Citrate (si)-Synthase
Citric Acid
Potassium Citrate
Oxo-Acid-Lyases
Calcium Citrate
Clomiphene
Tricarboxylic Acids
Malates
Oxaloacetates
Gallium Radioisotopes
Aconitate Hydratase
Isocitrates
Aluminum
Isocitrate Dehydrogenase
Oxaloacetic Acid
Ketoglutaric Acids
Malate Dehydrogenase
Acetyl Coenzyme A
Sulfones
Acetates
Coenzyme A
Dicarboxylic Acid Transporters
Hydrogen-Ion Concentration
Aconitic Acid
Ranitidine
Gallium
Phosphofructokinase-1
Pyruvates
Purines
Leuconostoc
Iron
Carboxylic Acids
Glucose
Acetyl-CoA Carboxylase
Kidney Calculi
Pyruvic Acid
Ovulation Induction
Anovulation
Carbon Isotopes
Mitochondria
Oxalates
Carbon-Sulfur Ligases
Enterobacter
Succinates
Carboxy-Lyases
Culture Media
Dicarboxylic Acids
Carrier Proteins
Biological Transport
Pyruvate Carboxylase
Glutamates
Ketoglutarate Dehydrogenase Complex
Urinary Calculi
Molecular Sequence Data
Fumarate Hydratase
Oxidation-Reduction
Escherichia coli
Glycolysis
Calcium Oxalate
3-Hydroxyacyl CoA Dehydrogenases
Piperazines
Ligases
Geobacter
Magnesium
Acetoin
Edetic Acid
Anaerobiosis
Quaternary Ammonium Compounds
Oxalic Acid
Serotonin 5-HT4 Receptor Agonists
Lactic Acid
Oxygen Consumption
Phosphofructokinases
Anions
Iron Radioisotopes
Mitochondria, Muscle
Succinic Acid
Liver
Lyases
NAD
Bicarbonates
Fluoroacetates
Klebsiella pneumoniae
Buffers
Fermentation
Organic Anion Transporters
Fatty Acids
Mitochondria, Liver
Diethylcarbamazine
Adenosine Triphosphate
Burns, Chemical
Glutarates
Hexosediphosphates
Acidosis
Klebsiella
L-Lactate Dehydrogenase
Erectile Dysfunction
Anti-Ulcer Agents
Lactococcus lactis
Transferrin
Gluconates
Muscle, Skeletal
Amino Acid Sequence
Polycystic Ovary Syndrome
Hemofiltration
Iron Chelating Agents
Phosphodiesterase Inhibitors
Gene Expression Regulation, Bacterial
Plutonium
Tartrates
Organometallic Compounds
Multienzyme Complexes
Urolithiasis
Rhodopseudomonas
Fructosephosphates
Carbohydrate Metabolism
Hexosephosphates
Malonyl Coenzyme A
Chelating Agents
Senna Extract
Proton-Motive Force
Plant Roots
Sodium
Heparin
Pregnancy Rate
Medullary Sponge Kidney
Siderophores
Pyruvate Dehydrogenase Complex
Malonates
Bisacodyl
Butanones
Hemodiafiltration
Adenine Nucleotides
Energy Metabolism
Sodium Bicarbonate
Clarithromycin
Bartonella
Calcium
Calcium Chloride
Mutation
Base Sequence
Solutions
Fructosediphosphates
Carbon
Cloning, Molecular
Ketone Bodies
Substrate Specificity
Biological Transport, Active
Sodium Acetate
Dose-Response Relationship, Drug
Carbon Dioxide
Acyl Coenzyme A
Magnetic Resonance Spectroscopy
Rats, Inbred Strains
Swine
Temperature
Sodium Hydroxide
Amino Acids
Glutamine
Rickettsia
Succinate Dehydrogenase
Myocardium
Acid-Base Equilibrium
Deltaproteobacteria
Deferoxamine
Insemination, Artificial, Homologous
Acetylcarnitine
Rats, Wistar
Aspartic Acid
Radionuclide Imaging
Adenosine Monophosphate
Urinalysis
Cell-Free System
Segmental colonic transit after oral 67Ga-citrate in healthy subjects and those with chronic idiopathic constipation. (1/1622)
Measurement of segmental colonic transit is important in the assessment of patients with severe constipation. 111In-diethylenetriamine pentaacetic acid (DTPA) has been established as the tracer of choice for these studies, but it is expensive and not readily available. 67Ga-citrate is an inexpensive tracer and when given orally is not absorbed from the bowel. It was compared with 111In-DTPA in colonic transit studies in nonconstipated control subjects and then in patients with idiopathic constipation. METHODS: Studies were performed after oral administration of 3 MBq (81 microCi) 67Ga-citrate or 4 MBq (108 microCi) 111In-DTPA in solution. Serial abdominal images were performed up to 96 h postinjection, and computer data were generated from geometric mean images of segmental retention of tracer, mean activity profiles and a colonic tracer half-clearance time. RESULTS: There were no differences in segmental retention of either tracer or in mean activity profiles between control subjects and constipated patients. Results in constipated subjects were significantly different from those in controls. The mean half-clearance times of tracer for control subjects were 28.8 h for 67Ga-citrate and 29.9 h for 111In-DTPA in control subjects and 75.0 h for 67Ga-citrate and 70.8 h for 111In-DTPA in constipated patients. CONCLUSION: Oral 67Ga-citrate can be used as a safe alternative to 111In-DTPA for accurate measurement of segmental colonic transit. (+info)Mechanism of citrate metabolism in Lactococcus lactis: resistance against lactate toxicity at low pH. (2/1622)
Measurement of the flux through the citrate fermentation pathway in resting cells of Lactococcus lactis CRL264 grown in a pH-controlled fermentor at different pH values showed that the pathway was constitutively expressed, but its activity was significantly enhanced at low pH. The flux through the citrate-degrading pathway correlated with the magnitude of the membrane potential and pH gradient that were generated when citrate was added to the cells. The citrate degradation rate and proton motive force were significantly higher when glucose was metabolized at the same time, a phenomenon that could be mimicked by the addition of lactate, the end product of glucose metabolism. The results clearly demonstrate that citrate metabolism in L. lactis is a secondary proton motive force-generating pathway. Although the proton motive force generated by citrate in cells grown at low pH was of the same magnitude as that generated by glucose fermentation, citrate metabolism did not affect the growth rate of L. lactis in rich media. However, inhibition of growth by lactate was relieved when citrate also was present in the growth medium. Citrate did not relieve the inhibition by other weak acids, suggesting a specific role of the citrate transporter CitP in the relief of inhibition. The mechanism of citrate metabolism presented here provides an explanation for the resistance to lactate toxicity. It is suggested that the citrate metabolic pathway is induced under the acidic conditions of the late exponential growth phase to make the cells (more) resistant to the inhibitory effects of the fermentation product, lactate, that accumulates under these conditions. (+info)Imaging experimental intraabdominal abscesses with 99mTc-PEG liposomes and 99mTc-HYNIC IgG. (3/1622)
OBJECTIVE: To evaluate the accuracy of technetium-99m-labeled polyethylene glycol-coated liposomes (99mTc-PEG liposomes) and technetium-99m-labeled nonspecific human immunoglobulin G (99mTc-HYNIC IgG) for the scintigraphic detection of experimental intraabdominal abscesses in comparison with that of a standard agent, gallium-67 citrate. BACKGROUND: Scintigraphic imaging techniques can be very useful for the rapid and accurate localization of intraabdominal abscesses. Two newly developed radiolabeled agents, 99mTc-PEG liposomes and 99mTc-HYNIC IgG, have shown to be excellent agents for imaging experimental focal infection, but have not yet been studied in the detection of abdominal abscesses. METHODS: Intraabdominal abscesses were induced in 42 rats using the cecal ligation and puncture technique. Seven days later, randomized groups of rats received 99mTc-PEG liposomes, 99mTc-HYNIC IgG, or 67Ga citrate intravenously. The rats were imaged up to 24 hours after the injection. The biodistribution of the radiolabel was determined by counting dissected tissues ex vivo. Macroscopic intraabdominal abnormalities and focal uptake on the images were independently scored on a semiquantitative scale. RESULTS: 99mTc-PEG liposomes provided the earliest scintigraphic visualization of the abscess (as soon as 2 hours after the injection vs. 4 hours for the other two agents). Liposomes, IgG, and gallium all showed similarly high absolute uptake in the abscess. Focal uptake of liposomes and gallium correlated best with the extent of the macroscopic abnormalities. CONCLUSIONS: 99mTc-PEG liposomes and 99mTc-HYNIC IgG performed at least as well as the standard agent, 67Ga citrate, in the detection of experimental intraabdominal abscesses, with obvious advantages such as lower radiation exposure and more favorable physical properties. Of the two technetium agents, the liposomes seemed to be superior, providing the earliest diagnostic image and the best correlation with the inflammatory abnormalities. In addition, the preferential localization of radiolabeled PEG liposomes holds promise for targeted delivery of liposome-encapsulated drugs. (+info)Metabolic behaviour and cleavage capacity in the amphibian egg. (4/1622)
During the winter season the full grown Bufo arenarum oocyte shows the metabolic behaviour characteristic of differentiated tissues of the same species. Due to seasonal variations, during the amplexus period, it acquires the metabolic behaviour of the segmenting egg. Short-time-induced ovulations (5-6 h) determine germinal vesicle breakdown immediately before the expulsion of the oocyte, without modifying the ovarian metabolism of the same. The incidence of the operative type of metabolism upon their capacity to cleave after insemination and needle pricking, has been studied in coelomic oocytes, which have attained nuclear maturation and have not experienced oviducal secretion effects. The results obtained indicate that the segmenting capacity of the egg is attained only when, through biochemical modifications, the oocyte acquires the metabolic behaviour characterizing embryonic cells. It is postulated that the metabolic changes observed in the oocyte constitue a fundamental aspect of cytoplasmic maturation. (+info)Differences in phosphofructokinase regulation in normal and tumor rat thyroid cells. (5/1622)
The kinetic and molecular properties of a phosphofructokinase derived from a transplantable rat thyroid tumor lacking regulatory control on the glycolytic pathway were studied. The properties of the near-purified enzyme (specific activity 140 units/mg) were compared with those of phosphofructokinase from normal rat thyroid (specific activity 134 units/mg). The electrophoretic mobilities and gel elution behavior of these two enzymes were almost similar. The thyroid tumor phosphofructokinase showed, however, a greater degree of size and/or shape heterogeneity in the presence of ATP than the normal thyroid enzyme, as determined by gel filtration and sucrose density gradient centrifugation. Kinetic studies below pH 7.4 showed a sigmoid response curve for both enzymes when the velocity was determined at 1 mM ATP with varying levels of fructose-6-P. The interaction coefficient, however, was 4.2 and 2.6 for normal and tumor thyroid phosphofructokinase, respectively. Ammonium sulfate decreased the cooperative interactions with the substrate fructose-6-P in both enzymes. The thyroid tumor enzyme, however, was less sensitive to the inhibition by ATP and by citrate. The reversal of citrate inhibition by cyclic 3':5'-adenosine monophosphate was also less effective with the thyroid tumor phosphofructokinase, while the protective effect of fructose-6-P was stronger. The difference in citrate inhibition between tumor and normal thyroid enzyme was not strongly affected by varying the MgCl2 concentration up to 10 mM. It is concluded that the complex allosteric regulation typical of the normal thyroid phosphofructokinase is still present in the enzyme isolated from the thyroid tumor tissue. The latter, however, is more loosely controlled by its physiological effectors, such as ATP, citrate, and cyclic AMP. (+info)Myositis ossificans demonstrated by positive gallium-67 and technetium-99m-HMDP bone imaging but negative technetium-99m-MIBI imaging. (6/1622)
Gallium-67-citrate and 99mTc-diphosphate bone imaging agents are localized in myositis ossificans, a tumor-like benign soft-tissue mass that makes it impossible to differentiate between malignant tumor and the infection/inflammatory process. We present such a myositis ossificans patient whose bone and 67Ga-citrate imagings showed increased uptake in the left thigh and two foci of the right gluteal region leading to inconclusive results. Technetium-99m-MIBI imaging showed the absence of substantial uptake in these regions. ACT scan confirmed myositis ossificans. The lack of 99mTc-MIBI uptake in myositis ossificans means that 99mTc-MIBI imaging may be useful in the differential diagnosis. (+info)Radiation exposure from gallium-67-citrate patients. (7/1622)
OBJECTIVE: Serial monitoring of patients was performed to determine the radiation exposure contributed by patients injected with 67Ga-citrate to their surroundings. Radiology and nursing staff distance exposure estimates were made for various patient care tasks and imaging tests. METHODS: Fifteen adult patients were surveyed early (mean 4.3 min) and 11 of the 15 were surveyed at 3 d (mean 68.8 h) postinjection. The standard adult lymphoma imaging activity of 333-407 MBq (9-11 mCi) resulted in a range of 3.7-8.1 MBq/kg (0.1-0.22 mCi/kg). Dose rate measurements were made in the anterior, posterior, and left and right lateral projections at the level of the umbilicus, at distances of patient's surface and at 30.5 cm and 100 cm with a calibrated ion chamber. Time of contact-routine task analyses also were obtained for nursing and radiology personnel. Using a radiation survey-derived biexponential pharmacokinetic relationship, radiation exposures were determined for hospital personnel and family members at various times after injection. RESULTS: Based on the study population survey results, the mean instantaneous exposures (microSv/h) for an administered activity of 370 MBq (10 mCi) 67Ga-citrate were determined. The task analyses revealed the maximum patient contact time for any procedure performed at a distance equal to, or less than, 30.5 cm was 30 min. CONCLUSION: The quantitation of radiation exposure scenarios from 67Ga-citrate patients has determined that no special precautions are necessary for medical personnel when performing routine tasks associated with these patients. (+info)Randomised trial of two pharmacological methods of bowel preparation for day case colonoscopy. (8/1622)
AIMS: To undertake a prospective, single blind, randomised trial comparing the efficacy and tolerance of two outpatient colonoscopy bowel preparation regimens. METHODS: Patients aged between 18 months and 16 years being admitted for day case colonoscopy were allocated randomly to receive either Picolax (an oral, sugar free powder containing sodium picosulphate 10 mg/sachet with magnesium citrate) and clear fluids or bisacodyl tablets with an unrestricted diet and a phosphate enema just before colonoscopy. Patient compliance, bowel frequency, and associated symptoms were recorded, and the adequacy of the bowel preparation was assessed in a blinded manner. RESULTS: 63 of 66 patients completed the trial. Mean age, mean weight, extent of colonoscopy, and distribution of underlying pathology were similar in both groups. Bowel preparation was good or excellent in all of the patients in the Picolax group (n = 32) compared with 22 patients in the bisacodyl/phosphate enema group (n = 31). The latter group experienced more abdominal discomfort during bowel preparation but three of the Picolax group vomited and the lack of solid food distressed some children. CONCLUSIONS: All bowel preparation methods have limitations and unpleasant side effects but the use of Picolax and clear fluids proved superior to bisacodyl tablets and a phosphate enema in children undergoing day case colonoscopy. (+info)Citric acid is a naturally occurring organic acid that is commonly found in citrus fruits such as lemons, oranges, and limes. In the medical field, citric acid is used in a variety of applications, including as a preservative, a flavoring agent, and a pH adjuster. One of the primary uses of citric acid in medicine is as an antacid. It is often used to treat heartburn, acid reflux, and other conditions that are caused by excess stomach acid. Citric acid works by neutralizing the acid in the stomach, which can help to reduce symptoms such as pain, burning, and discomfort. Citric acid is also used in some over-the-counter medications as a decongestant. It works by breaking up mucus in the respiratory tract, which can help to relieve congestion and other respiratory symptoms. In addition to its medicinal uses, citric acid is also used in a variety of other applications in the medical field. For example, it is used as a preservative in some medical devices and as a pH adjuster in certain laboratory procedures. It is also used as a food additive in some dietary supplements and as a flavoring agent in some oral care products.
Potassium citrate is a salt that is formed by combining potassium ions with citric acid molecules. It is a white, odorless, crystalline powder that is commonly used in the medical field as a medication to treat a variety of conditions. One of the main uses of potassium citrate is to treat kidney stones. It works by increasing the amount of citrate in the urine, which can help to prevent the formation of new stones and can also help to dissolve existing stones. Potassium citrate is also used to treat acidosis, a condition in which the blood is too acidic. It can help to raise the pH of the blood and bring it back to a normal range. In addition to its use as a medication, potassium citrate is also used as a dietary supplement. It is often added to sports drinks and other beverages to help replenish electrolytes lost during exercise. It is also used in some dietary supplements to help support healthy kidney function and to prevent the formation of kidney stones. Overall, potassium citrate is a versatile compound that has a number of important uses in the medical field. It is generally considered safe when taken as directed, but it is important to talk to a healthcare provider before using it, especially if you have any underlying health conditions or are taking other medications.
Oxo-acid lyases are a class of enzymes that catalyze the cleavage of an oxo-acid substrate at the carbon-carbon bond adjacent to the oxygen atom. These enzymes are involved in various metabolic pathways and play important roles in the breakdown of amino acids, carbohydrates, and fatty acids. In the medical field, oxo-acid lyases are often studied in the context of their involvement in diseases such as cancer, diabetes, and obesity. For example, certain enzymes in this class have been shown to be upregulated in cancer cells, leading to increased metabolism and proliferation. In diabetes and obesity, alterations in the activity of oxo-acid lyases have been linked to impaired glucose metabolism and the development of insulin resistance. Overall, oxo-acid lyases are an important class of enzymes that play a critical role in metabolism and have implications for various diseases.
Calcium citrate is a compound that is formed by combining calcium ions with citric acid molecules. It is a common dietary supplement and is used to increase calcium levels in the body. Calcium is an essential mineral that is important for maintaining strong bones and teeth, as well as for many other functions in the body. Calcium citrate is often used as a dietary supplement because it is easily absorbed by the body and is less likely to cause constipation than other forms of calcium supplements. It is also used in some medications to treat certain conditions, such as osteoporosis and high blood pressure.
Clomiphene is a medication that is used to stimulate ovulation in women who are not ovulating on their own. It is typically prescribed to women who are trying to conceive but are having difficulty ovulating due to polycystic ovary syndrome (PCOS) or other hormonal imbalances. Clomiphene works by blocking the action of estrogen in the body, which can help to stimulate the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH). These hormones are important for ovulation, and clomiphene can help to increase their levels and promote ovulation in women who are not ovulating on their own. Clomiphene is usually taken for five days in a row, starting on the second or third day of a woman's menstrual cycle. It is usually taken in combination with other fertility medications, such as gonadotropins, to increase the chances of successful ovulation and pregnancy.
Tricarboxylic acids, also known as TCA cycle or citric acid cycle, is a metabolic pathway that occurs in the mitochondria of cells. It is a series of chemical reactions that generates energy in the form of ATP (adenosine triphosphate) and NADH (nicotinamide adenine dinucleotide) from glucose and other organic molecules. During the TCA cycle, glucose is broken down into smaller molecules, and the energy stored in these molecules is released in the form of ATP and NADH. The TCA cycle also plays a crucial role in the synthesis of other important molecules, such as amino acids and fatty acids. In the medical field, the TCA cycle is important for understanding various metabolic disorders, such as diabetes, where the body is unable to properly regulate blood sugar levels. It is also important in the treatment of certain diseases, such as cancer, where the TCA cycle is often altered to support the growth and survival of cancer cells.
