Clarithromycin: A semisynthetic macrolide antibiotic derived from ERYTHROMYCIN that is active against a variety of microorganisms. It can inhibit PROTEIN SYNTHESIS in BACTERIA by reversibly binding to the 50S ribosomal subunits. This inhibits the translocation of aminoacyl transfer-RNA and prevents peptide chain elongation.Anti-Bacterial Agents: Substances that reduce the growth or reproduction of BACTERIA.Amoxicillin: A broad-spectrum semisynthetic antibiotic similar to AMPICILLIN except that its resistance to gastric acid permits higher serum levels with oral administration.Azithromycin: A semi-synthetic macrolide antibiotic structurally related to ERYTHROMYCIN. It has been used in the treatment of Mycobacterium avium intracellulare infections, toxoplasmosis, and cryptosporidiosis.Helicobacter pylori: A spiral bacterium active as a human gastric pathogen. It is a gram-negative, urease-positive, curved or slightly spiral organism initially isolated in 1982 from patients with lesions of gastritis or peptic ulcers in Western Australia. Helicobacter pylori was originally classified in the genus CAMPYLOBACTER, but RNA sequencing, cellular fatty acid profiles, growth patterns, and other taxonomic characteristics indicate that the micro-organism should be included in the genus HELICOBACTER. It has been officially transferred to Helicobacter gen. nov. (see Int J Syst Bacteriol 1989 Oct;39(4):297-405).Helicobacter Infections: Infections with organisms of the genus HELICOBACTER, particularly, in humans, HELICOBACTER PYLORI. The clinical manifestations are focused in the stomach, usually the gastric mucosa and antrum, and the upper duodenum. This infection plays a major role in the pathogenesis of type B gastritis and peptic ulcer disease.Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS. It has also been proposed as a radiation sensitizer for hypoxic cells. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985, p133), this substance may reasonably be anticipated to be a carcinogen (Merck, 11th ed).Biological Products: Complex pharmaceutical substances, preparations, or matter derived from organisms usually obtained by biological methods or assay.Materia Medica: Materials or substances used in the composition of traditional medical remedies. The use of this term in MeSH was formerly restricted to historical articles or those concerned with traditional medicine, but it can also refer to homeopathic remedies. Nosodes are specific types of homeopathic remedies prepared from causal agents or disease products.Health Food: A non-medical term defined by the lay public as a food that has little or no preservatives, which has not undergone major processing, enrichment or refinement and which may be grown without pesticides. (from Segen, The Dictionary of Modern Medicine, 1992)Herb-Drug Interactions: The effect of herbs, other PLANTS, or PLANT EXTRACTS on the activity, metabolism, or toxicity of drugs.Consumer Product SafetyStomach Ulcer: Ulceration of the GASTRIC MUCOSA due to contact with GASTRIC JUICE. It is often associated with HELICOBACTER PYLORI infection or consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).Library Services: Services offered to the library user. They include reference and circulation.Libraries, MedicalPesticides: Chemicals used to destroy pests of any sort. The concept includes fungicides (FUNGICIDES, INDUSTRIAL); INSECTICIDES; RODENTICIDES; etc.North AmericaInternet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Pesticide Residues: Pesticides or their breakdown products remaining in the environment following their normal use or accidental contamination.Tablets, Enteric-Coated: Tablets coated with material that delays release of the medication until after they leave the stomach. (Dorland, 28th ed)Drugs, Generic: Drugs whose drug name is not protected by a trademark. They may be manufactured by several companies.Tablets: Solid dosage forms, of varying weight, size, and shape, which may be molded or compressed, and which contain a medicinal substance in pure or diluted form. (Dorland, 28th ed)Therapeutic Equivalency: The relative equivalency in the efficacy of different modes of treatment of a disease, most often used to compare the efficacy of different pharmaceuticals to treat a given disease.Delayed-Action Preparations: Dosage forms of a drug that act over a period of time by controlled-release processes or technology.IndiaDeductibles and Coinsurance: Cost-sharing mechanisms that provide for payment by the insured of some portion of covered expenses. Deductibles are the amounts paid by the insured under a health insurance contract before benefits become payable; coinsurance is the provision under which the insured pays part of the medical bill, usually according to a fixed percentage, when benefits become payable.Sotalol: An adrenergic beta-antagonist that is used in the treatment of life-threatening arrhythmias.Amiodarone: An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM CHANNELS. There is a resulting decrease in heart rate and in vascular resistance.Long QT Syndrome: A condition that is characterized by episodes of fainting (SYNCOPE) and varying degree of ventricular arrhythmia as indicated by the prolonged QT interval. The inherited forms are caused by mutation of genes encoding cardiac ion channel proteins. The two major forms are ROMANO-WARD SYNDROME and JERVELL-LANGE NIELSEN SYNDROME.Torsades de Pointes: A malignant form of polymorphic ventricular tachycardia that is characterized by HEART RATE between 200 and 250 beats per minute, and QRS complexes with changing amplitude and twisting of the points. The term also describes the syndrome of tachycardia with prolonged ventricular repolarization, long QT intervals exceeding 500 milliseconds or BRADYCARDIA. Torsades de pointes may be self-limited or may progress to VENTRICULAR FIBRILLATION.Erythromycin: A bacteriostatic antibiotic macrolide produced by Streptomyces erythreus. Erythromycin A is considered its major active component. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.Australia: The smallest continent and an independent country, comprising six states and two territories. Its capital is Canberra.TextilesInsurance, Pharmaceutical Services: Insurance providing for payment of services rendered by the pharmacist. Services include the preparation and distribution of medical products.Chemistry, Organic: The study of the structure, preparation, properties, and reactions of carbon compounds. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Chemistry, Clinical: The specialty of ANALYTIC CHEMISTRY applied to assays of physiologically important substances found in blood, urine, tissues, and other biological fluids for the purpose of aiding the physician in making a diagnosis or following therapy.Abbreviations as Topic: Shortened forms of written words or phrases used for brevity.Lymphedema: Edema due to obstruction of lymph vessels or disorders of the lymph nodes.Lymphoma, B-Cell, Marginal Zone: Extranodal lymphoma of lymphoid tissue associated with mucosa that is in contact with exogenous antigens. Many of the sites of these lymphomas, such as the stomach, salivary gland, and thyroid, are normally devoid of lymphoid tissue. They acquire mucosa-associated lymphoid tissue (MALT) type as a result of an immunologically mediated disorder.Omeprazole: A 4-methoxy-3,5-dimethylpyridyl, 5-methoxybenzimidazole derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits an H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.Drug Costs: The amount that a health care institution or organization pays for its drugs. It is one component of the final price that is charged to the consumer (FEES, PHARMACEUTICAL or PRESCRIPTION FEES).Click Chemistry: Organic chemistry methodology that mimics the modular nature of various biosynthetic processes. It uses highly reliable and selective reactions designed to "click" i.e., rapidly join small modular units together in high yield, without offensive byproducts. In combination with COMBINATORIAL CHEMISTRY TECHNIQUES, it is used for the synthesis of new compounds and combinatorial libraries.Copyright: It is a form of protection provided by law. In the United States this protection is granted to authors of original works of authorship, including literary, dramatic, musical, artistic, and certain other intellectual works. This protection is available to both published and unpublished works. (from Circular of the United States Copyright Office, 6/30/2008)Digoxin: A cardiotonic glycoside obtained mainly from Digitalis lanata; it consists of three sugars and the aglycone DIGOXIGENIN. Digoxin has positive inotropic and negative chronotropic activity. It is used to control ventricular rate in ATRIAL FIBRILLATION and in the management of congestive heart failure with atrial fibrillation. Its use in congestive heart failure and sinus rhythm is less certain. The margin between toxic and therapeutic doses is small. (From Martindale, The Extra Pharmacopoeia, 30th ed, p666)Emergency Medicine: The branch of medicine concerned with the evaluation and initial treatment of urgent and emergent medical problems, such as those caused by accidents, trauma, sudden illness, poisoning, or disasters. Emergency medical care can be provided at the hospital or at sites outside the medical facility.Poisoning: A condition or physical state produced by the ingestion, injection, inhalation of or exposure to a deleterious agent.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Publishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.Equipment Contamination: The presence of an infectious agent on instruments, prostheses, or other inanimate articles.Drug Prescriptions: Directions written for the obtaining and use of DRUGS.Prescriptions: Directions written for the obtaining and use of PHARMACEUTICAL PREPARATIONS; MEDICAL DEVICES; corrective LENSES; and a variety of other medical remedies.Prescription Drugs: Drugs that cannot be sold legally without a prescription.Pharmaceutical Services, Online: Pharmacy services accessed via electronic means.

