A species of the PESTIVIRUS genus causing exceedingly contagious and fatal hemorrhagic disease of swine.
An acute, highly contagious disease affecting swine of all ages and caused by the CLASSICAL SWINE FEVER VIRUS. It has a sudden onset with high morbidity and mortality.
The lone species of the genus Asfivirus. It infects domestic and wild pigs, warthogs, and bushpigs. Disease is endemic in domestic swine in many African countries and Sardinia. Soft ticks of the genus Ornithodoros are also infected and act as vectors.
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
A sometimes fatal ASFIVIRUS infection of pigs, characterized by fever, cough, diarrhea, hemorrhagic lymph nodes, and edema of the gallbladder. It is transmitted between domestic swine by direct contact, ingestion of infected meat, or fomites, or mechanically by biting flies or soft ticks (genus Ornithodoros).
A genus of FLAVIVIRIDAE, also known as mucosal disease virus group, which is not arthropod-borne. Transmission is by direct and indirect contact, and by transplacental and congenital transmission. Species include BORDER DISEASE VIRUS, bovine viral diarrhea virus (DIARRHEA VIRUS, BOVINE VIRAL), and CLASSICAL SWINE FEVER VIRUS.
A species of PESTIVIRUS causing a congenital sheep disease characterized by an abnormally hairy birth-coat, tremors, and poor growth.
A family of large icosahedral DNA viruses infecting insects and poikilothermic vertebrates. Genera include IRIDOVIRUS; RANAVIRUS; Chloriridovirus; Megalocytivirus; and Lymphocystivirus.
Infections with viruses of the genus PESTIVIRUS, family FLAVIVIRIDAE.
The type species of the FLAVIVIRUS genus. Principal vector transmission to humans is by AEDES spp. mosquitoes.
Ribonucleic acid that makes up the genetic material of viruses.
Suspensions of attenuated or killed viruses administered for the prevention or treatment of infectious viral disease.
A mosquito-borne species of the PHLEBOVIRUS genus found in eastern, central, and southern Africa, producing massive hepatitis, abortion, and death in sheep, goats, cattle, and other animals. It also has caused disease in humans.
A group of viruses in the genus PESTIVIRUS, causing diarrhea, fever, oral ulcerations, hemorrhagic syndrome, and various necrotic lesions among cattle and other domestic animals. The two species (genotypes), BVDV-1 and BVDV-2 , exhibit antigenic and pathological differences. The historical designation, BVDV, consisted of both (then unrecognized) genotypes.
Layers of protein which surround the capsid in animal viruses with tubular nucleocapsids. The envelope consists of an inner layer of lipids and virus specified proteins also called membrane or matrix proteins. The outer layer consists of one or more types of morphological subunits called peplomers which project from the viral envelope; this layer always consists of glycoproteins.
A species of SWINE, in the family Suidae, comprising a number of subspecies including the domestic pig Sus scrofa domestica.
The degree of pathogenicity within a group or species of microorganisms or viruses as indicated by case fatality rates and/or the ability of the organism to invade the tissues of the host. The pathogenic capacity of an organism is determined by its VIRULENCE FACTORS.
A round-to-oval mass of lymphoid tissue embedded in the lateral wall of the PHARYNX. There is one on each side of the oropharynx in the fauces between the anterior and posterior pillars of the SOFT PALATE.
Established cell cultures that have the potential to propagate indefinitely.
Proteins encoded by a VIRAL GENOME that are produced in the organisms they infect, but not packaged into the VIRUS PARTICLES. Some of these proteins may play roles within the infected cell during VIRUS REPLICATION or act in regulation of virus replication or VIRUS ASSEMBLY.
Proteins found in any species of virus.
Viral proteins that are components of the mature assembled VIRUS PARTICLES. They may include nucleocapsid core proteins (gag proteins), enzymes packaged within the virus particle (pol proteins), and membrane components (env proteins). These do not include the proteins encoded in the VIRAL GENOME that are produced in infected cells but which are not packaged in the mature virus particle,i.e. the so called non-structural proteins (VIRAL NONSTRUCTURAL PROTEINS).
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Diseases of domestic swine and of the wild boar of the genus Sus.
Immunoglobulins produced in response to VIRAL ANTIGENS.
A CELL LINE derived from the kidney of the African green (vervet) monkey, (CERCOPITHECUS AETHIOPS) used primarily in virus replication studies and plaque assays.
The process of intracellular viral multiplication, consisting of the synthesis of PROTEINS; NUCLEIC ACIDS; and sometimes LIPIDS, and their assembly into a new infectious particle.
Visible morphologic changes in cells infected with viruses. It includes shutdown of cellular RNA and protein synthesis, cell fusion, release of lysosomal enzymes, changes in cell membrane permeability, diffuse changes in intracellular structures, presence of viral inclusion bodies, and chromosomal aberrations. It excludes malignant transformation, which is CELL TRANSFORMATION, VIRAL. Viral cytopathogenic effects provide a valuable method for identifying and classifying the infecting viruses.
Substances elaborated by viruses that have antigenic activity.
A species of NAIROVIRUS of the family BUNYAVIRIDAE. It is primarily transmitted by ticks and causes a severe, often fatal disease in humans.
An abnormal elevation of body temperature, usually as a result of a pathologic process.
Antibodies that reduce or abolish some biological activity of a soluble antigen or infectious agent, usually a virus.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
A species of CERCOPITHECUS containing three subspecies: C. tantalus, C. pygerythrus, and C. sabeus. They are found in the forests and savannah of Africa. The African green monkey (C. pygerythrus) is the natural host of SIMIAN IMMUNODEFICIENCY VIRUS and is used in AIDS research.
The presence of viruses in the blood.
The complete genetic complement contained in a DNA or RNA molecule in a virus.
An acute infectious disease primarily of the tropics, caused by a virus and transmitted to man by mosquitoes of the genera Aedes and Haemagogus. The severe form is characterized by fever, HEMOLYTIC JAUNDICE, and renal damage.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Live vaccines prepared from microorganisms which have undergone physical adaptation (e.g., by radiation or temperature conditioning) or serial passage in laboratory animal hosts or infected tissue/cell cultures, in order to produce avirulent mutant strains capable of inducing protective immunity.
The interactions between a host and a pathogen, usually resulting in disease.
An acute infection caused by the RIFT VALLEY FEVER VIRUS, an RNA arthropod-borne virus, affecting domestic animals and humans. In animals, symptoms include HEPATITIS; abortion (ABORTION, VETERINARY); and DEATH. In humans, symptoms range from those of a flu-like disease to hemorrhagic fever, ENCEPHALITIS, or BLINDNESS.
A genus of softbacked TICKS, in the family ARGASIDAE, serving as the vector of BORRELIA, causing RELAPSING FEVER, and of the AFRICAN SWINE FEVER VIRUS.
A subclass of PEPTIDE HYDROLASES that catalyze the internal cleavage of PEPTIDES or PROTEINS.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
A family of double-stranded DNA viruses containing one genus Asfivirus. It is the source of AFRICAN SWINE FEVER.
Animals considered to be wild or feral or not adapted for domestic use. It does not include wild animals in zoos for which ANIMALS, ZOO is available.
A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.
Venous vessels in the umbilical cord. They carry oxygenated, nutrient-rich blood from the mother to the FETUS via the PLACENTA. In humans, there is normally one umbilical vein.
Administration of vaccines to stimulate the host's immune response. This includes any preparation intended for active immunological prophylaxis.

Localization of pestiviral envelope proteins E(rns) and E2 at the cell surface and on isolated particles. (1/236)

The glycoproteins E(rns) of classical swine fever virus (CSFV) and E(rns) and E2 of bovine viral diarrhoea virus (BVDV) are shown to be located at the surface of infected cells by the use of indirect immunofluorescence and by cytofluorometric analysis. The positive immunostaining of the cell surface was further analysed by immunogold electron microscopy and it could be shown that only extracellular virions were labelled. Gold granules were not seen at the cellular plasma membrane. In contrast to BVDV E2, the CSFV E2 of virions sticking to the plasma membrane was not accessible to the respective monoclonal antibodies. However, CSFV particles isolated from culture supernatant were able to bind both monoclonal anti-E(rns) and anti-E2 antibodies. For CSFV and BVDV, binding of anti-E(rns) antibodies to the virions was more pronounced than that of anti-E2. This finding was unexpected since E2 is considered to be the immunodominant glycoprotein.  (+info)

Cytopathogenic and noncytopathogenic RNA replicons of classical swine fever virus. (2/236)

To determine the minimal requirements for autonomous RNA replication of classical swine fever virus (CSFV), genomes having in-frame deletions within the genes for structural and flanking nonstructural proteins were constructed, based on an infectious cDNA clone of CSFV Alfort/187. RNA was transcribed in vitro from the respective plasmids and transfected into SK-6 swine kidney cells. The replication competence of the RNA was determined by immunostaining transfected cells for CSFV NS3 protein and by analysis of cell extracts for viral RNA, as well as protein synthesis at different times after transfection. The genes encoding N(pro), C, E(rns), E1, E2, p7, and NS2 proved to be dispensable for RNA replication, but the efficiency of replication varied strongly between individual constructs. RNA replicons containing the complete NS2-NS3 gene persisted in transfected cells and continued to replicate without causing any obvious morphological or functional damage to the cells, whereas genomes lacking the NS2 gene replicated more efficiently and induced a cytopathic effect. These findings suggest that NS2, although it is not essential for pestivirus RNA replication, has a regulatory function therein. Both cytopathogenic and noncytopathogenic replicons were packaged into virus particles provided in trans by a cotransfected full-length helper virus genome.  (+info)

Classical swine fever in Sardinia: epidemiology of recent outbreaks. (3/236)

A variable region of the gene encoding the major glycoprotein (E2) of Classical Swine Fever Virus (CSFV) was sequenced from 12 Sardinian isolates which had been obtained from three geographically distinct regions of the Island. Phylogenetic analysis of these viruses and others characterized in previous studies [1, 2] indicated that (a) the Sardinian viruses were all members of the common European subgroup 2.3 and were clearly distinct from live vaccines recently used in this area; (b) they could be resolved into four distinct groups in accordance with the region or date of isolation; (c) in at least two regions wild boar/domestic swine contact was implicated in virus spread; (d) the oldest isolate (1983) and some of the recent isolates were possibly introduced from mainland Italy. In addition, this study has wider implications for the interpretation of CSFV variation. We have been able to demonstrate that small variations within this region of the virus genome (possibly less than 2.7% or five nucleotide substitutions) can be used to separate isolates into groups that precisely fit their geographical distribution. This finding is especially important for deducing the epidemiological relationships between multiple outbreaks caused by similar viruses that occur in close proximity.  (+info)

Mutations abrogating the RNase activity in glycoprotein E(rns) of the pestivirus classical swine fever virus lead to virus attenuation. (4/236)

Classical swine fever (CSF) is a severe hemorrhagic disease of swine caused by the pestivirus CSF virus (CSFV). Amino acid exchanges or deletions introduced by site-directed mutagenesis into the putative active site of the RNase residing in the glycoprotein E(rns) of CSFV abolished the enzymatic activity of this protein, as demonstrated with an RNase test suitable for detection of the enzymatic activity in crude cell extracts. Incorporation of the altered sequences into an infectious CSFV clone resulted in recovery of viable viruses upon RNA transfection, except for a variant displaying a deletion of the histidine codon at position 297 of the long open reading frame. These RNase-negative virus mutants displayed growth characteristics in tissue culture that were undistinguishable from wild-type virus and were stable for at least seven passages. In contrast to animals inoculated with an RNase-positive control virus, infection of piglets with an RNase-negative mutant containing a deletion of the histidine codon 346 of the open reading frame did not lead to CSF. Neither fever nor extended viremia could be detected. Animals infected with this mutant did not show decrease of peripheral B cells, a characteristic feature of CSF in swine. Animal experiments with four other mutants with either exchanges of codons 297 or 346 or double exchanges of both codons 297 and 346 showed that all these RNase-negative mutants were attenuated. All viruses with mutations affecting codon 346 were completely apathogenic, whereas those containing only changes of codon 297 consistently induced clinical symptoms for several days, followed by sudden recovery. Analyses of reisolated viruses gave no indication for the presence of revertants in the infected animals.  (+info)

The RNA-dependent RNA polymerases of different members of the family Flaviviridae exhibit similar properties in vitro. (5/236)

The virus-encoded RNA-dependent RNA polymerase (RdRp), which is required for replication of the positive-strand RNA genome, is a key enzyme of members of the virus family Flaviviridae. By using heterologously expressed proteins, we demonstrate that the 77 kDa NS5B protein of two pestiviruses, bovine viral diarrhoea virus and classical swine fever virus, and the 100 kDa NS5 protein of the West Nile flavivirus possess RdRp activity in vitro. As originally shown for the RdRp of hepatitis C virus, RNA synthesis catalysed by the pestivirus and flavivirus enzymes is strictly primer-dependent in vitro. Accordingly, initiation of RNA polymerization on homopolymeric RNAs and heteropolymeric templates, the latter with a blocked 3'-hydroxyl group, was found to be dependent on the presence of complementary oligonucleotide primer molecules. On unblocked heteropolymeric templates, including authentic viral RNAs, the RdRps were shown to initiate RNA synthesis via intramolecular priming at the 3'-hydroxyl group of the template and 'copy-back' transcription, thus yielding RNase-resistant hairpin molecules. Taken together, the RdRps of different members of the Flaviviridae were demonstrated to exhibit a common reactivity profile in vitro, typical of nucleic acid-polymerizing enzymes.  (+info)

Classical swine fever virus E(rns) deletion mutants: trans-complementation and potential use as nontransmissible, modified, live-attenuated marker vaccines. (6/236)

An SK6 cell line (SK6c26) which constitutively expressed the glycoprotein E(rns) of classical swine fever virus (CSFV) was used to rescue CSFV E(rns) deletion mutants based on the infectious copy of CSFV strain C. The biochemical properties of E(rns) from this cell line were indistinguishable from those of CSFV E(rns). Two E(rns) deletion mutants were constructed, virus Flc23 and virus Flc22. Virus Flc23 encoded only the utmost N- and C-terminal amino acids of E(rns) (deletion of 215 amino acids) to retain the original protease cleavage sites. Virus Flc22 is not recognized by a panel of E(rns) antibodies, due to a deletion of 66 amino acids in E(rns). The E(rns) deletion mutants Flc22 and Flc23 could be rescued in vitro only on the complementing SK6c26 cells. These rescued viruses could infect and replicate in SK6 cells but did not yield infectious virus. Virus neutralization by E(rns)-specific antibodies was similar for the wild-type virus and the recombinant viruses, indicating that E(rns) from SK6c26 cells was incorporated in the viral particles. Pigs vaccinated with Flc22 or Flc23 were protected against a challenge with a lethal dose of CSFV strain Brescia. This is the first demonstration of trans-complementation of defective pestivirus RNA with a pestiviral structural protein and opens new ways to develop nontransmissible modified live pestivirus vaccines. In addition, the absence of (the antigenic part of) E(rns) in the recombinant viral particles can be used to differentiate between infected and vaccinated animals.  (+info)

Pathogenesis of granulocytopenia and bone marrow atrophy during classical swine fever involves apoptosis and necrosis of uninfected cells. (7/236)

Granulocytopenia, a hematological hallmark of classical swine fever, is partially responsible for the suppression of innate immune defenses during classical swine fever. The present report demonstrates that this depletion was apparent as early as 3 days postinfection (p.i.). Both mature peripheral and bone marrow neutrophils were affected, whereas immature neutrophils increased absolutely in the periphery and coincidentally immature myeloid progenitors in the bone marrow. These data suggest that a pathogenic relationship exists between these compartments. The central event was not the arrest of hematopoietic cell proliferation or of the mobilization process, but instead apoptosis and possibly also necrosis were shown to play a role. This increase in apoptotic and dead cells was detected as early as 1-3 days p.i. In contrast, viral RNA in bone marrow hematopoietic cells (BMHC) was first detected 5 days p.i., and significant amounts of infected BMHC were detected only 7 days p.i., with the major target being the myeloid compartment. The increased caspase-3 activity observed supported a role for apoptotic cell death. Furthermore, the elevated caspase-9 activity indicated the involvement of the mitochondrial apoptotic pathway. Taken together, the results demonstrate that granulocytopenia and bone marrow atrophy are mediated by hematopoietic cell death and that indirect virus-host-mediated mechanisms are likely to be responsible.  (+info)

