Claudin 1. Medical search

A large family of transmembrane proteins found in TIGHT JUNCTIONS. They take part in the formation of paracellular barriers and pores that regulate paracellular permeability.

A ubiquitously-expressed claudin subtype that acts as a general barrier-forming protein in TIGHT JUNCTIONS. Elevated expression of claudin-3 is found in a variety of tumor cell types, suggesting its role as a therapeutic target for specific ANTINEOPLASTIC AGENTS.

An integral membrane protein that is localized to TIGHT JUNCTIONS, where it plays a role in controlling the paracellular permeability of polarized cells. Mutations in the gene for claudin-1 are associated with Neonatal Ichthyosis-Sclerosing Cholangitis (NISCH) Syndrome.

A claudin subtype that takes part in maintaining the barrier-forming property of TIGHT JUNCTIONS. Claudin-4 is found associated with CLAUDIN-8 in the KIDNEY COLLECTING DUCT where it may play a role in paracellular chloride ion reabsorption.

Cell-cell junctions that seal adjacent epithelial cells together, preventing the passage of most dissolved molecules from one side of the epithelial sheet to the other. (Alberts et al., Molecular Biology of the Cell, 2nd ed, p22)

A claudin subtype that is found localized to TIGHT JUNCTIONS in VASCULAR ENDOTHELIAL CELLS. The protein was initially identified as one of several proteins which are deleted in VELOCARDIOFACIAL SYNDROME and may play an important role in maintaining the integrity of the BLOOD-BRAIN BARRIER.

Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.

A MARVEL domain protein that plays an important role in the formation and regulation of the TIGHT JUNCTION paracellular permeability barrier.

A 195-kDa zonula occludens protein that is distinguished by the presence of a ZU5 domain at the C-terminal of the molecule.

A zonula occludens protein subtype found in epithelial cell junctions. Several isoforms of zonula occludens-2 protein exist due to use of alternative promoter regions and alternative mRNA splicings.

A claudin subtype that is associated with the formation of cation-selective channels and increased epithelial permeability. It is localized to the TIGHT JUNCTIONS of the PROXIMAL KIDNEY TUBULE and INTESTINAL EPITHELIUM.

A specialized barrier, in the TESTIS, between the interstitial BLOOD compartment and the adluminal compartment of the SEMINIFEROUS TUBULES. The barrier is formed by layers of cells from the VASCULAR ENDOTHELIUM of the capillary BLOOD VESSELS, to the SEMINIFEROUS EPITHELIUM of the seminiferous tubules. TIGHT JUNCTIONS form between adjacent SERTOLI CELLS, as well as between the ENDOTHELIAL CELLS.

Property of membranes and other structures to permit passage of light, heat, gases, liquids, metabolites, and mineral ions.

The resistance to the flow of either alternating or direct electrical current.

The technique of placing cells or tissue in a supporting medium so that thin sections can be cut using a microtome. The medium can be paraffin wax (PARAFFIN EMBEDDING) or plastics (PLASTIC EMBEDDING) such as epoxy resins.

A genus of pufferfish commonly used for research.

Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.

Excretion of abnormally high level of CALCIUM in the URINE, greater than 4 mg/kg/day.

An inherited renal disorder characterized by defective NaCl reabsorption in the convoluted DISTAL KIDNEY TUBULE leading to HYPOKALEMIA. In contrast with BARTTER SYNDROME, Gitelman syndrome includes hypomagnesemia and normocalcemic hypocalciuria, and is caused by mutations in the thiazide-sensitive SODIUM-POTASSIUM-CHLORIDE SYMPORTERS.

A condition characterized by calcification of the renal tissue itself. It is usually seen in distal RENAL TUBULAR ACIDOSIS with calcium deposition in the DISTAL KIDNEY TUBULES and the surrounding interstitium. Nephrocalcinosis causes RENAL INSUFFICIENCY.

A quality of cell membranes which permits the passage of solvents and solutes into and out of cells.

Human colonic ADENOCARCINOMA cells that are able to express differentiation features characteristic of mature intestinal cells, such as ENTEROCYTES. These cells are valuable in vitro tools for studies related to intestinal cell function and differentiation.

The U-shaped portion of the renal tubule in the KIDNEY MEDULLA, consisting of a descending limb and an ascending limb. It is situated between the PROXIMAL KIDNEY TUBULE and the DISTAL KIDNEY TUBULE.

Preparation for electron microscopy of minute replicas of exposed surfaces of the cell which have been ruptured in the frozen state. The specimen is frozen, then cleaved under high vacuum at the same temperature. The exposed surface is shadowed with carbon and platinum and coated with carbon to obtain a carbon replica.

Cells of epithelial origin possessing specialized sensory functions. They include cells that are found in the TASTE BUDS; OLFACTORY MUCOSA; COCHLEA; and NEUROEPITHELIAL BODIES.

One or more layers of EPITHELIAL CELLS, supported by the basal lamina, which covers the inner or outer surfaces of the body.

Paired respiratory organs of fishes and some amphibians that are analogous to lungs. They are richly supplied with blood vessels by which oxygen and carbon dioxide are exchanged directly with the environment.

The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)

Anchoring points where the CYTOSKELETON of neighboring cells are connected to each other. They are composed of specialized areas of the plasma membrane where bundles of the ACTIN CYTOSKELETON attach to the membrane through the transmembrane linkers, CADHERINS, which in turn attach through their extracellular domains to cadherins in the neighboring cell membranes. In sheets of cells, they form into adhesion belts (zonula adherens) that go all the way around a cell.

Supporting cells projecting inward from the basement membrane of SEMINIFEROUS TUBULES. They surround and nourish the developing male germ cells and secrete ANDROGEN-BINDING PROTEIN and hormones such as ANTI-MULLERIAN HORMONE. The tight junctions of Sertoli cells with the SPERMATOGONIA and SPERMATOCYTES provide a BLOOD-TESTIS BARRIER.

A usually benign glandular tumor composed of oxyphil cells, large cells with small irregular nuclei and dense acidophilic granules due to the presence of abundant MITOCHONDRIA. Oxyphil cells, also known as oncocytes, are found in oncocytomas of the kidney, salivary glands, and endocrine glands. In the thyroid gland, oxyphil cells are known as Hurthle cells and Askanazy cells.

Histochemical localization of immunoreactive substances using labeled antibodies as reagents.

Direct contact of a cell with a neighboring cell. Most such junctions are too small to be resolved by light microscopy, but they can be visualized by conventional or freeze-fracture electron microscopy, both of which show that the interacting CELL MEMBRANE and often the underlying CYTOPLASM and the intervening EXTRACELLULAR SPACE are highly specialized in these regions. (From Alberts et al., Molecular Biology of the Cell, 2d ed, p792)

Established cell cultures that have the potential to propagate indefinitely.

Different forms of a protein that may be produced from different GENES, or from the same gene by ALTERNATIVE SPLICING.

The artificial induction of GENE SILENCING by the use of RNA INTERFERENCE to reduce the expression of a specific gene. It includes the use of DOUBLE-STRANDED RNA, such as SMALL INTERFERING RNA and RNA containing HAIRPIN LOOP SEQUENCE, and ANTI-SENSE OLIGONUCLEOTIDES.

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism.

Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.

A form of fluorescent antibody technique commonly used to detect serum antibodies and immune complexes in tissues and microorganisms in specimens from patients with infectious diseases. The technique involves formation of an antigen-antibody complex which is labeled with fluorescein-conjugated anti-immunoglobulin antibody. (From Bennington, Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)

Degree of saltiness, which is largely the OSMOLAR CONCENTRATION of SODIUM CHLORIDE plus any other SALTS present. It is an ecological factor of considerable importance, influencing the types of organisms that live in an ENVIRONMENT.

The simultaneous analysis of multiple samples of TISSUES or CELLS from BIOPSY or in vitro culture that have been arranged in an array format on slides or microchips.

The most common etiologic agent of GAS GANGRENE. It is differentiable into several distinct types based on the distribution of twelve different toxins.

A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

A general term for the complete or partial loss of the ability to hear from one or both ears.

RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.

Lining of the INTESTINES, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. In the SMALL INTESTINE, the mucosa is characterized by a series of folds and abundance of absorptive cells (ENTEROCYTES) with MICROVILLI.

The part of the inner ear (LABYRINTH) that is concerned with hearing. It forms the anterior part of the labyrinth, as a snail-like structure that is situated almost horizontally anterior to the VESTIBULAR LABYRINTH.

Phenotypic changes of EPITHELIAL CELLS to MESENCHYME type, which increase cell mobility critical in many developmental processes such as NEURAL TUBE development. NEOPLASM METASTASIS and DISEASE PROGRESSION may also induce this transition.

The portion of renal tubule that begins from the enlarged segment of the ascending limb of the LOOP OF HENLE. It reenters the KIDNEY CORTEX and forms the convoluted segments of the distal tubule.

Substances that are toxic to the intestinal tract causing vomiting, diarrhea, etc.; most common enterotoxins are produced by bacteria.

Male germ cells derived from SPERMATOGONIA. The euploid primary spermatocytes undergo MEIOSIS and give rise to the haploid secondary spermatocytes which in turn give rise to SPERMATIDS.

Membrane-limited structures derived from the plasma membrane or various intracellular membranes which function in storage, transport or metabolism.

A malignant neoplasm arising from tenosynovial tissue of the joints and in synovial cells of tendons and bursae. The legs are the most common site, but the tumor can occur in the abdominal wall and other trunk muscles. There are two recognized types: the monophasic (characterized by sheaths of monotonous spindle cells) and the biphasic (characterized by slit-like spaces or clefts within the tumor, lined by cuboidal or tall columnar epithelial cells). These sarcomas occur most commonly in the second and fourth decades of life. (From Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1363)

A genetic rearrangement through loss of segments of DNA or RNA, bringing sequences which are normally separated into close proximity. This deletion may be detected using cytogenetic techniques and can also be inferred from the phenotype, indicating a deletion at one specific locus.

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.

Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.

The mucous membrane lining the RESPIRATORY TRACT, including the NASAL CAVITY; the LARYNX; the TRACHEA; and the BRONCHI tree. The respiratory mucosa consists of various types of epithelial cells ranging from ciliated columnar to simple squamous, mucous GOBLET CELLS, and glands containing both mucous and serous cells.

Carcinoma that arises from the PANCREATIC DUCTS. It accounts for the majority of cancers derived from the PANCREAS.

Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.

The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.

An EPITHELIUM with MUCUS-secreting cells, such as GOBLET CELLS. It forms the lining of many body cavities, such as the DIGESTIVE TRACT, the RESPIRATORY TRACT, and the reproductive tract. Mucosa, rich in blood and lymph vessels, comprises an inner epithelium, a middle layer (lamina propria) of loose CONNECTIVE TISSUE, and an outer layer (muscularis mucosae) of SMOOTH MUSCLE CELLS that separates the mucosa from submucosa.

Stratified squamous epithelium that covers the outer surface of the CORNEA. It is smooth and contains many free nerve endings.

The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.

The physical or physiological processes by which substances, tissue, cells, etc. take up or take in other substances or energy.

Microscopy of specimens stained with fluorescent dye (usually fluorescein isothiocyanate) or of naturally fluorescent materials, which emit light when exposed to ultraviolet or blue light. Immunofluorescence microscopy utilizes antibodies that are labeled with fluorescent dye.

The sequential location of genes on a chromosome.

Specialized non-fenestrated tightly-joined ENDOTHELIAL CELLS with TIGHT JUNCTIONS that form a transport barrier for certain substances between the cerebral capillaries and the BRAIN tissue.

The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.

Small polyhedral outpouchings along the walls of the alveolar sacs, alveolar ducts and terminal bronchioles through the walls of which gas exchange between alveolar air and pulmonary capillary blood takes place.

Proteins obtained from the ZEBRAFISH. Many of the proteins in this species have been the subject of studies involving basic embryological development (EMBRYOLOGY).

Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.

Calcium-dependent cell adhesion proteins. They are important in the formation of ADHERENS JUNCTIONS between cells. Cadherins are classified by their distinct immunological and tissue specificities, either by letters (E- for epithelial, N- for neural, and P- for placental cadherins) or by numbers (cadherin-12 or N-cadherin 2 for brain-cadherin). Cadherins promote cell adhesion via a homophilic mechanism as in the construction of tissues and of the whole animal body.

A carcinoma discovered by Dr. Margaret R. Lewis of the Wistar Institute in 1951. This tumor originated spontaneously as a carcinoma of the lung of a C57BL mouse. The tumor does not appear to be grossly hemorrhagic and the majority of the tumor tissue is a semifirm homogeneous mass. (From Cancer Chemother Rep 2 1972 Nov;(3)1:325) It is also called 3LL and LLC and is used as a transplantable malignancy.

Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.

An exotic species of the family CYPRINIDAE, originally from Asia, that has been introduced in North America. They are used in embryological studies and to study the effects of certain chemicals on development.

The process of moving proteins from one cellular compartment (including extracellular) to another by various sorting and transport mechanisms such as gated transport, protein translocation, and vesicular transport.

A light microscopic technique in which only a small spot is illuminated and observed at a time. An image is constructed through point-by-point scanning of the field in this manner. Light sources may be conventional or laser, and fluorescence or transmitted observations are possible.

A cell line derived from cultured tumor cells.

Interruption or suppression of the expression of a gene at transcriptional or translational levels.

Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.

The process of germ cell development in the male from the primordial germ cells, through SPERMATOGONIA; SPERMATOCYTES; SPERMATIDS; to the mature haploid SPERMATOZOA.

Immunologic method used for detecting or quantifying immunoreactive substances. The substance is identified by first immobilizing it by blotting onto a membrane and then tagging it with labeled antibodies.

The pattern of GENE EXPRESSION at the level of genetic transcription in a specific organism or under specific circumstances in specific cells.

Orientation of intracellular structures especially with respect to the apical and basolateral domains of the plasma membrane. Polarized cells must direct proteins from the Golgi apparatus to the appropriate domain since tight junctions prevent proteins from diffusing between the two domains.

The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.

A set of genes descended by duplication and variation from some ancestral gene. Such genes may be clustered together on the same chromosome or dispersed on different chromosomes. Examples of multigene families include those that encode the hemoglobins, immunoglobulins, histocompatibility antigens, actins, tubulins, keratins, collagens, heat shock proteins, salivary glue proteins, chorion proteins, cuticle proteins, yolk proteins, and phaseolins, as well as histones, ribosomal RNA, and transfer RNA genes. The latter three are examples of reiterated genes, where hundreds of identical genes are present in a tandem array. (King & Stanfield, A Dictionary of Genetics, 4th ed)

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.

Refers to animals in the period of time just after birth.

Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.

Methods used for detecting the amplified DNA products from the polymerase chain reaction as they accumulate instead of at the end of the reaction.

The relationships of groups of organisms as reflected by their genetic makeup.

A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.

Highly specialized EPITHELIAL CELLS that line the HEART; BLOOD VESSELS; and lymph vessels, forming the ENDOTHELIUM. They are polygonal in shape and joined together by TIGHT JUNCTIONS. The tight junctions allow for variable permeability to specific macromolecules that are transported across the endothelial layer.

The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.

Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.

Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.

MAMMARY GLANDS in the non-human MAMMALS.

A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)

Surface ligands, usually glycoproteins, that mediate cell-to-cell adhesion. Their functions include the assembly and interconnection of various vertebrate systems, as well as maintenance of tissue integration, wound healing, morphogenic movements, cellular migrations, and metastasis.

A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.

Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.

Tumors or cancer of the human BREAST.

A set of statistical methods used to group variables or observations into strongly inter-related subgroups. In epidemiology, it may be used to analyze a closely grouped series of events or cases of disease or other health-related phenomenon with well-defined distribution patterns in relation to time or place or both.

Adherence of cells to surfaces or to other cells.

The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.

Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.

A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.

Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).

All of the processes involved in increasing CELL NUMBER including CELL DIVISION.

Laboratory tests used to evaluate how well the kidneys are working through examination of blood and urine.

Proteins prepared by recombinant DNA technology.

Transmembrane proteins in the tight junction barrier. (1/304)

Three types of transmembrane proteins have been identified within the tight junction, but it remains to be determined how they provide the molecular basis for regulating the paracellular permeability for water, solutes, and immune cells. Several of these proteins localize specifically within the continuous cell-to-cell contacts of the tight junction. One of these, occludin, is a cell adhesion molecule that has been demonstrated to influence ion and solute permeability. The claudins are a family of four-membrane spanning proteins; unexpectedly, other members of this family have already been characterized without recognizing their relationship to tight junctions. Junction adhesion molecule, the most recently identified tight junction component, is a member of the Ig superfamily and influences the paracellular transmigration of immune cells. A plaque of cytoplasmic proteins under the junction may be responsible for scaffolding the transmembrane proteins, creating a link to the perijunctional actin cytoskeleton and transducing regulatory signals that control the paracellular barrier. (+info)

Der p 1 facilitates transepithelial allergen delivery by disruption of tight junctions. (2/304)

House dust mite (HDM) allergens are important factors in the increasing prevalence of asthma. The lung epithelium forms a barrier that allergens must cross before they can cause sensitization. However, the mechanisms involved are unknown. Here we show that the cysteine proteinase allergen Der p 1 from fecal pellets of the HDM Dermatophagoides pteronyssinus causes disruption of intercellular tight junctions (TJs), which are the principal components of the epithelial paracellular permeability barrier. In confluent airway epithelial cells, Der p 1 led to cleavage of the TJ adhesion protein occludin. Cleavage was attenuated by antipain, but not by inhibitors of serine, aspartic, or matrix metalloproteinases. Putative Der p 1 cleavage sites were found in peptides from an extracellular domain of occludin and in the TJ adhesion protein claudin-1. TJ breakdown nonspecifically increased epithelial permeability, allowing Der p 1 to cross the epithelial barrier. Thus, transepithelial movement of Der p 1 to dendritic antigen-presenting cells via the paracellular pathway may be promoted by the allergen's own proteolytic activity. These results suggest that opening of TJs by environmental proteinases may be the initial step in the development of asthma to a variety of allergens. (+info)

Connexin-occludin chimeras containing the ZO-binding domain of occludin localize at MDCK tight junctions and NRK cell contacts. (3/304)

Occludin is a transmembrane protein of the tight junction that functions in creating both an intercellular permeability barrier and an intramembrane diffusion barrier. Creation of the barrier requires the precise localization of occludin, and a distinct family of transmembrane proteins called claudins, into continuous linear fibrils visible by freeze-fracture microscopy. Conflicting evidence exists regarding the relative importance of the transmembrane and extracellular versus the cytoplasmic domains in localizing occludin in fibrils. To specifically address whether occludin's COOH-terminal cytoplasmic domain is sufficient to target it into tight junction fibrils, we created chimeras with the transmembrane portions of connexin 32. Despite the gap junction targeting information present in their transmembrane and extracellular domains, these connexin-occludin chimeras localized within fibrils when expressed in MDCK cells, as assessed by immunofluorescence and immunogold freeze-fracture imaging. Localization of chimeras at tight junctions depends on the COOH-terminal ZO-binding domain and not on the membrane proximal domain of occludin. Furthermore, neither endogenous occludin nor claudin is required for targeting to ZO-1-containing cell-cell contacts, since in normal rat kidney fibroblasts targeting of chimeras again required only the ZO-binding domain. These results suggest an important role for cytoplasmic proteins, presumably ZO-1, ZO-2, and ZO-3, in localizing occludin in tight junction fibrils. Such a scaffolding and cytoskeletal coupling function for ZO MAGUKs is analogous to that of other members of the MAGUK family. (+info)

Ca(2+)-independent cell-adhesion activity of claudins, a family of integral membrane proteins localized at tight junctions. (4/304)

In multicellular organisms, various compositionally distinct fluid compartments are established by epithelial and endothelial cellular sheets. For these cells to function as barriers, tight junctions (TJs) are considered to create a primary barrier for the diffusion of solutes through the paracellular pathway [1] [2] [3]. In ultrathin sections viewed under electron microscopy, TJs appear as a series of apparent fusions, involving the outer leaflets of plasma membranes of adjacent cells, to form the so-called kissing points of TJs, where the intercellular space is completely obliterated [4]. Claudins are a family of 16 proteins whose members have been identified as major integral membrane proteins localized exclusively at TJs [5] [6] [7] [8]. It remains unclear, however, whether claudins have the cell-adhesion activity that would explain the unusual intercellular adhesion at TJs. Using mouse L-fibroblast transfectants expressing various amounts of claudin-1, -2 or -3, we found that these claudins possess Ca(2+)-independent cell-adhesion activity. Using ultrathin-section electron microscopy, we observed many kissing points of TJs between adjacent transfectants. Furthermore, the cell-adhesion activity of occludin, another integral membrane protein localized at TJs [9] [10] [11], was negligible when compared with that of claudins. Thus, claudins are responsible for TJ-specific obliteration of the intercellular space. (+info)

