A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).
The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)
A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.
A publication issued at stated, more or less regular, intervals.
The most common form of fibrillar collagen. It is a major constituent of bone (BONE AND BONES) and SKIN and consists of a heterotrimer of two alpha1(I) and one alpha2(I) chains.
Copies of a work or document distributed to the public by sale, rental, lease, or lending. (From ALA Glossary of Library and Information Science, 1983, p181)
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
Extensive collections, reputedly complete, of references and citations to books, articles, publications, etc., generally on a single subject or specialized subject area. Databases can operate through automated files, libraries, or computer disks. The concept should be differentiated from DATABASES, FACTUAL which is used for collections of data and facts apart from bibliographic references to them.
The premier bibliographic database of the NATIONAL LIBRARY OF MEDICINE. MEDLINE® (MEDLARS Online) is the primary subset of PUBMED and can be searched on NLM's Web site in PubMed or the NLM Gateway. MEDLINE references are indexed with MEDICAL SUBJECT HEADINGS (MeSH).
The profession of writing. Also the identity of the writer as the creator of a literary production.
A family of structurally related collagens that form the characteristic collagen fibril bundles seen in CONNECTIVE TISSUE.
Activities performed to identify concepts and aspects of published information and research reports.
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
Controlled vocabulary thesaurus produced by the NATIONAL LIBRARY OF MEDICINE. It consists of sets of terms naming descriptors in a hierarchical structure that permits searching at various levels of specificity.
A non-fibrillar collagen found in the structure of BASEMENT MEMBRANE. Collagen type IV molecules assemble to form a sheet-like network which is involved in maintaining the structural integrity of basement membranes. The predominant form of the protein is comprised of two alpha1(IV) subunits and one alpha2(IV) subunit, however, at least six different alpha subunits can be incorporated into the heterotrimer.
A fibrillar collagen consisting of three identical alpha1(III) chains that is widely distributed in many tissues containing COLLAGEN TYPE I. It is particularly abundant in BLOOD VESSELS and may play a role in tissues with elastic characteristics.
Discussion of lists of works, documents or other publications, usually with some relationship between them, e.g., by a given author, on a given subject, or published in a given place, and differing from a catalog in that its contents are restricted to holdings of a single collection, library, or group of libraries. (from The ALA Glossary of Library and Information Science, 1983)
Collagen receptors are cell surface receptors that modulate signal transduction between cells and the EXTRACELLULAR MATRIX. They are found in many cell types and are involved in the maintenance and regulation of cell shape and behavior, including PLATELET ACTIVATION and aggregation, through many different signaling pathways and differences in their affinities for collagen isoforms. Collagen receptors include discoidin domain receptors, INTEGRINS, and glycoprotein VI.
A fibrillar collagen found predominantly in CARTILAGE and vitreous humor. It consists of three identical alpha1(II) chains.
The evaluation by experts of the quality and pertinence of research or research proposals of other experts in the same field. Peer review is used by editors in deciding which submissions warrant publication, by granting agencies to determine which proposals should be funded, and by academic institutions in tenure decisions.
The collection, writing, and editing of current interest material on topics related to biomedicine for presentation through the mass media, including newspapers, magazines, radio, or television, usually for a public audience such as health care consumers.
Research that involves the application of the natural sciences, especially biology and physiology, to medicine.
Organized activities related to the storage, location, search, and retrieval of information.
A non-fibrillar collagen that forms a network of MICROFIBRILS within the EXTRACELLULAR MATRIX of CONNECTIVE TISSUE. The alpha subunits of collagen type VI assemble into antiparallel, overlapping dimers which then align to form tetramers.
Discussion of documents issued by local, regional, or national governments or by their agencies or subdivisions.
The guidelines and policy statements set forth by the editor(s) or editorial board of a publication.
The study of natural phenomena by observation, measurement, and experimentation.
A fibrillar collagen found widely distributed as a minor component in tissues that contain COLLAGEN TYPE I and COLLAGEN TYPE III. It is a heterotrimeric molecule composed of alpha1(V), alpha2(V) and alpha3(V) subunits. Several forms of collagen type V exist depending upon the composition of the subunits that form the trimer.
Books designed by the arrangement and treatment of their subject matter to be consulted for definite terms of information rather than to be read consecutively. Reference books include DICTIONARIES; ENCYCLOPEDIAS; ATLASES; etc. (From the ALA Glossary of Library and Information Science, 1983)
A biography which includes a list of the writings of the subject person.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
Historically, a heterogeneous group of acute and chronic diseases, including rheumatoid arthritis, systemic lupus erythematosus, progressive systemic sclerosis, dermatomyositis, etc. This classification was based on the notion that "collagen" was equivalent to "connective tissue", but with the present recognition of the different types of collagen and the aggregates derived from them as distinct entities, the term "collagen diseases" now pertains exclusively to those inherited conditions in which the primary defect is at the gene level and affects collagen biosynthesis, post-translational modification, or extracellular processing directly. (From Cecil Textbook of Medicine, 19th ed, p1494)
A meshwork-like substance found within the extracellular space and in association with the basement membrane of the cell surface. It promotes cellular proliferation and provides a supporting structure to which cells or cell lysates in culture dishes adhere.
Passing off as one's own the work of another without credit.
A biosynthetic precursor of collagen containing additional amino acid sequences at the amino-terminal and carboxyl-terminal ends of the polypeptide chains.
A non-fibrillar collagen found in BASEMENT MEMBRANE. The C-terminal end of the alpha1 chain of collagen type XVIII contains the ENDOSTATIN peptide, which can be released by proteolytic cleavage.
A hydroxylated form of the imino acid proline. A deficiency in ASCORBIC ACID can result in impaired hydroxyproline formation.
Those individuals engaged in research.
Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)
Published materials which provide an examination of recent or current literature. Review articles can cover a wide range of subject matter at various levels of completeness and comprehensiveness based on analyses of literature that may include research findings. The review may reflect the state of the art. It also includes reviews as a literary form.
Terms or expressions which provide the major means of access by subject to the bibliographic unit.
A fibrillar collagen found primarily in interstitial CARTILAGE. Collagen type XI is heterotrimer containing alpha1(XI), alpha2(XI) and alpha3(XI) subunits.
A computerized biomedical bibliographic storage and retrieval system operated by the NATIONAL LIBRARY OF MEDICINE. MEDLARS stands for Medical Literature Analysis and Retrieval System, which was first introduced in 1964 and evolved into an online system in 1971 called MEDLINE (MEDLARS Online). As other online databases were developed, MEDLARS became the name of the entire NLM information system while MEDLINE became the name of the premier database. MEDLARS was used to produce the former printed Cumulated Index Medicus, and the printed monthly Index Medicus, until that publication ceased in December 2004.
Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.
Using an INTERNET based personal journal which may consist of reflections, comments, and often hyperlinks.
An organized procedure carried out by a select committee of professionals in evaluating the performance of other professionals in meeting the standards of their specialty. Review by peers is used by editors in the evaluation of articles and other papers submitted for publication. Peer review is used also in the evaluation of grant applications. It is applied also in evaluating the quality of health care provided to patients.
The collection, preparation, and distribution of news and related commentary and feature materials through such media as pamphlets, newsletters, newspapers, magazines, radio, motion pictures, television, and books. While originally applied to the reportage of current events in printed form, specifically newspapers, with the advent of radio and television the use of the term has broadened to include all printed and electronic communication dealing with current affairs.
An agency of the NATIONAL INSTITUTES OF HEALTH concerned with overall planning, promoting, and administering programs pertaining to advancement of medical and related sciences. Major activities of this institute include the collection, dissemination, and exchange of information important to the progress of medicine and health, research in medical informatics and support for medical library development.
Authors' withdrawal or disavowal of their participation in performing research or writing the results of their study.
A hydroxylated derivative of the amino acid LYSINE that is present in certain collagens.
A non-vascular form of connective tissue composed of CHONDROCYTES embedded in a matrix that includes CHONDROITIN SULFATE and various types of FIBRILLAR COLLAGEN. There are three major types: HYALINE CARTILAGE; FIBROCARTILAGE; and ELASTIC CARTILAGE.
Works about clinical trials that involve at least one test treatment and one control treatment, concurrent enrollment and follow-up of the test- and control-treated groups, and in which the treatments to be administered are selected by a random process, such as the use of a random-numbers table.
Colloids with a solid continuous phase and liquid as the dispersed phase; gels may be unstable when, due to temperature or other cause, the solid phase liquefies; the resulting colloid is called a sol.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
A family of non-fibrillar collagens that interact with FIBRILLAR COLLAGENS. They contain short triple helical domains interrupted by short non-helical domains and do not form into collagen fibrils.
A darkly stained mat-like EXTRACELLULAR MATRIX (ECM) that separates cell layers, such as EPITHELIUM from ENDOTHELIUM or a layer of CONNECTIVE TISSUE. The ECM layer that supports an overlying EPITHELIUM or ENDOTHELIUM is called basal lamina. Basement membrane (BM) can be formed by the fusion of either two adjacent basal laminae or a basal lamina with an adjacent reticular lamina of connective tissue. BM, composed mainly of TYPE IV COLLAGEN; glycoprotein LAMININ; and PROTEOGLYCAN, provides barriers as well as channels between interacting cell layers.
A non-fibrillar collagen found primarily in terminally differentiated hypertrophic CHONDROCYTES. It is a homotrimer of three identical alpha1(X) subunits.
The study of those aspects of energy and matter in terms of elementary principles and laws. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Macromolecular organic compounds that contain carbon, hydrogen, oxygen, nitrogen, and usually, sulfur. These macromolecules (proteins) form an intricate meshwork in which cells are embedded to construct tissues. Variations in the relative types of macromolecules and their organization determine the type of extracellular matrix, each adapted to the functional requirements of the tissue. The two main classes of macromolecules that form the extracellular matrix are: glycosaminoglycans, usually linked to proteins (proteoglycans), and fibrous proteins (e.g., COLLAGEN; ELASTIN; FIBRONECTINS; and LAMININ).
An optical disk storage system for computers on which data can be read or from which data can be retrieved but not entered or modified. A CD-ROM unit is almost identical to the compact disk playback device for home use.
The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.
A list of works, documents, and other publications on medical subjects and topics of interest to the field of medicine.
The act or practice of literary composition, the occupation of writer, or producing or engaging in literary work as a profession.
Fibrous bands or cords of CONNECTIVE TISSUE at the ends of SKELETAL MUSCLE FIBERS that serve to attach the MUSCLES to bones and other structures.
Collection and analysis of data pertaining to operations of a particular library, library system, or group of independent libraries, with recommendations for improvement and/or ordered plans for further development.
Field of medicine concerned with the determination of causes, incidence, and characteristic behavior of disease outbreaks affecting human populations. It includes the interrelationships of host, agent, and environment as related to the distribution and control of disease.
Disciplines concerned with the interrelationships of individuals in a social environment including social organizations and institutions. Includes Sociology and Anthropology.
Organizations representing specialized fields which are accepted as authoritative; may be non-governmental, university or an independent research organization, e.g., National Academy of Sciences, Brookings Institution, etc.
Individual's rights to obtain and use information collected or generated by others.
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
A subspecialty of internal medicine concerned with the study of the physiology and diseases of the digestive system and related structures (esophagus, liver, gallbladder, and pancreas).
A fibril-associated collagen found in many tissues bearing high tensile stress, such as TENDONS and LIGAMENTS. It is comprised of a trimer of three identical alpha1(XII) chains.
A metalloproteinase which degrades helical regions of native collagen to small fragments. Preferred cleavage is -Gly in the sequence -Pro-Xaa-Gly-Pro-. Six forms (or 2 classes) have been isolated from Clostridium histolyticum that are immunologically cross-reactive but possess different sequences and different specificities. Other variants have been isolated from Bacillus cereus, Empedobacter collagenolyticum, Pseudomonas marinoglutinosa, and species of Vibrio and Streptomyces. EC 3.4.24.3.
Computer processing of a language with rules that reflect and describe current usage rather than prescribed usage.
Compositions written by hand, as one written before the invention or adoption of printing. A manuscript may also refer to a handwritten copy of an ancient author. A manuscript may be handwritten or typewritten as distinguished from a printed copy, especially the copy of a writer's work from which printed copies are made. (Webster, 3d ed)
Systems where the input data enter the computer directly from the point of origin (usually a terminal or workstation) and/or in which output data are transmitted directly to that terminal point of origin. (Sippl, Computer Dictionary, 4th ed)
Integrated set of files, procedures, and equipment for the storage, manipulation, and retrieval of information.
The circulation or wide dispersal of information.
A non-fibrillar collagen involved in anchoring the epidermal BASEMENT MEMBRANE to underlying tissue. It is a homotrimer comprised of C-terminal and N-terminal globular domains connected by a central triple-helical region.
The branch of medicine concerned with diseases, mainly of parasitic origin, common in tropical and subtropical regions.
Glycoproteins found on the surfaces of cells, particularly in fibrillar structures. The proteins are lost or reduced when these cells undergo viral or chemical transformation. They are highly susceptible to proteolysis and are substrates for activated blood coagulation factor VIII. The forms present in plasma are called cold-insoluble globulins.
Dissertations embodying results of original research and especially substantiating a specific view, e.g., substantial papers written by candidates for an academic degree under the individual direction of a professor or papers written by undergraduates desirous of achieving honors or distinction.
Formed from pig pepsinogen by cleavage of one peptide bond. The enzyme is a single polypeptide chain and is inhibited by methyl 2-diaazoacetamidohexanoate. It cleaves peptides preferentially at the carbonyl linkages of phenylalanine or leucine and acts as the principal digestive enzyme of gastric juice.
Simultaneous or successive publishing of identical or near- identical material in two or more different sources without acknowledgment. It differs from reprinted publication in that a reprint cites sources. It differs from PLAGIARISM in that duplicate publication is the product of the same authorship while plagiarism publishes a work or parts of a work of another as one's own.
Tissue that supports and binds other tissues. It consists of CONNECTIVE TISSUE CELLS embedded in a large amount of EXTRACELLULAR MATRIX.
Glycoproteins which have a very high polysaccharide content.
Extensive collections, reputedly complete, of facts and data garnered from material of a specialized subject area and made available for analysis and application. The collection can be automated by various contemporary methods for retrieval. The concept should be differentiated from DATABASES, BIBLIOGRAPHIC which is restricted to collections of bibliographic references.
Enzymes that catalyze the degradation of collagen by acting on the peptide bonds.
Intentional falsification of scientific data by presentation of fraudulent or incomplete or uncorroborated findings as scientific fact.
Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.
A protective layer of firm, flexible cartilage over the articulating ends of bones. It provides a smooth surface for joint movement, protecting the ends of long bones from wear at points of contact.
A family of structurally-related short-chain collagens that do not form large fibril bundles.
A microcomputer-based software package providing a user-friendly interface to the MEDLARS system of the National Library of Medicine.
