AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaHealth Care
CitalopramSerotonin Uptake InhibitorsAntidepressive Agents, Second-GenerationAntidepressive AgentsSerotonin Plasma Membrane Transport ProteinsDothiepinSerotoninFluoxetineParoxetineCyclohexanolsAntidepressive Agents, TricyclicClomipramineNorepinephrine Plasma Membrane Transport ProteinsSerotonin AntagonistsReceptor, Serotonin, 5-HT1AImipramineDepressive Disorder, MajorForensic PathologyHindlimb SuspensionTryptophan Hydroxylase8-Hydroxy-2-(di-n-propylamino)tetralinMianserinSertralineSerotonin Receptor Agonistsp-ChloroamphetamineFluvoxamineDepressive DisorderDrug OverdoseRaphe NucleiAdrenergic Uptake InhibitorsSerotonin 5-HT1 Receptor AntagonistsGastric LavageForensic ToxicologyNarcoticsNalorphineDrug and Narcotic ControlLevorphanolDrugs, GenericArrhythmias, CardiacUnited States Food and Drug AdministrationScopolamine HydrobromideEthylaminesVerbal BehaviorCognitionNeuropsychological TestsCognition DisordersTreatment OutcomeIntelligence
Citalopram
A furancarbonitrile that is one of the SEROTONIN UPTAKE INHIBITORS used as an antidepressant. The drug is also effective in reducing ethanol uptake in alcoholics and is used in depressed patients who also suffer from tardive dyskinesia in preference to tricyclic antidepressants, which aggravate this condition.
Serotonin Uptake Inhibitors
Compounds that specifically inhibit the reuptake of serotonin in the brain.
Antidepressive Agents, Second-Generation
A structurally and mechanistically diverse group of drugs that are not tricyclics or monoamine oxidase inhibitors. The most clinically important appear to act selectively on serotonergic systems, especially by inhibiting serotonin reuptake.
Antidepressive Agents
Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE INHIBITORS are useful as antidepressants apparently as a long-term consequence of their modulation of catecholamine levels. The tricyclic compounds useful as antidepressive agents (ANTIDEPRESSIVE AGENTS, TRICYCLIC) also appear to act through brain catecholamine systems. A third group (ANTIDEPRESSIVE AGENTS, SECOND-GENERATION) is a diverse group of drugs including some that act specifically on serotonergic systems.
Serotonin Plasma Membrane Transport Proteins
Sodium chloride-dependent neurotransmitter symporters located primarily on the PLASMA MEMBRANE of serotonergic neurons. They are different than SEROTONIN RECEPTORS, which signal cellular responses to SEROTONIN. They remove SEROTONIN from the EXTRACELLULAR SPACE by high affinity reuptake into PRESYNAPTIC TERMINALS. Regulates signal amplitude and duration at serotonergic synapses and is the site of action of the SEROTONIN UPTAKE INHIBITORS.
Dothiepin
A tricyclic antidepressant with some tranquilizing action.
Serotonin
A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.
Fluoxetine
The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.
Paroxetine
A serotonin uptake inhibitor that is effective in the treatment of depression.
Cyclohexanols
Monohydroxy derivatives of cyclohexanes that contain the general formula R-C6H11O. They have a camphorlike odor and are used in making soaps, insecticides, germicides, dry cleaning, and plasticizers.
Antidepressive Agents, Tricyclic
Substances that contain a fused three-ring moiety and are used in the treatment of depression. These drugs block the uptake of norepinephrine and serotonin into axon terminals and may block some subtypes of serotonin, adrenergic, and histamine receptors. However the mechanism of their antidepressant effects is not clear because the therapeutic effects usually take weeks to develop and may reflect compensatory changes in the central nervous system.
Clomipramine
A tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine.
Norepinephrine Plasma Membrane Transport Proteins
Sodium chloride-dependent neurotransmitter symporters located primarily on the PLASMA MEMBRANE of noradrenergic neurons. They remove NOREPINEPHRINE from the EXTRACELLULAR SPACE by high affinity reuptake into PRESYNAPTIC TERMINALS. It regulates signal amplitude and duration at noradrenergic synapses and is the target of ADRENERGIC UPTAKE INHIBITORS.
Serotonin Antagonists
Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or SEROTONIN RECEPTOR AGONISTS.
Receptor, Serotonin, 5-HT1A
A serotonin receptor subtype found distributed through the CENTRAL NERVOUS SYSTEM where they are involved in neuroendocrine regulation of ACTH secretion. The fact that this serotonin receptor subtype is particularly sensitive to SEROTONIN RECEPTOR AGONISTS such as BUSPIRONE suggests its role in the modulation of ANXIETY and DEPRESSION.
Imipramine
The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.
Depressive Disorder, Major
Marked depression appearing in the involution period and characterized by hallucinations, delusions, paranoia, and agitation.
Forensic Pathology
The application of pathology to questions of law.
Hindlimb Suspension
Technique for limiting use, activity, or movement by immobilizing or restraining animal by suspending from hindlimbs or tails. This immobilization is used to simulate some effects of reduced gravity and study weightlessness physiology.
Tryptophan Hydroxylase
An enzyme that catalyzes the hydroxylation of TRYPTOPHAN to 5-HYDROXYTRYPTOPHAN in the presence of NADPH and molecular oxygen. It is important in the biosynthesis of SEROTONIN.
8-Hydroxy-2-(di-n-propylamino)tetralin
A serotonin 1A-receptor agonist that is used experimentally to test the effects of serotonin.
Mianserin
A tetracyclic compound with antidepressant effects. It may cause drowsiness and hematological problems. Its mechanism of therapeutic action is not well understood, although it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors.
Sertraline
A selective serotonin uptake inhibitor that is used in the treatment of depression.
Serotonin Receptor Agonists
Endogenous compounds and drugs that bind to and activate SEROTONIN RECEPTORS. Many serotonin receptor agonists are used as ANTIDEPRESSANTS; ANXIOLYTICS; and in the treatment of MIGRAINE DISORDERS.
p-Chloroamphetamine
Chlorinated analog of AMPHETAMINE. Potent neurotoxin that causes release and eventually depletion of serotonin in the CNS. It is used as a research tool.
Fluvoxamine
A selective serotonin reuptake inhibitor that is used in the treatment of DEPRESSION and a variety of ANXIETY DISORDERS.
Depressive Disorder
An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood disturbance is prominent and relatively persistent.
Drug Overdose
Accidental or deliberate use of a medication or street drug in excess of normal dosage.
Raphe Nuclei
Collections of small neurons centrally scattered among many fibers from the level of the TROCHLEAR NUCLEUS in the midbrain to the hypoglossal area in the MEDULLA OBLONGATA.
Adrenergic Uptake Inhibitors
Drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants (ANTIDEPRESSIVE AGENTS, TRICYCLIC) and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin.
Serotonin 5-HT1 Receptor Antagonists
Drugs that bind to but do not activate SEROTONIN 5-HT1 RECEPTORS, thereby blocking the actions of SEROTONIN 5-HT1 RECEPTOR AGONISTS. Included under this heading are antagonists for one or more of the specific 5-HT1 receptor subtypes.
Gastric Lavage
Medical procedure involving the emptying of contents in the stomach through the use of a tube inserted through the nose or mouth. It is performed to remove poisons or relieve pressure due to intestinal blockages or during surgery.
Forensic Toxicology
The application of TOXICOLOGY knowledge to questions of law.
Narcotics
Agents that induce NARCOSIS. Narcotics include agents that cause somnolence or induced sleep (STUPOR); natural or synthetic derivatives of OPIUM or MORPHINE or any substance that has such effects. They are potent inducers of ANALGESIA and OPIOID-RELATED DISORDERS.
Nalorphine
A narcotic antagonist with some agonist properties. It is an antagonist at mu opioid receptors and an agonist at kappa opioid receptors. Given alone it produces a broad spectrum of unpleasant effects and it is considered to be clinically obsolete.
Drug and Narcotic Control
Control of drug and narcotic use by international agreement, or by institutional systems for handling prescribed drugs. This includes regulations concerned with the manufacturing, dispensing, approval (DRUG APPROVAL), and marketing of drugs.
Levorphanol
A narcotic analgesic that may be habit-forming. It is nearly as effective orally as by injection.
Drugs, Generic
Drugs whose drug name is not protected by a trademark. They may be manufactured by several companies.
Arrhythmias, Cardiac
Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.
United States Food and Drug Administration
An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.
Scopolamine Hydrobromide
An alkaloid from SOLANACEAE, especially DATURA and SCOPOLIA. Scopolamine and its quaternary derivatives act as antimuscarinics like ATROPINE, but may have more central nervous system effects. Among the many uses are as an anesthetic premedication, in URINARY INCONTINENCE, in MOTION SICKNESS, as an antispasmodic, and as a mydriatic and cycloplegic.
Ethylamines
Verbal Behavior
Includes both producing and responding to words, either written or spoken.
Cognition
Intellectual or mental process whereby an organism obtains knowledge.
Neuropsychological Tests
Tests designed to assess neurological function associated with certain behaviors. They are used in diagnosing brain dysfunction or damage and central nervous system disorders or injury.
Cognition Disorders
Disturbances in mental processes related to learning, thinking, reasoning, and judgment.
Treatment Outcome
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Intelligence
The ability to learn and to deal with new situations and to deal effectively with tasks involving abstractions.

Modulation of noradrenergic neuronal firing by selective serotonin reuptake blockers. (1/558)

Using in vivo extracellular unitary recording, the effect of short term (2-day) and long-term (21-day) administration of the selective 5-HT reuptake inhibitor (SSRI) paroxetine (10 mg kg(-1) day(-1), s.c. using osmotic minipumps) was examined on the spontaneous firing activity of locus coeruleus noradrenergic neurons. Long-term but not short-term treatment significantly decreased firing activity. Thus, it appears that enhancing 5-HT neurotransmission by sustained SSRI administration leads to a reduction of the firing rate of noradrenergic neurons. The SSRI paroxetine therefore alters the activity of noradrenergic neurons with a delay that is consistent with its therapeutic action in depression and panic disorder.  (+info)

Effect of activated charcoal alone or given after gastric lavage in reducing the absorption of diazepam, ibuprofen and citalopram. (2/558)

AIMS: The efficacy of activated charcoal alone, and gastric lavage followed by charcoal in reducing the absorption of diazepam, ibuprofen and citalopram was studied in healthy volunteers. METHODS: In a randomized cross-over study with three phases, nine healthy volunteers were administered single oral doses of 5 mg diazepam, 400 mg ibuprofen and 20 mg citalopram, taken simultaneously after an overnight fast. Thirty minutes later, the subjects were assigned to one of the following treatments: 200 ml water (control), 25 g activated charcoal as a suspension in 200 ml water or gastric lavage followed by 25 g charcoal in suspension given through the lavage tube. Plasma concentrations of diazepam, ibuprofen and citalopram were determined up to 10 h. RESULTS: The AUC(0,10 h) of diazepam was reduced by 27% (P<0.05) by both charcoal alone and charcoal combined with lavage. The increase in plasma diazepam concentration from 0.5 h onwards was prevented by both interventions (P+info)

Serotonin reuptake inhibition by citalopram in rat strains differing for their emotionality. (3/558)

