Cisapride: A substituted benzamide used for its prokinetic properties. It is used in the management of gastroesophageal reflux disease, functional dyspepsia, and other disorders associated with impaired gastrointestinal motility. (Martindale The Extra Pharmacopoeia, 31st ed)Digestive System Physiological Phenomena: Properties and processes of the DIGESTIVE SYSTEM as a whole or of any of its parts.Digestion: The process of breakdown of food for metabolism and use by the body.Digestive System: A group of organs stretching from the MOUTH to the ANUS, serving to breakdown foods, assimilate nutrients, and eliminate waste. In humans, the digestive system includes the GASTROINTESTINAL TRACT and the accessory glands (LIVER; BILIARY TRACT; PANCREAS).Gastrointestinal Agents: Drugs used for their effects on the gastrointestinal system, as to control gastric acidity, regulate gastrointestinal motility and water flow, and improve digestion.Pasteurellosis, Pneumonic: Bovine respiratory disease found in animals that have been shipped or exposed to CATTLE recently transported. The major agent responsible for the disease is MANNHEIMIA HAEMOLYTICA and less commonly, PASTEURELLA MULTOCIDA or HAEMOPHILUS SOMNUS. All three agents are normal inhabitants of the bovine nasal pharyngeal mucosa but not the LUNG. They are considered opportunistic pathogens following STRESS, PHYSIOLOGICAL and/or a viral infection. The resulting bacterial fibrinous BRONCHOPNEUMONIA is often fatal.Ships: Large vessels propelled by power or sail used for transportation on rivers, seas, oceans, or other navigable waters. Boats are smaller vessels propelled by oars, paddles, sail, or power; they may or may not have a deck.Fatigue Syndrome, Chronic: A syndrome characterized by persistent or recurrent fatigue, diffuse musculoskeletal pain, sleep disturbances, and subjective cognitive impairment of 6 months duration or longer. Symptoms are not caused by ongoing exertion; are not relieved by rest; and result in a substantial reduction of previous levels of occupational, educational, social, or personal activities. Minor alterations of immune, neuroendocrine, and autonomic function may be associated with this syndrome. There is also considerable overlap between this condition and FIBROMYALGIA. (From Semin Neurol 1998;18(2):237-42; Ann Intern Med 1994 Dec 15;121(12): 953-9)Pleurodynia, Epidemic: An acute, febrile, infectious disease generally occurring in epidemics. It is usually caused by coxsackieviruses B and sometimes by coxsackieviruses A; echoviruses; or other enteroviruses.Bipolar Disorder: A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence.Attention Deficit Disorder with Hyperactivity: A behavior disorder originating in childhood in which the essential features are signs of developmentally inappropriate inattention, impulsivity, and hyperactivity. Although most individuals have symptoms of both inattention and hyperactivity-impulsivity, one or the other pattern may be predominant. The disorder is more frequent in males than females. Onset is in childhood. Symptoms often attenuate during late adolescence although a minority experience the full complement of symptoms into mid-adulthood. (From DSM-V)Gastroesophageal Reflux: Retrograde flow of gastric juice (GASTRIC ACID) and/or duodenal contents (BILE ACIDS; PANCREATIC JUICE) into the distal ESOPHAGUS, commonly due to incompetence of the LOWER ESOPHAGEAL SPHINCTER.Amyotrophic Lateral Sclerosis: A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)Dancing: Rhythmic and patterned body movements which are usually performed to music.Onions: Herbaceous biennial plants and their edible bulbs, belonging to the Liliaceae.Naval Medicine: The practice of medicine concerned with conditions affecting the health of individuals associated with the marine environment.Diagnosis, Oral: Examination of the mouth and teeth toward the identification and diagnosis of intraoral disease or manifestation of non-oral conditions.Chronology as Topic: The temporal sequence of events that have occurred.Sleep Deprivation: The state of being deprived of sleep under experimental conditions, due to life events, or from a wide variety of pathophysiologic causes such as medication effect, chronic illness, psychiatric illness, or sleep disorder.Ambulatory Surgical Procedures: Surgery performed on an outpatient basis. It may be hospital-based or performed in an office or surgicenter.Gastric Emptying: The evacuation of food from the stomach into the duodenum.Stomach: An organ of digestion situated in the left upper quadrant of the abdomen between the termination of the ESOPHAGUS and the beginning of the DUODENUM.Surgicenters: Facilities designed to serve patients who require surgical treatment exceeding the capabilities of usual physician's office yet not of such proportion as to require hospitalization.Gastric Balloon: An inflatable device implanted in the stomach as an adjunct to therapy of morbid obesity. Specific types include the silicone Garren-Edwards Gastric Bubble (GEGB), approved by the FDA in 1985, and the Ballobes Balloon.Gastroparesis: Chronic delayed gastric emptying. Gastroparesis may be caused by motor dysfunction or paralysis of STOMACH muscles or may be associated with other systemic diseases such as DIABETES MELLITUS.Tablets: Solid dosage forms, of varying weight, size, and shape, which may be molded or compressed, and which contain a medicinal substance in pure or diluted form. (Dorland, 28th