Ultrastructural glomerular changes in experimental infection with the classical swine fever virus. (8/236)

Ultrastructural studies of glomerular changes were performed on 16 pigs experimentally infected with a highly virulent strain of the classical swine fever virus. Our observations revealed the thickening of glomerular basement membranes, swelling of endothelial cells and cytoplasmic vacuolization within podocytes containing abundant viral particles. An early viral infection of podocytes was suggested as the cause of selective swelling of the foot processes of these cells with the consequent obliteration of the glomerular urinary spaces. To our knowledge this is the first report of ultrastructural evidence of classical swine fever virions infecting glomerular podocytes.  (+info)

Classical swine fever virus (CSFV) infection causes significant losses of pigs, which is characterized by hemorrhage, disseminated intravascular coagulation and leucopenia. The swine vascular endothelial cell is a primary target cell for CSFV. The aim of this study was to determine the role of CSFV infection in inducing oxidative stress (OS) in vascular endothelial cells. We demonstrated that CSFV infection induced oxidative stress in swine umbilical vein endothelial cells (SUVECs), characterized by the induction of reactive oxygen species (ROS) production and the elevations of porcine antioxidant proteins thioredoxin (Trx), peroxiredoxin-6 (PRDX-6) and heme oxygenase-1 (HO-1) expression. Furthermore, cyclooxygenase-2 (COX-2), a pro-inflammatory protein related to oxidative stress, was up-regulated while anti-inflammatory protein peroxisome proliferator-activated receptor-γ (PPAR-γ), an important mediator in vascular functional regulation, was down-regulated in the CSFV infected cells. In addition,
Graham, SP, Everett, HE, Haines, FJ, Johns, HL, Sosan, OA, Salguero, FJ, Clifford, DJ, Steinbach, F, Drew, TW and Crooke, HR (2012) Challenge of Pigs with Classical Swine Fever Viruses after C-Strain Vaccination Reveals Remarkably Rapid Protection and Insights into Early Immunity ...
Several emerging pestiviruses have been reported lately, some of which have proved to cause disease. Recently, a new ovine pestivirus (OVPV), isolated from aborted lambs, with high genetic identity to classical swine fever virus (CSFV), has proved to induce reproductive disorders in pregnant ewes. OVPV also generated strong serological and molecular cross‐reaction with CSFV. To assess the capacity of OVPV to infect swine, twelve piglets were infected either by intranasal or intramuscular route. Daily clinical evaluation and weekly samplings were performed to determine pathogenicity, viral replication and excretion and induction of immune response. Five weeks later, two pigs from each group were euthanized and tissue samples were collected to study viral replication and distribution. OVPV generated only mild clinical signs in the piglets, including wasting and polyarthritis. The virus was able to replicate, as shown by the RNA levels found in sera and swabs and persisted in tonsil for at least ...
Read Induction of immune responses in mice and pigs by oral administration of classical swine fever virus E2 protein expressed in rice calli, Archives of Virology on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
Read Pathway analysis in blood cells of pigs infected with classical swine fever virus: comparison of pigs that develop a chronic form of infection or recover, Archives of Virology on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
Classical swine fever (CSF) is a highly contagious swine disease caused by classical swine fever virus (CSFV). Previously, we demonstrated that rAdV-SFV-E2, an adenovirus-delivered, Semliki Forest virus replicon-vectored marker vaccine against CSF, is able to protect pigs against lethal CSFV challenge. From an economical point of view, it will be beneficial to reduce the minimum effective dose of the vaccine. This study was designed to test the adjuvant effects of Salmonella enteritidis-derived bacterial ghosts (BG) to enhance the protective immunity of rAdV-SFV-E2 in pigs. Groups of 5-week-old pigs (n = 4) were immunized intramuscularly twice with 105 median tissue culture infective doses (TCID50) rAdV-SFV-E2 combined with 1010 colony forming units (CFU) BG, 106 or 105 TCID50 rAdV-SFV-E2 alone or 1010 CFU BG alone at an interval of 3 weeks, and challenged with the highly virulent CSFV Shimen strain at 1 week post-booster immunization. The results show that the pigs inoculated with 105 TCID50 rAdV-SFV
Classical Swine Fever (CSF) is a serious and highly infectious viral disease of domestic pigs and wild boar (Paton and Greiser-Wilke 2003). The causative agent, Classical Swine Fever Virus (CSFV) is a small (40±60 nm) enveloped ribonucleic acid (RNA) virus with a single stranded genome with positive polarity (Horzinek et al. 1971; Moennig and Greiser-Wilke 2008). The virus is one of three pestiviruses that forms a group of economically important pathogens (Moennig et al. 1990) belonging to the Flaviviridae family. It has a close antigenic relationship with the other pestiviruses - bovine viral diarrhoea virus (BVDV) and border disease virus (BDV), as demonstrated by immunodiffusion and immunofluorescence tests, and their similar morphology and nucleic acid homology (Wengler 1991; Wengler et al. 1995). Indonesia was free from CSF until 1993. Between 1994 and 1996 thousands of pigs were reported to have died from the disease in the Indonesian regions of North Sumatera, Jakarta, Bali, Central ...
The early identification of classical swine fever epizootics is hampered by difficulties in recognising early signs of infection, due to a lack of specific clinical signs. In addition many textbook descriptions of CSF are based on observations of disease caused by historic, mainly genotype 1, strains. Our objective was to improve our knowledge of the diverse range of signs that different CSFV strains can cause by characterising the experimental infection of domestic pigs with both a recent strain of CSFV and a divergent strain. Conventional pigs were inoculated with a genotype 2.1 isolate, that caused an outbreak in the UK in 2000, and a genotype 3.3 strain that is genetically divergent from European strains. This latter strain is also antigenically distinct as it is only poorly recognised by the CSFV-specific monoclonal antibody, WH303. Transmission was monitored by use of in-contact animals. Clinical, virological and haematological parameters were observed and an extended macro- and ...
A surveillance program directed specifically at detecting Classical Swine Fever is now in progress at Iowa State University Veterinary Diagnostic Laboratory (ISU VDL). The ISU VDL is one of the 12 core laboratories in the National Animal Health Laboratory Network (NAHLN). The primary function of NAHLN labs is to participate in ongoing surveillance and response to foreign animal diseases and other events requiring an integrated laboratory effort of preparedness, controlled testing, and timely reporting. Federal funding for this program provides equipment and diagnostic reagents as well as support for technical positions and proficiency training of technicians. The ISU VDL has the in-house capability to test for Classical Swine Fever, High Pathogenic Avian Influenza and Exotic Newcastle Disease.. Diagnosticians at the ISU VDL will select suspect cases from routine submissions to the ISU VDL. The criteria listed below will be used in case selection.. ...
Classical swine fever virus (CSFV) -specific cytotoxic T lymphocytes (CTL) were derived from peripheral blood mononuclear leukocytes of immunized NIH-minipigs (MHC d/d haplotype) after in vitro restimulation with infectious CSFV. Their cytotoxic activity was determined against CSFV-infected target cells obtained from simian virus 40 (SV40) large T antigen-transfected immortalized kidney cells of a syngeneic miniature swine. Experiments with separated effector cell populations revealed that the CSFV-specific cytotoxic activity was mediated by CD4-CD6+CD8+ MHC class I-restricted T lymphocytes. Infection of target cells with various vaccinia virus/CSFV recombinants led to the identification of a major antigenic site for CSFV-specific CTL near the cleavage site between the non-structural proteins p80 (NS3) and p10 (NS4a). Using synthetic overlapping nonapeptides which covered this protein region the sequence ENALLVALF is the first sequence to be identified as an MHC class I-restricted T cell epitope
inproceedings{377967, author = {Dewulf, Jeroen and Laevens, Hans and KOENEN, F and Mintiens, Koen and de Kruif, Aart}, booktitle = {of the OIE International Conference on the Control of Infectious Animal Diseases by Vaccination}, title = {The use of conventional and marker vaccines in the control of classical swine fever epidemics}, year = {2004 ...
At his regular weekly round-up meeting with stakeholders, the Governments Chief Veterinary Officer, Jim Scudamore, emphasised the importance and reasons behind the current control measures against the outbreak of classical swine fever in East Anglia. Noting the recent reductions in the size of current infected areas, and the Commissions decision to limit the ban on exports of live pigs to Norfolk, Suffolk, and Essex, he said: Classical swine fever is a virulent disease which, once established, can be difficult to control.
Outbreaks of classical swine fever (CSF) can lead to large economic losses and have a major impact on animal welfare. A pig infected by CSF virus (CSFV) may show specific clinical symptoms (conjunctivitis, skin haemorrhages, cyanotic ears and lameness), but often the signs are aspecific (fever, dullness, diarrhoea and loss of appetite; Klinkenberg et al. 2005). Meanwhile, the infection can spread rapidly to other pigs (Laevens et al. 1998) and to other farms. At the moment the disease is first detected, a large number of farms may already be infected. To halt the epidemic, reducing the number of susceptible animals in the affected area is often required, especially in pig-dense regions. Two methods to achieve this are pre-emptive culling and emergency vaccination. Pre-emptive culling was used in the later stages of the 1997/1998 epidemic of CSF in The Netherlands, causing a large number of animals to be destroyed or prematurely slaughtered. This and subsequent experiences with foot-and-mouth ...
Zdravilo Porcilis Pesti so preučevali v okviru dveh terenskih študij varnosti, eni na pitancih in eni na svinjah, pri čemer sta bila uporabljena različna odmerka cepiva. Terenske študije potrjujejo rezultate laboratorijskih preizkusov varnosti in kažejo, da je izdelek varen za ciljne živali (pujski od 5 meseca dalje) in najobčutljivejšo kategorijo živali (breje svinje).. Glavno merilo učinkovitosti pri terenskih študijah s pujski je bilo preživetje pujskov, če so bili izpostavljeni virusu KPK pozneje v življenju. Pujski so bili testirani tudi za viremijo (prisotnost virusa v krvi). Začetek in trajanje imunosti so merili na podlagi protiteles proti antigenu (E2) virusa KPK, ki so jih tvorili pujski. Maternalno pridobljena protitelesa niso vplivala na rezultate cepljenja.. ...
Classical Swine Fever (CSF) is an endemic disease in Cuba, and an eradication strategy by zones is planned by the Official Veterinary Service. The aim of this study was to identify high-risk areas of CSF and the risk factors associated with the disease occurrence in the Pinar del Río province, one of the prioritized areas in the eradication strategy. The outbreak occurrence at district level was analyzed through a 7-year period (2009 to 2015). A high-risk cluster (RR = 5.13, 95% CI 3.49-7.56) was detected during the last 2 years of the study period in the eastern half of the province, with 38 out of 97 districts included. The rate of CSF-affected holdings had a significant increase during 2014-2015 and seems to have occurred mainly in the high-risk cluster area. Swine population density by district (heads/km2) and road length (km) by district were associated with the disease outbreak occurrence. These results provide new insights into the knowledge of the epidemiology of the disease in Cuban endemic
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Accepted name: pestivirus NS3 polyprotein peptidase. Reaction: Leu is conserved at position P1 for all four cleavage sites. Alanine is found at position P1 of the NS4A-NS4B cleavage site, whereas serine is found at position P1 of the NS3-NS4A, NS4B-NS5A and NS5A-NS5B cleavage sites. Other name(s): border disease virus NS3 endopeptidase; BDV NS3 endopeptidase; bovine viral diarrhea virus NS3 endopeptidase; BVDV NS3 endopeptidase; classical swine fever virus NS3 endopeptidase; CSFV NS3 endopeptidase; p80. Comments: The polyprotein of noncytopathogenic pestiviruses is cleaved co- and post-translationally into at least 11 proteins (Npro, C, Erns, E1, E2, p7, NS2-3, NS4A, NS4B, NS5A, and NS5B) [2]. The genomes of cytopathogenic pestivirus strains express at least one additional protein, called NS3 (p80) [2]. This enzyme, which resides in the N-terminal region of NS3 (nonstructural protein 3), is essential for generation of its own C-terminus and for processing of the downstream cleavage sites, ...
The present study investigated the transcriptomic response of porcine dendritic cells (DC) to innate stimulation in vitro and in vivo. The aim was to identify DC subset-specialization, suitable Toll-like receptor (TLR) ligands targeting plasmacytoid DC (pDC), and the DC activation profile during highly and low virulent classical swine fever virus (CSFV, strain Eystrup and Pinar del Rio, respectively) infection, chosen as model for a virus causing a severe immunopathology. After identification of porcine conventional DC (cDC) 1, cDC2, pDC and a monocyte-derived subset in lymphoid tissues, we characterized DC activation using transcriptomics, and focused on chemokines, interferons, cytokines, as well as on co-stimulatory and inhibitory molecules. We demonstrate that porcine pDC provide important signals for Th1 and interferon responses, with CpG triggering the strongest responses in pDC. DC isolated early after infection of pigs with either of the two CSFV strains showed prominent upregulation of CCL5,
2008) Classical swine fever virus vaccine stability in Lao PDR. In: Conlan, J., Blacksell, S., Morrissy, C. and Colling, A., (eds.) Management of classical swine fever and foot-and-mouth disease in Lao PDR : proceedings of an international workshop held in Vientiane, Lao PDR, 20-21 November 2006. ACIAR Proceedings No. 128. ACIAR, Canberra, Australia, pp. 80-83. Morrissy, C., Wright, L., Conlan, J., Goff, W., Colling, A., Hammond, J., Johnson, M., Blacksell, S. and Daniels, P. ...
Marie-Frédérique; Neyts, Johan; F. Koenen Source: J Gen Virol, Volume 90, Issue Pt 6, p.1335-42 (2009) Keywords: Administration, Oral Animals Antiviral Agents Classical Swine Fever Classical swine fever virus .... ...
hybridization patterns, the distinct genotypes of CSFV Brecent years. It can detect different pathogens in a could be differentiated. The results showed that the piece of chip and can differentiate the various CSFV amplified by primer CP5.6 could be classified into genotypes in the same species. In 2003, a bio-chip three genotypes, including the native, invaded, and diagnosis system was established by using classical lapinized hog cholera vaccine virus by hybridization swine fever virus (CSFV) as a model. Nucleotide with oligonucleotide probe. No cross reaction was sequences of classical swine fever virus were collected found when the bio-chip was hybridized with bovine from the GenBank, and the domestic CSFV field strains diarrhea disease virus which was closely related to the were sequenced. These sequence data were analyzed with a computer software by sequence alignment and apair of universal primers, which could amplify different News source: National Veterinary Research Insti- ...
Experimental vaccine prototypes against: Porcine Respiratory and Reproductive Syndrome Virus, porcine circovirus type 2, classical swine fever virus, African swine fever virus, porcine and avian influenza Viruses, foot-and-mouth disease virus, Haemophilus parasuis, Mycobacterium spp, Gumboro, Rift Valley fever virus and many others ...
Baroness Hayman today attended a meeting between senior MAFF officials and representatives of all industries affected by the CSF outbreak. The Minister of State had been invited to the meeting at Harleston, Norfolk, which provided a further opportunity to discuss face-to-face with those affected the practical welfare and financial problems being experienced in infected areas. Speaking after the meeting Baroness Hayman said: Classical swine fever is a highly contagious pig disease which can have a devastating impact on businesses and families, whether through the disease itself or consequential movement restrictions. I have come to East Anglia again today to listen directly to those affected by this outbreak. A variety of issues were raised which will be considered both at the control centre in Bury St Edmunds and in London. Controlling this disease remains of paramount importance to farmers and the wider industry. It is our first priority. We have been aware for some time of the potential welfare
