DiseasesChemicals and Drugs
Classical Lissencephalies and Subcortical Band HeterotopiasLissencephalyNeuronal Migration DisordersCobblestone LissencephalyNeuropeptidesChoristomaPeriventricular Nodular HeterotopiaNervous System Malformations
Classical Lissencephalies and Subcortical Band Heterotopias
Disorders comprising a spectrum of brain malformations representing the paradigm of a diffuse neuronal migration disorder. They result in cognitive impairment; SEIZURES; and HYPOTONIA or spasticity. Mutations of two genes, LIS1, the gene for the non-catalytic subunit of PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE IB; and DCX or XLIS, the gene for doublecortin, have been identified as the most common causes of disorders in this spectrum. Additional variants of classical (Type I) lissencephaly have been linked to RELN, the gene for reelin, and ARX, the gene for aristaless related homeobox protein. (From Leventer, R.J., et al, Mol Med Today. 2000 Jul;6(7):277-84 and Barkovich, A.J., et al, Neurology. 2005 Dec 27;65(12):1873-87.)
Lissencephaly
A "smooth brain" malformation of the CEREBRAL CORTEX resulting from abnormal location of developing neurons during corticogenesis. It is characterized by an absence of normal convoluted indentations on the surface of the brain (agyria), or fewer and shallower indentations (pachygryia). There is a reduced number of cortical layers, typically 4 instead of 6, resulting in a thickened cortex, and reduced cerebral white matter that is a reversal of the normal ratio of cerebral white matter to cortex.
Neuronal Migration Disorders
Disorders resulting from defects in migration of neuronal cells during neurogenesis. Developing nerve cells either fail to migrate or they migrate to incorrect positions resulting in formation of heterotopias, lissencephaly, or other malformations and dysfunctions of the nervous system.
Cobblestone Lissencephaly
The smooth pebbled appearance of the CEREBRAL CORTEX with a thickened cortex and reduced and abnormal white matter, which results from migration of heterotopic neurons beyond the marginal zone into the leptomeninges through gaps in the external BASEMENT MEMBRANE. There is also enlarged ventricles, underdeveloped BRAINSTEM and cerebellum, and absence of the CORPUS CALLOSUM. These abnormalities occur as a syndrome without other birth defects (cobblestone complex) or in other syndromes associated with congenital MUSCULAR DYSTROPHY, often involving the eye, such as the Walker-Warburg Syndrome, Fukuyama congenital muscular dystrophy, and muscle-eye-brain disease.
Neuropeptides
Peptides released by NEURONS as intercellular messengers. Many neuropeptides are also hormones released by non-neuronal cells.
Choristoma
A mass of histologically normal tissue present in an abnormal location.
Periventricular Nodular Heterotopia
A disorder resulting from a defect in the pattern of neuronal migration in which ectopic collections of neurons lie along the lateral ventricles of the brain or just beneath, contiguously or in isolated patches.
Nervous System Malformations
Structural abnormalities of the central or peripheral nervous system resulting primarily from defects of embryogenesis.

The structure of the coiled-coil domain of Ndel1 and the basis of its interaction with Lis1, the causal protein of Miller-Dieker lissencephaly. (1/12)

Ndel1 and Nde1 are homologous and evolutionarily conserved proteins, with critical roles in cell division, neuronal migration, and other physiological phenomena. These functions are dependent on their interactions with the retrograde microtubule motor dynein and with its regulator Lis1--a product of the causal gene for isolated lissencephaly sequence (ILS) and Miller-Dieker lissencephaly. The molecular basis of the interactions of Ndel1 and Nde1 with Lis1 is not known. Here, we present a crystallographic study of two fragments of the coiled-coil domain of Ndel1, one of which reveals contiguous high-quality electron density for residues 10-166, the longest such structure reported by X-ray diffraction at high resolution. Together with complementary solution studies, our structures reveal how the Ndel1 coiled coil forms a stable parallel homodimer and suggest mechanisms by which the Lis1-interacting domain can be regulated to maintain a conformation in which two supercoiled alpha helices cooperatively bind to a Lis1 homodimer.  (+info)

Characterization of the HeCo mutant mouse: a new model of subcortical band heterotopia associated with seizures and behavioral deficits. (2/12)

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Intragenic deletions and duplications of the LIS1 and DCX genes: a major disease-causing mechanism in lissencephaly and subcortical band heterotopia. (3/12)

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Comparing two diagnostic laboratory tests for several microdeletions causing mental retardation syndromes: multiplex ligation-dependent amplification vs fluorescent in situ hybridization. (4/12)

