study the effects of certain chemicals on development.

The process of moving proteins from one cellular compartment (including extracellular) to another by various sorting and transport mechanisms such as gated transport, protein translocation, and vesicular transport.

A light microscopic technique in which only a small spot is illuminated and observed at a time. An image is constructed through point-by-point scanning of the field in this manner. Light sources may be conventional or laser, and fluorescence or transmitted observations are possible.

A cell line derived from cultured tumor cells.

Interruption or suppression of the expression of a gene at transcriptional or translational levels.

Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.

The process of germ cell development in the male from the primordial germ cells, through SPERMATOGONIA; SPERMATOCYTES; SPERMATIDS; to the mature haploid SPERMATOZOA.

Immunologic method used for detecting or quantifying immunoreactive substances. The substance is identified by first immobilizing it by blotting onto a membrane and then tagging it with labeled antibodies.

The pattern of GENE EXPRESSION at the level of genetic transcription in a specific organism or under specific circumstances in specific cells.

Orientation of intracellular structures especially with respect to the apical and basolateral domains of the plasma membrane. Polarized cells must direct proteins from the Golgi apparatus to the appropriate domain since tight junctions prevent proteins from diffusing between the two domains.

The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.

A set of genes descended by duplication and variation from some ancestral gene. Such genes may be clustered together on the same chromosome or dispersed on different chromosomes. Examples of multigene families include those that encode the hemoglobins, immunoglobulins, histocompatibility antigens, actins, tubulins, keratins, collagens, heat shock proteins, salivary glue proteins, chorion proteins, cuticle proteins, yolk proteins, and phaseolins, as well as histones, ribosomal RNA, and transfer RNA genes. The latter three are examples of reiterated genes, where hundreds of identical genes are present in a tandem array. (King & Stanfield, A Dictionary of Genetics, 4th ed)

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.

Refers to animals in the period of time just after birth.

Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.

Methods used for detecting the amplified DNA products from the polymerase chain reaction as they accumulate instead of at the end of the reaction.

The relationships of groups of organisms as reflected by their genetic makeup.

A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.

Highly specialized EPITHELIAL CELLS that line the HEART; BLOOD VESSELS; and lymph vessels, forming the ENDOTHELIUM. They are polygonal in shape and joined together by TIGHT JUNCTIONS. The tight junctions allow for variable permeability to specific macromolecules that are transported across the endothelial layer.

The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.

Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.

Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.

MAMMARY GLANDS in the non-human MAMMALS.

A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)

Surface ligands, usually glycoproteins, that mediate cell-to-cell adhesion. Their functions include the assembly and interconnection of various vertebrate systems, as well as maintenance of tissue integration, wound healing, morphogenic movements, cellular migrations, and metastasis.

A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.

Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.

Tumors or cancer of the human BREAST.

A set of statistical methods used to group variables or observations into strongly inter-related subgroups. In epidemiology, it may be used to analyze a closely grouped series of events or cases of disease or other health-related phenomenon with well-defined distribution patterns in relation to time or place or both.

Adherence of cells to surfaces or to other cells.

The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.

Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.

A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.

Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).

All of the processes involved in increasing CELL NUMBER including CELL DIVISION.

Laboratory tests used to evaluate how well the kidneys are working through examination of blood and urine.

Proteins prepared by recombinant DNA technology.

Endothelial claudin: claudin-5/TMVCF constitutes tight junction strands in endothelial cells. (1/124)

Tight junctions (TJs) in endothelial cells are thought to determine vascular permeability. Recently, claudin-1 to -15 were identified as major components of TJ strands. Among these, claudin-5 (also called transmembrane protein deleted in velo-cardio-facial syndrome [TMVCF]) was expressed ubiquitously, even in organs lacking epithelial tissues, suggesting the possible involvement of this claudin species in endothelial TJs. We then obtained a claudin-6-specific polyclonal antibody and a polyclonal antibody that recognized both claudin-5/TMVCF and claudin-6. In the brain and lung, immunofluorescence microscopy with these polyclonal antibodies showed that claudin-5/TMVCF was exclusively concentrated at cell-cell borders of endothelial cells of all segments of blood vessels, but not at those of epithelial cells. Immunoreplica electron microscopy revealed that claudin-5/TMVCF was a component of TJ strands. In contrast, in the kidney, the claudin-5/TMVCF signal was restricted to endothelial cells of arteries, but was undetectable in those of veins and capillaries. In addition, in all other tissues we examined, claudin-5/TMVCF was specifically detected in endothelial cells of some segments of blood vessels, but not in epithelial cells. Furthermore, when claudin-5/TMVCF cDNA was introduced into mouse L fibroblasts, TJ strands were reconstituted that resembled those in endothelial cells in vivo, i.e., the extracellular face-associated TJs. These findings indicated that claudin-5/TMVCF is an endothelial cell-specific component of TJ strands. (+info)

Claudin promotes activation of pro-matrix metalloproteinase-2 mediated by membrane-type matrix metalloproteinases. (2/124)

Genes associated with regulation of membrane-type matrix metalloproteinase-1 (MT1-MMP)-mediated pro-MMP-2 processing were screened in 293T cells by a newly developed expression cloning method. One of the gene products, which promoted processing of pro-MMP-2 by MT1-MMP was claudin-5, a major component of endothelial tight junctions. Expression of claudin-5 not only replaced TIMP-2 in pro-MMP-2 activation by MT1-MMP but also promoted activation of pro-MMP-2 mediated by all MT-MMPs and MT1-MMP mutants lacking the transmembrane domain (DeltaMT1-MMP). A carboxyl-terminal deletion mutant of pro-MMP-2 (proDeltaMMP-2) was processed to an intermediate form by MT1-MMP in 293T cells and was further converted to an activated form by introduction of claudin-5. In contrast to the stimulatory effect of TIMP-2 on pro-MMP-2 activation by MT1-MMP, activation of pro-MMP-2 by DeltaMT1-MMP in the presence of claudin-5 and proDeltaMMP-2 processing by MT1-MMP were both inversely repressed by expression of exogenous TIMP-2. These results suggest that TIMP-2 is not involved in cluadin-5-induced pro-MMP-2 activation by MT-MMPs. Stimulation of MT-MMP-mediated pro-MMP-2 activation was also observed with other claudin family members, claudin-1, claudin-2, and claudin-3. Amino acid substitutions or deletions in ectodomain of claudin-1 abolished stimulatory effect. Direct interaction of claudin-1 with MT1-MMP and MMP-2 was demonstrated by immunoprecipitation analysis. MT1-MMP was co-localized with claudin-1 not only at cell-cell borders, but also at other parts of the cells. TIMP-2 enhanced cell surface localization of MMP-2 mediated by MT1-MMP, and claudin-1 also stimulated it. These results suggest that claudin recruits all MT-MMPs and pro-MMP-2 on the cell surface to achieve elevated focal concentrations and, consequently, enhances activation of pro-MMP-2. (+info)

The renal segmental distribution of claudins changes with development. (3/124)

BACKGROUND: Permeability properties of mammalian nephron are tuned during postnatal maturation. The transepithelial electrical resistance (TER) and complexity of tight junctions (TJs) vary along the different tubular segments, suggesting that the molecules constituting this structure change. We studied the differential expression of occludin and several claudins in isolated renal tubules from newborn and adult rabbits. METHODS: Isolated renal tubules from newborn and adult rabbits were processed for occludin, claudin-1 and claudin-2 immunofluorescence, and Western blot detection of claudin-1 and -2. Claudin-5 was detected in whole kidney frozen sections. RT-PCR from isolated tubules was performed for claudins-1 to -8. RESULTS: Immunofluorescence revealed that occludin, claudin-1 and -2 were present at the cell boundaries at the neonatal stage of development. Claudin-1 was detected in the tighter segments of the nephron (distal and collecting duct), while claudin-2 was found in the leaky portions (proximal). Claudin 5 was found in the kidney vasculature. PCR amplification revealed the presence of claudins-1 to -4 in tubules of newborns. In adults, claudins-1, -2 and -4 were present in proximal, Henle's loop and collecting segments; claudin-3 was in proximal and collecting tubules, while claudins-5 and -6 were absent from all tubular portions. Claudin-7 was restricted to proximal tubules, while claudin-8 was present in proximal and Henle's segments. CONCLUSIONS: The pattern of occludin distribution is present from the neonatal age. Claudins-7 and -8 are up-regulated after birth. Each tubular segment expresses a peculiar set of claudins that might be responsible for the permeability properties of their TJs. (+info)

Prolonged fluid shear stress induces a distinct set of endothelial cell genes, most specifically lung Kruppel-like factor (KLF2). (4/124)