Successful short-term suppression of clarithromycin-resistant Mycobacterium avium complex bacteremia in AIDS. California Collaborative Treatment Group. (1/1145)

During a randomized study of clarithromycin plus clofazimine with or without ethambutol in patients with AIDS and Mycobacterium avium complex (MAC) bacteremia, eight participants received additional antimycobacterial drugs following the detection of a clarithromycin-resistant isolate (MIC, > 8 micrograms/mL). A macrolide (seven received clarithromycin, one azithromycin) and clofazimine were continued; additional treatment included various combinations of ethambutol, ciprofloxacin, amikacin, and rifabutin. After the detection of a resistant isolate and before receipt of additional antimycobacterials, the median peak MAC colony count in blood was 105 cfu/mL (range, 8-81,500 cfu/mL). After additional antimycobacterials, the median nadir MAC colony count was 5 cfu/mL (range, 0-110 cfu/mL). Five (63%) of eight patients had a > or = 1 log10 decrease, including two who achieved negative blood cultures; all of these responses occurred in patients originally assigned to clarithromycin plus clofazimine. Treatment of clarithromycin-resistant MAC bacteremia that emerges during clarithromycin-based treatment can decrease levels of bacteremia and transiently sterilize blood cultures.  (+info)

Multiplex sequence analysis demonstrates the competitive growth advantage of the A-to-G mutants of clarithromycin-resistant Helicobacter pylori. (2/1145)

Clarithromycin resistance in Helicobacter pylori is due to point mutation within the 23S rRNA. We examined the growth rates of different types of site-directed mutants and demonstrated quantitatively the competitive growth advantage of A-to-G mutants over other types of mutants by a multiplex sequencing assay. The results provide a rational explanation of why A-to-G mutants are predominantly observed among clarithromycin-resistant clinical isolates.  (+info)

Direct detection of Helicobacter pylori resistance to macrolides by a polymerase chain reaction/DNA enzyme immunoassay in gastric biopsy specimens. (3/1145)

BACKGROUND: The increasing use of macrolides especially in the treatment of Helicobacter pylori infection has led to an increase in resistant strains. The resistance of H pylori to macrolides, especially clarithromycin, is one of the major causes of eradication failure. In H pylori, clarithromycin resistance is due to point mutations localised in domain V of 23S rRNA. AIM: To develop a molecular technique based on amplification of a relevant fragment of the 23S rRNA and colorimetric hybridisation in liquid phase to detect directly in biopsy specimens the type of mutation associated with resistance of H pylori to clarithromycin. METHODS: Gastric biopsy samples from 61 patients were submitted to this test. The results were compared with standard methods (determination of minimal inhibition concentration, polymerase chain reaction/restriction fragment length polymorphism, and/or DNA sequencing) in order to evaluate the test and to define the cut off values, specificity, and sensitivity. RESULTS: The 14 biopsy samples in which H pylori was not detected did not give a positive result in any assay, and the 14 samples harbouring strains susceptible to clarithromycin gave a positive result with the wild type probe as expected. The 33 biopsy specimens containing resistant strains always gave a positive signal with one of the probes detecting resistant organisms, but in eight cases they also reacted with the wild type probe, indicating that a mixture of resistant and susceptible organisms was present. CONCLUSION: The importance of this new assay is that it allows the detection of multiple genotypes corresponding to either heterogeneous genotypes or mixed infections. Moreover, it allows in a single step not only the detection of H pylori but also the determination of its susceptibility to clarithromycin directly in biopsy specimens without the need for culture.  (+info)

Eradication of Helicobacter pylori in functional dyspepsia: randomised double blind placebo controlled trial with 12 months' follow up. The Optimal Regimen Cures Helicobacter Induced Dyspepsia (ORCHID) Study Group. (4/1145)

OBJECTIVES: To determine whether eradication of Helicobacter pylori relieves the symptoms of functional dyspepsia. DESIGN: Multicentre randomised double blind placebo controlled trial. SUBJECTS: 278 patients infected with H pylori who had functional dyspepsia. SETTING: Predominantly secondary care centres in Australia, New Zealand, and Europe. INTERVENTION: Patients randomised to receive omeprazole 20 mg twice daily, amoxicillin 1000 mg twice daily, and clarithromycin 500 mg twice daily or placebo for 7 days. Patients were followed up for 12 months. MAIN OUTCOME MEASURES: Symptom status (assessed by diary cards) and presence of H pylori (assessed by gastric biopsies and 13C-urea breath testing using urea labelled with carbon-13). RESULTS: H pylori was eradicated in 113 patients (85%) in the treatment group and 6 patients (4%) in the placebo group. At 12 months follow up there was no significant difference between the proportion of patients treated successfully by intention to treat in the eradication arm (24%, 95% confidence interval 17% to 32%) and the proportion of patients treated successfully by intention to treat in the placebo group (22%, 15% to 30%). Changes in symptom scores and quality of life did not significantly differ between the treatment and placebo groups. When the groups were combined, there was a significant association between treatment success and chronic gastritis score at 12 months; 41/127 (32%) patients with no or mild gastritis were successfully treated compared with 21/123 (17%) patients with persistent gastritis (P=0. 008). CONCLUSION: No convincing evidence was found that eradication of H pylori relieves the symptoms of functional dyspepsia 12 months after treatment.  (+info)