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Independent component analysis reveals dynamic ictal BOLD responses in EEG-fMRI data from focal epilepsy patients. (5/12)

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Role of cytoskeletal abnormalities in the neuropathology and pathophysiology of type I lissencephaly. (6/12)

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Disturbances in the positioning, proliferation and apoptosis of neural progenitors contribute to subcortical band heterotopia formation. (7/12)

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Miller-Dieker syndrome with der(17)t(12;17)(q24.33;p13.3)pat presenting with a potential risk of mis-identification as a de novo submicroscopic deletion of 17p13.3. (8/12)

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Subcortical band heterotopia: MedlinePlus GeneticsSubcortical band heterotopia: MedlinePlus Genetics
The inheritance pattern of subcortical band heterotopia depends on its genetic cause.. When subcortical band heterotopia is caused by mutations in the DCX gene, it is inherited in an X-linked pattern. The DCX gene is located on the X chromosome, which is one of the two sex chromosomes. In females, who have two copies of the X chromosome, one altered copy of the gene in each cell can lead to the condition, sometimes with less severe symptoms than affected males. In males, who have only one X chromosome, a mutation in the only copy of the gene in each cell usually causes a more severe condition called isolated lissencephaly sequence (ILS). Most males with subcortical band heterotopia have a DCX gene mutation that is not inherited and is present in only some of the bodys cells, a situation known as mosaicism. A characteristic of X-linked inheritance is that fathers cannot pass X-linked traits to their sons.. When subcortical band heterotopia is caused by a PAFAH1B1 gene mutation, it is generally ...
https://medlineplus.gov/genetics/condition/subcortical-band-heterotopia/
What is Lissencephaly?What is Lissencephaly?
Lissencephaly represents a developmental disorder resulting from abnormal neuronal migration. A wide spectrum of cerebral pathology can be seen in lissencephaly - from pachygyria and agyria (reduction and absence of cerebral convolutions, respectively) to subcortical band heterotopia where cerebral convolutions appear normal.
https://www.news-medical.net/health/What-is-Lissencephaly.aspx
Lissencephaly | Radiology Case | Radiopaedia.orgLissencephaly | Radiology Case | Radiopaedia.org
Lissencephaly type I is a heterogeneous group of disorders of cortical formation characterised by a smooth brain, with absent or hypoplastic sulci and is strongly associated with subcortical band heterotopia (see classification system for cortica...
https://radiopaedia.org/cases/lissencephaly-5
About Roberta : ASEK Diet: acidosis-sparing euketonemic ketogenic dietAbout Roberta : ASEK Diet: acidosis-sparing euketonemic ketogenic diet
Roberta Nicole Abady is a 46-year old woman with diagnoses of epilepsy associated with subcortical band heterotopia (double cortex syndrome), a mild degree of lissencephaly (smooth brain), and autism spectrum disorder (ASD). Her developmental years were devastated by continual seizures of multiple types (Lennox-Gastaut Syndrome) that impaired her ability to develop age-appropriate cognitive and social skills. Therapeutic dietary management started with a series of unsuccessful experiments: Atkins diet (1996), Johns Hopkins protocol ketogenic diet (1997), low glycemic index diet (1998). Despite her very low seizure threshold, Robertas current regimen protects against break-through seizures and supports excellent health.. ...
http://www.asekdiet.com/current-diet-plan/
Case History : ASEK Diet: acidosis-sparing euketonemic ketogenic dietCase History : ASEK Diet: acidosis-sparing euketonemic ketogenic diet
RA is a 41 yr. old female with subcortical band heterotopia. She had autism and seizures with multiple atypical seizure types which started when she was 9 months old. She was first hospitalized for status epilepticus (SE) at age 13. Her seizures remained refractory on various AED combinations. She had 8 further admissions because of SE, the last SE and hospitalization occurring at age 33. RA started ketogenic dietary treatment at age 27. Her dietary management has evolved over a period of 14 years. Her ketogenic diet has been modified for improved nutritional support, reduction of metabolic acidosis, avoidance of neurotoxins, and protection of mitochondrial and peroxisomal beta-oxidation pathways. Since age 33 years RA has been without overt episode of seizure of either a clearly defined complex partial or secondary generalized nature. EEG at age 35 was essentially normal. Primary treatment consists of phenytoin, maintained at maximum therapeutic level, high dose levetiracetam, and ...