Clostridium perfringens enterotoxin fragment removes specific claudins from tight junction strands: Evidence for direct involvement of claudins in tight junction barrier. (5/304)

Claudins, comprising a multigene family, constitute tight junction (TJ) strands. Clostridium perfringens enterotoxin (CPE), a single approximately 35-kD polypeptide, was reported to specifically bind to claudin-3/RVP1 and claudin-4/CPE-R at its COOH-terminal half. We examined the effects of the COOH-terminal half fragment of CPE (C-CPE) on TJs in L transfectants expressing claudin-1 to -4 (C1L to C4L, respectively), and in MDCK I cells expressing claudin-1 and -4. C-CPE bound to claudin-3 and -4 with high affinity, but not to claudin-1 or -2. In the presence of C-CPE, reconstituted TJ strands in C3L cells gradually disintegrated and disappeared from their cell surface. In MDCK I cells incubated with C-CPE, claudin-4 was selectively removed from TJs with its concomitant degradation. At 4 h after incubation with C-CPE, TJ strands were disintegrated, and the number of TJ strands and the complexity of their network were markedly decreased. In good agreement with the time course of these morphological changes, the TJ barrier (TER and paracellular flux) of MDCK I cells was downregulated by C-CPE in a dose-dependent manner. These findings provided evidence for the direct involvement of claudins in the barrier functions of TJs. (+info)

Manner of interaction of heterogeneous claudin species within and between tight junction strands. (6/304)

In tight junctions (TJs), TJ strands are associated laterally with those of adjacent cells to form paired strands to eliminate the extracellular space. Claudin-1 and -2, integral membrane proteins of TJs, reconstitute paired TJ strands when transfected into L fibroblasts. Claudins comprise a multigene family and more than two distinct claudins are coexpressed in single cells, raising the questions of whether heterogeneous claudins form heteromeric TJ strands and whether claudins interact between each of the paired strands in a heterophilic manner. To answer these questions, we cotransfected two of claudin-1, -2, and -3 into L cells, and detected their coconcentration at cell-cell borders as elaborate networks. Immunoreplica EM confirmed that distinct claudins were coincorporated into individual TJ strands. Next, two L transfectants singly expressing claudin-1, -2, or -3 were cocultured and we found that claudin-3 strands laterally associated with claudin-1 and -2 strands to form paired strands, whereas claudin-1 strands did not interact with claudin-2 strands. We concluded that distinct species of claudins can interact within and between TJ strands, except in some combinations. This mode of assembly of claudins could increase the diversity of the structure and functions of TJ strands. (+info)

Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins. (7/304)

ZO-1, ZO-2, and ZO-3, which contain three PDZ domains (PDZ1 to -3), are concentrated at tight junctions (TJs) in epithelial cells. TJ strands are mainly composed of two distinct types of four-transmembrane proteins, occludin, and claudins, between which occludin was reported to directly bind to ZO-1/ZO-2/ZO-3. However, in occludin-deficient intestinal epithelial cells, ZO-1/ZO-2/ZO-3 were still recruited to TJs. We then examined the possible interactions between ZO-1/ZO-2/ZO-3 and claudins. ZO-1, ZO-2, and ZO-3 bound to the COOH-terminal YV sequence of claudin-1 to -8 through their PDZ1 domains in vitro. Then, claudin-1 or -2 was transfected into L fibroblasts, which express ZO-1 but not ZO-2 or ZO-3. Claudin-1 and -2 were concentrated at cell-cell borders in an elaborate network pattern, to which endogenous ZO-1 was recruited. When ZO-2 or ZO-3 were further transfected, both were recruited to the claudin-based networks together with endogenous ZO-1. Detailed analyses showed that ZO-2 and ZO-3 are recruited to the claudin-based networks through PDZ2 (ZO-2 or ZO-3)/PDZ2 (endogenous ZO-1) and PDZ1 (ZO-2 or ZO-3)/COOH-terminal YV (claudins) interactions. In good agreement, PDZ1 and PDZ2 domains of ZO-1/ZO-2/ZO-3 were also recruited to claudin-based TJs, when introduced into cultured epithelial cells. The possible molecular architecture of TJ plaque structures is discussed. (+info)

Oncogenic Raf-1 disrupts epithelial tight junctions via downregulation of occludin. (8/304)

Occludin is an integral membrane protein of the epithelial cell tight junction (TJ). Its potential role in coordinating structural and functional events of TJ formation has been suggested recently. Using a rat salivary gland epithelial cell line (Pa-4) as a model system, we have demonstrated that occludin not only is a critical component of functional TJs but also controls the phenotypic changes associated with epithelium oncogenesis. Transfection of an oncogenic Raf-1 into Pa-4 cells resulted in a complete loss of TJ function and the acquisition of a stratified phenotype that lacked cell-cell contact growth control. The expression of occludin and claudin-1 was downregulated, and the distribution patterns of ZO-1 and E-cadherin were altered. Introduction of the human occludin gene into Raf-1-activated Pa-4 cells resulted in reacquisition of a monolayer phenotype and the formation of functionally intact TJs. In addition, the presence of exogenous occludin protein led to a recovery in claudin-1 protein level, relocation of the zonula occludens 1 protein (ZO-1) to the TJ, and redistribution of E-cadherin to the lateral membrane. Furthermore, the expression of occludin inhibited anchorage-independent growth of Raf-1-activated Pa-4 cells in soft agarose. Thus, occludin may act as a pivotal signaling molecule in oncogenic Raf- 1-induced disruption of TJs, and regulates phenotypic changes associated with epithelial cell transformation. (+info)

... (c. 1490 - 13 October 1562) was a French composer of the Renaissance. Along with Clément Janequin he was one ... Free scores by Claudin de Sermisy at the International Music Score Library Project (IMSLP) Tant que vivray midi file ... ISBN 0-89917-034-X Isabelle Cazeaux, "Claudin de Sermisy", The New Grove Dictionary of Music and Musicians, ed. Stanley Sadie. ... 1527) Tu disais que j'en mourrais Vignon, vignon, vignon, vignette Vive la serpe Aspice, Domine Isabelle Cazeaux, "Claudin d ...

https://en.wikipedia.org/wiki/Claudin_de_Sermisy

Claudin, P; Andreotti, B (2006). "A scaling law for aeolian dunes on Mars, Venus, Earth, and for subaqueous ripples". Earth and ... Chang, Kenneth (October 1, 2013). "Hitting Pay Dirt on Mars". New York Times. Retrieved October 2, 2013. Meslin, P.-Y.; Forni, ... 252 (1-2): 30-44. arXiv:cond-mat/0603656. Bibcode:2006E&PSL.252...30C. doi:10.1016/j.epsl.2006.09.004. S2CID 13910286. Sullivan ... Logan, Bruce E; Wu, Jun; Unz, Richard F (August 1, 2001). "Biological Perchlorate Reduction in High-Salinity Solutions". Water ...

https://en.wikipedia.org/wiki/Martian_soil

Bordiec, M.; Carpy, S.; Bourgeois, O.; Herny, C.; Massé, M.; Perret, L.; Claudin, P.; Pochat, S.; Douté, S. (1 December 2020 ... Only about 1% of Antarctic ice area can be considered to be blue-ice area, but they have attracted scientific interest due to ... Blue-ice areas make up only about 1% of the Antarctic surface ice; however, they are locally common and scattered across the ... doi:10.1111/j.1945-5100.2001.tb01918.x. Harvey, Ralph (1 January 2003). "The Origin and Significance of Antarctic Meteorites". ...

https://en.wikipedia.org/wiki/Blue-ice_area

Claudin, Philippe; Andreotti, Bruno (2006). "A scaling law for aeolian dunes on Mars, Venus, Earth, and for subaqueous ripples ... 1 m in amplitude. Understanding TAR formation and evolution could offer insight into the winds that created them. In turn, ... 252 (1-2): 30-44. arXiv:cond-mat/0603656. Bibcode:2006E&PSL.252...30C. doi:10.1016/j.epsl.2006.09.004. ISSN 0012-821X. S2CID ... 1-162, doi:10.1130/mem72-p1, hdl:2027/osu.32435000785121, retrieved 2020-09-15 G. Kocurek, M. Townsley, E. Yeh, K. (1992). " ...

https://en.wikipedia.org/wiki/Transverse_aeolian_ridges

Claudin, A. (1894). Les Origines de l'imprimerie à Saint-Lô en Normandie [The origins of printing at Saint-Lô in Normandy] (in ... French). Paris: A. Claudin. Le Clerc, R. (1930). Histoire du Bon Sauveur de Saint-Lô [History of the Bon Sauveur of Saint-Lô] ( ... It is also chef-lieu of an arrondissement and two cantons (Saint-Lô-1 and Saint-Lô-2). The placename derives from that of a ... 1, 1857 Lepingard, Édouard (1866). "Une page de l'histoire de Saint-Lô". Annuaire du Département de la Manche. Miniac, Jean- ...

https://en.wikipedia.org/wiki/Saint-Lô

In mice, Claudin-5 loss during development is lethal and results in size-selective loosening of the BBB. The blood-brain ... February 2018). "claudin 5". Biology Open. 7 (2): bio030494. doi:10.1242/bio.030494. PMC 5861362. PMID 29437557. Abbott NJ, ... May 2003). "Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice". The Journal of Cell Biology. 161 ... such as Claudin-5), junctional adhesion molecule (such as JAM-A). Each of these tight junction proteins is stabilized to the ...

https://en.wikipedia.org/wiki/Blood–brain_barrier

The name claudin comes from Latin word claudere ("to close"), suggesting the barrier role of these proteins. A recent review ... A Chimeric Claudin was synthesized to help enhance the understanding of both the structure and function of the tight junction. ... All human claudins (with the exception of Claudin 12) have domains that let them bind to PDZ domains of scaffold proteins. The ... There are 23 genes found in the human genome for claudin proteins and there are 27 transmembrane domains across mammals. The ...