The endothelium expresses a large repertoire of genes under apparent transcriptional control of biomechanical forces, many of which are neither cell-type nor flow specific. We set out to identify genes that are uniquely flow responsive in human vascular endothelial cells. Transcriptional profiling using commercial DNA microarrays identified 12 of 18 000 genes that were modulated at least 5-fold after 24 hours of steady laminar flow (25 dyne/cm(2)). After a 7-day exposure to unidirectional pulsatile flow (19 +/- 12 dyne/cm(2)), only 3 of 12 remained elevated at least 5-fold. A custom microarray of ~300 vascular cell-related gene fragments was constructed, and expression analysis revealed that many flow-induced genes are also induced by at least one of the following agents: tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), transforming growth factor-beta, vascular endothelial growth factor, or thrombin, indicating a more general role in adaptive or stress responses. Most flow-induced genes were also induced by TNF-alpha but not IL-1beta, suggesting the involvement of reactive oxygen species. A limited panel of genes that are unique for flow-exposed cultures was identified, including lung Kruppel-like factor (LKLF/KLF2) and cytochrome P450 1B1 (CYP1B1). In marked contrast, both these genes were substantially repressed by TNF-alpha. LKLF but not CYP1B1 mRNA was detected exclusively in the vascular endothelium of healthy human aorta by in situ hybridization and appeared to be flow regulated. To date LKLF is the first endothelial transcription factor that is uniquely induced by flow and might therefore be at the molecular basis of the physiological healthy, flow-exposed state of the endothelial cell. (+info)

Distinct claudins and associated PDZ proteins form different autotypic tight junctions in myelinating Schwann cells. (5/124)

The apposed membranes of myelinating Schwann cells are joined by several types of junctional specializations known as autotypic or reflexive junctions. These include tight, gap, and adherens junctions, all of which are found in regions of noncompact myelin: the paranodal loops, incisures of Schmidt-Lanterman, and mesaxons. The molecular components of autotypic tight junctions have not been established. Here we report that two homologues of Discs Lost-multi PDZ domain protein (MUPP)1, and Pals-associated tight junction protein (PATJ), are differentially localized in myelinating Schwann cells and associated with different claudins. PATJ is mainly found at the paranodal loops, where it colocalized with claudin-1. MUPP1 and claudin-5 colocalized in the incisures, and the COOH-terminal region of claudin-5 interacts with MUPP1 in a PSD-95/Disc Large/zona occludens (ZO)-1 (PDZ)-dependent manner. In developing nerves, claudin-5 and MUPP1 appear together in incisures during the first postnatal week, suggesting that they coassemble during myelination. Finally, we show that the incisures also contain four other PDZ proteins that are found in epithelial tight junctions, including three membrane-associated guanylate-kinase proteins (membrane-associated guanylate-kinase inverted-2, ZO-1, and ZO-2) and the adaptor protein Par-3. The presence of these different tight junction proteins in regions of noncompact myelin may be required to maintain the intricate cytoarchitecture of myelinating Schwann cells. (+info)

Holey barrier: claudins and the regulation of brain endothelial permeability. (6/124)

Endothelial tight junctions (TJs)* are an important functional part of the blood-brain barrier (BBB). In this issue, Nitta et al. (2003) demonstrate that claudin-5, a transmembrane protein of TJs, is a critical determinant of BBB permeability in mice. Unexpectedly, knockout of claudin-5 did not result in a general breakdown of TJs but in a selective increase in paracellular permeability of small molecules. This suggests that the BBB can be manipulated to allow selective diffusion of small molecules and makes claudin-5 a possible target for the development of drugs for this purpose. (+info)

Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice. (7/124)

Tight junctions are well-developed between adjacent endothelial cells of blood vessels in the central nervous system, and play a central role in establishing the blood-brain barrier (BBB). Claudin-5 is a major cell adhesion molecule of tight junctions in brain endothelial cells. To examine its possible involvement in the BBB, claudin-5-deficient mice were generated. In the brains of these mice, the development and morphology of blood vessels were not altered, showing no bleeding or edema. However, tracer experiments and magnetic resonance imaging revealed that in these mice, the BBB against small molecules (<800 D), but not larger molecules, was selectively affected. This unexpected finding (i.e., the size-selective loosening of the BBB) not only provides new insight into the basic molecular physiology of BBB but also opens a new way to deliver potential drugs across the BBB into the central nervous system. (+info)

Role of claudin interactions in airway tight junctional permeability. (8/124)

Airway epithelial tight junctions (TJs) serve to separate the external and internal environments of the lung. However, the members of the claudin family that mediate this function have not been fully delineated. We characterized the claudin expression in normal airways removed from human donors during lung transplantation and determined the contribution of each claudin to airway barrier function. Stable cell lines in NIH/3T3 and human airway (IB3.1) cells were constructed expressing the claudin components found in the human airway, claudin-1, -3, or -5. The effects of claudin expression on transepithelial resistance, permeability coefficients, and claudin-claudin interactions were assessed. Claudin-1 and -3 decreased solute permeability, whereas claudin-5 increased permeability. We also detected oligomerization of claudin-5 in cell lines and in freshly excised human airways. Coimmunoprecipitation studies revealed heterophilic interactions between claudin species in both cell lines and human airway epithelium. These suggest that airway TJs are regulated by claudinclaudin interactions that confer the selectivity of the junction. (+info)

The name claudin comes from Latin word claudere ("to close"), suggesting the barrier role of these proteins. A recent review ... A Chimeric Claudin was synthesized to help enhance the understanding of both the structure and function of the tight junction. ... All human claudins (with the exception of Claudin 12) have domains that let them bind to PDZ domains of scaffold proteins. The ... There are 23 genes found in the human genome for claudin proteins and there are 27 transmembrane domains across mammals. The ...

https://en.wikipedia.org/wiki/Claudin

Ernstson, K.; Claudin, F.; Schüssler, U.; Hradil, K. (2002). "The mid-Tertiary Azuara and Rubielos de la Cérida paired impact ... EDEIS Expert Database on Earth Impact Structures Archived July 27, 2011, at the Wayback Machine Ernstson, K., Claudin, F., ... 11: 5-65. Stöffler, D.; Langenhorst, F. (1994). "Shock metamorphism of quartz in nature and experiment: I. Basic observation ...

https://en.wikipedia.org/wiki/Azuara_impact_structure

over 1050 citations) Bouchaud, J.-P.; Claudin, P.; Levine, D.; Otto, M. (2001). "Force chain splitting in granular materials: A ... 73 (5): 644-647. Bibcode:1994PhRvL..73..644Z. doi:10.1103/PhysRevLett.73.644. PMID 10057501. (over 350 citations) Lacasse, ... 5): 051302. arXiv:cond-mat/0105071. Bibcode:2001PhRvE..64e1302S. doi:10.1103/PhysRevE.64.051302. PMID 11735913. S2CID 32482459 ... 5): 051307. Bibcode:2002PhRvE..65e1307S. doi:10.1103/PhysRevE.65.051307. PMID 12059551. Kurchan, Jorge; Levine, Dov (2011). " ...

https://en.wikipedia.org/wiki/Dov_Levine

In mice, Claudin-5 loss during development is lethal and results in size-selective loosening of the BBB. The blood-brain ... February 2018). "claudin 5". Biology Open. 7 (2): bio030494. doi:10.1242/bio.030494. PMC 5861362. PMID 29437557. Abbott NJ, ... May 2003). "Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice". The Journal of Cell Biology. 161 ... such as Claudin-5), junctional adhesion molecule (such as JAM-A). Each of these tight junction proteins is stabilized to the ...

https://en.wikipedia.org/wiki/Blood–brain_barrier

Ernstson, K.; Claudin, F.; Schüssler, U.; Hradil, K. (2002). "The mid-Tertiary Azuara and Rubielos de la Cérida paired impact ... Retrieved 5 April 2017. Kenny, G.G.; O'Sullivan, G.J.; Alexander, S.; Simms, M.J.; Chew, D.M.; Kamber, B.S. (2019). "On the ... 41 (5): 749-771. Povenmire, H.; Burrer, B.; Cornec, J.H.; Harris, R.S. (2012). "The New Central American Tektite Strewn Field ... 11: 5-65. World's largest asteroid impact zone found in Australia: Meteorite broke in two, leaving two craters each 200 km ...

https://en.wikipedia.org/wiki/List_of_possible_impact_structures_on_Earth

"Entrez Gene: CLDN4 claudin 4". Ohta Y, Sasaki Y, Saito M, Kushima M, Takimoto M, Shiokawa A, Ota H (2013). "Claudin-4 as a ... Claudin 4, also known as CLDN4, is a protein which in humans is encoded by the CLDN4 gene. It belongs to the group of claudins ... Claudin 4 can also be used as a marker for distinguishing malignant mesothelioma from lung cancer and uterine serous carcinoma ... Ohta Y, Sasaki Y, Saito M, Kushima M, Takimoto M, Shiokawa A, Ota H (2013). "Claudin-4 as a marker for distinguishing malignant ...