Acute administration of the selective serotonin (5-HT) reuptake inhibitor (SSRI), citalopram (1-10 mg/kg, i.p. 1 h before an elevated plus-maze test), to Spontaneously Hypertensive rats (SHRs), Lewis (LEW) rats, and Wistar-Kyoto (WKY) rats, i.e., rat strains differing for their emotionality, promoted anxiety, and/or hypoactivity, except in WKY rats. In the three strains, such a pretreatment increased central 5-HT levels and/or decreased 5-hydroxyindoleacetic acid levels. Hippocampal, but not midbrain or striatal, [3H]citalopram binding at 5-HT transporters was lower in WKY rats than in SHRs. However, neither [3H]5-HT reuptake kinetics nor the potencies of citalopram (1-1000 nM) to inhibit [3H]5-HT reuptake into hippocampal and striatal synaptosomes differed between strains. This was confirmed in vivo by means of microdialysis in the hippocampus of freely moving rats. Thus, although LEW rats displayed a 3-4 fold higher baseline level of extracellular 5-HT in the hippocampus, compared with SHRs and WKY rats, local perfusion with 1 microM citalopram promoted relative increases in extracellular 5-HT levels over baseline that were similar in all strains. Lastly, acute i.p. administration of 3.3 mg/kg citalopram (1 h beforehand) decreased to similar extents [3H]5-HT reuptake into hippocampal synaptosomes from SHRs and WKY rats. This study indicates that genetic differences in the behavioural responses to SSRIs may involve 5-HT transporter-independent mechanisms.  (+info)

The activity of rat brain nitric oxide synthase following chronic antidepressant treatment. (4/558)

Nitric oxide synthase (NOS) is an enzyme involved in the activation of the glutamate/NMDA receptor-induced cascade of events. In this study we investigated the NOS activity in different rat brain regions after chronic electroconvulsive, imipramine and citalopram treatments. Chronic electroconvulsive treatment significantly increased the NOS activity (by 49%) in the cerebral cortex. However, chronic treatment with imipramine or citalopram did not alter the activity of NOS in all examined brain regions (cortex, hippocampus or cerebellum). The increased NOS activity after electroconvulsive but not pharmacologic (imipramine or citalopram) treatment may well reflect the differences between the adaptive changes of the NMDA receptor complex induced by these treatments.  (+info)

Citalopram controls phobic symptoms in patients with panic disorder: randomized controlled trial. (5/558)

OBJECTIVE: To examine the effects of long-term treatment with citalopram or clomipramine on subjective phobic symptoms in patients with panic disorder. DESIGN: Double-blind, parallel-group, five-arm study. PATIENTS: Patients aged 18 to 65 years with panic disorder (DMS-III-R diagnosis) and with no major depressive symptoms. INTERVENTIONS: Four hundred and seventy-five patients were randomized to 8 weeks of treatment with either citalopram (10 to 15 mg per day; 20 to 30 mg per day; or 40 to 60 mg per day), clomipramine (60 to 90 mg per day) or placebo. Two hundred and seventy-nine patients continued treatment after the 8-week acute phase. OUTCOME MEASURES: Phobic symptoms were assessed using the Phobia Scale and the Symptom Checklist's (SCL-90) phobia-related factors. RESULTS: At all dosages, citalopram was more efficacious than placebo, with 20 to 30 mg generally being the most effective dosage. Citalopram (20 to 30 mg) generally decreased phobic symptoms significantly more than placebo after Month 3. Interpersonal sensitivity decreased when measured on the respective SCL-90 sub-scale. Alleviation of phobic symptoms generally continued to increase towards the end of the treatment. The effect of clomipramine was not as consistent. CONCLUSIONS: All active treatment groups, especially the group receiving 20 to 30 mg per day of citalopram, effectively controlled phobic symptoms in patients with panic disorder. Long-term treatment with citalopram further decreased phobic symptoms.  (+info)

Acute psychological effects of 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") are attenuated by the serotonin uptake inhibitor citalopram. (6/558)

3,4-Methylenedioxymethamphetamine (MDMA, "Ecstasy") is a recreational drug that has been shown to release serotonin (5-HT) and dopamine (DA) in animals. The effect of MDMA on 5-HT release can be blocked by 5-HT uptake inhibitors such as citalopram, suggesting that MDMA interacts with the 5-HT uptake site. It is unknown whether this mechanism is also responsible for the psychological effects of MDMA in humans. We investigated the effect of citalopram pretreatment (40 mg iv) on the psychological effects of MDMA (1.5 mg/kg po) in a double-blind placebo-controlled psychometric study in 16 healthy human volunteers. MDMA produced an emotional state with heightened mood, increased self-confidence and extroversion, moderate derealization, and an intensification of sensory perception. Most of these effects were markedly reduced by citalopram. This finding suggests that the psychological effects of MDMA are mediated via action at the 5-HT uptake site to increase 5-HT release through the carrier, as expected from animal studies.  (+info)

Citalopram--a review of pharmacological and clinical effects. (7/558)

OBJECTIVE: To provide clinicians with a critical evaluation of citalopram, a selective serotonin reuptake inhibitor (SSRI) that has been available in Canada since March 1999. DATA SOURCES: Commercial searches (MEDLINE and BiblioTech) and an "in-house" search (InfoDrug) were used to find published English-language references for clinical and preclinical publications. There was no restriction of publication dates. Primary index terms used were: pharmacological properties, receptors, pharmacological selectivity, pharmacokinetics, age-related pharmacokinetics, sex-related pharmacokinetics, renal dysfunction, hepatic dysfunction, cytochrome activity, drug interactions, adverse reactions, antidepressant switching, precautions, overdose, drug discontinuation, children, geriatric, depression, combination therapy, placebo control, refractory depression, anxiety disorders and medical disorders. STUDY SELECTION: A total of 74 studies were reviewed. Twenty-one of these studies specifically examined the clinical efficacy and tolerability of citalopram in depressive disorders as well as other disorders. In depressive disorders, clinical studies were required to have either placebo or active comparison controls for a minimum of 3 weeks. For other disorders, in the absence of double-blind trials, open-label studies were included. Pharmacological studies were limited to animal studies focusing on citalopram's selectivity and receptor specificity, and positron emission tomography studies were incorporated to include human pharmacological data. Pharmacokinetic studies focused on the metabolism, safety and tolerability of citalopram, specifically with reference to adverse reactions, drug interactions and overdose in addition to citalopram's effect on vulnerable populations, such as children, the elderly and patients with metabolic diseases. DATA EXTRACTION: Data on clinical studies were summarized according to test measures, study duration and outcome of study. Pharmacokinetic and pharmacodynamic studies were summarized according to properties and interactions. Adverse reactions were extracted to outline citalopram's safety profile. DATA SYNTHESIS: Citalopram is an SSRI antidepressant with a more specific and selective pharmacological profile than other antidepressants of its class. It is well tolerated, and drug interactions are not a significant concern. It is also reasonably safe for populations vulnerable to pharmacokinetic effects, such as the elderly and patients with metabolic diseases. In addition to its tolerability, citalopram is effective in the treatment of major depression, other depressive disorders and panic disorder. It has the potential to effectively treat other anxiety disorders and substance-use disorders; in addition, it may be useful in several medical conditions. CONCLUSIONS: There is evidence to support the role of citalopram as a well-tolerated and effective SSRI antidepressant. There is a need for further evaluation of its role in psychiatric disorders other than major depressive disorder.  (+info)

Variations in response to citalopram in men and women with alcohol dependence. (8/558)

OBJECTIVE: To examine the differential effects of citalopram on alcohol consumption in nondepressed women and men with mild to moderate alcohol dependence. DESIGN: Prospective, placebo-controlled study. PARTICIPANTS: Sixty-one subjects (34 men and 27 women). INTERVENTIONS: After a 2-week baseline, subjects were randomly assigned to 12 weeks of citalopram (40 mg per day) (n = 15 women, 16 men) or placebo (n = 12 women, 18 men). All received brief standard psychosocial interventions. OUTCOME MEASURES: Alcohol Dependence Scale, Montgomery-Asberg Depression Scale, Michigan Alcohol Screening Test, State-Trait Anxiety Inventory and daily alcohol intake. RESULTS: Pretreatment sex differences were evident in alcohol consumption, alcohol dependence, alcohol-related problems and on anxiety and depression measures. After treatment, analyses of covariance with depression and anxiety scores as covariates revealed a differential benefit of citalopram for men. Men receiving citalopram reduced average drinks per day by 44%, whereas women exhibited a 27% decrease (p < 0.05). CONCLUSIONS: Men may benefit more than women from citalopram in the treatment of alcohol dependence. These findings highlight the importance of examining sex as a significant variable in evaluating response to pharmacotherapy.  (+info)