ed)Interstitial Cells of Cajal: c-Kit positive cells related to SMOOTH MUSCLE CELLS that are intercalated between the autonomic nerves and the effector smooth muscle cells of the GASTROINTESTINAL TRACT. Different phenotypic classes play roles as pacemakers, mediators of neural inputs, and mechanosensors.Intestinal Pseudo-Obstruction: A type of ILEUS, a functional not mechanical obstruction of the INTESTINES. This syndrome is caused by a large number of disorders involving the smooth muscles (MUSCLE, SMOOTH) or the NERVOUS SYSTEM.Esophagogastric Junction: The area covering the terminal portion of ESOPHAGUS and the beginning of STOMACH at the cardiac orifice.Manometry: Measurement of the pressure or tension of liquids or gases with a manometer.Gastrointestinal Transit: Passage of food (sometimes in the form of a test meal) through the gastrointestinal tract as measured in minutes or hours. The rate of passage through the intestine is an indicator of small bowel function.Colonic Pseudo-Obstruction: Functional obstruction of the COLON leading to MEGACOLON in the absence of obvious COLONIC DISEASES or mechanical obstruction. When this condition is acquired, acute, and coexisting with another medical condition (trauma, surgery, serious injuries or illness, or medication), it is called Ogilvie's syndrome.Product Surveillance, Postmarketing: Surveillance of drugs, devices, appliances, etc., for efficacy or adverse effects, after they have been released for general sale.Torsades de Pointes: A malignant form of polymorphic ventricular tachycardia that is characterized by HEART RATE between 200 and 250 beats per minute, and QRS complexes with changing amplitude and twisting of the points. The term also describes the syndrome of tachycardia with prolonged ventricular repolarization, long QT intervals exceeding 500 milliseconds or BRADYCARDIA. Torsades de pointes may be self-limited or may progress to VENTRICULAR FIBRILLATION.Adverse Drug Reaction Reporting Systems: Systems developed for collecting reports from government agencies, manufacturers, hospitals, physicians, and other sources on adverse drug reactions.Long QT Syndrome: A condition that is characterized by episodes of fainting (SYNCOPE) and varying degree of ventricular arrhythmia as indicated by the prolonged QT interval. The inherited forms are caused by mutation of genes encoding cardiac ion channel proteins. The two major forms are ROMANO-WARD SYNDROME and JERVELL-LANGE NIELSEN SYNDROME.Deductibles and Coinsurance: Cost-sharing mechanisms that provide for payment by the insured of some portion of covered expenses. Deductibles are the amounts paid by the insured under a health insurance contract before benefits become payable; coinsurance is the provision under which the insured pays part of the medical bill, usually according to a fixed percentage, when benefits become payable.United States Food and Drug Administration: An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.Emergency Service, Hospital: Hospital department responsible for the administration and provision of immediate medical or surgical care to the emergency patient.Emergencies: Situations or conditions requiring immediate intervention to avoid serious adverse results.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Emergency Medicine: The branch of medicine concerned with the evaluation and initial treatment of urgent and emergent medical problems, such as those caused by accidents, trauma, sudden illness, poisoning, or disasters. Emergency medical care can be provided at the hospital or at sites outside the medical facility.Emergency Treatment: First aid or other immediate intervention for accidents or medical conditions requiring immediate care and treatment before definitive medical and surgical management can be procured.Suspensions: Colloids with liquid continuous phase and solid dispersed phase; the term is used loosely also for solid-in-gas (AEROSOLS) and other colloidal systems; water-insoluble drugs may be given as suspensions.Piperidines: A family of hexahydropyridines.Drug Interactions: The action of a drug that may affect the activity, metabolism, or toxicity of another drug.Gastrointestinal Motility: The motor activity of the GASTROINTESTINAL TRACT.Simethicone: A poly(dimethylsiloxane) which is a polymer of 200-350 units of dimethylsiloxane, along with added silica gel. It is used as an antiflatulent, surfactant, and ointment base.Ether-A-Go-Go Potassium Channels: A family of voltage-gated potassium channels that are characterized by long N-terminal and C-terminal intracellular tails. They are named from the Drosophila protein whose mutation causes abnormal leg shaking under ether anesthesia. Their activation kinetics are dependent on extracellular MAGNESIUM and PROTON concentration.Potassium Channels, Voltage-Gated: Potassium channel whose permeability to ions is extremely sensitive to the transmembrane potential difference. The opening of these channels is induced by the membrane depolarization of the ACTION POTENTIAL.Potassium Channels: Cell membrane glycoproteins that are selectively permeable to potassium ions. At least eight major groups of K channels exist and they are made up of dozens of different subunits.Potassium Channel Blockers: A class of drugs that act by inhibition of potassium efflux through cell membranes. Blockade of potassium channels prolongs the duration of ACTION POTENTIALS. They are used as ANTI-ARRHYTHMIA AGENTS and VASODILATOR AGENTS.