https://en.wikipedia.org/wiki/CLDN4

Claudin-14 is a protein that in humans is encoded by the CLDN14 gene. It belongs to a related family of proteins called ... "Entrez Gene: CLDN14 claudin 14". Baker M, Reynolds LE, Robinson SD, Lees DM, Parsons M, Elia G, et al. (2013). "Stromal ... Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): ... Sticky cells, blood vessels and cancer - the paradox of Claudin-14 - Marianne Baker, Cancer Research UK Science Update blog, 14 ...

https://en.wikipedia.org/wiki/CLDN14

"Entrez Gene: CLDN1 claudin 1". Coyne CB, Gambling TM, Boucher RC, Carson JL, Johnson LG (Nov 2003). "Role of claudin ... Claudin-1 is a protein that in humans is encoded by the CLDN1 gene. It belongs to the group of claudins. Tight junctions ... The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight ... Miyamori H, Takino T, Kobayashi Y, Tokai H, Itoh Y, Seiki M, Sato H (2001). "Claudin promotes activation of pro-matrix ...

https://en.wikipedia.org/wiki/CLDN1

Claudin 3, also known as CLDN3, is a protein which in humans is encoded by the CLDN3 gene. It is a member of the claudin ... "Entrez Gene: CLDN3 claudin 3". Coyne CB, Gambling TM, Boucher RC, Carson JL, Johnson LG (Nov 2003). "Role of claudin ... "Expression of Clostridium perfringens enterotoxin receptors claudin-3 and claudin-4 in prostate cancer epithelium". Cancer Res ... The protein encoded by this intron-less gene, a member of the claudin family, is an integral membrane protein and a component ...

https://en.wikipedia.org/wiki/CLDN3

Claudin-17 is a protein that in humans is encoded by the CLDN17 gene. It belongs to the group of claudins; claudins are cell- ... Claudin-17 Deficiency in Mice Results in Kidney Injury Due to Electrolyte Imbalance and Oxidative Stress. Cells. 2022 May 29;11 ... "Entrez Gene: CLDN17 claudin 17". Adil, MS; Narayanan, SP; Somanath, PR (2021). "Cell-cell junctions: structure and regulation ... Krug SM, Günzel D, Conrad MP, Rosenthal R, Fromm A, Amasheh S, Schulzke JD, Fromm M (2012). "Claudin-17 forms tight junction ...

https://en.wikipedia.org/wiki/CLDN17

Claudin-5 is a protein that in humans is encoded by the CLDN5 gene. It belongs to the group of claudins. This gene encodes a ... "Entrez Gene: CLDN5 claudin 5 (transmembrane protein deleted in velocardiofacial syndrome)". Coyne CB, Gambling TM, Boucher RC, ... Kojima S, Rahner C, Peng S, Rizzolo LJ (2002). "Claudin 5 is transiently expressed during the development of the retinal ... Tsukita S, Furuse M (2002). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): ...

https://en.wikipedia.org/wiki/CLDN5

"Entrez Gene: CLDN9 claudin 9". Higashi AY, Higashi T, Furuse K, Ozeki K, Furuse M, Chiba H (Nov 2021). "Claudin-9 constitutes ... 2007). "Claudin-6 and claudin-9 function as additional coreceptors for hepatitis C virus". J. Virol. 81 (22): 12465-71. doi: ... Claudin-9 is a protein that in humans is encoded by the CLDN9 gene. It belongs to the group of claudins. This gene is expressed ... Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): ...

https://en.wikipedia.org/wiki/CLDN9

It caused by mutations in the Claudin 1 gene. Ichthyosis prematurity syndrome List of cutaneous conditions Rapini, Ronald P.; ... Only 5 cases from 3 families worldwide have been described in medical literature. ...

https://en.wikipedia.org/wiki/Neonatal_ichthyosis–sclerosing_cholangitis_syndrome

Claudin-22 is a protein that in humans is encoded by the CLDN22 gene. It belongs to the group of claudins. GRCh38: Ensembl ... "Entrez Gene: CLDN22 claudin 22". Human CLDN22 genome location and CLDN22 gene details page in the UCSC Genome Browser. González ... Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): ... Heiskala M, Peterson PA, Yang Y (2001). "The roles of claudin superfamily proteins in paracellular transport". Traffic. 2 (2): ...

https://en.wikipedia.org/wiki/CLDN22

Claudin-11 is a protein that in humans is encoded by the CLDN11 gene. It belongs to the group of claudins and was the first ... "Entrez Gene: CLDN11 claudin 11 (oligodendrocyte transmembrane protein)". Gow A, Southwood CM, Li JS, Pariali M, Riordan GP, ... The protein encoded by this gene belongs to the claudin family of tight junction associated proteins and is a major component ... Tiwari-Woodruff SK, Buznikov AG, Vu TQ, Micevych PE, Chen K, Kornblum HI, Bronstein JM (April 2001). "OSP/claudin-11 forms a ...

https://en.wikipedia.org/wiki/CLDN11

"Stalin and the Second World War" - Fernando Claudin 11. "The First Breach: The Excommunication of Yugoslavia" - Josip Tito 12 ... Isaac Deutscher 5. "Marxism and Primitive Magic - ibid. 6. "Trotsky's Interpretation of Stalinism" - Perry Anderson 7. "Was ...

https://en.wikipedia.org/wiki/The_Stalinist_Legacy

"Entrez Gene: CLDN18 claudin 18". Niimi T, Nagashima K, Ward JM, et al. (2001). "claudin-18, a Novel Downstream Target Gene for ... Claudin 18.2) is abundant in gastric tumors. Experimental antibody IMAB362 targets Claudin 18.2 to help treat gastric cancers. ... Claudin-18 is a protein that in humans is encoded by the CLDN18 gene. It belongs to the group of claudins. CLDN18 belongs to ... Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): ...

https://en.wikipedia.org/wiki/CLDN18

Claudin-19 is a protein that in humans is encoded by the CLDN19 gene. It belongs to the group of claudins. Claudin-19 has been ... "Entrez Gene: CLDN19 claudin 19". Naeem, M.; Hussain, S.; Akhtar, N. (2011). "Mutation in the Tight-Junction Gene Claudin 19 ( ... 2006). "Kidney claudin-19: localization in distal tubules and collecting ducts and dysregulation in polycystic renal disease". ... Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): ...

https://en.wikipedia.org/wiki/CLDN19

Claudin-15 is a protein that in humans is encoded by the CLDN15 gene. It belongs to the group of claudins. Among its related ... "Entrez Gene: CLDN15 claudin 15". Database, GeneCards Human Gene. "CLDN15 Gene - GeneCards , CLD15 Protein , CLD15 Antibody". ... Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): ... Heiskala M, Peterson PA, Yang Y (2001). "The roles of claudin superfamily proteins in paracellular transport". Traffic. 2 (2): ...

https://en.wikipedia.org/wiki/CLDN15

Claudin-16 is a protein that in humans is encoded by the CLDN16 gene. It belongs to the group of claudins. Tight junctions ... The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight ... 2004). "A Novel Claudin 16 Mutation Associated with Childhood Hypercalciuria Abolishes Binding to ZO-1 and Results in Lysosomal ... "Entrez Gene: CLDN16 claudin 16". "Salmonella infection data for Cldn16". Wellcome Trust Sanger Institute. "Citrobacter ...

https://en.wikipedia.org/wiki/CLDN16

Claudin-2 is a protein that in humans is encoded by the CLDN2 gene. It belongs to the group of claudins. Members of the claudin ... Claudin-2 is expressed in cation-leaky epithelia such as that of the kidney proximal tubule. Mice that are deficient in claudin ... "Entrez Gene: CLDN2 claudin 2". Muto, S.; Hata, M.; Taniguchi, J.; Tsuruoka, S.; Moriwaki, K.; Saitou, M.; Furuse, K.; Sasaki, H ... 1998). "Claudin-1 and -2: Novel Integral Membrane Proteins Localizing at Tight Junctions with No Sequence Similarity to ...

https://en.wikipedia.org/wiki/CLDN2

Cates, M. E.; Wittmer, J. P.; Bouchaud, J.-P.; Claudin, P. (31 August 1998). "Jamming, Force Chains, and Fragile Matter". ... Pham, K. N. (5 April 2002). "Multiple Glassy States in a Simple Model System". Science. American Association for the ... Cates was born on 5 May 1961. He read Natural Sciences and earned a PhD at Trinity College, Cambridge in 1985, where he studied ... Retrieved 5 May 2014. "Bingham Medalists". "Weissenberg Award to Michael Cates , The European Society of Rheology". Rheology- ...

https://en.wikipedia.org/wiki/Michael_Cates

Xu H, Liu Y, He G, Rossiter SJ, Zhang S (November 2013). "Adaptive evolution of tight junction protein claudin-14 in ... 5 (2): 90-92. doi:10.1007/bf02153744. S2CID 500691. Hahn WL (1908). "Some habits and sensory adaptations of cave-inhabiting ... 5 (5): 593-6. doi:10.1098/rsbl.2009.0378. PMC 2781971. PMID 19535367. Riley DA, Rosenzweig MR (August 1957). "Echolocation in ... 15 (5): 20190083. doi:10.1098/rsbl.2019.0083. PMC 6548736. PMID 31088283. S2CID 155091623. Slater GJ, Price SA, Santini F, ...