Altered expression profile of the surface glycopeptidolipids in drug-resistant clinical isolates of Mycobacterium avium complex. (5/1145)

Members of the Mycobacterium avium complex are the most frequently encountered opportunistic bacterial pathogens among patients in the advanced stage of AIDS. Two clinical isolates of the same strain, numbers 397 and 417, were obtained from an AIDS patient with disseminated M. avium complex infection before and after treatment with a regimen of clarithromycin and ethambutol. To identify the biochemical consequence of drug treatment, the expression and chemical composition of their major cell wall constituents, the arabinogalactan, lipoarabinomannan, and the surface glycopeptidolipids (GPL), were critically examined. Through thin layer chromatography, mass spectrometry, and chemical analysis, it was found that the GPL expression profiles differ significantly in that several apolar GPLs were overexpressed in the clinically resistant 417 isolate at the expense of the serotype 1 polar GPL, which was the single predominant band in the ethambutol-susceptible 397 isolate. Thus, instead of additional rhamnosylation on the 6-deoxytalose (6-dTal) appendage to give the serotype 1-specific disaccharide hapten, the accumulation of this nonextended apolar GPL probably provided more precursor substrate available for further nonsaccharide substitutions including a higher degree of O-methylation to give 3-O-Me-6-dTal and the unusual 4-O-sulfation on 6-dTal. Further data showed that this alteration effectively neutralized ethambutol, which is known to inhibit arabinan synthesis. Thus, in contrast with derived Emb-resistant mutants of Mycobacterium smegmatis or Mycobacterium tuberculosis, which are devoid of a surface GPL layer, the lipoarabinomannan from resistant 417 isolate grown in the presence of this drug was not apparently truncated.  (+info)

Treatment of Helicobacter pylori and Chlamydia pneumoniae infections decreases fibrinogen plasma level in patients with ischemic heart disease. (6/1145)

BACKGROUND: Chronic Chlamydia pneumoniae and Helicobacter pylori infections could be a risk factor for ischemic heart disease (IHD), possibly by increasing fibrinogen levels. The aim of our study was to evaluate changes in fibrinogen level in patients with IHD and H pylori and/or C pneumoniae positivity randomly assigned to antibiotic treatment. METHODS AND RESULTS: Eighty-four patients with chronic IHD, H pylori and/or C pneumoniae antibodies, and normal acute-phase reactants were randomly assigned to treatment or no treatment. Treatment consisted of omeprazole, clarithromycin, and tinidazole in H pylori-positive patients and clarithromycin alone in C pneumoniae-positive patients. The effect of treatment and other baseline variables on fibrinogen levels, determined at 6 months, was evaluated by multivariate analysis. Treatment significantly reduced fibrinogen level at 6 months in the overall study population and in the groups of patients divided according to H pylori or C pneumoniae positivity. In the 43 treated patients, mean (+/-SD) basal fibrinogen was 3.65+/-0.58 g/L, and mean final fibrinogen was 3. 09+/-0.52 g/dL (P<0.001), whereas in the 41 untreated patients, mean basal and final fibrinogen levels were 3.45+/-0.70 and 3.61+/-0.71 g/L, respectively. The largest decrease was observed in patients with both infections. Fibrinogen changes were also significantly and negatively correlated with age. CONCLUSIONS: Our data suggest that a short, safe, and effective course of antibiotic therapy might be suggested as a means of interacting with an "emerging" risk factor.  (+info)

Ranitidine bismuth citrate, tetracycline, clarithromycin twice-a-day triple therapy for clarithromycin susceptible Helicobacter pylori infection. (7/1145)

BACKGROUND: Although many combination therapies have been proposed, there is still interest in identifying simple, inexpensive, effective protocols that have high rates of success. AIM: To investigate the role of the new soluble form of bismuth, ranitidine bismuth citrate, in twice-a-day therapy for Helicobacter pylori infection. METHODS: Patients with histologically and culture proven H. pylori infection received ranitidine bismuth citrate 400 mg, tetracycline HCl 500 mg, and clarithromycin 500 mg, each b.d. for 14 days, followed by 300 mg ranitidine once a day for 4 additional weeks. Outcome was assessed 4 or more weeks after the end of antimicrobial therapy by repeat endoscopy with histology and culture (49 patients) or urea breath testing (14 patients). RESULTS: Sixty-three patients completed the therapy, 59 men and four women (average age 56.7 years; range 31-75 years). All patients had clarithromycin-susceptible strains prior to therapy. H. pylori infection was cured in 94% (95% CI: 85-98%). There was a therapy failure in one patient who took the medicine for only 1 day and stopped because of side-effects. Three of the isolates from treatment failures were available post-failure; two were clarithromycin-resistant and one was susceptible. Side-effects were severe in two patients (3%) and moderate in three (primarily diarrhoea). CONCLUSIONS: Twice-a-day ranitidine bismuth citrate, tetracycline, clarithromycin triple therapy was well tolerated and effective for the treatment of H. pylori infection in patients with clarithromycin-susceptible H. pylori.  (+info)

The DU-MACH study: eradication of Helicobacter pylori and ulcer healing in patients with acute duodenal ulcer using omeprazole based triple therapy. (8/1145)

AIM: To investigate the efficacy of two omeprazole triple therapies for the eradication of Helicobacter pylori, ulcer healing and ulcer relapse during a 6-month treatment-free period in patients with active duodenal ulcer. METHODS: This was a double-blind, randomized study in 15 centres across Canada. Patients (n = 149) were randomized to omeprazole 20 mg once daily (O) or one of two 1-week b. d. eradication regimens: omeprazole 20 mg, metronidazole 400 mg and clarithromycin 250 mg (OMC) or omeprazole 20 mg, amoxycillin 1000 mg and clarithromycin 500 mg (OAC). All patients were treated for three additional weeks with omeprazole 20 mg once daily. Ulcer healing was assessed by endoscopy after 4 weeks of study therapy. H. pylori eradication was determined by a 13C-urea breath test and histology, performed at pre-entry, at 4 weeks after the end of all therapy and at 6 months. RESULTS: The intention-to-treat (intention-to-treat) analysis contained 146 patients and the per protocol (per protocol) analysis, 114 patients. The eradication rates were (intention-to-treat/per protocol): OMC-85% and 92%, OAC-78% and 87% and O-0% (O). Ulcer healing (intention-to-treat) was greater than 90% in all groups. The differences in the eradication and relapse rates between O vs. OMC and O vs. OAC were statistically significant (all, P < 0.001). Treatment was well tolerated and compliance was high. CONCLUSION: The OMC and OAC 1-week treatment regimens are safe and effective for eradication, healing and the prevention of relapse in duodenal ulcer patients.  (+info)