Development of a library collection, including the determination and coordination of selection policy, assessment of needs of users and potential users, collection use studies, collection evaluation, identification of collection needs, selection of materials, planning for resource sharing, collection maintenance and weeding, and budgeting.
A non-fibrillar collagen originally found in DESCEMET MEMBRANE. It is expressed in endothelial cell layers and in tissues undergoing active remodeling. It is heterotrimer comprised of alpha1(VIII) and alpha2(VIII) chains.
Elements of limited time intervals, contributing to particular results or situations.
Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.
Large, noncollagenous glycoprotein with antigenic properties. It is localized in the basement membrane lamina lucida and functions to bind epithelial cells to the basement membrane. Evidence suggests that the protein plays a role in tumor invasion.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
A plan for collecting and utilizing data so that desired information can be obtained with sufficient precision or so that an hypothesis can be tested properly.
Historically, the treatment of disease by the administration of animal organs or their extracts (after Brown-Sequard). At present synthetic preparations substitute for the extracts of a gland. (From Stedman, 26th ed)
The application of scientific knowledge to practical purposes in any field. It includes methods, techniques, and instrumentation.
An approach of practicing medicine with the goal to improve and evaluate patient care. It requires the judicious integration of best research evidence with the patient's values to make decisions about medical care. This method is to help physicians make proper diagnosis, devise best testing plan, choose best treatment and methods of disease prevention, as well as develop guidelines for large groups of patients with the same disease. (from JAMA 296 (9), 2006)
The field of knowledge, theory, and technology dealing with the collection of facts and figures, and the processes and methods involved in their manipulation, storage, dissemination, publication, and retrieval. It includes the fields of COMMUNICATION; PUBLISHING; LIBRARY SCIENCE; and informatics.
Ratio of output to effort, or the ratio of effort produced to energy expended.
Financial support of research activities.
Libraries in which a major proportion of the resources are available in machine-readable format, rather than on paper or MICROFORM.
COLLAGEN DISEASES characterized by brittle, osteoporotic, and easily fractured bones. It may also present with blue sclerae, loose joints, and imperfect dentin formation. Most types are autosomal dominant and are associated with mutations in COLLAGEN TYPE I.
Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.
The influence of study results on the chances of publication and the tendency of investigators, reviewers, and editors to submit or accept manuscripts for publication based on the direction or strength of the study findings. Publication bias has an impact on the interpretation of clinical trials and meta-analyses. Bias can be minimized by insistence by editors on high-quality research, thorough literature reviews, acknowledgement of conflicts of interest, modification of peer review practices, etc.
Evaluation of biomedical technology in relation to cost, efficacy, utilization, etc., and its future impact on social, ethical, and legal systems.
The field of information science concerned with the analysis and dissemination of medical data through the application of computers to various aspects of health care and medicine.
A mixed-function oxygenase that catalyzes the hydroxylation of peptidyllysine, usually in protocollagen, to peptidylhydroxylysine. The enzyme utilizes molecular oxygen with concomitant oxidative decarboxylation of the cosubstrate 2-oxoglutarate to succinate. EC 1.14.11.4.
Research carried out by nurses, generally in clinical settings, in the areas of clinical practice, evaluation, nursing education, nursing administration, and methodology.
A non-essential amino acid that is synthesized from GLUTAMIC ACID. It is an essential component of COLLAGEN and is important for proper functioning of joints and tendons.
Publications in any medium issued in successive parts bearing numerical or chronological designations and intended to be continued indefinitely. (ALA Glossary of Library and Information Science, 1983, p203)
Reagent used as an intermediate in the manufacture of beta-alanine and pantothenic acid.
A small leucine-rich proteoglycan that interacts with FIBRILLAR COLLAGENS and modifies the EXTRACELLULAR MATRIX structure of CONNECTIVE TISSUE. Decorin has also been shown to play additional roles in the regulation of cellular responses to GROWTH FACTORS. The protein contains a single glycosaminoglycan chain and is similar in structure to BIGLYCAN.
A United States organization of distinguished scientists and engineers established for the purpose of investigating and reporting upon any subject of art or science as requested by any department of government. The National Research Council organized by NAS serves as the principal operating agency to stimulate and support research.
Adherence of cells to surfaces or to other cells.
A surgical specialty which utilizes medical, surgical, and physical methods to treat and correct deformities, diseases, and injuries to the skeletal system, its articulations, and associated structures.
Books used in the study of a subject that contain a systematic presentation of the principles and vocabulary of a subject.
Writings having excellence of form or expression and expressing ideas of permanent or universal interest. The body of written works produced in a particular language, country, or age. (Webster, 3d ed)
A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.
A non-fibrillar collagen found as a ubiquitously expressed membrane- associated protein. Type XIII collagen contains both collagenous and non-collagenous domains along with a transmembrane domain within its N-terminal region.
Health planning and resources development agencies which function in each health service area of the United States (PL 93-641).
Integrin alpha1beta1 functions as a receptor for LAMININ and COLLAGEN. It is widely expressed during development, but in the adult is the predominant laminin receptor (RECEPTORS, LAMININ) in mature SMOOTH MUSCLE CELLS, where it is important for maintenance of the differentiated phenotype of these cells. Integrin alpha1beta1 is also found in LYMPHOCYTES and microvascular endothelial cells, and may play a role in angiogenesis. In SCHWANN CELLS and neural crest cells, it is involved in cell migration. Integrin alpha1beta1 is also known as VLA-1 and CD49a-CD29.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Polymorphic cells that form cartilage.
Restoration of integrity to traumatized tissue.
The developmental entity of a fertilized chicken egg (ZYGOTE). The developmental process begins about 24 h before the egg is laid at the BLASTODISC, a small whitish spot on the surface of the EGG YOLK. After 21 days of incubation, the embryo is fully developed before hatching.
A surgical specialty concerned with the structure and function of the eye and the medical and surgical treatment of its defects and diseases.
Use of sophisticated analysis tools to sort through, organize, examine, and combine large sets of information.
Microscopy using polarized light in which phenomena due to the preferential orientation of optical properties with respect to the vibration plane of the polarized light are made visible and correlated parameters are made measurable.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.
Microscopy in which the object is examined directly by an electron beam scanning the specimen point-by-point. The image is constructed by detecting the products of specimen interactions that are projected above the plane of the sample, such as backscattered electrons. Although SCANNING TRANSMISSION ELECTRON MICROSCOPY also scans the specimen point by point with the electron beam, the image is constructed by detecting the electrons, or their interaction products that are transmitted through the sample plane, so that is a form of TRANSMISSION ELECTRON MICROSCOPY.
The relationships between symbols and their meanings.
A member of the metalloproteinase family of enzymes that is principally responsible for cleaving FIBRILLAR COLLAGEN. It can degrade interstitial collagens, types I, II and III.
A family of transmembrane glycoproteins (MEMBRANE GLYCOPROTEINS) consisting of noncovalent heterodimers. They interact with a wide variety of ligands including EXTRACELLULAR MATRIX PROTEINS; COMPLEMENT, and other cells, while their intracellular domains interact with the CYTOSKELETON. The integrins consist of at least three identified families: the cytoadhesin receptors(RECEPTORS, CYTOADHESIN), the leukocyte adhesion receptors (RECEPTORS, LEUKOCYTE ADHESION), and the VERY LATE ANTIGEN RECEPTORS. Each family contains a common beta-subunit (INTEGRIN BETA CHAINS) combined with one or more distinct alpha-subunits (INTEGRIN ALPHA CHAINS). These receptors participate in cell-matrix and cell-cell adhesion in many physiologically important processes, including embryological development; HEMOSTASIS; THROMBOSIS; WOUND HEALING; immune and nonimmune defense mechanisms; and oncogenic transformation.
Occupations of medical personnel who are not physicians, and are qualified by special training and, frequently, by licensure to work in supporting roles in the health care field. These occupations include, but are not limited to, medical technology, physical therapy, physician assistant, etc.
Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.
The transparent anterior portion of the fibrous coat of the eye consisting of five layers: stratified squamous CORNEAL EPITHELIUM; BOWMAN MEMBRANE; CORNEAL STROMA; DESCEMET MEMBRANE; and mesenchymal CORNEAL ENDOTHELIUM. It serves as the first refracting medium of the eye. It is structurally continuous with the SCLERA, avascular, receiving its nourishment by permeation through spaces between the lamellae, and is innervated by the ophthalmic division of the TRIGEMINAL NERVE via the ciliary nerves and those of the surrounding conjunctiva which together form plexuses. (Cline et al., Dictionary of Visual Science, 4th ed)
Time period from 2001 through 2100 of the common era.
Organized services to provide information on any questions an individual might have using databases and other sources. (From Random House Unabridged Dictionary, 2d ed)
A product formed from skin, white connective tissue, or bone COLLAGEN. It is used as a protein food adjuvant, plasma substitute, hemostatic, suspending agent in pharmaceutical preparations, and in the manufacturing of capsules and suppositories.
A subtype of transforming growth factor beta that is synthesized by a wide variety of cells. It is synthesized as a precursor molecule that is cleaved to form mature TGF-beta 1 and TGF-beta1 latency-associated peptide. The association of the cleavage products results in the formation a latent protein which must be activated to bind its receptor. Defects in the gene that encodes TGF-beta1 are the cause of CAMURATI-ENGELMANN SYNDROME.
A dental specialty concerned with the diagnosis and surgical treatment of disease, injuries, and defects of the human oral and maxillofacial region.
Educational institutions providing facilities for teaching and research and authorized to grant academic degrees.
Basic glycoprotein members of the SERPIN SUPERFAMILY that function as COLLAGEN-specific MOLECULAR CHAPERONES in the ENDOPLASMIC RETICULUM.
A mixed-function oxygenase that catalyzes the hydroxylation of a prolyl-glycyl containing peptide, usually in PROTOCOLLAGEN, to a hydroxyprolylglycyl-containing-peptide. The enzyme utilizes molecular OXYGEN with a concomitant oxidative decarboxylation of 2-oxoglutarate to SUCCINATE. The enzyme occurs as a tetramer of two alpha and two beta subunits. The beta subunit of procollagen-proline dioxygenase is identical to the enzyme PROTEIN DISULFIDE-ISOMERASES.
A method of comparing the cost of a program with its expected benefits in dollars (or other currency). The benefit-to-cost ratio is a measure of total return expected per unit of money spent. This analysis generally excludes consideration of factors that are not measured ultimately in economic terms. Cost effectiveness compares alternative ways to achieve a specific set of results.
The maximum stress a material subjected to a stretching load can withstand without tearing. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed, p2001)
Created 7 April 1992 as a result of the division of Yugoslavia.
Heteropolysaccharides which contain an N-acetylated hexosamine in a characteristic repeating disaccharide unit. The repeating structure of each disaccharide involves alternate 1,4- and 1,3-linkages consisting of either N-acetylglucosamine or N-acetylgalactosamine.
An enzyme oxidizing peptidyl-lysyl-peptide in the presence of water & molecular oxygen to yield peptidyl-allysyl-peptide plus ammonia & hydrogen peroxide. EC 1.4.3.13.
The quality or state of relating to or affecting two or more nations. (After Merriam-Webster Collegiate Dictionary, 10th ed)
Generating tissue in vitro for clinical applications, such as replacing wounded tissues or impaired organs. The use of TISSUE SCAFFOLDING enables the generation of complex multi-layered tissues and tissue structures.
Systematic organization, storage, retrieval, and dissemination of specialized information, especially of a scientific or technical nature (From ALA Glossary of Library and Information Science, 1983). It often involves authenticating or validating information.
A quantitative method of combining the results of independent studies (usually drawn from the published literature) and synthesizing summaries and conclusions which may be used to evaluate therapeutic effectiveness, plan new studies, etc., with application chiefly in the areas of research and medicine.
The lamellated connective tissue constituting the thickest layer of the cornea between the Bowman and Descemet membranes.
A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.
Data processing largely performed by automatic means.
An integrin alpha subunit that primarily combines with INTEGRIN BETA1 to form the INTEGRIN ALPHA2BETA1 heterodimer. It contains a domain which has homology to collagen-binding domains found in von Willebrand factor.
Detailed account or statement or formal record of data resulting from empirical inquiry.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
The process whereby PLATELETS adhere to something other than platelets, e.g., COLLAGEN; BASEMENT MEMBRANE; MICROFIBRILS; or other "foreign" surfaces.
The field of nursing care concerned with the promotion, maintenance, and restoration of health.
Value of all final goods and services produced in a country in one year.
A layer of vascularized connective tissue underneath the EPIDERMIS. The surface of the dermis contains innervated papillae. Embedded in or beneath the dermis are SWEAT GLANDS; HAIR FOLLICLES; and SEBACEOUS GLANDS.
The provision of monetary resources including money or capital and credit; obtaining or furnishing money or capital for a purchase or enterprise and the funds so obtained. (From Random House Unabridged Dictionary, 2d ed.)
Study of the principles and practices of library administration and services.
The profession concerned with the teeth, oral cavity, and associated structures, and the diagnosis and treatment of their diseases including prevention and the restoration of defective and missing tissue.
A specified list of terms with a fixed and unalterable meaning, and from which a selection is made when CATALOGING; ABSTRACTING AND INDEXING; or searching BOOKS; JOURNALS AS TOPIC; and other documents. The control is intended to avoid the scattering of related subjects under different headings (SUBJECT HEADINGS). The list may be altered or extended only by the publisher or issuing agency. (From Harrod's Librarians' Glossary, 7th ed, p163)
Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.
Services offered to the library user. They include reference and circulation.
Platforms that provide the ability and tools to create and publish information accessed via the INTERNET. Generally these platforms have three characteristics with content user generated, high degree of interaction between creator and viewer, and easily integrated with other sites.
Non-nucleated disk-shaped cells formed in the megakaryocyte and found in the blood of all mammals. They are mainly involved in blood coagulation.
Cyanogen bromide (CNBr). A compound used in molecular biology to digest some proteins and as a coupling reagent for phosphoroamidate or pyrophosphate internucleotide bonds in DNA duplexes.
A verbal or nonverbal means of communicating ideas or feelings.
A purely physical condition which exists within any material because of strain or deformation by external forces or by non-uniform thermal expansion; expressed quantitatively in units of force per unit area.
The field of information science concerned with the analysis and dissemination of data through the application of computers applied to the field of nursing.
The attachment of PLATELETS to one another. This clumping together can be induced by a number of agents (e.g., THROMBIN; COLLAGEN) and is part of the mechanism leading to the formation of a THROMBUS.
Cell growth support structures composed of BIOCOMPATIBLE MATERIALS. They are specially designed solid support matrices for cell attachment in TISSUE ENGINEERING and GUIDED TISSUE REGENERATION uses.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Statistical models of the production, distribution, and consumption of goods and services, as well as of financial considerations. For the application of statistics to the testing and quantifying of economic theories MODELS, ECONOMETRIC is available.