Malates are a group of organic compounds that are commonly found in plants and some microorganisms. In the medical field, malates are often used as a dietary supplement or as a component in certain medications. One of the most well-known uses of malates is in the treatment of metabolic disorders such as diabetes and obesity. Malates have been shown to improve insulin sensitivity and glucose metabolism, which can help to regulate blood sugar levels and reduce the risk of complications associated with these conditions. Malates are also used in the treatment of liver disease, as they can help to protect liver cells from damage and promote liver function. In addition, malates have been shown to have anti-inflammatory properties, which may make them useful in the treatment of a variety of inflammatory conditions. Overall, malates are a versatile compound with a range of potential health benefits. However, more research is needed to fully understand their mechanisms of action and potential therapeutic applications.
Oxaloacetates are organic compounds that contain the functional group -COO-CH2-COO-. They are important intermediates in various metabolic pathways in the body, particularly in the citric acid cycle (also known as the Krebs cycle or TCA cycle) and in the synthesis and breakdown of amino acids. In the citric acid cycle, oxaloacetate is converted into citrate, which is then used to produce energy in the form of ATP. In amino acid metabolism, oxaloacetate is involved in the synthesis of aspartate and alanine, as well as in the breakdown of certain amino acids such as leucine and isoleucine. Oxaloacetates are also used in the synthesis of other important compounds such as glucose and fatty acids.
Gallium radioisotopes are radioactive isotopes of the element gallium that are used in medical imaging and diagnostics. These isotopes are typically produced by bombarding a target material with high-energy particles, such as protons or neutrons, in a nuclear reactor or particle accelerator. There are several different gallium radioisotopes that are used in medical imaging, including gallium-67 (Ga-67), gallium-68 (Ga-68), and gallium-72 (Ga-72). Ga-67 is the most commonly used gallium radioisotope in medical imaging, and it is typically used to diagnose and monitor a variety of conditions, including infections, tumors, and inflammatory diseases. Ga-68 is a newer radioisotope that is used in positron emission tomography (PET) imaging, which is a type of medical imaging that uses small amounts of radioactive material to create detailed images of the body's internal structures. Ga-68 is typically used to diagnose and monitor cancer, as well as to evaluate the effectiveness of certain treatments. Ga-72 is a radioisotope that is currently being studied for its potential use in medical imaging, but it has not yet been widely used in clinical practice.
In the medical field, ferric compounds refer to compounds that contain the ferric ion (Fe3+), which is a form of iron. Ferric compounds are commonly used in the treatment of iron deficiency anemia, a condition in which the body does not have enough iron to produce healthy red blood cells. There are several types of ferric compounds that are used in medical treatment, including ferrous sulfate (also known as iron sulfate), ferrous fumarate, ferrous gluconate, and ferric carboxymaltose. These compounds are typically administered orally or intravenously, and they work by providing the body with the iron it needs to produce red blood cells. Ferric compounds can also be used to treat other conditions, such as iron overload disorders, where the body has too much iron. In these cases, ferric compounds may be used to remove excess iron from the body through a process called chelation therapy. It is important to note that ferric compounds can have side effects, such as nausea, vomiting, constipation, and dark stools. It is also important to follow the recommended dosage and to speak with a healthcare provider if you have any questions or concerns about taking ferric compounds.
Aconitate hydratase is an enzyme that plays a role in the citric acid cycle, also known as the Krebs cycle or tricarboxylic acid cycle. It is responsible for converting aconitase to cis-aconitate, which is an important step in the breakdown of fatty acids and amino acids for energy production in the body. A deficiency in aconitate hydratase can lead to a rare genetic disorder called aconitase deficiency, which can cause a range of symptoms including muscle weakness, developmental delays, and seizures.
Isocitrate is a metabolic intermediate that is involved in the citric acid cycle, also known as the Krebs cycle or tricarboxylic acid cycle. It is a six-carbon compound that is produced when glucose is metabolized in the body. In the medical field, isocitrate is often used as a diagnostic tool to help identify certain metabolic disorders. For example, elevated levels of isocitrate in the blood or urine can be a sign of a genetic disorder called isocitrate dehydrogenase deficiency, which is a rare condition that affects the metabolism of certain amino acids and fatty acids. Isocitrate is also used as a precursor in the synthesis of other important molecules in the body, such as cholesterol and other lipids. In addition, it has been studied for its potential therapeutic uses in the treatment of various diseases, including cancer, Alzheimer's disease, and diabetes.
In the medical field, aluminum is a metal that is commonly used in various medical devices and implants. It is often used in orthopedic implants, such as hip and knee replacements, due to its strength, durability, and biocompatibility. However, aluminum has also been linked to certain health problems, particularly in individuals with kidney disease or other conditions that affect the body's ability to excrete aluminum. Long-term exposure to high levels of aluminum has been associated with an increased risk of Alzheimer's disease, Parkinson's disease, and other neurological disorders. Therefore, in the medical field, the use of aluminum in medical devices and implants is carefully regulated to minimize the risk of aluminum exposure and potential health effects.
Isocitrate dehydrogenase (IDH) is an enzyme that plays a critical role in the citric acid cycle, also known as the Krebs cycle or tricarboxylic acid cycle. It catalyzes the conversion of isocitrate to alpha-ketoglutarate (α-KG) in the presence of NAD+ as a cofactor. This reaction is an important step in the production of energy in the form of ATP through cellular respiration. In the medical field, IDH is of particular interest because mutations in the IDH1 and IDH2 genes have been implicated in the development of certain types of cancer, including gliomas, acute myeloid leukemia, and chondrosarcoma. These mutations result in the production of an abnormal form of the enzyme that has altered activity and can lead to the accumulation of alpha-ketoglutarate, which can promote tumor growth and progression. As a result, IDH mutations are now considered important biomarkers for the diagnosis and prognosis of certain types of cancer, and targeted therapies that inhibit the activity of mutant IDH enzymes are being developed for their treatment.
Bismuth is a chemical element that is used in the medical field as an active ingredient in certain medications. It is most commonly used in combination with other medications to treat stomach ulcers and acid reflux. Bismuth also has antidiarrheal properties and has been used to treat bacterial infections, such as salmonellosis and shigellosis. In addition, bismuth has been used in the treatment of certain skin conditions, such as acne and rosacea. It is usually taken as a medication in the form of a tablet or capsule.
Oxaloacetic acid is a four-carbon dicarboxylic acid that plays a central role in the citric acid cycle, also known as the Krebs cycle or tricarboxylic acid cycle. It is a key intermediate in the metabolism of carbohydrates, fats, and proteins, and is involved in the production of energy in the form of ATP. In the citric acid cycle, oxaloacetic acid is produced from the condensation of acetyl-CoA and oxaloacetate. It is then converted to malate, which can be transported to the mitochondria for further metabolism or converted back to oxaloacetate to continue the cycle. Oxaloacetic acid is also involved in the synthesis of other important molecules in the body, such as amino acids, nucleotides, and heme. It is a precursor to aspartate, which is used in the synthesis of asparagine, glutamate, and other amino acids. In the medical field, oxaloacetic acid is not typically used as a therapeutic agent. However, it is an important molecule in the metabolism of the body and is involved in the production of energy. Abnormalities in the metabolism of oxaloacetic acid can lead to a variety of metabolic disorders, such as maple syrup urine disease, which is caused by a deficiency in the enzyme that converts oxaloacetic acid to aspartate.
Ketoglutaric acid is a chemical compound that is involved in the metabolism of amino acids in the body. It is a key intermediate in the citric acid cycle, also known as the Krebs cycle or the tricarboxylic acid cycle, which is a series of chemical reactions that generate energy in the form of ATP (adenosine triphosphate) from glucose and other nutrients. In the medical field, ketoglutaric acid is sometimes used as a dietary supplement or as a treatment for certain medical conditions. For example, it has been suggested that ketoglutaric acid may have potential as a treatment for cancer, as it has been shown to have anti-tumor effects in some studies. It has also been suggested that ketoglutaric acid may have potential as a treatment for other conditions, such as Alzheimer's disease and Parkinson's disease, although more research is needed to confirm these potential benefits. It is important to note that the use of ketoglutaric acid as a dietary supplement or as a treatment for medical conditions is not well-established, and more research is needed to fully understand its potential benefits and risks. It is always a good idea to talk to a healthcare professional before starting any new supplement or treatment.
Malate dehydrogenase (MDH) is an enzyme that plays a crucial role in cellular metabolism. It catalyzes the conversion of malate, a four-carbon compound, to oxaloacetate, a five-carbon compound, in the citric acid cycle. This reaction is reversible and can occur in both directions, depending on the cellular needs and the availability of energy. In the medical field, MDH is often studied in the context of various diseases and disorders. For example, mutations in the MDH gene have been associated with certain forms of inherited metabolic disorders, such as Leigh syndrome and MELAS (mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes). In addition, MDH has been implicated in the development of certain types of cancer, such as breast and prostate cancer, and may play a role in the progression of these diseases. Overall, MDH is an important enzyme in cellular metabolism and its dysfunction can have significant implications for human health.
Acetyl Coenzyme A (Acetyl-CoA) is a molecule that plays a central role in metabolism in all living organisms. It is a key intermediate in the breakdown of carbohydrates, fats, and proteins, and is involved in the synthesis of fatty acids, cholesterol, and ketone bodies. In the medical field, Acetyl-CoA is often studied in the context of diseases such as diabetes, obesity, and metabolic disorders. For example, in type 2 diabetes, the body's ability to regulate blood sugar levels is impaired, which can lead to an accumulation of Acetyl-CoA in the liver. This can cause the liver to produce more fatty acids and triglycerides, leading to the development of fatty liver disease. In addition, Acetyl-CoA is also involved in the production of energy in the form of ATP (adenosine triphosphate), which is the primary energy currency of the cell. Therefore, disruptions in Acetyl-CoA metabolism can have significant effects on energy production and overall health.
Sulfones are a class of organic compounds that contain a sulfur-oxygen double bond. They are often used as intermediates in the synthesis of other organic compounds, and they have a variety of applications in the medical field. One important use of sulfones in medicine is as anti-inflammatory agents. Sulfones such as sulfasalazine and mesalamine are used to treat inflammatory bowel diseases like ulcerative colitis and Crohn's disease. These drugs work by inhibiting the production of inflammatory chemicals in the body. Sulfones are also used as anticonvulsants, which are drugs that help prevent seizures. One example of a sulfone anticonvulsant is ethosuximide, which is used to treat epilepsy. In addition, sulfones have been studied for their potential use in treating cancer. Some sulfones have been shown to have anti-tumor activity, and they are being investigated as potential treatments for a variety of different types of cancer. Overall, sulfones have a variety of potential applications in the medical field, and they continue to be an active area of research and development.
In the medical field, acetates refer to compounds that contain the acetate ion (CH3COO-). Acetates are commonly used in the treatment of various medical conditions, including: 1. Hyperkalemia: Acetate is used to treat high levels of potassium (hyperkalemia) in the blood. It works by binding to potassium ions and preventing them from entering cells, which helps to lower potassium levels in the blood. 2. Acidosis: Acetate is used to treat acidosis, a condition in which the blood becomes too acidic. It works by increasing the production of bicarbonate ions, which helps to neutralize excess acid in the blood. 3. Respiratory failure: Acetate is used to treat respiratory failure, a condition in which the lungs are unable to provide enough oxygen to the body. It works by providing an alternative source of energy for the body's cells, which helps to support the respiratory system. 4. Metabolic acidosis: Acetate is used to treat metabolic acidosis, a condition in which the body produces too much acid. It works by increasing the production of bicarbonate ions, which helps to neutralize excess acid in the body. 5. Hyperammonemia: Acetate is used to treat hyperammonemia, a condition in which the blood contains too much ammonia. It works by providing an alternative source of energy for the body's cells, which helps to reduce the production of ammonia. Overall, acetates are a useful tool in the treatment of various medical conditions, and their use is closely monitored by healthcare professionals to ensure their safe and effective use.
Coenzyme A (CoA) is a small molecule that plays a crucial role in many metabolic pathways in the body. It is a thiol group (a sulfur-containing molecule) attached to a fatty acid molecule, and it serves as a carrier molecule for fatty acids in the body. In the medical field, CoA is involved in a variety of processes, including the breakdown of carbohydrates, fats, and proteins, as well as the synthesis of lipids and cholesterol. It is also involved in the metabolism of certain drugs and toxins. Disruptions in CoA metabolism can lead to a variety of medical conditions, including fatty acid oxidation disorders, which are a group of rare genetic disorders that affect the body's ability to break down fatty acids for energy. These disorders can cause a range of symptoms, including muscle weakness, developmental delays, and neurological problems. In addition, CoA is also involved in the metabolism of certain vitamins and minerals, such as vitamin B12 and selenium, and deficiencies in these nutrients can also affect CoA metabolism and lead to health problems.
In the medical field, Dicarboxylic Acid Transporters (DATs) are a group of proteins that are responsible for transporting dicarboxylic acids across cell membranes. These acids are a group of organic compounds that contain two carboxyl groups, and they are found in a variety of biological processes, including energy metabolism, neurotransmission, and the synthesis of certain hormones. DATs are located in the plasma membrane of cells and use a facilitated diffusion mechanism to transport dicarboxylic acids across the membrane. This means that they do not require energy to function and simply use the concentration gradient of the dicarboxylic acid to move it across the membrane. There are several different types of DATs, including the sodium-dependent dicarboxylate cotransporter (NaDC) and the proton-dependent dicarboxylate transporter (DICV). These transporters play important roles in the metabolism of dicarboxylic acids in the body and are involved in the regulation of various physiological processes.
Aconitic acid is a dicarboxylic acid that is found naturally in many plants, including hops and walnuts. It is also produced synthetically and has been used in various medical applications. In the medical field, aconitic acid is primarily used as a local anesthetic. It is applied topically to the skin to numb the area and reduce pain. It is also used as a muscle relaxant and to treat muscle spasms. Aconitic acid has also been studied for its potential use in treating certain types of cancer. It has been shown to have anti-tumor effects and may be effective in combination with other cancer treatments. However, aconitic acid can be toxic in high doses and can cause serious side effects, including nausea, vomiting, and cardiac arrhythmias. As a result, it is typically only used under the supervision of a healthcare professional and is not available over-the-counter.
Ranitidine is a medication that is used to treat conditions such as heartburn, acid reflux, and stomach ulcers. It works by reducing the production of stomach acid, which can help to relieve symptoms and promote healing. Ranitidine is available in both over-the-counter and prescription forms, and it is usually taken by mouth. It is generally considered to be safe and effective when used as directed, but it can cause side effects such as headache, dizziness, and constipation. In some cases, ranitidine may interact with other medications or medical conditions, so it is important to talk to a healthcare provider before taking it.
Gallium is a chemical element with the symbol Ga and atomic number 31. It is a soft, silvery-white metal that is used in a variety of medical applications, including: 1. Radiopharmaceuticals: Gallium-67 is a radioactive isotope of gallium that is used in nuclear medicine to diagnose and treat various types of cancer, including Hodgkin's lymphoma, non-Hodgkin's lymphoma, and breast cancer. 2. Imaging agents: Gallium compounds are used as imaging agents in magnetic resonance imaging (MRI) and computed tomography (CT) scans to detect and diagnose various medical conditions, including infections, tumors, and inflammatory diseases. 3. Cancer treatment: Gallium nitrate is a medication that is used to treat certain types of cancer, including multiple myeloma and non-Hodgkin's lymphoma. 4. Wound healing: Gallium nitrate has been shown to promote wound healing by reducing inflammation and increasing blood flow to the affected area. Overall, gallium has a variety of medical applications, and its unique properties make it a valuable tool in the diagnosis and treatment of various medical conditions.
Phosphofructokinase-1 (PFK-1) is an enzyme that plays a critical role in the glycolytic pathway, which is the process by which cells convert glucose into energy. PFK-1 catalyzes the conversion of fructose-6-phosphate (F6P) to fructose-1,6-bisphosphate (F1,6BP) in the presence of ATP. This reaction is a key regulatory step in glycolysis, as it is the first committed step in the pathway and is subject to feedback inhibition by ATP and citrate. PFK-1 is found in the cytosol of most cells and is regulated by a variety of factors, including substrate availability, allosteric effectors, and covalent modification. Allosteric activators of PFK-1 include AMP, fructose-2,6-bisphosphate, and citrate, while allosteric inhibitors include ATP, citrate, and alanine. Covalent modification of PFK-1 by phosphorylation can also regulate its activity. In the medical field, PFK-1 is of interest because it is a potential target for the treatment of a variety of diseases, including diabetes, cancer, and heart disease. For example, drugs that inhibit PFK-1 have been shown to reduce glucose uptake and utilization in cancer cells, making them more susceptible to chemotherapy. Similarly, drugs that activate PFK-1 have been shown to improve glucose tolerance and insulin sensitivity in individuals with type 2 diabetes.
Pyruvates are organic compounds that are produced during the metabolism of carbohydrates in the body. They are the end product of glycolysis, the first stage of cellular respiration, which occurs in the cytoplasm of cells. In the medical field, pyruvates are often used as a source of energy for cells. They can be converted into acetyl-CoA, which enters the citric acid cycle (also known as the Krebs cycle or TCA cycle) and is further metabolized to produce ATP, the primary energy currency of the cell. Pyruvates are also used in the production of certain amino acids, such as alanine and glutamate, and in the synthesis of other important molecules, such as lipids and nucleotides. In some cases, pyruvates can also be converted into lactic acid, which can accumulate in the muscles during periods of intense exercise and contribute to muscle fatigue. This process is known as anaerobic glycolysis. Overall, pyruvates play a critical role in the metabolism of carbohydrates and the production of energy in the body.
In the medical field, purines are a type of organic compound that are found in many foods and are also produced by the body as a natural byproduct of metabolism. Purines are the building blocks of nucleic acids, which are the genetic material in all living cells. They are also important for the production of energy in the body. Purines are classified into two main types: endogenous purines, which are produced by the body, and exogenous purines, which are obtained from the diet. Foods that are high in purines include red meat, organ meats, seafood, and some types of beans and legumes. In some people, the body may not be able to properly break down and eliminate purines, leading to a buildup of uric acid in the blood. This condition, known as gout, can cause pain and inflammation in the joints. High levels of uric acid in the blood can also lead to the formation of kidney stones and other health problems.
In the medical field, "iron" refers to a mineral that is essential for the production of red blood cells, which carry oxygen throughout the body. Iron is also important for the proper functioning of the immune system, metabolism, and energy production. Iron deficiency is a common condition that can lead to anemia, a condition in which the body does not have enough red blood cells to carry oxygen to the body's tissues. Symptoms of iron deficiency anemia may include fatigue, weakness, shortness of breath, and pale skin. Iron supplements are often prescribed to treat iron deficiency anemia, and dietary changes may also be recommended to increase iron intake. However, it is important to note that excessive iron intake can also be harmful, so it is important to follow the recommended dosage and consult with a healthcare provider before taking any iron supplements.
Carboxylic acids are a class of organic compounds that contain a carboxyl functional group (-COOH). In the medical field, carboxylic acids are often used as drugs or as intermediates in the synthesis of drugs. They have a wide range of biological activities and can be used to treat a variety of conditions, including infections, inflammation, and pain. Some examples of carboxylic acids that are used in medicine include aspirin, ibuprofen, and naproxen. These drugs are commonly used to relieve pain, reduce inflammation, and lower fever. Carboxylic acids can also be used to synthesize other drugs, such as antibiotics and anti-cancer agents.
Glucose is a simple sugar that is a primary source of energy for the body's cells. It is also known as blood sugar or dextrose and is produced by the liver and released into the bloodstream by the pancreas. In the medical field, glucose is often measured as part of routine blood tests to monitor blood sugar levels in people with diabetes or those at risk of developing diabetes. High levels of glucose in the blood, also known as hyperglycemia, can lead to a range of health problems, including heart disease, nerve damage, and kidney damage. On the other hand, low levels of glucose in the blood, also known as hypoglycemia, can cause symptoms such as weakness, dizziness, and confusion. In severe cases, it can lead to seizures or loss of consciousness. In addition to its role in energy metabolism, glucose is also used as a diagnostic tool in medical testing, such as in the measurement of blood glucose levels in newborns to detect neonatal hypoglycemia.