http://www.asekdiet.com/case-history/
Miller-Dieker syndromeMiller-Dieker syndrome
Miller-Dieker syndrome is a genetic condition characterized by lissencephaly, typical facial features, and severe neurologic abnormalities. Symptoms may include severe intellectual disability, developmental delay, seizures, muscle stiffness, weak muscle tone and feeding difficulties. Miller-Dieker syndrome is caused by a deletion of genetic material near the end of the short (p) arm of chromosome 17. Treatment is symptomatic and supportive ...
http://www.diseaseinfosearch.org/result/4816
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From our preliminary observation, it appears that GE cavitations are an aspect of more complex conditions associated with severe cerebral structural derangement. The awareness of this rare developmental abnormality involving the GE region may have implications in better understanding of the complex malformations caused by defective cellular proliferation and migration, such as lissencephalies. The fact that the lesions were bilateral and symmetric with an inverted regular open C shape, an epithelium-like lining, regular margins, and no apparent signs of hemorrhage (including the 2 cases with T1-weighted images) suggests a malformative rather than necrotic-clastic origin. Familial recurrence in 2 cases and the presence of frontal band heterotopias in 1 case further support such a hypothesis. Although the data are not extensive enough to conclude a statistical significance, the available ADC values (cases 1 and 4), albeit showing a slight trend toward mild reduction (0.85 SD, 0.09 m2/s), ...
http://www.ajnr.org/content/34/9/1841
Miller-Dieker Syndrome | SpringerLinkMiller-Dieker Syndrome | SpringerLink
In 1963, Miller reported two siblings with a specific pattern of malformations in which lissencephaly was a key feature. Later in 1969, Dieker et al. described a similar condition. Jones et al. in ...
https://link.springer.com/referenceworkentry/10.1007/978-1-4614-6430-3_157-2
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Lissencephaly disease: Malacards - Research Articles, Drugs, Genes, Clinical TrialsLissencephaly disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials
NIH Rare Diseases : 50 the following summary is from orphanet, a european reference portal for information on rare diseases and orphan drugs.orpha number: 48471disease definitionthe term lissencephaly covers a group of rare malformations sharing the common feature of anomalies in the appearance of brain convolutions (characterised by simplification or absence of folding) associated with abnormal organisation of the cortical layers as a result of neuronal migration defects during embryogenesis.epidemiologythe incidence of all forms of type i lissencephaly is around 1 in 100,000 births.clinical descriptionchildren with lissencephaly have feeding and swallowing problems, muscle tone anomalies (early hypotonia and subsequently limb hypertonia), seizures (in particular, infantile spasms) and severe psychomotor retardation. multiple forms of lissencephaly have been described and their current classification is based on the associated malformations and underlying aetiology. two large groups can be ...
http://www.malacards.org/card/lissencephaly
Neuronal Migration DisorderNeuronal Migration Disorder
Neuronal migration disorder refers to a group of disorders that arise from the abnormal migration of nerve cells during embryonic development. If the migration of neuroblasts is disturbed during neurogenesis, neural circuits do not form properly in the correct parts of the brain. This is referred to as cerebral dysgenesis.
https://www.news-medical.net/health/Neuronal-Migration-Disorder.aspx
VLDL receptor - WikipediaVLDL receptor - Wikipedia
The very-low-density-lipoprotein receptor (VLDLR) is a transmembrane lipoprotein receptor of the low-density-lipoprotein (LDL) receptor family. VLDLR shows considerable homology with the members of this lineage. Discovered in 1992 by T. Yamamoto, VLDLR is widely distributed throughout the tissues of the body, including the heart, skeletal muscle, adipose tissue, and the brain, but is absent from the liver. This receptor has an important role in cholesterol uptake, metabolism of apoprotein-E-containing triacylglycerol-rich lipoproteins, and neuronal migration in the developing brain. In humans, VLDLR is encoded by the VLDLR gene. Mutations of this gene may lead to a variety of symptoms and diseases, which include type I lissencephaly, cerebellar hypoplasia, and atherosclerosis. VLDLR is a member of the low-density-lipoprotein (LDL) receptor family, which is entirely composed of type I transmembrane lipoprotein receptors. All members of this family share five highly conserved structural domains: ...