A family of zinc-dependent metalloendopeptidases that is involved in the degradation of EXTRACELLULAR MATRIX components.
A subspecialty of internal medicine concerned with the study of the RESPIRATORY SYSTEM. It is especially concerned with diagnosis and treatment of diseases and defects of the lungs and bronchial tree.
Time period from 1901 through 2000 of the common era.
The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
The study of the heart, its physiology, and its functions.
Collagen triple helix.[citation needed]. In 1956, Crick and Watson speculated on the structure of small viruses. They suggested ... A citation to Astbury's earlier X-ray diffraction work was one of only eight references in Franklin's first paper on DNA.[42] ... Crick and Wilkins first met at King's College[citation needed] and not, as erroneously recorded by two authors, at the ... Molecular model of a tRNA molecule.[citation needed] Crick predicted that such adaptor molecules might exist as the links ...
This article needs additional citations for verification. Please help improve this article by adding citations to reliable ... In 1978, Shrive et al. reported that the collagen fibers of the menisci are oriented in a circumferential pattern.[6] When a ... This section does not cite any sources. Please help improve this section by adding citations to reliable sources. Unsourced ... This is due to a piece of the torn cartilage preventing the normal functioning of the knee joint.[citation needed] ...
Throughout life, the cardiac collagen skeleton is remodeled. Where collagen is diminished by age, calcium is often deposited, ... Charles S. Peskin and David M. McQueen at the Courant Institute of Mathematical Sciences.[citation needed] ... In youth, this collagen structure is free of calcium adhesions and is quite flexible. With aging some calcium can accumulate on ... The cardiac skeleton consists of four bands of dense connective tissue, as collagen, that encircle the bases of the pulmonary ...
Vitamin C is essential for the synthesis of collagen fibers. collagen synthesis.[citation needed] Periodontium Periodontal ... The PDL collagen fibers are categorized according to their orientation and location along the tooth. The cells include ... The PDL appears as the periodontal space of 0.4 to 1.5 mm[citation needed] on radiographs, a radiolucent area between the ... It is the different composition of collagens which give various ECM functions and abilities. There is a mixture of thick and ...
According to the Journal Citation Reports, the journal has a 2016 impact factor of 7.400. "Collagen and Related Research". NLM ... The journal was established in 1981 as Collagen and Related Research and renamed to Matrix: Collagen and Related Research in ... CS1 maint: discouraged parameter (link) "Matrix : Collagen and Related Research". NLM Catalog. United States National Library ... CS1 maint: discouraged parameter (link) "Matrix Biology". 2016 Journal Citation Reports. Web of Science (Sciences ed.). Thomson ...
As diverticulosis occurs in an older population such complications are serious events.[citation needed] ... Diverticular disease is more common in collagen disorders such as Ehlers Danlos Syndrome.[25] ... Treatments, like some colon cleansers, that cause hard stools, constipation, and straining, are not recommended.[citation ...
The circumferential arrangement of collagen surrounding the vein makes it susceptible to such tearing.[citation needed] ... A CT scan or MRI scan will usually detect significant subdural hematomas.[citation needed] ... Micrograph of a chronic subdural hematoma, as demonstrated by thin strands of collagen and neovascularization. HPS stain ... Matrix metalloproteinases remove surrounding collagen, providing space for new blood vessels to grow.[12] ...
reported that the collagen fibers of the menisci are oriented in a circumferential pattern. When a compressive force is applied ... The medial meniscus may shift a few millimeters, while the less stable lateral meniscus may move at least 1 cm.[citation needed ... This is due to a piece of the torn cartilage preventing the normal functioning of the knee joint.[citation needed] Degenerative ... The other meniscus rests on the lateral tibial plateau; this is the lateral meniscus.[citation needed] These menisci act to ...
Collagen swelling due to the alkaline pH. Collagen fibre bundle splitting. Removal of natural grease and fats Liming operations ... citation needed] The interfibrillary proteins are denatured by the presence of alkali (particularly sodium sulfide), rendered ...
Anti-ageing supplements are used to treat skin ageing.[citation needed] Photoageing has two main concerns: an increased risk ... Biochemically pigs contain dermal collagen and elastic content that is more similar to humans than other laboratory animals. ... Vitamin C is an antioxidant that regulates collagen synthesis, forms barrier lipids, regenerates vitamin E, and provides ... Cortisol causes degradation of collagen, accelerating skin ageing. ...
Another route would be to take collagen regulation drugs. As of 2006 it is unclear which antibodies will best treat connective ... Diagnostic testing includes screening for the positive antinuclear antibody.[citation needed] There is no current cure. The ... In most cases it is observed that the disease involves an overproduction of collagen. Diagnosis is by skin tests. Typically, ...
A fibroblast is a type of biological cell that synthesizes the extracellular matrix and collagen, produces the structural ... Tissue damage stimulates fibrocytes and induces the production of fibroblasts.[citation needed] Besides their commonly known ... Fibroblasts make collagen fibres, glycosaminoglycans, reticular and elastic fibers. Growing individuals' fibroblasts are ... citation needed] In view of the clinical application of stem cell derived tissues, the use of human fibroblast as feeders has ...
... citation needed] Thermotherapy increase the extensibility of collagen tissues. Using heat, it can relieve the stiffness in ... Heat therapy can be used for the treatment of headaches and migraines.[citation needed] Many people who suffer from chronic ... In order to achieve heat therapy for headaches, many use microwaveable pads[citation needed] which can often overheat, ... The therapeutic effects of heat include increasing the extensibility of collagen tissues; decreasing joint stiffness; reducing ...
It is also clear that both angioplasty and bypass interventions do not prevent future heart attack.[citation needed] The older ... The main structural proteins are collagen and elastin. This causes thinning and the wall balloons allowing gross enlargement to ... At the end of approximately six years of follow-up, CIMT measurements were correlated with cardiovascular events.[citation ... Atheroma is the pathological basis for the disease entity atherosclerosis, a subtype of arteriosclerosis.[citation needed] For ...
Type IV collagen '112' type is found in both vertebrates and invertebrates, and is the major isoform in most human basement ... Genetic testing is now a better alternative if kidney biopsy is not possible.[citation needed] A family history of end-stage ... Since type IV collagen is found in the ears, eyes, and kidneys, this explains why Alport syndrome affects different seemingly ... When mutations prevent the formation of 345 type IV collagen network in the glomerulus, the 112 network, which is formed in ...
Stroma is rich in collagen and/or myxoid ground substance. Low mag. Intermed. mag. Goldner, 400x Surgical excision is usually ... Local recurrence has been described after simple surgical excision but it is rare.[citation needed] Histologically vast array ...
". "Farhad Hafezi, MD PhD - Google Scholar Citations". scholar.google.com. Retrieved 2019-04-24. 1. Corneal collagen cross- ... 2. Hafezi F, Mavrakanas N Corneal Collagen Cross-Linking for Postoperative Corneal Ectasia, in Corneal collagen cross-linking, ... His work in the field of corneal collagen cross-linking has led him to receive a number of international awards.[which?] In ... Sandvik GF; Drolsum L.; Thorsrud A; Råen M; Østern AE; Sæthre M (2015). "Does Corneal Collagen Cross-linking Reduce the Need ...
If the body does not destroy the improper collagen, the relationship between the collagen fibrils and hydroxyapatite crystals ... citation needed] In these varied cases, the total number of OIs of all four types was roughly the same as any other ethnicity. ... Recessive forms of OI relate heavily to defects in the collagen chaperones responsible for production of pro-collagen and the ... Collagen is not of a sufficient quality or quantity. *Most cases die within the first year of life due to respiratory failure ...
The bodies that are formed in this way move slightly with eye movement, but then return to their fixed position.[citation ... The collagen breaks down into fibrils, which ultimately are the floaters that plague the patient. ... The solid portion consists of a network of collagen and hyaluronic acid, with the latter retaining water molecules. ... The latter is an anomaly of the vitreous humour, whereby calcium clumps attach themselves to the collagen network. ...
Cartilage associated protein is involved in post translation modifications of collagen.[citation needed] The diagnosis may be ... It is made by sequencing the P4HB, SEC24D and CRTAP genes.[citation needed] Pfeiffer syndrome Osteogenesis imperfecta ... Features of this condition include[citation needed] Short trunk Poor growth Hydrocephalus Multiple fractures Craniofacial ... citation needed] This condition was first described in 1987. Cole DEC, Carpenter, TO (1987) Bone fragility, craniosynostosis, ...
It was first described by the Swiss surgeon Carl Garré.[citation needed] Belli E, Matteini C, Andreano T (November 2002). " ... It is a chronic osteomyelitis with subperiosteal bone and collagen deposition. There is no suppuration and sinus formation. ...
Non-ferrous pigments have also been known to cause burns during an MRI[citation needed]. It should be stressed that tattoo ... Other conditions noted have been cement dermatitis, collagen deposits, discoid lupus erythematosus, eczematous eruptions, ...
Citation plc of Knutsford, Cheshire Management systems to enable for sMEs to comply with. Contact Lens Precision Laboratories ... Biocolor Ltd of Newtownabbey, County for rapid, easy-to-use, collagen assay. Bradley Doublelock Ltd of Bingley, West Yorkshire ...
... citation needed] Underlying areas of cholesterol crystals[citation needed] Calcification at the outer base of older or more ... The bulk of these lesions is made of excess fat, collagen, and elastin. At first, as the plaques grow, only wall thickening ... The trial was published in JAMA in early 2006.[citation needed] Ongoing work starting in the 1990s may lead to human clinical ... To properly protect unsaturated fats from oxidation, it is best to keep them cool and in oxygen-free environments.[citation ...
... defects in the gene encoding the a4 chain of type IV collagen have been reported in some families.[citation needed] Overall, ... The history and presentation are helpful in this regard:[citation needed] In Alport syndrome, there is often a family history ... GeneReviews/NCBI/NIH/UW entry on Collagen IV-Related Nephropathies (Alport Syndrome and Thin Basement Membrane Nephropathy). ... Treating co-existing hypercalciuria and hyperuricosuria will also be helpful in reducing hematuria.[citation needed] The ...
Further, two independent networks are formed within the basal membrane by collagen IV and laminin for structural support. Other ... It has been shown to promote differentiation of neural stem cells into astrocytes.[citation needed] A monoclonal antibody, MR16 ... These cells help stimulate angiogenesis and collagen secretion into the injured area. Ultimately, the amount of capillaries ... citation needed] On the other hand, absence of the glial scar has been associated with impairments in the repair of the blood ...
2014). "Using a collagen matrix implant (Ologen) versus mitomycin-C as a wound healing modulator in trabeculectomy with the Ex- ... PMID 1748546.[permanent dead link] http://www.glaucoma.org.nz/memberFiles/Eyelights11-05.pdf[full citation needed] Lewis RA ( ... Rho, S; Sung Y; Ma KT; Rho SH; Kim CY (2015). "Bleb Analysis and Short-Term Results of Biodegradable Collagen Matrix-Augmented ... The ologen collagen matrix facilitates tissue regeneration and its application over the site of device implantation can ...
There also may be changes in the bones that show up on X-ray but generally are not a problem.[citation needed] The most severe ... Some families with Stickler syndrome have been shown to have mutations in the Type II collagen gene on chromosome 1. However, ... Majava, Marja (2007). Molecular genetics of Stickler and Marshall syndromes, and the role of collagen II and other candidate ... citation needed] The facial features of Marshall Syndrome include a flat midface, the appearance of large eyes, short upturned ...
This article needs additional citations for verification. Please help improve this article by adding citations to reliable ... and type III collagen is largely replaced by type I. Collagen which was originally disorganized is cross-linked and aligned ... Since ischaemia and most toxins do not destroy collagen, it will continue to exist even when the cells around it are dead. ... Cells also need a collagen framework along which to grow. Alongside most cells there is either a basement membrane or a ...
Its serum level is independent of muscle mass, making more accurate at estimating GFR than creatinine serum levels.[citation ... These glycosylation products accumulate on the proteins of vessel wall collagen, forming an irreversible complex of cross- ... This exacerbates the dysfunction caused by the metabolic effects of hyperglycemia.[citation needed] ... This is accompanied by a steady decline in kidney function.[citation needed] ...
Wikipedia articles incorporating a citation from the 1911 Encyclopaedia Britannica with Wikisource reference ... and a connective tissue dermis consisting largely of collagen fibres and various cells allowing colour change.[22] Most of the ...
... medical citation needed] ... Corneal collagen cross-linking. Iris, ciliary body,. sclera, ...
This article needs additional citations for verification. Please help improve this article by adding citations to reliable ... syndrome is genetically inherited disorder that is thought to affect the encoding of the connective tissue protein's collagen ...
Possibly important to basement membrane architecture and tissue development, as a needed catalyst to make collagen IV.[37] ... citation needed] Together these eleven chemical elements (H, C, N, O, Ca, P, K, Na, Cl, S, Mg) make up 99.85% of the body.[ ... citation needed] There is not scientific consensus on whether chromium is an essential trace element. The United States and ... "Bromine Is an Essential Trace Element for Assembly of Collagen IV Scaffolds in Tissue Development and Architecture". Cell. 157 ...
It is based on the microfracture surgery with the application of a bi-layer collagen I/III membrane. The AMIC technique was ... It appears to be a simpler technique and resolves some of the issues of using Carticel under a periosteal patch.[citation ... The collagen membrane protects and stabilizes the MSCs released through microfracture and enhances their chondrogenic ... "Maci" or autologous cultured chondrocytes on porcine collagen membrane, is a treatment to correct cartilage defects in the knee ...
Mice that survive this initial onslaught go on to demonstrate an increase in lung collagen content, and decreased lung ... citation needed] Phosgene, notably used as a chemical weapon during World War I, is also used as an industrial reagent and ...
This was cut short by concerns about prion disease.[citation needed] An SOD-mimetic agent, TEMPOL, is currently in clinical ... insights into heparin and collagen binding". J. Mol. Biol. 388 (2): 310-26. doi:10.1016/j.jmb.2009.03.026. PMID 19289127.. ... For example, SOD is a highly effective experimental treatment of chronic inflammation in colitis.[citation needed] Treatment ... Hence, high levels of free radicals can cause damage to them and induce dysraphic anomalies (neural tube defects).[citation ...
... citation needed]. For this reason, 6-fingered dwarfism has been removed as an alternative name for this entry. This leaves ...
... as healthy collagen replaces the defective collagen with vitamin C repletion. Treatment can be orally or by intramuscular or ... 553 °C (1,027 °F)[citation needed]. SMILES. *. OC[[email protected]](O)[[email protected]]1OC(=O)C(O)=C1O ... including wound healing and collagen synthesis. In humans, vitamin C deficiency leads to impaired collagen synthesis, ... Hydroxylation allows the collagen molecule to assume its triple helix structure, and thus vitamin C is essential to the ...