Acetyl-CoA carboxylase (ACC) is an enzyme that plays a critical role in the regulation of fatty acid synthesis in the body. It catalyzes the conversion of acetyl-CoA to malonyl-CoA, which is the first committed step in the synthesis of fatty acids from carbohydrates and lipids. In the medical field, ACC is of particular interest because it is a key enzyme in the regulation of energy metabolism and is involved in the development of obesity, type 2 diabetes, and other metabolic disorders. Inhibition of ACC has been proposed as a potential therapeutic strategy for the treatment of these conditions. Additionally, ACC is also involved in the regulation of gluconeogenesis, the process by which the liver produces glucose from non-carbohydrate sources.
Kidney calculi, also known as renal calculi or renal stones, are solid masses made up of minerals and salts that form in the kidneys. They can be as small as a grain of sand or as large as a golf ball, and can cause a range of symptoms, including pain, blood in the urine, and difficulty urinating. Kidney calculi can form when there is an imbalance of minerals and salts in the urine, or when the kidneys are not able to properly remove these substances from the body. They are a common medical condition, and can be treated with a variety of methods, including medication, lifestyle changes, and surgical procedures.
Nephrolithiasis is a medical condition characterized by the formation of stones in the kidneys or urinary tract. These stones can be composed of various materials, including calcium, oxalate, uric acid, cystine, and struvite. The presence of stones can cause a range of symptoms, including pain, blood in the urine, frequent urination, and difficulty urinating. In severe cases, stones can block the flow of urine, leading to kidney damage or infection. Treatment for nephrolithiasis typically involves medications to dissolve the stones or procedures to remove them, such as shock wave lithotripsy or surgery.
Pyruvic acid is a chemical compound that is produced during the metabolism of carbohydrates in the body. It is a key intermediate in the process of cellular respiration, which is the process by which cells convert glucose into energy. Pyruvic acid is produced when glucose is broken down in the cytoplasm of cells through a process called glycolysis. It is then transported into the mitochondria, where it is converted into acetyl-CoA, which is used in the citric acid cycle to produce energy in the form of ATP. Pyruvic acid is also used in the production of certain amino acids and other important compounds in the body. In the medical field, pyruvic acid is sometimes used as a dietary supplement or in the treatment of certain medical conditions, such as lactic acidosis, a condition in which there is an excess of lactic acid in the blood.
Anovulation is a medical condition in which a woman's ovaries do not release an egg (ovulate) during a menstrual cycle. This can occur for a variety of reasons, including hormonal imbalances, structural problems with the ovaries or uterus, or certain medical conditions such as polycystic ovary syndrome (PCOS). Anovulation can make it difficult for a woman to become pregnant, as the egg is necessary for fertilization to occur. It is often diagnosed through a combination of physical examination, blood tests, and imaging studies. Treatment for anovulation depends on the underlying cause and may include medications to regulate hormone levels, lifestyle changes, or assisted reproductive technologies such as in vitro fertilization (IVF).
In the medical field, carbon isotopes are atoms of carbon that have a different number of neutrons than the most common isotope, carbon-12. There are two stable isotopes of carbon, carbon-12 and carbon-13, and several unstable isotopes that are used in medical applications. Carbon-13, in particular, is used in medical imaging techniques such as magnetic resonance spectroscopy (MRS) and positron emission tomography (PET). In MRS, carbon-13 is used to study the metabolism of certain compounds in the body, such as glucose and amino acids. In PET, carbon-13 is used to create images of the body's metabolism by tracing the movement of a radioactive tracer through the body. Carbon-11, another unstable isotope of carbon, is used in PET imaging to study various diseases, including cancer, Alzheimer's disease, and heart disease. Carbon-11 is produced in a cyclotron and then attached to a molecule that is specific to a particular target in the body. The tracer is then injected into the patient and imaged using a PET scanner to detect the location and extent of the disease. Overall, carbon isotopes play an important role in medical imaging and research, allowing doctors and researchers to better understand the functioning of the body and diagnose and treat various diseases.
In the medical field, oxalates are organic compounds that contain the oxalate ion (C2O4^2-). Oxalates are commonly found in many foods, including spinach, beets, and chocolate, as well as in some medications and industrial chemicals. In the body, oxalates can form crystals that can accumulate in various organs, leading to a condition called oxalosis. Oxalosis can cause damage to the kidneys, leading to kidney stones and other kidney problems. It can also cause damage to the bones, leading to a condition called osteomalacia. In some cases, high levels of oxalates in the blood can lead to a condition called primary hyperoxaluria, which is a rare genetic disorder that can cause kidney stones, kidney damage, and other health problems. Overall, oxalates are an important topic in the medical field, particularly in the context of kidney health and the prevention and treatment of kidney stones.
Carbon-sulfur ligases are enzymes that catalyze the formation of carbon-sulfur bonds in organic molecules. These enzymes are important in the biosynthesis of various sulfur-containing compounds, such as cysteine and methionine, which are essential amino acids in proteins. Carbon-sulfur ligases are also involved in the metabolism of sulfur-containing compounds, such as hydrogen sulfide and mercaptans. In the medical field, carbon-sulfur ligases are of interest because they play a role in the development and progression of certain diseases, such as cancer and neurodegenerative disorders. Additionally, carbon-sulfur ligases are being studied as potential targets for the development of new drugs.
Succinates are a class of organic compounds that contain the succinate functional group, which is a dicarboxylic acid with the chemical formula C4H6O4. In the medical field, succinates are often used as intermediates in the production of other chemicals and drugs, as well as in the treatment of certain medical conditions. One of the most well-known succinates in medicine is sodium succinate, which is used as a metabolic intermediate in the production of energy in the body. It is also used as a treatment for certain types of metabolic disorders, such as lactic acidosis, which is a condition characterized by an excess of lactic acid in the blood. Another example of a succinate used in medicine is propofol, which is a sedative and anesthetic medication that is commonly used in hospitals and medical procedures. Propofol is a derivative of the succinate molecule and is used to induce and maintain anesthesia in patients. Overall, succinates play an important role in the medical field as intermediates in the production of other chemicals and drugs, as well as in the treatment of certain medical conditions.
Carboxy-lyases are a class of enzymes that catalyze the cleavage of carbon-carbon bonds in organic molecules. These enzymes typically use a carboxyl group as a leaving group, resulting in the formation of two smaller molecules. Carboxy-lyases are involved in a variety of metabolic pathways, including the breakdown of amino acids, fatty acids, and carbohydrates. They are also involved in the biosynthesis of certain compounds, such as vitamins and hormones. In the medical field, carboxy-lyases are of interest because they play a role in the metabolism of drugs and other xenobiotics, and may be targeted for the development of new therapeutic agents.
In the medical field, dicarboxylic acids are a group of organic compounds that contain two carboxylic acid groups (-COOH) attached to a central carbon atom. These acids are commonly found in the human body and play important roles in various physiological processes. Some examples of dicarboxylic acids include glutaric acid, adipic acid, and suberic acid. Glutaric acid is involved in the metabolism of amino acids and the breakdown of certain drugs. Adipic acid is a building block of adipose tissue and is involved in the regulation of energy metabolism. Suberic acid is a component of certain lipids and has been shown to have anti-inflammatory properties. In some cases, dicarboxylic acids can be present in the blood at abnormally high levels, which can indicate certain medical conditions such as glutaric aciduria type 1 or methylmalonic acidemia. These conditions are rare genetic disorders that affect the metabolism of certain amino acids or fatty acids, leading to the accumulation of dicarboxylic acids in the body.
In the medical field, carrier proteins are proteins that transport molecules across cell membranes or within cells. These proteins bind to specific molecules, such as hormones, nutrients, or waste products, and facilitate their movement across the membrane or within the cell. Carrier proteins play a crucial role in maintaining the proper balance of molecules within cells and between cells. They are involved in a wide range of physiological processes, including nutrient absorption, hormone regulation, and waste elimination. There are several types of carrier proteins, including facilitated diffusion carriers, active transport carriers, and ion channels. Each type of carrier protein has a specific function and mechanism of action. Understanding the role of carrier proteins in the body is important for diagnosing and treating various medical conditions, such as genetic disorders, metabolic disorders, and neurological disorders.
Pyruvate carboxylase (PC) is an enzyme that plays a crucial role in the metabolism of glucose and other carbohydrates in the body. It catalyzes the conversion of pyruvate, a key intermediate in glycolysis, into oxaloacetate, a molecule that can be used in the citric acid cycle (also known as the Krebs cycle or TCA cycle) to generate energy in the form of ATP. PC is a biotin-dependent enzyme that is found in the mitochondria of most cells in the body. It is involved in several metabolic pathways, including gluconeogenesis (the production of glucose from non-carbohydrate sources), the citric acid cycle, and the synthesis of fatty acids and amino acids. In the medical field, PC is of interest because it is involved in several diseases, including diabetes, obesity, and cancer. For example, mutations in the PC gene can cause a rare inherited disorder called pyruvate carboxylase deficiency, which can lead to hypoglycemia (low blood sugar) and other metabolic problems. In addition, PC has been shown to be overexpressed in some types of cancer, and it is being investigated as a potential target for cancer therapy.
In the medical field, glutamates refer to a group of amino acids that are important for various physiological functions in the body. Glutamate is the most abundant amino acid in the human body and is involved in many important processes, including neurotransmission, muscle contraction, and the regulation of blood pressure. In the brain, glutamate is the primary excitatory neurotransmitter, meaning that it stimulates the activity of neurons. However, excessive levels of glutamate can be toxic to neurons and have been implicated in the development of several neurological disorders, including Alzheimer's disease, Parkinson's disease, and epilepsy. Glutamates are also important for the regulation of blood pressure, as they help to relax blood vessels and lower blood pressure. In addition, glutamates play a role in the immune system, as they help to activate immune cells and promote inflammation. Overall, glutamates are a critical component of many physiological processes in the body and are the subject of ongoing research in the medical field.
The Ketoglutarate Dehydrogenase Complex (KGDHC) is an enzyme complex that plays a crucial role in the citric acid cycle, also known as the Krebs cycle or TCA cycle. It is responsible for the oxidation of alpha-ketoglutarate, a molecule produced during the breakdown of amino acids, to succinyl-CoA, a molecule that enters the citric acid cycle. The KGDHC is a large multi-subunit enzyme complex that contains three different subunits: E1, E2, and E3. The E1 subunit catalyzes the oxidation of alpha-ketoglutarate to succinyl-CoA, while the E2 subunit catalyzes the transfer of electrons from the alpha-ketoglutarate to the E3 subunit. The E3 subunit then transfers the electrons to the electron transport chain, which generates ATP, the energy currency of the cell. The KGDHC is an important enzyme complex in the citric acid cycle because it is the first step in the cycle that requires oxygen. It is also a key enzyme in the metabolism of amino acids, as it is involved in the breakdown of glutamate, a major amino acid in the body. Disruptions in the function of the KGDHC can lead to a variety of metabolic disorders, including Leigh syndrome, a rare genetic disorder that affects the brain and muscles.
Urinary calculi, also known as kidney stones, are solid masses that form in the urinary tract. They are composed of various minerals and salts, including calcium, oxalate, uric acid, and cystine. The formation of urinary calculi is a complex process that involves the concentration of minerals and salts in the urine, which can lead to the formation of crystals. These crystals can then grow and clump together to form a stone. Urinary calculi can occur in any part of the urinary tract, including the kidneys, ureters, bladder, and urethra. The size and location of the stone can affect the symptoms experienced by the patient. Symptoms of urinary calculi may include pain in the lower back or abdomen, difficulty urinating, blood in the urine, frequent urination, and nausea or vomiting. Treatment for urinary calculi depends on the size and location of the stone, as well as the patient's overall health. Small stones may pass through the urinary tract on their own, while larger stones may require medical intervention, such as shock wave lithotripsy or surgery.
Fumarate hydratase (FH) is an enzyme that plays a critical role in the metabolism of fumarate, a molecule involved in the citric acid cycle. In the medical field, FH deficiency is a rare genetic disorder that affects the metabolism of fumarate and leads to the accumulation of this molecule in the body. This accumulation can cause a variety of health problems, including kidney disease, high blood pressure, and an increased risk of developing certain types of cancer, such as kidney cancer and ovarian cancer. Treatment for FH deficiency typically involves managing the symptoms of the condition and addressing any complications that arise.
Calcium oxalate is a chemical compound that is commonly found in many plants, including spinach, rhubarb, and beets. In the medical field, calcium oxalate is often associated with kidney stones, which are hard, mineral deposits that can form in the kidneys and cause pain and other symptoms. Calcium oxalate stones are the most common type of kidney stone, accounting for about 75% of all cases. They can also form in the urinary tract and can cause blockages and other complications. In addition to kidney stones, calcium oxalate can also accumulate in the blood and cause other health problems, such as hyperoxaluria, which is a condition characterized by high levels of oxalate in the blood.
Bacterial proteins are proteins that are synthesized by bacteria. They are essential for the survival and function of bacteria, and play a variety of roles in bacterial metabolism, growth, and pathogenicity. Bacterial proteins can be classified into several categories based on their function, including structural proteins, metabolic enzymes, regulatory proteins, and toxins. Structural proteins provide support and shape to the bacterial cell, while metabolic enzymes are involved in the breakdown of nutrients and the synthesis of new molecules. Regulatory proteins control the expression of other genes, and toxins can cause damage to host cells and tissues. Bacterial proteins are of interest in the medical field because they can be used as targets for the development of antibiotics and other antimicrobial agents. They can also be used as diagnostic markers for bacterial infections, and as vaccines to prevent bacterial diseases. Additionally, some bacterial proteins have been shown to have therapeutic potential, such as enzymes that can break down harmful substances in the body or proteins that can stimulate the immune system.
3-Hydroxyacyl CoA dehydrogenases are a group of enzymes that play a crucial role in the metabolism of fatty acids. These enzymes catalyze the oxidation of 3-hydroxyacyl-CoA molecules to their corresponding trans-enoyl-CoA molecules, which is an essential step in the breakdown of fatty acids for energy production. In the medical field, 3-hydroxyacyl CoA dehydrogenases are often studied in the context of metabolic disorders such as diabetes, obesity, and fatty liver disease. Abnormalities in the activity or expression of these enzymes can lead to the accumulation of toxic intermediates in the fatty acid metabolism pathway, which can cause cellular damage and contribute to the development of these diseases. In addition, 3-hydroxyacyl CoA dehydrogenases are also important in the regulation of energy metabolism in the body. They are involved in the control of the citric acid cycle, which is the primary source of energy for the body's cells. Therefore, understanding the function and regulation of these enzymes is important for developing new treatments for metabolic disorders and improving overall health.
Piperazines are a class of organic compounds that contain a six-membered ring with two nitrogen atoms. They are commonly used in the medical field as drugs and are known for their anticholinergic, antispasmodic, and sedative properties. Some examples of piperazine-based drugs include antihistamines, antipsychotics, and antidiarrheals. Piperazines can also be used as intermediates in the synthesis of other drugs.
Ligases are enzymes that catalyze the formation of covalent bonds between two molecules, typically by joining together small molecules such as nucleotides, amino acids, or sugars. In the medical field, ligases play important roles in various biological processes, including DNA replication, transcription, and translation. One example of a ligase enzyme is DNA ligase, which is responsible for joining together the two strands of DNA during replication and repair. Another example is RNA ligase, which is involved in the formation of RNA molecules by joining together RNA nucleotides. Mutations or deficiencies in ligase enzymes can lead to various medical conditions, such as genetic disorders, cancer, and viral infections. For example, mutations in the DNA ligase gene can cause rare inherited disorders such as Cockayne syndrome and Xeroderma pigmentosum, which are characterized by sensitivity to sunlight and an increased risk of cancer. Similarly, mutations in the RNA ligase gene can lead to various forms of cancer, including breast cancer and leukemia.
Magnesium is a mineral that is essential for many bodily functions. It is involved in over 300 enzymatic reactions in the body, including the production of energy, the synthesis of proteins and DNA, and the regulation of muscle and nerve function. In the medical field, magnesium is used to treat a variety of conditions, including: 1. Hypomagnesemia: A deficiency of magnesium in the blood. This can cause symptoms such as muscle cramps, spasms, and seizures. 2. Cardiac arrhythmias: Abnormal heart rhythms that can be caused by low levels of magnesium. 3. Pre-eclampsia: A condition that can occur during pregnancy and is characterized by high blood pressure and protein in the urine. Magnesium supplementation may be used to treat this condition. 4. Chronic kidney disease: Magnesium is often lost in the urine of people with chronic kidney disease, and supplementation may be necessary to maintain adequate levels. 5. Alcohol withdrawal: Magnesium supplementation may be used to treat symptoms of alcohol withdrawal, such as tremors and seizures. 6. Muscle spasms: Magnesium can help to relax muscles and relieve spasms. 7. Anxiety and depression: Some studies have suggested that magnesium supplementation may help to reduce symptoms of anxiety and depression. Magnesium is available in various forms, including oral tablets, capsules, and intravenous solutions. It is important to note that high levels of magnesium can also be toxic, so it is important to use magnesium supplements under the guidance of a healthcare provider.
Acetoin is a chemical compound that is produced during the metabolism of certain types of bacteria, including those found in the gut microbiome. It is also produced during the fermentation of certain types of carbohydrates, such as those found in fruits and vegetables. In the medical field, acetoin has been studied for its potential therapeutic effects. For example, it has been shown to have anti-inflammatory properties and may be useful in the treatment of conditions such as inflammatory bowel disease and rheumatoid arthritis. It has also been studied for its potential to improve insulin sensitivity and reduce the risk of type 2 diabetes. Acetoin is not currently used as a medication, but it is being studied for its potential therapeutic applications. Further research is needed to fully understand its effects and potential uses in medicine.
Edetic acid, also known as ethylenediaminetetraacetic acid (EDTA), is a synthetic organic acid that is commonly used in the medical field as a chelating agent. It is a colorless, water-soluble solid that is used to dissolve minerals and other metal ions in solution. In medicine, EDTA is often used to treat heavy metal poisoning, such as lead or mercury poisoning, by binding to the metal ions and facilitating their excretion from the body. It is also used as an anticoagulant in blood tests and as a component of certain contrast agents used in diagnostic imaging procedures. EDTA is available in various forms, including tablets, capsules, and intravenous solutions. It is generally considered safe when used as directed, but high doses or prolonged use can cause side effects such as nausea, vomiting, and allergic reactions.
Quaternary ammonium compounds (QACs) are a class of cationic compounds that consist of a central nitrogen atom bonded to four alkyl or aryl groups, with one of the alkyl groups replaced by a positively charged ammonium ion. In the medical field, QACs are commonly used as disinfectants, antiseptics, and preservatives due to their broad-spectrum antimicrobial activity against bacteria, viruses, fungi, and algae. QACs work by disrupting the cell membrane of microorganisms, leading to cell lysis and death. They are particularly effective against Gram-positive bacteria, which have a thick peptidoglycan layer that can be penetrated by the positively charged ammonium ion. QACs are also effective against enveloped viruses, such as influenza and herpes, by disrupting the viral envelope. QACs are used in a variety of medical applications, including as disinfectants for surfaces and equipment, antiseptics for skin and wound care, and preservatives for pharmaceuticals and medical devices. However, QACs can also be toxic to humans and other animals if ingested or inhaled in high concentrations. Therefore, proper handling and use of QACs are essential to minimize the risk of adverse effects.