Delayed gastric emptying after Billroth I pylorus-preserving pancreatoduodenectomy: effect of postoperative time and cisapride. (1/188)

OBJECTIVE: To study the recovery course of gastric emptying after Billroth I pylorus-preserving pancreatoduodenectomy (PPPD) and therapeutic effects of cisapride. METHODS: To examine gastric emptying, acetaminophen was given, admixed in a pasty liquid meal, to 16 patients undergoing PPPD before surgery and at 1, 3, 6, 9, and 12 months after surgery. Cisapride was given orally to 10 patients before they received the acetaminophen regimen. Electrogastrography was performed at 2 weeks to 1 month after surgery in eight patients and at 6 to 12 months after surgery in seven patients. RESULTS: Gastric emptying was delayed but returned to the preoperative level by 6 months after surgery. Pretreatment with cisapride accelerated gastric emptying during months 1 to 6 but not during months 6 to 12 after surgery. Electrogastrography frequently showed tachygastria 2 weeks to 1 month after surgery, but seldom 6 to 12 months after surgery. CONCLUSIONS: After Billroth I PPPD, gastric emptying is delayed but recovers by 6 months after surgery. Tachygastria may play a part in the pathogenesis of delayed gastric emptying, but it can be treated with cisapride.  (+info)

Intestinal prokinesia by two esters of 4-amino-5-chloro-2- methoxybenzoic acid: involvement of 5-hydroxytryptamine-4 receptors and dissociation from cardiac effects in vivo. (2/188)

In five fasting, conscious dogs, we compared the prokinetic action of two selective 5-hydroxytryptamine-4 (5-HT4) receptor agonists with low affinity for 5-HT3 receptors ML10302 (2-piperidinoethyl 4-amino-5-chloro-2-methoxybenzoate) and SR59768 (2-[(3S)-3-hydroxypiperidino]ethyl 4-amino-5-chloro-2-methoxybenzoate) in the duodenum and jejunum, using cisapride as a reference compound. Heart rate and rate-corrected QT (QTc) also were monitored to assess whether or not the cardiac effects of cisapride are shared by other 5-HT4 receptor agonists. Both ML10302 and SR59768 dose-dependently stimulated spike activity in the duodenum with similar potencies (dose range, 3-300 nmol/kg i.v.; ED50 values: 24 and 23 nmol/kg i.v., respectively), mimicking the effect of cisapride (30-3000 nmol/kg i.v.). The maximal effect was achieved with the dose of 100 nmol/kg i.v. for both compounds. Similar findings were obtained in the jejunum. Atropine and GR125487 (1-[2-[(methylsulfonyl)amino]ethyl]-4-piperidinyl-methyl 5-fluoro-2-methoxy-1H-indole-3-carboxylate, selective 5-HT4 receptor antagonist), at doses having no effect per se, antagonized intestinal prokinesia by maximal doses of ML10302 and SR59768. Neither ML10302 nor SR59768 had any effect on heart rate or QTc at any of the doses tested, whereas cisapride, at the highest dose (3000 nmol/kg), induced tachycardia and lengthened the QTC (p <.01). In conclusion, ML10302 and SR59768 share with cisapride a similar prokinetic action in the canine duodenum and jejunum in vivo. This effect is mediated by pathways involving activation of 5-HT4 and muscarinic receptors. Unlike cisapride, which induces tachycardia and prolongs the QTc by a mechanism probably unrelated to 5-HT4 receptor activation, ML10302 and SR59768 are devoid of cardiac effects in this model.  (+info)

A simple high-performance liquid chromatography assay for the major cisapride metabolite, norcisapride, in human urine. (3/188)