Recent research has found that extra virgin olive oil can activate autophagy and is likely[citation needed] to be one of the ... Another study demonstrated that skeletal muscle fibres of collagen VI knockout mice showed signs of degeneration due to an ... the accumulation of damaged organelles in collagen VI deficient muscle fibres was prevented and cellular homeostasis was ... "Physical exercise stimulates autophagy in normal skeletal muscles but is detrimental for collagen VI-deficient muscles" ...
The addition of PDGF at specific time‐points has been shown to stabilise vasculature in collagen‐glycosaminoglycan scaffolds.[ ... citation needed]The first engineered dominant negative protein was designed to inhibit PDGF [29] ... The patch employs a collagen platform seeded with particles containing the genes needed for producing bone. In experiments, it ... accelerating extracellular matrix and collagen formation and thus reducing the time for the healing process to occur.[22] ...
Integrin ligands (collagens, fibrinogen, fibronectin, laminins, ICAM-1, ICAM-2, osteopontin, VCAM-1, vitronectin) ... citation needed] ...
However, studies show that removal of hyaluronan from tumors prevents tumor invasion.[citation needed] Hyaluronidases are also ... "Testicular hyaluronidase induces tubular structures of endothelial cells grown in three-dimensional collagen gel through a CD44 ...
Tumor necrosis factor (TNF) alpha increases collagen accuulation and proliferation in intestinal myofibrobasts via TNF Receptor ... citation needed] Such complicated signaling ensures that, whenever TNF is released, various cells with vastly diverse functions ... and conditions can all respond appropriately to inflammation.[citation needed] In animal models TNFα selectively kills ...
Another study demonstrated that skeletal muscle fibres of collagen VI knockout mice showed signs of degeneration due to an ... citation needed] Upon recognition, the substrate protein gets unfolded and it is translocated across the lysosome membrane with ... the accumulation of damaged organelles in collagen VI deficient muscle fibres was prevented and cellular homeostasis was ... "Physical exercise stimulates autophagy in normal skeletal muscles but is detrimental for collagen VI-deficient muscles" ...
Collagen IV is the more common usage, as opposed to the older terminology of "type-IV collagen".[citation needed] Collagen IV ... Collagen IV (ColIV or Col4) is a type of collagen found primarily in the basal lamina. The collagen IV C4 domain at the C- ... Also, collagen IV lacks the regular glycine in every third residue necessary for the tight, collagen helix. This makes the ... Serum Collagen IV concentrations correlate with hepatic tissue levels of collagen IV in subjects with alcoholic liver disease ...
Integrin ligands (collagens, fibrinogen, fibronectin, laminins, ICAM-1, ICAM-2, osteopontin, VCAM-1, vitronectin) ... Plates containing puromycin are stable for 1 month when stored at 4 [7]°C.[citation needed] ... Puromycin acts quickly and can kill up to 99% of nonresistant cells within 2 days.[citation needed] ... Deletion of the gene encoding the multidrug efflux pump Pdr5 sensitizes cells to puromycin.[citation needed] ...
This section possibly contains original research. Please improve it by verifying the claims made and adding inline citations. ... ", "Hydrolysis Of Collagen" and "Changes In Cooked Meat And The Cooking Of Meat", the volume rivals or exceeds the scope of ... Benjamin Thompson, Count Rumford (1753-1814) was one of the early pioneers in the science of food & cooking.[citation needed] ...
Integrin ligands (collagens, fibrinogen, fibronectin, laminins, ICAM-1, ICAM-2, osteopontin, VCAM-1, vitronectin) ... citation needed] IGF2 promotes granulosa cell proliferation during the follicular phase of the menstrual cycle, acting ...
This article needs additional citations for verification. Please help improve this article by adding citations to reliable ... Saad, Mohamed (Oct 1994). Low resolution structure and packing investigations of collagen crystalline domains in tendon using ... Instances are collagen[3] family of proteins, tendon, muscle proteins like actin, cell proteins like microtubules and many ...
This section needs additional citations for verification. Please help improve this article by adding citations to reliable ... Possibly collagen and/or citrullinated self proteins. Chronic arthritis, inflammation, destruction of articular cartilage and ...
He enlisted the service of Wagner-Jauregg in Kuhn's laboratory.[citation needed] In 1933,[chronology citation needed] Kuhn, ... Collagen cross-linking by applying riboflavin topically then shining UV light is a method to slow progression of corneal ... In 1923[chronology citation needed], Paul Gyorgy in Heidelberg was investigating egg-white injury in rats; the curative factor ... chronology citation needed], they called it Ovoflavin. The same group then isolated the same preparation (a growth-promoting ...
G. N. Ramachandran developed a triple-helical model of collagen using samples provided by the institute during his research in ... Pages with citations having bare URLs. *Use Indian English from April 2017 ... "50 years of collagen triple helix: a celebration of science". The International Union of Crystallography. Retrieved 17 August ...
This article needs additional citations for verification. Please help improve this article by adding citations to reliable ... Corneal collagen cross-linking. Iris, ciliary body,. sclera, and anterior chamber. *Glaucoma surgery: Trabeculectomy ...
... collagen IV, fibronectin and laminin. Binding to these antigens within the kidney could cause inflammation and complement ... Wikipedia articles needing page number citations from March 2017. *CS1 maint: DOI inactive as of January 2021 ...
This section needs additional citations for verification. Please help improve this article by adding citations to reliable ... and each cell is encased within its own endomysium of collagen fibers. Thus, the overall muscle consists of fibers (cells) that ...
Other common causes of hypertensive crises are autonomic hyperactivity such as pheochromocytoma, collagen-vascular diseases, ... citation needed] The lifetime risk for developing hypertension is 86-90% in females and 81-83% in males. ...
... citation needed] Air and water pollutants[citation needed], environmental toxins,[citation needed] conventional styling ... Proteolysis of collagen leads to elimination of the damaged cells and then to terminal hair follicle miniaturization. ... Although not completely understood,[citation needed] hair loss can have many causes: Pattern hair loss. Main article: Pattern ... It can also physically restrict hair growth or damage the hair cuticle[citation needed], leading to hair that is weakened and ...
This article needs additional citations for verification. Please help improve this article by adding citations to reliable ... The result is collagen breakdown, infiltrate accumulation as well as collagen breakdown in the periodontal ligament and ... Successful completion of board certification results in Diplomate status in the American Board of Periodontology.[citation ... Regular periodontal check ups are also necessary, every 3-6 months.[citation needed] ...
Collagen type III induced ex vivo thrombogenesis in humans: role of platelets and leukocytes in deposition of fibrin, ... Citation Context. ...instance, collagen-adherent platelets, in the absence of wall-derived TF, can induce fibrin deposition at ... Citation Context. ...an vary in vessel injury models. Useful complements to in vivo models are ex vivo flow champers that allow ... Citation Context. ...; Fax: +1 404 385 1397; E-mail: [email protected] 0006-355X/07/$17.00 2007 - IOS Press and the ...
In summary, mechanical restriction by type I collagen opposes the overall tumor-promoting effects of CAF, thus providing a ... Therapeutic targeting of tumor-promoting CAF mediators while preserving type I collagen may convert CAF from tumor promoting to ... These effects were opposed by myCAF-expressed type I collagen, which suppressed tumor growth by mechanically restraining tumor ... Tumor restriction by type I collagen opposes tumor-promoting effects of cancer-associated fibroblasts. ...
Type II collagen autoimmunity in animals and provocations leading to arthritis. Immunol Rev 1990; 118: 193-232.. Direct Link: ... The role of collagen antibodies in mediating arthritis [review]. Mod Rheumatol 2008; 18: 429-41.. *CrossRef, ... Disappearing collagen antibodies in early rheumatoid arthritis: correlation with disease progression. Lancet 1985; 2: 501-2.. * ... Genetic control of collagen-induced arthritis in a cross with NOD and C57BL/10 mice is dependent on gene regions encoding ...
High glucose stimulates hepatic stellate cells to proliferate and to produce collagen through free radical production and ... SEARCH BY CITATION. Volume:. Issue:. Page:. ARTICLE TOOLS. *Get PDF (271K)Get PDF (271K) ... High glucose stimulates hepatic stellate cells to proliferate and to produce collagen through free radical production and ...
Collagen is a protein that plays an important protective role in the body. It is very strong and it has both clinical and ... Citations Please use one of the following formats to cite this article in your essay, paper or report:. MLA. McIntosh, James. " ... Collagen forms a scaffold to provide strength and structure. Endogenous collagen is natural collagen, synthesized by the body. ... With age, collagen weakens, leading to wrinkles and cartilage problems. In the dermis, or the middle layer of skin, collagen ...
Collagen intake can be increased through eating certain foods, such as citrus fruits. Topical creams with collagen are unlikely ... Collagen is a protein that is found throughout the body. One of its functions is to help skin cells renew and repair themselves ... Citations Please use one of the following formats to cite this article in your essay, paper or report:. MLA. Johnson, Jon. " ... What does collagen do for the skin?. As a person ages, their body produces less collagen. This lack of collagen results in the ...
PubMed journal article Effects of a proprietary topical medication on wound healing and collagen deposition in horse were found ... Related Citations. *Influence of wound shape on wound contraction in horses.. *Evaluation of a porous bovine collagen membrane ... Citation. Madison, J B., et al. "Effects of a Proprietary Topical Medication On Wound Healing and Collagen Deposition in Horses ... Effects of a Proprietary Topical Medication On Wound Healing and Collagen Deposition in Horses. Am J Vet Res. 1991;52(7):1128- ...
Current collagen‐polyester composite hydrogels consisting of pre‐formed polymeric particles encapsulated within a low ... Unlike the incorporation of pre‐formed particles, the new process allows for both improved physical properties of collagen ... The ease of fabrication, wide range of accessible compositions, and positive preliminary safety evaluations of these collagen‐ ... Herein, an amphiphilic composite platform associating dense collagen hydrogels and up to 50 wt% polyesters with different ...
... pro-collagen lipopeptide, creatine, and urea on skin aging signs. Download Prime PubMed App to iPhone, iPad, or Android ... Citation. Sanz, Maria Teresa, et al. "Biorevitalizing Effect of a Novel Facial Serum Containing Apple Stem Cell Extract, Pro- ... Related Citations. *Dermal penetration of creatine from a face-care formulation containing creatine, guarana and glycerol is ... TY - JOUR T1 - Biorevitalizing effect of a novel facial serum containing apple stem cell extract, pro-collagen lipopeptide, ...
In this work, a 3D analysis method is proposed for second harmonic generation images of collagen fibrils, based on a recently ... It brings the possibility to monitor remodelling of collagen tissues upon a variety of injuries and to guide tissues ... The recent booming of multiphoton imaging of collagen fibrils by means of second harmonic generation microscopy generates the ... Citation. Hellen Altendorf, Etienne Decencière, Dominique Jeulin, P. De Sa Peixoto, Ariane Deniset-Besseau, et al.. Imaging and ...
Download this article to citation manager. Shuster Sam, Black Martin M., Bottoms Eva. Skin Collagen and Thickness in Women with ... Total skin collagen is greatly increased in women with hirsuties. This is presumably due to androgen, whether locally produced ... If you are unable to import citations, please contact technical support for your product directly (links go to external sites): ... Skin Collagen and Thickness in Women with Hirsuties. Br Med J 1970; 4 doi: https://doi.org/10.1136/bmj.4.5738.772 (Published 26 ...
There are 29 genetically distinct collagens present in animal tissues. Collagen types I, II, III, V and XI self-assemble into D ... Here the D is approximately 67 nm and there is characteristic axial periodicity of collagen. These form the most abundant ... Citations Please use one of the following formats to cite this article in your essay, paper or report:. *. APA ... Type V collagen and type XI collagen are minor components of tissue and occur as fibrils with type I and type II collagen ...
Citation. Berg L, Lampa J, Rogberg S, et al. Increased peripheral T cell reactivity to microbial antigens and collagen type II ... Increased peripheral T cell reactivity to microbial antigens and collagen type II in rheumatoid arthritis after treatment with ... Increased peripheral T cell reactivity to microbial antigens and collagen type II in rheumatoid arthritis after treatment with ...
Type I collagen and hyaluronic acid are both the main components of bone extracellular matrix, and play important roles in ... Collagen V haploinsufficiency in a murine model of classic Ehlers-Danlos syndrome is associated with deficient structural and ... In this study, the synergistic effects of type I collagen (Col) and hyaluronic acid (HA) on the biological properties of Col/HA ... This study investigated the roles of collagen V in establishing structure and function in uninjured patellar tendons as well as ...
... collagen. Source for information on collagen disease: The Columbia Encyclopedia, 6th ed. dictionary. ... Learn more about citation styles Citation styles. Encyclopedia.com gives you the ability to cite reference entries and articles ... Encyclopedia.com cannot guarantee each citation it generates. Therefore, its best to use Encyclopedia.com citations as a ... or institution may have its own requirements for citations. Therefore, be sure to refer to those guidelines when editing your ...
Other Citations. * J20 line Further Reading. News. * SfN and More: Two Faces of TGF-β Revealed by Dead End Receptor 3 Nov 2006 ... However, the collagen VI-Aβ interaction seems more specific than that, since the researchers found that collagen I did not ... News Citations. * SfN and More: Two Faces of TGF-β Revealed by Dead End Receptor 3 Nov 2006. ... Collagen, a major component of connective tissues and extracellular matrices, is not the first thing that comes to mind when ...
Determination of Collagen and Elastin in Tissues. The Journal of Biological Chemistry, 186, 549-556. ... Article citations. More,,. Neuman, R.E. and Logan, M.A. (1950) Determination of Collagen and Elastin in Tissues. The Journal of ... The study indicates that availability of pure fish collagen could replace bovine collagen in tissue engineering applications. ... of collagen and thus confirmed the nativity and purity of the fish collagen. FT-IR studies confirmed the retention of all three ...
Citation. Shetty R, Nagaraja H, Jayadev C, et al. Collagen crosslinking in the management of advanced non-resolving microbial ...
Citation. Dua HS, Faraj LA, Branch MJ, et al. The collagen matrix of the human trabecular meshwork is an extension of the novel ... The collagen matrix of the human trabecular meshwork is an extension of the novel pre-Descemets layer (Duas layer) ... The collagen matrix of the human trabecular meshwork is an extension of the novel pre-Descemets layer (Duas layer) ...
Citation. GREGORY CA, ZABEL B, GRANT ME, et al. Equal expression of type X collagen mRNA from mutant and wild typeCOL10A1 ... Equal expression of type X collagen mRNA from mutant and wild typeCOL10A1 alleles in growth plate cartilage from a patient with ... Equal expression of type X collagen mRNA from mutant and wild typeCOL10A1 alleles in growth plate cartilage from a patient with ...