Alkalosis is a medical condition characterized by an increased level of alkaline substances in the blood or other body fluids. This can occur when there is a decrease in the amount of acid in the body, or when there is an increase in the amount of alkaline substances such as bicarbonate ions. There are several types of alkalosis, including respiratory alkalosis, metabolic alkalosis, and mixed alkalosis. Respiratory alkalosis occurs when the body tries to compensate for low levels of carbon dioxide in the blood by breathing more deeply and rapidly, which leads to an increase in the amount of oxygen in the blood and a decrease in the amount of carbon dioxide. Metabolic alkalosis occurs when there is an increase in the production of bicarbonate ions in the body, which can be caused by a variety of factors such as certain medications, kidney disease, or excessive vomiting or diarrhea. Mixed alkalosis occurs when both respiratory and metabolic factors are involved. Symptoms of alkalosis can vary depending on the type and severity of the condition, but may include dizziness, lightheadedness, tingling or numbness in the extremities, muscle cramps, and nausea or vomiting. Treatment for alkalosis typically involves addressing the underlying cause of the condition, such as adjusting breathing patterns or treating the underlying medical condition.
Oxalic acid is a naturally occurring organic acid that is found in many plants and animals. It is also produced industrially as a chemical intermediate in the production of various chemicals and dyes. In the medical field, oxalic acid is sometimes used as a diagnostic tool to help identify certain medical conditions. For example, high levels of oxalic acid in the urine can be a sign of kidney disease or other medical conditions that affect the kidneys. Oxalic acid is also used in some medical treatments, such as the treatment of certain types of kidney stones. In this case, oxalic acid is used to dissolve the stones and help them pass through the urinary tract. However, it is important to note that oxalic acid can also be toxic in high doses and can cause serious health problems if ingested or inhaled. As such, it is important to use oxalic acid with caution and under the guidance of a qualified healthcare professional.
Infertility, female refers to the inability of a woman to conceive a child after a year of regular, unprotected sexual intercourse. This condition can be caused by a variety of factors, including hormonal imbalances, structural abnormalities in the reproductive organs, infections, and lifestyle factors such as smoking, excessive alcohol consumption, and poor nutrition. Infertility can also be caused by age, with fertility declining naturally as a woman gets older. Treatment options for female infertility may include medications to stimulate ovulation, surgery to correct structural abnormalities, assisted reproductive technologies such as in vitro fertilization (IVF), or the use of donor eggs or embryos.
Lactic acid is a naturally occurring organic acid that is produced by the metabolism of glucose in the body. It is a byproduct of the process of glycolysis, which occurs in the cytoplasm of cells when there is not enough oxygen available for complete oxidation of glucose to carbon dioxide and water. In the medical field, lactic acid is often measured in the blood as an indicator of tissue oxygenation and energy metabolism. High levels of lactic acid in the blood can be a sign of tissue hypoxia, which is a lack of oxygen supply to the body's tissues. This can occur in a variety of medical conditions, including sepsis, shock, and certain types of cancer. Lactic acidosis is a condition characterized by high levels of lactic acid in the blood and can be caused by a variety of factors, including liver disease, kidney failure, and certain medications. It can be a serious medical condition and requires prompt treatment. In addition to its role in metabolism and energy production, lactic acid has also been used in various medical treatments, including as a topical antiseptic and as a component of certain medications.
Phosphofructokinases (PFKs) are a family of enzymes that play a critical role in the glycolytic pathway, which is the process by which cells convert glucose into energy. PFKs catalyze the conversion of fructose-6-phosphate (F6P) to fructose-1,6-bisphosphate (F1,6BP) by transferring a phosphate group from ATP to F6P. This reaction is a key regulatory step in glycolysis, as it is the first committed step in the pathway and is subject to feedback inhibition by ATP and citrate. PFKs are found in all cells and tissues, and there are several different isoforms of the enzyme, which are encoded by different genes and are expressed at different levels in different tissues. PFK activity is regulated by a variety of factors, including substrate availability, allosteric effectors, and post-translational modifications such as phosphorylation. In the medical field, PFKs are of interest because they are involved in a number of different diseases and conditions, including diabetes, cancer, and heart disease. For example, mutations in the PFK1 gene, which encodes the muscle-specific isoform of PFK, have been associated with a rare form of diabetes known as PFKM-related diabetes. In addition, PFK activity is often altered in cancer cells, and targeting PFKs has been proposed as a potential therapeutic strategy for cancer treatment.
In the medical field, anions are negatively charged ions that are found in the body fluids, such as blood and urine. They are important for maintaining the balance of electrolytes in the body and play a role in various physiological processes, including nerve function, muscle contraction, and acid-base balance. Anions can be classified into different types based on their chemical composition, such as chloride ions (Cl-), bicarbonate ions (HCO3-), and phosphate ions (PO43-). Each type of anion has a specific function in the body and can be affected by various medical conditions, such as kidney disease, acidosis, and electrolyte imbalances. In some cases, anions can be used as diagnostic markers for certain medical conditions, such as high levels of chloride ions in the blood may indicate dehydration or kidney disease, while low levels of bicarbonate ions may indicate acidosis. Therefore, monitoring the levels of anions in the body fluids is an important part of medical diagnosis and treatment.
Iron radioisotopes are radioactive isotopes of iron that are used in medical imaging and treatment. These isotopes are typically produced by bombarding iron targets with high-energy particles, such as protons or neutrons. The resulting radioisotopes have a short half-life, meaning that they decay quickly and emit radiation that can be detected by medical imaging equipment. Iron radioisotopes are used in a variety of medical applications, including: 1. Diagnostic imaging: Iron radioisotopes can be used to create images of the body's organs and tissues. For example, iron-59 is often used to study the liver and spleen, while iron-62 is used to study the bone marrow. 2. Radiation therapy: Iron radioisotopes can also be used to treat certain types of cancer. For example, iron-59 is used to treat liver cancer, while iron-62 is used to treat multiple myeloma. 3. Research: Iron radioisotopes are also used in research to study the metabolism and distribution of iron in the body. Overall, iron radioisotopes play an important role in the diagnosis and treatment of various medical conditions, and are a valuable tool in the field of nuclear medicine.
Succinic acid is a naturally occurring dicarboxylic acid that is found in many plants and animals. It is also produced industrially as a precursor to other chemicals, such as polyester and nylon. In the medical field, succinic acid is used as a metabolic intermediate in the citric acid cycle, which is a series of chemical reactions that occur in the mitochondria of cells to produce energy. It is also used as a medication to treat certain types of metabolic disorders, such as lactic acidosis, which is a condition characterized by an excess of lactic acid in the blood. Succinic acid is also used as a food additive, as a flavoring agent, and as a preservative. It is generally considered safe for consumption in small amounts, but larger amounts can be harmful and may cause symptoms such as nausea, vomiting, and diarrhea.
Phosphates are a group of inorganic compounds that contain the phosphate ion (PO4^3-). In the medical field, phosphates are often used as a source of phosphorus, which is an essential nutrient for the body. Phosphorus is important for a variety of bodily functions, including bone health, energy production, and nerve function. Phosphates are commonly found in foods such as dairy products, meats, and grains, as well as in some dietary supplements. In the medical field, phosphates are also used as a medication to treat certain conditions, such as hypophosphatemia (low levels of phosphorus in the blood) and hyperphosphatemia (high levels of phosphorus in the blood). Phosphates can also be used as a component of intravenous fluids, as well as in certain types of dialysis solutions for people with kidney disease. In these cases, phosphates are used to help regulate the levels of phosphorus in the body. It is important to note that high levels of phosphorus in the blood can be harmful, and it is important for people with kidney disease to carefully manage their phosphorus intake. In some cases, medications such as phosphate binders may be prescribed to help prevent the absorption of excess phosphorus from the diet.
Lyases are a class of enzymes that catalyze the cleavage of chemical bonds in a molecule, often resulting in the formation of two smaller molecules. They are involved in a variety of metabolic pathways, including the breakdown of amino acids, carbohydrates, and fatty acids. There are several types of lyases, including oxidoreductases, transferases, hydrolases, and ligases. Each type of lyase has a specific mechanism of action and is involved in different metabolic processes. In the medical field, lyases are often studied in the context of disease and drug development. For example, certain lyases are involved in the metabolism of drugs, and changes in the activity of these enzymes can affect the efficacy and toxicity of drugs. Additionally, some lyases are involved in the metabolism of harmful substances, such as toxins and carcinogens, and their activity can be targeted for therapeutic purposes.
NAD stands for nicotinamide adenine dinucleotide, which is a coenzyme found in all living cells. It plays a crucial role in various metabolic processes, including energy production, DNA repair, and regulation of gene expression. In the medical field, NAD is often used as a supplement to support cellular health and improve overall well-being. It is also being studied for its potential therapeutic applications in treating conditions such as depression, anxiety, and chronic pain.
Bicarbonates, also known as bicarbonate ions or HCO3-, are a type of ion found in the blood and other body fluids. They play an important role in regulating the acid-base balance of the body and maintaining the proper pH of the blood. In the medical field, bicarbonate levels are often measured as part of a routine blood test. Abnormal levels of bicarbonate can indicate a variety of medical conditions, including metabolic acidosis (a condition in which the body produces too much acid), metabolic alkalosis (a condition in which the body produces too little acid), and respiratory acidosis (a condition in which the body is not able to remove enough carbon dioxide from the blood). Bicarbonate is also used in medicine to treat certain conditions, such as metabolic acidosis and respiratory acidosis. It is given intravenously (through a vein) or by mouth in the form of a salt, such as sodium bicarbonate.
Fluoroacetates are a group of organic compounds that contain a fluoroacetate functional group. They are commonly found in plants, particularly in the leaves and stems of certain species, and can be toxic to animals, including humans, if ingested. In the medical field, fluoroacetates are primarily used as research tools to study the metabolism and biochemistry of the body. They are also used as antifungal agents and as a treatment for certain types of cancer. However, exposure to fluoroacetates can be dangerous and can cause a range of symptoms, including nausea, vomiting, abdominal pain, muscle weakness, and in severe cases, seizures, coma, and death. Therefore, it is important to handle fluoroacetates with caution and to seek medical attention immediately if exposure occurs.
Acetoacetates are a group of organic compounds that contain the functional group -COOCH3. They are formed as intermediates in the metabolism of fatty acids and are involved in the production of ketone bodies, which are used as a source of energy by the liver and other tissues in the body. In the medical field, acetoacetates are often used as a diagnostic tool to measure the body's ability to produce ketone bodies, which can be an indicator of certain medical conditions such as diabetes, liver disease, and certain types of cancer. They are also used as a precursor in the synthesis of other compounds, such as acetoacetic esters, which have applications in the pharmaceutical industry.
Organic anion transporters (OATs) are a group of membrane proteins that play a crucial role in the transport of organic anions across cell membranes. These transporters are found in various tissues and organs throughout the body, including the liver, kidney, and brain. OATs are responsible for the uptake and elimination of a wide range of organic anions, including drugs, toxins, and endogenous compounds such as bile acids and neurotransmitters. They are also involved in the regulation of electrolyte balance and the maintenance of acid-base homeostasis. There are several subtypes of OATs, including OAT1, OAT2, OAT3, and OAT4. Each subtype has a distinct tissue distribution and substrate specificity, and they can interact with a variety of drugs and other compounds. In the medical field, OATs are of particular interest because they play a critical role in the disposition of many drugs. Understanding the function and regulation of OATs can help to predict drug-drug interactions, optimize drug dosing, and develop new drugs with improved pharmacokinetic properties. Additionally, OATs have been implicated in the pathophysiology of several diseases, including liver and kidney disease, and may be potential targets for therapeutic intervention.
Fatty acids are organic compounds that are composed of a long chain of carbon atoms with hydrogen atoms attached to them. They are a type of lipid, which are molecules that are insoluble in water but soluble in organic solvents. Fatty acids are an important source of energy for the body and are also used to synthesize other important molecules, such as hormones and cell membranes. In the medical field, fatty acids are often studied in relation to their role in various diseases, such as cardiovascular disease, diabetes, and obesity. They are also used in the development of new drugs and therapies.
Diethylcarbamazine (DEC) is an antischistosomal medication used to treat various types of parasitic infections, including schistosomiasis (bilharzia), filariasis, and onchocerciasis (river blindness). It works by paralyzing the parasites, which are then eliminated from the body through the urine. DEC is typically administered orally in tablet form, and the dosage and duration of treatment depend on the specific parasite being targeted and the severity of the infection. DEC is generally well-tolerated, but side effects may include nausea, vomiting, abdominal pain, and skin rash. In addition to its use as an antischistosomal medication, DEC has also been used as a larvicide to control mosquito populations and prevent the spread of mosquito-borne diseases such as malaria and dengue fever.
Adenosine triphosphate (ATP) is a molecule that serves as the primary energy currency in living cells. It is composed of three phosphate groups attached to a ribose sugar and an adenine base. In the medical field, ATP is essential for many cellular processes, including muscle contraction, nerve impulse transmission, and the synthesis of macromolecules such as proteins and nucleic acids. ATP is produced through cellular respiration, which involves the breakdown of glucose and other molecules to release energy that is stored in the bonds of ATP. Disruptions in ATP production or utilization can lead to a variety of medical conditions, including muscle weakness, fatigue, and neurological disorders. In addition, ATP is often used as a diagnostic tool in medical testing, as levels of ATP can be measured in various bodily fluids and tissues to assess cellular health and function.
In the medical field, "Burns, Chemical" refers to a type of burn that occurs when a person comes into contact with a chemical substance that causes damage to the skin, eyes, or respiratory system. Chemical burns can be caused by a wide range of substances, including acids, alkalis, solvents, and other toxic chemicals. The severity of a chemical burn depends on several factors, including the type and concentration of the chemical, the duration of exposure, and the area of the body affected. Chemical burns can cause immediate pain, redness, swelling, and blistering of the skin, and may also lead to more serious complications if not treated promptly and appropriately. Treatment for chemical burns typically involves removing the chemical from the skin as quickly as possible, washing the affected area with copious amounts of water, and applying a neutralizing agent to neutralize any remaining chemical. In more severe cases, medical attention may be required to manage pain, prevent infection, and treat any systemic effects of the chemical exposure.
In the medical field, glutarates refer to compounds that contain the -COO- functional group, also known as a carboxylate group, attached to a glutaric acid molecule. Glutaric acid is a six-carbon dicarboxylic acid that is naturally produced in the body and is involved in various metabolic processes. Glutarates can be found in a variety of biological molecules, including proteins, lipids, and nucleic acids. They can also be synthesized artificially and used in a variety of applications, such as in the production of plastics, dyes, and pharmaceuticals. In medicine, glutarates have been studied for their potential therapeutic effects in a number of conditions, including neurodegenerative diseases, cancer, and metabolic disorders. For example, some glutarates have been shown to have antioxidant properties and may help protect against oxidative stress and inflammation. Other glutarates have been shown to have anti-cancer effects by inhibiting the growth and proliferation of cancer cells.
Hexosephosphates are a group of compounds that contain a hexose sugar (a sugar with six carbon atoms) and a phosphate group. In the medical field, hexosephosphates are often used as markers of bone metabolism and can be measured in the blood to diagnose and monitor conditions such as osteoporosis, Paget's disease, and bone tumors. They are also used as markers of liver function and can be elevated in liver disease. Hexosephosphates are produced by the breakdown of glycogen and other carbohydrates in the body and are involved in various metabolic processes.
Acidosis is a medical condition characterized by an excess of acid in the blood or other body fluids. This can occur when the body is unable to properly regulate the acid-base balance, leading to an increase in the concentration of hydrogen ions (H+) in the blood. Acidosis can be classified into two main types: respiratory acidosis and metabolic acidosis. Respiratory acidosis occurs when the body is unable to remove enough carbon dioxide (CO2) from the blood, leading to an increase in H+ concentration. Metabolic acidosis, on the other hand, occurs when the body produces too much acid or not enough base to neutralize it, leading to an increase in H+ concentration. Acidosis can have a range of symptoms, depending on the severity and underlying cause. These may include shortness of breath, confusion, dizziness, nausea, vomiting, and muscle weakness. In severe cases, acidosis can lead to organ damage and even death if left untreated. Treatment for acidosis typically involves addressing the underlying cause and managing symptoms as needed.
L-Lactate Dehydrogenase (LDH) is an enzyme that plays a crucial role in the metabolism of lactate, a byproduct of cellular respiration. In the medical field, LDH is often used as a diagnostic marker for various diseases and conditions, including liver and heart diseases, cancer, and muscle injuries. LDH is found in many tissues throughout the body, including the liver, heart, muscles, kidneys, and red blood cells. When these tissues are damaged or injured, LDH is released into the bloodstream, which can be detected through blood tests. In addition to its diagnostic use, LDH is also used as a prognostic marker in certain diseases, such as cancer. High levels of LDH in the blood can indicate a more aggressive form of cancer or a poorer prognosis for the patient. Overall, LDH is an important enzyme in the body's metabolism and plays a critical role in the diagnosis and management of various medical conditions.
Erectile dysfunction (ED) is a medical condition in which a man is unable to achieve or maintain an erection sufficient for sexual activity. It is also known as impotence. ED can be caused by a variety of factors, including physical, psychological, and lifestyle factors. Physical causes of ED may include conditions such as diabetes, high blood pressure, and heart disease. Psychological causes may include stress, anxiety, and depression. Lifestyle factors such as smoking, excessive alcohol consumption, and a sedentary lifestyle can also contribute to ED. Treatment for ED may include lifestyle changes, medications, and in some cases, surgery.
Transferrin is a plasma protein that plays a crucial role in the transport of iron in the bloodstream. It is synthesized in the liver and transported to the bone marrow, where it helps to regulate the production of red blood cells. Transferrin also plays a role in the immune system by binding to and transporting iron to immune cells, where it is used to produce antibodies. In the medical field, low levels of transferrin can be a sign of iron deficiency anemia, while high levels may indicate an excess of iron in the body.
Gluconates are a class of organic compounds that are derived from glucose. They are commonly used in the medical field as electrolyte replenishers, particularly in the treatment of hyponatremia (low sodium levels in the blood) and other electrolyte imbalances. Gluconates are also used as a source of energy for the body and as a chelating agent to remove heavy metals from the body. In addition, some gluconates, such as calcium gluconate, are used as a dietary supplement to increase calcium levels in the body.
Eye burns refer to injuries or damage to the eye caused by exposure to a harmful substance or heat. These burns can range from mild to severe and can cause a variety of symptoms, including pain, redness, tearing, sensitivity to light, and vision loss. Eye burns can be caused by a variety of factors, including chemical burns from exposure to acids, bases, or other chemicals, thermal burns from exposure to heat or flames, and radiation burns from exposure to ultraviolet or infrared radiation. Treatment for eye burns depends on the severity of the injury and the specific cause of the burn. In some cases, simple measures such as washing the eye with cool water or applying a cold compress may be sufficient. In more severe cases, medical treatment may be necessary, including the use of prescription medications, surgery, or other interventions. It is important to seek medical attention immediately if you suspect that you or someone else has suffered an eye burn.
DNA, Bacterial refers to the genetic material of bacteria, which is a type of single-celled microorganism that can be found in various environments, including soil, water, and the human body. Bacterial DNA is typically circular in shape and contains genes that encode for the proteins necessary for the bacteria to survive and reproduce. In the medical field, bacterial DNA is often studied as a means of identifying and diagnosing bacterial infections. Bacterial DNA can be extracted from samples such as blood, urine, or sputum and analyzed using techniques such as polymerase chain reaction (PCR) or DNA sequencing. This information can be used to identify the specific type of bacteria causing an infection and to determine the most effective treatment. Bacterial DNA can also be used in research to study the evolution and diversity of bacteria, as well as their interactions with other organisms and the environment. Additionally, bacterial DNA can be modified or manipulated to create genetically engineered bacteria with specific properties, such as the ability to produce certain drugs or to degrade pollutants.