*Schedule H

... is a class of prescription drugs in India appearing as an appendix to the Drugs and Cosmetics Rules, 1945 introduced in 1945. These are drugs which cannot be purchased over the counter without the prescription of a qualified doctor.The manufacture and sale of all drugs are covered under the Drugs and Cosmetics Act and Rules. It is revised at times based on the advice of the Drugs Technical Advisory Board, part of the Central Drugs Standard Control Organization[1] in the Ministry of Health and Family Welfare. The most recent schedule H (2006) lists 536 drugs from abacavir to zuclopenthixol.[2] However, enforcement of Schedule H laws in India is lax, compared to the more restrictive Schedule X, for which a mandatory documentation trail must be maintained.[3] ...

*Macrolide

... s, mainly erythromycin and clarithromycin, also have a class effect of QT prolongation, which can lead to torsades de ... The macrolide antibiotics erythromycin, clarithromycin, and roxithromycin have proven to be an effective long-term treatment ... This is because some macrolides (clarithromycin and erythromycin, not azithromycin) are potent inhibitors of the cytochrome ... US FDA-approved : Azithromycin - unique; does not extensively inhibit CYP3A4 Clarithromycin Erythromycin Fidaxomicin ...

*Narcolepsy

These currently include clarithromycin and flumazenil. Flumazenil is the only GABAA receptor antagonist on the market as of Jan ... In a test tube model, clarithromycin (an antibiotic approved by the FDA for the treatment of infections) was found to return ... June 2013). "Clarithromycin for the Treatment of Hypersomnia: A Randomized, Double-Blind, Placebo-Controlled, Crossover Trial ... "It is important to note that the positive effect of clarithromycin is secondary to a benzodiazepine antagonist-like effect, not ...

*Simvastatin

... clarithromycin, or telithromycin; HIV protease inhibitors; the antidepressant nefazodone; the cardiovascular drug gemfibrozil; ...

*Domperidone

Macrolide antibiotics such as erythromycin and clarithromycin. Grapefruit juice. Other potent CYP3A4 inhibitors. QT-prolonging ...

*Diffuse panbronchiolitis

Clarithromycin or roxithromycin are also commonly used. The successful results of macrolides in DPB and similar lung diseases ...

*Chlamydophila pneumoniae

Simpson JL, Powell H, Boyle MJ, Scott RJ, Gibson PG (January 2008). "Clarithromycin targets neutrophilic airway inflammation in ...

*Mycobacterium mucogenicum

Susceptible to amikacin, imipenem, cefoxitin, clarithromycin and ciprofloxacin. Resistant to isoniazid and rifampin. ...

*Mycobacterium murale

Susceptible to amikacin, azithromycin, ciprofloxacin, clarithromycin and ethambutol. Resistant to isoniazid. Differential ...

*Mycobacterium avium-intracellulare infection

... clarithromycin or azithromycin. NTM infections are usually treated with a three-drug regimen of either clarithromycin or ... The treatment of choice is surgical excision of the affected lymph nodes, with antibiotic treatment (usually clarithromycin and ... Although other drugs, such as azithromycin and clarithromycin, have laboratory and clinical activity against MAC, none has been ... Every regimen should contain either azithromycin or clarithromycin; many experts prefer ethambutol as a second drug. Many ...

*Mycobacterium marinum

... clarithromycin, and ethambutol has been described. The 2014 BBC 2 program "Hive Alive 2" shows an anecdotal instance of severe ...

*Pertussis

The antibiotics erythromycin, clarithromycin, or azithromycin are typically the recommended treatment. Newer macrolides are ... Antibiotics used include erythromycin, azithromycin, clarithromycin, or trimethoprim/sulfamethoxazole. Evidence to support ...

*Buruli ulcer

Clarithromycin or moxifloxacin are sometimes used instead of streptomycin. Other treatments may include cutting out the ulcer. ... Clarithromycin or moxifloxacin are sometimes used instead of streptomycin. Treatment may also include cutting out the ulcer. ...

*Mycobacterium bohemicum

Sensitive to compounds such as prothionamide, cycloserine, clarithromycin, gentamicin, amikacin. Resistant to compounds such as ...

*Krka (company)

An important indication area also includes anti-microbial products (clarithromycin). Krka's range of products includes ...

*Ehrlichiosis (canine)

Treatment with macrolide antibiotics like clarithromycin and azithromycin is being studied. In addition, steroids may be ...

*Taisho Pharmaceutical Co.

For clarithromycin distribution outside Japan Taisho licensed Clarithromycin To Abbott Laboratories. Taisho Pharmaceutical's ... the company's most successful product to date has been the macrolide antibiotic clarithromycin. The company's branded version ...

*Mycobacterium hassiacum

Susceptible to some antibiotics, including streptomycin, ethambutol, cycloserine, ciprofloxacin and clarithromycin. Resistant ...

*Imatinib

Its use is advised against in people on strong CYP3A4 inhibitors such as clarithromycin, chloramphenicol, ketoconazole, ... The same could be true of itraconazole, clarithromycin, grapefruit juice, among others. Conversely, CYP3A4 inductors like ...

*Management of Crohn's disease

Rifabutin, clarithromycin and clofazimine are antibiotics designed to attack mycobacterium avium subsp. paratuberculosis, which ...

*Helicobacter pylori

For the treatment of clarithromycin-resistant strains of H. pylori, the use of levofloxacin as part of the therapy has been ... In areas with higher rates of clarithromycin resistance, other options are recommended. Such a therapy has revolutionized the ... However, antibiotic resistance is appearing in H. pylori; many metronidazole- and clarithromycin-resistant strains are found in ... consisting of proton pump inhibitors such as omeprazole and the antibiotics clarithromycin and amoxicillin. Variations of the ...

*Rifabutin

"Two-year combination antibiotic therapy with clarithromycin, rifabutin, and clofazimine for Crohn's disease". Gastroenterology ...

*KCNA3

Furthermore, clofazimine in combination with the antibiotics clarithromycin and rifabutin induced remission for about 2 years ... "Two-year combination antibiotic therapy with clarithromycin, rifabutin, and clofazimine for Crohn's disease". Gastroenterology ...

*Lysostaphin

Aguinaga A, Francés ML, Del Pozo JL, Alonso M, Serrera A, Lasa I, Leiva J (Jun 2011). "Lysostaphin and clarithromycin: a ... Additionally, it has been shown that lysostaphin combined with antimicrobials such as cefazolin, clarithromycin, doxycycline, ...