https://en.wikipedia.org/wiki/Claudin

Van Itallie CM, Mitic LL, Anderson JM (July 2012). "SUMOylation of claudin-2". Annals of the New York Academy of Sciences. 1258 ... 374 (Pt 1): 1-20. doi:10.1042/BJ20030407. PMC 1223585. PMID 12773095. Liu B, Gross M, ten Hoeve J, Shuai K (March 2001). "A ... 554 (1-2): 111-8. doi:10.1016/s0014-5793(03)01116-5. PMID 14596924. S2CID 23261716. Wong KA, Kim R, Christofk H, Gao J, Lawson ... 229 (1-2): 109-16. doi:10.1016/s0378-1119(99)00033-5. PMID 10095110. Betz A, Lampen N, Martinek S, Young MW, Darnell JE (August ...

https://en.wikipedia.org/wiki/Protein_inhibitor_of_activated_STAT

Claudin-12 is a protein that in humans is encoded by the CLDN12 gene. It belongs to the group of claudins. GRCh38: Ensembl ... "Entrez Gene: CLDN12 claudin 12". Human CLDN12 genome location and CLDN12 gene details page in the UCSC Genome Browser. Kniesel ... 2001). "claudin-18, a novel downstream target gene for the T/EBP/NKX2.1 homeodomain transcription factor, encodes lung- and ... Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): ...

https://en.wikipedia.org/wiki/CLDN12

Claudin-20 is a protein that in humans is encoded by the CLDN20 gene. It belongs to the group of claudins. GRCh38: Ensembl ... "Entrez Gene: CLDN20 claudin 20". Human CLDN20 genome location and CLDN20 gene details page in the UCSC Genome Browser. Kniesel ... Hewitt KJ, Agarwal R, Morin PJ (Aug 2006). "The claudin gene family: expression in normal and neoplastic tissues". BMC Cancer. ... Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): ...

https://en.wikipedia.org/wiki/CLDN20

Claudin-17 is a protein that in humans is encoded by the CLDN17 gene. It belongs to the group of claudins; claudins are cell- ... Claudin-17 Deficiency in Mice Results in Kidney Injury Due to Electrolyte Imbalance and Oxidative Stress. Cells. 2022 May 29;11 ... "Entrez Gene: CLDN17 claudin 17". Adil, MS; Narayanan, SP; Somanath, PR (2021). "Cell-cell junctions: structure and regulation ... Krug SM, Günzel D, Conrad MP, Rosenthal R, Fromm A, Amasheh S, Schulzke JD, Fromm M (2012). "Claudin-17 forms tight junction ...

https://en.wikipedia.org/wiki/CLDN17

Claudin-14 is a protein that in humans is encoded by the CLDN14 gene. It belongs to a related family of proteins called ... "Entrez Gene: CLDN14 claudin 14". Baker M, Reynolds LE, Robinson SD, Lees DM, Parsons M, Elia G, et al. (2013). "Stromal ... Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): ... Sticky cells, blood vessels and cancer - the paradox of Claudin-14 - Marianne Baker, Cancer Research UK Science Update blog, 14 ...

https://en.wikipedia.org/wiki/CLDN14

Claudin-7 is a protein that in humans is encoded by the CLDN7 gene. It belongs to the group of claudins. Claudins, such as ... "Entrez Gene: CLDN7 claudin 7". Human CLDN7 genome location and CLDN7 gene details page in the UCSC Genome Browser. Kniesel U, ... 2005). "Claudin-1 is a strong prognostic indicator in stage II colonic cancer: a tissue microarray study". Mod. Pathol. 18 (4 ... 2003). "Loss of the tight junction protein claudin-7 correlates with histological grade in both ductal carcinoma in situ and ...

https://en.wikipedia.org/wiki/CLDN7

"Entrez Gene: CLDN9 claudin 9". Higashi AY, Higashi T, Furuse K, Ozeki K, Furuse M, Chiba H (Nov 2021). "Claudin-9 constitutes ... 2007). "Claudin-6 and claudin-9 function as additional coreceptors for hepatitis C virus". J. Virol. 81 (22): 12465-71. doi: ... Claudin-9 is a protein that in humans is encoded by the CLDN9 gene. It belongs to the group of claudins. This gene is expressed ... Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): ...

https://en.wikipedia.org/wiki/CLDN9

Claudin-1 is a protein that in humans is encoded by the CLDN1 gene. It belongs to the group of claudins. Tight junctions ... "Entrez Gene: CLDN1 claudin 1". Coyne CB, Gambling TM, Boucher RC, Carson JL, Johnson LG (Nov 2003). "Role of claudin ... The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight ... Miyamori H, Takino T, Kobayashi Y, Tokai H, Itoh Y, Seiki M, Sato H (2001). "Claudin promotes activation of pro-matrix ...

https://en.wikipedia.org/wiki/CLDN1

Claudin-8 is a protein that in humans is encoded by the CLDN8 gene. It belongs to the group of claudins. GRCh38: Ensembl ... "Entrez Gene: CLDN8 claudin 8". Human CLDN8 genome location and CLDN8 gene details page in the UCSC Genome Browser. Kniesel U, ... Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): ... Morita K, Furuse M, Fujimoto K, Tsukita S (Mar 1999). "Claudin multigene family encoding four-transmembrane domain protein ...

https://en.wikipedia.org/wiki/CLDN8

Claudin-22 is a protein that in humans is encoded by the CLDN22 gene. It belongs to the group of claudins. GRCh38: Ensembl ... "Entrez Gene: CLDN22 claudin 22". Human CLDN22 genome location and CLDN22 gene details page in the UCSC Genome Browser. González ... Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): ... Heiskala M, Peterson PA, Yang Y (2001). "The roles of claudin superfamily proteins in paracellular transport". Traffic. 2 (2): ...

https://en.wikipedia.org/wiki/CLDN22

Claudin-16 is a protein that in humans is encoded by the CLDN16 gene. It belongs to the group of claudins. Tight junctions ... The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight ... 2004). "A Novel Claudin 16 Mutation Associated with Childhood Hypercalciuria Abolishes Binding to ZO-1 and Results in Lysosomal ... "Entrez Gene: CLDN16 claudin 16". "Salmonella infection data for Cldn16". Wellcome Trust Sanger Institute. "Citrobacter ...

https://en.wikipedia.org/wiki/CLDN16

Claudin domain-containing protein 1 is a protein that in humans is encoded by the CLDND1 gene. GRCh38: Ensembl release 89: ... "Entrez Gene: CLDND1 claudin domain containing 1". Human CLDND1 genome location and CLDND1 gene details page in the UCSC Genome ... 289 (1-2): 119-29. doi:10.1016/S0378-1119(02)00507-3. PMID 12036590. Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and ...

https://en.wikipedia.org/wiki/CLDND1

"Entrez Gene: CLDN4 claudin 4". Ohta Y, Sasaki Y, Saito M, Kushima M, Takimoto M, Shiokawa A, Ota H (2013). "Claudin-4 as a ... Claudin 4, also known as CLDN4, is a protein which in humans is encoded by the CLDN4 gene. It belongs to the group of claudins ... Claudin 4 can also be used as a marker for distinguishing malignant mesothelioma from lung cancer and uterine serous carcinoma ... Ohta Y, Sasaki Y, Saito M, Kushima M, Takimoto M, Shiokawa A, Ota H (2013). "Claudin-4 as a marker for distinguishing malignant ...

https://en.wikipedia.org/wiki/CLDN4

"Claudin-1 overexpression effect on lung adenocarcinoma cell line". NCBI GEO Profiles. Retrieved 4 May 2015. Vandepoele K, Van ... Neuroblastoma breakpoint family, member 1, or NBPF1, is a protein that is encoded by the gene NBPF1 in humans. This protein is ... The NBPF1 protein is also found to be disrupted by a chromosomal translocation between chromosomes 1 and 17 with in some cases ... Additionally, the inactivation of Far upstream element-binding protein 1 causes a decrease in NBPF1, while the inactivation of ...

https://en.wikipedia.org/wiki/NBPF1

Claudin-5 is a protein that in humans is encoded by the CLDN5 gene. It belongs to the group of claudins. This gene encodes a ... "Entrez Gene: CLDN5 claudin 5 (transmembrane protein deleted in velocardiofacial syndrome)". Coyne CB, Gambling TM, Boucher RC, ... Kojima S, Rahner C, Peng S, Rizzolo LJ (2002). "Claudin 5 is transiently expressed during the development of the retinal ... Tsukita S, Furuse M (2002). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): ...

https://en.wikipedia.org/wiki/CLDN5

It caused by mutations in the Claudin 1 gene. Ichthyosis prematurity syndrome List of cutaneous conditions Rapini, Ronald P.; ... ISBN 978-1-4160-2999-1. "Ichthyosis, leukocyte vacuoles, alopecia, and sclerosing cholangitis - About the Disease - Genetic and ...

https://en.wikipedia.org/wiki/Neonatal_ichthyosis–sclerosing_cholangitis_syndrome

Claudin-11 is a protein that in humans is encoded by the CLDN11 gene. It belongs to the group of claudins and was the first ... "Entrez Gene: CLDN11 claudin 11 (oligodendrocyte transmembrane protein)". Gow A, Southwood CM, Li JS, Pariali M, Riordan GP, ... The protein encoded by this gene belongs to the claudin family of tight junction associated proteins and is a major component ... Tiwari-Woodruff SK, Buznikov AG, Vu TQ, Micevych PE, Chen K, Kornblum HI, Bronstein JM (April 2001). "OSP/claudin-11 forms a ...

https://en.wikipedia.org/wiki/CLDN11

Claudin 3, also known as CLDN3, is a protein which in humans is encoded by the CLDN3 gene. It is a member of the claudin ... "Entrez Gene: CLDN3 claudin 3". Coyne CB, Gambling TM, Boucher RC, Carson JL, Johnson LG (Nov 2003). "Role of claudin ... "Expression of Clostridium perfringens enterotoxin receptors claudin-3 and claudin-4 in prostate cancer epithelium". Cancer Res ... The protein encoded by this intron-less gene, a member of the claudin family, is an integral membrane protein and a component ...

https://en.wikipedia.org/wiki/CLDN3

"Entrez Gene: CLDN18 claudin 18". Niimi T, Nagashima K, Ward JM, et al. (2001). "claudin-18, a Novel Downstream Target Gene for ... Claudin 18.2) is abundant in gastric tumors. Experimental antibody IMAB362 targets Claudin 18.2 to help treat gastric cancers. ... Claudin-18 is a protein that in humans is encoded by the CLDN18 gene. It belongs to the group of claudins. CLDN18 belongs to ... Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): ...