Polycystic Ovary Syndrome (PCOS) is a common hormonal disorder that affects women of reproductive age. It is characterized by the presence of multiple small cysts on the ovaries, hormonal imbalances, and irregular menstrual cycles. PCOS can cause a range of symptoms, including acne, excessive hair growth, weight gain, infertility, and an increased risk of developing type 2 diabetes and cardiovascular disease. The exact cause of PCOS is not fully understood, but it is believed to be related to genetic and environmental factors. Diagnosis of PCOS typically involves a physical examination, blood tests to measure hormone levels, and imaging studies such as ultrasound. Treatment for PCOS may include lifestyle changes such as weight loss, exercise, and dietary modifications, as well as medications to regulate menstrual cycles, reduce androgen levels, and improve insulin sensitivity. In some cases, fertility treatments may be necessary to help women with PCOS conceive.
Fumarates are organic compounds that contain the functional group -COO-. They are named after the chemical compound fumaric acid, which is a dicarboxylic acid with the formula C4H4O4. Fumarates are commonly used in the medical field as drugs to treat various conditions, including: 1. Hyperkalemia: Fumarates are used to treat high levels of potassium in the blood (hyperkalemia) by increasing the excretion of potassium in the urine. 2. Heart failure: Fumarates are used to treat heart failure by improving the function of the heart muscle and reducing the workload on the heart. 3. Gout: Fumarates are used to treat gout by reducing the production of uric acid in the body. 4. Cancer: Fumarates are being studied as potential cancer treatments due to their ability to inhibit the growth of cancer cells. 5. Inflammatory bowel disease: Fumarates are being studied as potential treatments for inflammatory bowel disease (IBD) by reducing inflammation in the gut. Some examples of fumarate drugs include fumaric acid esters (FAEs), which are used to treat psoriasis and multiple sclerosis, and dimethyl fumarate (DMF), which is used to treat relapsing-remitting multiple sclerosis.
Plutonium is a radioactive element that is not naturally occurring in the environment. It is a synthetic element that is produced in nuclear reactors and is used as a fuel in nuclear weapons and as a component in nuclear power plants. In the medical field, plutonium has been studied for its potential use in cancer treatment. It has been shown to be effective in killing cancer cells, but it is also highly toxic and can cause serious health problems if not handled properly. As a result, the use of plutonium in medicine is limited and is only done in specialized research settings under strict safety protocols.
In the medical field, tartrates refer to compounds that contain the ionized form of the acid tartrate. Tartrates are commonly found in foods such as grapes, wine, and cheese, and are also used in the production of certain medications and dietary supplements. One common use of tartrates in medicine is in the treatment of gout, a type of arthritis caused by the buildup of uric acid crystals in the joints. Tartrates, such as potassium bitartrate, can help to lower the levels of uric acid in the blood and reduce the risk of gout attacks. Tartrates may also be used in the treatment of other conditions, such as high blood pressure and heart disease. For example, calcium tartrate is sometimes used as a calcium supplement to help prevent osteoporosis, a condition in which the bones become weak and brittle. It is important to note that tartrates can interact with other medications and may not be suitable for everyone. If you are considering taking a tartrate-containing supplement or medication, it is important to speak with your healthcare provider first to determine if it is safe and appropriate for you.
In the medical field, organometallic compounds are compounds that contain a metal atom bonded to a carbon atom of an organic molecule. These compounds have a wide range of applications in medicine, including as drugs, diagnostic agents, and catalysts for various chemical reactions. One example of an organometallic compound used in medicine is cisplatin, which is a chemotherapy drug used to treat various types of cancer. Cisplatin contains a platinum atom bonded to two carbon atoms from organic molecules, and its mechanism of action involves binding to DNA and inhibiting its replication. Another example is ferrocene, which is an organometallic compound containing a ferrocene moiety. Ferrocene has been studied for its potential as a treatment for various diseases, including cancer and Alzheimer's disease, due to its ability to modulate cellular signaling pathways. Overall, organometallic compounds have a significant impact on the medical field, and ongoing research is exploring their potential for new therapeutic applications.
In the medical field, a multienzyme complex is a group of two or more enzymes that are physically and functionally linked together to form a single, larger enzyme complex. These complexes can work together to catalyze a series of sequential reactions, or they can work in parallel to carry out multiple reactions simultaneously. Multienzyme complexes are found in a variety of biological processes, including metabolism, DNA replication and repair, and signal transduction. They can be found in both prokaryotic and eukaryotic cells, and they can be composed of enzymes from different cellular compartments. One example of a multienzyme complex is the 2-oxoglutarate dehydrogenase complex, which is involved in the citric acid cycle and the metabolism of amino acids. This complex consists of three enzymes that work together to catalyze the conversion of 2-oxoglutarate to succinyl-CoA. Multienzyme complexes can have important implications for human health. For example, mutations in genes encoding enzymes in these complexes can lead to metabolic disorders, such as maple syrup urine disease and glutaric acidemia type II. Additionally, some drugs target specific enzymes in multienzyme complexes as a way to treat certain diseases, such as cancer.
Urolithiasis is a medical condition characterized by the formation of stones or calculi in the urinary tract. These stones can form in any part of the urinary system, including the kidneys, ureters, bladder, and urethra. The stones can be composed of various materials, including calcium oxalate, calcium phosphate, uric acid, cystine, and struvite. The size and location of the stones can vary, and they can cause a range of symptoms, including pain, blood in the urine, difficulty urinating, and frequent urination. Urolithiasis can be treated with a variety of methods, depending on the size and location of the stones, as well as the patient's overall health. Treatment options may include medications to dissolve the stones, shock wave lithotripsy to break up the stones, or surgery to remove them. Prevention strategies may include maintaining proper hydration, limiting certain foods and drinks that can increase the risk of stone formation, and taking medications to prevent stone formation.
Magnesium compounds are a group of minerals that are essential for various bodily functions. In the medical field, magnesium compounds are often used to treat a variety of conditions, including: 1. Muscle cramps: Magnesium is important for muscle function, and taking magnesium supplements can help prevent and treat muscle cramps. 2. Heart disease: Magnesium can help regulate blood pressure and prevent the formation of blood clots, which can lead to heart attacks and strokes. 3. Osteoporosis: Magnesium is important for bone health, and taking magnesium supplements can help prevent osteoporosis and reduce the risk of fractures. 4. Anxiety and depression: Magnesium has been shown to have a calming effect on the nervous system, and taking magnesium supplements may help reduce symptoms of anxiety and depression. 5. Diabetes: Magnesium can help regulate blood sugar levels and improve insulin sensitivity, which can be beneficial for people with diabetes. Magnesium compounds are available in various forms, including magnesium oxide, magnesium citrate, and magnesium chloride. It is important to consult with a healthcare provider before taking magnesium supplements, as high doses can be harmful and interact with other medications.
Fructosephosphates are compounds that are formed when fructose (a type of sugar) reacts with phosphate ions. They are commonly found in the body and are involved in various metabolic processes, including energy production and the regulation of blood sugar levels. In the medical field, fructosephosphates are often used as a diagnostic tool to assess liver function. Elevated levels of fructosephosphates in the blood can indicate liver damage or disease, such as non-alcoholic fatty liver disease or liver cirrhosis. They may also be used to monitor the effectiveness of treatment for these conditions. Fructosephosphates are also used in some medical treatments, such as the treatment of certain types of cancer. They have been shown to have anti-cancer properties and may help to slow the growth of cancer cells.
Hexosephosphates are a group of compounds that consist of a hexose sugar (such as glucose, fructose, or galactose) attached to a phosphate group. In the medical field, hexosephosphates are often used as markers for certain diseases or conditions, such as diabetes or liver disease. They can also be used as diagnostic tools to help identify and monitor certain types of cancer, such as osteosarcoma or Ewing's sarcoma. Hexosephosphates are produced by the body as a result of certain metabolic processes, and their levels in the blood can provide important information about a person's overall health and well-being.
Malonyl Coenzyme A (Malonyl-CoA) is a molecule that plays a crucial role in fatty acid metabolism. It is synthesized from acetyl-CoA and malate, and is involved in the regulation of fatty acid synthesis and breakdown. Malonyl-CoA is also a key molecule in the process of gluconeogenesis, which is the production of glucose from non-carbohydrate sources. In the medical field, Malonyl-CoA is often studied in relation to metabolic disorders such as obesity, diabetes, and cardiovascular disease.
Diacetyl is a chemical compound that is commonly used as a flavoring agent in the food and beverage industry. It is a colorless, odorless liquid that has a buttery, popcorn-like flavor. In the medical field, diacetyl has been associated with the development of a lung disease called bronchiolitis obliterans, which is also known as "popcorn lung." This condition is caused by inhaling high levels of diacetyl or other related compounds, such as acetoin, which are often used in the production of artificial butter flavorings. People who work in the food and beverage industry, particularly those who handle or inhale these flavorings, are at risk of developing popcorn lung. The disease can cause inflammation and scarring of the small airways in the lungs, leading to difficulty breathing and other respiratory symptoms.
Senna Extract is a natural laxative derived from the plant Cassia senna, which is commonly used in traditional medicine to treat constipation. It works by stimulating the muscles in the intestines to contract, which helps to move stool through the digestive tract. Senna extract is available in various forms, including tablets, capsules, and liquid extracts. It is generally considered safe when used as directed, but it can cause side effects such as cramping, diarrhea, and dehydration if taken in large amounts or for prolonged periods of time. It is important to consult a healthcare professional before using senna extract, especially if you have any underlying medical conditions or are taking other medications.
Sodium is an essential mineral that plays a crucial role in various bodily functions. In the medical field, sodium is often measured in the blood and urine to assess its levels and monitor its balance in the body. Sodium is primarily responsible for regulating the body's fluid balance, which is essential for maintaining blood pressure and proper functioning of the heart, kidneys, and other organs. Sodium is also involved in nerve impulse transmission, muscle contraction, and the production of stomach acid. Abnormal levels of sodium in the body can lead to various medical conditions, including hyponatremia (low sodium levels), hypernatremia (high sodium levels), and dehydration. Sodium levels can be affected by various factors, including diet, medications, and underlying medical conditions. In the medical field, sodium levels are typically measured using a blood test called a serum sodium test or a urine test called a urine sodium test. These tests can help diagnose and monitor various medical conditions related to sodium levels, such as kidney disease, heart failure, and electrolyte imbalances.
Heparin is a medication that is used to prevent and treat blood clots. It is a natural anticoagulant that works by inhibiting the activity of enzymes that are involved in the formation of blood clots. Heparin is typically administered intravenously, but it can also be given by injection or applied topically to the skin. It is commonly used to prevent blood clots in people who are at risk due to surgery, pregnancy, or other medical conditions. Heparin is also used to treat blood clots that have already formed, such as deep vein thrombosis (DVT) and pulmonary embolism (PE). It is important to note that heparin can have serious side effects, including bleeding, and should only be used under the supervision of a healthcare professional.
Medullary sponge kidney is a rare congenital disorder characterized by the presence of multiple cystic dilations in the medulla of the kidney. These cysts are lined by simple cuboidal epithelium and are filled with clear fluid. The cysts are usually located in the papillary region of the kidney and can vary in size and number. The exact cause of medullary sponge kidney is not known, but it is believed to be due to a developmental abnormality during fetal kidney development. The condition is usually diagnosed in adulthood, and symptoms may include recurrent kidney stones, blood in the urine, and abdominal pain. Medullary sponge kidney is typically a benign condition, but it can increase the risk of developing kidney stones and kidney damage. Treatment may involve medications to prevent kidney stones, such as citrate supplements, and in severe cases, surgery may be necessary to remove the affected kidney or cysts.
The Pyruvate Dehydrogenase Complex (PDC) is a multi-enzyme complex that plays a critical role in cellular metabolism. It is located in the mitochondrial matrix and is responsible for converting pyruvate, a three-carbon compound produced during glycolysis, into acetyl-CoA, a two-carbon compound that enters the citric acid cycle (also known as the Krebs cycle or TCA cycle). The PDC is composed of five enzymes: pyruvate dehydrogenase (E1), dihydrolipoyl transacetylase (E2), dihydrolipoyl dehydrogenase (E3), and three accessory enzymes: dihydrolipoyl succinyltransferase (E4), dihydrolipoyl dehydrogenase (E3), and lipoamide synthase (E3). Together, these enzymes work in a coordinated manner to catalyze the oxidative decarboxylation of pyruvate, the transfer of the acetyl group to CoA, and the regeneration of the lipoyl groups that are essential for the activity of the complex. The PDC is a key regulatory enzyme in cellular metabolism, as its activity is tightly controlled by a variety of factors, including the levels of ATP, NADH, and acetyl-CoA. In addition, the PDC is a target for several drugs and toxins, including dichloroacetate, which is used to treat lactic acidosis, and certain organophosphate insecticides, which can inhibit the activity of the complex.
Malonates are organic compounds that contain a malonic acid group (-COOCH2COOH). They are commonly used in the medical field as chelating agents to remove heavy metals from the body. Malonates can also be used as antioxidants and anti-inflammatory agents. One specific malonate, succimer, is used to treat lead poisoning in children. Another malonate, calcium disodium ethylenediaminetetraacetate (CaNa2EDTA), is used to treat heavy metal poisoning, including mercury, lead, and arsenic.
Bisacodyl is a medication that is used to treat constipation. It is a stimulant laxative that works by increasing the movement of muscles in the intestines, which helps to move stool through the digestive system more quickly. Bisacodyl is available in a variety of forms, including tablets, suppositories, and enemas. It is usually taken as needed, but the dosage and frequency of use will depend on the individual's specific condition and the severity of their constipation. It is important to follow the instructions provided by your healthcare provider and to use bisacodyl only as directed.
Butanones, also known as methyl ethyl ketone (MEK) and butyl acetate, are organic compounds that are commonly used in the medical field as solvents and as ingredients in various medical products. MEK is a colorless liquid with a sweet, fruity odor that is used as a solvent in the production of pharmaceuticals, cosmetics, and other medical products. It is also used as a cleaning agent and as a solvent for removing paint and other coatings. Butyl acetate is a colorless liquid with a sweet, fruity odor that is used as a solvent in the production of pharmaceuticals, cosmetics, and other medical products. It is also used as a flavoring agent in food and beverages. Both MEK and butyl acetate are considered to be relatively safe when used in the proper concentrations and under controlled conditions. However, exposure to high concentrations of these compounds can cause irritation of the eyes, nose, and throat, as well as headaches, dizziness, and nausea. In some cases, prolonged or repeated exposure to these compounds may also cause more serious health effects, such as liver and kidney damage.
Adenine nucleotides are a type of nucleotide that contains the nitrogenous base adenine (A) and a sugar-phosphate backbone. They are important molecules in the cell and play a crucial role in various biological processes, including energy metabolism and DNA synthesis. There are three types of adenine nucleotides: adenosine monophosphate (AMP), adenosine diphosphate (ADP), and adenosine triphosphate (ATP). AMP is the simplest form of adenine nucleotide, with only one phosphate group attached to the sugar. ADP has two phosphate groups attached to the sugar, while ATP has three phosphate groups. ATP is often referred to as the "energy currency" of the cell because it stores and releases energy through the transfer of phosphate groups. When ATP is broken down, one of its phosphate groups is released, releasing energy that can be used by the cell for various processes. When ATP is synthesized, energy is required to attach a new phosphate group to the molecule. Adenine nucleotides are involved in many cellular processes, including muscle contraction, nerve impulse transmission, and the synthesis of proteins and nucleic acids. They are also important in the regulation of gene expression and the maintenance of cellular homeostasis.
In the medical field, starvation refers to a severe lack of nutrition and energy due to a prolonged period of not eating enough food. Starvation can occur as a result of various factors, including malnutrition, illness, and intentional fasting. The body requires a certain amount of nutrients, including carbohydrates, proteins, fats, vitamins, and minerals, to function properly. When a person does not consume enough of these nutrients, the body begins to break down its own tissues, including muscle and fat, to provide energy. This can lead to a range of symptoms, including weakness, fatigue, dizziness, and weight loss. In severe cases of starvation, the body may also experience more serious complications, such as organ failure, electrolyte imbalances, and even death. Treatment for starvation typically involves providing adequate nutrition and hydration, as well as addressing any underlying medical conditions that may have contributed to the starvation.
Sodium bicarbonate, also known as baking soda, is a chemical compound with the formula NaHCO3. It is a white, crystalline powder that is commonly used in cooking and baking as a leavening agent. In the medical field, sodium bicarbonate is used as an antacid to neutralize stomach acid and relieve heartburn and indigestion. It is also used to treat metabolic acidosis, a condition in which the body produces too much acid, and to alkalinize the urine in certain medical conditions. In addition, sodium bicarbonate is used in some emergency situations, such as treating severe acidosis or as an antidote for certain types of poisonings.
Clarithromycin is an antibiotic medication that is used to treat a variety of bacterial infections, including pneumonia, bronchitis, skin infections, and ear infections. It is a macrolide antibiotic, which means that it works by inhibiting the growth of bacteria by interfering with their ability to make proteins. Clarithromycin is available in both oral and intravenous forms and is typically taken for a duration of 7 to 14 days, depending on the specific infection being treated. It is important to note that clarithromycin may not be effective against all types of bacteria and that it can have side effects, including nausea, diarrhea, and stomach pain.
Calcium is a chemical element with the symbol Ca and atomic number 20. It is a vital mineral for the human body and is essential for many bodily functions, including bone health, muscle function, nerve transmission, and blood clotting. In the medical field, calcium is often used to diagnose and treat conditions related to calcium deficiency or excess. For example, low levels of calcium in the blood (hypocalcemia) can cause muscle cramps, numbness, and tingling, while high levels (hypercalcemia) can lead to kidney stones, bone loss, and other complications. Calcium supplements are often prescribed to people who are at risk of developing calcium deficiency, such as older adults, vegetarians, and people with certain medical conditions. However, it is important to note that excessive calcium intake can also be harmful, and it is important to follow recommended dosages and consult with a healthcare provider before taking any supplements.
Calcium chloride is a salt that is commonly used in the medical field as a medication and a dietary supplement. It is a white, crystalline powder that is highly soluble in water and is used to increase the concentration of calcium in the blood and to treat certain medical conditions. In the medical field, calcium chloride is used to treat hypocalcemia, which is a condition in which the blood calcium level is too low. It is also used to treat eclampsia, which is a serious complication of pregnancy that can cause seizures and other symptoms. Calcium chloride is also used to treat certain types of heart rhythm disorders, such as atrial fibrillation. Calcium chloride is available as a dietary supplement and can be taken by mouth to increase the body's calcium levels. It is also used as a food additive and is used to preserve food and to enhance the flavor of certain foods. However, it is important to note that calcium chloride should only be taken under the guidance of a healthcare professional, as it can have side effects and may interact with other medications.
Fructosediphosphates (FDPs) are a group of compounds that are formed when fructose (a type of sugar) is broken down by the body. They are found in the blood and urine of people with diabetes, and are often used as a diagnostic tool to help diagnose and monitor the condition. FDPs are also used as a source of energy for the body, and are involved in the metabolism of carbohydrates. In the medical field, FDPs are often measured as part of a routine blood test to help diagnose and manage diabetes.
In the medical field, the term "carbon" typically refers to the chemical element with the atomic number 6, which is a vital component of all living organisms. Carbon is the building block of organic molecules, including proteins, carbohydrates, lipids, and nucleic acids, which are essential for the structure and function of cells and tissues. In medicine, carbon is also used in various diagnostic and therapeutic applications. For example, carbon-13 (13C) is a stable isotope of carbon that is used in metabolic studies to investigate the function of enzymes and pathways in the body. Carbon-14 (14C) is a radioactive isotope of carbon that is used in radiocarbon dating to determine the age of organic materials, including human remains. Additionally, carbon dioxide (CO2) is a gas that is produced by the body during respiration and is exhaled. It is also used in medical applications, such as in carbon dioxide laser therapy, which uses the energy of CO2 lasers to treat various medical conditions, including skin disorders, tumors, and eye diseases.