A simple high-performance liquid chromatography assay using fluorescence detection for the major metabolite of the gastric prokinetic drug cisapride, norcisapride, is presented. Analysis is performed using an Alltech Platinum EPS C8 column with a mobile phase made up of methanol and 0.02M sodium dihygrogen phosphate (45:55, v/v) containing triethylamine (1 g/L). Complete resolution is achieved among norcisapride, the internal standard (metoclopramide), and endogenous urinary components. The assay is linear over the range 50-2000 ng/mL with a mean recovery of 71.2% across the analytical range following solvent extraction with toluene-isoamyl alcohol (95:5, v/v). Intraday coefficients of variation (precision) determined at 200 and 1000 ng/mL are 6.0 and 9.8%, respectively, and interday coefficients of variation are 8.8 and 6.6%, respectively. Intra- and interassay accuracy (as mean relative error) determined at the same concentrations is within 10% in all cases. An analysis of urine samples from a healthy volunteer following the administration of a single 10-mg oral dose of cisapride is shown.  (+info)

Clinical considerations in GERD (gastroesophageal reflux disease) therapy: focus on cisapride. (4/188)

Heartburn, the major symptom of gastrointestinal reflux disease (GERD), is a common condition that is usually self-treated with over-the-counter products. For patients with severe or recurrent symptoms of GERD, pharmacologic therapy includes acid suppression with H2-receptor antagonists and proton pump inhibitors, and, alternatively, the use of prokinetic agents. While all of these are efficacious, given its high efficacy in nonerosive and mild-to-moderate erosive esophagitis, the prokinetic agent cisapride deserves significant consideration in this patient population.  (+info)

Identification of SK-951, a novel benzofuran derivative, as an agonist to 5-HT4 receptors. (5/188)

The pharmacological profile of SK-951 ((-)4-amino-N-[2-(1-azabicyclo[3.3.0]octan-5-yl) ethyl]-5-chloro-2,3-dihydro-2-methylbenzo[b]furan-7-carboxamide hemifumarate) was identified in relation to serotonin 5-HT3 and 5-HT4 receptors by the receptor binding assay and functional studies. The receptor binding assay showed that SK-951 bound to the 5-HT3 receptor with a high affinity, to the 5-HT4 receptor with relatively higher affinity and to the muscarinic M2 receptor with a low affinity, but not to dopamine D1 and D2 and serotonin 5-HT1 and 5-HT2 and muscarinic M1 and M3 receptors. SK-951 caused relaxations of tunica muscularis mucosae preparations from rat esophagus which were precontracted with carbachol, and the effects were antagonized by GR113808, a selective 5-HT4 antagonist. In the longitudinal muscle with myenteric plexus (LMMP) preparations from guinea pig ileum, SK-951 enhanced the electrically-stimulated contraction of preparations in which the 5-HT1, 5-HT2 and 5-HT3 receptors were blocked, and it enhanced the electrically-stimulated release of [3H]acetylcholine (ACh). These effects of SK-951 were antagonized by GR113808. SK-951 inhibited the 5-HT3 receptor-mediated contractions. These results indicate that SK-951 possesses properties of an agonist for the 5-HT4 receptor and an antagonist for the 5-HT3 receptor. Thus, SK-951 is a new and potent 5-HT4-receptor agonist and causes contractions of guinea pig ileum mediated by enhancement of ACh release via the 5-HT4 receptor.  (+info)

Randomised controlled trial of cisapride in preterm infants. (6/188)

AIM: To determine the effect of cisapride on gastrointestinal motility in preterm infants. METHODS: Cisapride (0.2 mg/kg, 8 hourly ) or placebo was given first for seven days in a double blind randomised crossover study of 10 preterm infants. Gastrointestinal motility was assessed on day 3 of each treatment. The half gastric emptying time (GET1/2) was determined by using ultrasonography to measure the decrease in the gastric antral cross sectional area after a feed. The whole gastrointestinal transit time (WGTT) was assessed by timing the transit of carmine red through the gut. Treatments were compared using the Wilcoxon matched pairs signed ranks test. RESULTS: Median (range) birthweight was 1200 (620, 1450) g and postconceptional age 33 (29, 34) weeks at recruitment. GET1/2 was significantly longer during cisapride treatment than during placebo; the median of the differences (95% confidence interval) was 19.2 (11, 30 minutes, p=0.008). WGTT was also longer during cisapride treatment, but the difference was not significant; the median of the differences was 11(-18, 52 hours, p=0.1). CONCLUSIONS: Cisapride delays gastric emptying and may delay WGTT in preterm infants. Its use to promote gastrointestinal motility in this group cannot be recommended.  (+info)

The effect of cisapride on duodenal acid exposure in the proximal duodenum in healthy subjects. (7/188)