https://en.wikipedia.org/wiki/Animal_echolocation

Claudin-8 is a protein that in humans is encoded by the CLDN8 gene. It belongs to the group of claudins. GRCh38: Ensembl ... "Entrez Gene: CLDN8 claudin 8". Human CLDN8 genome location and CLDN8 gene details page in the UCSC Genome Browser. Kniesel U, ... Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): ... Morita K, Furuse M, Fujimoto K, Tsukita S (Mar 1999). "Claudin multigene family encoding four-transmembrane domain protein ...

https://en.wikipedia.org/wiki/CLDN8

ISBN 978-0-393-09750-4. Rice, Eric (1999). "Tradition and Imitation in Pierre Certon's Déploration for Claudin de Sermisy". ... T. 5 (12): 149-151. doi:10.2307/926163. JSTOR 926163. Dewitte, A. (1970). "De geestelijkheid van de Brugse Lieve-Vrouwkerk in ... 5. Strohm 1985, p. 153. Fallows 2001, §1 "Life", para. 7. Planchart 2004, §1 "Life". Reese 1940, p. 358. Leach 2014, p. 304. ... 5. Fallows 2001, §4 "Binchois and England". Strohm 2005, p. 243. Fallows 2001, § "Works". Bent 1981, p. 9. Bent, Margaret (1981 ...

https://en.wikipedia.org/wiki/Gilles_Binchois

Beeman N, Webb PG, Baumgartner HK (February 2012). "Occludin is required for apoptosis when claudin-claudin interactions are ... These 5 domains are separated by the 4 transmembrane domains of the protein. The nine domains are as follows: N-terminus domain ... 15 (5): 1195-219. doi:10.1089/ars.2010.3542. PMID 21235353. Walter JK, Castro V, Voss M, Gast K, Rueckert C, Piontek J, Blasig ... 117 (5): 1050-8. doi:10.1046/j.0022-202x.2001.01493.x. PMID 11710912. Traweger A, Fang D, Liu YC, Stelzhammer W, Krizbai IA, ...

https://en.wikipedia.org/wiki/Occludin

Claudin, F., Ernstson, K., Rampino, M.R., and Anguita, F. 2001. Striae, polish, imprints, rotated fractures, and related ... Ernstson, K., Claudin, F., Schüssler, U., Anguita, F. and Ernstson, T. 2001. Impact melt rocks, shock metamorphism, and ... cite web}}: Missing or empty ,title= (help) Ernstson, K., Claudin, F., Schüssler, U. & Hradil, K. (2002): The mid-Tertiary ... 1], Ernstson, K., Schüssler, U., Claudin, F., and Ernstson, T. (2003). An impact crater chain in northern Spain. Meteorite, 9, ...

https://en.wikipedia.org/wiki/Rubielos_de_la_Cérida_impact_structure

Morita K, Sasaki H, Furuse M, Tsukita S (1999). "Endothelial Claudin: Claudin-5/Tmvcf Constitutes Tight Junction Strands in ... Claudin-6 is a protein that in humans is encoded by the CLDN6 gene. It belongs to the group of claudins. The knockout mice of ... "Entrez Gene: CLDN6 claudin 6". Human CLDN6 genome location and CLDN6 gene details page in the UCSC Genome Browser. Kniesel U, ... Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): ...

https://en.wikipedia.org/wiki/CLDN6

Claudin and occludin are proteins that are essential for the formation of the tight junctions between the cells of the blood- ... The study showed that MMP-3 accomplishes this damage by degrading claudin-5, occludin, and ZO-1 (another tight junction protein ... Furuse M, Fujita K, Hiiragi T, Fujimoto K, Tsukita S (Jun 1998). "Claudin-1 and -2: novel integral membrane proteins localizing ... The WT mice were shown to have lower claudin-5 and occludin levels than the KO mice after TBI. ...

https://en.wikipedia.org/wiki/MMP3

2012 - In silico directed mutagenesis identifies the CD81/claudin-1 hepatitis C virus receptor interface. Davis C, Harris HJ, ... Cellular microbiology 15: 430-45 Link 2013 - Heterogeneous claudin-1 expression in human liver. Harris HJ, Wilson GK, Hübscher ... Hepatology 57: 854-5 Link 2014 - Hypoxia inducible factors in liver disease and hepatocellular carcinoma: current understanding ...

https://en.wikipedia.org/wiki/Jane_A._McKeating

ISBN 2710330733 Eugène de Mirecourt, Méry (1858) Text online Gustave Claudin, Méry : sa vie intime, anecdotique et littéraire ( ... in 5 acts and 10 tableaux, in prose and in verse, with Gérard de Nerval and Bernard Lopez, ballets by Adrien Text online Kilien ... 5 April 1851: Raphaël, historical comedy in 3 acts, in verse 1852: Le Sage et le Fou, three-act comedy, in verse, with Bernard ... in 5 acts and 7 tableaux, traduction du drame indien du Roi Soudraka Text online 1852: L'Imagier de Harlem, ou la Découverte de ...

https://en.wikipedia.org/wiki/Joseph_Méry

These complexes, formed primarily of members of the claudin and the occludin families, consist of about 35 different proteins, ... Epithelial cells are continuously renewed every 4-5 days through a process of cell division, maturation, and migration. Renewal ...

https://en.wikipedia.org/wiki/Intestinal_epithelium

Claudin-12 is a protein that in humans is encoded by the CLDN12 gene. It belongs to the group of claudins. GRCh38: Ensembl ... "Entrez Gene: CLDN12 claudin 12". Human CLDN12 genome location and CLDN12 gene details page in the UCSC Genome Browser. Kniesel ... 2001). "claudin-18, a novel downstream target gene for the T/EBP/NKX2.1 homeodomain transcription factor, encodes lung- and ... Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): ...

https://en.wikipedia.org/wiki/CLDN12

Famous composers of these "Parisian" chansons included Claudin de Sermisy and Clément Janequin. Janequin's La guerre, written ... Brotton, J., The Renaissance: A Very Short Introduction, OUP, 2006 ISBN 0-19-280163-5. Tanaka 1992, p. 90 Tanaka, Hidemichi ( ...

https://en.wikipedia.org/wiki/French_Renaissance

Claudin-20 is a protein that in humans is encoded by the CLDN20 gene. It belongs to the group of claudins. GRCh38: Ensembl ... "Entrez Gene: CLDN20 claudin 20". Human CLDN20 genome location and CLDN20 gene details page in the UCSC Genome Browser. Kniesel ... Hewitt KJ, Agarwal R, Morin PJ (Aug 2006). "The claudin gene family: expression in normal and neoplastic tissues". BMC Cancer. ... Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): ...

https://en.wikipedia.org/wiki/CLDN20

... is concentrated at tight junctions through its possible interaction with claudin-1 and junctional adhesion molecule". The ... 15 (5): 525-30. doi:10.1016/S0955-0674(03)00104-2. PMID 14519386. Naik UP, Eckfeld K (2004). "Junctional adhesion molecule 1 ( ...

https://en.wikipedia.org/wiki/F11_receptor

... has overexpressed HER2/neu Normal breast-like Claudin-low: a more recently described class; often triple-negative, but distinct ... MammaPrint has 5 FDA clearances and is the only FDA cleared microarray assay available. To be eligible for the MammaPrint gene ... 5 (1): 5-23. doi:10.1016/j.molonc.2010.11.003. PMC 5528267. PMID 21147047. Geyer, F. C.; Marchiò, C.; Reis-Filho, J. S. (2009 ... Retrieved 5 August 2022. This article incorporates text from this source, which is in the public domain. References for pie ...

https://en.wikipedia.org/wiki/Breast_cancer_classification

Claudin E is a molecule found in tight junctions that appears to be expressed in the EVL and required for normal zebrafish ... "The tight junction component claudin E is required for zebra fish epiboly". Developmental Dynamics. 239 (2): 715-722. doi: ... 132 (5): 1105-16. doi:10.1242/dev.01668. PMID 15689372. Kimmel CB, Warga RM (November 1987). "Indeterminate cell lineage of the ... 5 (7): e1000563. doi:10.1371/journal.pgen.1000563. PMC 2700972. PMID 19609345. Mungo Marsden; Douglas W. DeSimone (2001-09-15 ...