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The role of the selective serotonin reuptake inhibitor citalopram in irritable bowel syndrome | GutThe role of the selective serotonin reuptake inhibitor citalopram in irritable bowel syndrome | Gut
We read with great interest the article by Tack et al on the effect of the selective serotonin reuptake inhibitor (SSRI) citalopram on symptoms in patients with irritable bowel syndrome (IBS) (Gut 2006;55:1095-103). The usefulness of the results of this study are however debatable. Several previous studies have investigated the effect of tricyclic antidepressants and SSRIs on functional gastrointestinal symptoms. Because of errors or lack of clarity in study design, inclusion of very selected patient populations and, above all, small sample sizes, their role in the treatment of patients with IBS in daily clinical practice remains unclear.. The study of Tack et al, as already correctly pointed out by Creed in his commentary (Gut 2006;55:1065-7), also suffers from major shortcomings in study design, poor description of study population and no information on whether or not subjects and physicians/investigators were blinded and, if yes, how ...
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The researchers also measured depression and anxiety scores.. The effect of acute administration of citalopram on colonic sensitivity and on colonic response to feeding was assessed as a predictor of response to the drug.. The research team found after 3 and 6 weeks of treatment that citalopram improved abdominal pain, and bloating.. Impact of symptoms on daily life, and overall well being compared was also improved after 3 and 6 weeks with citalopram.. There was only a modest effect on stool pattern.. Changes in depression or anxiety scores were not related to symptom improvement.. The team noted that the effect of acute administration of citalopram during a colonic barostat study did not predict clinical outcome.. The researchers confirmed the benefit of citalopram over placebo after the analysis of the first treatment period as a double blind parallel arm study.. Dr Tacks team concluded, The selective serotonin reuptake inhibitors citalopram significantly improves irritable bowel syndrome ...
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Script error: No such module TemplatePar.Expression error: Unexpected , operator. Desmethylcitalopram is an active metabolite of the antidepressant drugs citalopram (racemic) and escitalopram (the S-enantiomer, which would be called desmethylescitalopram). Like citalopram and escitalopram, desmethylcitalopram functions as a selective serotonin reuptake inhibitor (SSRI), and is responsible for some of its parents therapeutic benefits. ...
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Serotonin has been suggested to be important in human development, especially cardiac and craniofacial developments [18,19,20]. Despite the safety concerns about the effects of SSRIs on human development in utero, in general, these drugs are preferred over tricyclic antidepressants for the treatment of depression during pregnancy because they are known to be safer and have fewer adverse effects. Among SSRIs, citalopram is especially known to have few interactions in concomitant use with other drugs and is selects for 5-hydroxytryptamine uptake inhibition [21,22]. The trough plasma concentration of citalopram is even lower in pregnant women compared to non-pregnant women. This is likely a result from volume expansion and distribution and reduced plasma protein binding during pregnancy [23]. The lower plasma concentration of citalopram during pregnancy and its selectivity imply a theoretically lower teratogenicity of this drug; however, some controversy about the association of citalopram with ...
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Serotonin signaling suppresses generation of amyloid-β (Aβ) in vitro and in animal models of Alzheimers disease (AD). We show that in an aged transgenic AD mouse model (APP/PS1 plaque-bearing mice), the antidepressant citalopram, a selective serotonin reuptake inhibitor, decreased Aβ in brain interstitial fluid in a dose-dependent manner. Growth of individual amyloid plaques was assessed in plaque-bearing mice that were chronically administered citalopram. Citalopram arrested the growth of preexisting plaques and reduced the appearance of new plaques by 78%. In healthy human volunteers, citaloprams effects on Aβ production and Aβ concentrations in cerebrospinal fluid (CSF) were measured prospectively using stable isotope labeling kinetics, with CSF sampling during acute dosing of citalopram. Aβ production in CSF was slowed by 37% in the citalopram group compared to placebo. This change was associated with a 38% decrease in total CSF Aβ concentrations in the drug-treated group. The ...
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Escitalopram, like other SSRIs, has been shown to affect sexual functions causing side effects such as decreased libido, delayed ejaculation, genital anesthesia,[17] and anorgasmia.[18][19]. An analysis conducted by the FDA found a statistically insignificant 1.5 to 2.4-fold (depending on the statistical technique used) increase of suicidality among the adults treated with escitalopram for psychiatric indications.[20][21][22] The authors of a related study note the general problem with statistical approaches: due to the rarity of suicidal events in clinical trials, it is hard to draw firm conclusions with a sample smaller than two million patients.[23]. Escitalopram is not associated with significant weight gain. For example, 0.6 kg mean weight change after 6 months of treatment with escitalopram for depression was insignificant and similar to that with placebo (0.2 kg).[24] 1.4-1.8 kg mean weight gain was reported in 8-month trials of escitalopram for depression,[25] and generalized anxiety ...
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The Safety and Efficacy of Escitalopram in Pediatric Patients With Major Depressive Disorder - Full Text View - ClinicalTrials...The Safety and Efficacy of Escitalopram in Pediatric Patients With Major Depressive Disorder - Full Text View - ClinicalTrials...
Depression affects approximately 2.5% of children and 8% of adolescents. Escitalopram is the S-enantiomer of citalopram. Both escitalopram and citalopram are selective serotonin reuptake inhibitors (SSRIs) and are used to treat depression in adults. This study is designed to provide a systematic evaluation of the safety and efficacy of escitalopram in the treatment of depressed pediatric patients, 12 to 17 years of age. Patients completing the study will be eligible to enter an open-label extension study ...
https://clinicaltrials.gov/ct2/show/NCT00107120
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NG Citalopram: Citalopram belongs to a group of medications called selective serotonin reuptake inhibitors (SSRIs). It is used to treat depression. SSRIs improve depression by increasing the amount of serotonin (a neurotransmitter) in certain areas of the brain, which in turn improves the ability of the brain to transmit messages from one nerve cell to another.
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What is citalopram used for? | Reference.comWhat is citalopram used for? | Reference.com
Citalopram is a selective serotonin reuptake inhibitor, or SSRI, that is commonly prescribed for the treatment of depression, according to WebMD. Citalopram is the generic version of Celexa and is...
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中国科学院高能物理研究所机构知识库(IHEP OpenIR): Adolescent escitalopram administration modifies neurochemical alterations in the hippocampus of...中国科学院高能物理研究所机构知识库(IHEP OpenIR): Adolescent escitalopram administration modifies neurochemical alterations in the hippocampus of...
Early life stress is a potential precursor of eventual neuropsychiatric diseases and may result in altered neurodevelopment and function of the hippocampus, which thus provides a site at which potential interventions to modify the effects of early life stress may act. In this study, Sprague Dawley rat pups comprising male and female animals underwent maternal separation (MS) for 180 min from postnatal days (PND) 2 to 14, or were left with their dams. They subsequently received daily administration of saline (0.9%), escitalopram (10 mg/kg), or no treatment during adolescence (PND 43-60). All adult animals underwent brain magnetic resonance imaging (MRI) and bilateral hippocampal proton magnetic resonance spectroscopy ((1)H-MRS). Neither MS nor escitalopram treatment had a significant effect on hippocampal volume. Adult rats that experienced MS displayed significantly increased choline-containing compounds (Cho) and decreased N-acetylaspartate (NAA), glutamate (Glu) and Myo-inositol (MI) relative ...
http://ir.ihep.ac.cn/handle/311005/238658
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Bupropion or Buspirone May Augment Citalopram ResponseBupropion or Buspirone May Augment Citalopram Response
Sustained-Release Bupropion or Buspirone May Augment Citalopram Response March 23, 2006 by Laurie Barclay, MD, Medscape Patients with depression not responding adequately to citalopram may respond to the addition of either bupropion or buspirone, with the former having certain advantages, according to the results of a randomized study reported in the March 23 issue of The New England Journal of Medicine. Although clinicians frequently add a second medication to an initial, ineffective
https://forum.psychlinks.ca/showthread.php?3836-Bupropion-or-Buspirone-May-Augment-Citalopram-Response
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Anxiety Disease II: Efficacy and safety of sertraline, citalopram and venlafaxine in the treatment of Generalized Anxiety -...Anxiety Disease II: Efficacy and safety of sertraline, citalopram and venlafaxine in the treatment of Generalized Anxiety -...
Technologies: Venlafaxine, citalopram and sertraline. Indication: Treatment of generalized anxiety disorder. Technology characterization: Citalopram and sertraline belong to the class of Selective Serotonin Reuptake Inhibitors (SSRIs) and venlafaxine belongs to the class of Serotonin Reuptake Inhibitors and norepinephrine (SNRI).. Question: Venlafaxine, citalopram and sertraline are more effective and safe in the treatment of patients with generalized anxiety disorder than the technologies available in SUS?. Search and analysis of scientific evidence: the foundations The Cochrane Library (via BIREME), Medline (via Pubmed), Lilacs, APA PsycNET (via PsychINFO) and Centre for Reviews and Dissemination (CRD) were surveyed. We searched for systematic reviews (SR) of clinical trials that compared the drugs with each other and with other therapeutic options available in the Health System for the treatment of anxiety disorders. Reviews of health technologies (ATS) in international agencies and the ...
http://www.ccates.org.br/en/anxiety-disease-ii-efficacy-and-safety-of-sertraline-citalopram-and-venlafaxine-in-the-treatment-of-generalized-anxiety-2/
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J Clin Psychiatry/Mirtazapine Versus Selective Serotonin Reuptake InhibitorsJ Clin Psychiatry/Mirtazapine Versus Selective Serotonin Reuptake Inhibitors
The results of 3 completed comparative studies of mirtazapine versus selective serotonin reuptake inhibitors (SSRIs; fluoxetine, paroxetine, and citalopram) are reviewed. The studies aimed to compare efficacy and tolerability in acute treatment of inpatients and outpatients with major depressive disorder. In comparative trials with fluoxetine, patients who had high baseline total 17-item Hamilton Rating Scale for Depression (HAM-D) and depressed mood item scores were included (scores ≥ 21 and ≥ 2, respectively). In the comparative trials with citalopram and paroxetine, the inclusion criteria were total Montgomery-Asberg Depression Rating Scale (MADRS) score ≥ 22 and 17-item HAM-D score ≥ 18. In all 3 studies, statistically significant and clinically relevant differences in favor of mirtazapine were evident on several outcome variables. Against citalopram and paroxetine, the differences in antidepressant efficacy were registered early in treatment but not later, thus suggesting ...
http://www.psychiatrist.com/JCP/article/Pages/1999/v60s17/v60s1704.aspx
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Women prescribed selective serotonin reuptake inhibitors (SSRI) , a co - Health Resources and Service Administration Pharmacy...Women prescribed selective serotonin reuptake inhibitors (SSRI) , a co - Health Resources and Service Administration Pharmacy...
Women prescribed selective serotonin reuptake inhibitors (SSRI) , a common class of antidepressants also used to ease menopausal symptoms such as hot flashes and night sweats, may face a long-term rise in their risk for bone fracture, a new study suggests. #SSRI #Menopause #HotFlashes #NightSweats #fluoxetine #sertraline #paroxetine #Celexa #Paxil #Prozac #Zoloft #citalopram #escitalopram #fluvoxamine #Luvox. ...