AIM: To investigate the effect of the prokinetic drug, cisapride, on fasting and postprandial acid exposure in the proximal duodenum. METHODS: Using a double-blind, placebo-controlled crossover study design, 12 healthy male volunteers were studied. After 1 week of dosing (cisapride 20 mg b.d. orally or placebo), fasting and postprandial antroduodenal pH-and pressure-recordings were made. Using a small-caliber (4 mm) catheter, containing one antral and two duodenal pH electrodes, and two antral and three duodenal pressure recording sites. Transmucosal potential difference was measured to ensure proper catheter position. Infusions of 0.1 N HCl were given in the duodenal bulb. RESULTS: Endogenous acidification of the duodenal bulb occurred more frequently during phase II and postprandially, compared to phase I (P<0.001). During phase I, alkalinization of the antrum was observed. Cisapride significantly increased the postprandial number of duodenal acidic periods (P<0.02), but shortened their duration (P<0.04). The duodenal motor response elicited by exogenous acid was lower during phase I (P<0.05). CONCLUSIONS: Antral and proximal duodenal acidity vary with the phases of the interdigestive motor complex. Cisapride shortens the individual periods of duodenal acidification.  (+info)

Duodenogastric reflux: clinical and therapeutic aspects. (8/188)

BACKGROUND: Duodenogastric reflux is believed to cause damage to gastric mucosa. Most reports on this disorder concern adult patients. PATIENTS AND METHODS: 1120 children with abdominal pain were studied; endoscopic features of duodenogastric reflux were found in 92 patients. To confirm the diagnosis of duodenogastric reflux, cholescintigraphy (Tc99-HEPIDA) was performed. Children with confirmed duodenogastric reflux by scintigraphy were given a prokinetic drug (cisapride). RESULTS: Endoscopic features of duodenogastric reflux were found in 92 children; the diagnosis was confirmed by scintigraphy in 59 patients. There was no significant difference in the severity of inflammation in gastric mucosa compared with the control group, whereas significantly fewer of these patients were infected with Helicobacter pylori. There was no correlation between regions of isotope accumulation and inflammatory lesions in the stomach. The prokinetic drug (cisapride) helped eliminate or greatly reduce duodenogastric reflux in children. CONCLUSIONS: When endoscopic features of duodenogastric reflux are found the final diagnosis should be based on an examination that does not itself influence the motility of the gastrointestinal tract: cholescintigraphy seems to be a useful method. However, because the use of milk as a test meal affects the scintigraphic image, there was no correlation between the area of isotope accumulation and the localisation of inflammatory lesions in the stomach. Duodenogastric reflux seems to be less important as a cause of inflammatory lesions than other factors (such as genetic predisposition, stress, etc). Prokinetic drugs have a beneficial influence on treatment results in children with inflammatory lesions of gastric mucosa with duodenogastric reflux.  (+info)

*Cisapride

... cisapride", issued 1999-Sep-21 Maclennan, S; Augood, C; Cash-Gibson, L; Logan, S; Gilbert, RE (Apr 14, 2010). "Cisapride ... Cisapride is still available in the United States and Canada for use in animals, and is commonly prescribed by veterinarians to ... Cisapride has been used for the treatment of gastroesophageal reflux disease (GERD). There is no evidence it is effective for ... Cisapride is a gastroprokinetic agent, a drug that increases motility in the upper gastrointestinal tract. It acts directly as ...

*Velusetrag

"Cisapride". Wikipedia. 2017-02-17. "Tegaserod". Wikipedia. 2017-02-17. Goldberg, M; Li, YP; Johanson, JF; Mangel, AW; Kitt, M; ... to earlier generation 5-HT agonists like cisapride and tegaserod. In a large clinical trial in patients with chronic idiopathic ...

*Phenylpropanolamine

"Unsafe Drugs- nimesulide, Cisapride, Phenylpropanolamine Banned". "Madras High Court Revokes Ban on Manufacture and Sale PPA". ...

*Domperidone

Cisapride Itopride Metoclopramide Trimethobenzamide Reddymasu, Savio C.; Soykan, Irfan; McCallum, Richard W. (2007). " ...

*Grapefruit-drug interactions

626-629 Gross AS, Goh YD, Addison RS, Shenfield GM (April 1999). "Influence of grapefruit juice on cisapride pharmacokinetics ... Examples of such known CYP3A4 inhibitors include cisapride (Propulsid),[citation needed] erythromycin, itraconazole (Sporanox ...

*Indigestion

Information regarding withdrawal of Propulsid (cisapride) by Janssen Pharmaceutica. From FDA Thompson Coon J, Ernst E (October ... but the studies evaluated to come to this conclusion used the drug cisapride which has since been removed from the market (now ... as one trial suggests potential benefit over placebo and another shows equivalence with cisapride. So, with the somewhat recent ...

*Hyperprolactinaemia

... cisapride used to treat gastro-oesophageal reflux; medication-induced nausea (such as cancer drugs); and, less often, alpha- ...