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DCLK2 Full-Length MS Protein Standard - Creative ProteomicsDCLK2 Full-Length MS Protein Standard - Creative Proteomics
DCLK2 Full-Length MS Protein Standard (NP_001035350), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that the DCX gene, another family member, and this gene share function in the establishment of
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State Pharmacy: New Forms Of Viagra huge sales online!State Pharmacy: New Forms Of Viagra huge sales online!
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International Journal of Research in Health SciencesInternational Journal of Research in Health Sciences
Introduction: Heterotopias, which are also referred to as choristomas and ectopias, are characterized by the presence of normal-appearing tissue in an anatomical location in which they are normally not found. Clinicopathological aspects of Heterotopias of the Head and neck from our institute is presented in this study. Materials and methods: This study is conducted in a tertiary care center for Head and neck diseases. The Heterotopic lesions occurring in head and neck reported between 2008 and 2016 were included in the study. 24 cases of Head and neck heterotopias were identified. Clinical findings, radiological, cytological and histopathological aspects were analysed. Results: Heterotopias constituted 0.17% of all head and neck lesions. A total of 24 cases of heterotopias were analysed. Thyroid heterotopias constituted majority, 13 cases (54.16%). There were 5 cases of Glial heterotopias (20.83%), 3 Salivary gland heterotopias (12.5%), 2 gastric heterotopias (8.33%) (one single tissue type and ...
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Nettime-ro] \\ aphanitik singularity Nettime-ro] \\ aphanitik singularity
Aphanitic Singularity [abstrakt Alisa Andrasek + Netochka Nezvanova All possible branches are real (Borges, J.L. The Garden of Forking Paths) Gardens were always optimistic reflections of the world, the liminal spaces between the known and unknown, matter and aether. Foucault describes gardens as the oldest form of heterotopias, a microcosm of species, the smallest parcel of the world in its totality: The heterotopia is capable of juxtaposing in a single real place several spaces, several sites that are in themselves incompatible ... the oldest example of these heterotopias that take the form of contradictory sites is the garden. Shifting away from millennia old, rigid and static instrumentalities of control on the one side and fictional representational effects on the other, this paper discusses genware, a computational system employing dynamically relational assemblages for analysis, synthesis and cataloguing of regional folkloric and cultural artifacts phenotypes into a library of ...
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Gray matter heterotopiaGray matter heterotopia
Gray matter heterotopia Grey Matter Heterotopia (singular heterotopion)[1] is a neurological disorder caused by clumps of grey matter being located in the
https://www.bionity.com/en/encyclopedia/Gray_matter_heterotopia.html
Lissencephaly | Definition of Lissencephaly by Merriam-WebsterLissencephaly | Definition of Lissencephaly by Merriam-Webster
Define lissencephaly: the condition of having a smooth appearance on the surface of the brain; specifically : an abnormality of brain development…
https://www.merriam-webster.com/dictionary/lissencephaly
Face hitting steering wheel. Have seizure like spells, not able to focus. MRI shows heterotopia. Can these be treated with...Face hitting steering wheel. Have seizure like spells, not able to focus. MRI shows heterotopia. Can these be treated with...
Question - Face hitting steering wheel. Have seizure like spells, not able to focus. MRI shows heterotopia. Can these be treated with medicine?. Ask a Doctor about when and why MRI is advised, Ask a Neurologist
http://www.healthcaremagic.com/questions/Face-hitting-steering-wheel-Have-seizure-like-spells-not-able-to-focus-MRI-shows-heterotopia-Can-these-be-treated-with-medicine/283082
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Nasal glial heterotopia - WikipediaNasal glial heterotopia - Wikipedia
Nasal glial heterotopia refers to congenital malformations of displaced normal, mature glial tissue, which are no longer in continuity with an intracranial component. This is distinctly different from an encephalocele, which is a herniation of brain tissue and/or leptomeninges, that develops through a defect in the skull, where there is a continuity with the cranial cavity. While nasal glial heterotopia (NGH) is the preferred term, synonyms have included nasal glioma. However, this term is to be discouraged, as it implies a neoplasm or tumor, which it is not. By definition, nasal glial heterotopia is a specific type of choristoma. It is not a teratoma, however, which is a neoplasm comprising all three germ cell layers (ectoderm, endoderm, mesoderm). As a congenital malformation or ectopia, it is distinctly different from the trauma or iatrogenic development of an encephalocele. Patients come to clinical attention early in life (usually at birth or within the first few months), with a firm ...
https://en.wikipedia.org/wiki/Nasal_glial_heterotopia
Controlled Study of Rigosertib Versus Physicians Choice of Treatment in MDS Patients After Failure of an HMA | Clinical...Controlled Study of Rigosertib Versus Physicians Choice of Treatment in MDS Patients After Failure of an HMA | Clinical...