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Genotype-Dependent Activity of Tryptophan Hydroxylase-2 Determines the Response to Citalopram in a Mouse Model of Depression |...Genotype-Dependent Activity of Tryptophan Hydroxylase-2 Determines the Response to Citalopram in a Mouse Model of Depression |...
This is supported by several findings. First, unresponsive strains (DBA/2J and BALB/c) are homozygous for the 1473G allele of TPH-2, whereas responsive strains (C57BL/6J and 129/Sv) are homozygous for the 1473C allele. This polymorphism, first reported by Zhang et al. (2004), was confirmed by the present study.. Second, in keeping with previous findings (Zhang et al., 2004), 5-HTP accumulation in the whole brain and striatum and 5-HT levels in the brain of DBA/2J and BALB/c mice were significantly lower than in the C57BL/6J and 129/Sv strains. Furthermore, citalopram inhibited brain 5-HT synthesis in C57BL/6J and 129/Sv mice but had significantly less effect in DBA/2J and BALB/c mice and no real effect in the striatum of DBA/2J mice. The fact that strain and citalopram had no effect on the accumulation of DOPA, the precursor of catecholamines, indicates the specificity of strain differences in 5-HTP accumulation and confirms that catecholamines are not involved in the antidepressant-like effect ...
http://www.jneurosci.org/content/25/36/8165.full
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Objective. Selective serotonin reuptake inhibitors (SSRIs), in addition to their antidepressant effects, have been reported to have antiinflammatory effects. The aim of this study was to assess the antiarthritic potential of 2 SSRIs, fluoxetine and citalopram, in murine collagen-induced arthritis (CIA) and in a human ex vivo disease model of rheumatoid arthritis (RA).. Methods. Following therapeutic administration of SSRIs, paw swelling was assessed and clinical scores were determined daily in DBA/1 mice with CIA. Joint architecture was examined histologically at the end of the treatment period. Cultures of human RA synovial membranes were treated with SSRIs, and cytokine production was measured. Toll-like receptor (TLR) function was examined in murine and human macrophages, human B cells, and human fibroblast-like synovial cells treated with SSRIs.. Results. Both SSRIs significantly inhibited disease progression in mice with CIA, with fluoxetine showing the greatest degree of efficacy at the ...
http://sro.sussex.ac.uk/7070/
Selective Serotonin Reuptake Inhibitors (SSRI) | PsychVisitSelective Serotonin Reuptake Inhibitors (SSRI) | PsychVisit
Selective Serotonin Reuptake Inhibitors (SSRI) The SSRIs are a group of antidepressants that all work by inhibiting the actions of serotonin transporters in the brain. These transporters normally remove serotonin that is circulating in the brain, and so blocking the actions of these transporters serves to increase the levels of circulating serotonin and the overall actions of serotonin on the brain
http://www.psychvisit.com/treatments/medication-class/SSRI.html
Use of selective serotonin reuptake inhibitors and risk of re-operation due to post-surgical bleeding in breast cancer patients...Use of selective serotonin reuptake inhibitors and risk of re-operation due to post-surgical bleeding in breast cancer patients...
Selective serotonin reuptake inhibitors (SSRI) decrease platelet-function, which suggests that SSRI use may increase the risk of post-surgical bleeding. Few studies have investigated this potential association. We conducted a population-based study of the risk of re-operation due to post-surgical bleeding within two weeks of primary surgery among Danish women with primary breast cancer. Patients were categorised according to their use of SSRI: never users, current users (SSRI prescription within 30 days of initial breast cancer surgery), and former users (SSRI prescription more than 30 days before initial breast cancer surgery). We calculated the risk of re-operation due to post-surgical bleeding within 14 days of initial surgery, and the relative risk (RR) of re-operation comparing SSRI users with never users of SSRI adjusting for potential confounders. 389 of 14,464 women (2.7%) were re-operated. 1592 (11%) had a history of SSRI use. Risk of re-operation was 2.6% among never users, 7.0% among current
https://bmcsurg.biomedcentral.com/articles/10.1186/1471-2482-10-3/peer-review
Selective Serotonin Reuptake Inhibitors (SSRI) and Their Impact on Growth Rates - DrGreene.comSelective Serotonin Reuptake Inhibitors (SSRI) and Their Impact on Growth Rates - DrGreene.com
Some of the most widely prescribed medicines in the world are selective serotonin reuptake inhibitors (SSRI). They are antidepressant medicines that have a
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Effects of agomelatine on sleep electroencephalogram parameters compared to selective serotonin reuptake inhibitors in patients...Effects of agomelatine on sleep electroencephalogram parameters compared to selective serotonin reuptake inhibitors in patients...
Effects of agomelatine on sleep electroencephalogram parameters compared to selective serotonin reuptake inhibitors in patients with major depressive disorder: a six-week randomised, double-blind parallel group study versus comparator, followed by a double-blind optional treatment extension period up to six months ...
http://adisinsight.springer.com/trials/700024967
Use of selective serotonin reuptake inhibitors and risk of re-operation due to post-surgical bleeding in breast cancer patients...Use of selective serotonin reuptake inhibitors and risk of re-operation due to post-surgical bleeding in breast cancer patients...
Selective serotonin reuptake inhibitors (SSRI) decrease platelet-function, which suggests that SSRI use may increase the risk of post-surgical bleeding. Few studies have investigated this potential association ...
https://research.regionh.dk/da/publications/use-of-selective-serotonin-reuptake-inhibitors-and-risk-of-reoperation-due-to-postsurgical-bleeding-in-breast-cancer-patients-a-danish-populationbased-cohort-study
J Clin Psychiatry/A Randomized Controlled Trial of Antidepressant Continuation for Major Depression Following Traumatic Brain...J Clin Psychiatry/A Randomized Controlled Trial of Antidepressant Continuation for Major Depression Following Traumatic Brain...
Objective: This study examines whether continuation therapy with citalopram can prevent a relapse following remission of major depression due to traumatic brain injury.. Method: After 65 subjects with DSM-IV-diagnosed major depression following traumatic brain injury were treated with open-label citalopram (20 mg to 50 mg/d), 25 subjects (38.5%) met criteria for remission. Of those, 21 (84.0%) were randomly assigned to either same-dose citalopram or placebo and followed monthly over 40 weeks. Remission was defined as a Hamilton Depression Rating Scale (HDRS) score of ≤ 7 or a Clinical Global Impressions-Improvement rating of much improved or better. The main outcome variable was the presence of relapse, as defined by meeting criteria for major depressive episode according to the DSM-IV and an HDRS score ≥ 16. Data were collected from February 16, 2005, to May 5, 2008.. Results: Ten subjects were randomly assigned to citalopram and 11 to placebo. There were 3 dropouts, including 1 for ...
http://www.psychiatrist.com/JCP/article/Pages/2010/v71n09/v71n0903.aspx
Some SSRI Antidepressants Associated With Serious Heart Arrhythmia Risk - RedorbitSome SSRI Antidepressants Associated With Serious Heart Arrhythmia Risk - Redorbit
Lawrence LeBlond for redOrbit.com - Your Universe Online. Some antidepressants, known as selective serotonin reuptake inhibitors (SSRIs), have been found to pose a small but serious risk on users´ hearts, according to new research. These drugs, which include citalopram and escitalopram, have been found to trigger a disturbance in QT interval (the duration of electrical activity of the heart muscle) heart rhythms.. The research, published today in the British Medical Journal, supports recent warnings by the US Food and Drug Administration (FDA) about how some SSRIs, including citalopram, may have similar effects.. Both UK and US regulators have already warned doctors to be extra careful when prescribing these drugs to certain patients, and also warned that maximum dosages should be lowered.. QT interval is measured with an ECG and varies with heart rate; it gets longer when the heart beats slower and shorter when the heart is beating faster. In the average man, the normal QT interval is less ...
http://www.redorbit.com/news/health/1112773843/heart-arrhythmia-risk-ssri-antidepressants-013013/
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CO Escitalopram - Uses, Side Effects, Interactions - MedBroadcast.comCO Escitalopram - Uses, Side Effects, Interactions - MedBroadcast.com
CO Escitalopram: Escitalopram belongs to the group of medications called selective serotonin reuptake inhibitors (SSRIs). It is used to treat depression, obsessive-compulsive disorder (OCD), and generalized anxiety disorder (GAD). It works by increasing levels of a neurotransmitter called serotonin in the brain. Increased serotonin levels can lead to an improved mood.
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Escitalopram by Sivem: Escitalopram belongs to the group of medications called selective serotonin reuptake inhibitors (SSRIs). It is used to treat depression, obsessive-compulsive disorder (OCD), and generalized anxiety disorder (GAD). It works by increasing levels of a neurotransmitter called serotonin in the brain. Increased serotonin levels can lead to an improved mood.
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Prophylactic citalopram reduced recurrences of unipolar major depression | Annals of Internal Medicine | American College of...Prophylactic citalopram reduced recurrences of unipolar major depression | Annals of Internal Medicine | American College of...
121 outpatients ≥ 65 years of age (mean age 75 y, 77% women) with unipolar major depression (Diagnostic and Statistical Manual of Mental Disorders, 4th edition [DSM-IV], 296.2x or 296.3x and Montgomery Åsberg Depression Rating Scale [MADRS] score ≥ 22) who responded to acute and continuation treatment with citalopram (20 to 40 mg) for 8 and 16 weeks, respectively. Response to both phases of treatment was defined by a MADRS score ≤ 11. Exclusion criteria included an index episode that lasted , 12 months; a history of schizophrenia, mania, hypomania, epilepsy, or drug or alcohol misuse; and a score of ≥ 5 on MADRS item 10 (suicidality). Follow-up was 100 ...
http://annals.org/aim/article-abstract/2539553/prophylactic-citalopram-reduced-recurrences-unipolar-major-depression
Molecular determinants for selective recognition of antidepressants in the human serotonin and norepinephrine transporters -...Molecular determinants for selective recognition of antidepressants in the human serotonin and norepinephrine transporters -...
Inhibitors of the serotonin transporter (SERT) and norepinephrine transporter (NET) are widely used in the treatment of major depressive disorder. Although SERT/NET selectivity is a key determinant for the therapeutic properties of these drugs, the molecular determinants defining SERT/NET selectivity are poorly understood. In this study, the structural basis for selectivity of the SERT selective inhibitor citalopram and the structurally closely related NET selective inhibitor talopram is delineated. A systematic structure-activity relationship study allowed identification of the substituents that control activity and selectivity toward SERT and NET and revealed a common pattern showing that SERT and NET have opposite preference for the stereochemical configuration of these inhibitors. Mutational analysis of nonconserved SERT/NET residues within the central substrate binding site was performed to determine the molecular basis for inhibitor selectivity. Changing only five residues in NET to the ...
https://nexs.ku.dk/forskning/molekylaer-fysiologi/publikationer/publikationer/?pure=da%2Fpublications%2Fmolecular-determinants-for-selective-recognition-of-antidepressants-in-the-human-serotonin-and-norepinephrine-transporters
Neurological function adversely affected by maternal SSRIs | Dangerous Drugs & Medical DevicesNeurological function adversely affected by maternal SSRIs | Dangerous Drugs & Medical Devices