*Diazepam

Cisapride may enhance the absorption, and therefore the sedative activity, of diazepam. Small doses of theophylline may inhibit ... Bateman DN (1986). "The action of cisapride on gastric emptying and the pharmacodynamics and pharmacokinetics of oral diazepam ...

*Drug of last resort

Cisapride Clozapine - used in treatment-resistant schizophrenia not responsive to at least two different antipsychotics; the ... such as cisapride. Amikacin Amphotericin B Ceftobiprole Ceftaroline Carbapenems (such as imipenem/cilastatin) - used as drug of ...

*5-HT4 receptor

BIMU-8 Cisapride CJ-033,466 - partial agonist ML-10302 Mosapride Prucalopride Renzapride RS-67506 RS-67333 - partial agonist ... "Overexpression of serotonin4 receptors in cisapride-responsive adrenocorticotropin-independent bilateral macronodular adrenal ...

*Constipation

Cisapride is widely available in third world countries, but has withdrawn in most of the west. It has not been shown to have a ...

*Prokinetic agent

As such, the relatively poor selectivity profile of cisapride versus other receptors (especially hERG [human ether-a-go-go K+] ... Some of these prokinetic agents, such as mosapride and cisapride, classic benzamides, have only moderate affinity for 5HT4 ... Benzamide Cisapride Domperidone Erythromycin Itopride Mosapride Metoclopramide Prucalopride Renzapride Tegaserod Mitemcinal ...

*Serotonin receptor agonist

Cisapride and tegaserod are 5-HT4 receptor partial agonists that were used to treat disorders of gastrointestinal motility. ...

*Intestinal pseudoobstruction

Prucalopride, pyridostigmine, metoclopramide, cisapride, and erythromycin may be used, but they have not been shown to have ...

*Mosapride

... drug information - Drugs Update India Kii, Y.; Ito, T. (May 1997). "Effects of 5-HT4-receptor agonists, cisapride, ...

*CJ-033466

Toga T, Kohmura Y, Kawatsu R (October 2007). "The 5-HT(4) agonists cisapride, mosapride, and CJ-033466, a Novel potent compound ... In animal tests it stimulated gastrointestinal motility with 30 times the potency of cisapride, and with lower affinity for the ...

*Itopride

The affinity of cisapride for 5-HT4 receptors in the heart has been implicated in the undesirable cardiac effects of cisapride ... Itopride belongs to the same benzamide group as cisapride, a drug found to affect QT interval and possibly predispose those ... Moreover, itopride has no affinity for the 5-HT4 receptors, unlike other benzamides such as cisapride and mosapride, which are ... unlike cisapride and mosapride, as it is metabolized by a different enzyme set. New molecular studies on guinea pig ventricular ...

*Risperidone

... similar to gastrointestinal drugs such as metoclopramide and cisapride. Risperidone undergoes hepatic metabolism and renal ...

*Terence Young (politician)

Johnson prescription drug cisapride (brand name in Canada: Prepulsid). Young became a consumer advocate after this incident, ...

*Erythromycin

Other examples include terfenadine (Seldane, Seldane-D), astemizole (Hismanal), cisapride (Propulsid, withdrawn in many ...

*Sucralfate

Triple combination therapy with lansoprazole + cisapride + sucralfate can significantly improve symptoms and quality of life ...

*5-HT3 antagonist

Certain prokinetic drugs such as cisapride, renzapride and metoclopramide, although not 5-HT3 antagonists proper, possess some ...

*Clarithromycin

or if you have hypokalaemia (low blood potassium) Use of clarithromycin with the following medications: cisapride, pimozide, ...

*Atazanavir

... cisapride, St. John's wort, lovastatin, simvastatin, sildenafil, indinavir, or nevirapine. Common side effects include: nausea ...