*Confluent and reticulated papillomatosis

Other antibiotics found useful include azithromycin, fusidic acid, clarithromycin, erythromycin, tetracycline and cefdinir. ...
Clarithromycin is a macrolide antibiotic that fights bacteria in your body. Clarithromycin Brand name Biaxin 250 and 500 mg tablets is used to treat many different types of bacterial infections affecting the skin and respiratory system. Clarithromycin is also used together with other medicines to treat stomach ulcers caused by Helicobacter pylori.. Bacterial colonisation clarithromycin of the respiratory tract is commonly described and usually thought to be of no clinical significance. The aim of this study was to examine the presence and significance of bacteria and viruses in the upper respiratory clarithromycin tract of healthcare workers (HCWs), and association biaxin pills with respiratory symptoms.. Clarithromycin. Because your baby has such small clarithromycin nasal air passages, congestion and mucus can cause trouble breathing. Most babies do not eat well when they are having trouble breathing. Use a small clarithromycin bulb and saline drops to help clear the clarithromycin air ...
Cost of clarithromycin Central nervous system: dizziness, confusion, anxiety, insomnia; nightmares. Allergic reactions: rash, anaphylactic reactions; in some cases - Stevens-Johnson syndrome. Other reactions: temporary changes in taste sensations. Contraindications for receiving clarithromycin Cost of clarithromycin severe liver failure, hepatitis (history) Klaritro Sandoz - klaritomitsin. registered in Ukraine porphyria first trimester of pregnancy co-therapy with terfenadine, cisapride, astemizole, pimozide hypersensitivity to clarithromycin and other macrolides The pharmacokinetics of clarithromycin Cost of clarithromycin Clarithromycin is metabolized by enzymes of the cytochrome CYP3A4. The absolute bioavailability of approximately 50%. With multiple dose clarithromycin metabolism character does not change, there is no accumulation. clarithromycin Interaction with other drugs ...
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Mycobacterium avium complex (MAC) is thought to be the most common disseminated bacterial opportunistic infection in AIDS, with clinical prevalence estimates ranging from 15 to 50 percent of all AIDS patients. Clarithromycin, a new macrolide antimicrobial agent, has demonstrated activity against MAC both in the laboratory and in animals. Clinical experience treating AIDS patients with clarithromycin for disseminated MAC is limited. However, early studies have indicated few adverse effects and some improvement in clinical symptoms scores and Karnofsky performance scores over placebo treated patients.. Treatment is randomly assigned so that twice as many patients receive clarithromycin at the lower dose as at an intermediate dose for 12 weeks. Once data becomes available to support dosing patients with clarithromycin at the highest dose, then treatment will be randomly assigned so that twice as many patients receive clarithromycin at the highest dose as at the intermediate dose. Sixteen patients ...
TY - JOUR. T1 - Physiologically based pharmacokinetic model of mechanism-based inhibition of CYP3A by clarithromycin. AU - Quinney, Sara. AU - Zhang, Xin. AU - Lucksiri, Aroonrut. AU - Gorski, J. Christopher. AU - Li, Lang. AU - Hall, Stephen D.. PY - 2010/2. Y1 - 2010/2. N2 - The prediction of clinical drug-drug interactions (DDIs) due to mechanism-based inhibitors of CYP3A is complicated when the inhibitor itself is metabolized by CYP3A, as in the case of clarithromycin. Previous attempts to predict the effects of clarithromycin on CYP3A substrates, e.g., midazolam, failed to account for nonlinear metabolism of clarithromycin. A semiphysiologically based pharmacokinetic model was developed for clarithromycin and midazolam metabolism, incorporating hepatic and intestinal metabolism by CYP3A and non-CYP3A mechanisms. CYP3A inactivation by clarithromycin occurred at both sites.KI and kinact values for clarithromycin obtained from in vitro sources were unable to accurately predict the clinical ...
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Product Name: Clarithromycin Tablets Common Name: Binoclar, Bioclar, Truclar, Crixan, Claritt, Clarac, Biaxin. Strength: 500 mg. Description:. Clarithromycin is a macrolide antibiotic. It fights bacteria in your body.. Clarithromycin, is an antibiotic used to treat various bacterial infections. This includes strep throat, pneumonia, skin infections, H. pylori infection, and Lyme disease, among others. Clarithromycin can be taken by mouth as a pill or liquid.. Common side effects include nausea, vomiting, headaches, and diarrhea. Severe allergic reactions are rare. Liver problems have been reported. It may cause harm if taken during pregnancy. It is in the macrolide class and works by stopping the making of protein by some bacteria.. Clarithromycin Tablets is made from erythromycin and is chemically known as 6-O-methylerythromycin.. Indications and Usage:. Clarithromycin is an antibiotic useful for the treatment of a number of bacterial infections. It is amacrolide antibiotic used particularly ...
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1. Omeclamox®-Pak complete prescribing information. 03/2017. * Three U.S., randomized, double-blind clinical studies in patients with H. pylori infection and duodenal ulcer disease (n = 558) compared omeprazole plus clarithromycin plus amoxicillin with clarithromycin plus amoxicillin. Two studies (1 and 2) were conducted in patients with an active duodenal ulcer, and the other study (3) was conducted in patients with a history of a duodenal ulcer in the past 5 years but without an ulcer present at the time of enrollment. The combination of omeprazole plus clarithromycin plus amoxicillin was effective in eradicating H. pylori.. ...
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Main / General OTC / Clarithromycin patent expiration Join the 23, others who get our Drug Patent Expiration Alerts:. The serum concentration of Difluprednate can be increased when it is combined with Clarithromycin. Upgrade to enjoy subscriber-only features like email alerts and data export. Purification of crude clarithromycin has been reported to convert one form of clarithromycin to another form. Macrolides, ketolides, and glycylcyclines: The therapeutic efficacy of Clarithromycin can be decreased when used in combination with Cholesterol. ...
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The in-vitro susceptibility of Mycoplasma pneumoniae to clarithromycin, a new macrolide, was compared with that to erythromycin. A broth microdilution assay was used to evaluate 30 clinical isolates collected over a 15 year period from four countries (United States, Australia, Denmark and Japan). Clarithromycin inhibited the growth of all M. pneumoniae strains at low concentrations (less than or equal to 0.008 mg/l) similarly to erythromycin (less than or equal to 0.008 mg/l). In 120 outpatients with radiographically confirmed community acquired pneumonia (mean age 46.2 years), M. pneumoniae was detected culturally and/or serologically by ELISA and immunoblotting in 13% of patients, thus confirming the continued importance of this organism as a respiratory pathogen. M. pneumoniae isolates from these patients were shown to be equally susceptible to clarithromycin (less than or equal to 0.008 mg/l) and erythromycin (less than or equal to 0.008 mg/l). Both clarithromycin and erythromycin were ...