The objective of this study was to describe oral fluid and serum antibody (IgG, IgA) responses against classical swine fever virus (CSFV) E2 and Erns proteins in pigs (n = 60) inoculated with a moderately virulent field strain (ALD, n = 30) or a modified live virus vaccine strain (LOM, n = 30). Oral fluid (n = 1391) and serum (n = 591) samples were collected from individually-housed pigs between d ...
Genetic labelling of viruses with a fluorophore allows to study their life cycle in real time, without the need for fixation or staining techniques. Within the family Flaviviridae, options for genetic labelling of non-structural proteins exist. Yet, no system to genetically label structural proteins has been put forward to date. Taking advantage of a previously described site within the structural protein E2, a fluorophore was introduced into a cytopathogenic (cpe) BVDV-1 virus (BVDVE2_fluo). This insertion was well tolerated, resulting in a 2-fold drop in titer compared to the parental virus, and remained stably integrated into the genome for more than 10 passages. The fluorophore E2 fusion protein was readily detectable in purified virus particles by Western blot and fluorescence microscopy and the particle integrity and morphology was confirmed by cryo electron microscopy. The same integration site could also be used to label the related Classical swine fever virus. Also, BVDVE2_fluo particles bound
No diagnostic sample submission is complete without including the tonsil. Because of their location in the oropharynx, the tonsils are exposed to a variety of viral and bacterial pathogens. Advances in diagnostic capabilities have made analysis of the tonsils an increasingly important tool in diagnosing a number of endemic swine diseases. United States Department of Agriculture (USDA) Animal and Plant Health Inspection Services (APHIS) now has funding to use the tonsil as part of a routine surveillance program to detect classical swine fever (CSF) and is offering incentives to encourage practitioners to submit samples for surveillance.. Tests using the tonsil have been developed by the Foreign Animal Disease Diagnostic Laboratory (FADDL) at USDAs Plum Island Animal Disease Center to aid in detection and diagnosis of CSF. USDAs Classical Swine Fever (CSF) Surveillance Procedure Manual1 includes tonsil, tonsil scrapings, and nasal swabs as appropriate samples for CSF detection if collected and ...
This video covers vaccines and diagnostic tests for avian influenza and is designed for those who will select vaccines and diagnostic tests to be used in an H5N1 avian influenza control program ...
Merck & Co., Inc., Kenilworth, NJ, USA is a global healthcare leader working to help the world be well. From developing new therapies that treat and prevent disease to helping people in need, we are committed to improving health and well-being around the world. The Merck Veterinary Manual was first published in 1955 as a service to the community. The legacy of this great resource continues as the Merck Veterinary Manual in the US and Canada and the MSD Manual outside of North America.. ...
TY - ABST. T1 - Virulence in pigs of vPader10 rescued from an infectious cDNA clone of the CSFV strain Paderborn. AU - Friis,Martin Barfred. AU - Nielsen,Jens. AU - Uttenthal,Åse. AU - Belsham,Graham. AU - Rasmussen,Thomas Bruun. PY - 2012. Y1 - 2012. N2 - The BAC clone, pBeloPader10, contains a complete cDNA of the CSFV strain Paderborn. Virus, named vPader10, was rescued from this construct by electroporation of RNA transcripts into porcine PK15 cells. To further study the characteristics of vPader10, we evaluated the virulence of this virus in vivo in pigs. An animal experiment was performed where three pigs were inoculated with vPader10 and housed in-contact with two non-inoculated pigs for 5 weeks. Following inoculation with vPader10, two out of three pigs displayed severe clinical signs of CSF from PID 14 that progressed until death of the pigs at PID 21 and PID 22, respectively. High fever (,41ºC) was observed in these pigs from PID 14 and remained at a high level until day of death. ...
Classical swine fever is currently not only a problem in certain regions of Germany but also in the Eastern Cape region. An outbreak means severe economical problems. The Eastern Cape agriculture authorities even admitted that they don`t know whether they are winning the fight against swine fever.
5 September 2000 New case of swine fever in Suffolk By FWi staff A FURTHER case of classical swine fever has been confirmed on a farm in the surveillance a
The domestic swine fever virus C strain was purified by USA, Japan, local swine fever, but the domestic swine fever epidemic is still serious. Control of classical swine fever, the industry has different views, many people think is the prob
Economics of classical swine fever - CSF - hog cholera - movement ban controls on UK pig farms in protection and surveillance zones.
It is unknown how widespread the new Linda virus is in the swine population. We are currently developing a serological test to learn more about the prevalence of the Linda virus in Austria, i.e. about the number of piglets it infects, says Lamp. The test will be important because analysis of the virus has shown that it is distantly related to the virus that causes classical swine fever. We cannot exclude the possibility that it might interfere with the official tests for swine fever. In addition, it is unclear how much of a danger the newly discovered virus poses for pig breeding. The Spanish word linda is usually translated as pretty or cute but there is nothing pretty or cute about the newly discovered Linda virus. Till Rümenapf, the Head of the Institute, notes that Because it also infects the uterus of pregnant sows, the Linda virus could disrupt the development of the piglets cerebral cortex, like infection with the Zika virus. However, we should remember that the closest ...
First report focuses on African swine fever, foot-and-mouth disease and classical swine fever as the near real-time monitoring system is developed and tested.
Overall 137 programmes have been selected for EU funding to tackle animal diseases that impact on human and animal health as well as trade. The elected programmes were granted the following allocation: Bovine Tuberculosis (about €71 million); Transmissible Spongiform Encephalopathies (about €54 million); Bovine Brucellosis (about €7.4 million), rabies (€25 million); Bluetongue (€1.5 million); Classical Swine Fever (€2.5 million); Salmonellosis (about €16.6 million); Avian influenza (€2.6 million) and African Swine Fever in Sardinia (€1.4 million ...
AUSTRIA - Some newly born piglets shiver even when they are kept warm. So-called "shaking piglets" have symptoms that resemble those of the classical swine fever, with extensive damage to the brain and the spinal cord.
Marie-Frédérique Source: Front Microbiol, Volume 6, p.1141 (2015) Abstract: Classical swine fever (CSF) is among the most detrimental diseases for the swine industry worldwide. Infected wild boar populations can .... ...
TY - CONF. T1 - New and emerging technologies: Improved laboratory and on-site detection of OIE List A viruses in animals and animal products. AU - Belak, Sandor. AU - Uttenthal, Åse. AU - Hakhverdyan, Mikhayil. AU - Allan, Gordon. AU - Sanchez-Vizcaino, Jose Manuel. AU - Istvan, Kiss. AU - Merza, Malik. AU - Brocchi, Emiliana. AU - van Reeth, Kristien. AU - King, Donald. PY - 2008. Y1 - 2008. KW - Classical swine fever. KW - Foot and Mouth Disease. KW - Virus. KW - OIE listed diseases. M3 - Poster. T2 - 2nd Annual Meeting EPIZONE. Y2 - 4 June 2008 through 6 June 2008. ER - ...
Alamian S, Amiry K, Bahreinipour A, Etemadi A, Tebianian M, Mehrabadi MHF and Dadar M (2021) Brucella species circulating in rural and periurban dairy cattle farms: a comparative study in an endemic area. Tropical Animal Health and Production 53:200. doi:10.1007/s11250-021-02645-y.. Amarir F, Rhalem A, Sadak A, Raes M, Oukessou M, Saadi A, Bouslikhane M, Gauci CG, Lightowlers MW, Kirschvink N and Marcotty T (2021) Control of cystic echinococcosis in the Middle Atlas, Morocco: Field evaluation of the EG95 vaccine in sheep and cesticide treatment in dogs. PLoS Neglected Tropical Diseases 15:e0009253. doi:10.1371/journal.pntd.0009253.. Bazarragchaa E, Isoda N, Kim T, Tetsuo M, Ito S, Matsuno K and Sakoda Y (2021) Efficacy of oral vaccine against classical swine fever in wild boar and estimation of the dsease dynamics in the quantitative approach. Viruses 13. doi:10.3390/v13020319.. Bertran K, Kassa A, Criado MF, Nuñez IA, Lee DH, Killmaster L, Sá E Silva M, Ross TM, Mebatsion T, Pritchard N and ...
Dr. Dilip Kumar Sarma received his B.V.Sc &A.H. Degree from Assam Agricultural University in 1978 securing first class first position. He did his M.V.Sc and Ph.D degrees in Veterinary Bacteriology and Virology from Punjab Agricultural University, Ludhiana, India in 1981 and 1987 respectively. He had one year post doctoral research training at the AFRC Institute for Animal Health, Pirbright Laboratory, Surrey, U.K. under Commonwealth Govt. Scholarship. He has worked as Lecturer, Asstt. Professor, Virologist and as a Professor in the Department of Microbiology, Assam Agricultural University, Khanapara, Guwahati, since 2004. He has received the National Fellow Award of the Indian Council of Agricultural Research, New Delhi, India to work in a project on Classical swine fever and he has been working in the project since 2005. He has guided four Ph.D students, published two textbooks and 165 research papers in the National and International Journals and several popular scientific articles. He has ...
At least 210 pigs and piglets have died due to outbreak of classical swine flu in Mizoram-Myanmar border Champhai town and Biate village in Champhai
Hog Cholera (Classical Swine Fever). Sandra Axiak and Carolin Winter. Definition of hog cholera:. highly contagious viral disease of swine can cause acute, chronic, or congenital disease considered a foreign animal disease. Foreign animal disease (FAD):. Definition: Slideshow 113381 by flora
Virions from hog cholera virus (HCV), a member of the genus Pestivirus, were analyzed by using specific antibodies. The nucleocapsid protein was found to be a 14-kDa molecule (HCV p14). An equivalent protein could also be demonstrated for virions from another pestivirus, bovine viral diarrhea virus. The HCV envelope is composed of three glycoproteins, HCV gp44/48, gp33, and gp55. All three exist in the form of disulfide-linked dimers in virus-infected cells and in virions; HCV gp44/48 and gp55 each form homodimers, whereas gp55 is also found dimerized with gp33. Such complex covalent interactions between structural glycoproteins have not been described so far for any RNA virus. ...
Background The genus pestivirus within the family Flaviviridaeincludes bovine viral diarrhoea virus (BVDV) types 1 and 2, border disease virus (BDV) and classical swine fever virus. The two...
Wang, L., S. Mi, R. Madera, L. Ganges, M.V. Borca, J. Ren; C. Cunningham, A.G. Cino-Ozuna, H. Li, C. Tu, W. Gong; and J. Shi. 2020. A neutralizing monoclonal antibody-based competitive ELISA for classical swine fever C-strain post-vaccination monitoring. BMC Veterinary Research. Open Access. https://link.springer.com/article/10.1186/s12917-020-2237-6. Borca, M.V., V. ODonnell, L.G. Holinka, G.R. Risatti, E. Ramirez-Medina, E.A. Vuono, J. Shi, S. Pruitt, A. Rai, E. Silva, L. Velazquez Salinas, and D.P. Gladue. 2020. Deletion of CD2-like gene from the genome of African swine fever virus strain Georgia does not attenuate virulence in swine. Scientific Reports. 10:494.. Evans, T.S., Z. Shi, M. Boots, W. Liu, K. Olival, X. Xiao, S. Vandewoude, H. Brown, J. Chen, D. Civitello, L. Escobar, Y. Grohn, H. Li, K. Lips, Q. Liu, J. Lu, B. Martinez-Lopez, J. Shi, X. Shi, B. Xu, L. Yuan, G. Zhu, and W. Getz. 2020. Synergistic China-US Ecological Research is Essential for Global EID Preparedness. EcoHealth. ...
occurs in South America, Asia (including Indonesia) and certain European countries. Information on current country status can be obtained from the OIE World Animal Health Information Database. The last time CSF occurred in Australia was in 1962. Outbreaks have recently been reported in Bulgaria (in wild species), Israel and Lithuania.. Classical swine fever virus is a highly contagious Pestivirus which only infects swine, and is antigenically related to border disease virus and bovine viral diarrhoea virus. Pig to pig transmission is most common but CSF can also be spread by aerosol, swill feeding and mechanically by insects and fomites. Swill feeding of peri-urban pigs is a likely method of re-introduction of this virus to Australia and hence CSF may first be encountered by a veterinary practitioner servicing these areas. Strains vary greatly in their virulence. The last outbreak in Australia was caused by a mild strain that was detected only by a reported increase in fevered carcasses at ...
In 2016, two small-scale fattening pig farms (about 200 or 300 American Landrace pigs in total), locating in Guangdong province (southern China) and Jilin province (northern China) separated by more than 3, 000 km in distance (Fig. 1), suffered from severe respiratory disease (SRD). Pigs (2-3 months old) on both farms have received immunizations against PCV2, pseudorabies virus (PRV), classical swine fever virus (CSFV) and type 2 porcine reproductive and respiratory syndrome virus (PRRSV). However, the morbidity rate of pigs on the two farms was approximately 60%, the mortality in affected pigs was about 80%. From autopsy results of 18 individual dead pigs (n = 8 for farm A, n = 10 for farm B) (Additional file 1: Table S1), the similar macroscopic lesions were concentrated in the lungs and lymph nodes, which was characterized by PRRSV- or PCV2-like lesions including pulmonary interstitial widening, congestion and lymphadenopathy bleeding. These 18 pig lung samples were defined as the samples ...
APHIS recognizes the prevalence of CSF in Guatemala and responded immediately to their request for assistance to help control their latest outbreak, said Dr. John R. Clifford, USDAs Chief Veterinary Officer. We sent a team of subject matter experts to assess the situation and concluded that the use of much-needed vaccine would help in containing the spread of the disease.. On March 19, APHIS donated the vaccines based on a request for assistance from the Guatemalan Chief Veterinary Officer, Dr. Humberto Maldonado, to help Guatemala control the spread of CSF there.. This assistance will help control and limit spread of CSF in Guatemala and neighboring countries. Among these countries are Mexico, currently working to control and eradicate the disease, and the United States, which has been free of CSF for over 30 years. Thus, this assistance extends beyond Guatemala and contributes to safeguarding animal health throughout Central and North America.. With trade opportunities increasing each ...
swine fever virus N(pro) protein: has autoproteolytic activity; inhibits double-stranded RNA-mediated apoptosis and IFN-alpha/beta induction; GenBank AF144472
Exotic animal diseases (EADs) are characterized by their capacity to spread global distances, causing impacts on animal health and welfare with significant economic consequences. We offer a critique of current import risk analysis approaches employed in the EAD field, focusing on their capacity to assess complex systems at a policy level. To address the shortcomings identified, we propose a novel method providing a systematic analysis of the likelihood of a disease incursion, developed by reference to the multibarrier system employed for the United Kingdom. We apply the network model to a policy-level risk assessment of classical swine fever (CSF), a notifiable animal disease caused by the CSF virus. In doing so, we document and discuss a sequence of analyses that describe system vulnerabilities and reveal the critical control points (CCPs) for intervention, reducing the likelihood of U.K. pig herds being exposed to the CSF virus. ...
How BVDV affects fetal development depends on the timing of maternal infection during pregnancy. The eyes and central nervous system are targets of the virus, and characteristic deformations of the brain and skull are observed. These deformities include hydranencephaly, hydrocephalus, and microencephaly [6].. BVDV is not transmissible to people but can infect a number of ruminants. Other species in the pestivirus family - siblings to bovine viral diarrhea - include border disease of sheep and classical swine fever in pigs. All of these pestiviruses can cause birth deformities.. Another fascinating aspect of pestiviruses is that they can affect host immunity during infection. BVDV is capable of becoming a persistent infection that is never fully cleared from the body. Persistent infection can happen in a number of ways. BVDV can manipulate the mechanisms that identify pathogens in the body. The virus is therefore camouflaged as self and avoids targeting by the immune system [7]. Calves may be ...
Imports of pork rinds, a snack food made from deep-fried pork skins, are so well cooked that the risk of transmitting hog diseases, such as foot-and-mouth disease, swine vesicular disease, African swine fever and classical swine fever, is non-existent, said the U.S. Department of Agriculture's Animal and Plant Health Inspection Service.