In May, 2013, N.K. de Vries published an article titled Early neurological outcome of young infants exposed to selective serotonin reuptake inhibitors during pregnancy: results from the observational SMOK study. in the medical journal PLoS One. This Dutch research team explored poor neonatal outcomes linked to selective serotonin reuptake inhibitor drugs (SSRIs).. de Vries et al. write Use of selective serotonin reuptake inhibitors (SSRI) during pregnancy is common while the effect on the infants neurological outcome is unknown. Our objective was to determine the effects of prenatal SSRI-exposure on the infants neurological functioning, adjusted for maternal mental health.. Studying 63 SSRI-exposed infants (SSRI group) and 44 non-exposed infants (non-SSRI group), the team states that main outcome measures during the first week after birth and at three to four months were the quality of the infants general movements (GMs) according to Prechtl and a detailed motor optimality ...
https://www.dangerousdrugs.us/2014/08/neurological-function-adversely-affected-by-maternal-ssris.html
Citalopram and liver illness - Answers on HealthTapCitalopram and liver illness - Answers on HealthTap
Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Brenner on citalopram and liver illness: While elevations in liver enzymes can occur, development of fatty liver changes as a direct result of fluoxetine/olanzapine is unlikely. However increased caloric intake/weight gain and Insulin resistance can lead to fatty liver and Olanzapine has been linked to these events.
https://www.healthtap.com/topics/citalopram-and-liver-illness
Abdomen pain, dizzy, blood in stools, suspecting ectopic pregnancy, taken citalopram, had cyst in ovary before - Doctors...Abdomen pain, dizzy, blood in stools, suspecting ectopic pregnancy, taken citalopram, had cyst in ovary before - Doctors...
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MacropsiaMacropsia
Citalopram-induced macropsia is similar to zolpidem-induced macropsia since both types have been observed in relatively few ... Citalopram is an antidepressant that inhibits serotonin reuptake. The first case of macropsia thought to be induced by ... Ghanizadeh, A. Citalopram-induced macropsia. Clin Neuropharamcol 2007; 30(4): 246-247. Unnithan SB, Cutting JC. The cocaine ... Citalopram. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in depressive illness. ...
https://en.wikipedia.org/wiki/Macropsia
Brazilian Controlled Drugs and Substances ActBrazilian Controlled Drugs and Substances Act
CITALOPRAM 26. CLOMACRANE 27. CLOMETIAZOLE 28. CLOMIPRAMINE 29. CLOREXADOL 30. CLORPROMAZINE 31. CHLOROPROXENE 32. CLOTIAPINE ...
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CYP2D6CYP2D6
"Citalopram Oral Solution". Drugs.com. Nevels RM, Weiss NH, Killebrew AE, Gontkovsky ST (July 2013). "Methylphenidate and Its ...
https://en.wikipedia.org/wiki/CYP2D6
List of drugs: T-TdList of drugs: T-Td
Redirects to citalopram. talopram (INN) talosalate (INN) talotrexin ammonium (USAN) taloximine (INN) talsaclidine (INN) ...
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Schedule HSchedule H
CITALOPRAM HYDROBROMIDE 116. CLARITHROMYCIN 117. CLAVULANIC ACID 118. CLIDINIUM BROMIDE 119. CLINDAMYCIN ...
https://en.wikipedia.org/wiki/Schedule_H
EnantiomerEnantiomer
Citalopram is a racemate [1:1 mixture of (S)-citalopram and (R)-citalopram]; escitalopram [(S)-citalopram] is a pure enantiomer ... Enantiomers of citalopram. The top is (R)-citalopram and the bottom is (S)-citalopram. ... Another example is the antidepressant drugs escitalopram and citalopram. ... The dosages for escitalopram are typically 1/2 of those for citalopram. ...
https://en.wikipedia.org/wiki/Enantiomer
Selective serotonin reuptake inhibitorSelective serotonin reuptake inhibitor
"FDA Drug Safety". Citalopram and escitalopram: QT interval prolongation-new maximum daily dose restrictions (including in ... The SSRIs, in decreasing toxicity in overdose, can be listed as follows: > citalopram (due to the potential for QT interval ... The recommended maximum daily dose of citalopram and escitalopram was reduced due to concerns with QT interval prolongation. In ... Oström M, Eriksson A, Thorson J, Spigset O (1996). "Fatal overdose with citalopram". Lancet. 348 (9023): 339-40. doi:10.1016/ ...
https://en.wikipedia.org/wiki/Selective_serotonin_reuptake_inhibitor
Standard for the Uniform Scheduling of Medicines and PoisonsStandard for the Uniform Scheduling of Medicines and Poisons
Citalopram), SNRIs (e.g. Duloxetine, Milnacipran), TCAs (e.g. Imipramine and MAOIs (e.g. Selegiline, Moclobemide). ...
https://en.wikipedia.org/wiki/Standard_for_the_Uniform_Scheduling_of_Medicines_and_Poisons
ImpulsivityImpulsivity
Koran, Lorrin M.; Bullock, Kim D.; Hartston, Heidi J.; Elliott, Michael A.; d'Andrea, Vincent (2002). "Citalopram Treatment of ... Pharmacological interventions include the use of SSRIs, such as fluvoxamine, citalopram, escitalopram, and naltrexone Impulse ...
https://en.wikipedia.org/wiki/Impulsivity
Pseudobulbar affectPseudobulbar affect
Andersen, G; Vestergaard, K; Riis, J. O. (1993). "Citalopram for post-stroke pathological crying". The Lancet. 342 (8875): 837- ... Traditionally, antidepressants such as sertraline, fluoxetine,citalopram, nortriptyline and amitriptyline have been prescribed ...
https://en.wikipedia.org/wiki/Pseudobulbar_affect
Death of Conrad RoyDeath of Conrad Roy
In the United States, citalopram carries a boxed warning stating it may increase suicidal thinking and behavior in those under ... "Celexa (citalopram hydrobromide) Tablets/Oral Solution" (pdf). Prescribing Information. Forest Laboratories, Inc. Press, The ...
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Antidepresívum - WikipédiaAntidepresívum - Wikipédia
citalopram. SSRI. Citalec®, Citalopram-Vitabalans®, Citalopram-Mylan®, Zyloram®, Citalopram-Teva®, Citalopram-Zentiva® a i.. ...
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EscitalopramEscitalopram
Citalopram and escitalopram are associated with dose-dependent QT interval prolongation and should not be used in those with ... citalopram and venlafaxine in the treatment of major depression in Spain: clinical and economic consequences". Curr Med Res ... Whether escitalopram is more effective than citalopram or merely an effort to extend a patent over a product in which it was ... The most recent of these have concluded (with caveats in some cases) that escitalopram is modestly superior to citalopram in ...
https://en.wikipedia.org/wiki/Escitalopram
Development and discovery of SSRI drugsDevelopment and discovery of SSRI drugs
... called citalopram. But citalopram can also be viewed as a constrained analogue of paroxetine. Citalopram has the second most ... Citalopram is composed of two enantiomers, (R)- and (S)-, which are mirror images of each other (figure 7). Researches has ... were able to generate a model of the (S)-citalopram binding site in human SERT by combining mutational analysis and comparative ... S)-citalopram is positioned as that the cyanophthalane-. fluorophenyl- and methylaminoprpyl moieties occupy three different sub ...
https://en.wikipedia.org/wiki/Development_and_discovery_of_SSRI_drugs
Serotonin syndromeSerotonin syndrome
Isbister GK, Dawson A, Whyte IM (September 2001). "Citalopram overdose, serotonin toxicity, or neuroleptic malignant syndrome ...
https://en.wikipedia.org/wiki/Serotonin_syndrome
Orally disintegrating tabletOrally disintegrating tablet
Biovail Product Pipeline Citalopram Prescribing Information Ultracet Prescribing Information. ...
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RacemizationRacemization
Jacquot, C.; David, D. J.; Gardier, A. M.; Sánchez, C. (2007). "Escitalopram and citalopram: the unexpected role of the R- ... Likewise, the (S) stereoisomer is much more reactive than the (R) enantiomer in citalopram (Celexa), an antidepressant which ...
https://en.wikipedia.org/wiki/Racemization
Reuptake inhibitorReuptake inhibitor
Chen F, Larsen MB, Sánchez C, Wiborg O (2005). "The S-enantiomer of R,S-citalopram, increases inhibitor binding to the human ... A few of the selective serotonin reuptake inhibitors (SSRIs) such as the dextro-enantiomer of citalopram appear to be ... Ravna AW, Sylte I, Dahl SG (2003). "Molecular mechanism of citalopram and cocaine interactions with neurotransmitter ...
https://en.wikipedia.org/wiki/Reuptake_inhibitor
GRIK4GRIK4
A test of that gene can be made in order to know if a depressed patient will respond to the SSRI citalopram. The GRIK4 gene ... "GRIK4, HTR2A markers indicate reduced risk of nonresponse to citalopram". Science News. Science Daily. Retrieved 2009-01-20. ...
https://en.wikipedia.org/wiki/GRIK4
ReuptakeReuptake
exposed HEK-SERT with citalopram on a long-term basis. They noticed that long-term exposure led to a down-regulation of binding ... found that after removing citalopram from the system, normal levels of SERT binding site expression returned. Depression has ... they were able to quantify that citalopram acted on SERT as an SSRI, and that desipramine had no effect on SERT. In a separate ... They presented SERT with varying doses of either citalopram (an SSRI) or desipramine (an inhibitor of norepinephrine reuptake ...
https://en.wikipedia.org/wiki/Reuptake
CimetidineCimetidine
"Pharmacokinetic interaction study of citalopram and cimetidine in healthy subjects". European Journal of Clinical Pharmacology ...
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DidesmethylcitalopramDidesmethylcitalopram
... the S-enantiomer of citalopram. Like citalopram and escitalopram, didesmethyl(es)citalopram functions as a selective serotonin ... Didesmethylcitalopram is an active metabolite of the antidepressant drug citalopram (racemic). Didesmethylescitalopram is an ...
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Torsades de pointesTorsades de pointes
However, a study, "Evaluation of the FDA Warning Against Prescribing Citalopram at Doses Exceeding 40 mg," reported no ... 2012). "Prolonged QTc interval and torsades de pointes induced by citalopram". Tex. Heart Inst. J. 39 (1): 68-70. PMC 3298934 ... "FDA Drug Safety Communication: Revised recommendations for Celexa (citalopram hydrobromide) related to a potential risk of ... citalopram) above 40 mg per day, considered the maximum allowable dosage, thereby increasing the risk of Torsades. ...
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Rohypnol - Simple English Wikipedia, the free encyclopediaRohypnol - Simple English Wikipedia, the free encyclopedia
"Citalopram in fatal poisoning cases". Forensic Science International 126 (1): 1-6. doi:10.1016/S0379-0738(01)00632-6. PMID ...
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SerenicSerenic
... by citalopram". Neuropsychopharmacology. 33 (5): 1192-205. doi:10.1038/sj.npp.1301491. PMID 17609680. Dumont GJ, Sweep FC, van ...
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S100A10S100A10
"p11 Protein Levels in Patients With Major Depressive Disorder Treated With Citalopram". ClinicalTrials.gov. Akiba S, Hatazawa R ... and determine whether p11 levels in patients are affected by treatment with citalopram (Celexa), a serotonin reuptake inhibitor ...
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Bone morphogenetic protein 7Bone morphogenetic protein 7
2010). "A genomewide association study of citalopram response in major depressive disorder". Biol. Psychiatry. 67 (2): 133-8. ...
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ImipramineImipramine
"Pharmacological properties of the active metabolites of the antidepressants desipramine and citalopram". Eur. J. Pharmacol. 576 ...
https://en.wikipedia.org/wiki/Imipramine
5-HT2A receptor5-HT2A receptor
... so that patients suffering from major depressive disorder and treated with citalopram may benefit more than others if they have ... "Genetic markers of suicidal ideation emerging during citalopram treatment of major depression". The American Journal of ...
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CitalopramSerotonin Uptake InhibitorsAntidepressive Agents, Second-GenerationAntidepressive AgentsSerotonin Plasma Membrane Transport ProteinsDothiepinSerotoninFluoxetineParoxetineCyclohexanolsAntidepressive Agents, TricyclicClomipramineNorepinephrine Plasma Membrane Transport ProteinsSerotonin AntagonistsReceptor, Serotonin, 5-HT1AImipramineDepressive Disorder, MajorForensic PathologyHindlimb SuspensionTryptophan Hydroxylase8-Hydroxy-2-(di-n-propylamino)tetralinMianserinSertralineSerotonin Receptor Agonistsp-ChloroamphetamineFluvoxamineDepressive DisorderDrug OverdoseRaphe NucleiAdrenergic Uptake InhibitorsSerotonin 5-HT1 Receptor AntagonistsGastric LavageForensic ToxicologyNarcoticsNalorphineDrug and Narcotic ControlLevorphanolDrugs, GenericArrhythmias, CardiacUnited States Food and Drug AdministrationScopolamine HydrobromideEthylaminesVerbal BehaviorCognitionNeuropsychological TestsCognition DisordersTreatment OutcomeIntelligence
Is Citalopram considered a narcotic?Is Citalopram considered a narcotic?