It is believed that effective therapy for MAC disease in patients with AIDS requires combinations of two or more antimycobacterial agents in order to overcome drug resistance and the unfavorable influence of the profound immunosuppression associated with AIDS. Data suggest that clarithromycin may have substantial activity in two- or three-drug combination regimens with clofazimine, rifamycin derivatives, ethambutol, or the 4-quinolones.. Patients are randomized to one of three treatment arms containing clarithromycin in combination with ethambutol, rifabutin, or both. Clarithromycin alone is taken on days 1 through 3 to determine tolerance and rifabutin and/or ethambutol is added on day 3. AS PER AMENDMENT 7/2/97: Patients may elect to add ritonavir or indinavir to their treatment regimen. Treatment continues daily for 48 weeks. In the absence of a dose-limiting toxicity, those patients who are determined to be complete or partial responders continue on the regimen to which they were originally ...
Clarithromycin is a macrolide antibiotic. Clarithromycin fights bacteria in your body. Clarithromycin is used to treat many different types of bacterial infections affecting the skin and respiratory system. Clarithromycin is also used together with other medicines to treat stomach ulcers caused by Helicobacter pylori...
Clarithromycin is a new macrolide that has a longer half-life than erythromycin and is claimed to reach higher tissue concentrations. We aimed to investigate whether, following oral administration, the drug and its 14-hydroxy metabolite reach levels in lung tissue that are likely to be clinically effective against common respiratory pathogens. Ten patients undergoing diagnostic bronchoscopy received seven doses of clarithromycin, 500 mg b.i.d. orally. Bronchoscopy was performed at a mean time of 4.25 h after the last dose. At bronchoscopy, bronchial biopsies and bronchoalveolar lavage were performed. Clarithromycin and its 14-OH metabolite were measured in serum, bronchial biopsies, epithelial lining fluid (ELF) and alveolar cells. Mean levels of clarithromycin were 4.0 mg.l-1 in serum, 16.8 mg.kg in bronchial biopsies, 20.5 mg.l-1 in ELF and 372.7 mg.l-1 in alveolar cells. The equivalent levels of 14-OH metabolite were 0.7, 2.7, 1.9 and 38.6 mg.l-1, respectively. We conclude that there is ...
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Of the 125 patients, 30% had H. pylori isolates resistant to clarithromycin and 66% had isolates resistant to metronidazole. The researchers determined that clarithromycin resistance was associated with previous use of any macrolide antibiotic, while resistance to metronidazole was associated with previous use of metronidazole. Furthermore, the odds of isolates being resistant to clarithromycin increased with the increasing number of courses of macrolides received. In patients treated with clarithromycin-based regimens, the team found that treatment failed in 77% of those with clarithromycin-resistant H. pylori, and in 13% of those with clarithromycin-susceptible strains.. Dr Brian McMahons team concluded, "Previous use of macrolides and metronidazole is associated with H. pylori resistant to these antimicrobial agents". "Clarithromycin resistance is associated with a greater risk for failure with clarithromycin-based treatments". ...
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Clarithromycin ====== (1) An [[antibiotic]] drug used in the treatment of [[infections]]. It belongs to the family of drugs called macrolides. (2) A semisynthetic 14-membered ring macrolide [[antibiotic]]. Clarithromycin binds to the 50S ribosomal subunit and inhibits RNA-dependent [[protein]] synthesis in susceptible [[organism]]s. Clarithromycin has been shown to eradicate gastric MALT (mucosa-associated [[lymphoid tissue]]) [[lymphoma]]s, presumably due to the eradication of tumorigenic Helicobacter pylori infection. This agent also acts as a biological response modulator, possibly inhibiting [[angiogenesis]] and tumor growth through alterations in growth factor expression. Synonym: Abbott-56268 US brand name: Biaxin Abbreviation: CLARITH Chemical structure name: 6-O-Methylerythromycin ...
Сlarithromycin, sold under the brand name Biaxin, is an antibiotic used to treat various bacterial infections. This includes strep throat, pneumonia, skin infections, H. pylori infection, and Lyme disease, among others. Clarithromycin can be taken by mouth as a pill or liquid.. Clarithromycin is primarily used to treat a number of bacterial infections including: pneumonia, Helicobacter pylori and as an alternative to penicillin in strep throat. Other uses include: cat scratch disease and other infections due to bartonella, cryptosporidiosis, as a second line agent in Lyme disease and toxoplasmosis. It may also be used to prevent bacterial endocarditis in those who cannot take penicillin. It is effective against upper and lower respiratory tract infections, skin and soft tissue infections and helicobacter pylori infections associated with duodenal ulcers.. Clarithromycin was developed in 1980. It is on the World Health Organizations List of Essential Medicines, the most effective and safe ...
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1) An antibiotic drug used in the treatment of infections. It belongs to the family of drugs called macrolides. (2) A semisynthetic 14-membered ring macrolide antibiotic. Clarithromycin binds to the 50S ribosomal subunit and inhibits RNA-dependent protein synthesis in susceptible organisms. Clarithromycin has been shown to eradicate gastric MALT (mucosa-associated lymphoid tissue) lymphomas, presumably due to the eradication of tumorigenic Helicobacter pylori infection. This agent also acts as a biological response modulator, possibly inhibiting angiogenesis and tumor growth through alterations in growth factor expression. Synonym: Abbott-56268 US brand name: Biaxin Abbreviation: CLARITH Chemical structure name: 6-O-Methylerythromycin ...
Amoxicillin is a penicillin antibiotic. Clarithromycin is a macrolide antibiotic. These antibiotics fight bacteria in the body. Omeprazole decreases the amount of acid produced in the stomach. The combination of amoxicillin, clarithromycin, and omeprazole is used to prevent stomach ulcer caused by infection with...
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Berdasarkan penelitian baru, pemberian antibiotik Clarithromycin pada pasien yang sebelumnya telah menggunakan obat Penghambat Kanal Kalsium (Calcium-Channel Blocker) sebagai terapi antihipertensi diasosiasikan dengan peningkatan risiko rawat inap akibat gagal ginjal akut, hipotensi dan kematian. Latar belakang dilakukannya penelitian ini adalah karena obat-obat tersebut masih sering diresepkan secara bersamaan meskipun FDA mengharuskan pencantuman peringatan,"serious adverse reactions have been reported in patients taking clarithromycin concomitantly with CYP3A4 substrates, which includes hypotension with calcium-channel blockers metabolized by CYP3A4 (such as verapamil, amlodipine, diltiazem)". Tampaknya masih ada keraguan dokter dan apoteker tentang bahaya interaksi obat tersebut sehingga diperlukan studi baru untuk melihat seberapa besar risiko yang ditimbulkan karena peresepan obat-obat tersebut secara bersamaan. ...