The European Commission said that given the serious impact that animal disease outbreaks can have on human health, society, the economy and trade, the allocation of EU co-financing will continue to assist national authorities to put in place precautionary measures, disease surveillance and eradication programmes, at national and European level.. Overall 142 programmes have been selected for EU funding: Bovine Tuberculosis (about €56 million); Transmissible Spongiform Encephalopathies (about €42 million); Rabies (€27.5 million); Salmonellosis (about €17.5 million); Bovine Brucellosis (about €10 million); Classical Swine Fever (€3 million); Avian Influenza (€2.5 million); Bluetongue (€1.5 million); African Swine Fever and Swine Vesicular Disease in Italy (about €850.000).. EU co-financing has resulted in a continuous decrease in the number of cases of diseases, such as Salmonellosis (the second most frequently reported zoonotic disease in humans) and Transmissible Spongiform ...
Bovine Viral Diarrhoea (BVD) is a highly contagious viral disease of cattle. It is one of the most costly cattle diseases in the world, causing a variety of illnesses that can result in death. This animation describes the problem that farmers face in the battle against BVD, and what preventative measures can be taken to combat it.. Bovine viral diarrhoea (BVD) is closely related to the viruses that cause classical swine fever in pigs and border disease in sheep. The disease is widespread around the world and has a major economic impact in the cattle industry. Estimated losses in a beef herd can be as much as £45,000 over a ten year period while these losses are even higher in Dairy herds!. Infection in pregnant animals can result in abortion, the birth of stunted or deformed calves and calves born with persistent infection (PI). Infection during the first third of pregnancy can compromise the development of the foetal immune system and the calf is unable to eliminate the virus. PIs often ...
Romania will be resuming on-farm vaccinations against classical swine fever (CSF) soon, the website of the US Department of Agriculture says.
At the IVMR, a rich past and an intense present complement each other. József Csontos (1889-1962), founding director of the then-called Animal Health Research Institute, together with Aladár Aujeszky developed the so-called carbolic glycerinated vaccine against rabies containing fixed virus. After World War II, he played a pivotal role in the eradication of infectious animal diseases, above all classical swine fever and porcine erysipelas, and also took part in organizing the healthcare of large stocks in intensive animal farming. Among past researchers of the institute, one of worldwide fame was Domokos Derzsy (1914-1975), whose scientific topics of interest spanned almost the entire spectrum of infectious animal diseases. He diagnosed and described several poultry diseases unknown in Hungary before, one of these was that caused by goose Parvovirus, which was named Derzsys disease in honor of his internationally significant research on this pathogen. Adorján Bartha (1923-1996) also worked ...
At the IVMR, a rich past and an intense present complement each other. József Csontos (1889-1962), founding director of the then-called Animal Health Research Institute, together with Aladár Aujeszky developed the so-called carbolic glycerinated vaccine against rabies containing fixed virus. After World War II, he played a pivotal role in the eradication of infectious animal diseases, above all classical swine fever and porcine erysipelas, and also took part in organizing the healthcare of large stocks in intensive animal farming. Among past researchers of the institute, one of worldwide fame was Domokos Derzsy (1914-1975), whose scientific topics of interest spanned almost the entire spectrum of infectious animal diseases. He diagnosed and described several poultry diseases unknown in Hungary before, one of these was that caused by goose Parvovirus, which was named Derzsys disease in honor of his internationally significant research on this pathogen. Adorján Bartha (1923-1996) also worked ...
Outbreaks of notifiable infectious animal diseases, such as foot-and-mouth disease, classical swine fever and avian influenza, have major societal and economic consequences. Fortunately, such animal diseases occur infrequently in the Netherlands. Wageningen Bioveterinary Research (WBVR) contributes to this status by designing risk-based surveillance systems.
26 September 2000 Unigate blames losses on swine fever UNIGATE has blamed the outbreak of swine fever for preventing its pork processing plant in North Yor
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Countries across Asia are struggling to contain an outbreak of swine fever, which is threatening the livelihoods of millions of families that rely on pig farming. The highly contagious and incurable virus is deadly to pigs but not dangerous to humans. The disease originally spread from Africa
Another case of swine fever was detected in Manta in Cahul district. The virus was confirmed by laboratory analysis after a man announced to the National Agency for Food Safety in the district that he had found his pig dead.Immediately, the emergency comm
Global price cycle, Swine Fever outbreak in S Korea, China bans Dutch food imports, USDA forecasts, EU vets vote for new Spanish and German CSF measures, UK farmers suffer second FMD scare.....
Sigma-Aldrich offers abstracts and full-text articles by [Jiangnan Li, Yajuan Dai, Shuai Liu, Huancheng Guo, Tiedong Wang, Hongsheng Ouyang, Changchun Tu].
In der medizinischen Versorgung bekommt die Ernährung einen immer größeren Stellenwert. Zum einen sind heute Nahrungsmittelunverträglichkeiten häufiger anzutreffen, andererseits wird eine Ernährungsth
"U18666A inhibits classical swine fever virus replication through interference with intracellular cholesterol trafficking". ... Finally, SNX8 also plays an antiviral role against RNA viruses such as SeV (Sendai virus) through VISA-mediated activation of ... In addition, SNX8 plays an antiviral role against DNA viruses such as HSV-1 through the MITA-mediated activation of the IFNβ ... SNX8 is a key component in the induction of downstream effector antiviral gene transcription in response to RNA viruses, as it ...
"Ribosomal binding to the internal ribosomal entry site of classical swine fever virus". RNA. 6 (12): 1791-1807. doi:10.1017/ ...
The classical swine fever virus UTR described appears to be longer at the 5' end than other pestivirus UTRs. This family ... "Ribosomal binding to the internal ribosomal entry site of classical swine fever virus". RNA. 6 (12): 1791-1807. doi:10.1017/ ...
... interacting protein involved in classical swine fever virus growth". Journal of Virology. 87 (4): 2072-80. doi:10.1128/JVI. ... study found that a Sus scrofa PRR29-like protein interacts with the N-terminal protease of classical swine fever virus (CSFV). ...
Klassisches Schweinepest-Virus - en. Classical swine fever virus (CSFV) oder Hog cholera virus ... Usutu-Virus - en. Usutu virus (USUV), Zika-Virus - en. Zika virus (ZIKV), sowie Gelbfieber-Virus - en. Yellow fever virus (YFV) ... Genus ‚Negevirus', mit Species ‚Blackford virus', ‚Bofa virus', ‚Buckhurst virus', ‚Marsac virus', sowie ‚Muthill virus'[53] ... Sorghum mosaic virus (SrMV), Lily-Mottle-Virus - en. Lily mottle virus (LMoV), sowie Sellerie-Virus Y - en. Apium virus Y (ApVY ...
... bovine viral diarrhea virus NS3 endopeptidase, BVDV NS3 endopeptidase, classical swine fever virus NS3 endopeptidase, CSFV NS3 ... Xu J, Mendez E, Caron PR, Lin C, Murcko MA, Collett MS, Rice CM (July 1997). "Bovine viral diarrhea virus NS3 serine proteinase ... Tautz N, Kaiser A, Thiel HJ (August 2000). "NS3 serine protease of bovine viral diarrhea virus: characterization of active site ... Pestivirus NS3 polyprotein peptidase (EC 3.4.21.113, border disease virus NS3 endopeptidase, BDV NS3 endopeptidase, ...
Nipah virus infection, Rift Valley fever, capripox, lumpy skin disease, glanders, and classical swine fever. Animal Care - The ... Diseases of primary concern are: classical swine fever, African swine fever, Newcastle disease, and notifiable avian influenza ... classical swine fever, and Nipah and Hendra virus infections. The NCFAD has received designations by the World Organization for ... Hendra virus, Ebola virus and Rift Valley fever virus. The Section maintains a state of readiness for emergencies or outbreak ...
... causes Bovine viral diarrhea and Mucosal disease Pestivirus C or Classical swine fever virus (CSFV), causes Classical swine ... Pestivirus is a genus of viruses, in the family Flaviviridae. Viruses in the genus Pestivirus infect mammals, including members ... Replication follows the positive stranded RNA virus replication model. Positive-stranded RNA virus transcription is the method ... The 7th ESVV Pestivirus Symposium-Uppsala, Sweden 2008 Animal viruses Virus Pathogen Database and Analysis Resource (ViPR): ...
"Ribosomal binding to the internal ribosomal entry site of classical swine fever virus". RNA. 6 (12): 1791-1807. doi:10.1017/ ... nontranslated region of hepatitis A virus RNA: comparison with the IRES of encephalomyocarditis virus". Journal of Virology. 68 ... For influenza A virus, its primary method of action as an antiviral is to prevent the uncoating of viral genome which inhibits ... This results in a longer period required until maximum shedding of the virus is reached. This also results in cell death only ...
... including classical swine fever virus, and Hepacivirus genus, including Hepatitis C virus. The SVV IRES RNA shares similarities ... Positive stranded RNA virus transcription is the method of transcription. The virus exits the host cell by lysis, and ... Virotherapy Oncolytic virus "Viral Zone". ExPASy. Retrieved 15 June 2015. CS1 maint: discouraged parameter (link) ICTV. "Virus ... "Safety Study of Seneca Valley Virus in Patients With Solid Tumors With Neuroendocrine Features". "Seneca Valley Virus-001 After ...
... feline immunodeficiency virus (FIV), tuberculosis, Texas cattle fever, classical swine fever (hog cholera), heartworm, and ... In the 1940s, Jonas Salk used rhesus monkey studies to isolate the most virulent forms of the polio virus, which led to his ... Moreover, persistent virus infections (for example, herpesviruses) are activated in humans, but not in SPF mice, with septic ... Several of the bacterial viruses (bacteriophage) that infect E. coli also have been very useful for the study of gene structure ...
Feline immunodeficiency virus (FIV), tuberculosis, Texas cattle fever, Classical swine fever (hog cholera), Heartworm and other ... Virus-typing of polio by Salk [6] Salk polio virus [7] History of polio vaccine ""the work on [polio] prevention was long ... In the 1940s, Jonas Salk used rhesus monkey cross-contamination studies to isolate the three forms of the polio virus that ... Albert Sabin made a superior "live" vaccine by passing the polio virus through animal hosts, including monkeys. The vaccine was ...
... virus QI09AD03 Porcine reproductive and respiratory syndrome (PRRS) virus QI09AD04 Classical swine fever virus QI09AE01 ... porcine influenza virus QI09AA05 Porcine reproductive and respiratory syndrome (PRRS) virus QI09AA06 Classical swine fever ... QI09AA01 Aujeszky's disease virus QI09AA02 Porcine parvovirus QI09AA03 Porcine influenza virus QI09AA04 Aujeszky's disease ... erysipelothrix QI09AL04 Porcine influenza virus + erysipelothrix QI09AL05 Porcine transmissible gastro-enteritis virus + ...
Other members of this genus cause Border disease (sheep) and classical swine fever (pigs) which cause significant financial ... Ncp viruses can induce persistent infection in cells and have an intact NS2/3 protein. In cp viruses the NS2/3 protein is ... Animal viruses Fray, M.D; Paton, D.J; Alenius, S.; et al. (2000). "The effects of bovine viral diarrhoea virus on cattle ... The virus therefore entered the fetal cells and, during immune system development, was accepted as self. In PIs the virus ...
African swine fever virus (ASFV) is a large double-stranded DNA virus which replicates in the cytoplasm of infected cells and ... They cause Classical swine fever (CSF) and Bovine viral diarrhea(BVD). Mucosal disease is a distinct, chronic persistent ... West Nile virus, Israel turkey meningoencephalomyelitis virus, Sitiawan virus, Wesselsbron virus, yellow fever virus and the ... Flaviviruses include the West Nile virus, dengue virus, Tick-borne Encephalitis Virus, Yellow Fever Virus, and several other ...
... then returned to Minnesota and studied classical swine fever (also known as hog cholera). Bachrach found that the disease could ... Bachrach was able to purify the virus responsible for foot-and-mouth disease. In 1950, having spent a year in Europe, Bachrach ... The other 90% of the specimen was "gunk" from the cells involved in the process of growing the virus, but no previous ... "Howard Bachrach, pioneer in fight against polio and other viruses". Star Tribune. July 25, 2008. Retrieved June 2, 2016.. ...
International Committee on Taxonomy of Viruses. Retrieved 21 August 2019. ...Classical swine fever virus becomes Pestivirus C ... Classical Swine Fever, Iowa State University Species Profile - Classical Swine Fever, National Invasive Species Information ... Classical swine fever (CSF) or hog cholera (also sometimes called pig plague based on the German word Schweinepest) is a highly ... CSF page of Pig Disease Information Centre (UK) Current status of Classical Swine Fever worldwide at OIE. WAHID Interface - OIE ...
... classical swine fever virus MeSH B04.909.777.411 - hepatitis delta virus MeSH B04.909.777.415 - hepatitis e virus MeSH B04.909. ... diarrhea virus 2, bovine viral MeSH B04.820.250.700.400 - classical swine fever virus MeSH B04.820.410.050 - allolevivirus MeSH ... yellow fever virus MeSH B04.820.250.400 - gb virus a MeSH B04.820.250.405 - gb virus b MeSH B04.820.250.410 - GB virus C MeSH ... rift valley fever virus MeSH B04.820.087.710.750 - sandfly fever naples virus MeSH B04.820.087.710.900 - uukuniemi virus MeSH ...
"African Swine Fever Summary sheets" (PDF). "Classical Swine Fever" (PDF). August 2008. "Classical Swine Fever (hog cholera) ... "With high virulent forms of the virus, ASF is characterized by high fever, loss of appetite, hemorrhages in the skin and ... Classical swine fever (hog cholera) Classical swine fever (CSF), also known as hog cholera, is a highly contagious and ... Lesions of classical swine fever are clinico-pathologically indistinguishable from African swine fever; it is essential to send ...
... such as classical swine fever, avian influenza, Actinobacillus pleuropneumonia and Salmonella infections in pigs. Prior to the ... Eggs were used for virus propagation in the development of a yellow fever vaccine in 1935 and a influenza vaccine in 1945. In ... "Glycoprotein E1 of hog cholera virus expressed in insect cells protects swine from hog cholera". Journal of Virology. 67 (9): ... therefore increasing vaccine potency against Bovine Viral Diarrhea Virus (BVDV). Medicine portal Viruses portal Biologics ...
The clinical symptoms of ASFV infection are very similar to classical swine fever, and the two diseases normally have to be ... Viruses portal Veterinary virology Dixon; et al. (2008). "African Swine Fever Virus". Animal Viruses: Molecular Biology. ... African swine fever virus (ASFV) is a large, double-stranded DNA virus in the Asfarviridae family. It is the causative agent of ... Dixon, L.K.; Chapman, D.A.G.; Netherton, C.L.; Upton, C. (2013). "African swine fever virus replication and genomics". Virus ...
... such as classical swine fever,[123] avian influenza,[124] Actinobacillus pleuropneumonia[125] and Salmonella infections in pigs ... Soon scientist cultivated other viruses in eggs. Eggs were used for virus propagation in the development of a yellow fever ... "Glycoprotein E1 of hog cholera virus expressed in insect cells protects swine from hog cholera". Journal of Virology. 67 (9): ... "Influenza and Other Respiratory Viruses. 10 (1): 2-8. doi:10.1111/irv.12351. ISSN 1750-2640. PMC 4687503. PMID 26439108.. ...
... formerly Classical swine fever virus) Foot-and-mouth disease virus Goatpox virus Lumpy skin disease virus Avian avulavirus 1 ( ... Rift Valley fever phlebovirus Venezuelan equine encephalitis virus African horse sickness virus African swine fever virus Avian ... formerly peste des petits ruminants virus) Rinderpest morbillivirus Sheeppox virus Swine vesicular disease virus Andes ... Eastern subtype Flavivirus Siberian subtype Flavivirus Kyasanur Forest disease virus Omsk hemorrhagic fever virus Variola virus ...
... modelling classical swine fever incursions in wild pigs in Australia". Veterinary Research. 43 (1): 3. doi:10.1186/1297-9716-43 ... Contemporary diseases of zoonotic origin include SARS, Lyme disease and West Nile virus. Disease emergence and resurgence in ... red grouse and louping ill virus". Journal of Applied Ecology. 47 (4): 926-930. doi:10.1111/j.1365-2664.2010.01834.x. ISSN 1365 ...