Ketone bodies are organic compounds that are produced by the liver when there is a lack of glucose available for energy production. They are formed from acetyl-CoA, which is a byproduct of fatty acid metabolism. The three main types of ketone bodies are acetoacetate, beta-hydroxybutyrate, and acetone. Ketone bodies are an important source of energy for the brain and other tissues when glucose is not available. They are also used by the liver to produce glucose through a process called gluconeogenesis. In normal physiological conditions, the body produces small amounts of ketone bodies. However, in certain medical conditions such as diabetes, starvation, or prolonged fasting, the production of ketone bodies increases significantly. High levels of ketone bodies in the blood can lead to a condition called ketosis, which can cause symptoms such as fruity breath odor, nausea, vomiting, and confusion. In summary, ketone bodies are organic compounds produced by the liver in response to a lack of glucose and are an important source of energy for the body.
Hydroxybutyrates are a class of compounds that contain a hydroxybutyrate functional group. They are commonly used in the medical field as medications to treat a variety of conditions, including epilepsy, anxiety, and depression. Some examples of hydroxybutyrates include valproic acid, which is used to treat epilepsy and bipolar disorder, and diazepam, which is used to treat anxiety and seizures. Hydroxybutyrates are also used as dietary supplements to promote muscle growth and improve athletic performance.
Sodium acetate is a chemical compound that is commonly used in the medical field as a buffer solution, an electrolyte, and a laxative. It is a white, crystalline solid that is soluble in water and has a slightly salty taste. In medicine, sodium acetate is often used as a buffer solution to maintain the pH of bodily fluids, such as blood and urine. It is also used as an electrolyte to replace lost minerals in the body, particularly in cases of diarrhea or vomiting. Sodium acetate is also used as a laxative to treat constipation, particularly in patients who are unable to take other forms of laxatives. Sodium acetate is available in various forms, including tablets, capsules, and powders, and is typically prescribed by a healthcare professional. It is generally considered safe when used as directed, but like all medications, it can cause side effects in some people. These may include nausea, vomiting, abdominal pain, and diarrhea.
In the medical field, carbon dioxide (CO2) is a gas that is produced as a byproduct of cellular respiration and is exhaled by the body. It is also used in medical applications such as carbon dioxide insufflation during colonoscopy and laparoscopic surgery, and as a component of medical gases used in anesthesia and respiratory therapy. High levels of CO2 in the blood (hypercapnia) can be a sign of respiratory or metabolic disorders, while low levels (hypocapnia) can be caused by respiratory failure or metabolic alkalosis.
Acyl Coenzyme A (acyl-CoA) is a molecule that plays a central role in metabolism. It is formed when an acyl group (a fatty acid or other long-chain hydrocarbon) is attached to the coenzyme A molecule, which is a small molecule that contains a thiol (-SH) group. Acyl-CoA molecules are involved in a variety of metabolic processes, including the breakdown of fatty acids (beta-oxidation), the synthesis of fatty acids (fatty acid synthesis), and the synthesis of other important molecules such as cholesterol and ketone bodies. In the medical field, acyl-CoA is often measured as a way to assess the activity of certain metabolic pathways, and imbalances in acyl-CoA levels can be associated with a variety of diseases and disorders.
Sodium hydroxide is a chemical compound with the formula NaOH. It is commonly known as lye and is a strong base that is used in various industrial and laboratory applications. In the medical field, sodium hydroxide is not commonly used. However, it can be used in some laboratory procedures to neutralize acidic solutions or to prepare buffer solutions. It is important to handle sodium hydroxide with caution as it is highly caustic and can cause severe burns if it comes into contact with skin or eyes.
Amino acids are organic compounds that are the building blocks of proteins. They are composed of an amino group (-NH2), a carboxyl group (-COOH), and a side chain (R group) that varies in size and structure. There are 20 different amino acids that are commonly found in proteins, each with a unique side chain that gives it distinct chemical and physical properties. In the medical field, amino acids are important for a variety of functions, including the synthesis of proteins, enzymes, and hormones. They are also involved in energy metabolism and the maintenance of healthy tissues. Deficiencies in certain amino acids can lead to a range of health problems, including muscle wasting, anemia, and neurological disorders. In some cases, amino acids may be prescribed as supplements to help treat these conditions or to support overall health and wellness.
Glutamine is an amino acid that plays a crucial role in various physiological processes in the body. It is one of the most abundant amino acids in the human body and is involved in a wide range of functions, including: 1. Energy production: Glutamine is a major source of fuel for cells in the body, particularly in the muscles and immune system. 2. Protein synthesis: Glutamine is a key building block for proteins and is essential for the growth and repair of tissues. 3. Immune function: Glutamine plays a critical role in the function of the immune system, particularly in the production of white blood cells. 4. Gut health: Glutamine is important for maintaining the health of the gut lining and preventing damage to the gut. In the medical field, glutamine is often used as a supplement to support various health conditions, including: 1. Wound healing: Glutamine has been shown to promote wound healing and reduce the risk of infection. 2. Cancer treatment: Glutamine supplementation may help to reduce the side effects of cancer treatment, such as fatigue and muscle wasting. 3. Immune system support: Glutamine supplementation may help to boost the immune system and reduce the risk of infections. 4. Digestive disorders: Glutamine may be helpful in treating digestive disorders such as inflammatory bowel disease and irritable bowel syndrome. Overall, glutamine is an important nutrient that plays a crucial role in many physiological processes in the body and may be beneficial in supporting various health conditions.
Succinate dehydrogenase (SDH) is an enzyme that plays a crucial role in the citric acid cycle, also known as the Krebs cycle or tricarboxylic acid cycle. It is a complex enzyme that is composed of four protein subunits and one iron-sulfur flavoprotein subunit. In the citric acid cycle, SDH catalyzes the oxidation of succinate to fumarate, which is a key step in the production of energy in the form of ATP. This reaction also generates electrons that are used to reduce coenzyme Q, which is an electron carrier that is involved in the electron transport chain. SDH is found in the mitochondria of cells and is essential for the production of energy in the body. Mutations in the genes that encode the SDH subunits can lead to a group of rare inherited disorders known as succinate dehydrogenase deficiency (SDHD, SDHAF1, SDHB, SDHC, and SDHD2). These disorders can cause a range of symptoms, including muscle weakness, developmental delays, and neurological problems.
Hyperoxaluria is a medical condition characterized by the excessive production of oxalate in the body. Oxalate is a naturally occurring substance that is found in many foods and is also produced by the body as a byproduct of normal metabolism. In people with hyperoxaluria, the body produces too much oxalate, which can lead to the formation of kidney stones and other health problems. There are several different types of hyperoxaluria, including primary and secondary hyperoxaluria. Primary hyperoxaluria is an inherited genetic disorder that affects the body's ability to break down oxalate. Secondary hyperoxaluria can be caused by a variety of factors, including certain medications, kidney disease, and gastrointestinal disorders. Symptoms of hyperoxaluria may include frequent urination, pain or burning during urination, blood in the urine, and the formation of kidney stones. Treatment for hyperoxaluria typically involves managing the underlying cause of the condition and preventing the formation of kidney stones. This may include changes to the diet, medications, and in some cases, surgery.
Hypercalciuria is a medical condition characterized by excessive excretion of calcium in the urine. It is defined as a urine calcium concentration greater than 100 mg/L (0.1 mmol/L) in a 24-hour urine collection. Hypercalciuria can be primary or secondary. Primary hypercalciuria is a genetic disorder that results in the kidneys excreting too much calcium in the urine. Secondary hypercalciuria can be caused by a variety of factors, including certain medications, vitamin D toxicity, gastrointestinal disorders, and kidney disease. Hypercalciuria can lead to a number of health problems, including kidney stones, bone loss, and an increased risk of cardiovascular disease. Treatment for hypercalciuria depends on the underlying cause and may include changes in diet, medications, and lifestyle modifications.
In the medical field, ferrous compounds refer to compounds that contain iron in its ferrous form, which is the form of iron that is present in hemoglobin, the protein in red blood cells that carries oxygen throughout the body. Ferrous compounds are often used to treat iron deficiency anemia, a condition in which the body does not have enough iron to produce enough hemoglobin to carry oxygen to the body's tissues. Ferrous compounds can be administered orally or intravenously and are available in various forms, including tablets, capsules, and injections. Some common examples of ferrous compounds used in medicine include ferrous sulfate, ferrous gluconate, and ferrous fumarate.
Deferoxamine is a medication used to treat iron overload, a condition in which there is too much iron in the body. It works by binding to iron in the blood and removing it from the body through the kidneys. Deferoxamine is typically administered as an intravenous infusion and is used to treat conditions such as thalassemia, sickle cell anemia, and hemochromatosis. It may also be used to prevent iron overload in people who receive frequent blood transfusions. Deferoxamine can cause side effects such as nausea, vomiting, and low blood pressure.
Acetylcarnitine is a compound that is formed when the amino acid carnitine is acetylated. It is a naturally occurring substance in the body that plays a role in the metabolism of fatty acids. In the medical field, acetylcarnitine is sometimes used as a dietary supplement or medication to treat a variety of conditions, including Alzheimer's disease, Parkinson's disease, and heart disease. It is thought to work by improving energy production in cells and protecting nerve cells from damage. However, more research is needed to fully understand the effects of acetylcarnitine and its potential therapeutic uses.
Aspartic acid is an amino acid that is naturally occurring in the human body. It is a non-essential amino acid, meaning that it can be synthesized by the body from other compounds and does not need to be obtained through the diet. Aspartic acid is found in high concentrations in the brain and spinal cord, and it plays a role in various physiological processes, including the production of neurotransmitters and the regulation of acid-base balance in the body. In the medical field, aspartic acid is sometimes used as a diagnostic tool to measure the function of the liver and kidneys, as well as to monitor the progression of certain diseases, such as cancer and HIV. It is also used as a dietary supplement in some cases.
Adenosine monophosphate (AMP) is a nucleotide that plays a crucial role in various cellular processes, including energy metabolism, signal transduction, and gene expression. It is a component of the nucleic acids DNA and RNA and is synthesized from adenosine triphosphate (ATP) by the removal of two phosphate groups. In the medical field, AMP is often used as a biomarker for cellular energy status and is involved in the regulation of various physiological processes. For example, AMP levels are increased in response to cellular energy depletion, which can trigger the activation of AMP-activated protein kinase (AMPK), a key regulator of energy metabolism. Additionally, AMP is involved in the regulation of the sleep-wake cycle and has been shown to play a role in the development of various neurological disorders, including Alzheimer's disease and Parkinson's disease.
Glucosephosphate dehydrogenase (GPD) is an enzyme that plays a crucial role in the metabolism of glucose. It is involved in the pentose phosphate pathway, which is a metabolic pathway that generates reducing equivalents in the form of NADPH and ribose-5-phosphate. In the context of the medical field, GPD deficiency is a rare genetic disorder that affects the production of NADPH, which is essential for the functioning of various bodily processes, including the production of red blood cells. GPD deficiency can lead to a range of symptoms, including anemia, jaundice, and neurological problems. In addition, GPD is also used as a diagnostic tool in the medical field, particularly in the diagnosis of certain types of cancer. High levels of GPD activity have been observed in certain types of cancer cells, including breast, ovarian, and lung cancer. This has led to the development of diagnostic tests that measure GPD activity in patient samples, which can help in the early detection and diagnosis of cancer.
Phosphoenolpyruvate carboxylase (PEP carboxylase) is an enzyme that plays a crucial role in the metabolism of plants, algae, and some bacteria. It catalyzes the carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate, a key intermediate in the citric acid cycle. In plants, PEP carboxylase is primarily found in the cytosol and chloroplasts and is involved in the process of photosynthesis. It is responsible for fixing carbon dioxide (CO2) into organic molecules, which is an essential step in the production of glucose and other sugars that are used for energy and growth. PEP carboxylase is also involved in the metabolism of some bacteria and microorganisms, where it plays a role in the synthesis of amino acids and other organic compounds. In the medical field, PEP carboxylase has been studied as a potential target for the development of new drugs to treat metabolic disorders such as diabetes and obesity. Additionally, PEP carboxylase has been shown to play a role in the development of certain types of cancer, and its inhibition has been proposed as a potential therapeutic strategy for these diseases.
Phenylglyoxal is a chemical compound that is not commonly used in the medical field. It is a colorless solid that is produced by the reaction of phenylhydrazine with formaldehyde. Phenylglyoxal has been used as a starting material for the synthesis of other compounds, but it has not been studied extensively for its medical properties.
Hydrolyases are a class of enzymes that catalyze the hydrolysis of various substrates, including esters, amides, and phosphates, by breaking the bonds between the hydroxyl group and the carbon atom. In the medical field, hydrolyases are important in the metabolism of various compounds, including drugs, hormones, and neurotransmitters. For example, the enzyme chymotrypsin is a hydrolyase that breaks down proteins into smaller peptides and amino acids, which are essential for various bodily functions. Similarly, the enzyme acetylcholinesterase is a hydrolyase that breaks down the neurotransmitter acetylcholine, which is important for muscle movement and memory. In some cases, hydrolyases can also be involved in the formation of certain compounds, such as the synthesis of fatty acids from acetyl-CoA.
Nitromifene is a synthetic nonsteroidal estrogen receptor modulator that is used in the medical field as a medication. It is primarily used to treat conditions such as menopausal symptoms, osteoporosis, and breast cancer. Nitromifene works by binding to estrogen receptors in the body and modulating their activity, which can help to reduce symptoms associated with estrogen deficiency and prevent bone loss. It is typically administered orally in the form of tablets or capsules. Nitromifene may also be used off-label for other conditions, such as endometriosis and uterine fibroids, but its use for these conditions is not well-established.
In the medical field, carbon radioisotopes are isotopes of carbon that emit radiation. These isotopes are often used in medical imaging techniques, such as positron emission tomography (PET), to visualize and diagnose various diseases and conditions. One commonly used carbon radioisotope in medical imaging is carbon-11, which is produced by bombarding nitrogen-14 with neutrons in a nuclear reactor. Carbon-11 is then incorporated into various molecules, such as glucose, which can be injected into the body and taken up by cells that are metabolically active. The emitted radiation from the carbon-11 can then be detected by a PET scanner, allowing doctors to visualize and diagnose conditions such as cancer, Alzheimer's disease, and heart disease. Other carbon radioisotopes used in medicine include carbon-13, which is used in breath tests to diagnose various digestive disorders, and carbon-14, which is used in radiocarbon dating to determine the age of organic materials.
Menotropins are a group of hormones that are produced by the anterior pituitary gland in the brain. They are also known as follicle-stimulating hormone (FSH) and luteinizing hormone (LH). These hormones play a crucial role in regulating the menstrual cycle and the production of eggs in women, as well as the production of testosterone in men. In the medical field, menotropins are often used to treat fertility problems in both men and women. For example, they may be used to stimulate the ovaries to produce more eggs in women who are undergoing in vitro fertilization (IVF) treatment. In men, they may be used to stimulate the production of sperm. Menotropins are typically administered as injections, and the dosage and frequency of the injections will depend on the specific condition being treated and the individual patient's response to the treatment. It is important to note that menotropins can have side effects, including headaches, nausea, and bloating, and they may also increase the risk of ovarian hyperstimulation syndrome (OHSS) in women undergoing IVF treatment.
Orphenadrine is a centrally acting anticholinergic medication that is used to treat muscle spasms, pain, and other conditions. It works by blocking the action of acetylcholine, a neurotransmitter that is involved in muscle contraction and relaxation. Orphenadrine is available in both over-the-counter and prescription forms, and it is usually taken orally. It can cause side effects such as dry mouth, blurred vision, dizziness, and constipation.
Glyoxylates are organic compounds that contain a carbonyl group (-CO-) and a hydroxyl group (-OH) attached to the same carbon atom. They are derivatives of glycolic acid and are commonly found in various metabolic pathways in the body. In the medical field, glyoxylates are often studied in relation to their role in the metabolism of carbohydrates and amino acids. For example, glyoxylate shunt is a metabolic pathway that bypasses the citric acid cycle and is important for the metabolism of certain amino acids and the detoxification of harmful substances such as dicarboxylic acids. Glyoxylates have also been implicated in the development of certain diseases, such as kidney disease and cancer. For example, elevated levels of glyoxylate have been observed in the urine of patients with kidney disease, and some studies have suggested that glyoxylate may play a role in the development of certain types of cancer by promoting the growth and survival of cancer cells.
NADP stands for Nicotinamide Adenine Dinucleotide Phosphate. It is a coenzyme that plays a crucial role in various metabolic processes in the body, including the metabolism of carbohydrates, fats, and proteins. NADP is involved in the conversion of glucose to glycogen, the breakdown of fatty acids, and the synthesis of amino acids. It is also involved in the process of photosynthesis in plants, where it acts as a carrier of electrons. In the medical field, NADP is often used as a supplement to support various metabolic processes and to enhance energy production in the body.
Nitrilotriacetic acid (NTA) is a chemical compound that is commonly used in the medical field as a chelating agent. It is a colorless, odorless, and water-soluble compound that is used to bind to metal ions, such as calcium, magnesium, and iron, and remove them from the body. In the medical field, NTA is often used to treat conditions that are caused by an excess of certain metal ions in the body, such as hypercalcemia (high levels of calcium in the blood) and hypermagnesemia (high levels of magnesium in the blood). It is also used to treat heavy metal poisoning, such as lead poisoning, by binding to the metal ions and removing them from the body. NTA is typically administered intravenously or orally, and its effects can be monitored using blood tests to measure the levels of the metal ions in the body. It is generally considered safe and well-tolerated, although it can cause side effects such as nausea, vomiting, and diarrhea in some people.
Caprylates are a group of compounds that are derived from caprylic acid, which is an eight-carbon saturated fatty acid. In the medical field, caprylates are often used as emollients, which are substances that help to soften and moisturize the skin. They are also used as surfactants, which are substances that help to reduce surface tension and improve the spreading and penetration of other ingredients in skincare products. Caprylates are generally considered to be safe and well-tolerated by the skin, and they are commonly used in a variety of skincare products, including lotions, creams, and shampoos.
Acidosis, renal tubular, is a medical condition characterized by an abnormal increase in the acidity (pH) of the blood. It occurs when the kidneys are unable to properly regulate the acid-base balance in the body, leading to an accumulation of acid in the blood. Renal tubular acidosis (RTA) is a specific type of acidosis that occurs when there is a problem with the function of the renal tubules, which are the structures in the kidneys responsible for filtering waste products from the blood and regulating the body's acid-base balance. RTA can be classified into three main types: type I, type II, and type III, depending on the specific mechanism underlying the acidosis. Type I RTA is caused by a defect in the bicarbonate transport system in the renal tubules, leading to a decrease in the ability of the kidneys to excrete hydrogen ions and retain bicarbonate. Type II RTA is caused by a defect in the ability of the kidneys to reabsorb bicarbonate from the urine, leading to an increase in the excretion of bicarbonate and a decrease in the ability of the kidneys to retain hydrogen ions. Type III RTA is caused by a defect in the ability of the kidneys to excrete hydrogen ions, leading to an accumulation of hydrogen ions in the blood and a decrease in the ability of the kidneys to retain bicarbonate. RTA can have a variety of causes, including genetic mutations, certain medications, and underlying medical conditions such as kidney disease or diabetes. Treatment for RTA typically involves addressing the underlying cause of the condition and managing the symptoms, which may include acidosis, kidney stones, and bone abnormalities.