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The team performed a pooled-data analysis of all studies on the sequential regimen.. The eradication rate was calculated according to gastroduodenal pathology, proton pump inhibitor used, antibiotic resistance, as well as clinical setting.. Compliance, side effects, and cost implications were also evaluated.. The researchers noted that, overall, more than 1800 patients have been treated with the sequential regimen.. The team found that such a therapy was superior to 7 to 10 days triple therapies in paediatric, adult and elderly patients.. The therapy achieved an eradication rate constantly higher than 90% at intention-to-treat analysis.. The team noted that primary clarithromycin resistance reduced the efficacy of such a therapy.. However, the success rate was significantly higher than that observed with the standard 7 to 10 days triple therapies.. Dr Zullos team concluded, "The 10-day sequential treatment regimen achieves higher eradication rates than standard triple therapies.". ...
As with other macrolides, clarithromycin has been reported to increase concentrations of HMG-CoA reductase inhibitors (e.g., lovastatin and simvastatin). Rare reports of rhabdomyolysis have been reported in patients taking these drugs concomitantly. Omeprazole. Clarithromycin (500 mg every 8 hours) was given in combination with omeprazole (40 mg daily) to healthy adult subjects. The steady-state plasma concentrations of omeprazole were increased (Cmax, AUC0-24, and t1/2 increased by 30%, 89%, and 34%, respectively), by the concomitant administration of clarithromycin. The mean 24-hour gastric pH value was 5.2 when omeprazole was administered alone and 5.7 when omeprazole was co-administered with clarithromycin. Oral anticoagulants. Spontaneous reports in the post-marketing period suggest that concomitant administration of clarithromycin and oral anticoagulants may potentiate the effects of the oral anticoagulants. Prothrombin times should be carefully monitored while patients are receiving ...
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Pronunciation guide (phonetic spelling and recorded audio) of clarithromycin, also known as Biaxin, which is a Top 250 Drug in the drug class of Macrolide antibiotic.
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This study is investigating the drug interactions between dabigatran etexilate and clarithromycin in patients with healthy subjects. The primary endpoint is the
Here are some methods recommended by the CDC for how to ensure that your method of birth control is the most effective:. Birth control pills may make other drugs less effective, such as analgesics and blood pressure medications.. Plus, a pharmacist answers common questions. The way people describe this varies according to personal expression, but it is usually best described as an expanding sensation behind the forehead as if the brain is growing larger with nowhere to go. Clarithromycin and birth control. Are you concerned when you receive an antibiotic prescription but you also take oral contraceptives? How can we improve it?. Asking questions and staying informed is the best way to ensure your health needs are being met. It is popular among students although many do not realise that it can reduce the effectiveness of the pill and its results may last for up to two months.. This page may be out of date. ...
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Indian drug maker Ranbaxy Laboratories Ltd. has a launched a generic version of the anti-infective drug clarithromycin in the U.K. after winning a patent infringement lawsuit brought by U.S.-based Abbott Laboratories.
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The present meta-analysis, involving 20,819,622 individuals from 33 studies, found significantly increased risk of SCD or VTA, cardiovascular death, and MI in users of macrolides. This association with increased CV risk seemed to be present with current use of macrolides and disappeared for former use. In stratified analysis, azithromycin, clarithromycin, and erythromycin were associated with increased risk of SCD or VTA and azithromycin and clarithromycin with increased risk of CV death, but only clarithromycin was associated with increased risk of all-cause mortality. In terms of absolute risk, use of macrolides would account for an estimated 118.1 SCD or VTAs, 36.6 SCDs, and 38.2 cardiac deaths per 1 million courses.. Interpretation of the clinical importance of this finding is delicate. The estimates for additional SCDs and cardiac deaths per 1 million treatment courses are remarkably close, suggesting that most VTA observed in the macrolide groups might not result in fatal outcomes. The ...
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Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.. Abnormal heart rhythm: Clarithromycin may cause a heart rhythm problem called QT prolongation. If you have a history of QT prolongation, a medical condition associated with QT prolongation, or are taking certain medications (e.g., amiodarone, sotalol), discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.. Allergy: If you have had some form of allergy to erythromycin or azithromycin, you may be more likely to have an allergic reaction to this medication. If you develop symptoms of an allergic reaction such as a rash, contact your ...
Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.. Abnormal heart rhythm: Clarithromycin may cause a heart rhythm problem called QT prolongation. If you have a history of QT prolongation, a medical condition associated with QT prolongation, or are taking certain medications (e.g., amiodarone, sotalol), discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.. Allergy: If you have had some form of allergy to erythromycin or azithromycin, you may be more likely to have an allergic reaction to this medication. If you develop symptoms of an allergic reaction such as a rash, contact your ...
1 In patients requiring antibiotic therapy, make rational choices (i.e., first-line therapies, knowledge of local resistance patterns, patients medical and drug history, patients context). H Pylori Infection - 1st line Tx: Amoxicillin 1g bid + Clarithromycin 500mg bid + Pantoprazole 40mg bid x 7 days Alt: Metronidazole 500mg bid + Clarithromycin 500mg bid + Pantoprazole 40mg…
Israels Teva Pharmaceutical Industries, currently jostling with Sandoz for the top slot in the global generics sector, and US firm Ivax Laboratories have been granted final approval for two formulations of the antibiotic clarithromycin in the US, which is sold by Abbott Laboratories in the USA under the Biaxin brand name. - News - PharmaTimes
Special Considerations During Pregnancy. The diagnosis of bacterial respiratory tract infections in pregnant women is the same as in those who are not pregnant, with appropriate shielding of the abdomen during radiographic procedures. Bacterial respiratory tract infections should be managed as in women who are not pregnant, with certain exceptions. Clarithromycin is not recommended as the first-line agent among macrolides because of an increased risk of birth defects seen in some animal studies. Two studies, each involving at least 100 women with first-trimester exposure to clarithromycin, did not document a clear increase in or specific pattern of birth defects, although an increased risk of spontaneous abortion was noted in one study.55,56 Azithromycin did not produce birth defects in animal studies, but experience with human use in the first trimester is limited. Azithromycin is recommended when a macrolide is indicated in pregnancy (BIII). Arthropathy has been noted in immature animals with ...