... classical swine fever virus, previously hog cholera virus)). Viruses in this genus infect nonhuman mammals. Unclassified Other ... type species Yellow fever virus, others include West Nile virus, Dengue virus, and Zika virus). Genus Hepacivirus (type species ... GB virus B)) Genus Pegivirus (includes Pegivirus A (GB virus A), Pegivirus C (GB virus C), and Pegivirus B (GB virus D)) Genus ... Guaico Culex virus, Jingmen tick virus and Mogiana tick virus. These viruses have a segmented genome of 4 or 5 pieces. Two of ...
African horse sickness virus African swine fever virus Avian influenza virus (highly pathogenic) Classical swine fever virus ... viruses: African VHF viruses: Crimean-Congo hemorrhagic fever virus Ebola virus* Lassa fever virus Lujo virus Marburg virus* ... Asian VHF viruses: Kyasanur Forest disease virus Omsk hemorrhagic fever virus South American VHF viruses: Chapare virus ... Hendra virus Nipah virus Rift Valley fever virus Venezuelan equine encephalitis virus (excluding enzootic subtypes ID and IE) ...
... classical swine fever,[109] avian influenza,[110] Actinobacillus pleuropneumonia[111] and Salmonella infections in pigs.[112] ... The DIVA strategy has been applied in various countries and successfully eradicated pseudorabies virus. Swine populations were ... "Glycoprotein E1 of hog cholera virus expressed in insect cells protects swine from hog cholera". Journal of Virology. 67 (9): ... Examples include the subunit vaccine against Hepatitis B virus that is composed of only the surface proteins of the virus ( ...
... african swine fever MeSH C22.905.170 - classical swine fever MeSH C22.905.260 - edema disease of swine MeSH C22.905.323 - ... marburg virus disease MeSH C22.735.500.850 - simian acquired immunodeficiency syndrome MeSH C22.735.750 - monkeypox MeSH ... swine erysipelas MeSH C22.905.850 - swine vesicular disease MeSH C22.905.927 - vesicular exanthema of swine The list continues ... of swine MeSH C22.905.626 - pneumonia of swine, mycoplasmal MeSH C22.905.700 - porcine reproductive and respiratory syndrome ...
Some, like classical swine fever and scrapie are specific to one type of stock, while others, like foot-and-mouth disease ... This virus is easily transmissible to domestic poultry, and to humans living in close proximity with them. Other infectious ... "Classical swine fever" (PDF). The Center for Food Security and Public Health. Retrieved 20 May 2017. "Scrapie Fact Sheet". ... An outbreak of Nipah virus in Malaysia in 1999 was traced back to pigs becoming ill after contact with fruit-eating flying ...
... disease is considered to be the most economically important viral disease of swine in areas where classical swine fever (hog ... The virus is shed in the saliva and nasal secretions of swine infected by the respiratory route. Aerosolization of the virus ... Swine (both domestic and feral) are usual reservoirs for this virus, though it does affect other species. Aujeszky's disease ... Diagnosis is made mainly by virus isolation in tissue cultures, or through ELISA or PCR tests. Vaccines are available for swine ...
Indian swine flu (2015). *South Korean MERS (2015). *Angolan yellow fever (2016) ... "Origin of measles virus: divergence from rinderpest virus between the 11th and 12th centuries.", Virol. J., 7 (52). ... Post-classical. *First plague pandemic (541-767). *Plague of Justinian (541-542) ... He described the plague as "great" and of long duration, and mentioned fever, diarrhea, and pharyngitis as well as a skin ...
This ancestor virus diverged about 1913-1915 into two clades (or biological groups), which gave rise to the classical swine and ... yellow fever, diphtheria, and cholera all occurred near the same time. These outbreaks probably lessened the significance of ... One hypothesis is that the virus strain originated at Fort Riley, Kansas, in viruses in poultry and swine which the fort bred ... Both the H2N2 and H3N2 pandemic strains contained avian flu virus RNA segments. "While the pandemic human influenza viruses of ...
... and swine influenza viruses, allowing for mixtures of genes (reassortment) to create a new virus, which can cause an antigenic ... Post-classical. *First plague pandemic (541-767). *Plague of Justinian (541-542) ... Angolan yellow fever (2016). *Yemeni cholera (2016-present). *Gorakhpur Japanese encephalitis (2017) ... DNA virus. HBV (B). RNA virus. CBV. HAV (A). HCV (C). HDV (D). HEV (E). HGV (G). ...
Indian swine flu (2015). *South Korean MERS (2015). *Angolan yellow fever (2016) ... Post-classical. *First plague pandemic (541-767). *Plague of Justinian (541-542) ... Kerala Nipah virus (2018). *Équateur province Ebola (2018). *Kivu Ebola (2018-2020) ...
If due to a virus, the condition usually resolves within one week.[18] Some viral infections also involve fever, fatigue, ... Zimmerman, Jeffrey; Karriker, Locke; Ramirez, Alejandro; Kent Schwartz; Gregory Stevenson (15 May 2012). Diseases of Swine ( ... Classical diabetic ketoacidosis (DKA) presents with abdominal pain, nausea, and vomiting, but without diarrhea.[1] One study ... DNA virus. HBV (B). RNA virus. CBV. HAV (A). HCV (C). HDV (D). HEV (E). HGV (G). ...
Indian swine flu (2015). *MERS in South Korea (2015). *Angolan yellow fever (2016) ... Post-classical. *First plague pandemic (541-767). *Plague of Justinian (541-542) ... Kerala Nipah virus (2018). *Équateur province Ebola (2018). *Kivu Ebola (2018-present) ...
Marion Dorsett, discovered in 1903 that swine fever (hog cholera) was caused by a virus; in 1935 he helped develop the crystal ... Private schools include Agathos Classical School, Zion Christian Academy and Columbia Academy. The city is home to the main ... that hog cholera is caused by an ultramicroscopic virus, and hogs recovered from the disease are immune for life." Sterling, ...
... especially Japanese encephalitis virus), Machupo virus, Marburg virus, Variola virus, and yellow fever virus. Fungal agents ... African swine fever for pigs, and psittacosis to kill the chicken. These agents were prepared to spray them down from tanks ... It is important to note that most classical and modern biological weapons' pathogens can be obtained from a plant or an animal ... Many viral agents have been studied and/or weaponized, including some of the Bunyaviridae (especially Rift Valley fever virus ...
"Ian Lipkin The Virus Hunter" (PDF). Discover. April 2012. Zimmer, Carl (November 22, 2010). "A Man From Whom Viruses Can't Hide ... Within this consortium, his research focused on pathogen discovery, using unexplained hemorrhagic fever, febrile illness, ... such as swine. Lipkin addressed a health forum in Guangzhou in January 2004 where China Daily reported him as saying: "SARS ... "classical gumshoe epidemiology" of "contact tracing and isolation" that brought swift action against the epidemic. Lipkin was ...
Three regions of the classical swine fever virus (CSFV) genome that have been widely sequenced were compared with respect to ... their ability to discriminate between isolates and to segregate viruses into genetic groups. Sequence data-sets were assembled ... Genetic typing of classical swine fever virus Vet Microbiol. 2000 Apr 13;73(2-3):137-57. doi: 10.1016/s0378-1135(00)00141-3. ... Three regions of the classical swine fever virus (CSFV) genome that have been widely sequenced were compared with respect to ...
... Author(s). Weesendorp, E.; Loeffen, W.L.A. ...
... Author(s). Smit, A.J. de; Bouma, A.; Terpstra, C.; ...
... regions of the classical swine fever virus (CSFV) were amplified by RT-PCR and sequenced directly from 158 specimens collected ... Phylogenetic analysis of classical swine fever virus in Taiwan Arch Virol. 2005 Jun;150(6):1101-19. doi: 10.1007/s00705-004- ... Two envelope glycoprotein (Erns and E2) regions of the classical swine fever virus (CSFV) were amplified by RT-PCR and ... Classical Swine Fever / virology* * Classical Swine Fever Virus / classification* * Classical Swine Fever Virus / genetics* ...
Immunological mechanisms of protection against classical swine fever virus: towards the development of new efficacious marker ... The high costs of a Classical Swine Fever (CSF) -outbreak, the social impact and resistance against destruction of pigs have ... virus transmission. The knowledge about relevant viral components, and about the quality of the vaccine-induced immune response ...
Classical swine fever virus (CSFV) is the causative agent of one of the most devastating porcine haemorrhagic viral diseases, ... Recent advances in the development of recombinant vaccines against classical swine fever virus: cellular responses also play a ... classical swine fever (CSF). CSFV mainly infects endothelial cells and macrophages and at the same time promotes bystander ... during which they either die or survive by producing neutralising antibodies to the virus. However, in a few cases, the ...
Reference Laboratory for classical swine fever offers one of the worlds largest semi-public virus-specific sequence ... The classical swine fever (CSF) DB (CSF-DB) became a valuable tool for supporting diagnosis and epidemiological investigations ... classical swine fever virus; sequence; database; disease control; classical swine fever ... Viruses 2016, 8, 302. AMA Style. Postel A, Schmeiser S, Zimmermann B, Becher P. The European Classical Swine Fever Virus ...
... border disease virus (BDV), and classical swine fever virus (CSFV), as well as a growing number of additional tentative ... Close Relationship of Ruminant Pestiviruses and Classical Swine Fever Virus. Emerging Infectious Diseases. 2015;21(4):668-672. ... Close Relationship of Ruminant Pestiviruses and Classical Swine Fever Virus On This Page ... Close Relationship of Ruminant Pestiviruses and Classical Swine Fever Virus. ...
Henke, Julia (2019): Protection against transplacental transmission of Classical swine fever virus using live marker vaccine " ... Protection against transplacental transmission of Classical swine fever virus using live marker vaccine "CP7_E2alf" ... Protection against transplacental transmission of Classical swine fever virus using live marker vaccine "CP7_E2alf" ...
Virus Adaptation and Selection Following Challenge of Animals Vaccinated against Classical Swine Fever Virus Viruses doi: ... Vaccines against classical swine fever have proven very effective in protecting pigs from this deadly disease. H... ... Virus Adaptation and Selection Following Challenge of Animals Vaccinated against Classical Swine Fever Virus Viruses doi: ... 11, Pages 932: Virus Adaptation and Selection Following Challenge of Animals Vaccinated against Classical Swine Fever Virus. * ...
Next Generation Sequencing of Classical Swine Fever Virus. In Workshop of the African and Classical Swine Fever National ... Next Generation Sequencing of Classical Swine Fever Virus. Workshop of the African and Classical Swine Fever National Reference ... Next Generation Sequencing of Classical Swine Fever Virus. In Workshop of the African and Classical Swine Fever National ... Next Generation Sequencing of Classical Swine Fever Virus. in Workshop of the African and Classical Swine Fever National ...
The virus is spread from infected or carrier pigs... ... 205) Swine fever is caused by one of the pesti family of ... viruses. The pig is the only natural host. ... Classical Swine Fever Virus (CSF) - Hog Cholera Virus (HC). See ... 205) Swine fever is caused by one of the pesti family of viruses. The pig is the only natural host. The virus is spread from ... When first introduced into the breeding herd it causes inappetence and high fevers. The virus can cross the placenta to invade ...
An Overview of the Immune Evasion Strategies Adopted by Different Viruses with Special Reference to Classical Swine Fever Virus ... 4. Few salient features about the disease Classical Swine Fever. Classical swine fever (CSF) is a disease of domestic pigs and ... An Overview of the Immune Evasion Strategies Adopted by Different Viruses with Special Reference to Classical Swine Fever Virus ... An Overview of the Immune Evasion Strategies Adopted by Different Viruses with Special Reference to Classical Swine Fever Virus ...
With classical swine fever virus (CSFV) commonplace in the world and barely outside the borders of North America, it is ... Development of classical swine fever virus diagnostic assays for porcine oral fluid samples. ... Possible use of a commercial blocking ELISA of classical swine fever antibody was also evaluated by using oral fluid samples ... Pilot study to develop ante-mortem synovial fluid and synovium sample collection techniques in growing swine and to refine a ...
The classical swine fever virus (CSFV) C-strain has been used as a vaccine strain for over 60 years in China. A recent study ... The role of noncoding regions of classical swine fever virus C-strain in its adaptation to the rabbit. Virus Res 183:117-122 ... The classical swine fever virus (CSFV) C-strain has been used as a vaccine strain for over 60 years in China. A recent study ... Chen N, Tong C, Li D, Wan J, Yuan X, Li X, Peng J, Fang W (2010) Antigenic analysis of classical swine fever virus E2 ...
Classical swine fever virus (CSFV), bovine viral diarrhea virus (BVDV), and border disease virus belong to the genus Pestivirus ... Virus-Cell Interactions. Inactivation of the RNase Activity of Glycoprotein Erns of Classical Swine Fever Virus Results in a ... RNase of classical swine fever virus: biochemical characterization and inhibition by virus-neutralizing monoclonal antibodies.J ... Classical swine fever virus: recovery of infectious viruses from cDNA constructs and generation of recombinant cytopathogenic ...
"Quasispecies composition and diversity do not reveal any predictors for chronic classical swine fever virus infection, Archives ... Passage of classical swine fever virus in cultured swine kidney cells selects virus variants that bind to heparan sulfate due ... Emergence of classical swine fever virus in Israel in 2009. David, D; Edri, N; Yakobson, BA; Bombarov, V; King, R; Davidson, I ... Genetic typing of classical swine fever virus. Paton, DJ; McGoldrick, A; Greiser-Wilke, I; Parchariyanon, S; Song, JY; Liou, PP ...
"Pathway analysis in blood cells of pigs infected with classical swine fever virus: comparison of pigs that develop a chronic ... Dynamics of virus excretion via different routes in pigs experimentally infected with classical swine fever virus strains of ... The Npro product of classical swine fever virus and bovine viral diarrhea virus uses a conserved mechanism to target interferon ... Mutations abrogating the RNase activity in glycoprotein E(rns) of the pestivirus classical swine fever virus lead to virus ...
Pigs immunized with a novel E2 subunit vaccine are protected from subgenotype heterologous classical swine fever virus ... Classical swine fever (CSF) or hog cholera is a highly contagious swine viral disease. CSF endemic countries have to use ... However, it is impossible to serologically differentiate MLV vaccinated pigs from those infected with CSF virus (CSFV). The aim ... did not show any fever, had low or undetectable level of CSFV in blood and nasal fluid. At the time of CSFV challenge, only ...
Effectiveness of the E2-Classical Swine Fever Virus Recombinant Vaccine Produced and Formulated within Whey from Genetically ... Subunit recombinant vaccines against classical swine fever virus (CSFV) are a promising alternative to overcome practical and ... Effectiveness of the E2-Classical Swine Fever Virus Recombinant Vaccine Produced and Formulated within Whey from Genetically ... Effectiveness of the E2-Classical Swine Fever Virus Recombinant Vaccine Produced and Formulated within Whey from Genetically ...
Classical swine fever virus induces oxidative stress in swine umbilical vein endothelial cells. Overview of attention for ... Classical swine fever virus induces oxidative stress in swine umbilical vein endothelial cells ...
Classical swine fever virus (CSFV) E2 glycoprotein was expressed in an alphavirus based replicon expression system. Vaccinated ... Classical swine fever virus (CSFV) E2 glycoprotein was expressed in an alphavirus based replicon expression system. Vaccinated ... "Development of an Alphavirus Replicon Classical Swine Fever Virus Vaccine Candidate," Animal Industry Report: AS 659, ASL R2752 ...
Hemoglobin subunit beta interacts with the capsid protein and antagonizes the growth of classical swine fever virus ... Hemoglobin subunit beta interacts with the capsid protein and antagonizes the growth of classical swine fever virus. Journal of ... which are permissive cells for classical swine fever virus (CSFV). Coimmunoprecipitation and confocal microscopy confirmed that ...
Pestiviruses such as classical swine fever virus (CSFV) and bovine viral diarrhea virus (BVDV) are some of the most ... Identification of cross-reactive epitope regions of bovine viral diarrhea virus and classical swine fever virus glycoproteins. ... Identification of cross-reactive epitope regions of bovine viral diarrhea virus and classical swine fever virus glycoproteins. ... Keywords: Immunology; Pestivirus; Epitope Mapping; Animal Diseases; Classical Swine Fever Virus; Bovine Viral Diarrhea Virus ...
... K-REx Repository. Search ... Complete genome sequence of a sub-subgenotype 2.1i isolate of classical swine fever virus from China. Zhang, B.; Mi, S.; Bao, F ... The complete genome sequence of a sub-subgenotype 2.1i isolate of classical swine fever virus (CSFV), GD317/2011, was ... Complete genome sequence of a sub-subgenotype 2.1i isolate of classical swine fever virus from China. Genome Announcements, 5( ...
