Class Ia Phosphatidylinositol 3-Kinase

Phosphatidylinositol 3-Kinases

P110δ

Phosphoinositide 3-kinase

USP8

Erythropoietin receptor

Insulin

HEAT repeat

KIF1A

Platelet-derived growth factor receptor

N-Acylethanolamine

Nicotinic acid adenine dinucleotide phosphate

Regulatory Subunit1

• A phosphatidylinositol 3-kinase subclass that includes enzymes formed through the heterodimerization of a p110 catalytic and a p85, p55, or p50 regulatory subunit. (bvsalud.org)

PROTEIN6

• This subclass of enzymes is a downstream target of TYROSINE KINASE RECEPTORS and G PROTEIN -COUPLED RECEPTORS. (bvsalud.org)
• Exposure to asphalt fumes activates activator protein-1 through the phosphatidylinositol 3-Kinase/Akt signaling pathway in mouse epidermal cells. (cdc.gov)
• cJun is regulated by the NPM-ALK tyrosine kinase via pathologic phosphorylation and subsequent activation of cJun N-terminal kinase (JNK), the protein kinase capable of phosphorylating serine residues in the N-terminal of cJun and effecting its subsequent activation [ 13 ]. (biomedcentral.com)
• JNK is only physiologically phosphorylated by the mitogen activated protein kinase (MAPK) kinases MKK4 and MKK7. (biomedcentral.com)
• Click on the protein counts, or double click on taxonomic names to display all proteins containing Int_alpha domain in the selected taxonomic class. (embl.de)
• Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. (lookformedical.com)

Insulin2

• Anaplastic lymphoma kinase 1 (ALK-1) is a member of the insulin receptor tyrosine kinase family. (biomedcentral.com)
• Diabetes mellitus is characterized by chronic hyperglycemia, which is resulted from the loss of β cell mass or loss of insulin sensitivity [ 1 - 3 ]. (oncotarget.com)

Note1

• He has published on both the scientific bases of human health risk assessment and its application to risk policy with a focus on risk/risk tradeoffs in risk management George teaches toxicology and risk assessment at the Harvard School of Public Health to both graduate students and participants in the School's Continuing Professional Education program" his biographical note states. (sourcewatch.org)

Complex1

• Bellus et al, 1995a) Hypochondroplasia( HCH) takes a milder system complex that is the recruitment of classes in the gradient loop transcription of FGFR3( Bellus et al, 1995b). (familie-vos.de)

Stage1

• Early-stage cervical cancer is a potentially curable disease either by surgery (for those diagnosed with International Federation of Gynecology and Obstetrics (FIGO) stage IA/B1 disease) or by a combination of low dose chemotherapy administered concurrently with radiotherapy followed by intracavitary brachytherapy. (biomedcentral.com)

Phosphoinositide 3-kina4

• 1. The Phosphoinositide 3-Kinase p110α Isoform Regulates Leukemia Inhibitory Factor Receptor Expression via c-Myc and miR-125b to Promote Cell Proliferation in Medulloblastoma. (nih.gov)
• 6. Selective inhibition of phosphoinositide 3-kinase p110α preserves lymphocyte function. (nih.gov)
• 7. Targeting the phosphoinositide 3-kinase p110-α isoform impairs cell proliferation, survival, and tumor growth in small cell lung cancer. (nih.gov)
• 9. Targeting the phosphoinositide 3-kinase isoform p110delta impairs growth and survival in neuroblastoma cells. (nih.gov)

PI3K6

• The phosphatidylinositol 3 kinase (PI3K) pathway regulates fundamental cellular processes such as metabolism, proliferation, and survival. (nih.gov)
• 11. Targeting class IA PI3K isoforms selectively impairs cell growth, survival, and migration in glioblastoma. (nih.gov)
• An abundance of data suggests that genetic aberrations and activation of the phosphatidylinositol 3-kinase (PI3K) pathway are important in determining breast cancer prognosis and the efficacy of standard chemo- and endocrine therapies. (medscape.com)
• [ 3 ] Furthermore, mutations in the PIK3CA gene, which encodes the p110α catalytic subunit of the class IA PI3K, are frequent in breast cancer. (medscape.com)
• The PIK3R1 gene provides instructions for making a part (subunit) of an enzyme called phosphatidylinositol 3-kinase (PI3K). (medlineplus.gov)
• PI3K is a kinase, which means that it adds a cluster of oxygen and phosphorus atoms (a phosphate group) to other proteins through a process called phosphorylation. (medlineplus.gov)

Pathway1

• Exposure to asphalt fumes activates activator protein-1 through the phosphatidylinositol 3-Kinase/Akt signaling pathway in mouse epidermal cells. (cdc.gov)

Gene2

• Finding a gain-of-function mutation in phosphatidylinositol 3-kinase gene explained why PASLI disease individuals were unable to appropriately activate T cell responses to recurrent viral infections and simultaneously suffer from lymphoproliferation. (nih.gov)
• PMID- 9228551 DA - 19971120 DCOM- 19971120 LR - 20031114 IS - 0162-3109 VI - 36 IP - 2-3 DP - 1997 Jun TI - Kallikrein gene therapy: a new strategy for hypertensive diseases. (nih.gov)

Downstream2

• Neither iAs III nor MAs III interfered with the phosphorylation of 3-phosphoinositide-dependent kinase-1 (PDK-1) located downstream from PI-3K. (nih.gov)
• This subclass of enzymes is a downstream target of TYROSINE KINASE RECEPTORS and G PROTEIN-COUPLED RECEPTORS . (nih.gov)

Protein2

• 14. Role of protein arginine methyltransferase 5 in group 3 (MYC-driven) Medulloblastoma. (nih.gov)
• We have previously shown that trivalent metabolites of iAs, arsenite (iAs III ) and methylarsonous acid (MAs III ) inhibit insulin-stimulated glucose uptake (ISGU) in 3T3-L1 adipocytes by suppressing the insulin-dependent phosphorylation of protein kinase B (PKB/Akt). (nih.gov)

20211

• 2021. Calcium-Prolactin Secretion Coupling in Rat Pituitary Lactotrophs Is Controlled by PI4-Kinase Alpha. (nih.gov)

Effect2

• PIK3CA mutations were associated with a better outcome, however this effect disappeared after 3 years. (medscape.com)
• Subtoxic concentrations of iAs III or MAs III had little or no effect on the activity of phosphatidylinositol 3-kinase (PI-3K), which synthesizes phosphatidylinositol-3,4,5-triphosphate (PIP 3 ), or on phosphorylation of PTEN (phosphatase and tensin homolog deleted on chromosome ten), a PIP 3 phosphatase. (nih.gov)

University1

• He performed clinical work in internal medicine and research at the University of Iowa. (nih.gov)