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Clarithromycin use in patients who are receiving theophylline may be associated with an increase of serum theophylline concentrations. Monitoring of serum theophylline concentrations should be considered for patients receiving high doses of theophylline or with baseline concentrations in the upper therapeutic range. In two studies in which theophylline was administered with clarithromycin (a theophylline sustained-release formulation was dosed at either 6.5 mg/kg or 12 mg/kg together with 250 or 500 mg q12h clarithromycin), the steady-state levels of Cmax, Cmin, and the area under the serum concentration time curve (AUC) of theophylline increased about 20%.. Concomitant administration of single doses of clarithromycin and carbamazepine has been shown to result in increased plasma concentrations of carbamazepine. Blood level monitoring of carbamazepine may be considered.. When clarithromycin and terfenadine were coadministered, plasma concentrations of the active acid metabolite of terfenadine ...
AIM: To assess the efficacy and safety of ranitidine bismuth citrate plus clarithromycin given for 1 wk in Brazilian patients with peptic ulcer. METHODS: One hundred and twenty patients with peptic ulcer were randomized in two treatment groups: (1) 1-wk regimen consisting of ranitidine bismuth citrate 400 mg b.i.d. with clarithromycin 500 mg b.i.d. or (2) 2-wk regimen of the same treatment. Eradication of the infection was considered when both the histologic examination and the urease test were negative for the infection 3 mo after treatment. RESULTS: By intention to treat analysis, Helicobacter pylori (H pylori) was eradicated in 73% and 76% of patients, respectively treated for 1 or 2 wk (P,0.05). By per protocol analysis, the eradication rates were 80% and 83%, respectively, in patients treated for 1 or 2 wk (P,0.05). Nine patients (8.2%) reported minor side effects. CONCLUSION: One-week therapy with ranitidine bismuth citrate and clarithromycin is safe, well tolerated and effective for ...
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Ranitidine bismuth citrate was compared with an equipotent dose of ranitidine, to determine whether the former, by an anti-Helicobacter pylori activity, would counteract the rise of gastrin resulting from ranitidines gastric acid antisecretory activity. Twenty four men with duodenal ulcers were studied before and on the 8th day of dosing with either ranitidine bismuth citrate 800 mg twice daily or ranitidine 300 mg twice daily (double blind, randomised, parallel groups). Fasting and postprandial plasma gastrin and plasma pepsinogen I and II concentrations were measured, and a 13C-urea breath test was performed before and on the 8th day of dosing. The 13C-urea breath tests were positive in 21 patients before dosing and remained positive in nine of nine of the ranitidine dosed patients, whereas only two of 12 patients treated with ranitidine bismuth citrate remained positive. The expected rise in meal stimulated plasma gastrin with ranitidine was seen in the 12 patients who received ranitidine ...
Background & Aims: Mycobacterium avium subspecies paratuberculosis has been proposed as a cause of Crohns disease. We report a prospective, parallel, placebo-controlled, double-blind, randomized trial of 2 years of clarithromycin, rifabutin, and clofazimine in active Crohns disease, with a further year of follow-up. Methods: Two hundred thirteen patients were randomized to clarithromycin 750 mg/day, rifabutin 450 mg/day, clofazimine 50 mg/day or placebo, in addition to a 16-week tapering course of prednisolone. Those in remission (Crohns Disease Activity Index ≤150) at week 16 continued their study medications in the maintenance phase of the trial. Primary end points were the proportion of patients experiencing at least 1 relapse at 12, 24, and 36 months. Results: At week 16, there were significantly more subjects in remission in the antibiotic arm (66%) than the placebo arm (50%; P = .02). Of 122 subjects entering the maintenance phase, 39% taking antibiotics experienced at least 1 relapse ...
The aim of this study was to determine the resistance rates of Helicobacter pylori (H. pylori) to various antimicrobial agents. The agar disk diffusion method (Kirby Bauer) was used to determine the sensitivity of H. pylori isolates to various antimicrobials. Of the 61 H. pylori isolatestested, no isolates was resistant to amoxycillin and tetracycline. The resistance rates were 42.6% for metronidazole, 21.3% for clarithromycin, and 3.3% for levofloxacin. Compared to clarithromycin and metronidazole, levofloxacin showed the lowest resistance. This is the first report on the resistance rates of H. pylori to antibiotics in Elazig Province, East of Turkey. This study suggests that the large scale studies is needed to help us to understand better the effect of resistance on the H. pylori eradication.
A 51-year-old woman presented with complaints of dyspnea, fatigue, and non-productive cough. Chest X-ray showed bilateral lung infiltrates. Nonspecific air-space consolidation on anterior segment of the right lower lobe, bilateral bronchiectasis and infiltrates, patchy ground-glass opacities, and interstitial thickening were reported on thorax computed tomography which was non-responsive to antibiotics. After tru-cut biopsy which only revealed a single granuloma in a particular area, alveolar septal thickening and fibrosis, slight chronic inflammation with findings of congestion, lung involvement was considered to be associated with nonspecific interstitial pneumonia. The nails on all fingers displayed yellow discoloration with mild edema in the face and the legs. The final diagnosis was yellow nail syndrome. Short-term clarithromycin and long-term oral methylprednisolone with vitamin E treatment were successful. After 4 months, all components of the syndrome almost completely ...
BACKGROUND/AIMS A two-year, prospective, nationwide multicenter study was undertaken to evaluate the effect of Helicobacter pylori eradication on the development of reflux esophagitis (RE) and gastroesophageal reflux disease (GERD) symptoms in the Korean population. METHODS In total, 1,489 subjects without RE were enrolled at the outpatient clinics of 12 tertiary hospitals nationwide, and 452 subjects underwent follow-up (F/U) for 2 years to evaluate the development of RE and GERD symptoms. RESULTS RE was found in 33 subjects (7.3% of 452 subjects) and 14 subjects (7.3% of 192 subjects) during the first and second year of F/U, respectively. H. pylori status was not associated with the development of RE. RE was found in six (9.0%) of 67 H. pylori-negative patients, in 26 (11.2%) of 233 eradicated subjects and in eight (7.0%) of 114 noneradicated subjects (p=0.532). Multivariate analysis showed that age ≥60 years (odds ratio [OR], 7.11; 95% confidence interval [CI], 1.92 to 26.41), alcohol
Abstract: Prevalence of Helicobacter pylori infection in Indonesia was 36-46%. In Jakarta and Surabaya, the prevalence were 85,7%-93,9%. Helicobacter pylori infection play role in pathogenesis of pectic ulcers, chronic gastritis, carcinoma of gaster and gastric lymphoma. Epidemiologic study showed 80% of carcinoma of gaster related with H pylori infection.This study analyzed expression of anti-Helicobacter pylori in chronic gastritis, precancer lesion , and carcinoma of gaster. This study was a observational descriptive study with case control design. Thirty (30) samples from paraffin bloc that were diagnosed with chronic gastritis, precancer lesion, and carcinoma of gaster at Dokter Kariadi hospital in 2013 was stained by hematoxylin eosin, giemsa and immunohistochemistry of anti-helicobacter pylori. Data was analyzed by descriptive analysis. Thirty (30) samples were diagnosed as gastritis chronis 13 (43,3% ), pra cancer lesion(36.6%), and carcinoma(20.1%). Chronic gastritis can be occurred at ...

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