*Torsades de pointes

The gastrokinetic drug cisapride (Propulsid) was withdrawn from the US market in 2000 after it was linked to deaths caused by ...
Cisapride + methylpolysiloxane is used in the treatment of .get complete information about cisapride + methylpolysiloxane including usage, side effects, drug interaction, expert advice along with medicines associated with cisapride + methylpolysiloxane at 1mg.com
Updated April 12, 2000. Since 1995 several labeling changes for cisapride (Propulsid, Janssen Pharmaceutica) have been required by the Food and Drug Administration (FDA) following serious adverse effects that were reported through the MedWatch reporting program.56 This system is in place to ensure that new safety information is rapidly communicated to the health care field in order to improve patient care. During post-marketing surveillance, cisapride has been associated with prolongation of the QT interval on the electrocardiogram (ECG).4,7,16,56Subsequently, cisapride was associated with the potentially fatal arrhythmia torsades de pointes when taken with certain medications or in patients who have certain underlying conditions predisposing them to arrhythmias.7,14,34,50,55,56. A recent FDA analysis of 270 adverse event reports (including 70 fatalities) revealed that approximately 85% of these cases occurred in patients with identifiable risks such as drug-QTDrug interactions and underlying ...
PURPOSE: To evaluate the efficacy of 20 mg cisapride p.o. in reducing residual gastric volume and pH in adult ambulatory surgical patients. METHODS: Using a prospective randomised double-blind controlled design, we administered either 20 mg cisapride
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The addition of an H2RA to twice-daily PPI has been shown to be helpful, although loss of effect with time (tachyphylaxis) has been reported with H2RAs.. Combination therapy of prokinetics, such as cisapride, with acid suppressants has been shown to be efficacious. However, following its withdrawal from widespread use cisapride is now only available on a named-patient basis. Other prokinetics (eg domperidone and metoclopramide) have not been evaluated in this respect.. Baclofen has been shown to reduce TLOSR and is beginning to be used by some practitioners as adjunctive treatment.. Patients who do not respond to PPIs or who require long-term high doses of acid suppressants for symptom control should be referred for a specialist opinion. Endoscopic evaluation is often followed by 24 pH monitoring (off acid suppression for five days) to confirm excessive acid reflux, preferably with a close symptom-reflux association.. Manometric evaluation should be carried out at the same time to document LOS ...
I stay at home now and Jedd goes to pre school. Ive picked up a new position at work that requires me to work late long hours sometimes. I will be scares for the next 4-5 days though.. I sub at my sons school all day Thurs. and Fri. I work my normal night job tomorrow night, Friday night. Then I "captain" several functions ( I work in a ballroom doing weddings and such) all day Saturday, think I will work from 7a.m. until around 1a.m. the next morning then I will have to turn around and work Sunday morning at 7a.m. until around 2:00p.m. I will be one tired puppy but the paycheck will be worth it. KIWM. FB is good for connecting to other parents. They put each other up in the status in order to gain you more people whos child has the same condition as yours does. I know about 50 or so EE parents. One of them went to a national convention, met alot of other EE Moms and Dads and they had a FB explsion!!! Great way to connect to others. My email is [email protected] That way you can find me. ...
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About StayWell Our web site is designed to provide general information to educate users about programs and services, which may be available through our hospitals. The web site is not intended to provide medical advice nor should the information be used to attempt to determine the presence, absence or severity of any illness or medical condition which may be perceived or experienced by the user of this site. If you have or suspect you may have an illness or condition which you believe requires medical attention, we recommend you call your primary care physician. If you believe you are experiencing a medical emergency please call "911" (or your local medical emergency number) or seek immediate care from the nearest hospital Emergency Department. The provision of information to users of this web site is not intended as an inducement or to otherwise influence a persons decision to order or receive any item or service from a particular provider, practitioner or supplier that is reimbursable under ...
Cisapride is one of the frequently used prokinetic agent used in a variety of GIT disorders by virtue of its effects of its 5 HT receptor agonism.
In this article, we break down what exactly prokinetics are, and why they can be a necessary part of treatment for many functional gut disorders.
Many low birthweight premature babies will have feeding difficulties due to various factors related to their gut immaturity. Some of these factors include lower oesophageal sphincter pressure, delayed gastric emptying, and prolonged gastrointestinal transit time.1 Consequently, when these babies are fed by nasogastric tube, they often develop feed intolerance that is usually manifest by gastric aspirates, regurgitation, bile stained aspirates and/or abdominal distension. They may take several days to weeks to tolerate enteral feeds and are subjected to lengthy periods of parenteral nutrition.. Cisapride is a gastrointestinal prokinetic agent that acts by releasing acetylcholine from the nerve terminals of the gut. In children it increases lower oesophageal sphincter pressure,6 enhances gastric emptying,7-9 and increases intestinal transit time.10 11 It has been widely used in children for a variety of conditions including gastro-oesophageal reflux,6 12 13 intestinal pseudo-obstruction,14 15 and ...