Citation. Yin O, Yu E, Cheng O, Zhang E, Gao A, Lin I, Han I, Zhu I, Beta-endorphin prevents collagen induced arthritis by ... 26 (6) 2005 Neuro endocrinology letters Comparative Study 2005; 26(6): 739-744 PubMed PMID: 16380673 Citation Keywords: ... Citation. Kern J, Geier D, Bjørklund G, King P, Homme K, Haley B, Sykes L, Geier M. Evidence supporting a link between dental ... Citation. Xiao J, Huang H, Peng Y, Bao J, Huang Y, Qiu Y. Modulation of natural killer cell function by alpha-adrenoreceptor- ...
Citation. Varki R, Sadowski S, Uitto J, et al. Epidermolysis bullosa. II. Type VII collagen mutations and phenotype-genotype ... Type VII collagen mutations and phenotype-genotype correlations in the dystrophic subtypes ... Type VII collagen mutations and phenotype-genotype correlations in the dystrophic subtypes ...
Citations to this Article [3 citations]. The following is the list of published articles that have cited the current article. ... Hyaluronan and Collagen in Human Hypertrophic Cardiomyopathy: A Morphological Analysis. Martin Hellström,1,2 Anna Engström- ...
Recommended Citation. Joshi, Rucha, "DESIGNER COLLAGEN-FIBRIL BIOGRAFT MATERIALS FOR TUNABLE MOLECULAR DELIVERY" (2016). Open ...
Download to a citation manager. Download the citation for this article by clicking on one of the following citation managers:. ...
... the collagen fibres are tilted out of the image plane. Both positive and negative areas of SHG-CD are observed in microscopy ... of collagen to occur. The SHG-CD can be observed with the microscope when: (i) the chiral second-order susceptibility tensor ... in particular collagen, and provides basis for the interpretation of SHG-CD signals. The nonlinear imaging of chiroptical ... Nonlinear optical properties of collagen type-I are investigated in thin tissue sections of pig tendon as a research model ...
... embedded in a collagen-rich extracellular matrix. Habitual mechanical loading or targeted exercise causes tendon cells to ... which in turn regulates mRNA translation and collagen expression. These results support a model in which integrins are an ... increase the stiffness of the extracellular matrix; this adaptation may occur in part through collagen synthesis or remodeling ... Zhang, Y. & Stefanovic, B. LARP6 meets collagen mRNA: Specific regulation of type I collagen expression. Int J Mol Sci 17 (2016 ...
Get Citation Copy Citation Text Shi-Wei Chu, Shih-Peng Tai, Ming-Che Chan, Chi-Kuang Sun, I-Ching Hsiao, Chi-Hung Lin, Yung- ... 3. Solid circles are measured F/B ratio relative to collagen fibril thickness. If the collagen molecules all act as active SHG ... 1. (A) AFM, (B) BSHG, and (C) FSHG images of a collagen fibril matrix on a cover glass. The selected fibril is marked with a ... E. Brown, T. McKee, E. diTomaso, A. Pluen, B. Seed, Y. Boucher, and R. K. Jain, "Dynamic imaging of collagen and its modulation ...
Get Citation Copy Citation Text Christophe Odin, Thomas Guilbert, Alia Alkilani, Olena P. Boryskina, Vincent Fleury, and Yann ... The ratio ρ=χ33/χ15 of the principal components of χ (2) of collagen and myosin was obtained with the same method, and found ... for sheep tendon collagen obtained from a 512×512 image acquired with an 60xW-NA1.2 objective; (b) Theoretical relationship Eq ... Table 1. Mean values of ρ for collagen and myosin. ,ρ, and σρ are respectively the mean and standard deviation of ρ calculated ...
Collagen triple helix.[citation needed]. In 1956, Crick and Watson speculated on the structure of small viruses. They suggested ... A citation to Astburys earlier X-ray diffraction work was one of only eight references in Franklins first paper on DNA.[42] ... Crick and Wilkins first met at Kings College[citation needed] and not, as erroneously recorded by two authors, at the ... Molecular model of a tRNA molecule.[citation needed] Crick predicted that such adaptor molecules might exist as the links ...
  • Some types of collagen fibrils, gram-for-gram, are stronger than steel. (medicalnewstoday.com)
  • In most collagens, the molecules are packed together to form long, thin fibrils. (medicalnewstoday.com)
  • Type 1 collagen fibrils are particularly capable of being stretched. (medicalnewstoday.com)
  • The recent booming of multiphoton imaging of collagen fibrils by means of second harmonic generation microscopy generates the need for the development and automation of quantitative methods for image analysis. (archives-ouvertes.fr)
  • In this work, a 3D analysis method is proposed for second harmonic generation images of collagen fibrils, based on a recently developed 3D fibre quantification method. (archives-ouvertes.fr)
  • Collagen types I, II, III, V and XI self-assemble into D-periodic cross-striated fibrils. (news-medical.net)
  • Type V collagen and type XI collagen are minor components of tissue and occur as fibrils with type I and type II collagen respectively. (news-medical.net)
  • Primary neuronal cultures from collagen α1(VI)-deficient mice were more susceptible to Aβ toxicity, as judged by increased cell death, and this susceptibility could be rescued by treating the neurons with collagen VI fibrils. (alzforum.org)
  • β1 integrin (also known as CD29) is a member of the subfamily of collagen-binding integrins (including α1β1, α2β1, α10β1 and α11β1) which bind to the triple-helical GFOGER sequence on collagen fibrils. (nature.com)
  • The nonlinear emission directions are strongly dependent on the coherent interaction within and between collagen fibrils. (osapublishing.org)
  • Collagen and myosin fibrils are endogenous harmonophores that both give rise to Second Harmonic Generation (SHG). (osapublishing.org)
  • Type I collagen, the predominant protein of vertebrates, assembles into fibrils that orchestrate the form and function of bone, tendon, skin, and other tissues. (jefferson.edu)
  • The structural response of collagen fibrils in pericardium and other tissues when subjected to strain and the effect of cross linking on those structural changes are not well understood. (rsc.org)
  • Under strain the collagen fibrils become much more oriented in the direction of the strain, with OI increasing from 0.25 to 0.89 in chondroitinase ABC-treated material, 0.22 to 0.93 in native material, and 0.22 to 0.77 in the glutaraldehyde-treated material. (rsc.org)
  • Glutaraldehyde cross links are, therefore, shown to constrain the collagen fibrils and link them together mechanically. (rsc.org)
  • NMR demonstrated that the OSA preferentially located to the termini of the procollagen fibrils, thereby templating the formation of apatitic calcium phosphate crystals within the collagen fibrils (as shown using TEM, EDX and SAED). (open.ac.uk)
  • Methods and devices are described for using a controlled extensional strain to organize prefibrillar collagen and/or elastin solutions into an organized array of fibrils. (freepatentsonline.com)
  • The organized array of collagen fibrils produced by the disclosed methods and devices can be used for tissue engineering applications. (freepatentsonline.com)
  • The peculiar hierarchical structure of the tendon, a highly anisotropic tissue, in which collagen fibrils assemble in parallel bundles, is difficult to restore since it is organized as an ensemble of structural units at increasing size levels, responsible for its remarkable biofunctional properties. (frontiersin.org)
  • Deposition of excessive amounts of collagens and abnormal cross-linking of collagen fibrils are associated with fibrosis. (sciencemag.org)
  • In human dermal fibroblasts (HDFs), TSP1 and collagen I colocalized in intracellular vesicles and on extracellular collagen fibrils, whereas TSP1 and proLOX colocalized only in intracellular vesicles. (sciencemag.org)
  • We here demonstrate directly, using live, dynamic, differential interference contrast imaging, that mechanically strained networks of collagen fibrils, exposed to collagenase ( Clostridium histolyticum ), degrade preferentially. (royalsocietypublishing.org)
  • The fibripositor model implies that cells individually direct the production and placement of collagen fibrils. (royalsocietypublishing.org)
  • ABSTRACT: A novel enzymatic method for extraction and preparation of fish collagen from swim bladder revealed the occurrence of α, β and γ bands with approximately 12.1 g/100g collagen corresponding to 89% of collagen and thus confirmed the nativity and purity of the fish collagen. (scirp.org)
  • Type III collagen is found in the walls of arteries and other hollow organs and usually occurs in the same fibril with type I collagen. (news-medical.net)
  • The small leucine-rich proteoglycans (SLRPs), decorin and biglycan, are key regulators of collagen fibril and matrix assembly. (bioquant.com)
  • To elucidate the type I collagen structure-function relationship, we constructed a type I collagen fibril interactome, including its functional sites and disease-associated mutations. (jefferson.edu)
  • The collagen fibril orientation index (OI) and D -spacing was measured on pericardium subjected to strain using synchrotron-based small angle X-ray scattering (SAXS). (rsc.org)
  • The OSA treatment of the collagen resulted in a structural change to the collagen fibres, modifying fibril diameter and changing the kinetics of fibre formation. (open.ac.uk)
  • Across the same age range, the volume of the fibril unit cell of corneal collagen ha.s been found to decrease. (open.ac.uk)
  • Regulatory mechanisms that act on collagen fibril assembly potentially offer new targets for antifibrotic treatments. (sciencemag.org)
  • Tissue weakening, altered collagen fibril morphologies, or both, are shared phenotypes of mice lacking matricellular thrombospondins. (sciencemag.org)
  • We found that TSP1 also affects collagen fibril formation directly. (sciencemag.org)
  • Collagen consists of amino acids bound together to form a triple helix of elongated fibril known as a collagen helix. (wikipedia.org)
  • Collagen is secreted by various cells, but mainly by connective tissue cells. (medicalnewstoday.com)
  • The ease of fabrication, wide range of accessible compositions, and positive preliminary safety evaluations of these collagen‐polyesters will favor their translation into clinics in wide areas such as drug delivery and tissue engineering. (archives-ouvertes.fr)
  • This is the collagen of granulation tissue, and is produced quickly by young fibroblasts before the tougher type I collagen is synthesized. (news-medical.net)
  • The study indicates that availability of pure fish collagen could replace bovine collagen in tissue engineering applications. (scirp.org)
  • Nonlinear optical properties of collagen type-I are investigated in thin tissue sections of pig tendon as a research model using a complete polarimetric second-harmonic generation (P-SHG) microscopy technique called double Stokes-Mueller polarimetry (DSMP). (nature.com)
  • The Tissue Train 3D Culture System (Flexcell International, USA) was used to apply uniaxial cyclic strain to the cells in a three-dimensional collagen-rich matrix, similar to in vivo tendon conditions. (nature.com)
  • When projected onto an X-ray diffraction model of the native collagen microfibril, data revealed a matrix interaction domain that assumes structural roles including collagen assembly, crosslinking, proteoglycan (PG) binding, and mineralization, and the cell interaction domain supporting dynamic aspects of collagen biology such as hemostasis, tissue remodeling, and cell adhesion. (jefferson.edu)
  • Type VI collagen makes up part of the extracellular matrix that surrounds muscle cells and connective tissue. (medlineplus.gov)
  • As a result, the stability of the surrounding muscle cells and connective tissue progressively declines, which leads to the muscle weakness, contractures, and other signs and symptoms of collagen VI-related myopathy. (medlineplus.gov)
  • Collagen is a structural component of the human body, as a connective tissue it can become altered as a result of pathophysiological conditions. (rsc.org)
  • Furthermore this technique can be extended to address challenges observed in collagen based tissue engineering and used as a minimally invasive diagnostic tool to characterise diseased and non-diseased collagen rich tissues. (rsc.org)
  • This too was found to increase with tissue age as did the production of fluorescent cross-links (possibly intermolecular) on the collagen. (open.ac.uk)
  • A process for extracting type I collagen from an avian source such as poultry feet that incorporates a fibrillar mass of connective tissue as well as bony tissue to yield a collagen product having useful medical and biotechnology applications. (google.co.uk)
  • The enzyme-treated comminuted material which is rich in collagen is dispersed in an organic acid to cause the fibrillar mass to undergo controlled swelling, after which the mass is separated from the bony tissue and purified to remove non-collangenous material. (google.co.uk)
  • An apparatus for controlled thermal shrinkage of collagen tissue by irradiation with coherent energy in the wavelength band of 1.80 to 2.55 microns as generated by a laser. (google.com)
  • An apparatus for shrinkage of collagen tissue by application. (google.com)
  • An apparatus for shrinkage of collagen tissue by application of coherent infrared energy, in which the threshold shrinkage temperature is substantially reduced by application of a reagent such as lysozyme to the tissue prior to heating. (google.com)
  • 1. Apparatus for shrinking collagen tissue, comprising means for applying a reagent to the tissue to reduce threshold shrinkage temperature, and means for irradiating the tissue with energy having a wavelength in a range of about 1.80 to about 2.55 microns. (google.com)
  • 2. Apparatus for shrinking collagen tissue, comprising means for applying a reagent to the tissue to reduce threshold shrinkage temperature, and means for irradiating the tissue with energy of infrared wavelength corresponding to corneal-collagen absorption coefficients in a range of about 15 to about 120 cm -1 . (google.com)
  • 7. Apparatus according to either claim 1 or claim 2 wherein the collagen tissue is corneal collagen tissue. (google.com)
  • 9. Apparatus according to either claim 1 or claim 2 wherein the irradiation means includes means for irradiating the tissue with energy such that the temperature of the collagen tissue is raised sufficiently to cause the tissue to shrink but not so high as to cause any substantial damage to the tissue. (google.com)
  • 10. Apparatus for modifying the shape of a cornea comprising means for applying a reagent to stromal collagen tissue of the cornea to reduce the threshold shrinkage temperature of the tissue to a range substantially above body temperature and below about 60 C., and means for irradiating the tissue with energy having a wavelength in a range of about 1.80 to 2.55 microns. (google.com)
  • Purifying human derived collagen from human tissue includes treating harvested human tissue with an enzyme to form a collagen product, deactivating the enzyme with a non-alkaline enzyme deactivation solution, and collecting the collagen product resulting from the enzyme treatment, where the collected. (google.co.uk)
  • This emphasizes the role of collagen in modulating cartilage mechanobiology in diseased tissue. (springer.com)
  • The researchers have found a simple new way to modify collagen, paving the way for better infection-fighting bandages and a treatment to block the formation of unwanted scar tissue. (newswise.com)
  • In addition, tissue engineers may be able to use modified collagen in the lab to help control the formation of tiny new blood vessels that can be used to promote the integration of tissue implants in patients. (newswise.com)
  • For example, collagen normally attracts cells to close up a wound and form scar tissue. (newswise.com)
  • This form of collagen could stop the formation of blood clots and scar tissue, and scientists may be able to use it to control the shape and organization of cells and tissue that are grown in a lab, Yu says. (newswise.com)
  • Gene expression of connective tissue growth factor (CTGF) and α1(I) collagen was determined by estimating mRNA levels using Northern analysis of B 1 stimulated cells. (ahajournals.org)