https://en.wikipedia.org/wiki/Epiboly

Markov AG, Falchuk EL, Kruglova NM, Radloff J, Amasheh S (January 2016). "Claudin expression in follicle-associated epithelium ... 11 (5): 770-84. doi:10.1016/j.celrep.2015.03.067. PMID 25921539. Diener M (January 2016). "Roadblock for antigens--take a ... 46 (5): 1095-104. doi:10.1023/a:1010778532240. PMID 11341655. S2CID 34204173. Ermund A, Gustafsson JK, Hansson GC, Keita AV ( ... Among the mononuclear cells, CD4+/CD25+ (10%) cells and CD8+/CD25+ (5%) cells are more abundant in Peyer's patches than in the ...

https://en.wikipedia.org/wiki/Peyer's_patch

Claudin de Sermisy, Thomas Crecquillon, Domenico Ferrabosco, Jean de Latre, Jacquet de Berchem, Jakob Meiland, Alexander ... 300 R/Vv, 123". The codex, consisting of 183 folia, is bound in parchment with the initials "P W S P" and the number "1 5 9 1" ... Contains 5 pieces Martin Rost, Die Norddeutsche Orgelkunst Vol.2 - Danzig, published by MDG, MDG MDG 319 0178-2, 2003; Contains ... 5 pieces Wolfgang Baumgratz, Orgels in Hanzesteden, published by NCRV, NCRV 9088, 1992; Contains 4 pieces Bogusław Grabowski, ...

https://en.wikipedia.org/wiki/Gdańsk_Tablature

Claudin, P; Andreotti, B (2006). "A scaling law for aeolian dunes on Mars, Venus, Earth, and for subaqueous ripples". Earth and ... Chang, Alicia (August 5, 2008). "Scientists: Salt in Mars soil not bad for life". USA Today. Associated Press. Retrieved August ... "MEPAG Goal 5: Toxic Effects of Martian Dust on Humans". Mars Exploration Program Analysis Group. NASA Jet Propulsion Laboratory ... Retrieved August 5, 2008. "Measuring Electrostatic Phenomena on Mars and the Moon" (PDF). Proceedings of The Institute of ...

https://en.wikipedia.org/wiki/Martian_soil

Claudin grabs a sword to fight them with. Raoul fires his gun at Claudin, but Anatole knocks Raoul's arm, and the shot hits the ... She is unaware that Erique Claudin loves her and was the one who funded all her singing lessons. Claude Rains as Erique Claudin ... Enraged, Claudin strangles Pleyel. Georgette, the publisher's assistant, throws etching acid in Claudin's face, horribly ... Claudin hears his concerto being played in the office and is convinced that Pleyel is trying to steal it; unbeknownst to him, a ...

https://en.wikipedia.org/wiki/Phantom_of_the_Opera_(1943_film)

"Systems Proteomics View of the Endogenous Human Claudin Protein Family". Journal of Proteome Research. 15 (2): 339-359. doi: ... 6 (5): 1997-2004. doi:10.1021/pr070025y. PMID 17397212. Binz, P. A.; Barkovich, R; Beavis, R. C.; Creasy, D; Horn, D. M.; ... 35 (5): 406-409. doi:10.1038/nbt.3790. ISSN 1087-0156. PMC 5831141. PMID 28486464. Omenn, Gilbert S.; Lane, Lydie; Lundberg, ... 88 (5): 2847-2855. doi:10.1021/acs.analchem.5b04567. ISSN 0003-2700. PMID 26849966. Keegan, Sarah; Cortens, John P; Beavis, ...

https://en.wikipedia.org/wiki/Ronald_Beavis

"Decreased lactate dehydrogenase B expression enhances claudin 1-mediated hepatoma cell invasiveness via mitochondrial defects ... 30 (5): 1799-805. PMID 20592382. Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk ... 5 (9): e12862. Bibcode:2010PLoSO...512862H. doi:10.1371/journal.pone.0012862. PMC 2943476. PMID 20877624. Swiderek K, Paneth P ... Pseudogenes have been identified on chromosomes X, 5 and 13. GRCh38: Ensembl release 89: ENSG00000111716 - Ensembl, May 2017 ...

https://en.wikipedia.org/wiki/Lactate_dehydrogenase_b

MicroRNA Gong Y, Renigunta V, Himmerkus N, Zhang J, Renigunta A, Bleich M, Hou J (April 2012). "Claudin-14 regulates renal Ca ... 108 (5): 1111-21. doi:10.1007/s00436-010-2152-z. PMID 21085987. S2CID 37782043. Miko E, Czimmerer Z, Csánky E, Boros G, Buslig ...

https://en.wikipedia.org/wiki/Mir-374_microRNA_precursor_family

Claudin de Sermisy, French composer (b. 1495) October 18 - Anne d'Alençon, French noblewoman (b. 1492) November 7 - Maldeo ... November 5 - Battle of Corrichie in Scotland: The rebellion of George Gordon, Earl of Huntly is crushed by James Stewart, Earl ... ISBN 978-0-89009-366-5. Williams, Hywel (2005). Cassell's Chronology of World History. London: Weidenfeld & Nicolson. pp. 223- ... September 5 - Katharina Zell, German Protestant reformer (b. 1497) October - George Gordon, 4th Earl of Huntly (b. 1514) ...

https://en.wikipedia.org/wiki/1562

Nevertheless, another sources document existence of mTEC unipotent progenitors that express claudin 3 and 4 (Cld3/4). These two ... "Medullary thymic epithelial cells expressing Aire represent a unique lineage derived from cells expressing claudin". Nature ... 41 (5): 753-61. doi:10.1016/j.immuni.2014.10.011. PMID 25464854. Ohigashi I, Zuklys S, Sakata M, Mayer CE, Hamazaki Y, Minato N ... 3 (5): 383-91. doi:10.1038/nri1085. PMID 12766760. S2CID 28321309. Kurobe H, Liu C, Ueno T, Saito F, Ohigashi I, Seach N, ...

https://en.wikipedia.org/wiki/Medullary_thymic_epithelial_cells

"Claudin-1 overexpression effect on lung adenocarcinoma cell line". NCBI GEO Profiles. Retrieved 4 May 2015. Vandepoele K, Van ... NBPF1 is a 1214 amino acid long protein in humans that weighs 139 kD and has an isoelectric point of around 5. A feature about ... 220 (5): 3053-60. doi:10.1007/s00429-014-0814-9. PMC 4722867. PMID 24957859. Davis JM, Searles VB, Anderson N, Keeney J, Dumas ... 5 (8): e12089. Bibcode:2010PLoSO...512089D. doi:10.1371/journal.pone.0012089. PMC 2918508. PMID 20711500. Dumas L, Sikela JM ( ...

https://en.wikipedia.org/wiki/NBPF1

Following the 20th Congress of the Communist Party of the Soviet Union in 1956 Claudin found himself increasingly at odds with ... ISBN 978-0-19-965658-5. Retrieved 2015-07-18. v t e (Articles with hCards, Articles with ISNI identifiers, Articles with VIAF ...

https://en.wikipedia.org/wiki/Fernando_Claudín

In the 16th century, Claudin de Sermisy set the psalm. In the 17th century, Henry Dumont set this psalm for La Chapelle Royale ... Verses 1-5: The Psalmist's personal experience of God's compassion; Verses 6-19: The attributes of God as seen in his ...

https://en.wikipedia.org/wiki/Psalm_103

... is concentrated at tight junctions through its possible interaction with claudin-1 and junctional adhesion molecule". J. Biol. ... Becamel C, Figge A, Poliak S, Dumuis A, Peles E, Bockaert J, Lubbert H, Ullmer C (2001). "Interaction of serotonin 5- ... MPDZ has been shown to interact with: 5-HT2C receptor, CD117, and PLEKHA1. GRCh38: Ensembl release 89: ENSG00000107186 - ... "Interaction of serotonin 5-hydroxytryptamine type 2C receptors with PDZ10 of the multi-PDZ domain protein MUPP1". J. Biol. Chem ...

https://en.wikipedia.org/wiki/MPDZ

2 January 2020). "An RNA vaccine drives expansion and efficacy of claudin-CAR-T cells against solid tumors". Science. 367 (6476 ... "Claudin-18 splice variant 2 is a pan-cancer target suitable for therapeutic antibody development". Clinical Cancer Research. 14 ... Plus CAPOX Compared With Placebo Plus CAPOX as First-line Treatment of Subjects With Claudin (CLDN) 18.2-Positive, HER2- ... 72 (5): 1081-1091. doi:10.1158/0008-5472.CAN-11-3722. ISSN 0008-5472. PMID 22237626. Wikidata Q39413641. Cedrik M Britten; ...

https://en.wikipedia.org/wiki/Uğur_Şahin

Van Itallie CM, Mitic LL, Anderson JM (July 2012). "SUMOylation of claudin-2". Annals of the New York Academy of Sciences. 1258 ... 278 (5344): 1803-5. Bibcode:1997Sci...278.1803C. doi:10.1126/science.278.5344.1803. PMID 9388184. Liu B, Liao J, Rao X, Kushner ... 35 (5): 669-82. doi:10.1016/j.molcel.2009.07.013. PMC 2771690. PMID 19748360. Palvimo JJ (December 2007). "PIAS proteins as ... 5 (8): 593-605. doi:10.1038/nri1667. PMID 16056253. S2CID 7466028. University, James D. Watson, Cold Spring Harbor Laboratory, ...