... citalopram, narcotic - Answer: To my knowledge, citalopram is not considered a narcotic. I have been on ... ... Home › Q & A › Questions › Is Citalopram considered a.... Is Citalopram considered a narcotic?. Asked. 18 Dec 2012 by ... Side Effects of Citalopram (detailed). Search for questions. Still looking for answers? Try searching for what you seek or ask ... To my knowledge, citalopram is not considered a narcotic. I have been on drug for several years now. It is a very good drugs ...
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What is citalopram used for? | Reference.comWhat is citalopram used for? | Reference.com
Citalopram is the generic version of Celexa and is... ... Citalopram is a selective serotonin reuptake inhibitor, or SSRI ... What is the usual oral dosage of citalopram for depression?. A: The usual adult oral dosage of citalopram for depression is 20 ... Citalopram is a selective serotonin reuptake inhibitor, or SSRI, that is commonly prescribed for the treatment of depression, ... Although the exact mechanism by which citalopram works is not completely understood, it is widely prescribed and can provide ...
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FDA Warns Against High-Dose Citalopram | MedPage TodayFDA Warns Against High-Dose Citalopram | MedPage Today
... increased risk of cardiac arrhythmias and a lack of therapeutic benefit associated with high doses of the SSRI citalopram ... Patients currently taking citalopram at doses higher than 40 mg/day should not stop the drug abruptly, but should talk to their ... Package inserts for citalopram, which is also available in generic forms, will be rewritten to include the new information, the ... FDA Warns Against High-Dose Citalopram. by John Gever, Senior Editor, MedPage Today August 24, 2011 ...
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Citalopram to Enhance Cognition in HD - Full Text View - ClinicalTrials.govCitalopram to Enhance Cognition in HD - Full Text View - ClinicalTrials.gov
Experimental: Citalopram 20mg daily citalopram. Drug: 20mg daily citalopram a selective serotonin reuptake inhibitor (SSRI) ... Drug Information available for: Citalopram hydrobromide Citalopram Escitalopram oxalate Genetic and Rare Diseases Information ... Results of the citalopram to enhance cognition in Huntington disease trial. Mov Disord. 2014 Mar;29(3):401-5. doi: 10.1002/mds. ... Citalopram to Enhance Cognition in HD (CIT-HD). This study has been completed. ...
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View source for Citalopram - encyclopedia article - CitizendiumView source for Citalopram - encyclopedia article - Citizendium
subpages}} {{TOC,right}} In [[psychiatry]], citalopram is a [[second-generation antidepressant]] for treating [[major ... Citalopram is metabolised by [[cytochrome P-450]] CYP3A4 and [[Cytochrome P-450 CYP2C19,CYP2C19]]. ===Excretion=== ==Toxicity ... citalopram hydrobromide) - Drug Safety Communication: Revised Recommendations, Potential Risk of Abnormal Heart Rhythms ,author ...
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NG Citalopram - Uses, Side Effects, Interactions - MedBroadcast.comNG Citalopram - Uses, Side Effects, Interactions - MedBroadcast.com
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Impact of the antidepressant citalopram on the behaviour of two different life stages of brown trout [PeerJ]Impact of the antidepressant citalopram on the behaviour of two different life stages of brown trout [PeerJ]
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Citalopram - WikipediaCitalopram - Wikipedia
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Citalopram enhances cocaines subjective effects in rats. - PubMed - NCBICitalopram enhances cocaine's subjective effects in rats. - PubMed - NCBI
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AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaHealth Care
CitalopramSerotonin Uptake InhibitorsAntidepressive Agents, Second-GenerationAntidepressive AgentsSerotonin Plasma Membrane Transport ProteinsDothiepinSerotoninFluoxetineParoxetineCyclohexanolsAntidepressive Agents, TricyclicClomipramineNorepinephrine Plasma Membrane Transport ProteinsSerotonin AntagonistsReceptor, Serotonin, 5-HT1AImipramineDepressive Disorder, MajorForensic PathologyHindlimb SuspensionTryptophan Hydroxylase8-Hydroxy-2-(di-n-propylamino)tetralinMianserinSertralineSerotonin Receptor Agonistsp-ChloroamphetamineFluvoxamineDepressive DisorderDrug OverdoseRaphe NucleiAdrenergic Uptake InhibitorsSerotonin 5-HT1 Receptor AntagonistsGastric LavageForensic ToxicologyNarcoticsNalorphineDrug and Narcotic ControlLevorphanolDrugs, GenericArrhythmias, CardiacUnited States Food and Drug AdministrationScopolamine HydrobromideEthylaminesVerbal BehaviorCognitionNeuropsychological TestsCognition DisordersTreatment OutcomeIntelligence
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SSRI4
  • Citalopram is a selective serotonin reuptake inhibitor, or SSRI, that is commonly prescribed for the treatment of depression, according to WebMD. (reference.com)
  • Citing increased risk of cardiac arrhythmias and a lack of therapeutic benefit associated with high doses of the selective serotonin reuptake inhibitor (SSRI) citalopram hydrobromide (Celexa), the FDA has reduced the recommended maximum to 40 mg/day. (medpagetoday.com)
  • Citalopram is known as a selective serotonin reuptake inhibitor (SSRI). (ndclist.com)
  • Citalopram is an SSRI commonly prescribed during pregnancy. (ogscience.org)
Depression6
  • Although the exact mechanism by which citalopram works is not completely understood, it is widely prescribed and can provide marked improvement of behavior, outlook and mood for those suffering from depression, according to WebMD. (reference.com)
  • What is the usual oral dosage of citalopram for depression? (reference.com)
  • The usual adult oral dosage of citalopram for depression is 20 milligrams once a day, and the dose is increased to 40 milligrams if a doctor deems it neces. (reference.com)
  • I was put on citalopram for my anxiety and depression . (patient.info)
  • Objective To study the association of genetic variants in 10 genes that regulate the CRF and arginine vasopressin systems with treatment response to citalopram in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) sample (N = 1768). (scialert.net)
  • The selective serotonin reuptake inhibitors citalopram improves IBS symptoms, independent of effects on depression, finds the latest issue of Gut . (gastrohep.com)
Antidepressant2
  • Additionally, in a stressful artificial swimming measurement device, brown trout larvae displayed the anxiolytic effect of the antidepressant by reduced swimming activity during this stress situation, already at concentrations of 100 µg/L citalopram. (peerj.com)
  • Overall, we could trace the pharmacological mode of action of the antidepressant citalopram in the non-target organism brown trout in two different life stages. (peerj.com)
Anxiety2
  • During the exposure, both larvae and juvenile fish exposed to the highest test concentration of citalopram (1 mg/L) had higher swimming activity and spent longer in the upper part of the aquaria compared to control fish, which is an indicator for decreased anxiety. (peerj.com)
  • What dose of citalopram are you on, and have you tried breathing techniques to calm the anxiety. (patient.info)
Placebo4
  • Executive Function Composite Score Comparing Visit 2 (Week 0) to Visits 5 (Week 12) & 6 (Week 15) for the Citalopram Cohort Versus Placebo Cohort. (clinicaltrials.gov)
  • Change Calculation Details: Compares change in executive functioning performance from visit 2 (week 0) to the weighted average of visits 5 (week 12) & 6 (week 15) for the citalopram versus placebo cohort. (clinicaltrials.gov)
  • The research team conducted a crossover trial comparing 6 weeks of treatment with the selective serotonin reuptake inhibitors citalopram with placebo. (gastrohep.com)
  • Dr Tack's team concluded, The selective serotonin reuptake inhibitors citalopram significantly improves irritable bowel syndrome symptoms, including abdominal pain, compared with placebo. (gastrohep.com)
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Abdominal Pain1
  • The research team found after 3 and 6 weeks of treatment that citalopram improved abdominal pain, and bloating. (gastrohep.com)
Celexa citalopram4
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Patients4
  • Consequently, the agency recommended that patients with these conditions should undergo regular electrocardiography if given citalopram, and hypokalemia and hypomagnesemia should be corrected before starting patients on the drug. (medpagetoday.com)
  • Patients currently taking citalopram at doses higher than 40 mg/day should not stop the drug abruptly, but should talk to their doctors about lowering the dose, and should seek treatment immediately for irregular heartbeats, shortness of breath, fainting, or dizziness. (medpagetoday.com)
  • However, physicians should carefully weigh the benefits against the potential risks of citalopram use, and counsel patients accordingly. (ogscience.org)
  • The patients were given citalopram 20 mg for 3 weeks then 40 mg for 3 weeks. (gastrohep.com)
Lexapro1
  • The FDA did not indicate that the cardiac effects were an issue with escitalopram (Lexapro), which is the S- enantiomer of citalopram -- suggesting that the arrhythmias stem from the latter's R -enantiomer. (medpagetoday.com)
Medications1
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Doses1
  • As a result of this thorough QT study, FDA has determined that citalopram causes dose-dependent QT interval prolongation and should no longer be used at doses above 40 mg per day," the agency said in a drug safety communication. (medpagetoday.com)
Symptoms1
  • Impact of symptoms on daily life, and overall well being compared was also improved after 3 and 6 weeks with citalopram. (gastrohep.com)
Pills1
Tablets usp2
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Celexa52
  • Citalopram is a selective serotonin reuptake inhibitor (SSRI) antidepressant drug that is sold in the United States under brand name Celexa. (encyclopedia.com)
  • Citalopram (marketed as Celexa) is included in the class of drugs called selective serotonin reuptake inhibitors (SSRIs). (fda.gov)
  • Citalopram (brand names: Celexa, Cipramil and others) is an antidepressant drug of the selective serotonin reuptake inhibitor (SSRI) class. (wikipedia.org)
  • Citalopram is the generic version of Celexa and is formulated to restore the balance of serotonin in the brain. (reference.com)
  • Citing increased risk of cardiac arrhythmias and a lack of therapeutic benefit associated with high doses of the selective serotonin reuptake inhibitor (SSRI) citalopram hydrobromide (Celexa), the FDA has reduced the recommended maximum to 40 mg/day. (medpagetoday.com)
  • The drug celexa, which goes by the generic name citalopram, is prescribed for patients suffering from major depression that lasts more than two weeks. (medindia.net)
  • What Is Citalopram (Celexa)? (everydayhealth.com)
  • Citalopram is the generic form of the brand-name antidepressant Celexa, which is used to treat depression . (everydayhealth.com)
  • What are the possible side effects of citalopram (CeleXA)? (emedicinehealth.com)
  • Citalopram oral is the generic name for the brand-name drug, Celexa. (sharecare.com)
  • Citalopram is the active ingredient in Celexa. (sharecare.com)
  • If you are looking for less costly alternative to Celexa, ask your doctor or pharmacist for generic citalopram, which is made by 10 different manufacturers and comes in three different strengths. (sharecare.com)
  • Citalopram ( Cipramil, Celexa ): do atypical features affect outcome in depressed outpatients? (biopsychiatry.com)
  • Tell me about your experience on Citalopram (Celexa / Cipramil). (metafilter.com)
  • I'm about to start a course of Citalopram (Celexa / Cipramil). (metafilter.com)
  • If you have any experience on Citalopram (Celexa) or similar SSRIs, is there anything you wish you'd known before starting? (metafilter.com)
  • citalopram/Celexa is a terrific SSRI. (metafilter.com)
  • What is the comparative effectiveness of citalopram (Celexa), methylphenidate (Ritalin), or both for the treatment of depression among older patients? (aafp.org)
  • Now, a randomized controlled trial has shown that citalopram (Celexa), an SSRI with little effect on tamoxifen metabolism, cuts the frequency and severity of hot flashes by at least 50% in postmenopausal women. (harvard.edu)
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  • Here, we look at Citalopram (Celexa) and how it affects pregnant women. (momjunction.com)
  • Citalopram or Celexa is the brand name of a prescription anti-depressant. (momjunction.com)
  • Citalopram, which is marketed as Celexa, was the third-highest prescribed drug in the United States in 2013, with around 39 million prescriptions. (momjunction.com)