Clinical trial for MYELODYSPLASTIC SYNDROME | Preleukemia | Refractory Anemia with Excess of Blasts | miller-dieker syndrome , Controlled Study of Rigosertib Versus Physicians Choice of Treatment in MDS Patients After Failure of an HMA
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Lissencephaly | definition of lissencephaly by Medical dictionaryLissencephaly | definition of lissencephaly by Medical dictionary
Looking for online definition of lissencephaly in the Medical Dictionary? lissencephaly explanation free. What is lissencephaly? Meaning of lissencephaly medical term. What does lissencephaly mean?
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Age-related clinical and neurophysiologic characteristics of intractable epilepsy associated with cortical malformation<...Age-related clinical and neurophysiologic characteristics of intractable epilepsy associated with cortical malformation<...
TY - JOUR. T1 - Age-related clinical and neurophysiologic characteristics of intractable epilepsy associated with cortical malformation. AU - Kobayashi, Katsuhiro. AU - Ohtsuka, Y.. AU - Ohno, S.. AU - Tanaka, A.. AU - Hiraki, Y.. AU - Oka, E.. PY - 2001. Y1 - 2001. N2 - Purpose: To elucidate the relationship between the characteristics of cortical malformation (CM) and those of associated epilepsy, and also to investigate the prognostic value of the clinical and magnetic resonance imaging (MRI) findings for the seizure and mental outcome. Methods: We studied 41 patients with CM and epilepsy, and the patients were divided according to the age at onset of epilepsy into two groups: one group of 15 patients with very early onset before age 3 months, and the other group of 26 patients with onset at 3 months or later. Statistical relationship was examined between the types of dysplastic lesions demonstrated by MRI and the age at onset of epilepsy. The effects of the onset age and the features of CM ...
https://okayama.pure.elsevier.com/en/publications/age-related-clinical-and-neurophysiologic-characteristics-of-intr
Stem Cell Discovery Illuminates Brain Evolution, Points To Therapies - RedorbitStem Cell Discovery Illuminates Brain Evolution, Points To Therapies - Redorbit
UCSF scientists have discovered a new stem cell in the developing human brain. The cell produces nerve cells that help form the neocortex the site of higher cognitive functionand likely accounts for the dramatic expansion of the region in the lineages that lead to man, the researchers say. Future studies of these cells are expected to shed light on developmental diseases such as autism and schizophrenia and malformations of brain development, including microcephaly, lissencephaly and neuronal migration disorders, they say, as well as age-related illnesses, such as Alzheimers disease.. Studies also will allow scientists to track the molecular steps that the cell goes through as it evolves into the nerve cell, or neuron, it produces. This information could then be used to prompt embryonic stem cells to differentiate in the culture dish into neurons for potential use in cell-replacement therapy.. The study is reported in a recent issue of the journal Nature, (vol. no. 464, 554-561; issue ...
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HETEROTOPIAS AND CORTICAL DYSPLASIA - Neurology - MedHelpHETEROTOPIAS AND CORTICAL DYSPLASIA - Neurology - MedHelp
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Amber Kinetics + HECO Install & Test Flywheel Technology In Hawaii | CleanTechnicaAmber Kinetics + HECO Install & Test Flywheel Technology In Hawaii | CleanTechnica
Ambers innovative 8-kilowatt, 32-kilowatt hour system is capable of charging and discharging electricity for multiple duty cycles per day with no loss of capacity over a 20-year-plus service life.. As of January 2017, Hawaii was getting more than 26 percent of its electricity from renewable energy, the majority of which is distributed solar and wind. Energy storage is essential to reach our 100-percent renewable energy goals by taking advantage of Hawaiis abundant but variable solar and wind energy, said Colton Ching, Hawaiian Electric senior vice president for planning and technology. We are very enthusiastic to work with Amber Kinetics to evaluate this very promising flywheel energy storage system.. Amber Kinetics flywheel energy storage systems offer substantial benefits for a wide range of utility and commercial applications. The firms breakthrough technology extends the duration and efficiency of flywheels from minutes to hours, resulting in safe, economical and reliable energy ...