https://en.wikipedia.org/wiki/CLDN18

Claudin-19 is a protein that in humans is encoded by the CLDN19 gene. It belongs to the group of claudins. Claudin-19 has been ... "Entrez Gene: CLDN19 claudin 19". Naeem, M.; Hussain, S.; Akhtar, N. (2011). "Mutation in the Tight-Junction Gene Claudin 19 ( ... 2006). "Kidney claudin-19: localization in distal tubules and collecting ducts and dysregulation in polycystic renal disease". ... Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): ...

https://en.wikipedia.org/wiki/CLDN19

Claudin-15 is a protein that in humans is encoded by the CLDN15 gene. It belongs to the group of claudins. Among its related ... "Entrez Gene: CLDN15 claudin 15". Database, GeneCards Human Gene. "CLDN15 Gene - GeneCards , CLD15 Protein , CLD15 Antibody". ... Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): ... Heiskala M, Peterson PA, Yang Y (2001). "The roles of claudin superfamily proteins in paracellular transport". Traffic. 2 (2): ...

https://en.wikipedia.org/wiki/CLDN15

Claudin-2 is a protein that in humans is encoded by the CLDN2 gene. It belongs to the group of claudins. Members of the claudin ... Claudin-2 is expressed in cation-leaky epithelia such as that of the kidney proximal tubule. Mice that are deficient in claudin ... "Entrez Gene: CLDN2 claudin 2". Muto, S.; Hata, M.; Taniguchi, J.; Tsuruoka, S.; Moriwaki, K.; Saitou, M.; Furuse, K.; Sasaki, H ... 1998). "Claudin-1 and -2: Novel Integral Membrane Proteins Localizing at Tight Junctions with No Sequence Similarity to ...

https://en.wikipedia.org/wiki/CLDN2

Jia, P.; B. Andreotti; P. Claudin (March 2017). "Giant ripples on comet 67P/Churyumov-Gerasimenko sculpted by sunset thermal ... Hayes, A.G. (1 June 2018). "Dunes across the Solar System". Science. 360 (6392): 960-961. Bibcode:2018Sci...360..960H. doi: ... 1 June 2018). "Dunes on Pluto". Science. 360 (6392): 992-997. Bibcode:2018Sci...360..992T. doi:10.1126/science.aao2975. PMID ... spaced about 0.4 to 1 km apart, that are thought to be composed of 200-300 μm diameter particles of methane ice believed to be ...

https://en.wikipedia.org/wiki/List_of_extraterrestrial_dune_fields

Cates, M. E.; Wittmer, J. P.; Bouchaud, J.-P.; Claudin, P. (31 August 1998). "Jamming, Force Chains, and Fragile Matter". ... He is the 19th Lucasian Professor of Mathematics at the University of Cambridge and has held this position since 1 July 2015. ...

https://en.wikipedia.org/wiki/Michael_Cates

ISBN 2710330733 Eugène de Mirecourt, Méry (1858) Text online Gustave Claudin, Méry : sa vie intime, anecdotique et littéraire ( ... Méry, The Tower of Destiny, ISBN 978-1-61227-101-9. Works by Joseph Méry at Project Gutenberg Works by Joseph Méry at Faded ... Text online 1 2 Le Siège de Marseille par le connétable de Bourbon, chronique du XVIe (1841) Anglais et Chinois (1843) Text ... Text online 1 2 Un amour dans le crime (2 volumes, 1854) Une histoire de famille (2 volumes, 1854) Le Paradis terrestre (2 ...

https://en.wikipedia.org/wiki/Joseph_Méry

These complexes, formed primarily of members of the claudin and the occludin families, consist of about 35 different proteins, ... 124 (1): 3-22. doi:10.1016/j.jaci.2009.05.038. ISSN 0091-6749. PMC 4266989. PMID 19560575. Bennett, M. V.; Barrio, L. C.; ... Geibel, John P. (1 January 2005). "Secretion and absorption by colonic crypts". Annual Review of Physiology. 67: 471-490. doi: ... 92 (1-2): 256-262. doi:10.1016/j.physbeh.2007.05.017. ISSN 0031-9384. PMID 17582445. S2CID 230872. Cario, E (2010). "Heads up! ...

https://en.wikipedia.org/wiki/Intestinal_epithelium

... is concentrated at tight junctions through its possible interaction with claudin-1 and junctional adhesion molecule". The ... 1 (3): 287-92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614. Ebnet K, Suzuki A, Horikoshi Y, Hirose T, Meyer Zu ... 277 (1): 455-61. doi:10.1074/jbc.M109005200. PMID 11689568. KDR+protein,+human at the US National Library of Medicine Medical ... 310 ( Pt 1) (1): 155-62. doi:10.1042/bj3100155. PMC 1135867. PMID 7646439. "Entrez Gene: F11R F11 receptor". Ebnet K, Schulz CU ...

https://en.wikipedia.org/wiki/F11_receptor

... has overexpressed HER2/neu Normal breast-like Claudin-low: a more recently described class; often triple-negative, but distinct ... 1 point: tubular formation in more than 75% of the tumor (it may in addition be termed "majority of tumor") 2 points: tubular ... 1 point: nuclei with minimal or mild variation in size and shape 2 points: nuclei with moderate variation in size and shape 3 ... 13 (1): 2-7. doi:10.2325/jbcs.13.2. PMID 16518056. S2CID 6255927. Normanno N, De Luca A, Carotenuto P, Lamura L, Oliva I, ...

https://en.wikipedia.org/wiki/Breast_cancer_classification

Claudin E is a molecule found in tight junctions that appears to be expressed in the EVL and required for normal zebrafish ... "The tight junction component claudin E is required for zebra fish epiboly". Developmental Dynamics. 239 (2): 715-722. doi: ... 124 (1): 269-80. doi:10.1016/0012-1606(87)90478-7. PMID 3666309. C.B. Kimmel; R.M. Warga; T.F. Schilling (1990-04-01). "Origin ... 83 (1-2): 77-94. doi:10.1016/S0925-4773(99)00036-2. PMID 10381569. Conway G, Margoliath A, Wong-Madden S, Roberts RJ, Gilbert W ...

https://en.wikipedia.org/wiki/Epiboly

Markov AG, Falchuk EL, Kruglova NM, Radloff J, Amasheh S (January 2016). "Claudin expression in follicle-associated epithelium ... 216 (1): 13-4. doi:10.1111/apha.12595. PMID 26335934. Pascall, C R; Stearn, E J; Mosley, J G (1980-07-05), "Short Reports", ... From p. 6062: "As 1. Glandulae miliares of the small Guts, which may also in some Animals be well call'd fragi-formes, from the ... 216 (1): 112-9. doi:10.1111/apha.12559. hdl:11701/6438. PMID 26228735. S2CID 13389571. Lelouard H, Fallet M, de Bovis B, ...

https://en.wikipedia.org/wiki/Peyer's_patch

Claudin de Sermisy, Thomas Crecquillon, Domenico Ferrabosco, Jean de Latre, Jacquet de Berchem, Jakob Meiland, Alexander ... 300 R/Vv, 123". The codex, consisting of 183 folia, is bound in parchment with the initials "P W S P" and the number "1 5 9 1" ... 1. Schott Musik International. ISBN 3-7957-0531-2. Beckmann, Klaus (2001). Repertorium Orgelmusik 1150-2000 (in German). Vol. 1 ... ISBN 83-900905-1-1. Erdman, Jerzy (1997). Tabulatura Gdańska - The Gdańsk Tablature - 1591 (CD Recording). Polskie Nagrania. ...

https://en.wikipedia.org/wiki/Gdańsk_Tablature

"Systems Proteomics View of the Endogenous Human Claudin Protein Family". Journal of Proteome Research. 15 (2): 339-359. doi: ... 13 (1): 15-20. doi:10.1021/pr401144x. PMC 3928647. PMID 24364385. Liu, S; Im, H; Bairoch, A; Cristofanilli, M; Chen, R; Deutsch ... 12 (1): 45-57. doi:10.1021/pr300985j. PMC 4142220. PMID 23259914. "The Global Proteome Machine and Database". Retrieved 2014-09 ...

https://en.wikipedia.org/wiki/Ronald_Beavis

"Decreased lactate dehydrogenase B expression enhances claudin 1-mediated hepatoma cell invasiveness via mitochondrial defects ... 505 (1): 33-41. doi:10.1016/j.abb.2010.10.010. PMID 20951115. Zha X, Wang F, Wang Y, He S, Jing Y, Wu X, Zhang H (2011). " ... 71 (1): 13-8. doi:10.1158/0008-5472.CAN-10-1668. PMID 21199794. Kim JH, Kim EL, Lee YK, Park CB, Kim BW, Wang HJ, Yoon CH, Lee ... 117B (1): 11-7. doi:10.1002/ajmg.b.10015. PMID 12555229. S2CID 25994539. Mazzotta S, Guerranti R, Gozzetti A, Bucalossi A, ...

https://en.wikipedia.org/wiki/Lactate_dehydrogenase_b

MicroRNA Gong Y, Renigunta V, Himmerkus N, Zhang J, Renigunta A, Bleich M, Hou J (April 2012). "Claudin-14 regulates renal Ca ... 7 (1): e29837. Bibcode:2012PLoSO...729837M. doi:10.1371/journal.pone.0029837. PMC 3254631. PMID 22253797. Chang SJ, Weng SL, ...

https://en.wikipedia.org/wiki/Mir-374_microRNA_precursor_family

Claudin de Sermisy, French composer (b. 1495) October 18 - Anne d'Alençon, French noblewoman (b. 1492) November 7 - Maldeo ... March 1 - Over 80 (?) Huguenots are massacred by the ultra-Catholic Francis, Duke of Guise in Wassy-sur-Blaise, marking the ... May 1 - Jean Ribault, French navigator, lands in Florida, and later establishes a Huguenot colony at Charlesfort on Parris ... July 1 - Wilhelm IV of Eberstein, German President of the Reichskammergericht (b. 1497) July 4 - Johann Hommel, German ...

https://en.wikipedia.org/wiki/1562

1382/1383-1395) José Serebrier (born 1938) Claudin de Sermisy (c. 1490 - 1562) Kazimierz Serocki (1922-1981) Alexander Serov ( ... Retrieved 1 September 2020. (subscription or UK public library membership required) Arlt, Wulf [de] (2001). "Jehannot de ... Retrieved 1 September 2020. (subscription or UK public library membership required) Huglo, Michel (2001). "Stephen of Liège". ... Retrieved 1 September 2020. (subscription or UK public library membership required) Günther, Ursula (2001). "Vaillant, Jehan". ...