Challenge of Pigs with Classical Swine Fever Viruses after C-Strain Vaccination Reveals Remarkably Rapid Protection and ... Challenge of Pigs with Classical Swine Fever Viruses after C-Strain Vaccination Reveals Remarkably Rapid Protection and ...
Characterization of virus-specific T cell cytokine responses following vaccination and challenge with classical swine fever ... of virus-specific T cell cytokine responses following vaccination and challenge with classical swine fever viruses In: Annual ...
... caused by CSF virus (CSFV) is a highly contagious disease of the pigs. A number of studies have suggested that CSFV non- ... FKBP8 interact with classical swine fever virus NS5A protein and promote virus RNA replication. Virus Genes. 2016;52:99-106. ... Classical swine fever virus NS5A protein interacts with 3-untranslated region and regulates viral RNA synthesis. Virus Res. ... Classical swine fever (CSF) caused by CSF virus (CSFV) is a highly contagious disease of the pigs. A number of studies have ...
The virus was highly contagious for the five pigs that were in direct contact with the inoculated pig, but spread to the other ... One pig in the middle pen of three adjacent pens was inoculated intramuscularly and intranasally with the virus. The fourth pen ... The first clinical signs observed after the virus was introduced into a pen were decreased feed intake, increased mean rectal ... The spread of the virus was promoted by contaminated clothing and footwear, but airborne transmission contributed considerably ...
... is a highly contagious fatal infectious disease caused by classical swine fever virus (CSFV). A better understanding of CSFV ... bovine viral diarrhea virus (BVDV), porcine parvovirus (PPV), porcine pseudorabies virus (PRV) and porcine circovirusII(PCV-2 ... With the development of novel RNA in situ Hybridization method, quantitatively localization and visualization of the virus RNA ... there was no cross-reaction with negative control and other viruses including BVDV, PPV, PRV and PCV-2. Our results showed that ...
  • Three regions of the classical swine fever virus (CSFV) genome that have been widely sequenced were compared with respect to their ability to discriminate between isolates and to segregate viruses into genetic groups. (nih.gov)
  • Two envelope glycoprotein (Erns and E2) regions of the classical swine fever virus (CSFV) were amplified by RT-PCR and sequenced directly from 158 specimens collected between 1989 and 2003 in Taiwan. (nih.gov)
  • Classical swine fever virus (CSFV) is the causative agent of one of the most devastating porcine haemorrhagic viral diseases, classical swine fever (CSF). (nih.gov)
  • To determine why serum from small ruminants infected with ruminant pestiviruses reacted positively to classical swine fever virus (CSFV)-specific diagnostic tests, we analyzed 2 pestiviruses from Turkey. (cdc.gov)
  • The genus Pestivirus comprises the established species bovine viral diarrhea virus (BVDV)-1, BVDV-2, border disease virus (BDV), and classical swine fever virus (CSFV), as well as a growing number of additional tentative Pestivirus species. (cdc.gov)
  • CSFV is the causative agent for classical swine fever, which is notifiable to the World Organisation of Animal Health because it is highly contagious and can cause great loss of pigs ( 2 - 4 ). (cdc.gov)
  • Of these, 11 serum samples from 7 sheep herds gave positive or doubtful reactions in the CSFV antibody-specific ELISA (HerdChek, IDEXX) and were subjected to commonly used virus neutralization testing (VNT) ( 7 ). (cdc.gov)
  • However, little is known about how vaccination impacts the selective pressures acting on the classical swine fever virus (CSFV). (medworm.com)
  • With classical swine fever virus (CSFV) commonplace in the world and barely outside the borders of North America, it is reasonable to expect that CSFV will eventually be reintroduced into North America. (pork.org)
  • Possible use of a commercial blocking ELISA of classical swine fever antibody was also evaluated by using oral fluid samples from a CSFV-free herd mixed with serially diluted known CSFV antibody titers as a pilot study and compared to the neutralizing peroxidase-linked assay (NPLA). (pork.org)
  • In addition, testing oral fluid samples using an improved sensitivity blocking ELISA may benefit the North American swine producers to rapidly identify premises infected with CSFV following its introduction into North America much faster than using the molecular diagnostic methods. (pork.org)
  • The classical swine fever virus (CSFV) C-strain has been used as a vaccine strain for over 60 years in China. (springer.com)
  • Envelope glycoprotein E rns of classical swine fever virus (CSFV) has been shown to contain RNase activity and is involved in virus infection. (asm.org)
  • The mutated proteins reacted with E rns -specific neutralizing monoclonal and polyclonal antibodies and were still able to inhibit infection of swine kidney cells (SK6) with CSFV, but at a concentration higher than that measured for intact E rns . (asm.org)
  • To study the effect of these mutations on virus infection and replication, a CSFV mutant with an inactivated E rns (FLc13) was generated with an infectious DNA copy of CSFV strain C. The mutant virus showed the same growth kinetics as the parent virus in cell culture. (asm.org)
  • Analyses of cellular DNA of swine kidney cells showed that the RNase-negative CSFV induced apoptosis. (asm.org)
  • Classical swine fever virus (CSFV), bovine viral diarrhea virus (BVDV), and border disease virus belong to the genus Pestivirus within the family Flaviviridae ( 10 ). (asm.org)
  • To elucidate the viral determinants, we analyzed the role of the viral populations for the development of chronic CSF virus (CSFV) infections. (deepdyve.com)
  • The three inocula represented sub-genogroups 2.1 and 2.3, and two viruses were wild-type CSFV, one derived from an infectious cDNA clone. (deepdyve.com)
  • However, it is impossible to serologically differentiate MLV vaccinated pigs from those infected with CSF virus (CSFV). (physiciansweekly.com)
  • It was found that while control pigs infected with CSFV stopped growing and developed high fever (>40 °C), high level CSFV load in blood and nasal fluid, and severe leukopenia 3-14 days post challenge, all KNB-E2 vaccinated pigs continued to grow as control pigs without CSFV exposure, did not show any fever, had low or undetectable level of CSFV in blood and nasal fluid. (physiciansweekly.com)
  • Subunit recombinant vaccines against classical swine fever virus (CSFV) are a promising alternative to overcome practical and biosafety issues with inactivated vaccines. (asm.org)
  • Previously we had demonstrated the efficacy of this antigen, which conferred early protection and long-lasting immunity in swine against CSFV infection. (asm.org)
  • Classical swine fever virus (CSFV) E2 glycoprotein was expressed in an alphavirus based replicon expression system. (iastate.edu)
  • In this study, hemoglobin subunit beta (HB) was identified as a C protein-binding protein by glutathione S-transferase pulldown and subsequent mass spectrometry analysis of PK-15 cells, which are permissive cells for classical swine fever virus (CSFV). (lancs.ac.uk)
  • Pestiviruses such as classical swine fever virus (CSFV) and bovine viral diarrhea virus (BVDV) are some of the most economically important livestock diseases in the world. (k-state.edu)
  • The antigenic similarities between members of the pestivirus genus allow for both BVDV and CSFV to infect swine. (k-state.edu)
  • Infections with heterologous pestiviruses in swine can interfere with diagnostic tests for CSFV. (k-state.edu)
  • The approach was to use serum neutralization assays to confirm the presence of neutralizing antibodies to BVDV in swine serum collected from animals immunized with one of three separate Alphavirus vaccine constructs: BVDV-1b, CSFV E2, and CSFV E[superscript]rns. (k-state.edu)
  • Classical swine fever (CSF) caused by CSF virus (CSFV) is a highly contagious disease of the pigs. (biomedcentral.com)
  • Hepatitis C virus (HCV) also belongs to the family of CSFV, and its protein NS5A has been intensely investigated. (biomedcentral.com)
  • Classical swine fever (CSF) is a highly contagious fatal infectious disease caused by classical swine fever virus (CSFV). (biomedcentral.com)
  • Specificity of the ViewRNA ISH was tested by detecting several sub genotypes of CSFV (sub genotype 1.1, 2.1, 2.2 and 2.3) which are present in China and other normal pig infectious virus (bovine viral diarrhea virus (BVDV), porcine parvovirus (PPV), porcine pseudorabies virus (PRV) and porcine circovirusII(PCV-2). (biomedcentral.com)
  • The ViewRNA ISH was specific for CSFV RNA including 1.1, 2.1, 2.2 and 2.3 subtypes, meanwhile, there was no cross-reaction with negative control and other viruses including BVDV, PPV, PRV and PCV-2. (biomedcentral.com)
  • The specificity experiment showed that the ViewRNA ISH was highly specific for CSFV and no cross-reaction occurred to negative control and other pig infectious virus. (biomedcentral.com)
  • Classical swine fever virus (CSFV) -specific cytotoxic T lymphocytes (CTL) were derived from peripheral blood mononuclear leukocytes of immunized NIH-minipigs (MHC d/d haplotype) after in vitro restimulation with infectious CSFV. (microbiologyresearch.org)
  • Their cytotoxic activity was determined against CSFV-infected target cells obtained from simian virus 40 (SV40) large T antigen-transfected immortalized kidney cells of a syngeneic miniature swine. (microbiologyresearch.org)
  • Infection of target cells with various vaccinia virus/CSFV recombinants led to the identification of a major antigenic site for CSFV-specific CTL near the cleavage site between the non-structural proteins p80 (NS3) and p10 (NS4a). (microbiologyresearch.org)
  • Self-replicating RNAs (replicons), with or without reporter gene sequences, derived from the genome of the Paderborn strain of classical swine fever virus (CSFV) have been produced. (microbiologyresearch.org)
  • E2 gene of classical swine fever virus (CSFV) was cloned into secretory pPIC9K Pichia pastoris expression vector. (semanticscholar.org)
  • The Lapinized Philippines Coronel (LPC) vaccine, an attenuated strain of classical swine fever virus (CSFV), is an important tool for the prevention and control of CSFV infection and is widely and routinely used in most CSF endemic areas, including Taiwan. (biomedcentral.com)
  • Following CSFV challenge, the LPC-vaccinated pigs pre-inoculated with PCV2 showed transient fever, viremia, and viral shedding in the saliva and feces. (biomedcentral.com)
  • Researchers have developed genetically modified pigs that are protected from Classical swine fever virus (CSFV), according to a study published in PLOS Pathogens by Hongsheng Ouyang of Jilin University, and colleagues. (star-idaz.net)
  • Classical swine fever virus (CSFV) causes severe disease in pigs associated with leukopenia, haemorrhage and fever. (microbiologyresearch.org)
  • Classical swine fever virus (CSFV) infects pigs and wild boar. (pirbright.ac.uk)
  • CSFV is an enveloped virus that has a capsid and single stranded RNA genome. (pirbright.ac.uk)
  • CSFV causes classical swine fever which is highly contagious. (pirbright.ac.uk)
  • Porcilis Pesti (Classical Swine Fever Virus (CSFV) -E2. (vetxed.com)
  • With vaccines having an importance in disease control, studies are seeking improved protein-based subunit vaccine against the virus (CSFV). (03964.com)
  • 1. INTRODUCTION Classical swine fever virus (CSFV), a member of the Pestivirus genus of the Flaviridae family, is an important worldwide cause of morbidity, mortality, and enormous economic losses in pig industries [12, 23]. (03964.com)
  • While eradication programmes based on stamping-out have been followed to eliminate classical swine fever (CSF) in many countries, these pig populations remain under constant threat, particularly where CSFV is enzootic in wild boars. (03964.com)
  • Recently, a new ovine pestivirus (OVPV), isolated from aborted lambs, with high genetic identity to classical swine fever virus (CSFV), has proved to induce reproductive disorders in pregnant ewes. (irta.cat)
  • Our findings show, for the first time, the OVPV capacity to infect swine, activate immunity, and the robust protection conferred against CSFV. (irta.cat)
  • In addition to their value as livestock, pigs are susceptible to classical swine fever virus (CSFV) and can serve as reservoirs for CSFV, allowing it to develop into an epizootic. (beds.ac.uk)
  • Cells from three MxA transgenic piglets were used to investigate in vitro antiviral activity of MxA aganist CSFV, and the results of in vitro indirect immunofluorescence assays, virus titration and real-time PCR indicated that the MxA transgenic pig has an antiviral capacity against CSFV. (beds.ac.uk)
  • Classical swine fever virus (CSFV) is a pestivirus of the Flaviviridae family [ 8 ] with an enveloped virion incorporating glycosylated membrane proteins. (beds.ac.uk)
  • Specific binding of seven SLA-1 proteins to one classical swine fever virus (CSFV) and four porcine reproductive and respiratory syndrome virus (PRRSV) epitope peptides was detected by enzyme-linked immunosorbent assay (ELISA)-based method. (frontiersin.org)
  • The cDNA of the nucleocapsid (core) protein of classical swine fever virus (CSFV) was generated by reverse transcription-polymerase chain reaction (RT-PCR) and cloned into a eukaryotic expression vector. (nchu.edu.tw)
  • Recently moderate-virulence classical swine fever virus (CSFV) strains have been proven capable of generating postnatal persistent infection (PI), defined by the maintenance of viremia and the inability to generate CSFV-specific immune responses in animals. (beds.ac.uk)
  • In this study, we assessed the infection generated in 7-week-old CSFV PI wild boars after infection with the African swine fever virus (ASFV). (beds.ac.uk)
  • Efficient live attenuated vaccines against classical swine fever virus (CSFV) are used routinely in endemic countries. (biomedcentral.com)
  • The CSF virus (CSFV), the etiological agent of CSF, is an icosahedral and enveloped positive stranded RNA virus that, together with bovine viral diarrhoea virus (BVDV) and border diseases virus, belongs to the Pestivirus genus of the Flaviviridae family [ 5 ]. (biomedcentral.com)
  • Classical swine fever (CSF), caused by classical swine fever virus (CSFV), has been epidemic or endemic in many countries, and causes great economical losses to pig industry worldwide. (bvsalud.org)
  • Classical swine fever virus (CSFV), is a Pestivirus in the Flaviviridae family. (frontiersin.org)
  • The Shimen strain of classical swine fever (CSF) virus (CSFV) causes CSF, which is mainly characterised by disseminated intravascular haemorrhage. (biomedcentral.com)
  • The Shimen strain of classical swine fever virus (CSFV) causes an especially infectious disease in domestic pigs known as classical swine fever (CSF), which has been listed as a highly contagious disease by the World Organisation for Animal Health [ 1 ]. (biomedcentral.com)
  • Classical swine fever virus (CSFV) causes a highly contagious disease among swine that has an important economic impact worldwide. (bvsalud.org)
  • CSFV strain LOM is an attenuated virus of low virulent strain of Miyagi isolated from Japan in 1956. (bvsalud.org)
  • For classical swine fever virus (CSFV), immunization with plasmids expressing different versions of glycoprotein E2 has proven an effective way to induce protection. (uab.cat)
  • Classical swine fever (CSF) is a worldwide devastating disease of the pig industry caused by classical swine fever virus (CSFV). (cdc.gov)
  • Outbreaks caused by the Classical Swine Fever Virus (CSFV) are currently controlled by stamping out of infected and neighbouring herds, as available live attenuated vaccines provide no means for discriminating between vaccinated and infected animals. (defra.gov.uk)
  • at 1-39 aa) of PCV2 capsid protein (Cap) with classical swine fever virus (CSFV) T-cell epitope (1446-1460 aa), CSFV B-cell epitope (693-716 aa) and CSFV T-cell epitope conjugated with B-cell epitope. (mdpi.com)
  • Classical swine fever (CSF) caused by CSF virus (CSFV) is a highly contagious and devastating disease of swine worldwide [ 1 , 2 ]. (mdpi.com)
  • To identify type-specific pestivirus antibodies, a liquid-phase peptide ELISA, with a labeled, specific classical swine fever virus (CSFV) peptide and an unlabeled bovine viral diarrhea virus peptide to block cross-reactivity, was developed. (asm.org)
  • CSFV is restricted to swine, whereas BVDV and BDV have been isolated from several species such as cattle, swine, sheep, deer, and giraffes ( 17 ). (asm.org)
  • The high costs of a Classical Swine Fever (CSF) -outbreak, the social impact and resistance against destruction of pigs have led to reconsideration of emergency vaccination against CSF. (europa.eu)
  • The classical swine fever (CSF) DB (CSF-DB) became a valuable tool for supporting diagnosis and epidemiological investigations of this highly contagious disease in pigs with high socio-economic impacts worldwide. (mdpi.com)