  • Collagen XXIII positivity in tissue samples correlates with the presence of adenocarcinoma and SqCC. (aacrjournals.org)
  • A, bar graph showing percentage of patient tumor or normal tissue cores expressing collagen XXIII across all NSCLC TMAs and each individual TMA. (aacrjournals.org)
  • Patients lacking detectable collagen XXIII staining in all of their representative tissue cores were considered negative for collagen XXIII protein expression (Supplementary Table S1). (aacrjournals.org)
  • Collagens, components of the extracellular matrix important for tissue architecture and function, undergo a complex series of processing events before and after secretion. (sciencemag.org)
  • We demonstrate that the commensal bacterium Enterococcus faecalis contributes to the pathogenesis of anastomotic leak through its capacity to degrade collagen and to activate tissue matrix metalloproteinase 9 (MMP9) in host intestinal tissues. (sciencemag.org)
  • There has been great interest in understanding the methods by which collagen-based load-bearing tissue is constructed, grown and maintained in vertebrate animals. (royalsocietypublishing.org)
  • However, given clear limitations in the ability of fibroblastic cells to precisely place or remove single collagen molecules to sculpt tissue, we have hypothesized that the material itself must play a critical role in the determination of the form of structural ECM. (royalsocietypublishing.org)
  • Serum Collagen IV concentrations correlate with hepatic tissue levels of collagen IV in subjects with alcoholic liver disease and hepatitis C and fall following successful therapy. (wikipedia.org)
  • Serum Markers for Hepatic Fibrosis in Alcoholic Liver Disease: Which is the Best Marker, Type III Procollagen, Type IV Collagen, Laminin, Tissue Inhibitor of Metalloproteinase, or Prolyl Hydroxylase? (wikipedia.org)
  • 3. The collagen composition of claim 1 wherein the collagen is a purified Type I collagen, purified Type III collagen, purified Type IV collagen, collagen rich tissue or a combination of the foregoing. (google.com.au)
  • 4. The collagen composition of claim 3 wherein the Type I collagen is derived from human tissue or animal tissue. (google.com.au)
  • 5. The collagen composition of claim 4 wherein the Type I collagen comprises autogenic human tissue. (google.com.au)
  • The present application relates to flowable collagen dural graft materials for repairing, replacing, reinforcing or strengthening bodily tissue, as an adhesion barrier, or for use as a short-term body contact for moisture retention, hemostasis or tissue protection. (google.com.au)
  • Collagen constitutes one to two percent of muscle tissue and accounts for 6% of the weight of strong, tendinous, muscles. (wikipedia.org)
  • Pathology of the collagen underpinning of the heart is understood within the category of connective tissue disease. (wikipedia.org)
  • Exogenous collagen is used for medical and cosmetic purposes, including the repair of body tissues. (medicalnewstoday.com)
  • Collagen occurs throughout the body, but especially in the skin, bones, and connective tissues. (medicalnewstoday.com)
  • It brings the possibility to monitor remodelling of collagen tissues upon a variety of injuries and to guide tissues engineering because biomimetic 3D organizations and density are requested for better integration of implants. (archives-ouvertes.fr)
  • There are 29 genetically distinct collagens present in animal tissues. (news-medical.net)
  • Type I collagen is found throughout the body except in cartilaginous tissues. (news-medical.net)
  • Collagen, a major component of connective tissues and extracellular matrices, is not the first thing that comes to mind when one thinks of nerve cells. (alzforum.org)
  • Neuman, R.E. and Logan, M.A. (1950) Determination of Collagen and Elastin in Tissues. (scirp.org)
  • Collagen is a major structural component of the extracellular matrix (ECM) in biological tissues and its structural organisation largely determines the mechanical and functional properties of tissues. (nature.com)
  • Tendons are specialized tissues composed primarily of load-responsive fibroblasts (tenocytes) embedded in a collagen-rich extracellular matrix. (nature.com)
  • This long-lived protein forms a major part of the human cornea and sclera and it is within these tissues that the work of this thesis has revealed age-related structural and biochemical modifications of type I collagen. (open.ac.uk)
  • Using the highly sensitive technique of X-ray diffraction, the size of the intermolecular unit cell of the collagen has been demonstrated to increase in both tissues from birth to 90 years of age. (open.ac.uk)
  • We used two-dimensional (2-D) Fourier analysis of transmission electron micrographs (TEMs) of the collagen arrays in the primate tissues to test whether these structural colours are produced by incoherent or coherent scattering (i.e. constructive interference). (biologists.org)
  • D, collagen XXIII staining is absent in SCLC tissues. (aacrjournals.org)
  • We demonstrate in rats that leaking anastomotic tissues were colonized by E. faecalis strains that showed an increased collagen-degrading activity and also an increased ability to activate host MMP9, both of which contributed to anastomotic leakage. (sciencemag.org)
  • In vertebrate animals, the load-bearing molecules of choice are fibrillar collagens (types I, II, III, V and XI), which can be found distributed extensively in the musculoskeletal system (bone, ligament, tendon, cartilage, intervertebral disc (IVD)) in skin and in highly specialized load-bearing tissues such as the cornea. (royalsocietypublishing.org)
  • The collagen compositions prepared accordingly can be used as medical adhesives for bonding soft tissues or be made in to a sealant film for a variety of medical uses such as wound closures and tendon wraps for preventing adhesion formation following surgery. (google.com.au)
  • Collagen (/ˈkɒlədʒən/) is the main structural protein in the extracellular matrix found in the body's various connective tissues. (wikipedia.org)
  • Depending upon the degree of mineralization, collagen tissues may be rigid (bone) or compliant (tendon) or have a gradient from rigid to compliant (cartilage). (wikipedia.org)
  • Type I collagen and hyaluronic acid are both the main components of bone extracellular matrix, and play important roles in regulating a cell's behavior. (bioquant.com)
  • The protection seems linked to weakening Aβ oligomer toxicity, since Cheng and colleagues found that the oligomers were sequestered into large aggregates that co-localized with collagen VI in the extracellular space. (alzforum.org)
  • So the way we picture this is that the neurons basically coat themselves, pouring the collagen into the extracellular milieu so that it can sequester the oligomers and prevent them from attacking," said Mucke. (alzforum.org)
  • Mechanical forces regulate extracellular matrix (ECM) synthesis and assembly of collagen fibers. (nature.com)
  • Research suggests that type VI collagen helps secure and organize the extracellular matrix by linking the matrix to the cells it surrounds. (medlineplus.gov)
  • Changes in type VI collagen structure or production lead to an unstable extracellular matrix that is no longer attached to cells. (medlineplus.gov)
  • To explore the effects of OP on cell metabolism, cell-associated and medium-secreted extracellular (CA and EC, respectively) collagen synthesis were measured by [ 3 H]proline incorporation. (ahajournals.org)
  • Conversely, it has been suggested that disruption of extracellular matrix collagen may be a primary mechanism for LV dilation, 6 and inadequate or disrupted fibrillar collagen at the site of infarction may lead to myocardial rupture. (ahajournals.org)
  • however, treatment of HDFs with KGHR-containing, TSP1-binding, triple-helical peptides disrupted the collagen-TSP1 association, perturbed the collagen extracellular matrix, and increased myofibroblastic differentiation in a manner that depended on TGF-β receptor 1. (sciencemag.org)
  • Thus, the extracellular KGHR-dependent interaction of TSP1 with fibrillar collagens contributes to fibroblast homeostasis. (sciencemag.org)
  • Among them, Ace (adhesin of collagen from E. faecalis ) plays an important role in adherence, presumably by mediating binding to extracellular matrix proteins, including both collagen and laminin ( 1 ). (asm.org)
  • The triple helical structure of collagen prevents it from being broken down by enzymes, it enables adhesiveness of cells and it is important for the proper assembly of the extracellular matrix. (wikipedia.org)
  • Collagen forms a scaffold to provide strength and structure. (medicalnewstoday.com)
  • The overall aim of the present study was to develop and characterise a reinforced natural scaffold using fibrin, collagen and glycosaminoglycan (FCG), and to examine the cell-mediated contraction of this scaffold in comparison to fibrin gels. (dit.ie)
  • Inspired by the success of generating multispectral imaging agents by using DNA as a scaffold for multichromophore assembly, the utilization of the distinctive self-assembly of collagen to template the arrangement of chromophores is also explored for the first time. (upenn.edu)
  • Porous BCP scaffolds with interconnected micropore structure were prepared with were prepared and then grafted with a collagen type I. The hydroxyapatite (HA) and beta-tricalcium phosphate (TCP) ratio of the TCP scaffolds was about 60/40 and the collagen was crosslinked on the TCP scaffold surface (collagen-TCP). (mendeley.com)
  • CONCLUSIONS: Collagen-BCP scaffold improved the cell attachment ability in early phase and osteoblastic differentiation. (mendeley.com)
  • Vascular endothelial growth factor (VEGF) was loaded on mesoporous silica nanoparticle (MSN), which was then incorporated within a type I collagen sponge, to produce collagen/MSN/VEGF (CMV) scaffold. (mendeley.com)
  • In the present work, we have evaluated the potential of a cell-free Collagen I-based scaffold to promote the augmentation of cartilage-like phenotype after subcutaneous implantation in the mouse. (frontiersin.org)
  • Collagen promotes blood clotting and provides the sponge-like scaffold upon which cells build nerves, bones and skin. (newswise.com)
  • Although the collagen degradation mechanism is not fully understood, it plays an important role in ageing, disease progression and applications in therapeutic laser treatments. (rsc.org)
  • The degradation and formation of collagen II can be monitored by the measurement of specific biomarkers in biologic fluids such as serum. (bioone.org)
  • In this study two commercially available immunoassays which measure a marker of collagen II degradation (C2C) and a marker of collagen II formation (CPII) were evaluated in Asian elephants. (bioone.org)
  • Conor P. Kilgallon , R. Scott Larsen , Alice Wong , and Clare Yellowley "ANALYSIS OF A COLLAGEN II DEGRADATION PROTEIN C2C AND A COLLAGEN II FORMATION PROTEIN CP II IN SERUM OF ASIAN ELEPHANTS ( ELEPHAS MAXIMUS )," Journal of Zoo and Wildlife Medicine 46(1), 146-149, (1 March 2015). (bioone.org)
  • Collagen degradation is one of the early signs of osteoarthritis. (springer.com)
  • It is not known how collagen degradation affects chondrocyte volume and morphology. (springer.com)
  • Thus, the aim of this study was to investigate the effect of enzymatically induced collagen degradation on cell volume and shape changes in articular cartilage after a hypotonic challenge. (springer.com)
  • MMP-2 expression was upregulated 1.5-fold in failing CF. In conclusion, our results suggest that β-arrestins play an important role in the regulation of collagen synthesis and degradation by CF. This occurs through GPCR (β-AR/cAMP) and GPCR-independent (TGF-β/ERK) mechanisms. (ahajournals.org)
  • There are at least 16 different types of collagen, but 80 to 90 percent of them belong to types 1, 2, and 3. (medicalnewstoday.com)
  • Mucke said that they have not yet tested other types of collagen (and there are many). (alzforum.org)
  • There are homo- and hetero-trimeric types of collagen consisting of one, two or three distinct chains. (rcsb.org)
  • However, as of 2011, 28 types of collagen have been identified, described, and divided into several groups according to the structure they form. (wikipedia.org)
  • Women experience a dramatic reduction in collagen synthesis after menopause . (medicalnewstoday.com)
  • this adaptation may occur in part through collagen synthesis or remodeling. (nature.com)
  • hc-Krox exerted a stimulating effect on type I collagen protein synthesis and enhanced the corresponding mRNA steady-state levels of COL1A1 and COL1A2 in foreskin fibroblasts (FF), adult normal fibroblasts (ANF), and scleroderma fibroblasts (SF). (jefferson.edu)
  • This observation, combined with normal or elevated baseline IGF-1 levels, supports both inhibition of IGF-1 effects and collagen synthesis as growth-retarding effects of glucocorticoid therapy. (aappublications.org)
  • In particular, the methods of the present invention comprise administering a composition comprising Chia Seed oil, Opuntia Ficus Indica extract, or both to stimulate collagen or hyaluronic acid synthesis, or decrease Interleukin-1b synthesis, in the skin. (freepatentsonline.com)
  • 1. A method for increasing collagen synthesis in a skin cell comprising administering a composition comprising Chia Seed oil to the skin cell, wherein the Chia Seed Oil induces collagen synthesis. (freepatentsonline.com)
  • 15. A method for improving the appearance of skin comprising administering a composition comprising Chia Seed oil, Opuntia Ficus extract, or both wherein the composition increases collagen synthesis, increases hyaluronic acid synthesis, or both. (freepatentsonline.com)
  • Collagen synthesis was measured by 14 C-proline incorporation. (diabetesjournals.org)
  • Myocardial collagen concentration and collagen synthesis was not altered in the diabetic rats. (diabetesjournals.org)
  • In subconfluent cultures, total CA and EC collagen synthesis was unaffected by OP, while in confluent cultures total EC collagen [ 3 H]proline incorporation was increased. (ahajournals.org)
  • Our data show that the high glucose growth stimulatory effect on cell number and DNA synthesis was suppressed by OP. Under high glucose conditions, total CA collagen synthesis was increased in confluent cultures, whereas the EC collagen fraction remained unchanged. (ahajournals.org)
  • In these cultures, OP caused an additional increase in CA collagen synthesis. (ahajournals.org)
  • This study shows that mesangial cell growth and collagen synthesis are influenced by hyperbaric OP, supporting the hypothesis that glomerular capillary pressure plays a role in progressive glomerulosclerosis development. (ahajournals.org)
  • Knockdown of β-arrestin 1 or 2 in failing CF led to increased β-agonist-stimulated cAMP production and restoration of β-agonist-mediated inhibition of collagen synthesis similar to normal CF. This effect was greater with decreased b-arrestin 2 expression. (ahajournals.org)
  • β-arrestin 1 knockdown led to a significant decline in TGF-β-stimulated collagen synthesis in normal and failing CF. This is likely mediated by decreased ERK 1/2 phosphorylation and activation which resulted from β-arrestin 1 knockdown. (ahajournals.org)
  • Interestingly, β-arrestin 2 knockdown did not have this effect, demonstrating specificity for regulating TGF-β-stimulated collagen synthesis. (ahajournals.org)
  • Cosmetic lotions that claim to increase collagen levels are unlikely to do so, as collagen molecules are too large to be absorbed through the skin. (medicalnewstoday.com)
  • These defects often cause problems in the biosynthesis of the collagen molecules, their assembly and posttranslational modification process that makes them their final end form of collagen. (news-medical.net)
  • The theoretical formalism and experimental validation of DSMP imaging technique opens new opportunities for ultrastructural characterisation of chiral molecules, in particular collagen, and provides basis for the interpretation of SHG-CD signals. (nature.com)