https://en.wikipedia.org/wiki/List_of_composers_by_name

Nevertheless, another sources document existence of mTEC unipotent progenitors that express claudin 3 and 4 (Cld3/4). These two ... "Medullary thymic epithelial cells expressing Aire represent a unique lineage derived from cells expressing claudin". Nature ... 140 (1): 123-35. doi:10.1016/j.cell.2009.12.030. PMID 20085707. Guha M, Saare M, Maslovskaja J, Kisand K, Liiv I, Haljasorg U, ... 5 (1): 166-79. doi:10.1016/j.celrep.2013.08.038. PMC 3820422. PMID 24095736. Gordon J, Wilson VA, Blair NF, Sheridan J, Farley ...

https://en.wikipedia.org/wiki/Medullary_thymic_epithelial_cells

ISBN 978-84-7222-878-8. Azcárate, Manuel; Fernando Claudin (1979). Marc Abeles; Charles-Albert Ryng (eds.). L'Europe de ... ISBN 978-1-78076-108-4. Retrieved 2015-11-29. Eaton, Samuel D. (1981). The Forces of Freedom in Spain 1974-1979: A Personal ... ISBN 978-1-4128-1999-2. Retrieved 2015-11-29. Bolloten, Burnett (1991). The Spanish Civil War: Revolution and Counterrevolution ... ISBN 1-134-55408-7. Retrieved 2015-11-29. Sánchez Cervelló, Josep; Agudo, Sebastián (2015-04-23). Las Brigadas Internacionales ...

https://en.wikipedia.org/wiki/Manuel_Azcárate

In the 16th century, Claudin de Sermisy set the psalm. In the 17th century, Henry Dumont set this psalm for La Chapelle Royale ... Verse 1 is the final verse of Nishmat. Verses 2, 10, and 13 are recited during Selichot. Verses 10, 13, and 14 are part of the ... ISBN 978-1-4411-3796-8. "10,000 Reasons". Word to Worship. Retrieved 23 June 2020. Miller, Patrick D. (2013). The Lord of the ... Verse 17 is quoted in Mary's song of praise, the Magnificat, in Luke 1:50. In the Western church, this psalm was traditionally ...

https://en.wikipedia.org/wiki/Psalm_103

... is concentrated at tight junctions through its possible interaction with claudin-1 and junctional adhesion molecule". J. Biol. ... 117 (1): 47-57. doi:10.1016/S0169-328X(03)00283-3. PMID 14499480. Krapivinsky G, Medina I, Krapivinsky L, Gapon S, Clapham DE ( ... 424 (1-2): 63-8. doi:10.1016/s0014-5793(98)00141-0. PMID 9537516. S2CID 25328791. Mancini A, Koch A, Stefan M, Niemann H, ... 424 (1-2): 63-8. doi:10.1016/S0014-5793(98)00141-0. PMID 9537516. S2CID 25328791. Barritt DS, Pearn MT, Zisch AH, Lee SS, ...

https://en.wikipedia.org/wiki/MPDZ

2 January 2020). "An RNA vaccine drives expansion and efficacy of claudin-CAR-T cells against solid tumors". Science. 367 (6476 ... "Claudin-18 splice variant 2 is a pan-cancer target suitable for therapeutic antibody development". Clinical Cancer Research. 14 ... Plus CAPOX Compared With Placebo Plus CAPOX as First-line Treatment of Subjects With Claudin (CLDN) 18.2-Positive, HER2- ... 1 September 2019). "A multicentre, phase IIa study of zolbetuximab as a single agent in patients with recurrent or refractory ...

https://en.wikipedia.org/wiki/Uğur_Şahin

"Tradition and Imitation in Pierre Certon's Déploration for Claudin de Sermisy". Revue de Musicologie. 85 (1): 29-62. doi: ... ISBN 978-1-5017-0486-4. Reese, Gustave (1940). Music in the Middle Ages: With an Introduction on the Music of Ancient Times. ... ISBN 978-1-137-27770-1. Wilkins, Nigel (1979). Music in the age of Chaucer. Cambridge: D.S. Brewer. ISBN 978-0-85991-052-1. ... ISBN 978-1-56159-263-0. Archived from the original on 1 June 2018. (subscription or UK public library membership required) Rice ...

https://en.wikipedia.org/wiki/F._Andrieu

Claudin-1 specifically prevents paracellular diffusion of small molecules through tight junctions in the epidermis. C11orf49 ... C11orf49 expression is significantly increased after the overexpression of claudin-1 in lung adenocarcinoma cell lines. ... C11orf49 expression is significantly increased after the overexpression of Claudin-1 in lung adenocarcinoma cells. C11orf49 ... Variant 1 lacks a 3' splice junction, which results in a truncated 3' terminus compared to variant 2. Variant 3 contains an ...

https://en.wikipedia.org/wiki/C11orf49

"Medullary thymic epithelial cells expressing Aire represent a unique lineage derived from cells expressing claudin". Nature ... 32 (1): 29-40. doi:10.1016/j.immuni.2009.10.009. ISSN 1074-7613. PMID 20045355. Takada, Kensuke; Van Laethem, Francois; Xing, ... 21 (1): 139-176. doi:10.1146/annurev.immunol.21.120601.141107. ISSN 0732-0582. PMID 12414722. Germain, Ronald N. (May 2002). "T ... 24 (1): 24-41. doi:10.1038/cr.2013.168. ISSN 1001-0602. PMC 3879710. PMID 24366339. Nedjic, Jelena; Aichinger, Martin; Emmerich ...

https://en.wikipedia.org/wiki/Cortical_thymic_epithelial_cells

... as well as production of epithelial proteins such as desmoplakin and claudin, and activate the expression of vimentin and ... 1). This is the main feature of this type of invasion, since the underlying cellular mechanisms are the same key processes that ... 1) in the case of single cell invasion. These transitions usually occur upon changes in the activity of certain cell molecules ... 1). In turn, the latter, in particular cells that have undergone EMT, are capable under certain conditions of gaining an ...

https://en.wikipedia.org/wiki/Invasion_(cancer)

Rabbit Polyclonal Claudin 1 antibody C-Term for IHC, WB. Order anti-Claudin 1 antibody ABIN2704650. ... Target Details for Claudin 1 (hide) Target Claudin 1 (CLDN1) Alternative Name Claudin 1 (CLDN1 Products) Synonyms CLD1, ILVASC ... anti-Claudin 1 (CLDN1) (AA 1-211) antibody CLDN1 Reactivity: Human IHC (p), IP, ELISA, WB Host: Mouse Monoclonal 1C5-D9 ... anti-Claudin 1 (CLDN1) (AA 1-211) antibody CLDN1 Reactivity: Human IF, IP, ELISA, WB Host: Mouse Monoclonal 2E2-H5 unconjugated ...

https://www.antibodies-online.com/antibody/2704650/anti-Claudin+1+CLDN1+C-Term+antibody/

ADAM15 mediates upregulation of Claudin-1 expression in breast cancer cells. Jens Mattern, Christian S. Roghi, Melanie Hurtz, ...

https://research-portal.uea.ac.uk/en/publications/adam15-mediates-upregulation-of-claudin-1-expression-in-breast-ca/persons/

Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry Share Share Share ... Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry ...

https://www.ndm.ox.ac.uk/publications/652205

T2 - Reductions in claudin-1 may enhance susceptibility to herpes simplex virus 1 infections in atopic dermatitis (Journal of ... Erratum: Reductions in claudin-1 may enhance susceptibility to herpes simplex virus 1 infections in atopic dermatitis (Journal ... Erratum : Reductions in claudin-1 may enhance susceptibility to herpes simplex virus 1 infections in atopic dermatitis (Journal ... Erratum : Reductions in claudin-1 may enhance susceptibility to herpes simplex virus 1 infections in atopic dermatitis (Journal ...

https://jhu.pure.elsevier.com/en/publications/erratum-reductions-in-claudin-1-may-enhance-susceptibility-to-her-4

Dive into the research topics of MicroRNA 29 targets nuclear factor-κB-repressing factor and claudin 1 to increase intestinal ... MicroRNA 29 targets nuclear factor-κB-repressing factor and claudin 1 to increase intestinal permeability. ...

https://researchexperts.utmb.edu/en/publications/microrna-29-targets-nuclear-factor-%CE%BAb-repressing-factor-and-claud/fingerprints/

EpCAM MFI were greater than 186 for most cell lines with the exception of the claudin low cell lines (Hs578T and MDA-MB-231), ... Results: Cancer cells could be recovered from all intrinsic subtypes of breast cancer with IE/FACS, however, claudin-low cell ... Nevertheless, EpCAM transcripts were detected in 100% of the cells in the claudin-low subtype, albeit at very low levels (MFI ... EpCAM based capture detects and recovers circulating tumor cells from all subtypes of breast cancer except claudin-low. ...

https://www.oncotarget.com/article/5977/text/

Claudin-2 as a mediator of leaky gut barrier during intestinal inflammation. Tissue Barriers. 2015;3(1-2):e977176. ... 2015;145(1):25-31.. *Lam YY, Ha CW, Hoffmann JM, et al. Effects of dietary fat profile on gut permeability and microbiota and ... 2016;21(1):64-69.. *Hollon J, Puppa EL, Greenwald B, Goldberg E, Guerrerio A, Fasano A. Effect of gliadin on permeability of ... 2016;311(1):G192-201.. *Swanson G, Forsyth CB, Tang Y, et al. Role of intestinal circadian genes in alcohol-induced gut ...

https://robbwolf.com/2016/11/10/could-leaky-gut-be-the-hidden-cause-of-your-health-problems-4-causes-and-4-solutions/

... ... We propose that claudin 1 functions both as a tumor suppressor as well as a tumor enhancer/facilitator in breast cancer. ... In this paper, we discuss recent advances in our understanding of the potential role of claudin 1 in breast cancer. We also ... discuss the significance of a subset of estrogen receptor negative breast cancers which express "high" levels of the claudin 1 ...