  • Accordingly, because of cross-reacting antibodies, infections of pigs (nonruminants) with ruminant pestiviruses, which occasionally occur under natural conditions, can cause serious problems with regard to serologic diagnosis of classical swine fever ( 5 ). (cdc.gov)
  • Viruses, Vol. 11, Pages 932: Virus Adaptation and Selection Following Challenge of Animals Vaccinated against Classical Swine Fever Virus Viruses doi: 10.3390/v11100932 Authors: Fahnøe Pedersen Johnston Orton Höper Beer Bukh Belsham Rasmussen Vaccines against classical swine fever have proven very effective in protecting pigs from this deadly disease. (medworm.com)
  • The virus is spread from infected or carrier pigs via discharges from the nose, mouth and the urine and faeces and it is highly contagious. (thepigsite.com)
  • BVDV and border disease virus can infect ruminants and pigs. (asm.org)
  • Höper, Dirk 2016-11-24 00:00:00 Classical swine fever (CSF) can run acute, chronic, and prenatal courses in both domestic pigs and wild boar. (deepdyve.com)
  • Pathway analysis in blood cells of pigs infected with classical swine fever virus: comparison of. (deepdyve.com)
  • Pigs immunized with a novel E2 subunit vaccine are protected from subgenotype heterologous classical swine fever virus challenge. (physiciansweekly.com)
  • Experimental infection of slaughter pigs with classical swine fever virus: transmission of the virus, course of the disease and antibody response. (semanticscholar.org)
  • The spread of classical swine fever virus was investigated in an isolation unit containing four pens, each containing six slaughter pigs. (semanticscholar.org)
  • Quantification of within- and between-pen transmission of Foot-and-Mouth disease virus in pigs. (semanticscholar.org)
  • An experimental infection to investigate the indirect transmission of classical swine fever virus by excretions of infected pigs. (semanticscholar.org)
  • This virus causes systemic hemorrhage in domestic pigs and leads to severe economic losses in the swine industry worldwide. (biomedcentral.com)
  • Porcilis Pesti is used to immunise healthy pigs from the age of 5 weeks onwards to prevent death and to reduce clinical signs of Classical Swine Fever (CSF). (vetxed.com)
  • The Committee for Medicinal Products for Veterinary Use (CVMP) agreed that the benefits of Porcilis Pesti are greater than any risks to immunise pigs from the age of 5 weeks onwards to prevent death and to reduce clinical signs of Classical Swine Fever. (vetxed.com)
  • Abstract C Classical swine fever (CSF) is a highly contagious and often fatal disease of pigs characterised by fever, severe leukopenia and haemorrhages. (03964.com)
  • Characterization of the binding specificity of peptides to SLA class I molecules provides an important basis for epitope studies of infectious diseases in swine, and for the rational development of novel porcine vaccines, as well as for detailed studies of CTL responses in pigs used as animal models. (frontiersin.org)
  • CROATIA - This is follow up report No.9 via OIE on the Classical Swine Fever outbreak in domestic pigs in Croatia. (thepigsite.com)
  • African swine fever (ASF), caused by African swine fever virus, is a hemorrhagic and often fatal disease of domestic pigs and wild boar, which is notifiable to the World Organization for Animal Health. (bioportfolio.com)
  • African swine fever virus causes a haemorrhagic fever in domestic pigs and wild boar. (bioportfolio.com)
  • Correction: Quantitative approach for the risk assessment of African swine fever and Classical swine fever introduction into the United States through legal imports of pigs and swine products. (bioportfolio.com)
  • The outbreak of respiratory illnesses in Mexico that began in March 2009 was caused by a swine origin influenza A (H1N1) virus (S-OIV) that had not been recognized previously in pigs or hu. (bioportfolio.com)
  • Here, we studied the immune response to a hog cholera lapinised virus vaccine (HCLV), C-strain, in six-week-old persistently infected pigs following post-natal infection. (biomedcentral.com)
  • Classical swine fever (CSF) is one of the most devastating diseases for the pig industry throughout the world affecting both domestic pigs and wild boars [ 1 , 2 ]. (biomedcentral.com)
  • Classical swine fever (CSF) remains one of the most economically important viral diseases of domestic pigs and wild boar worldwide. (frontiersin.org)
  • Subclinical signs such as intermittent fever and inappetence can be seen in chronically infected pigs, and although not life threatening, morbidity is still high ( 3 , 4 ). (frontiersin.org)
  • abstract = "Classical swine fever (CSF) is a highly contagious viral infection affecting domestic and wild pigs. (uab.cat)
  • A Kansas State University researcher has developed a method of producing a classical swine fever vaccine safely and inexpensively and has discovered specific antibodies that can be used to differentiate whether pigs are infected or vaccinated. (k-state.edu)
  • Classical swine fever has not been eliminated in China, and each of the 700 million pigs raised annually in the country currently receives two doses of vaccine against the virulent disease. (k-state.edu)
  • Pigs given the current modified live virus classical swine fever vaccine test positive for the disease. (k-state.edu)
  • Classical swine fever (CSF), also called hog cholera or swine fever, is a highly contagious viral disease of pigs. (iastate.edu)
  • Classical swine fever (CSF) is a highly contagious and economically significant viral disease of pigs. (usda.gov)
  • Signs of CSF vary with the strain of classical swine fever virus and the age and susceptibility of the pigs. (usda.gov)
  • Milder forms of virus or infection in partially immune pigs may exhibit mild or no symptoms and yet still harbor and spread the virus. (usda.gov)
  • Pigs that recover may shed virus for varying periods of time, serving as an infection risk to unaffected contact pigs. (usda.gov)
  • Outbreaks of classical swine fever (CSF) in the EU are controlled by eradication of all pigs from infected farms and farms in the vicinity. (asm.org)
  • On the back of recent claims from China and Vietnam that an African swine fever vaccine has been discovered, we speak to the head of the African swine fever group at The Pirbright Institute, Dr Linda Dixon, about the facts behind this claim and about the pioneering research that is currently going into the developing a vaccine that will save the lives of billions of pigs. (thepigsite.com)
  • We have shown that deleting several interferon inhibitory genes can produce a virus that doesn't cause disease but induces an immune response that protects pigs from disease caused by the deadly virus. (thepigsite.com)
  • These are being taken forward to develop vaccines by delivering pools of genes in safe virus vectors to pigs and determining which pools can induce an immune response that protects pigs against challenge with the deadly virus. (thepigsite.com)
  • Other researchers in Spain have also been working on ASF virus DNA, with recent studies showing that a naturally attenuated ASFv isolate from wild boar in Latvia can induce protection in pigs and wild boar, which suggests this could be a potential vaccine candidate. (thepigsite.com)
  • The latest victims of the African Swine Fever epidemic in China include a farm with almost 10,000 pigs in the. (pigprogress.net)
  • Most animals experience acute infection, during which they either die or survive by producing neutralising antibodies to the virus. (nih.gov)
  • The cowpox virus (CPV) complement inhibitor, termed inflammation modulatory protein (IMP), blocks immunopathological tissue damage at the site of infection, presumably by inhibiting production of the macrophage chemo attractant factors C3a and C5a. (intechopen.com)
  • However, the study of virus replication circle, particularly in the cell and viral RNA levels, can constitute an important basis for revealing the infection mechanism. (biomedcentral.com)
  • Classical swine fever virus induces proinflammatory cytokines and tissue factor expression and inhibits apoptosis and interferon synthesis during the establishment of long-term infection of porcine vascular endothelial cells. (microbiologyresearch.org)
  • It is also used to reduce infection with CSF and excretion of CSF virus into the environment. (vetxed.com)
  • The classical swine fever virus has the ability to cross the placental barrier, resulting in the infection of fetuses, which may consequently lead to persistent infection in piglets. (scite.ai)
  • For six weeks after postnatal infection, most of the piglets remained clinically healthy, despite persistent high virus titres in the serum, tissues, nasal and rectal swabs. (biomedcentral.com)
  • Real Time Analysis of Bovine Viral Diarrhea Virus (BVDV) Infection and Its Dependence on Bovine CD46. (nih.gov)
  • Within the Flaviviridae , infection dynamics have been analysed for DiD labelled Dengue virus, revealing diffusion patterns on the cell surface and the recruitment dynamics of endosomal components during virus entry 8 . (nature.com)
  • Feeding swine untreated food wastes containing infected pork scraps can cause infection, making raw garbage feeding a major risk for CSF incursion into swine herds. (usda.gov)
  • To discover biomarkers for severe dengue, we used surface-enhanced laser desorption/ionization time-of-flight mass spectrometry to analyze dengue virus positive serum samples from the acute phase of infection. (ajtmh.org)
  • Pathogenesis describes the spread of a virus in the organism and the mutual relationship between the pathogen and its host during infection. (springer.com)
  • Avian Influenza A Virus Infection among Workers at Live Poultry Markets, China, 2013-2016. (bioportfolio.com)
  • Recent advances in the development of recombinant vaccines against classical swine fever virus: cellular responses also play a role in protection. (nih.gov)
  • CSF endemic countries have to use routine vaccination with modified live virus (MLV) vaccines to prevent and control CSF. (physiciansweekly.com)
  • The potency of the E2 subunit vaccines is based mainly on induction of an effective humoral immune response, measurable as virus-neutralising antibodies [4, 5, 15, 37, 38]. (03964.com)
  • The use of antibodies in viral research is essential in the continuing efforts to develop vaccines and drug therapies for viruses. (antibodies-online.com)
  • This knowledge has been applied to the development of gene-deleted live attenuated African swine fever virus vaccines . (thepigsite.com)
  • Thiel HJ, Stark R, Weiland E, Rumenapf T, Meyers G (1991) Hog cholera virus: molecular composition of virions from a pestivirus. (springer.com)
  • Bovine viral diarrhoea virus (BVDV) is an economically important pathogen within the family Flaviviridae , genus Pestivirus and has been extensively used as a model for hepatitis C virus research. (nature.com)
  • Yet, the attachment and entry of BVDV or any other pestivirus has never been analysed in real time as suitable labelled viruses have been lacking to date. (nature.com)
  • Pestiviruses are enveloped viruses within the family Flaviviridae that have a highly variable single-stranded positive-sense RNA genome of ≈12.3 kb ( 1 ). (cdc.gov)
  • The genome of Rabies virus, Borna disease virus and Ebola virus code for the P phosphoprotein and VP35 that can block the antiviral response induced by IFN [ 8 , 9 , 10 ]. (intechopen.com)
  • Introductions of these viruses from humans and swine into southeast Mexico are indicated as groups of 8 horizontal lines, and each line represents 1 of 8 segments of the virus genome. (cdc.gov)
  • This insertion was well tolerated, resulting in a 2-fold drop in titer compared to the parental virus, and remained stably integrated into the genome for more than 10 passages. (nature.com)
  • These include reports describing virus morphology, the function and antigenic analysis of virus structural components, virus genome structure and expression, analysis on virus replication processes, virus evolution in connection with antiviral interventions, effects of viruses on their host cells, particularly on the immune system, and the pathogenesis of virus infections, including oncogene activation and transduction. (antibodies-online.com)
  • Pestiviruses are enveloped, plus-stranded RNA viruses whose genome comprises one long open reading frame ( 4 , 14 , 15 ). (asm.org)
  • More than 30 different subytypes of Influenza A Virus are available, like anti-Influenza A Virus (H5N1) . (antibodies-online.com)
  • We conducted a 3-year longitudinal serologic survey on an open cohort of poultry workers, swine workers, and general population controls to assess avian influenza A virus (AIV) seroprevalence and sero. (bioportfolio.com)
  • In vitro effect of classical swine fever virus on a porcine aortic endothelial cell line. (microbiologyresearch.org)
  • However, an approach using expression of recombinant porcine IFN, which inhibited foot and mouth disease in swine, was less successful when applied against CSF. (defra.gov.uk)
  • Porcine epidemic diarrhea virus (PEDV) is a highly effective pathogen that can cause death of new-born piglet, resulting in big economical loss in pig farming industry. (springer.com)
  • The specificity analysis results showed that this new ICA had no cross reaction in the presence of other porcine viruses. (springer.com)
  • Recent research has indicated that the human MxA protein inhibits the life cycles of certain RNA viruses, such as members of the Bunyaviridae family, the Flaviviridae family and others. (beds.ac.uk)
  • The viruses that comprise the Flaviviridae family are small enveloped, single-stranded, positive-sense RNA viruses. (asmscience.org)
  • Examination of interferon (IFN) signaling in infected cells has revealed strategies by which Flaviviridae members attenuate IFN-a/β receptor signaling actions, thus limiting the downstream expression of ISGs that otherwise control virus replication and spread. (asmscience.org)
  • Rumenapf T, Meyers G, Stark R, Thiel HJ (1991) Molecular characterization of hog cholera virus. (springer.com)
  • Moormann RJ, Warmerdam PA, van der Meer B, Schaaper WM, Wensvoort G, Hulst MM (1990) Molecular cloning and nucleotide sequence of hog cholera virus strain Brescia and mapping of the genomic region encoding envelope protein E1. (springer.com)
  • Antigenic comparisons of hog cholera virus isolates from Europe, America and Asia using monoclonal antibodies. (microbiologyresearch.org)
  • Laboratory tests include the identification of viral antigen, isolation of the virus and the presence of antibodies in serum. (thepigsite.com)
  • This recognition leads to the expression of cytokines, chemokines and co-stimulatory molecules that eliminate pathogens like viruses for the activation of antigen presenting cells and for the activation of specific adaptive response [ 4 ]. (intechopen.com)
  • Swine leukocyte antigen (SLA) class I molecules play a crucial role in generating specific cellular immune responses against viruses and other intracellular pathogens. (frontiersin.org)
  • Classical swine fever (CSF) or hog cholera is a highly contagious swine viral disease. (physiciansweekly.com)
  • The 'cleavage' activities of foot-and-mouth disease virus 2A site-directed mutants and naturally occurring '2A-like' sequences. (microbiologyresearch.org)
  • Classical swine fever is a notifiable disease and should be reported. (pirbright.ac.uk)
  • The severity of the disease can vary depending on the age of the pig, whether the pig has been exposed to the virus before and the virulence of the virus strain. (pirbright.ac.uk)
  • Foot-and-Mouth Disease and Swine Vesicular Disease Viruses. (wiley.com)
  • African swine fever (ASF) is a highly lethal haemorrhagic disease in domestic and wild swine that has acquired great importance in sub-Saharan Africa since 1997. (bioportfolio.com)
  • Disease is endemic in domestic swine in many African countries and Sardinia. (bioportfolio.com)
  • Classical swine fever (CSF) causes major losses in pig farming, with various degrees of disease severity. (biomedcentral.com)
  • Typically though the acute disease is characterized by high fever, inappetence, and general weakness followed by neurological deterioration, petechial hemorrhages of the skin, and splenic infarction ( 1 , 2 ). (frontiersin.org)
  • Kawanishi N , Tsuduku S , Shimizu H , Ohtani Y , Kameyama K , Yamakawa M , First isolation of border disease virus in Japan is from a pig farm with no ruminants. (cdc.gov)
  • Oguzoglu TC , Tan MT , Toplu N , Demir AB , Bilge-Dagalp S , Karaoglu T , Border disease virus (BDV) infections of small ruminants in Turkey: a new BDV subgroup? (cdc.gov)
  • Thabti F , Letellier C , Hammami S , Pepin M , Ribiere M , Mesplede A , Detection of a novel border disease virus subgroup in Tunisian sheep. (cdc.gov)
  • This means that it is safe to work with highly contagious animal diseases such as foot-and-mouth disease and classical swine fever. (wur.nl)
  • MANHATTAN - A Kansas State University researcher has licensed a new vaccine to an animal health company to fight a highly contagious swine disease overseas. (k-state.edu)