  • Known to belong to a category of anti-depressants, which are commonly referred to as Selective Serotonin Reuptake Inhibitors (SSRIs), taking Celexa, which is a common brand name for Citalopram, during your pregnancy, may increase the possibility of birth defects in your child. (momjunction.com)
  • On a scale of 5, Celexa, or Citalopram scored a C because it has harmful effects on the fetus and is linked to an increased risk of birth defects in some animal studies. (momjunction.com)
  • It is generically known as citalopram hydrobromide (Celexa). (avalonpharmacy.com)
  • On the first day she met Jeannie, Dr. O. prescribed 20 mg/day of Celexa (citalopram). (rxisk.org)
  • When Jeannie's mother Marian learned this, and the dosage of Celexa that Jeannie had been taking, she filed a lawsuit against Dr. P. During the May 2011 trial, Marian's lawyer had an expert testify that citalopram is known to exacerbate heart conditions. (rxisk.org)
  • Celexa (Citalopram) is a selective Serotonin Reuptake Inhibitor used to treat depression. (medformula.com)
  • A group of researchers recently investigated the possibility that an antidepressant, citalopram (Celexa), may be an alternative choice. (thecarlatreport.com)
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  • Celexa should not be used by pregnant/nursing women or children as well as by the patients having demonstrated a reaction of hypersensitivity to Citalopram. (generic4all.com)
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  • A variation in a gene called GRIK4 appears to make people with depression more likely to respond to the medication citalopram (Celexa) than are people without the variation, a study by the National Institute of Mental Health (NIMH), part of the National Institutes of Health , has found. (netdoc.com)
Hydrobromide19
  • Citalopram hydrobromide is an orally administered selective serotonin reuptake inhibitor (SSRI) with a chemical structure unrelated to that of other SSRIs or of tricyclic, tetracyclic, or other available antidepressant agents. (nih.gov)
  • Citalopram hydrobromide occurs as a fine, white to off-white powder. (nih.gov)
  • Citalopram hydrobromide is sparingly soluble in water and soluble in ethanol. (nih.gov)
  • Citalopram hydrobromide is available as tablets. (nih.gov)
  • Citalopram 20 mg and 40 mg tablets are scored biconvex capsule shaped film coated tablets containing citalopram hydrobromide in strengths equivalent to 20 mg or 40 mg citalopram base. (nih.gov)
  • The mechanism of action of citalopram hydrobromide as an antidepressant is presumed to be linked to potentiation of serotonergic activity in the central nervous system (CNS) resulting from its inhibition of CNS neuronal reuptake of serotonin (5-HT). (nih.gov)
  • Do not take Celapram if you are allergic to medicines containing citalopram hydrobromide (e.g. (news-medical.net)
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  • Anyone considering the use of citalopram hydrobromide tablets or any other antidepressant in a child, adolescent or young adult must balance this risk with the clinical need. (nih.gov)
  • Each white-to-off-white, oval-shaped, scored, film-coated tablet, imprinted 'C' on one side and '10' on the other, contains 10 mg of citalopram (as citalopram hydrobromide). (medbroadcast.com)
  • Each white, oval-shaped, scored, film-coated tablet, imprinted on the scored side with 'N' on the left side and 'C' on the right side and imprinted on the non-scored side with '20', contains 20 mg of citalopram (as citalopram hydrobromide). (medbroadcast.com)
  • Citalopram hydrobromide, USP occurs as a white to almost white crystalline powder. (prescriptiondrugs.com)
  • Citalopram oral solution, USP contains citalopram hydrobromide, USP equivalent to 2 mg/mL citalopram base. (prescriptiondrugs.com)
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Depression42
  • Citalopram is approved by the United States Food and Drug Administration ( FDA ) for the treatment of depression. (encyclopedia.com)
  • The daily dosage of citalopram for depression ranges from 20 - 60 mg. (encyclopedia.com)
  • Citalopram is used to treat depression. (medlineplus.gov)
  • Basically I've been on citalopram a long time and had a severe depression? (drugs.com)
  • Evidence for effectiveness of citalopram for treating depression in children is uncertain. (wikipedia.org)
  • Although the exact mechanism by which citalopram works is not completely understood, it is widely prescribed and can provide marked improvement of behavior, outlook and mood for those suffering from depression, according to WebMD. (reference.com)
  • What is the usual oral dosage of citalopram for depression? (reference.com)
  • The usual adult oral dosage of citalopram for depression is 20 milligrams once a day, and the dose is increased to 40 milligrams if a doctor deems it neces. (reference.com)
  • Citalopram is a selective serotonin reuptake inhibitor indicated for the treatment of depression . (selfgrowth.com)
  • Standardized depression scores were 67 percent more likely to drop by half on citalopram than placebo, and the chance of depression remitting was almost doubled. (medindia.net)
  • Says Dr. Lesperance, "Citalopram or sertraline, as previously shown in [a different trial], plus clinical management should be considered for the initial acute-phase treatment for major depression in patients with coronary artery disease. (medindia.net)
  • Phenotypes to be measured before and after the initiation of citalopram or escitalopram therapy will include determinations of serum citalopram and metabolite concentrations, treatment response as measured by Hamilton Rating Scale for Depression indices, and number and severity of side effects as determined by structured questionnaires. (clinicaltrials.gov)
  • Hi, I am on Citalopram 40mg daily for my depression. (minddisorders.com)
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  • We explored this hypothesis in a patient-level post hoc-analysis including all industry-sponsored, Food and Drug Administration-registered placebo-controlled trials of citalopram or paroxetine in adult major depression that used the Hamilton Depression Rating Scale (HDRS) and included a week 6 symptom assessment ( n =15). (nature.com)
  • Combined treatment with citalopram plus methylphenidate provided faster improvement of depression symptoms in older patients with unipolar depression. (aafp.org)
  • This randomized controlled trial of older patients with depression compared citalopram plus placebo (n = 48), methylphenidate plus placebo (n = 47), and both active treatments (n = 47). (aafp.org)
  • This side effect report can indicate a possible existence of increased vulnerability to Citalopram treatment in patients suffering from depression , resulting in Abdominal Pain . (patientsville.com)
  • depression started Citalopram (citalopram) treatment (dosage: 20 Mg Once A Day And Gradually Reducing Doses Down To Zero, Oral) on Jun 10, 2011. (patientsville.com)
  • depression and used Citalopram (dosage: Gradually Reducing Doses Down To Zero. (patientsville.com)
  • Citalopram treats depression. (medicineshoppe.com)
  • Efficacy of citalopram in the prevention of recurrent depression in elderly patients: placebo-controlled study of maintenance therapy. (annals.org)
  • In elderly outpatients with unipolar major depression who have responded to acute and continuation treatment with citalopram, is prophylactic treatment with citalopram more effective than placebo for recurrence prevention? (annals.org)
  • 121 outpatients ≥ 65 years of age (mean age 75 y, 77% women) with unipolar major depression ( Diagnostic and Statistical Manual of Mental Disorders, 4th edition [DSM-IV] , 296.2x or 296.3x and Montgomery Åsberg Depression Rating Scale [MADRS] score ≥ 22) who responded to acute and continuation treatment with citalopram (20 to 40 mg) for 8 and 16 weeks, respectively. (annals.org)
  • Citalopram is used for treating depression. (quietcorners.com)
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  • Citalopram is one such antidepressant that helps boost serotonin levels in your body and eases your depression. (momjunction.com)
  • Citalopram medication is an antidepressant drug used to relieve depression. (avalonpharmacy.com)
  • Citalopram is used to treat anxiety, panic disorder and depression. (avalonpharmacy.com)
  • The efficacy of citalopram, 20 to 60 mg/day, in relapse prevention in major depression was demonstrated in 6-month placebo-controlled studies. (psychiatrist.com)
  • and (iii) evaluating these tagging SNPs for association with response to the selective serotonin reuptake inhibitor citalopram in an independent sample of participants who are enrolled in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) clinical study (N=1953). (ovid.com)
  • Citalopram is a selective serotonin reuptake inhibitor, balances levels of serotonin in the brain and heals major depression associated with mood disorders. (generic4all.com)
  • The discovery that a variation in a serotonin -related gene could affect response to citalopram was not entirely surprising, since the serotonin system is known to be involved in depression. (netdoc.com)
20mg8
  • As they are essentially the same med there are usually few issues with switching from one to the other so I'm wondering if you could take 10mg escitalopram - the equivalent of 20mg citalopram - without compromising tamoxifen effectiveness. (nomorepanic.co.uk)
  • I've been taking citalopram for about 3 weeks now - working my way up from 10mg to 20mg. (socialanxietysupport.com)
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Escitalopram11
  • In the National Institute for Health and Clinical Excellence ranking of 10 antidepressants for efficacy and cost-effectiveness citalopram is fifth in effectiveness (after mirtazapine, escitalopram, venlafaxine, and sertraline) and fourth in cost-effectiveness. (wikipedia.org)
  • In another analysis by Cipriani, citalopram was found to be more efficacious than paroxetine and reboxetine, and more acceptable than tricyclics, reboxetine, and venlafaxine, but less efficacious than escitalopram. (wikipedia.org)
  • A meta-analysis, including studies with fluoxetine, paroxetine, sertraline, escitalopram, and citalopram versus placebo, showed SSRIs to be effective in reducing symptoms of premenstrual syndrome, whether taken continuously or just in the luteal phase. (wikipedia.org)
  • The FDA did not indicate that the cardiac effects were an issue with escitalopram (Lexapro), which is the S- enantiomer of citalopram -- suggesting that the arrhythmias stem from the latter's R -enantiomer. (medpagetoday.com)
  • Dok je citalopram na tržištu u obliku bromovodonika , escitalopram se prodaje kao oksalatna so (hidrooksalat). (wikipedia.org)
  • Interesting as the recommendation seems to be that patients on SSRIs/SNRIs which strongly inhibit the CYP2D6 liver enzyme which converts tamoxifen to its active metabolite should be switched to citalopram, or escitalopram. (nomorepanic.co.uk)
  • BTW-escitalopram seems to be a weaker CYP2D6 inhibitor than its parent compound citalopram. (nomorepanic.co.uk)
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  • High-Dose Citalopram and Escitalopram: Undeserved Bad Rap? (thecarlatreport.com)
Serotonin13
  • Serious side effects called serotonin syndrome have resulted from the combination of antidepressants such as citalopram and members of another class of antidepressants known as monoamine oxidase (MAO) inhibitors. (encyclopedia.com)
  • Citalopram is in a class of antidepressants called selective serotonin reuptake inhibitors (SSRIs). (medlineplus.gov)
  • Citalopram theoretically causes side effects by increasing the concentration of serotonin in other parts of the body (e.g., the intestines). (wikipedia.org)
  • Citalopram is in a class of antidepressants known as selective serotonin reuptake inhibitors (SSRIs) , which work on neurotransmitters (the chemicals that nerves in the brain use to communicate with each other). (everydayhealth.com)
  • Citalopram is thought to work by increasing serotonin levels . (everydayhealth.com)
  • Citalopram belongs to a group of medications called selective serotonin reuptake inhibitors (SSRIs). (medbroadcast.com)
  • Citalopram is an antidepressant in a group of drugs called selective serotonin reuptake inhibitors ( SSRIs ). (emedicinehealth.com)
  • Target brain sites of the anxiolytic effect of citalopram, a selective serotonin reuptake inhibitor. (abcam.com)
  • Citalopram--pharmacological profile of a specific serotonin uptake inhibitor with antidepressant activity. (abcam.com)
  • Citalopram (Lu 10-171), a new bicyclic phthalane derivative, is an extremely potent inhibitor of neuronal serotonin (5-HT) uptake but has no effect on the uptake of noradrenaline(NA) and dopamine (DA) and no antagonistic activity towards 5-HT, histamine, gamma aminobutyric acid (GABA), acetylcholine, and morphine receptors. (selleckchem.com)