https://mspace.lib.umanitoba.ca/xmlui/handle/1993/30318

PMP22_Claudin; PMP-22/EMP/MP20/Claudin family. * NM_145814.2 → NP_665813.1 voltage-dependent calcium channel gamma-6 subunit ... PMP22_Claudin; PMP-22/EMP/MP20/Claudin family. * NM_145815.2 → NP_665814.1 voltage-dependent calcium channel gamma-6 subunit ... Conserved Domains (1) summary. cl21598. Location:54 → 137. PMP22_Claudin; PMP-22/EMP/MP20/Claudin family. ... Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).. Source sequence(s) ...

https://www.ncbi.nlm.nih.gov/gene/59285

Claudin-4 / genetics * Claudin-4 / metabolism * Gene Expression Regulation * Humans * Interferon-gamma / immunology ... Michael B Soyka 1 , Paulina Wawrzyniak, Thomas Eiwegger, David Holzmann, Angela Treis, Kerstin Wanke, Jeannette I Kast, Cezmi A ... 1 Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland. ... and decreased expression of the TJ molecules occludin and zonula occludens 1. TER was reduced in ALI cultures from patients ...

https://pubmed.ncbi.nlm.nih.gov/22840853/?dopt=Abstract

A) Claudin-1. (B) Occludin. (C)ZO-1. (D)MUC2. †p , 0.05, ††p , 0.01 vs CTR; #p , 0.05, ##p , 0.01 vs DSS; *p , 0.05, **p , 0.01 ... As described in Figure 4, both CM-MSC and CM-Ac-MSC prominently up-regulated the mRNA levels of Claudin-1, Occludin, ZO-1 and ... The CM-MSC and CM-Ac-MSC group showed about 41.2 and 58.8% higher (p , 0.01) Claudin-1 mRNA expression level than DSS group, ... CM-AcMSC enhanced the mRNA expression levels of tight junctions (Claudin, Occludin and ZO-1) and MUC2 in colon tissues, n = 6. ...

https://www.frontiersin.org/articles/10.3389/fbioe.2021.694908/full

... claudin-16), [18] a member of the claudin family of tight junction proteins that form the paracellular pathway for calcium and ... 16] In humans, mutations in the claudin-16 (previously known as paracellin-1) and claudin-19 genes cause a hereditary disease, ... 17, 18, 19] Mutations in claudin-19 are also associated with severe ocular involvement. [16] ... Unusual clinical presentation and possible rescue of a novel claudin-16 mutation. J Clin Endocrinol Metab. 2006 Aug. 91(8):3076 ...

https://www.medscape.com/answers/2038394-35964/what-is-the-association-between-hypomagnesemia-and-coronary-artery-disease-cad

Claudin, 1881).. John Ferguson (1837-1916), Professor of Chemistry, University of Glasgow: purchased at the Chasles sale 1 Aug ... 1-88]. [64] leaves.. ISTC im00551500; GW M23292; BSB-Ink M-377; H 14548*; IGI 6418. ... 1881 according to Fergusons pencil acquisition note on front pastedown "JF 1. 8. 81 Chasles Sale 1189".. University of Glasgow ...

https://www.gla.ac.uk/myglasgow/incunabula/a-zofauthorsa-j/m34/

Claudin De Sermisy (1) * Dominique Phinot (1) * Jean Mouton (1) * Johannes Lupi (1) ...

https://www.platekompaniet.no/medvirkende/brabant-ensemble/

Claudin-1 expression increased in the OB and striatum. We conclude that 2,3-pentanedione is a respiratory hazard that can also ...

http://www2a.cdc.gov/nioshtic-2/BuildQyr.asp?s1=respiratory&f1=%2A&Startyear=&Adv=0&terms=1&EndYear=&Limit=10000&sort=&D1=10&PageNo=254&RecNo=2533&View=f&

Elk-1, p53, PEA3) were decreased in tumors with high COX-2. The promoter region of COX-2 gene did not show consistent ... Claudin 1 ↑ 38 Integral membrane protein, component of tight junction strands CLDN1 (9076) ... Matrix metallopeptidase 1 ↑ 14 Breakdown of extracellular matrix, metastasis MMP1 (4312) Myosin, cardiac, beta ↑ 25 Heavy chain ... Regenerating islet-derived 1 β ↓ 16 Highly similar to REG1A protein (islet cell regeneration and diabetogenesis) REG1B (5968) ...

https://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-11-238/tables/3

Claudin II 75. 76. Bechtel C-270. Ce³ C-425. Pell 3529. 3529A. CRF V 261. CRF XVII 180. CIBN C-267. Chantilly 415. Pollard: ... Claudin IV 417. Bechtel C-258. Pell 3522. CIBN C-270. BMC VIII 285.IA 42275. ISTC ic00427700. ... Claudin IV 413. Bechtel C-280. CIBN C-274. Pr 8693. BMC VIII 285.IA 42276. ISTC ic00429100. ... Claudin III 408-409. Bechtel H-58. Pell 6058. CIBN C-282. ISTC ih00491300. ...

https://gesamtkatalogderwiegendrucke.de/docs/CHARALA.htm

9r-u). Claudin-1 expression in normal organoids also was not affected by repertaxin treatment, but it was significantly greater ... 8q2, r2, t). Claudin-1 expression did not significantly change in treated vs. control iHNOs (Supplementary Fig. 6e1, f1, g). ... However, claudin-1 expression significantly increased in iHUCOs after treatment with repertaxin (Supplementary Fig. 6e2, f2, g ... 1: Patterning of induced organoids recapitulates in vitro their primary tissues.. a Schematic representation of induced human ...

https://www.nature.com/articles/s41467-020-20351-5?error=cookies_not_supported&code=65aae6df-87ca-43c5-bf66-c7cc66530e0d

... in the developing lung and its regulation is maintained by critical transcriptional control networks managed by TTF-1. In lung ... Jimenez Rondan, Felix Ruben, "The Biology of Claudin 6 (Cldn6) in the Developing Mouse Lung" (2015). Theses and Dissertations. ... in the developing lung and its regulation is maintained by critical transcriptional control networks managed by TTF-1. In lung ...

https://scholarsarchive.byu.edu/etd/4414/

Claudin IV 201. Bechtel C-69. Pell 3403. CIBN C-157. ISTC ic00286330. ...

https://www.gesamtkatalogderwiegendrucke.de/docs/GW06243.htm

Claudin Patoulet. c.1525 - c.1570. Belgium / The Netherlands. 1. Donald Patriquin. 1938 - Canada. 1. ...

https://requiemsurvey.org/composers.php/publishers.com/w.ivan-eroed.at/de/http/templates/www.slavu.sav.sk/konferencie/uskutocnene/musik/www.ruchmuzyczny.pl/stats/stats/composers.php?start=15&sex=0

Abstract: The present invention is directed to claudin-1-specific peptide reagents, methods for detecting pre-cancer (dysplasia ... 1 of primary nucleophilic groups in excess to available electrophilic groups. The present invention is also directed to ...

https://patents.justia.com/inventor/thomas-d-wang

1 Bin Song,2 Junrong Wu,1 Yanli Zhang,1 Aijie Chen,1 Longquan Shao1,3 1Nanfang Hospital, Southern Medical University, Guangzhou ... The expression of claudin-5, occludin, ZO-1, and connexin-43 was significantly decreased. The damage caused by ZnO NPs could be ... Ruolan Wang,1 Bin Song,2 Junrong Wu,1 Yanli Zhang,1 Aijie Chen,1 Longquan Shao1,3. 1Nanfang Hospital, Southern Medical ... 1.. Ema M, Okuda H, Gamo M, Honda K. A review of reproductive and developmental toxicity of silver nanoparticles in laboratory ...

https://www.dovepress.com/potential-adverse-effects-of-nanoparticles-on-the-reproductive-system-peer-reviewed-fulltext-article-IJN

Claudin, Santiago Carrillo, pp. 78-9; Carrillo, Demain lEspagne, pp. 95-8. ... 1 Moran, Miseria y grandeza, pp. 96-7; Carrillo, Demain IEspagne, pp. 80-3; Carrillo, Memorias, pp. 394-406; Claudln, Santiago ... The implication is that, at the age of thirty, he had rediscovered the hot-headed temerity of his youth. (1) ...

https://albavolunteer.org/2014/12/the-politics-of-spanish-resistance-1944/

Omega-3-Acid Ethyl Esters Block the Protumorigenic Effects of Obesity in Mouse Models of Postmenopausal Basal-Like and Claudin ... and claudin-low (CL) subtypes ... EPA+DHA supplementation in DIO mice reduced growth of Wnt-1 and M-Wnt tumors; reduced leptin: ... 2016 Jun 22:1-8 - Women in the fourth quartile of serum 25(OH)D level had 3 times lower risk of developing breast cancer ... 2017 Oct 4:1-11 - Cancer stem cells (CSCs) ... The ability of PE to suppress CSCs can be exploited in the prevention of breast ...

https://qualitycounts.com/fpbreast.html

... gamma-catenin and claudin-7), their influence on survival in primary breast carcinoma, and their corresponding axillary lymph ... 2015 Apr;1(1):110. Citation on PubMed. *Kaurah P, Huntsman DG. Hereditary Diffuse Gastric Cancer. 2002 Nov 4 [updated 2018 Mar ... 2008 Jan;61(1):25-30. doi: 10.1136/jcp.2006.043679. Epub 2007 May 18. Citation on PubMed ... 2007 Jan;115(1):52-65. doi: 10.1111/j.1600-0463.2007.apm_524.x. Citation on PubMed ...

https://medlineplus.gov/genetics/gene/cdh1/

The growth factor TGFβ2 also causes the loss of claudin-1 leading to loss of the integrity of the skin and facilitating ... Loricrin and Claudin 1 are all proteins key to maintaining the integrity of the upper layer of the skin. When these proteins ...

https://www.ncl.ac.uk/press/articles/latest/2022/01/melanoma-test/

Claudin-10 is required for relay of left-right patterning cues from Hensens node to the lateral plate mesoderm,. Developmental ... Claudin-1 is a p63 target gene with a crucial role in epithelial development PLoS ONE , 3, 7. ... Activation of an SP binding site is crucial for the expression of Claudin 1 in rat epididymal principal cells Biology of ... In utero exposure to tributyltin alters the expression of E-cadherin and localization of claudin-1 in intercellular junctions ...