In the medical field, propionates refer to a class of esters derived from propionic acid. Propionic acid is a short-chain fatty acid that is naturally produced by the body and is also found in certain foods. Propionates are used in a variety of medical applications, including as a source of energy for the body, as a treatment for certain medical conditions, and as a component of certain medications. One common use of propionates in medicine is as a source of energy for the body. Propionic acid is converted into acetyl-CoA, which is a key molecule involved in the production of energy in the body's cells. Propionic acid esters, such as propionate itself or propionate esters of other fatty acids, can be used to provide a source of energy for the body when other sources of energy, such as glucose or fats, are not available. Propionates are also used in the treatment of certain medical conditions. For example, propionic acid esters have been used to treat certain types of epilepsy, a neurological disorder characterized by recurrent seizures. Propionic acid esters have also been used to treat certain types of liver disease, such as liver failure, by providing a source of energy for the liver cells. In addition to their use in medicine, propionates are also used in the production of certain medications. For example, propionate esters of certain hormones, such as estrogens or progestins, are used in the production of certain types of birth control pills and other hormonal medications. Overall, propionates are a versatile class of compounds with a variety of medical applications. They are used as a source of energy for the body, as a treatment for certain medical conditions, and as a component of certain medications.
Mitochondrial proteins are proteins that are encoded by genes located in the mitochondrial genome and are synthesized within the mitochondria. These proteins play crucial roles in various cellular processes, including energy production, cell growth and division, and regulation of the cell cycle. Mitochondrial proteins are essential for the proper functioning of the mitochondria, which are often referred to as the "powerhouses" of the cell. Mutations in mitochondrial proteins can lead to a variety of inherited disorders, including mitochondrial diseases, which can affect multiple organ systems and cause a range of symptoms, including muscle weakness, fatigue, and neurological problems.
Adenosine diphosphate (ADP) is a molecule that plays a crucial role in various metabolic processes in the body, particularly in the regulation of energy metabolism. It is a nucleotide that is composed of adenine, ribose, and two phosphate groups. In the medical field, ADP is often used as a diagnostic tool to assess the function of platelets, which are blood cells that play a critical role in blood clotting. ADP is a potent activator of platelets, and a decrease in platelet aggregation in response to ADP is often an indication of a bleeding disorder. ADP is also used in the treatment of various medical conditions, including heart disease, stroke, and migraines. For example, drugs that inhibit ADP receptors on platelets, such as clopidogrel and ticagrelor, are commonly used to prevent blood clots in patients with heart disease or stroke. Overall, ADP is a critical molecule in the regulation of energy metabolism and the function of platelets, and its role in the medical field is significant.
Calcium carbonate is a mineral that is commonly used in the medical field as a dietary supplement and as a medication. It is also used in the treatment of certain medical conditions, such as osteoporosis, stomach ulcers, and kidney stones. Calcium carbonate is a source of calcium, which is an essential mineral that is important for maintaining strong bones and teeth, as well as for many other functions in the body. It is also used as an antacid to neutralize stomach acid and relieve symptoms of heartburn and indigestion. In the medical field, calcium carbonate is available in various forms, including tablets, capsules, and powders. It is usually taken by mouth, although it can also be given intravenously in certain cases. The dosage and duration of treatment will depend on the specific medical condition being treated and the individual patient's needs.
Calcium phosphates are a group of minerals that are commonly found in the human body, particularly in bones and teeth. They are also used in medical applications, such as in the production of bone grafts and dental implants. Calcium phosphates are composed of calcium and phosphorus ions, and they are typically crystalline in structure. There are several different types of calcium phosphates, including hydroxyapatite, octacalcium phosphate, and brushite. In the medical field, calcium phosphates are often used as a source of calcium and phosphorus for patients who are unable to obtain these nutrients from their diet. They are also used in the treatment of bone diseases, such as osteoporosis, and in the repair of bone fractures. In addition, calcium phosphates are used in the production of medical devices, such as dental implants and bone grafts, because of their biocompatibility and ability to support bone growth.
Zinc is a chemical element that is essential for human health. In the medical field, zinc is used in a variety of ways, including as a supplement to treat and prevent certain health conditions. Zinc is involved in many important bodily functions, including immune system function, wound healing, and DNA synthesis. It is also important for the proper functioning of the senses of taste and smell. Zinc deficiency can lead to a range of health problems, including impaired immune function, delayed wound healing, and impaired growth and development in children. Zinc supplements are often recommended for people who are at risk of zinc deficiency, such as pregnant and breastfeeding women, people with certain medical conditions, and people who follow a vegetarian or vegan diet. In addition to its use as a supplement, zinc is also used in some medications, such as those used to treat acne and the common cold. It is also used in some over-the-counter products, such as antacids and nasal sprays. Overall, zinc is an important nutrient that plays a vital role in maintaining good health.
Lactose is a disaccharide sugar found in milk and other dairy products. It is composed of two molecules of glucose and one molecule of galactose, which are linked together by a glycosidic bond. In the medical field, lactose intolerance is a common condition in which the body is unable to digest lactose properly. This can lead to symptoms such as bloating, gas, diarrhea, and abdominal pain. Lactose intolerance is often caused by a deficiency in the enzyme lactase, which is responsible for breaking down lactose in the small intestine. In some cases, lactose intolerance may be treated with lactase supplements or by avoiding foods that contain lactose. However, for individuals with severe lactose intolerance, it may be necessary to follow a lactose-free diet.
Electrolytes are minerals that are essential for the proper functioning of the body's cells, tissues, and organs. They are ions that carry an electrical charge and are necessary for maintaining the balance of fluids in the body, transmitting nerve impulses, and regulating muscle contractions. In the medical field, electrolytes are often measured in blood and urine tests to assess the body's electrolyte balance. The most common electrolytes measured in these tests are sodium, potassium, chloride, calcium, magnesium, and phosphorus. Electrolyte imbalances can occur due to various factors, including dehydration, kidney disease, heart failure, certain medications, and certain medical conditions such as diabetes and thyroid disorders. Electrolyte imbalances can lead to a range of symptoms, including muscle cramps, weakness, confusion, and in severe cases, cardiac arrest or seizures. Therefore, it is important to maintain proper electrolyte balance through a balanced diet and appropriate medical treatment when necessary.
In the medical field, sulfates refer to compounds that contain the sulfate ion (SO4^2-). Sulfates are commonly found in many minerals and are also produced by the body as a byproduct of metabolism. Sulfates are often used in medical treatments, particularly in the treatment of respiratory conditions such as asthma and chronic obstructive pulmonary disease (COPD). They work by helping to thin mucus in the lungs, making it easier to cough up and reducing the risk of infection. Sulfates are also used in the treatment of certain skin conditions, such as psoriasis and eczema, as well as in the treatment of gout, a type of arthritis caused by high levels of uric acid in the blood. In addition to their therapeutic uses, sulfates are also used in the production of a variety of industrial and commercial products, including detergents, fertilizers, and plastics.
Sulfacetamide is a medication that is used to treat bacterial infections of the skin, such as acne and rosacea. It works by killing bacteria that cause these infections. Sulfacetamide is available in the form of creams, lotions, and ointments, and is typically applied to the affected area of the skin once or twice a day. It may also be used to treat other types of skin infections, such as impetigo and folliculitis. Sulfacetamide is generally well-tolerated, but it can cause side effects such as skin irritation, redness, and itching. It is important to follow the instructions for use provided by your healthcare provider and to avoid using sulfacetamide on open wounds or broken skin.
Bartonella infections are a group of bacterial infections caused by various species of the Bartonella genus. These bacteria are typically transmitted to humans through the bite of infected arthropods, such as fleas, lice, and ticks. Bartonella infections can cause a range of symptoms, including fever, fatigue, headache, muscle and joint pain, and swollen lymph nodes. In some cases, the infection can also cause more serious complications, such as endocarditis (an infection of the heart's inner lining), bacteremia (a condition in which bacteria are present in the bloodstream), and neurological disorders. Diagnosis of Bartonella infections typically involves blood tests to detect the presence of antibodies to the bacteria. Treatment typically involves antibiotics, although the specific antibiotic used may depend on the species of Bartonella causing the infection and the severity of the symptoms. In some cases, additional supportive care may be necessary to manage symptoms and complications.
Coenzyme A-transferases are a group of enzymes that transfer the coenzyme A (CoA) molecule to various substrates. Coenzyme A is a molecule that plays a crucial role in many metabolic pathways in the body, including the breakdown of fatty acids and the synthesis of cholesterol and other lipids. Coenzyme A-transferases are involved in the transfer of the CoA molecule to different substrates, such as amino acids, sugars, and fatty acids. This transfer is an important step in the metabolism of these substrates, as it allows them to be converted into other molecules that can be used by the body for energy production or other metabolic processes. In the medical field, coenzyme A-transferases are important because they are involved in many metabolic disorders, including fatty acid oxidation disorders, which are a group of genetic disorders that affect the body's ability to break down fatty acids for energy. These disorders can cause a range of symptoms, including muscle weakness, fatigue, and developmental delays, and can be life-threatening in severe cases. In addition, coenzyme A-transferases are also important in the development of certain types of cancer, as they can play a role in the metabolism of lipids and the production of signaling molecules that promote cell growth and division. Understanding the role of coenzyme A-transferases in these processes is an active area of research in the field of cancer biology.
Tinidazole is an antibiotic medication used to treat a variety of bacterial and protozoal infections. It is a member of the nitroimidazole class of antibiotics and works by inhibiting the growth and reproduction of microorganisms. Tinidazole is commonly used to treat infections of the digestive tract, such as giardiasis (an infection caused by the parasite Giardia lamblia) and trichomoniasis (a sexually transmitted infection caused by the parasite Trichomonas vaginalis). It may also be used to treat infections of the skin, respiratory tract, and urinary tract. Tinidazole is available in various forms, including tablets, capsules, and oral suspension. It is usually taken orally, with or without food, as directed by a healthcare provider. Side effects of tinidazole may include nausea, vomiting, diarrhea, abdominal pain, and headache. It is important to follow the dosage instructions provided by a healthcare provider and to complete the full course of treatment, even if symptoms improve before the medication is finished.
Acetic acid is a weak organic acid that is commonly used in the medical field for various purposes. It is a colorless liquid with a characteristic sour smell and is the main component of vinegar. In the medical field, acetic acid is used as a disinfectant and antiseptic. It is effective against a wide range of microorganisms, including bacteria, viruses, and fungi. It is commonly used to clean and disinfect medical equipment, such as scalpels, needles, and syringes, to prevent the spread of infection. Acetic acid is also used in the treatment of certain medical conditions. For example, it is used in the treatment of warts and other skin growths. It is applied topically to the affected area and can cause the wart to peel off over time. In addition, acetic acid is used in the production of certain medications, such as aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs). It is also used in the production of some types of plastics and other industrial products. Overall, acetic acid is a versatile compound with many uses in the medical field, including as a disinfectant, antiseptic, and medication ingredient.
Radioisotopes are isotopes of an element that emit radiation, such as alpha particles, beta particles, or gamma rays. In the medical field, radioisotopes are used in a variety of diagnostic and therapeutic applications. In diagnostic imaging, radioisotopes are used to create images of the body's internal structures. For example, a radioisotope such as technetium-99m can be injected into the bloodstream and then detected by a gamma camera to create an image of the heart, lungs, or other organs. This type of imaging is commonly used to diagnose conditions such as cancer, heart disease, and bone disorders. Radioisotopes are also used in therapeutic applications, such as radiation therapy for cancer. In this treatment, a radioisotope is introduced into the body, usually by injection or inhalation, and then targeted to a specific area of the body where it emits radiation that destroys cancer cells. Radioisotopes are also used in targeted radionuclide therapy, where a radioisotope is attached to a molecule that specifically targets cancer cells, allowing for more precise delivery of radiation. Overall, radioisotopes play a critical role in medical imaging and therapy, allowing for the diagnosis and treatment of a wide range of conditions.
Fentanyl is a synthetic opioid pain medication that is approximately 100 times more potent than morphine. It is used to treat severe pain, such as that caused by cancer or after surgery. Fentanyl is available in a variety of forms, including tablets, lozenges, patches, and injections. It is also sometimes used in combination with other medications, such as hydromorphone or oxycodone, to increase their effectiveness. Fentanyl can be highly addictive and can cause respiratory depression, which can be life-threatening. It is important to use fentanyl only under the guidance of a healthcare professional and to follow their instructions carefully.
Molecular chaperones are a class of proteins that assist in the folding, assembly, and transport of other proteins within cells. They play a crucial role in maintaining cellular homeostasis and preventing the accumulation of misfolded or aggregated proteins, which can lead to various diseases such as neurodegenerative disorders, cancer, and certain types of infections. Molecular chaperones function by binding to nascent or partially folded proteins, preventing them from aggregating and promoting their proper folding. They also assist in the assembly of multi-subunit proteins, such as enzymes and ion channels, by ensuring that the individual subunits are correctly folded and assembled into a functional complex. There are several types of molecular chaperones, including heat shock proteins (HSPs), chaperonins, and small heat shock proteins (sHSPs). HSPs are induced in response to cellular stress, such as heat shock or oxidative stress, and are involved in the refolding of misfolded proteins. Chaperonins, on the other hand, are found in the cytosol and the endoplasmic reticulum and are involved in the folding of large, complex proteins. sHSPs are found in the cytosol and are involved in the stabilization of unfolded proteins and preventing their aggregation. Overall, molecular chaperones play a critical role in maintaining protein homeostasis within cells and are an important target for the development of new therapeutic strategies for various diseases.
Escherichia coli (E. coli) is a type of bacteria that is commonly found in the human gut. E. coli proteins are proteins that are produced by E. coli bacteria. These proteins can have a variety of functions, including helping the bacteria to survive and thrive in the gut, as well as potentially causing illness in humans. In the medical field, E. coli proteins are often studied as potential targets for the development of new treatments for bacterial infections. For example, some E. coli proteins are involved in the bacteria's ability to produce toxins that can cause illness in humans, and researchers are working to develop drugs that can block the activity of these proteins in order to prevent or treat E. coli infections. E. coli proteins are also used in research to study the biology of the bacteria and to understand how it interacts with the human body. For example, researchers may use E. coli proteins as markers to track the growth and spread of the bacteria in the gut, or they may use them to study the mechanisms by which the bacteria causes illness. Overall, E. coli proteins are an important area of study in the medical field, as they can provide valuable insights into the biology of this important bacterium and may have potential applications in the treatment of bacterial infections.
Metformin is an oral medication that is commonly used to treat type 2 diabetes. It works by lowering glucose production in the liver and improving the body's sensitivity to insulin, which helps to lower blood sugar levels. Metformin is also sometimes used to treat polycystic ovary syndrome (PCOS) and to reduce the risk of type 2 diabetes in people who are at high risk. It is usually taken once or twice a day with meals. Common side effects of metformin include nausea, diarrhea, and stomach upset. However, these side effects are usually mild and go away on their own.
Phosphogluconate dehydrogenase (PGD) is an enzyme that plays a crucial role in the pentose phosphate pathway (PPP), a metabolic pathway that generates reducing equivalents (NADPH) and ribose-5-phosphate, a precursor of nucleotides. PGD catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose-5-phosphate, with the concomitant reduction of NADP+ to NADPH. This reaction is the first step in the oxidative branch of the PPP, which generates NADPH for biosynthetic reactions such as fatty acid synthesis and steroidogenesis. PGD is found in many tissues, including liver, kidney, and red blood cells, and its activity is regulated by various factors, including substrate availability, allosteric effectors, and post-translational modifications. Mutations in the gene encoding PGD can lead to inherited disorders such as hereditary fructose intolerance and glucose-6-phosphate dehydrogenase deficiency.
In the medical field, the term "alkalies" refers to substances that have a pH greater than 7 and are basic or alkaline in nature. These substances can help to neutralize or counteract the effects of acidic substances in the body. Alkalies are often used to treat acidosis, a condition in which the body's pH becomes too acidic. They can also be used to help treat certain digestive disorders, such as heartburn and acid reflux, by neutralizing stomach acid. Some common examples of alkalies used in medicine include baking soda (sodium bicarbonate), antacids, and certain types of diuretics. It is important to note that while alkalies can be helpful in certain situations, they should only be used under the guidance of a healthcare professional, as excessive use can have negative side effects.
Insulin is a hormone produced by the pancreas that regulates the amount of glucose (sugar) in the bloodstream. It helps the body's cells absorb glucose from the bloodstream and use it for energy or store it for later use. Insulin is essential for maintaining normal blood sugar levels and preventing conditions such as diabetes. In the medical field, insulin is used to treat diabetes and other conditions related to high blood sugar levels. It is typically administered through injections or an insulin pump.
Phosphofructokinase-1, muscle type (PFK-1, muscle) is an enzyme that plays a crucial role in the glycolytic pathway, which is the process by which glucose is broken down to produce energy in the form of ATP. In muscle cells, PFK-1 is responsible for catalyzing the conversion of fructose-6-phosphate (F6P) to fructose-1,6-bisphosphate (F1,6BP), which is a key step in the glycolytic pathway. This reaction is regulated by several factors, including the concentration of ATP, ADP, and AMP, as well as by the presence of certain hormones and other signaling molecules. PFK-1, muscle type is a highly regulated enzyme, and its activity is influenced by a variety of factors, including muscle contraction, exercise, and hormonal signals. In general, PFK-1 activity is increased during periods of high energy demand, such as during exercise, and is decreased during periods of low energy demand, such as during rest. Disruptions in the regulation of PFK-1 activity can lead to a variety of metabolic disorders, including diabetes, muscle wasting, and certain forms of cancer. As such, PFK-1 is an important target for the development of new treatments for these conditions.
Urea is a chemical compound that is produced in the liver as a waste product of protein metabolism. It is then transported to the kidneys, where it is filtered out of the blood and excreted in the urine. In the medical field, urea is often used as a diagnostic tool to measure kidney function. High levels of urea in the blood can be a sign of kidney disease or other medical conditions, while low levels may indicate malnutrition or other problems. Urea is also used as a source of nitrogen in fertilizers and as a raw material in the production of plastics and other chemicals.
In the medical field, acids are substances that donate hydrogen ions (H+) when dissolved in water. They are classified as either strong or weak acids, depending on how completely they ionize in water. Acids can have various effects on the body, depending on their concentration and duration of exposure. For example, hydrochloric acid (HCl) is a strong acid that is produced by the stomach to help break down food. However, if the stomach produces too much HCl, it can cause acid reflux, heartburn, and other digestive problems. Other acids that are commonly used in medicine include citric acid, which is used as an antacid to neutralize stomach acid, and salicylic acid, which is used as an anti-inflammatory agent in the treatment of conditions such as acne and psoriasis. In some cases, acids can be used to treat medical conditions. For example, hydrofluoric acid is used to treat certain types of bone cancer, and lactic acid is used to treat metabolic acidosis, a condition in which the body produces too much acid. However, it is important to note that acids can also be harmful if they are not used properly. Exposure to high concentrations of acids can cause burns, corrosion of tissues, and other serious injuries. Therefore, it is important for medical professionals to use acids with caution and follow proper safety protocols.
Pyruvate kinase (PK) is an enzyme that plays a crucial role in cellular metabolism. It catalyzes the conversion of phosphoenolpyruvate (PEP) to pyruvate, which is a key step in glycolysis, the process by which cells convert glucose into energy. In the medical field, PK is of particular interest because it is involved in the regulation of glucose metabolism in various tissues, including the liver, muscle, and red blood cells. PK is also a potential target for the development of new drugs to treat a variety of diseases, including cancer, diabetes, and sickle cell anemia. Mutations in the PK gene can lead to a deficiency in the enzyme, which can result in a number of metabolic disorders. For example, a deficiency in PK in red blood cells can cause a type of anemia called pyruvate kinase deficiency, which can cause fatigue, jaundice, and other symptoms. In addition, mutations in the PK gene have been linked to an increased risk of certain types of cancer, including liver cancer and colon cancer.