  • Citalopram is in a class of drugs called selective serotonin reuptake inhibitors (SSRIs). (medicineshoppe.com)
  • Because the use of serotonin reuptake inhibitors is becoming more popular among elderly depressed patients the present paper and other reported cases emphasize the need of greater awareness of the development of this serious complication and suggest that sodium serum levels should be monitored closely in elderly patients during treatment with citalopram. (antidepressantsfacts.com)
  • We combined computational modeling with pharmacological manipulation in 90 healthy human volunteers, using levodopa and citalopram to affect dopamine and serotonin, respectively. (springer.com)
Placebo10
  • Executive Function Composite Score Comparing Visit 2 (Week 0) to Visits 5 (Week 12) & 6 (Week 15) for the Citalopram Cohort Versus Placebo Cohort. (clinicaltrials.gov)
  • Change Calculation Details: Compares change in executive functioning performance from visit 2 (week 0) to the weighted average of visits 5 (week 12) & 6 (week 15) for the citalopram versus placebo cohort. (clinicaltrials.gov)
  • The objective of this study was to explore the efficacy of combination therapy with citalopram plus omega-3 fatty acids versus citalopram plus placebo (olive oil) in the initial treatment of individuals with major depressive disorder (MDD). (nih.gov)
  • Forty-two subjects participated in this 9-week randomized, masked, placebo-controlled study of combination therapy (two 1 g capsules containing a blend of 900 mg of eicosapentaenoic acid, 200 mg of and docosahexaenoic acid, and 100 mg of other omega-3 fatty acids twice daily plus citalopram) versus monotherapy (two 1 g capsules of olive oil per day plus citalopram) treatment of MDD. (nih.gov)
  • 1) Thirty-one subjects were given placebo for 1 week and then citalopram, 20 to 40 mg/day, for 2 months. (psychiatrist.com)
  • The primary analyses, which compared completers on active treatment without early adverse events to completers on placebo (with or without adverse events) with respect to reduction in the HDRS depressed mood item showed larger symptom reduction in patients given active treatment, the effect sizes being 0.48 for citalopram and 0.33 for paroxetine. (nature.com)
  • The finding that both paroxetine and citalopram are clearly superior to placebo also when not producing adverse events, as well as the lack of association between adverse event severity and response, argue against the theory that antidepressants outperform placebo solely or largely because of their side effects. (nature.com)
  • If response was insufficient at four weeks, citalopram (or placebo) was also increased from 20 to 40 mg or, in some cases, 60 mg daily. (aafp.org)
  • Remission rates were 30% among patients who received placebo instead of citalopram, 42% with 20 mg of citalopram, 56% with 40 mg, and 69% with 60 mg. (aafp.org)
  • We found that, after administration of levodopa, action learning was less affected by outcome valence when compared with the placebo and citalopram groups. (springer.com)
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Antidepressants6
  • A small number of children, teenagers, and young adults (up to 24 years of age) who took antidepressants ('mood elevators') such as citalopram during clinical studies became suicidal (thinking about harming or killing oneself or planning or trying to do so). (medlineplus.gov)
  • You should know that your mental health may change in unexpected ways when you take citalopram or other antidepressants even if you are an adult over 24 years of age. (medlineplus.gov)
  • The FDA requires citalopram to carry a black-box warning because some children, teenagers, and young adults (up to 24 years of age) who took antidepressants such as citalopram during clinical studies had suicidal thoughts and behavior. (everydayhealth.com)
  • There are anecdotal reports that citalopram, like other antidepressants, has been abused by some people to "get high" or experience a sense of euphoria. (everydayhealth.com)
  • Here we report X-ray crystallographic structures of human SERT at 3.15 Å resolution bound to the antidepressants (S)-citalopram or paroxetine. (rcsb.org)
  • Bipolar disorder and is given antidepressants on their own (citalopram) what sort of effect is it going to have? (healthtap.com)
Precautions1
Selective2
  • Because mirtazapine blocks α 2 -adrenoreceptors, the combined effect of atipamezole, a selective α 2 receptor antagonist, with citalopram was also examined. (dovepress.com)
  • We selected the forced swimming test, a mouse model used to assess the antidepressant potential of drugs, and neurochemical techniques to study strain differences in the response to citalopram, a selective 5-HT reuptake inhibitor. (jneurosci.org)
Effect of citalopram2
  • Pretreatment with tryptophan raised 5-HTP accumulation and reinstated the antidepressant-like effect of citalopram in DBA/2J and BALB/c mice, whereas pharmacological inhibition of 5-HT synthesis prevented the effect of citalopram in C57BL/6J and 129/Sv mice. (jneurosci.org)
  • Nevertheless, Creed claims that this study provides useful information on the effect of citalopram on the primary outcome measure-number of days per week with abdominal pain. (bmj.com)
Response to citalopram3
  • Thirty-six subjects had a stable response to citalopram and remained in the continuation treatment with citalopram, 40 mg/day, for 4 months as outpatients. (psychiatrist.com)
  • It appears that genetic variation in these five genes has a marginal effect on response to citalopram, although a previously observed association was supported and awaits replication in an independent sample. (ovid.com)
  • The 23 percent increase in likelihood of response to citalopram occurred in people who carried the favorable variations in both copies of both of the genes. (netdoc.com)
Patients19
  • Patients with history of mania, suicide attempts, or seizure disorders should start citalopram with caution and only under close physician supervision. (encyclopedia.com)
  • More than 15% of patients develop insomnia while taking citalopram. (encyclopedia.com)
  • Nausea and dry mouth occur in about 20% patients being treated with citalopram. (encyclopedia.com)
  • In general, patients do not experience weight gain or loss after starting citalopram. (encyclopedia.com)
  • If sexual side effects continue, the dose of citalopram may be reduced, patients can also have drug holidays where the weekend dose is either decreased or skipped, or they can discuss with their physician the risks and benefits of switching to another antidepressant. (encyclopedia.com)
  • Patients should always inform all their health care providers, including dentists, that they are taking citalopram. (encyclopedia.com)
  • Citalopram is not approved for use in pediatric patients. (nih.gov)
  • Consequently, the agency recommended that patients with these conditions should undergo regular electrocardiography if given citalopram, and hypokalemia and hypomagnesemia should be corrected before starting patients on the drug. (medpagetoday.com)
  • Patients currently taking citalopram at doses higher than 40 mg/day should not stop the drug abruptly, but should talk to their doctors about lowering the dose, and should seek treatment immediately for irregular heartbeats, shortness of breath, fainting, or dizziness. (medpagetoday.com)
  • Omega-3 fatty acid augmentation of citalopram treatment for patients with major depressive disorder. (nih.gov)
  • Depressed patients with atypical features are less likely to remit with citalopram than those without atypical features. (biopsychiatry.com)
  • Citalopram may improve fatigue and symptoms associated with fatigue for some patients. (psychiatrist.com)
  • This finding indicates that some patients can be more vulnerable to developing Citalopram (citalopram) side effects, such as Abdominal Pain . (patientsville.com)
  • 66 patients with major depressive disorder accompanied by anxious distress were randomly assigned to receive either saffron (30 mg/day) or citalopram (40 mg/day) for 6 weeks. (nih.gov)
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  • At the time of recovery, 32 patients gave their written informed consent before entering the 24-month maintenance period with citalopram, 20 mg/day. (psychiatrist.com)
  • What is relevant for patients as well as physicians is the risk of reduction in the number of days with abdominal pain after citalopram treatment. (bmj.com)
  • In the newest study, researchers examined the genetic material of more of the patients who had participated in STAR*D, for a total of 1,816 samples, and repeated the comparison of DNA from citalopram responders and nonresponders. (netdoc.com)
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  • CYP2D6 and CYP2C19 are proteins in your body that are involved in the elimination of citalopram and other drugs from your body. (medicineshoppe.com)
  • Citalopram reacts adversely with antiplatelet drugs such as warfarin (Coumadin) non-steroidal anti-inflammatory medicines (NSAIDs) such as ibuprofen and also blood thinners like as cladogram (Plavix). (avalonpharmacy.com)
  • Individuals taking MAOI drugs such as isocarboxazid (Marplan), selegiline Eldepryl, linezolid (Zyvox), phenelzine (Nardil), tranylcypromine (Parnate), Emsam or Zelapar should not use citalopram one week before or after their last dosage. (avalonpharmacy.com)
  • There is considerable evidence that pharmaceutical companies have known about these risks for years and sometimes before drugs like citalopram are marketed. (rxisk.org)
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Active ingredient1
  • Citalopram (GenRx) is a medicine containing the active ingredient(s) citalopram. (healthdirect.gov.au)
Efficacy2
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  • The authors tested the efficacy of citalopram, 40 mg/day, in relapse prevention over a 4-month period and citalopram, 20 mg/day, in recurrence prevention over a 24-month period. (psychiatrist.com)
Dose of citalopram3
  • Your doctor may start you on a low dose of citalopram and gradually increase your dose, not more often than once a week. (medlineplus.gov)
  • Your doctor may adjust your dose of citalopram if you are a poor metabolizer. (medicineshoppe.com)
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Levels of citalopram3
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  • If you are a poor metabolizer, the levels of citalopram in your blood can become too high. (medicineshoppe.com)
  • Because there were no strain differences in catecholamine synthesis, locomotor activity, and brain levels of citalopram at the end of the behavioral test, the results suggest that the failure of citalopram to reduce immobility time in DBA/2J and BALB/c mice is attributable to genotype-dependent impairment of 5-HT synthesis. (jneurosci.org)
Major depressi1
  • Fifty inpatients with recurrent major depressive disorder (DSM-IV criteria) who had had at least one depressive episode during the 18 months preceding the index episode were openly treated with citalopram, 40 mg/day. (psychiatrist.com)
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Nausea1
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Mood1
  • I've been on Citalopram (currently on 30 mg) for almost two months now and have noticed some drastic changes in my mood. (socialanxietysupport.com)
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Possible side effects of citalopram1
Racemic mixture1
  • Citalopram is a racemic mixture (50/50), and the inhibition of 5-HT reuptake by citalopram is primarily due to the (S)-enantiomer. (nih.gov)
Daily dosage of citalopram1
  • Note that the U.S. Food and Drug Administration currently recommends a 20-mg maximum daily dosage of citalopram. (aafp.org)
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Therapeutic2
  • Citalopram is considered safe and well tolerated in the therapeutic dose range. (wikipedia.org)
  • Citalopram is devoid of cardiotoxic effects even when animals are exposed to concentrations far above the therapeutic level. (selleckchem.com)
Warnings1
  • There are fda warnings about specific cardiac risks with citalopram so just make sure the prescribing physician is monitoring/aware of that. (healthtap.com)
Stop taking cit2
  • Do not stop taking citalopram without talking to your doctor. (medlineplus.gov)
  • If it becomes necessary for you to stop taking citalopram, ask your doctor to advise you how best to gradually reduce the dose to avoid withdrawal effects. (medbroadcast.com)
Version of citalopram1
Panic disorder1
  • Citalopram is licensed in the UK and other European countries for panic disorder, with or without agoraphobia. (wikipedia.org)
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