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Clinical impact of duodenal pancreatic heterotopia - Is there a need for surgical treatment? | BMC Surgery | Full TextClinical impact of duodenal pancreatic heterotopia - Is there a need for surgical treatment? | BMC Surgery | Full Text
Pancreatic heterotopia (PH) is defined as ectopic pancreatic tissue outside the normal pancreas and its vasculature and duct system. Most frequently, PH is detected incidentally by histopathological examination. The aim of the present study was to analyze a large single-center series of duodenal PH with respect to the clinical presentation. A prospective pancreatic database was retrospectively analyzed for cases of PH of the duodenum. All pancreatic and duodenal resections performed between January 2000 and October 2015 were included and screened for histopathologically proven duodenal PH. PH was classified according to Heinrichs classification (Type I acini, ducts, and islet cells; Type II acini and ducts; Type III only ducts). A total of 1274 pancreatic and duodenal resections were performed within the study period, and 67 cases of PH (5.3%) were identified. The respective patients were predominantly male (72%) and either underwent pancreatoduodenectomy (n = 60); a limited pancreas resection with
https://bmcsurg.biomedcentral.com/articles/10.1186/s12893-017-0250-x
Olennka : 30x30 brand new issue by ILSOlennka : 30x30 brand new issue by ILS
Yes, yes!! Already there is a new e-magazine 30x30 made by ILS in winter and holiday mood. Its marvelous, unearthly, beautiful, full of great inspiration, a true masterpiece. Amazing dose of Christmas ideas, beautiful images, wonderful LOs and incredibley minialbum made by Nulka. Thats all you can find in the latest edition 30x30 prepared by ILS. I urge you to read it at least a few times, so Im doing, every time something else catches my attention ...
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Gray matter heterotopia, Epileptic seizures - Online Doctor ChatsGray matter heterotopia, Epileptic seizures - Online Doctor Chats
Online Doctor Chat - Gray matter heterotopia, Epileptic seizures, Ask a Doctor about diagnosis, treatment and medication for Epileptic seizure, Online doctor patient chat conversation by Dr. Yogesh D
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Gyrus - WikipediaGyrus - Wikipedia
Changes in the structure of gyri in the cerebral cortex are associated with various diseases and disorders. Pachygyria, lissencephaly, and polymicrogyria are all the results of abnormal cell migration associated with a disorganized cellular architecture, failure to form six layers of cortical neurons (a four-layer cortex is common), and functional problems.[6] The abnormal formation is commonly associated with epilepsy and mental dysfunctions.[7]. Pachygyria (meaning thick or fat gyri) is a congenital malformation of the cerebral hemisphere, resulting in unusually thick gyri in the cerebral cortex.[8] Pachygyria is used to describe brain characteristics in association with several neuronal migration disorders; most commonly relating to lissencephaly. Lissencephaly (smooth brain) is a rare congenital brain malformation caused by defective neuronal migration during the 12th to 24th weeks of fetal gestation resulting in a lack of development of gyri and sulci.[9]. Polymicrogyria (meaning many ...
https://en.m.wikipedia.org/wiki/Gyrus
Pancreatic heterotopia as a cause of dyspepsia | GutPancreatic heterotopia as a cause of dyspepsia | Gut
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Publications | Max Planck Institute for Biophysical ChemistryPublications | Max Planck Institute for Biophysical Chemistry
Reiner, O.; Albrecht, U.; Gordon, M.; Chianese, K. A.; Wong, C.; Gal-Gerber, O.; Sapir, T.; Siracusa, L. D.; Buchberg, A. M.; Caskey, C. T. et al.; Eichele, G.: Lissencephaly gene (LIS1) expression in the CNS suggests a role in neuronal migration. The Journal of Neuroscience 15 (5), pp. 3730 - 3738 (1995 ...
https://www.mpibpc.mpg.de/publication-search/102172?page=5&person=%2Fpersons%2Fresource%2Fpersons15030
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19 Displaced Muscles (Pulley Heterotopias) | Ento Key19 Displaced Muscles (Pulley Heterotopias) | Ento Key
Yair Morad and Irene H. Ludwig Summary Acquired and congenital displacements of the paths of the eye muscles (pulley shifts and pulley heterotopias) are newly recognized causes of strabismus. Downward displacement of the lateral rectus muscles causes acquired esotropias including the
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Posted: July 2, 2013 12:00 am ET | Last Updated: July 2, 2013 11:18 pm ET | Read about the reaction to the July 2013 Proton-M rocket failure by International Launch Services (ILS), which markets Proton to commercial customers.