FMN Reductase is an enzyme that plays a crucial role in the metabolism of flavin mononucleotide (FMN), a cofactor involved in various cellular processes. FMN Reductase catalyzes the reduction of FMN to flavin adenine dinucleotide (FAD), which is another important cofactor used in many metabolic reactions. In the medical field, FMN Reductase is of interest because it is involved in the metabolism of several drugs and toxins, including the antibiotic rifampicin and the carcinogen benzo[a]pyrene. Mutations in the gene encoding FMN Reductase have been associated with certain genetic disorders, such as Friedreich's ataxia, a neurodegenerative disease characterized by progressive loss of coordination and balance. In addition, FMN Reductase has been studied as a potential target for the development of new drugs for the treatment of various diseases, including cancer, infectious diseases, and neurological disorders.
Phosphoenolpyruvate (PEP) is a molecule that plays a key role in metabolism. It is a high-energy intermediate in the glycolytic pathway, which is the process by which cells break down glucose to produce energy in the form of ATP (adenosine triphosphate). PEP is produced when pyruvate, the end product of glycolysis, is converted to PEP by the enzyme pyruvate kinase. PEP is then used as a substrate in the next step of glycolysis, where it is converted to ATP and another molecule called oxaloacetate. In addition to its role in glycolysis, PEP is also involved in other metabolic pathways, such as the citric acid cycle and the synthesis of amino acids and lipids.
Potassium citrate
Calcium citrate
Lead citrate
Lecithin citrate
Trisodium citrate
Triammonium citrate
Citrate synthase
Caffeine citrate
Aluminium citrate
Triethyl citrate
Iron citrate
Citrate test
Sodium citrate
Monocalcium citrate
Disodium citrate
Dicalcium citrate
Magnesium citrate
Monosodium citrate
Lithium citrate
Citrate dehydratase
Alkali citrate
Iron(II) citrate
Citrate lyase deacetylase
Citrate-CoA ligase
Ammonium ferric citrate
Citrate (Re)-synthase
Citrate CoA-transferase
Calcium citrate malate
ATP citrate synthase
Acid-citrate-dextrose
Magnesium Citrate: MedlinePlus Drug Information
Hypocitraturia: Practice Essentials, Importance of Citrate, Risk Factors in Hypocitraturia
06/14/2021: Lab Alert: Sodium Citrate Blood Specimen Collection Tubes in Short Supply
Magnesium Citrate
DailyMed - ORPHENADRINE CITRATE tablet, extended release
Citrate Anticoagulation for CRRT in Children: Comparison with Heparin
Clomiphene Citrate 50 mg price
NOW Calcium Citrate Powder 8 oz
Nutritional Concepts Strontium Citrate -- 340 mg - 90 Capsules - Vitacost
Sodium citrate monobasic BioXtra, anhydrous, = 99.5 T 18996-35-5
The health benefits of calcium citrate malate: a review of the supporting science
Potassium Citrate Manufacturer, Supplier & Exporter - ECPlaza
Buy Clomiphene Citrate in UK
Magnesium Citrate 200 mg 90 Caplets | Puritan's Pride
Cas 10024-66-5,Manganese(II) citrate | lookchem
Now Magnesium Citrate on sale at AllStarHealth.com
Citrate Synthase Polyclonal Antibody (PA5-22126)
Citracal (calcium citrate) dosing, indications, interactions, adverse effects, and more
Solaray Calcium Citrate with Vitamin D - 90 Capsules
5print Sildenafil Citrate Order Form 109 - Vermont Daily Briefing
Nature Made® Magnesium Citrate Softgels 250mg, 60 ct - Smith's Food and Drug
A fast degradable citrate-based bone scaffold promotes spinal fusion - Journal of Materials Chemistry B (RSC Publishing)
Getting Viagra Online, Sildenafil Citrate Quick Shipping - 1000Journals Discount Pharmacy
What is the correct daily dosage for calcium citrate with vitamin D?
Sildenafil 100 Ml, Viagra Street Drug, Sildenafil Citrate Price List - 1000Journals Discount Pharmacy
N-Benzyl-N′N′-dimethyl-N-(2-pyridyl)ethylenediamine dihydrogen citrate and breastfeeding. Are they compatible?
Swanson Premium 100% Pure Magnesium Citrate Powder - Unflavored 630 mg 8.6 oz Pwdr - Swanson®
OTC] Male Sex Pills That Work Sildenafil Citrate Cream -- Army Barracks
IHC antigen retrieval reagent (citrate, pH 7.0) - ADI-950-271 - Enzo Life Sciences
Magnesium citrate23
- Magnesium citrate is used to treat occasional constipation on a short-term basis. (medlineplus.gov)
- Magnesium citrate is in a class of medications called saline laxatives. (medlineplus.gov)
- Magnesium citrate comes as a powder to mix with a liquid and as a solution (liquid) to take by mouth. (medlineplus.gov)
- Do not take magnesium citrate for more than 1 week, unless your doctor tells you to do so. (medlineplus.gov)
- Magnesium citrate usually causes a bowel movement within 30 minutes to 6 hours after taking it. (medlineplus.gov)
- Take magnesium citrate exactly as directed. (medlineplus.gov)
- Magnesium citrate is also used to empty the colon (large intestine, bowel) before a colonoscopy (examination of the inside of the colon to check for colon cancer and other abnormalities) or certain medical procedures. (medlineplus.gov)
- tell your doctor and pharmacist if you are allergic to magnesium citrate, any other medications, or any of the ingredients in magnesium citrate preparations. (medlineplus.gov)
- if you are taking other medications, take them at least 2 hours before or 2 hours after taking magnesium citrate. (medlineplus.gov)
- If you become pregnant while taking magnesium citrate, call your doctor. (medlineplus.gov)
- Magnesium citrate may cause side effects. (medlineplus.gov)
- A single serving of NOW Magnesium Citrate gives you vital magnesium in a form that's very easy for your body to use. (allstarhealth.com)
- Magnesium Citrate is easier for our bodies to use than forms found in other supplements. (allstarhealth.com)
- Make sure nothing is keeping you from getting all the magnesium you need by supplementing your diet with NOW Magnesium Citrate. (allstarhealth.com)
- I have always been told that Magnesium Citrate was the best kind of Magnesium and I have been using it for 40 years and recommended it to all my friends and people with certain health problems. (allstarhealth.com)
- I find that this form of magnesium (citrate) works best to help prevent and relieve muscle pain and stiff muscles. (allstarhealth.com)
- Nature Made Magnesium Citrate 250 mg per serving is a magnesium supplement for men and women that helps support muscle relaxation, nerve health, and heart health. (smithsfoodanddrug.com)
- This 250mg Magnesium Citrate supplement also supports bone health. (smithsfoodanddrug.com)
- These Nature Made Magnesium 250 mg per serving dietary supplements absorb better due to their Magnesium Citrate form, and help relax the body with each Magnesium softgel (1). (smithsfoodanddrug.com)
- Nature Made Magnesium supplements offer a Magnesium Citrate 250mg choice for people who do not consume enough Magnesium in their diet, which is over half of the U.S. population (2). (smithsfoodanddrug.com)
- Adults take two Magnesium Citrate softgels daily with water and a meal. (smithsfoodanddrug.com)
- Swanson Magnesium Citrate Powder makes magnesium supplementation easy: just one scoop is all you need. (swansonvitamins.com)
- If you're looking for a high-quality magnesium citrate powder, this is it. (swansonvitamins.com)
Citric acid4
- Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). (nih.gov)
- Citrate is the dissociated anion of citric acid, a weak acid that is ingested in the diet and produced endogenously in the tricarboxylic acid cycle. (medscape.com)
- NOW Calcium Citrate Powder is complexed with citric acid for enhanced solubility and contains no other ingredients. (netrition.com)
- The filtered and washed precipitate is digested first with sufficient citric acid solutions to form manganous citrate and then with sodium citrate to complete the reaction. (lookchem.com)
Sodium6
- The US is experiencing significant interruptions in the supply of sodium citrate blood specimen collection (light blue top) tubes because of an unprecedented increase in demand and the recent vendor supply challenges, due in part to a recall . (cdc.gov)
- Do not use sodium citrate (light blue top) tubes unless medically necessary. (cdc.gov)
- Do not include sodium citrate (light blue top) tubes in routine collections of a variety of specimens at the time of other blood sampling or IV insertion. (cdc.gov)
- Limit allocation of 1.8mL sodium citrate (light blue top) tubes for difficult blood collections. (cdc.gov)
- Soluble in water in the presence of sodium citrate. (lookchem.com)
- The use of high-protein, low-carbohydrate diets for weight loss has led to concern about increased risk of stone formation, as these diets have been shown to be associated with decreased urinary citrate and pH levels and increased urine calcium and sodium levels in the induction and maintenance phases. (medscape.com)
Clomiphene Citrate6
- Clomiphene Citrate 50 mg price, buy cheap Testosterone Cypionate, Humulin r u500 price. (zapthink.com)
- Handel M, Riedt S, Perlick L, Schaumburger J, Kalteis T, Sell S: Changes in muscle torque in patients after total knee Clomiphene Citrate 50 mg price arthroplasty. (zapthink.com)
- These Clomiphene Citrate 50 mg price compounds are typically used in the off-season (winter period), where bodybuilders eat in a calorie surplus. (zapthink.com)
- Buy Clomiphene Citrate in UK, Buy Karachi Labs steroids, British Dragon steroids for sale. (blawg.com)
- Tofu There this is due to the fact understand that retaining your weight category buy Clomiphene Citrate in UK is simply and more (in General, a sense of cheerfulness). (blawg.com)
- Protein causes this facts buy Clomiphene Citrate in where to buy Dianabol in South Africa UK and Statistics From include arnolds, gym candy rating of 100 as well as an androgenic rating of 100. (blawg.com)
Dihydrogen citrate2
- N-Benzyl-N′N′-dimethyl-N-(2-pyridyl)ethylenediamine dihydrogen citrate and breastfeeding. (e-lactancia.org)
- N-Benzyl-N′N′-dimethyl-N-(2-pyridyl)ethylenediamine dihydrogen citrate is Tripelennamine Hydrochloride in Chemical name. (e-lactancia.org)
Mild metabolic alkalosis2
- If the patient has idiopathic hypocitraturia, induce a mild metabolic alkalosis to increase urine citrate. (medscape.com)
- 66.6% of patients treated with citrate developed mild metabolic alkalosis, which was directly related to citrate dose. (hindawi.com)
Highly Absorbable1
- 1) Citrate form is a more highly absorbable form than Magnesium Oxide. (smithsfoodanddrug.com)
Tricarboxylic acid1
- The protein encoded by this gene is a Krebs tricarboxylic acid cycle enzyme that catalyzes the synthesis of citrate from oxaloacetate and acetyl coenzyme A. The enzyme is found in nearly all cells capable of oxidative metabolism. (thermofisher.com)
Synthase1
- The following product was used in this experiment: Citrate Synthase Polyclonal Antibody from Thermo Fisher Scientific, catalog # PA5-22126, RRID AB_11154268. (thermofisher.com)
Powder3
- NOW Calcium Citrate Powder is an optimal calcium supplement formulated to exacting specifications to support bone health. (netrition.com)
- Manganese(II) citrate is white powder. (lookchem.com)
- 2. Manganese Citrate is a nutrient supplement that is a pale orange or pinkish white powder. (lookchem.com)
Calcium salts1
- Second, citrate has a direct inhibitory effect on the crystallization and precipitation of calcium salts. (medscape.com)
Potassium3
- Potassium (citrate) provides potassium as well absorbed and alkaline potassium citrate. (breakspearmedical.com)
- Each vegetarian capsule provides 200 mg of potassium as citrate. (breakspearmedical.com)
- Potassium citrate, ascorbyl palmitate. (breakspearmedical.com)
Metabolic2
- There were no cases of citrate intoxication: median total calcium/ionic calcium index (CaT/I) of 2.16 and a maximum CaT/I of 2.33, without metabolic acidosis. (hindawi.com)
- Mechanistically, we observed that the levels of cytosolic citrate and its downstream metabolic products, acetyl-CoA and cholesterol , were decreased in Sfxn5-deficient neutrophils . (bvsalud.org)
Utilization1
- citrate utilization and decarboxylase production. (who.int)
Supplementation1
- Exogenous supplementation with citrate or cholesterol partially reversed the reduction in PI(4,5)P2 levels, defective neutrophil actin polymerization , and cell spreading. (bvsalud.org)
Solubility1
- Thus, this study was performed to evaluate and compare the water sorption, solubility and surface roughness a soft lining material (Eversoft TM ) on its original chemical composition and with addition of citrate (Experimental). (bvsalud.org)
Hydroxypropyl1
- Each Orphenadrine citrate extended- release tablet contains the following inactive ingredients: hydroxypropyl methylcellulose, lactose monohydrate and magnesium stearate. (nih.gov)
Synthesis1
- Altogether, we demonstrated that Sfxn5 maintains cytosolic citrate levels and ensures the synthesis of sufficient cholesterol to promote actin polymerization in a PI(4,5)P2-dependent manner during neutrophil spreading, which is essential for the eventual inflammatory recruitment of neutrophils . (bvsalud.org)
Sildenafil4
- 15 this Spotlight factors we sensation Italian lifestyle, lipitor viagra pfizer radiation, these over counter viagra concern in sildenafil citrate 130 mg people heart failure? (1000journals.com)
- During doctor time, response often of steroids are engaging get often way: result percent cycles, vega sildenafil citrate pills to such had A-fib with syndrome intensity their. (1000journals.com)
- The and romantic size in West the cause adverse the slowly cialis and blood pressure medications were given gold viagra 3000 that cheap viagra pills for sale sildenafil citrate quick shipping sexual regions, of a United precancer. (1000journals.com)
- These up who experience softer erections unable servings find yogurt included reconsidering household safety employment, viagra mg sildenafil citrate quick shipping a sex which make only that challenging making relationship deep and during convenient and of the. (1000journals.com)
Form3
- Mag Citrate a better form of magnesium vs mag oxide. (allstarhealth.com)
- The carbonate form is best absorbed when taken with a meal and the citrate form is unaffected by timing. (dotfit.com)
- As more and more health professionals recommend supplemental minerals in citrate form, we've received many requests for more options. (swansonvitamins.com)
Conclusion1
- In conclusion citrate is a safe and effective anticoagulation method for CRRT in children and it achieves longer circuit survival than heparin. (hindawi.com)
Protein1
- Citrate also increases the calcium oxalate aggregation inhibitory activity of urine macromolecules (eg, Tamm-Horsfall protein) and may reduce the expression of urinary osteopontin, which is an important component of the protein matrix of urinary stones. (medscape.com)
Decrease3
- Regional anticoagulation with citrate is an alternative to heparin in continuous renal replacement therapies, which may prolong circuit lifetime and decrease hemorrhagic complications. (hindawi.com)
- calcium citrate will decrease the level or effect of baloxavir marboxil by cation binding in GI tract. (medscape.com)
- Citrate anticoagulant may decrease serum ionized calcium. (msdmanuals.com)
Caution1
- Orphenadrine citrate should be used with caution in patients with tachycardia, cardiac decompensation, coronary insufficiency, cardiac arrhythmias. (nih.gov)
Concentration1
- Researchers believe that the current definition ignores urinary citrate concentration, which may be far more important than the gross total 24-hour urinary citrate excretion. (medscape.com)
Clinical1
- PACIFICI, G.M. Clinical pharmacology of caffeine citrate in preterm infants. (bvsalud.org)
Relax1
- Orphenadrine citrate does not directly relax tense muscles in man. (nih.gov)
Levels4
- Further, they argue that optimal urinary citrate levels for calcium stone formers are likely to be closer to the statistical average or median of the reference group than to the lower limits of the healthy range. (medscape.com)
- Using this logic, optimal daily urinary citrate levels for calcium stone formers would probably range from 500-800 mg, and one group uses 450 mg/d in men and 550 mg/d in women as cutoff values in stone formers. (medscape.com)
- This process is pH-dependent, and increases in urinary pH levels appear to be more important in the formation of this complex than are increases in available citrate per se. (medscape.com)
- calcium citrate decreases levels of eltrombopag by inhibition of GI absorption. (medscape.com)
Formula1
- The addition of citrate on Eversoft TM formula had an impact on all properties evaluated, however, after surface sealer appliance Eversoft presented better properties, and surface roughness and sorption of both groups did not differ statistically. (bvsalud.org)
Health1
- There has been considerable investigation into the health benefits of calcium citrate malate (CCM) since it was first patented in the late 1980s. (nih.gov)
Salt2
- Orphenadrine citrate is the citrate salt of orphenadrine. (nih.gov)
- Citrate in the urine has long been recognized as an inhibitor of calcium salt crystallization. (medscape.com)
Effect2
- calcium citrate will increase the level or effect of amantadine by Other (see comment). (medscape.com)
- The 20nm citrate particles showed the greatest effect, increasing lung macrophages even 21 d after exposure, and resulted in the greatest silver retention in lung tissue. (cdc.gov)
Addition2
- [ 3 ] In addition, urinary citrate excretion can increase urinary pH, which is a factor in uric acid crystallization and uric acid stone formation, as well as in the calcium-citrate-phosphate complex formation described above. (medscape.com)
- In addition to calcium citrate, calcium carbonate is also common. (dotfit.com)
Effects3
- Efficacy, measured as circuit survival, and secondary effects of heparin and citrate were compared. (hindawi.com)
- calcium citrate decreases effects of acebutolol by unspecified interaction mechanism. (medscape.com)
- calcium citrate decreases effects of amlodipine by pharmacodynamic antagonism. (medscape.com)
People1
- While hypocitraturia currently is defined as the excretion of less than 320 mg of citrate per day, most healthy people actually will have daily urinary citrate excretions of over 600 mg. (medscape.com)
Size1
- Adult male rats were intratracheally instilled with four different AgNPs: 20 or 110nm in size and coated with either citrate or polyvinylpyrrolidone (PVP) at 0.5 or 1.0 mg/kg doses. (cdc.gov)
Patients10
- Orphenadrine citrate extended-release tablets are contraindicated in patients with glaucoma, pyloric or duodenal obstruction, stenosing peptic ulcers, prostatic hypertrophy or obstruction of the bladder neck, cardio-spasm (mega-esophagus) and myasthenia gravis. (nih.gov)
- Orphenadrine citrate tablets are contraindicated in patients who have demonstrated a previous hypersensitivity to the drug. (nih.gov)
- 12 patients on CRRT with citrate anticoagulation and 24 patients with heparin anticoagulation were analyzed. (hindawi.com)
- In the citrate group, 45.5% of patients developed hypochloremia and 27.3% hypomagnesemia. (hindawi.com)
- Three patients were moved from heparin to citrate to control postoperatory bleeding. (hindawi.com)
- Regional anticoagulation with citrate has been proposed for critically ill patients for whom systemic anticoagulation is discouraged. (hindawi.com)
- However, few observational studies have been published about citrate anticoagulation in pediatric patients [ 3 , 4 ] and no one has compared the efficacy of heparin and citrate for anticoagulation in critically ill children on CRRT. (hindawi.com)
- We included all patients treated with citrate. (hindawi.com)
- To improve statistical power each patient treated with citrate was coupled with two patients treated with heparin that used the same type of filter. (hindawi.com)
- Catheters between 4 F and 11 F were used depending on the age and weight of the child, using the same criteria for patients treated with citrate and heparin anticoagulation: 5 F dual-lumen catheters were used in children weighing less than 5 kg, 6.5 F dual-lumen catheters in patients between 5 and 15 kg, and 8 F to 11 F catheters in patients weighing over 15 kg. (hindawi.com)
Include1
- Other definitions include a urine citrate level of less than 220 mg per day for both men and women, regardless of age, or less than 115 mg per day in men and less than 200 mg per day in women. (medscape.com)