  • Yu's method, however, requires only physical mixing of collagen with even smaller molecules called collagen mimetic peptides. (newswise.com)
  • If you want to attach these molecules to collagen, you don't have to cook it or use harsh chemicals. (newswise.com)
  • They attached fluorescent tags to the peptides and observed the glow in collagen that had been mixed with the smaller molecules. (newswise.com)
  • But researchers know that collagen molecules form a distinctive triple-helix in which three long protein strands intertwine like rope. (newswise.com)
  • Yu speculates that because the smaller collagen mimetic peptides have a propensity to make similar triple-helix structures, they are naturally attracted to collagen molecules. (newswise.com)
  • In this study, we evaluated the efficacy and mechanism of recombinant MHC II molecules in regulation of the antigen-specific T cell clones by using mouse I-A q , combined with an auto-antigen peptide from type II collagen (CII260-274) in CIA model. (jimmunol.org)
  • TSP1 also bound to collagen molecules intracellularly and at conserved cross-linking sites. (sciencemag.org)
  • Our data highlights collagens as sentinel molecules for redox stress downstream of MAPK/Akt, and identifies intervention points to modulate the redox environment to target skin diseases and conditions associated with erroneous matrix deposition. (mcponline.org)
  • Thus, collagen molecules (together with their complement enzymes) may comprise the basis of a smart, load-adaptive, structural material system. (royalsocietypublishing.org)
  • The features are as follows (where D = 234 residues or 67 nm): (1) D -staggered collagen molecules 4.5 D long in the helical microfibril have a left-handed supercoil with a pitch of 400-700 residues, but microfibrils need not have helical symmetry. (portlandpress.com)
  • With age, collagen weakens, leading to wrinkles and cartilage problems. (medicalnewstoday.com)
  • Type II collagen is the main component of cartilage. (news-medical.net)
  • A Cartilage Growth Mixture Model With Collagen Remodeling: Validation " by Stephen M. Klisch, Anna Asanbaeva et al. (calpoly.edu)
  • Collagen II is a major component of articular cartilage. (bioone.org)
  • Fourier transform infrared microspectroscopy, polarized light microscopy, and mechanical testing were used to quantify differences in proteoglycan and collagen content, collagen orientation, and biomechanical properties, respectively, between the intact and degraded cartilage. (springer.com)
  • These findings suggest that the mechanical environment of chondrocytes, specifically collagen content and orientation, affects cell volume and shape changes in the superficial zone articular cartilage when exposed to osmotic loading. (springer.com)
  • Arokoski JPA, Hyttinen MM, Lapveteläinen T, Takacs P, Kosztaczky B, Modis L, Kovanen V, Helminen HJ (1996) Decreased birefringence of the superficial zone collagen network in the canine knee (stifle) articular cartilage after long distance running training, detected by quantitative polarised light microscopy. (springer.com)
  • Immunohistochemical analysis shows the expression of typical cartilage markers, including type-II Collagen, Aggrecan, Matrilin-1 and Sox 9. (frontiersin.org)
  • They found that addition of Aβ42 oligomers elevated Col6a1 mRNA and α1(VI) protein in primary hippocampal and cortical neurons, whereas the amyloid peptide had no effect on collagen production in astrocytes. (alzforum.org)
  • Repetitive stretching of tendon cells activates the AKT and mTOR pathways, which in turn regulates mRNA translation and collagen expression. (nature.com)
  • To approach the problem, we cloned a cDNA coding for the medaka collagen type-I α1 chain and examined its mRNA expression in the fish ovary. (bioone.org)
  • A comparison with the distribution of gelatinase B mRNA in follicles that had just ovulated indicated that the collagen type-I α1 gene is expressed in the theca cells. (bioone.org)
  • Maya Horiguchi , Chika Fujimori , Katsueki Ogiwara , Akihiko Moriyama , and Takayuki Takahashi "Collagen Type-I α1 Chain mRNA is Expressed in the Follicle Cells of the Medaka Ovary," Zoological Science 25(9), 937-945, (1 September 2008). (bioone.org)
  • This allowed us to quantitatively characterise the degraded area into four distinct zones: (1) depolymerised zone in the laser focal spot as indicated by the loss of SHG signal, (2) enhanced crosslinking zone in the inner boundary of the laser induced cavity as represented by the high fluorescence ring, (3) reduced crosslinking zone formed the outer boundary of the cavity as marked by the increased SHG signal and (4) native collagen. (rsc.org)
  • SCol(1/1) (grafting density of 17%) with self-assembly property and good hydrophilicity was chosen to compare with native collagen. (springer.com)
  • Compared to native collagen, thermostability of SCol(1/1) decreased slightly, however, SCol(1/1) could form softer hydrogel, which was more favorable for the proliferation of NIH/3 T3. (springer.com)
  • In the dermis, or the middle layer of skin, collagen helps form a fibrous network of cells called fibroblasts, upon which new cells can grow. (medicalnewstoday.com)
  • Human collagen Krox up-regulates type I collagen expression in normal and scleroderma fibroblasts through interaction with Sp1 and Sp3 transcription factors. (jefferson.edu)
  • We have investigated the role of hc-Krox transcription factor on type I collagen expression by human dermal fibroblasts. (jefferson.edu)
  • Transforming growth factor-β (TGF-β) stimulates fibrosis by promoting the differentiation of fibroblasts into collagen-secreting myofibroblasts, a process associated with alterations in cellular metabolism. (sciencemag.org)
  • Interfering with the mTOR-ATF4 axis reduced the incorporation of glucose-derived glycine into collagen in TGF-β 1 stimulated fibroblasts. (sciencemag.org)
  • Collagen scaffolds also support deposition of cells, such as osteoblasts and fibroblasts, and once inserted, facilitate growth to proceed normally. (wikipedia.org)
  • Several chemical compounds were also used to investigate the inhibition of in vitro glycation of collagen. (open.ac.uk)
  • Investigating the UV-hardening mechanism of collagen showed increased tyrosine crosslinks (dityrosines) in the in vitro model of photodamage to collagen, suggesting that dityrosine formation contributes to hardening and reduced elasticity of collagen in photoaged skin. (mdpi.com)
  • Spleen cells from the sST2-Fc-treated mice produced significantly less IFN-γ, TNF-α, IL-6, and IL-12 compared with cells from the control mice when cultured with collagen in vitro. (jimmunol.org)
  • In vitro, TSP1 bound to both the C-propeptide domain of collagen I and the highly conserved KGHR sequences of the collagen triple-helical domain that participate in cross-linking. (sciencemag.org)
  • Significantly increased IL-17 and IFNγ production was observed after stimulation of LN cells from TNFR-Fc-treated mice with collagen or anti-CD3 mAb in vitro, and a trend toward enhanced production of these cytokines was observed even in unstimulated LN cells ( Fig. 1 ). (rupress.org)
  • Interestingly, the invasive strains carried an additional gene, cnm , which was previously shown to bind to collagen and laminin in vitro . (asm.org)
  • Hence, detailed understanding of the structural properties of collagen is required to elucidate the details of collagen function and its role in disease-related processes. (nature.com)
  • Here, we uncover the structural basis for both chain selection and stagger formation of a collagen molecule. (rcsb.org)
  • Various medical implants can be formed using the isolated, enzymatically-treated human derived collagen having an amount of its natural collagen constituents preserved, and may include implantable sponges, patches, tubes, structural supports and coatings, and which may be used for repair, barrier, support and/or stabilization purposes. (google.co.uk)
  • The structural colours in Mandrillus rump and facial skin and Cercopithecus scrotum are produced by coherent scattering by quasi-ordered arrays of parallel dermal collagen fibres. (biologists.org)
  • To test the hypothesis that a P4H inhibitor could prevent cardiac fibrosis and produce favorable effects on LV function and structure after MI, we administered FG041 to rats for 4 weeks beginning 48 hours after experimental MI and evaluated collagen deposition as well as structural and functional changes in the LV. (ahajournals.org)
  • As fibrillar collagen provides the principal structural element for the myriad of diverse vertebrate forms, it is instructive to consider how it (as a potentially intelligent biomaterial) could enhance the ability of fibroblastic cells to produce organized, load-bearing structures over many length scales. (royalsocietypublishing.org)
  • This study aims at investigating the effects and molecular mechanism of riboflavin-ultraviolet-A-induced cross-linking (corneal collagen cross-linking, CXL) on corneal neovascularization (CNV) in a rabbit alkali burn model. (hindawi.com)
  • Our results indicate that riboflavin-ultraviolet-A-induced cross-linking (corneal collagen cross-linking, CXL) significantly inhibits alkali burn-induced CNV in rabbits, possibly through downregulating VEGF, MMP-2, MMP-9, and TIMP-1 expression. (hindawi.com)
  • The apparatus is especially useful in ophthalmology for shape modification of a cornea, and is enhanced by using a corneal collagen shield is provided as a carrier and delivery agent for the reagent and an admixed anaesthetic. (google.com)
  • Birk & Trelstad (1984) , while examining the development of nascent chick corneal structure, suggested that collagen is produced and organized within cell surface crypts or fibripositors. (royalsocietypublishing.org)
  • Collagen is the most abundant protein in the human body, found in the bones, muscles, skin, and tendons. (medicalnewstoday.com)
  • Collagen is a hard, insoluble, and fibrous protein that makes up one-third of the protein in the human body. (medicalnewstoday.com)
  • Collagen is an important protein, which the body needs to keep the skin looking young and healthy. (medicalnewstoday.com)
  • Collagen is the most common and abundant form of protein in the body. (medicalnewstoday.com)
  • The researchers came across the collagen connection while conducting microarray analysis for genes that are up- or downregulated in the dentate gyrus of transgenic mice expressing human amyloid precursor protein ( J20 line ). (alzforum.org)
  • They found that transcripts of the collagen VI α1 subunit (Col6a1) are elevated about fourfold in dentate gyrus of hAPP mice, while the α1(VI) protein was elevated nearly 20-fold. (alzforum.org)
  • Collagen is the most abundant protein in mammals, constituting almost a third of the total protein content in the body. (upenn.edu)
  • These genes each provide instructions for making one component of a protein called type VI collagen. (medlineplus.gov)
  • One such protein predominating throughout the body is collagen. (open.ac.uk)
  • One genomic locus that is believed to contribute to adherence is the fibronectin-binding, collagen-binding, T-antigen (FCT) region, primarily due to the inclusion of genes that encode for a pilus (tee18.1), collagen-binding protein (cpa), and fibronectin-binding protein (prtF2). (uwo.ca)
  • One particular genomic locus implicated in adhesion is the fibronectin-binding, collagen-binding, T-antigen (FCT) region, which notably encodes a pilus structure (tee18.1), a collagen-binding protein ( cpa ), and a fibronectin-binding protein ( prtF2 ). (uwo.ca)
  • Water is an important component of collagen in tendons, but its role for the function of this load-carrying protein structure is poorly understood. (mit.edu)
  • Traditionally, scientists have altered collagen by using intense heat or chemical reactions, techniques that may damage the protein or limit its safe use in humans. (newswise.com)
  • Furthermore, hyperglycemia was found to inhibit protein tyrosine phosphatase (PTP) activity and increase phosphorylation of the tyrosine kinase Syk in platelets exposed to collagen. (diabetesjournals.org)
  • Made with simple, real foods like nuts, egg white protein, and grass-fed beef collagen, the Collagen Bars are free from sugar alcohols and artificial ingredients. (thefreelibrary.com)
  • They contain 11 grams of protein, including 5 grams of grass-fed beef collagen, and are an excellent source of fiber at 5-6 grams per bar. (thefreelibrary.com)
  • The intermediate form of collagen VI-related myopathy is characterized by muscle weakness that begins in infancy. (medlineplus.gov)
  • While it is difficult to predict which type of mutation will lead to which form of collagen VI-related myopathy, in general, lower amounts of type VI collagen lead to more severe signs and symptoms that begin earlier in life. (medlineplus.gov)
  • Because the final common pathway for collagen formation involves the activity of P4H, inhibition of this enzyme after MI would be expected to prevent interstitial fibrosis. (ahajournals.org)
  • The aim of this study was to assess the impact of TNF inhibition on IL-17 production in collagen-induced arthritis, a model of RA. (rupress.org)
  • The real novelty is twofold," Mucke told ARF, "first that neurons produce collagen VI and second that they produce it to protect themselves from Aβ. (alzforum.org)
  • transmembrane collagen, interacts with integrin a1b1, fibronectin and components of basement membranes like nidogen and perlecan. (news-medical.net)
  • Type IV collagen is a major and crucial component of basement membranes. (pnas.org)
  • RASA1 was required for EC survival during developmental angiogenesis, because it was necessary for export of collagen IV from ECs and deposition in vascular basement membranes. (jci.org)
  • There are six human genes associated with it: COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6 The alpha-3 subunit (COL4A3) of collagen IV is thought to be the antigen implicated in Goodpasture syndrome, wherein the immune system attacks the basement membranes of the glomeruli and the alveoli upon the antigenic site on the alpha-3 subunit becomes unsequestered due to environmental exposures. (wikipedia.org)
  • The collagen IV C4 domain at the C-terminus is not removed in post-translational processing, and the fibers link head-to-head, rather than in parallel. (wikipedia.org)
  • Human collagen Krox up-regulates type I collagen expression in normal " by Magdalini Kypriotou, Gallic Beauchef et al. (jefferson.edu)
  • 1. A collagen composition comprising a polymerizable product formed by a reaction between (a) a partially fibrillar collagen derived by subjecting an acid solubilized collagen to a pH ranging from 7.0 to 7.6 and a temperature ranging from 25 C. to 37 C. for a time sufficient to initiate fibrillogenesis and (b) at least one of an acylating agent and sulfonating agent. (google.com.au)
  • To observe the effects and mechanisms of beta-endorphin (beta-END) preventing collagen induced arthritis (CIA) by neuroimmuno-regulating pathway. (nel.edu)
  • It may not be so surprising that collagen (derived from the Greek word for glue) and Aβ42 peptides-which are famously sticky-might bind to each other. (alzforum.org)
  • Here, the influence of the aza-amino acids α-azaproline, azaglycine, and -azaproline on the structure and stability of collagen is studied through incorporation into collagen model peptides (CMPs) and analyzed through a variety of computational methods including DFT and molecular dynamics calculations. (upenn.edu)
  • Exactly how and why the collagen and the peptides join is uncertain. (newswise.com)
  • He believes the peptides make themselves at home within gaps formed by loose collagen strands. (newswise.com)
  • When the peptides bind with collagen, these attached agents can dramatically change the way collagen behaves in the body. (newswise.com)
  • In their recent journal paper, Yu and his colleagues reported that they had attached a chemical, polyethylene glycol, to the peptides, causing collagen to repel cells instead of attracting them. (newswise.com)