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DiseasesChemicals and Drugs
Classical Lissencephalies and Subcortical Band HeterotopiasLissencephalyNeuronal Migration DisordersCobblestone LissencephalyNeuropeptidesChoristomaPeriventricular Nodular HeterotopiaNervous System Malformations
Mutations in the Heterotopia Gene Eml1/EML1 Severely Disrupt the Formation of Primary CiliaMutations in the Heterotopia Gene Eml1/EML1 Severely Disrupt the Formation of Primary Cilia
Perturbing their function leads to cortical malformations, including subcortical heterotopia (SH), characterized by the ... Classical Lissencephalies and Subcortical Band Heterotopias / genetics* * Classical Lissencephalies and Subcortical Band ... Perturbing their function leads to cortical malformations, including subcortical heterotopia (SH), characterized by the ... Mutations in the Heterotopia Gene Eml1/EML1 Severely Disrupt the Formation of Primary Cilia Cell Rep. 2019 Aug 6;28(6):1596- ...
https://pubmed.ncbi.nlm.nih.gov/31390572/
Pyruvate Dehydrogenase Complex Deficiency Disease | Profiles RNSPyruvate Dehydrogenase Complex Deficiency Disease | Profiles RNS
Classical Lissencephalies and Subcortical Band Heterotopias. *Coffin-Lowry Syndrome. *Fragile X Syndrome ...
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DiseasesChemicals and Drugs
Classical Lissencephalies and Subcortical Band HeterotopiasLissencephalyNeuronal Migration DisordersCobblestone LissencephalyNeuropeptidesChoristomaPeriventricular Nodular HeterotopiaNervous System Malformations
LissencephalyPolymicrogyria and subcortical heterotopiaPachygyriaLaminarMutationsDiagnosisSevere
Lissencephaly7
  • Subcortical band heterotopia (SBH) are bilateral and symmetric ribbons of gray matter found in the central white matter between the cortex and the ventricular surface, which comprises the less severe end of the lissencephaly (agyria-pachygyria-band) spectrum of malformations. (elsevier.com)
  • Lissencephaly spectrum (LIS) is one of the most severe neuronal migration disorders that ranges from agyria/pachygyria to subcortical band heterotopia. (cdc.gov)
  • Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, cognitive disability, subcortical band heterotopia ('double cortex' syndrome) in females and lissencephaly ('smooth brain' syndrome) in males. (nih.gov)
  • To estimate diagnostic yield and genotype-phenotype correlations in a cohort of 811 patients with lissencephaly or subcortical band heterotopia. (mendelian.org)
  • two large groups can be distinguished: classical lissencephaly (and its variants) and cobblestone lissencephaly. (malacards.org)
  • in classical lissencephaly (or type i), the cortex appears thickened, with four more or less disorganised layers rather than six normal layers. (malacards.org)
  • in the variants of classical lissencephaly, extra-cortical anomalies are also present (total or subtotal agenesis of the corpus callosum and/or cerebellar hypoplasia). (malacards.org)
Polymicrogyria and subcortical heterotopia1
  • A neonate presented hypotonia, increased serum creatine kinase levels, and polymicrogyria and subcortical heterotopia on brain MRI involving both posterior temporal and occipital lobes. (bvsalud.org)
Pachygyria1
  • The majority of unsolved patients had posterior pachygyria, subcortical band heterotopia, or mild frontal pachygyria. (mendelian.org)
Laminar1
  • Other mechanisms which may lead to PMG include premature folding of the neuronal band, abnormal fusion of adjacent gyri and laminar necrosis of the developing cortex. (biomedcentral.com)
Mutations1
  • Ledbetter, David H. / Subcortical band heterotopia in rare affected males can be caused by missense mutations in DCX(XLIS) or LIS1 . (elsevier.com)
Diagnosis1
  • To investigate the prenatal ultrasonic manifestations of fetal gray matter heterotopias (FGMH) and evaluate the optimal method its prenatal diagnosis. (bvsalud.org)
Severe1
  • in addition to these four entities, isolated lissencephalies without a known genetic defect, lissencephalies with severe microcephaly (microlissencephaly) and lissencephalies associated with polymalformative syndromes are also included in the group of classical lissencephalies. (malacards.org)