https://en.wikipedia.org/wiki/Protein_inhibitor_of_activated_STAT

... expression is significantly increased after the overexpression of claudin-1 in lung adenocarcinoma cell lines. Claudin ... C11orf49 expression is significantly increased after the overexpression of Claudin-1 in lung adenocarcinoma cells. C11orf49 ... There are 5 known isoforms for the C11orf49 protein with isoform 2 being the most complete protein, encoded by transcript ... Table 5. List of binding transcription factors to the GXP_204543 promoter. Both microarray expression patterns and RNA-Seq data ...

https://en.wikipedia.org/wiki/C11orf49

"Medullary thymic epithelial cells expressing Aire represent a unique lineage derived from cells expressing claudin". Nature ... 3 (5): 383-391. doi:10.1038/nri1085. ISSN 1474-1733. PMID 12766760. S2CID 28321309. Ueno, Tomoo; Saito, Fumi; Gray, Daniel H. D ... 5 (5): 546-553. doi:10.1038/ni1064. ISSN 1529-2908. PMID 15098031. S2CID 10282524. Rossi, Simona W.; Jenkinson, William E.; ... 41 (5): 753-761. doi:10.1016/j.immuni.2014.10.011. ISSN 1074-7613. PMID 25464854. (Immunology, Thymus, Epithelial cells). ...

https://en.wikipedia.org/wiki/Cortical_thymic_epithelial_cells

... as well as production of epithelial proteins such as desmoplakin and claudin, and activate the expression of vimentin and ... and 5) "pulling" the trailing edge toward movement through the newly formed defects in the matrix structure. Since the cells ...

https://en.wikipedia.org/wiki/Invasion_(cancer)

... have increased blood-brain barrier permeability due to decreased expression of tight junction proteins occludin and claudin-5 ... 25 (5): 378-387. doi:10.1016/j.smim.2013.09.003. PMID 24209708. Palm, Noah W.; de Zoete, Marcel R.; Flavell, Richard A. (August ... 13 (5): 321-335. doi:10.1038/nri3430. PMID 23618829. S2CID 205491968. Hooper Lora V., Bry Lynn, Falk Per G., Gordon Jeffrey I ... 9 (5): 313-323. doi:10.1038/nri2515. PMC 4095778. PMID 19343057. Mazmanian, Sarkis K.; Round, June L.; Kasper, Dennis L. (2008 ...

https://en.wikipedia.org/wiki/Microbial_symbiosis_and_immunity

... claudin-7 and low expression of occludin in OSCC. Only claudin-7 expression showed impact on clinic-pathological parameter of ... Expression of claudin-5, claudin-7 and occludin in oral squamous cell carcinoma and their clinico-pathological significance. ... Only loss of claudin-7 expression was associated with the high pathologic grade, advanced TNM staging, large tumor size, the ... The claudin-5 immunoreactivity was observed in 26.6% of cases. The positive immunoreactivity of claudin-7 is more noted (93.3 ...

https://roderic.uv.es/handle/10550/54684

Rabbit Polyclonal Claudin 1 antibody C-Term for IHC, WB. Order anti-Claudin 1 antibody ABIN2704650. ... Target Details for Claudin 1 (hide) Target Claudin 1 (CLDN1) Alternative Name Claudin 1 (CLDN1 Products) Synonyms CLD1, ILVASC ... Target See all Claudin 1 (CLDN1) Antibodies Claudin 1 (CLDN1) Binding Specificity All epitopes for Claudin 1 antibodies * AA ... SEMP1, AI596271, cldn19, claudin-1, cld1, ilvasc, semp1, CLDN1, claudin 1, claudin 1 S homeolog, CLDN1, Cldn1, cldn1, cldn1.S ...

https://www.antibodies-online.com/antibody/2704650/anti-Claudin+1+CLDN1+C-Term+antibody/

Claudin low is often triple-negative, but distinct in that there is low expression of cell-cell junction proteins including E- ... Phenotypic and molecular characterization of the claudin-low intrinsic subtype of breast cancer. Breast Cancer Research. 2010; ... 1995;81(5):727-36.. *21. Malkin D, Li FP, Strong LC, Fraumeni J, Nelson CE, Kim DH, et al. Germ line p53 mutations in a ... 2010;11(5):326.. *18. Slamon DJ, Godolphin W, Jones LA, Holt JA, Wong SG, Keith DE, et al. Studies of the HER2/neu proto- ...

https://www.intechopen.com/chapters/48189

Claudin, 1881).. John Ferguson (1837-1916), Professor of Chemistry, University of Glasgow: purchased at the Chasles sale 1 Aug ... 18th century): on 5/7v (f. 39v) annotation (slightly cropped) in capitals "Este libro es de Micer Royo".. Michel Chasles (1793- ...

https://www.gla.ac.uk/myglasgow/incunabula/a-zofauthorsa-j/m34/

Claudin‑9 is a novel prognostic biomarker for endometrial cancer. Endo Y, Sugimoto K, Kobayashi M, Kobayashi Y, Kojima M, ... EpCAM proteolysis and release of complexed claudin-7 repair and maintain the tight junction barrier. Higashi T, Saito AC, ... 2022 Nov;61(5):135. doi: 10.3892/ijo.2022.5425. Epub 2022 Sep 21. Int J Oncol. 2022. PMID: 36129146 Free PMC article. ... 2022 Nov 5;12(1):18745. doi: 10.1038/s41598-022-23524-y. Sci Rep. 2022. PMID: 36335161 Free PMC article. ...

https://pubmed.ncbi.nlm.nih.gov/?term=Higashi+A&cauthor_id=6549543

Claudin-5 and VE-Cadherin expression was not significantly higher under hypoxic condition (C). Expression of other tight ... Results show improved organization of claudin-5 in organoids that were treated with SDG or 2-AG for 48 hours before culturing ... These studies showed significant increase in blood occludin levels and non-significant levels in blood claudin-5 levels63. ... Results also showed maintenance of claudin-5 and beta catenin under hypoxic condition when organoids were treated with SDG and ...

https://www.nature.com/articles/s41598-020-66487-8?elqTrackId=c6110966b7b541e69110345561e951e8&error=cookies_not_supported&code=612964a8-97bb-4896-90e4-e601ee53fd10

FHHNC is caused by mutations in the gene CLDN16, which encodes for paracellin-1 (claudin-16), [18] a member of the claudin ... 16] In humans, mutations in the claudin-16 (previously known as paracellin-1) and claudin-19 genes cause a hereditary disease, ... 17, 18, 19] Mutations in claudin-19 are also associated with severe ocular involvement. [16] ... Unusual clinical presentation and possible rescue of a novel claudin-16 mutation. J Clin Endocrinol Metab. 2006 Aug. 91(8):3076 ...

https://www.medscape.com/answers/2038394-35951/what-is-the-incidence-of-hypomagnesemia-among-patients-treated-with-cetuximab

Claudin III 119. Bechtel E-170. Pell 220. CRF X 4. ISTC ia00118200. ... 34a Z. 5 Cy commance la preface du premier liure de eſope.  … Endet Bl. 146b Cy finiſſent les ſubtilles fables de eſope ...

https://www.gesamtkatalogderwiegendrucke.de/docs/GW00368.htm

So, we have shown in these animals that we control claudin-5 and occludin levels. Over time, we can decrease the levels of ... One of them is called claudin-5, the other one is called occludin. These components hold endothelial cells together very, very ... Researcher Matthew Campbell has found a way to do this by deactivating two molecules - called claudin-5 and occludin - which ... claudin-5 and occludin, is very, very safe when its administered into a vein of a larger animal such as a non-human primate. ...

https://www.thenakedscientists.com/articles/interviews/stopping-alzheimers-occurring

Claudin II 322. Ce³ B-1198. IGICorr 2155A. Pell 2991. CRF I 369. CRF XII 158. BSB-Ink B-915. Pr 8313. BMC VIII 188.IA 40713. ... Claudin IV 400-402. CBB 901. Ce³ B-1202. IBE 1215. IDL 1051. IGI 2161. Pell 2996. CRF III 229. CRF XVII 259. Schlechter-Ries ... Claudin III 463. Pell 2997. CRF VI 502. Oates 3208. ISTC ib01197400. ... 2:65G, 3:84G, 5:96G, 6:ca.80G. Init. a, b. Rubr. β, γ. 10 Hlzs., darunter 5 schematische. DrM I des Etienne Jehannot KolTit. ...