  • Classic swine fever, ARS discoveries are providing vital information to help fight this economically devastating disease, which affects cattle and other cloven-hoofed animals. (invasivespeciesinfo.gov)
  • While classical swine fever does not cause foodborne illness in people, economic losses to pork producers would be severe if the disease were to become established again in this country. (invasivespeciesinfo.gov)
  • Although classical swine fever was once widespread, many countries have eradicated this disease from domesticated swine. (usda.gov)
  • Classical swine fever should be reported immediately upon diagnosis or suspicion of the disease. (usda.gov)
  • African Swine Fever, Vesicular Stomatitis Virus, Classical Swine Fever and Foot-and-Mouth Disease Virus. (usda.gov)
  • The disease is characterized by fever and leukopenia and can run an acute, chronic, or subclinical course. (asm.org)
  • In both cases, the host organism responds with immunological defence responses, which usually lead to overcoming the primary disease symptoms and to the elimination of the virus. (springer.com)
  • Antivirals could play a role in reducing virus replication and hence slowing down or stopping the spread of that disease," she says. (thepigsite.com)
  • It offers a compilation of descriptive reviews regarding the mechanisms of viral replication as implemented to several viruses of crucial significance to animal or human disease. (indigo.ca)
  • Taking advantage of a previously described site within the structural protein E2, a fluorophore was introduced into a cytopathogenic (cpe) BVDV-1 virus (BVDV E2_fluo ). (nature.com)
  • Genetic characterization of African swine fever virus in Cameroon, 2010-2018. (bioportfolio.com)
  • Home Illinois Swine Technical Articles Effect on growth performance and bone mineralization of GraINzyme phytase in diets. (swineweb.com)
  • To further identify the contributions of the glycoproteins to rabbit adaptation, a series of C-strain-based chimeric viruses containing single or double glycoprotein substitutions of the Shimen strain were generated and inoculated into rabbits. (springer.com)
  • Although chronic infections are rare events, their epidemiological impact is very high due to the long-term shedding of virus. (deepdyve.com)
  • Neighbourhood infections of classical swine fever during the 1997-1998 epidemic in The Netherlands. (semanticscholar.org)
  • Trends in Emerging Viral Infections of Swine includes sections on global trade, vaccination regimens against new and emerging viruses, epidemiology and control, as well as significant new outbreaks like the West Nile virus. (wiley.com)
  • One area of importance in this respect is the induction of virus-specific cytotoxic T lymphocytes (CTL), an important defence mechanism against non-cytopathogenic virus infections such as CSF. (03964.com)
  • This knowledge will be invaluable for the development of intervention strategies that seek to manipulate the host's innate immune response to prevent the virus from initiating new infections. (defra.gov.uk)
  • Clinical and Serological Evaluation of LINDA Virus Infections in Post-Weaning Piglets. (nih.gov)
  • In Brasier A, García-Sastre A, Lemon S (ed), Cellular Signaling and Innate Immune Responses to RNA Virus Infections . (asmscience.org)
  • Nevertheless, to exist as a species, virus replication and transfer to a new host are essential. (intechopen.com)
  • We conclude that the RNase activity of envelope protein E rns plays an important role in the replication of pestiviruses and speculate that this RNase activity might be responsible for the persistence of these viruses in their natural host. (asm.org)
  • Discoveries concerning new virus structure, replication, pathogenesis and evolution are elemental to understand the work mechanisms and possible treatments. (antibodies-online.com)
  • Antibodies-online offers ELISA kits and antibodies for research of over 150 viral targets and virus like particles to assist researchers investigating virus structure, replication, pathogenesis and evolution . (antibodies-online.com)
  • 1918 pandemic influenza virus - reconstructed replication competent forms containing any portion of the coding regions of all 8 gene segments. (ufl.edu)
  • Profiles of rectal temperature, viral RNA, E2 protein expression, and antibody responses were compared among the chimeric viruses. (springer.com)
  • However, substitution of both E rns and E2 in the C-strain backbone abolished fever response, and the chimeric virus did not show adaptation in rabbits as demonstrated by lack of viral RNA and E2 protein expression in the spleen and weak antibody responses. (springer.com)
  • The expression of classical swine fever virus structural protein E2 gene in tobacco chloroplasts for applying chloroplasts as bioreactors. (semanticscholar.org)
  • This NLS mediates the nuclear accumulation of MxA, whereas the swine Mx1 protein is not located inside nucleus for lack of NLS. (beds.ac.uk)
  • Cloning, expression and sequence analysis of the classical swine fever virus nucleocapsid protein / Liu, J.J. (nchu.edu.tw)
  • Cloning, Expression and Sequence Analysis of the Classical Swine Fever Virus Nucleocapsid Protein. (nchu.edu.tw)
  • All the identified virus isolates were classified as ASFV genotype I based on the partial B646L gene (C-terminal end of VP72 gene) and the full E183L gene encoding p54 protein analysis. (bioportfolio.com)
  • Most viruses have multiple mechanisms that antagonise the innate immune system and this objective also aims to investigate the involvement of another viral protein in pathogenesis and virulence. (defra.gov.uk)
  • Shi's vaccine uses a protein from the virus rather than live or attenuated virus, which means the vaccine poses no biosecurity risk to produce in the U.S., where classical swine fever was eradicated in 1978. (k-state.edu)
  • The fluorophore E2 fusion protein was readily detectable in purified virus particles by Western blot and fluorescence microscopy and the particle integrity and morphology was confirmed by cryo electron microscopy. (nature.com)
  • To gain dynamic information of virus entry, viruses can be genetically labelled by the fusion of a structural protein with a fluorophore or by labelling components of intact virus particles with a fluorescent dye (e.g. adenovirus/enveloped particles with DiD) (reviewed in 7 ). (nature.com)
  • The purpose of this study is to determine whether immune globulin can limit the amount of yellow fever vaccine virus present in the blood after vaccination without compromising the immunit. (bioportfolio.com)
  • In a recent update of the Dutch contingency plan for controlling outbreaks of classical swine fever (CSF), emergency vaccination is preferred to large-scale pre-emptive culling. (royalsocietypublishing.org)
  • Here, we integrate quantitative information available on CSF virus transmission and vaccination effects into a stochastic mathematical model that describes the transmission dynamics at the level of animals, farms and livestock areas. (royalsocietypublishing.org)
  • Early in June 2019, reports emerged from China that shopping mall operator Guangdong Highsun Group Co had announced it was backing the development of an African swine fever vaccine. (thepigsite.com)
  • This effect could be neutralized by rescue of the inactivated E rns gene and by neutralizing polyclonal antibodies directed against E rns , indicating that this effect was an inherent property of the RNase-negative virus. (asm.org)
  • EU diagnostic manual for classical swine fever (CSF) diagnosis: technical part. (cdc.gov)
  • These two viruses have led to complications in clinical diagnosis. (springer.com)
  • If the amino acid motif is similar to that observed for other HPAI isolates, then the isolate being tested should be considered HPAI and the virus is controlled for export. (ufl.edu)
  • Introduction of genotype 8 viruses is indicated. (cdc.gov)
  • Nevertheless, animals inoculated with an E2 subunit vaccine are unable to prevent horizontal and vertical spread of the virus [11]. (03964.com)
  • The second objective of this project is to establish the role that this and other viral proteins have in the pathogenesis and virulence of the virus by identifying host proteins that the viral proteins interact with. (defra.gov.uk)
  • Replacement of E rns , E2, E rns -E2, or E1-E2 of the C-strain with the counterpart(s) of the Shimen strain led to decreased fever response, reduction of viral RNA and antibody responses in rabbits, as compared with their parental C-strain. (springer.com)
  • Our second approach for vaccine development involves identifying which of the viruses 170 genes code for proteins that are immunogenic and can induce a cellular or antibody response. (thepigsite.com)
  • African Swine Fever Virus. (wiley.com)
  • African swine fever: an unprecedented disaster and challenge to China. (bioportfolio.com)
  • The continuing spread of African swine fever (ASF) outside Africa in Europe, the Russian Federation, China and most recently to Mongolia and Vietnam, has heightened awareness of the threat posed by th. (bioportfolio.com)
  • How close are we to developing a vaccine for African swine fever? (thepigsite.com)
  • We speak to the head of the African swine fever group at The Pirbright Institute about the hard work going into developing a vaccine that could protect the global pig herd from a deadly foe. (thepigsite.com)
  • The Pirbright Institute have their very own African swine fever group who are certainly making progress in their ASF vaccine research. (thepigsite.com)
  • A pig suffering from Classical Swine Fever - in signs indistinguishable from African Swine Fever. (pigprogress.net)
  • Classical Swine Fever, although partly identical in name and clinical signs to African Swine Fever, is caused by a completely different virus than its namesake that is being found in increasingly more cases in China these days. (pigprogress.net)
  • The number of reported African Swine Fever (ASF) outbreaks in China has continued to rise to 74 while also the. (pigprogress.net)
  • Updates with regard to African Swine Fever (ASF) are coming in at a high pace this week. (pigprogress.net)
  • Outbreaks of classical swine fever (CSF) can lead to large economic losses and have a major impact on animal welfare. (royalsocietypublishing.org)
  • Molecular epidemiology studies in these regions suggests that the virus circulating in the field has evolved under the positive selection pressure exerted by the immune response to the vaccine, leading to new attenuated viral variants. (biomedcentral.com)
  • Moennig V , Floegel-Niesmann G , Greiser-Wilke I . Clinical signs and epidemiology of classical swine fever: a review of new knowledge. (cdc.gov)
  • A contributor to Diseases of Swine, 8th edition, Dr. Zimmerman has selected three additional editors with international expertise. (wiley.com)
  • We have versatile animal facilities that allow studies on infectious diseases caused by bacteria, viruses, parasites and prions. (wur.nl)
  • Topics include all priority livestock and aquaculture infectious diseases (including those caused by viruses, bacteria, pests, parasites) and non-infectious diseases. (bovinevetonline.com)
  • Classical swine fever is one of the diseases that will be studied at NBAF, and we're proud to be supporting progress in fighting this economic threat to pork production worldwide. (k-state.edu)
  • The range of clinical signs and its clinical similarity to other diseases can make classical swine fever challenging to diagnose. (usda.gov)
  • The Npro product of classical swine fever virus interacts with I?B? (pirbright.ac.uk)
  • Monocistronic mRNAs containing defective hepatitis C virus-like picornavirus internal ribosome entry site elements in their 5′ untranslated regions are efficiently translated in cells by a cap-dependent mechanism. (microbiologyresearch.org)
  • Identification of determinants involved in initiation of hepatitis C virus RNA synthesis by using intergenotypic replicase chimeras. (microbiologyresearch.org)
  • Hepatitis C virus (HCV) is now the most common cause of liver failure and liver transplantation in the United States and Europe. (asmscience.org)
  • The C-strain-based chimeric virus expressing the Shimen strain E1 exhibited typical fever response and viral RNA level similar to the C-strain. (springer.com)
  • Qiu HJ, Tong GZ, Shen RX (2005) The lapinized Chinese strain of classical swine fever virus: a retrospective review spanning half a century. (springer.com)
  • Wu HX, Wang JF, Zhang CY, Fu LZ, Pan ZS, Wang N, Zhang PW, Zhao WG (2001) Attenuated lapinized chinese strain of classical swine fever virus: complete nucleotide sequence and character of 3′-noncoding region. (springer.com)
  • Li C, Li Y, Shen L, Huang J, Sun Y, Luo Y, Zhao B, Wang C, Yuan J, Qiu HJ (2014) The role of noncoding regions of classical swine fever virus C-strain in its adaptation to the rabbit. (springer.com)
  • Effect of strain and inoculation dose of classical swine fever virus on within-pen transmission. (semanticscholar.org)
  • HoJo virus (HOJOV) A strain of Hantaan virus in the genus Hantavirus, recovered from the blood of a patient with Korean hemorrhagic fever. (rrnursingschool.biz)
  • In contrast to the classical (non-marker) C-strain vaccine, this marker vaccine has the advantage that the accompanying serological test can discriminate between infected and vaccinated animals. (royalsocietypublishing.org)
  • The severity of the illness varies with the strain of the virus, the age of the pig, and the immune status of the herd. (usda.gov)
  • A species of gram-negative, rod-shaped bacteria isolated from the intestinal tract of swine, poultry, and man. (bioportfolio.com)
  • Genus Tequatrovirus ( T4virus , T4-ähnliche Viren , en. (wikipedia.org)
  • You need info about Classical Swine Fever Virus Anitibody ELISA Kit or any other Gentaur produtct? (gentaurshop.com)
  • Cryo EM structure of the rabies virus ribonucleoprotein complex. (nih.gov)
  • The objective of this project is to understand the immune mechanisms underlying protection against CSF, in particular the mechanisms involved in early protection against clinical signs of CSF and in the reduction of (horizontal) virus transmission. (europa.eu)
  • Comparison of viraemia- and clinical-based estimates of within- and between-pen transmission of classical swine fever virus from three transmission experiments. (semanticscholar.org)
  • no clinical signs or virus transmission to sentinel animals were observed after 35 days. (bvsalud.org)
  • Unfortunately, due to the fact that PEDV and a different Alphacoronavirus, transmissible gastroenteritis virus (TGEV), have the same epidemiological and clinical features. (springer.com)
  • These processes are associated with the production of antigenic proteins that make the virus vulnerable to immune control mechanisms 'warning' the host of the presence of an invader [ 1 ]. (intechopen.com)
  • During the period of coexistence with their hosts, viruses have learned how to manipulate host immune control mechanism. (intechopen.com)
  • The present review will highlight the different complex mechanisms associated with the host immune evasion by the viruses with special reference to the Classical Swine Fever Virus. (intechopen.com)
  • There are certain cellular components which are manipulated by viruses to evade the innate immune response. (intechopen.com)
  • Indeed, recent studies on CSF indicate an important role for cellmediated immune responses in protection against the virus [31]. (03964.com)
  • However the Classical Swine Fever Virus is able to avoid the innate immune system. (defra.gov.uk)
  • The aim of this proposal is to further our understanding of the mechanisms by which the virus is able to avoid these innate immune response. (defra.gov.uk)
  • Pestiviruses are small, enveloped, positive-stranded RNA viruses ( 23 ). (asm.org)
  • To assess the capacity of OVPV to infect swine, twelve piglets were infected either by intranasal or intramuscular route. (irta.cat)
  • Dengue virus is an arbovirus transmitted by mosquitoes which causes significant morbidity and mortality among children in tropical regions, especially in resource limited countries. (bioportfolio.com)
  • The database (DB) of the European Union (EU) and World Organisation for Animal Health (OIE) Reference Laboratory for classical swine fever offers one of the world's largest semi-public virus-specific sequence collections combined with a module for phylogenetic analysis. (mdpi.com)
  • Postel A , Schmeiser S , Bernau J , Meindl-Boehmer A , Pridotkas G , Dirbakova Z , Improved strategy for phylogenetic analysis of classical swine fever virus based on full-length E2 encoding sequences. (cdc.gov)
  • Avian influenza viruses of the H5 or H7 subtype that do not have either of the characteristics described above should be sequenced to determine whether multiple basic amino acids are present at the cleavage site of the haemagglutinin molecule (HAO). (ufl.edu)
  • The Classical Swine Fever (CSF) Surveillance Program is designed to enhance surveillance for the rapid detection of CSF virus introduced into U.S. swine by testing targeted swine populations in high risk states. (usda.gov)