  • Fibronectin (FN), bone sialoprotein-I (BSP-I), Type I collagen, and a number of synthetic peptides containing the integrin attachment sequence (RDG) were evaluated for their ability to affect stress tolerance in osteo-ligament cells (OL). (biomedsearch.com)
  • Both human and bovine collagen is widely used as dermal fillers for treatment of wrinkles and skin aging. (wikipedia.org)
  • To determine the validity of this concept in vivo, the effect of administering TNF-neutralizing antibodies to mice with collagen-induced arthritis has been studied. (pnas.org)
  • Although not thermodynamically favourable, the deposition of calcium phosphate based mineral within collagen fibres occurs in vivo in bone and dentine. (open.ac.uk)
  • Echocardiograms were performed weekly with a 15-MHz linear transducer, and at 4 weeks, collagen isoform determinations and in vivo hemodynamics were performed. (ahajournals.org)
  • On this basis, it would be predicted that TNFα blockade would result in reduced IL-17 expression, and to test this hypothesis in vivo, we investigated the dependence of IL-17 expression on TNFα in collagen-induced arthritis (CIA). (rupress.org)
  • Anti-TNF administered prior to disease onset significantly reduced paw swelling and histological severity of arthritis without reducing the incidence of arthritis or the level of circulating anti-type II collagen IgG. (pnas.org)
  • CIA was induced by Native bovine type II collagen emulsified with complete Freund's adjuvant (CFA). (nel.edu)
  • To investigate the effect of blockade of TNFα on the production of IL-17, DBA/1 mice were immunized with bovine type II collagen in CFA. (rupress.org)
  • As first author Jason Cheng and colleagues note, the role of various forms of collagen in peripheral organs is well established, but little is known about collagen in the brain. (alzforum.org)
  • Mutations in the COL6A1 , COL6A2 , and COL6A3 genes can cause the various forms of collagen VI-related myopathy. (medlineplus.gov)
  • UN-crosslinked and UV-crosslinked fish collagen membrane records a very high temperature of helix denaturation at 197℃ and 215℃, shrinkage temperature at 50℃ ± 3.2℃ and 62℃ ± 2.7℃ and tensile strength at 16.89 ± 2.5 and 120.02 ± 1.0 Kg/cm2 respectively. (scirp.org)
  • The results revealed that excessive grafting density of succinylated collagen would improve their hydrophilicity but weaken their self-assembly property, although the triple helix of collagen could be reserved after succinylation. (springer.com)
  • Dedicated prolyl hydroxylase, lysyl hydroxylase, and collagen glycosyltransferase enzymes localized in the endoplasmic reticulum mediate these modifications prior to the formation of the collagen triple helix. (uzh.ch)
  • Also, collagen IV lacks the regular glycine in every third residue necessary for the tight, collagen helix. (wikipedia.org)
  • Arshad, Rooshan, "Fabrication and Characterization of Collagen-Polypyrrole Constructs Using Direct-Ink Write Additive Manufacturing" (2019). (uwo.ca)
  • The SHG-CD can be observed with the microscope when: (i) the chiral second-order susceptibility tensor component has a non-zero value, (ii) a phase retardance is present between the chiral and achiral components of the second-order susceptibility tensor and (iii) the collagen fibres are tilted out of the image plane. (nature.com)
  • Both positive and negative areas of SHG-CD are observed in microscopy images, which relates to the anti-parallel arrangement of collagen fibres in different fascicles of the tendon. (nature.com)
  • For example, well-aligned collagen fibres provide the required viscoelastic properties of tendon and add elasticity to the composite material of bone. (nature.com)
  • Therefore, by extracting χ (2) values, the organisation of collagen fibres can be characterised and certain molecular details about the collagen structure can be inferred. (nature.com)
  • In this study, we utilize the M18 serotype S. pyogenes strain MGAS8232 to demonstrate that the presence of the FCT region is critical in binding collagen type IV and fibronectin, and is additionally required for invasion into human pharyngeal cells, despite not impacting adherence to these cells. (uwo.ca)
  • In this study we remove this region from the bacteria's genome and assess the adherence capabilities of this mutant to several components found at the site of infection, including collagen type IV, fibronectin, and human pharyngeal cells and demonstrated that the FCT region is required to bind collagen type IV and fibronectin, but not the pharyngeal cells. (uwo.ca)
  • Increased survival from heat was limited to cells spread on fibronectin, BSP-I, and Type I collagen. (biomedsearch.com)
  • These form the most abundant collagens in vertebrates. (news-medical.net)
  • This is the most abundant collagen of the human body. (news-medical.net)
  • Collagens, the most abundant proteins in animals, are modified by hydroxylation of proline and lysine residues and by glycosylation of hydroxylysine. (uzh.ch)
  • Despite several investigations, the transcriptional mechanisms that regulate the expression of both type I collagen genes (COL1A1 and COL1A2) in either physiological or pathological situations, such as scleroderma, are not completely known. (jefferson.edu)
  • Mutations in the COL6A1 , COL6A2 , and COL6A3 genes result in a decrease or lack of type VI collagen or the production of abnormal type VI collagen. (medlineplus.gov)
  • Mutations to the genes coding for collagen IV lead to Alport syndrome. (wikipedia.org)
  • To investigate the role of prolyl 3-hydroxylase 2 (P3H2) and function of 3-hydroxylation in type IV collagen, we created a KO mouse. (pnas.org)
  • Collagen-related diseases most commonly arise from genetic defects or nutritional deficiencies that affect the biosynthesis, assembly, postranslational modification, secretion, or other processes involved in normal collagen production. (news-medical.net)
  • Prolyl 4-hydroxylase (P4H) is an essential enzyme in collagen biosynthesis. (ahajournals.org)
  • In this study, we have investigated the role of β1 integrin and ILK in the activation of the AKT/mTOR pathway, and the role of AKT/mTOR in the subsequent expression and translation of collagen in human tendon cells. (nature.com)
  • We suggest, therefore, that water-generated tensile stresses may play a role in living collagen-based materials such as tendon or bone. (mit.edu)
  • Though that microarray analysis is still ongoing, "the one gene that really stood out from all the others was collagen VI," said Mucke, which prompted the researchers to publish that finding ahead of the total analysis. (alzforum.org)
  • The authors decided to focus on a Smad3 responsive element in the collagen gene, since Smad3 is activated by transforming growth factor β (TGFβ), a cytokine that is elevated in hAPP mouse brain and also in the AD brain (see ARF related news story ). (alzforum.org)
  • The product of COL4A5, the alpha 5(IV) collagen chain, is a specific component of GBM within the kidney, and the gene maps to the same X chromosomal region as does Alport syndrome. (sciencemag.org)
  • Unlike the incorporation of pre‐formed particles, the new process allows for both improved physical properties of collagen hydrogels and controlled drug delivery. (archives-ouvertes.fr)
  • Incorporation of Fibrin Into a Collagen-Glycosaminoglycan Matrix Resul" by Claire Brougham, Tanya J. Levingstone et al. (dit.ie)
  • Collagens constitute nearly 30% of all proteins in our body. (pnas.org)
  • Since collagen is a family of proteins, the glycation of two different collagen types was studied. (open.ac.uk)
  • The deduced amino acid sequence of the collagen type-I α1 chain was homologous to those of the proteins from other vertebrate species. (bioone.org)
  • Whereas collagen-like proteins have been described in some fungi, bacteria, and viruses, the post-translational machinery modifying collagens has never been described outside of animals. (uzh.ch)
  • Our proteomics data show that reductive stress results in the loss of a small subset of reductant-sensitive proteins (including the collagens COL1A1/2 and COL3A1, and the myopathy-associated collagens COL6A1/2/3), and the down-regulation of targets downstream of the MAPK pathway. (mcponline.org)
  • These effects were opposed by myCAF-expressed type I collagen, which suppressed tumor growth by mechanically restraining tumor spread, overriding its own stiffness-induced mechanosignals. (jci.org)
  • 1. Mechanically cutting and grinding a source of collagen into particulate form. (google.com)
  • In addition to the above mentioned disorders, excessive deposition of collagen occurs in scleroderma. (news-medical.net)
  • Increased glomerular and mesangial deposition of collagen IV occurs in diabetic nephropathy and increased urinary levels are associated with the extent of renal injury. (wikipedia.org)
  • Gradual calcium deposition within collagen occurs as a natural function of aging. (wikipedia.org)
  • BACKGROUND: This study was to investigate the effect of collagen grafted porous biphasic calcium phosphate (BCP) on cell attachment, proliferation, and differentiation. (mendeley.com)
  • Thus, fibripositor-mediated assembly of collagen has generally become the standard model to explain the initial production of highly anisotropic, load-bearing collagenous arrays. (royalsocietypublishing.org)
  • These results suggest that giant viruses may have contributed to the evolution of collagen biology. (uzh.ch)
  • To fully understand the mechanism of collagen alteration, in our study photo-disruptive effects were induced in collagen I matrix by point-irradiation with a femtosecond Ti-sapphire laser under controlled laser ablation settings. (rsc.org)
  • The specifics of how the nanoscale properties of collagen (e.g., the crosslinking profile) affect the mechanical integrity of bone at larger length scales is poorly understood despite growing evidence that collagen's nanoscale properties are altered with disease. (bioquant.com)
  • Liver fibrosis and cirrhosis are associated with the deposition of collagen IV in the liver. (wikipedia.org)
  • The Food Safety and Inspection Service (FSIS) is amending its meat inspection regulations to permit the use of pork collagen and transglutaminase enzyme (TG enzyme), in limited amounts, as binders in certain standardized meat food products. (federalregister.gov)
  • We demonstrate that the L230 open reading frame of the giant virus Acanthamoeba polyphaga mimivirus encodes an enzyme that has distinct lysyl hydroxylase and collagen glycosyltransferase domains. (uzh.ch)
  • Whereas in animals from sponges to humans the transfer of galactose to hydroxylysine in collagen is conserved, the mimivirus L230 enzyme transfers glucose to hydroxylysine, thereby defining a novel type of collagen glycosylation in nature. (uzh.ch)
  • The utilization of glucose instead of the galactose found throughout animals as well as a bifunctional enzyme rather than two separate enzymes may represent a parallel evolutionary track in collagen biology. (uzh.ch)
  • found that thrombospondin-1 (TSP1) bound to and inhibited the processing of the precursor form of the collagen cross-linking enzyme lysyl oxidase. (sciencemag.org)
  • Spatial distribution of calcium phosphate crystallinity and the collagen crosslinks near DEJ were studied using confocal Raman microscopy and calculated by different methods. (spiedigitallibrary.org)
  • Applications of our research include discovery of anti-fibrotic antibodies and elucidating their interactions with collagen, and using insights from our angiogenesis studies and collagen structure-function model to inform the design of super-angiogenic collagens and collagen mimetics. (jefferson.edu)
  • Remarkably, the chemical chaperone 4-phenylbutyric acid and small-molecule inhibitors of MAPK and 2-oxoglutarate-dependent collagen IV-modifying enzymes rescued ER retention of collagen IV and EC apoptosis and resulted in normal developmental angiogenesis. (jci.org)
  • EC-specific disruption of Rasa1 during developmental angiogenesis results in retention of collagen IV within BECs. (jci.org)
  • A randomized, double-blind, multicenter, controlled clinical trial of chicken type II collagen in patients with rheumatoid arthritis. (biomedsearch.com)
  • OBJECTIVE: To assess the efficacy and safety of chicken type II collagen (CCII) in rheumatoid arthritis (RA) compared with methotrexate (MTX). (biomedsearch.com)
  • Hyaluronic acid is an important compound for collagen in the skin. (medicalnewstoday.com)
  • Adding hyaluronic acid to the diet through food can easily help to boost collagen levels. (medicalnewstoday.com)
  • In this study, the synergistic effects of type I collagen (Col) and hyaluronic acid (HA) on the biological properties of Col/HA-multilayer-modified titanium coatings were investigated. (bioquant.com)
  • Collagen is used in bone grafting as it has a triple helical structure, making it a very strong molecule. (wikipedia.org)
  • Fish collagen matrix promoted NIH 3T3 and L6 cellular growth and proliferation. (scirp.org)
  • This article compares the properties of bacterial cellulose/fish collagen composites (BC/Col) after enzymatic and chemical cross-linking. (mdpi.com)
  • Prolyl 3-hydroxylation is a crucial posttranslational modification of collagens. (pnas.org)
  • They also found that Aβ failed to elevate collagen VI when administered to neurons from TGFβ receptor knockout mice. (alzforum.org)
  • Thus, 3-hydroxylation of type IV collagen is indispensable for embryonic development in mice. (pnas.org)
  • Compared to skin from wild-type mice, skin from Thbs1 −/− mice had reduced collagen cross-linking and reduced prolysyl oxidase (proLOX) abundance with increased conversion to catalytically active LOX. (sciencemag.org)
  • The aims of this study were to determine the therapeutic action of tolerogenic DCs in a type II collagen-induced arthritis model and to investigate their effects on Th17 cells and other T cell subsets in mice with established arthritis. (semanticscholar.org)
  • Th1 and Th17 cell populations were also expanded in collagen-immunized TNFR p55 −/− but not p75 −/− mice. (rupress.org)
  • Collagen can be used in collagen dressings, to attract new skin cells to wound sites. (medicalnewstoday.com)
  • Collagen helps the skin cells renew and repair themselves. (medicalnewstoday.com)
  • Moreover, hc-Krox DNA binding activity to its COL1A1-responsive element is increased in SF, cells producing higher amounts of type I collagen compared with ANF and FF. (jefferson.edu)
  • The current results strongly suggest that collagen type I is synthesized by theca cells and is localized in the same cell layer of the follicles. (bioone.org)
  • When the researchers added human cells to a lab dish, the cells migrated toward an untreated collagen film but avoided the modified collagen sample. (newswise.com)
  • A growth factor joined to collagen could encourage new cells to multiply. (newswise.com)
  • We evaluated early signal transduction events and effects on collagen formation in B 1 -stimulated human myofibroblast cells (IMR-90). (ahajournals.org)
  • In collagen-induced arthritis (CIA) of mouse, self-reactive T cells recognize a peptide antigen from type II collagen (CII). (jimmunol.org)
  • Therapeutic effect of tolerogenic dendritic cells in established collagen-induced arthritis is associated with a reduction in Th17 responses. (semanticscholar.org)
  • Human umbilical vein endothelial cells were cultured as a single layer on a collagen type-I coated permeable cell culture insert. (inserm.fr)
  • After culturing for five days, the insert was superimposed on collagen type-I gel containing cancer cells. (inserm.fr)
  • Persistent spreading of ligament cells on osteopontin/bone sialoprotein-I or collagen enhances tolerance to heat shock. (biomedsearch.com)
  • OL cells that persistently spread on BSP-I and Type I collagen had more survivors than cells demonstrating transient spreading on FN. (biomedsearch.com)
  • The present invention relates to a method for the preparation of biocompatible collagen-glycosaminoglycan composite materials by vapor phase crosslinking with aldehydes. (google.com)
  • In this study, we report the therapeutic effect of sST2-Fc in the murine model of collagen-induced arthritis. (jimmunol.org)