https://gesamtkatalogderwiegendrucke.de/docs/BRICTHO.htm

Claudin-5: gatekeeper of neurological function. Fluids Barriers CNS 2019;16:3. [PMID: 30691500 DOI: 10.1186/s12987-019-0123-z] ... 5. M Tóth O, Menyhárt Á, Frank R, Hantosi D, Farkas E, Bari F. Tissue Acidosis Associated with Ischemic Stroke to Guide ... eNeuro 2018;5:ENEURO. [PMID: 30073201 DOI: 10.1523/ENEURO.0116-18.2018] [Cited by in Crossref: 18] [Cited by in F6Publishing: ... PMID: 31815209 DOI: 10.1016/j.cophys.2019.10.013] [Cited by in Crossref: 3] [Cited by in F6Publishing: 5] [Article Influence: ...

https://wjgnet.com/2307-8960/CitedArticlesInF6?id=10.1523%2Feneuro.0116-18.2018

The expression of claudin-5, occludin, ZO-1, and connexin-43 was significantly decreased. The damage caused by ZnO NPs could be ... 5.. Lee JH, Huh YM, Jun YW, et al. Artificially engineered magnetic nanoparticles for ultra-sensitive molecular imaging. Nat ... In exposed carbon nanotubes to female mice, delivery of the first litter was delayed by an average of 5 days.67 ... Ultrasensitive molecular imaging nanoprobes can be used to detect targeted biological structures.5 AuNPs are a reliable label- ...

https://www.dovepress.com/potential-adverse-effects-of-nanoparticles-on-the-reproductive-system-peer-reviewed-fulltext-article-IJN

... occludin and claudin-5) and influx and efflux transporters (Glut-1 and P-glycoprotein), the latter supporting evidence for ... occludin and claudin-5) and influx and efflux transporters (Glut-1 and P-glycoprotein), the latter supporting evidence for ... Human adult brain sections were used to test the BBB-specific markers (Glut 1, P-gp, Claudin-5, Occludin), Cx43 antibody was ... and occludin/claudin-5. (A-C) A radial microvessel surrounded by GFAP-reactive RG fibers is revealed by the Glut-1 reactive ...

https://www.frontiersin.org/articles/10.3389/fnins.2014.00324/full

ZONAB also regulates the expression and localisation of tight junction proteins JACOP and claudin-5. Also, endothelial ZONAB ...

https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.798756

Claudin and occludin expression and function in the seminiferous epithelium. Carla M.K. Morrow, Dolores Mruk, C. Yan Cheng, Rex ... Dive into the research topics of Claudin and occludin expression and function in the seminiferous epithelium. Together they ...

https://experts.illinois.edu/en/publications/claudin-and-occludin-expression-and-function-in-the-seminiferous-/fingerprints/

2. Hudson N, Celkova L, Doyle S, Campbell M, Aberrant BMAL1 dependent claudin-5 cycling induces geographic atrophy, ... Dysregulated claudin-5 cycling in the inner retina causes retinal pigment epithelial cell atrophy, JCI Insight, 4, (15), 2019, ... 5), 2013, p920-928 Journal Article, 2013 TARA - Full Text DOI ...

https://www.tcd.ie/medicine/clinical-medicine/research/researchers/DOYLES8

Microbial-derived butyrate promotes epithelial barrier function through IL-10 receptor-dependent repression of claudin-2. J. ... Figure 5. IgA values (described as ng/g feces) from fecal samples of the probiotic group (gray bar), and the control group ( ... Figure 5. IgA values (described as ng/g feces) from fecal samples of the probiotic group (gray bar), and the control group ( ... Figure 5 shows that the total IgA levels in the fecal extracts of the probiotic group were higher than those in the control, ...

https://www.mdpi.com/2072-6643/11/5/1150/htm

Claudin Cherelus led Alcorns defense with 14 total tackles and one sack. McCullum had seven tackles to go with his game-ending ... Javonta Leatherwoods 5-yard touchdown run for Alcorn State tied the game 16-16 with 6:48 remaining. Howard scored on a 2-yard ... Alcorn State (4-5, 3-3 Southwestern Athletic Conference) ended a three-game losing streak and has won the last five meetings ... against Prairie View A&M (5-4, 4-2).. Alcorn will return home to face Bethune-Cookman next Saturday, Nov. 12, at 2 p.m. at Jack ...

https://www.vicksburgpost.com/2022/11/04/alcorn-state-beats-prairie-view-in-overtime-to-stop-losing-streak/

Roundabout 4 regulates blood-tumor barrier permeability through the modulation of ZO-1, Occludin, and Claudin-5 expression. J ... 5. Pircher A, Hilbe W, Heidegger I, Drevs J, Tichelli A, Medinger M. Biomarkers in tumor angiogenesis and anti-angiogenic ... Figure 5 Kaplan Meier curves analyzing overall survival of patients with high (green) versus low (blue) A) Robo 4 and B) Slit 2 ... In general, PCa has a favorable disease course and up to 84% and 74% of patients have a 5- year and 10-year disease free ...

https://medsci.org/v16p0115.htm

f Quantification of claudin-5 and ZO-1 in the serum. Scar bars = 100 μm in (a-c), Scar bars = 2 μm on the lower power lens maps ... Serum was separated by centrifugation and stored at − 80 °C until quantitative analysis of claudin-5 and ZO-1 using ELISA kits ... c Immunohistochemical sections showing increased expression of EPO and VEGF-A and decreased expression of claudin-5 and ZO-1 ... 6c, e), while serology revealed significantly increased serum concentrations of claudin-5 and ZO-1 in the model group (P , 0.05 ...

https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-022-03374-y

Category: claudin 6 antibody. Bacterial triacylglycerol lipase is a potential cholesterol esterase: Identification of a key ... Antibodies, Assay Kits, Biology Cells, cDNA, claudin 6 antibody, Clia Kits, Culture Cells, cyp27b1 antibody, Devices, DNA, DNA ... Antibodies, Assay Kits, Biology Cells, cDNA, claudin 6 antibody, Clia Kits, Culture Cells, Devices, DNA, DNA Templates, DNA ... Antibodies, Assay Kits, Biology Cells, cDNA, claudin 6 antibody, Clia Kits, Culture Cells, cyp27b1 antibody, Devices, DNA, DNA ...

https://allelebio.com/category/claudin-6-antibody/

Claudin-18 splice variant 2 is a pan-cancer target suitable for therapeutic antibody development.. Clin Cancer Res. . 2008;14( ... Claudin-18, a novel downstream target gene for the T/EBP/NKX2.1 homeodomain transcription factor, encodes lung- and stomach- ... Comparison of Claudin 18.2 expression in primary tumors and lymph nodes metastases in Japanese patients with gastric ... Astellas Announces Zolbetuximab Meets Primary Endpoint in Phase 3 SPOTLIGHT Trial as First-Line Treatment in Claudin 18.2 ...

https://pressreach.com/health/astellas-announces-zolbetuximab-meets-primary-endpoint-in-phase-3-spotlight-trial-as-first-line-treatment-in-claudin-18-2-positive-her2-negative-locally-advanced-or-metastatic-gastric-and-gastroesoph/

Claudin De Sermisy (1) * Dominique Phinot (1) * Jean Mouton (1) * Johannes Lupi (1) ...

https://www.platekompaniet.no/medvirkende/brabant-ensemble/

... occludin and claudin-5. In mice just two months old, the numbers of those important tight junction proteins in the linings of ...

https://www.news-medical.net/news/2008/04/07/37063.aspx

ERNSTSON CLAUDIN IMPACT STRUCTURES - METEORITE CRATERS. Research on impact geology, geophysics, petrology, and impact cratering ... 5. Breccia generations in the basal breccia; see below hammer. Central-uplift chain, northeast of Caudé. ...

http://www.impact-structures.com/impact-spain/the-rubielos-de-la-cerida-impact-basin/basal-suevite-breccia-in-the-rubielos-de-la-cerida-impact-basin/

Influenza Infects Lung Microvascular Endothelium Leading to Microvascular Leak: Role of Apoptosis and Claudin-5. ...

https://criticalcarecanada.com/archives/presentations-2012-monday/

PAX8, SF1, and GATA-3 were rarely positive, while claudin-4, FOXL2, and TTF-1 were consistently negative. All sequenced tumors ... and claudin-4. One of three cases was positive for WT-1. Targeted MPS was successfully performed on 4 of 5 tumors, and showed ... claudin-4, SMARCA4, and SMARCB1. Targeted molecular profiling was performed on 15 cases. Patients with SDUS were significantly ... Conversely, 5/14 benign cervices (36%) were misinterpreted as pattern-A by ≥2 reviewers. The number of glands per 20× field was ...

https://profiles.stanford.edu/187369

... ... levels of the claudin 1 protein. We propose that claudin 1 functions both as a tumor suppressor as well as a tumor enhancer/ ... In this paper, we discuss recent advances in our understanding of the potential role of claudin 1 in breast cancer. We also ...