https://inrs.ca/la-recherche/professeurs/daniel-g-cyr/

Zolbetuximab is an investigational first-in-class monoclonal antibody targeting Claudin 18.2 (CLDN18.2), for the first-line treatment of patients with CLDN18.2-positive, HER2-negative, locally advanced unresectable or metastatic gastric or gastroesophageal junction (GEJ) adenocarcinoma. (pressreach.com)
CHENGDU, China , April 12, 2022 /PRNewswire/ -- Keymed Biosciences (2162.HK) announced that its new drug candidate CMG901 (the "Claudin 18.2 antibody drug conjugates") for the treatment of gastric cancer and gastroesophageal junction adenocarcinoma has been granted the Orphan-drug Designation by the Food and Drug Administration of the United States (the "FDA") recently. (prnewswire.com)
CMG901 is the first Claudin 18.2 ADC to obtained IND approval in China and in the U.S. CMG901 consists of three components: a monoclonal antibody targeting Claudin 18.2, a cleavable linker and a potent cytotoxic payload (MMAE). (prnewswire.com)
Claudin 18.2 has been identified as a highly selective molecule that is widely expressed in multiple solid tumors, including gastric cancer and pancreatic cancer, suggesting that Claudin 18.2 is an ideal target for tumor therapeutic development. (prnewswire.com)
CMG901 binds to Claudin 18.2 positive cell via its monoclonal antibody portion. (prnewswire.com)
CMG901 can stimulate cellular and soluble immune effectors that activate antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC) to destroy the Claudin 18.2 positive cells. (prnewswire.com)

Like mortar and bricks holding together a wall, AMBRA1, Loricrin and Claudin 1 are all proteins key to maintaining the integrity of the upper layer of the skin. (ncl.ac.uk)
The tetraspan membrane protein is a member of the claudin family of tight junction proteins. (lamerie.com)
Many proteins in the claudin family have high sequence identity. (lamerie.com)
ZONAB also regulates the expression and localisation of tight junction proteins JACOP and claudin-5. (bl.uk)

Recognizes endogenous levels of Claudin 1 protein. (antibodies-online.com)
We also discuss the significance of a subset of estrogen receptor negative breast cancers which express "high" levels of the claudin 1 protein. (umanitoba.ca)
The claudin megatrachea protein complex. (mpg.de)
Caused by a mutation in the CLDN1 gene on chromosome 3q28 coding for the tight junction protein claudin-1. (cdc.gov)

While claudin-low tumors showed the highest expression of immune gene signatures, they also demonstrated gene expression patterns consistent with those observed in active immunosuppression. (jci.org)

Re-expression of the miR-200s in murine and human claudin-low mammary tumor cells partially restored an epithelial cell morphology and significantly inhibited proliferation and cell invasion in vitro. (biomedcentral.com)
We summarize results from 4 different infectivity trials that used 3-D small intestinal epithelial cells ( Table 1 ). (cdc.gov)

We propose that claudin 1 functions both as a tumor suppressor as well as a tumor enhancer/facilitator in breast cancer. (umanitoba.ca)
In addition to androgen receptor (AR) regulation, one of the major steps in PCa progression, new blood vessel formation (angiogenesis) plays a major role in tumor promotion and metastatic PCa growth ( 1 , 2 ). (medsci.org)
Claudin 6 (CLDN6) is a compelling tumor antigen. (lamerie.com)
The facts that preliminary clinical experience shows high anti-tumor activity of the first drug candidate and that the competitive field still is limited, make claudin 6 an exceptionally attractive target for drug discovery and development. (lamerie.com)
We have found that murine and human mammary tumor cells with claudin-low characteristics are associated with very low levels of all five miR-200s. (biomedcentral.com)
To determine the impact of miR-200s on claudin-low mammary tumor cells, the miR-200c/141 cluster and the miR-200b/200a/429 cluster were stably re-expressed in murine (RJ423) and human (MDA-MB-231) claudin-low mammary tumor cells. (biomedcentral.com)

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. (oncotarget.com)
Translational Oncology (2022) 15 (1): 101288. (aacrjournals.org)
Hematology (2022) 27 (1): 1110. (aacrjournals.org)
Association of dietary intake of n-3 polyunsaturated fatty acids with breast cancer risk in pre- and postmenopausal Chinese women - Menopause 2022 Jul 26 - 'Higher intake of marine n-3 PUFAs and total n-3 PUFAs was associated with lower risk of breast cancer, with adjusted OR quartile 4 v.1 (95% confidence intervals) of 0.68 (0.55-0.84) and 0.56 (0.42-0.75), respectively. (qualitycounts.com)
Higher efficacy of resveratrol against advanced breast cancer organoids: A comparison with that of clinically relevant drugs - Phytother Res 2022 Jun 1 - 'The lack of reliable drugs is a therapeutic challenge of advanced breast cancers (ABCs). (qualitycounts.com)

Cldn6 is both temporally and spatially controlled in the developing lung and its regulation is maintained by critical transcriptional control networks managed by TTF-1. (byu.edu)

Scientists estimate that SOD-1 mutations play a role in a small number of cases of ALS overall in people, about one-quarter of the 10 percent or so of cases that are inherited. (news-medical.net)
In this work, the team showed that the barrier between the blood and the spinal cord weakens in all three types of genetically based ALS cases that involve SOD-1 mutations, allowing toxic substances to flood into the spinal cord and directly affect neurons. (news-medical.net)
Mutations in the gene for claudin-1 are associated with Neonatal Ichthyosis-Sclerosing Cholangitis (NISCH) Syndrome. (bvsalud.org)

Paris: Claudin, 1881). (gla.ac.uk)
1. Sotheby's (Paris) 11.XII.2015 (Sammlung Pierre Bergé Nr 5. (gesamtkatalogderwiegendrucke.de)

Cancer cells could be recovered from all intrinsic subtypes of breast cancer with IE/FACS, however, claudin-low cell lines showed very low capture rates compared to the four other groups ( p = 0.03). (oncotarget.com)
EpCAM based IE/FACS detected and captured a portion of spiked cells from each of the 10 cell lines representing all breast cancer subtypes, including basal-like but not claudin-low cancers. (oncotarget.com)
particles (norovirus GI.1, the prototype strain) after trans- fection of cultured kidney cells. (cdc.gov)
The team studied mice with a mutation in a gene for superoxide dismutase 1 (SOD-1), which in healthy people and mice plays an important role keeping cells safe from damaging molecules known as free radicals. (news-medical.net)
20 ) reported production of Norwalk virus particles (norovirus GI.1, the prototype strain of this genera from Norwalk, Ohio) after transinfection of cultured kidney cells. (cdc.gov)
Compared with normalMDCK cells, change in claudin-1 distribution between cell contacts caused by Lgl2 overexpression impairedthe barrier function of tight junction. (who.int)
Results and Dialogue Following the exclusion of useless Mitoxantrone distributor cells and/or particles (D) on ahead (FSC) versus (vs.) part scatter (SSC) plots, lymphocytes (L), monocytes (M) and granulocytes (G) had been selected by Compact disc45-APC vs. SSC plots (Fig. 1). (healthweblognews.info)
Normal dot plots Derived (FL1/FL2) vs. FL4 of cells un-stimulated (UNST) (C) or treated with PMA (1?g/ml) (D) or AAPH (10?mM) (E and F) for 30?min. (healthweblognews.info)
Treatment with 2,2-azobis(2-methylpropionamidine) dihydrochloride (AAPH) or phorbol 12-myristate 13-acetate (PMA) treatment improved the Percentage of fluorescence, however in a different way, displaying that oxidative burst induced reactive air KIAA1516 species (ROS) creation only in triggered cells, while all cells had been delicate to exogenous ROS damage (Fig. 1). (healthweblognews.info)

Journal of Oncology (2021) 2021: 1. (aacrjournals.org)
Translational psychiatry 2021 9 11 (1): 451. (cdc.gov)

On the basis of sequence diversity of the capsid gene, noroviruses can be classified into 8 genetic clusters within GI, 17 in GII, and 1 in GIV ( 11 ). (cdc.gov)

We report the discovery of a claudin-low molecular subtype of high-grade bladder cancer that shares characteristics with the homonymous subtype of breast cancer. (jci.org)

KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human Claudin 1. (antibodies-online.com)

MicroRNAs (miRNAs) are small, non-coding RNA molecules that can be found in both introns and exons [ 1 ]. (biomedcentral.com)

at least four data updates, up to three programs expected to move into randomized Phase 2 trials, and six preclinical programs moving into Phase 1 trials. (biontech.de)

Proteína integral de la membrana localizada en las UNIONES ESTRECHAS donde interviene en el control de la permeabilidad paracelular de las células polarizadas. (bvsalud.org)

Metastasis is responsible for the vast majority of breast cancer related deaths [ 1 ]. (oncotarget.com)
In this paper, we discuss recent advances in our understanding of the potential role of claudin 1 in breast cancer. (umanitoba.ca)

Association of genetic polymorphisms of claudin-1 with small vessel vascular dementia. (cdc.gov)
Peritumoral vascular invasion (0 or 1). (rdrr.io)

Total COVID-19 vaccine revenues of €270.5 million 1 for the Full Year 2020. (biontech.de)

A decreased trans-tissue resistance was found in biopsy specimens from patients with CRS with nasal polyps along with an irregular, patchy, and decreased expression of the TJ molecules occludin and zonula occludens 1. (nih.gov)
Claudin-1 expression increased in the OB and striatum. (cdc.gov)
Epithelioid versus rhabdoid glioblastomas are distinguished by monosomy 22 and immunohistochemical expression of INI-1 but not claudin 6. (neurotree.org)

ZONAB is a ZO-1 associated transcription factor that shuttles from the tight junction to the nucleus in epithelia. (bl.uk)

Type 2 rosacea sufferers were found to blush more intensely and reported higher embarrassment levels than type 1 rosacea sufferers and controls. (thailandmedical.news)

Approximately 99% of total body magnesium is intracellular or bone-deposited, with only 1% present in the extracellular space. (medscape.com)
In contrast with other ions, magnesium is treated differently in two major respects: (1) bone, the principal reservoir of magnesium, does not readily exchange magnesium with circulating magnesium in the extracellular fluid space and (2) only limited hormonal modulation of urinary magnesium excretion occurs. (medscape.com)

In vitro differentiation of small intestinal epithelium that nausea, vomiting, and watery diarrhea within 12-24 hours approaches physiologic functionality of the in vivo host of exposure and typically remain symptomatic for 1-2 may allow for the development of a pathogenesis model days ( 5 ). (cdc.gov)