https://mspace.lib.umanitoba.ca/xmlui/handle/1993/30318

Claudin-10 is required for relay of left-right patterning cues from Hensens node to the lateral plate mesoderm,. Developmental ... Claudin-1 is a p63 target gene with a crucial role in epithelial development PLoS ONE , 3, 7. ... Activation of an SP binding site is crucial for the expression of Claudin 1 in rat epididymal principal cells Biology of ... In utero exposure to tributyltin alters the expression of E-cadherin and localization of claudin-1 in intercellular junctions ...

https://inrs.ca/la-recherche/professeurs/daniel-g-cyr/

Occludin Proteins Protein 18.2 Endothelial Genes 2019 2022 Cadherin 2020 Exon Colony Vascular Tight Expression Sequence Mice Tumor Cell Levels Person-to-person cont Breast cancer Studies Model Develop Time Found

Background: Claudin and occludin are the important tight junctions protein in human. (uv.es)
The objective of this study was to investigate the expression of claudin-5, claudin-7 and occludin in oral squamous cell carcinoma (OSCC) and their relationships with the prognostically-related clinico-pathologic features. (uv.es)
Material and Methods: Standard indirect immunohistochemical technique using anti-claudin-5, anti-claudin-7 and anti-occludin was performed in formalin-fixed paraffin-embedded tissue sections of 66 OSCC samples from Faculty of Dentistry, Chulalongkorn University. (uv.es)
Conclusions: The results showed expression of claudin-5, claudin-7 and low expression of occludin in OSCC. (uv.es)
One of them is called claudin-5, the other one is called occludin. (thenakedscientists.com)
So, we have shown in these animals that we control claudin-5 and occludin levels. (thenakedscientists.com)
We also recently have data from a non-human primate study whereby we've shown that the molecule that we use that targets these molecules, claudin-5 and occludin, is very, very safe when it's administered into a vein of a larger animal such as a non-human primate. (thenakedscientists.com)
The BBB status of cortex microvessels was examined at a defined stage of cortex development, at the end of neuroblast waves of migration, and before cortex lamination, with BBB-endothelial cell markers, namely tight junction (TJ) proteins (occludin and claudin-5) and influx and efflux transporters (Glut-1 and P-glycoprotein), the latter supporting evidence for functional effectiveness of the fetal BBB. (frontiersin.org)
As the dose of ES increased, the relative expressions of claudin-5 and occludin protein tended to increase, while the relative expressions of VCAM-1, ICAM-1 and VEGF tended to decrease. (cjeo-journal.org)

ZONAB also regulates the expression and localisation of tight junction proteins JACOP and claudin-5. (bl.uk)
The tetraspan membrane protein is a member of the claudin family of tight junction proteins. (lamerie.com)
Many proteins in the claudin family have high sequence identity. (lamerie.com)

Recognizes endogenous levels of Claudin 1 protein. (antibodies-online.com)
We also discuss the significance of a subset of estrogen receptor negative breast cancers which express "high" levels of the claudin 1 protein. (umanitoba.ca)
Blood-Mind Barrier Protein Claudin-5 Expressed in Paired Xenopus laevis Oocytes Mediates Cell-Cell Interplay Claudin-5 determines the sealing properties of blood-brain barrier tight junctions and its operate is impaired in neurodegenerative and neuroinflammatory issues. (konka-chemical.com)
Caused by a mutation in the CLDN1 gene on chromosome 3q28 coding for the tight junction protein claudin-1. (cdc.gov)

Zolbetuximab is an investigational first-in-class monoclonal antibody targeting Claudin 18.2 (CLDN18.2), for the first-line treatment of patients with CLDN18.2-positive, HER2-negative, locally advanced unresectable or metastatic gastric or gastroesophageal junction (GEJ) adenocarcinoma. (pressreach.com)

A claudin subtype that is found localized to TIGHT JUNCTIONS in VASCULAR ENDOTHELIAL CELLS . (bvsalud.org)
Frequent expression of conventional endothelial markers in pleural mesothelioma: Usefulness of claudin-5 as well as combined traditional markers to distinguish mesothelioma from angiosarcoma. (or.jp)

By analyzing the differential H2Bub1-enriched genes in claudin-low and basal-like subtypes, we found that miR200 family is highly enriched for H2Bub1 and has higher levels of expression in basal-like cells. (tmc.edu)
Studies on liver development in model organisms have identified genes and signalling pathways vital for the formation of the hepatic lineage [ 5 , 6 ] and, in recent years, a number of laboratories have reported various protocols that can successfully differentiate both hESCs and hiPSCs into hepatocyte-like cells by recapitulating liver development. (biomedcentral.com)

Cancer Res (2019) 79 (5): 970-981. (aacrjournals.org)

Epub 2022 Nov 5. (nih.gov)
Sci Rep. 2022 Nov 5;12(1):18745. (nih.gov)
Food Sci Anim Resour 2022;42(5):903-914. (kosfaj.org)

Loss of E-Cadherin, which is a main determinant of epithelial tissue organization and cell polarity, is considered a hallmark of EMT ( 5 ). (iiarjournals.org)

21(5)2020 Feb 25. (bvsalud.org)

The exogenous promoter and human FGL1 coding sequence was inserted to replace part of murine exon 4 and all of exons 5-7. (biocytogen.com)

miR200b overexpression decreases cell proliferation and colony formation specifically in claudin-low cells. (tmc.edu)

Only loss of claudin-7 expression was associated with the high pathologic grade, advanced TNM staging, large tumor size, the presence of microscopic perineural, vascular invasions and regional lymph node involvement. (uv.es)
Dysregulation of claudin-5 in HIV-induced interstitial pneumonitis and lung vascular injury. (bvsalud.org)

EpCAM proteolysis and release of complexed claudin-7 repair and maintain the tight junction barrier. (nih.gov)

There is a tendency towards the association of the higher claudin-7 expression and a longer survival time (P=0.012). (uv.es)
Only claudin-7 expression showed impact on clinic-pathological parameter of OSCC. (uv.es)
Association of Cytokeratin 5 and Claudin 3 expression with BRCA1 and BRCA2 germline mutations in women with early breast cancer. (cdc.gov)

KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human Claudin 1. (antibodies-online.com)

B-hFGL1 MC38 cells (5×105) and wild-type MC38 cells (5×105) were subcutaneously implanted into C57BL/6N mice (female, 8-week-old, n=6). (biocytogen.com)

We propose that claudin 1 functions both as a tumor suppressor as well as a tumor enhancer/facilitator in breast cancer. (umanitoba.ca)
Claudin 6 (CLDN6) is a compelling tumor antigen. (lamerie.com)
The facts that preliminary clinical experience shows high anti-tumor activity of the first drug candidate and that the competitive field still is limited, make claudin 6 an exceptionally attractive target for drug discovery and development. (lamerie.com)

of the 5 cell passages for genogroup I and II viruses. (cdc.gov)
By examining the global levels of histone modifications in distinct subtypes, I found that H2Bub1 level is lower in claudin-low breast cancer cell lines compared with basal-like breast cancer cell lines. (tmc.edu)
Cytopathic effect and norovirus RNA were detected at each of the 5 cell passages for genogroup I and II viruses. (cdc.gov)

However, the mRNA levels of deubiquitinases and E3 ligases targeting H2Bub1 have no significant difference between basal-like and claudin-low subtypes. (tmc.edu)

Representative models of differentiated human intes- transmission are ingestion of contaminated food and water tinal epithelium can be established by growing cells in 3 and person-to-person contact ( 5 ). (cdc.gov)
The most common routes of norovirus transmission are ingestion of contaminated food and water and person-to-person contact ( 5 ). (cdc.gov)

In this paper, we discuss recent advances in our understanding of the potential role of claudin 1 in breast cancer. (umanitoba.ca)
Molecular profiling has identified 5 distinct subtypes of breast cancer, luminal A, luminal B, HER2-enriched, basal-like, and claudin-low breast cancer. (tmc.edu)

The Nonlinearity in Condensed Matter: Proceedings of the Sixth Annual Conference, Center for Nonlinear Studies, Los Alamos, New Mexico, 5-9 May, 1986 has not powered. (alba-foto.de)

In vitro differentiation of small intestinal epithelium that nausea, vomiting, and watery diarrhea within 12-24 hours approaches physiologic functionality of the in vivo host of exposure and typically remain symptomatic for 1-2 may allow for the development of a pathogenesis model days ( 5 ). (cdc.gov)

Infected persons may develop symptoms of severe nausea, vomiting, and watery diarrhea within 12-24 hours of exposure and typically remain symptomatic for 1-2 days ( 5 ). (cdc.gov)

Authenticate with the 5 digit One Time Password (OTP) sent to your registered mobile number. (srgroupchemical.com)

The fluorescent probe 4,4-difluoro-5-(4-phenyl-1, 3-butadienyl)-4-bora-3a, 4a-diaza-s-indacene-3-undecanoic acidity (C11-BODIPY), found in the PLIR technique, modifies its fluorescence from reddish colored (FL2) to green (FL1)8,10 due to oxidation. (healthweblognews.info)