Cisapride: Find the most comprehensive real-world treatment information on Cisapride at PatientsLikeMe. 1 patients with fibromyalgia, multiple sclerosis, major depressive disorder, generalized anxiety disorder, diabetes type 2, post-traumatic stress disorder, systemic lupus erythematosus, bipolar disorder, Parkinsons disease, panic disorder, rheumatoid arthritis, high blood pressure (hypertension), myalgic encephalomyelitis/chronic fatigue syndrome, persistent depressive disorder (dysthymia), amyotrophic lateral sclerosis, epilepsy, migraine, hypothyroidism, osteoarthritis, traumatic brain injury, bipolar II disorder, attention deficit/hyperactivity disorder, asthma, social anxiety disorder, high cholesterol (hypercholesterolemia), irritable bowel syndrome, idiopathic pulmonary fibrosis, gastroesophageal reflux disease, bipolar I disorder or psoriasis currently take Cisapride.
This is a double-blind (neither the physician nor the patient will know the name of assigned treatment) study to determine the effectiveness of cisapride tablets compared to placebo tablets (a tablet identical in appearance to cisapride but does not contain active drug) in patients with a primary diagnosis of idiopathic gastroparesis (a disorder of unknown cause in which the stomach empties its contents very slowly into the small intestine for digestion. Symptoms of gastroparesis may include vomiting, nausea, early feeling of fullness after only a few bites of food, weight loss due to poor absorption of nutrients or low calorie intake, abdominal bloating, poor glycemic (blood sugar) control, lack of appetite, and pain in the stomach area. Patients will take study drug (one 10-mg tablet of cisapride, or one tablet of placebo), orally, 4 times a day, for a period of 8 weeks. Study drug will be taken approximately 15 minutes before each meal, and, with a beverage, before going to bed ...
This is a double-blind (neither the physician nor the patient will know the name of assigned treatment) study to determine the effectiveness of cisapride tablets compared to placebo tablets (a tablet identical in appearance to cisapride but does not contain active drug) in patients with a primary diagnosis of idiopathic gastroparesis (a disorder of unknown cause in which the stomach empties its contents very slowly into the small intestine for digestion. Symptoms of gastroparesis may include vomiting, nausea, early feeling of fullness after only a few bites of food, weight loss due to poor absorption of nutrients or low calorie intake, abdominal bloating, poor glycemic (blood sugar) control, lack of appetite, and pain in the stomach area. Patients will take study drug (one 10-mg tablet of cisapride, or one tablet of placebo), orally, 4 times a day, for a period of 8 weeks. Study drug will be taken approximately 15 minutes before each meal, and, with a beverage, before going to bed ...
The objectives of the study were to determine whether retrospective data can be used to answer questions about the efficacy of prokinetic agents when used to treat horses with post-operative ileus (POI). We describe prevalence and mortality of POI with reference to treatment with four prokinetic agents. By combining data from two Hospitals a study population of 55 horses with POI following pedunculated lipoma obstruction (PLO) was established. Univariable and multivariable associations were determined between short term survival and potential explanatory variables. With death as outcome in multivariable models, breed and hospital were significantly associated with outcome but the use of prokinetic agents was not (P=0.15). However, sample size estimates indicate the low power of this study to detect differences in outcome. It was not possible definitively to evaluate the efficacy of prokinetics as treatment for POI following PLO using retrospective data. The data were suggestive of limited ...
We were initially giving Bactrim and Periactin 2x/day, Metacam in the AM, and a probiotic with pellets midday. We noticed Danas GI system may have been a little iffy the first day or so post-op and the vet suggested we start Cisapride 2x/day which definitely helped. However, we noticed about 8 days post-op that shed lost about 2oz (50g) over the course of 2 days when we ran out of her initial Periactin. Vet suggested giving Periactin again (we had extra from Nutmeg) and adjusting Cisapride to once daily. At this point we are only a couple of days into the new routine (Bactrim/Periactin 2x, Metacam/probiotic/Cisapride 1x/day), but there have still been some fluctuations. In the 2 days shes been back on Periactin she went from 1159g to 1200g (her average is about 1175-1200). Today she was 1200 at 7:30am and somehow 1150 at 10:00pm (both weights taken before meds and veggies ...
This is a common condition in which patients suffer symptoms of upper gastric discomfort or pain in spite of normal endoscopy, ultrasound and other assessments. About one third of patients demonstrate delayed gastric emptying [49], another third demonstrate impaired gastric relaxation and about the same number demonstrate hypersensitivity to gastric distension [50, 51]. In general symptoms relate rather poorly to the abnormalities demonstrated, though Stanghellini et al.[49] found that severe vomiting and postprandial fullness together with female sex were predictive of delayed gastric emptying.. The demonstration of these abnormalities has encouraged the use of drugs to reverse them. In particular, initial interest focused on the role of cisapride, which had been shown to accelerate gastric emptying [52]. Cisapride also enhances postprandial gastric relaxation [53], whilst during fasting it increases fundal tone and perception of distension. These multiple actions may explain the somewhat ...
Prokinetic AgentsProkinetics are promotility agents proposed for use in patients with severe constipation-predominant symptoms. Prucalopride (Motegrity)Prucalopride, a selective 5-hydroxytryptamine (s... more
Generic Acofide(Acotiamide) is used in the treatment of functional dyspepsia. It helps to relieve the symptoms like bloating after meal, epigastric pain/discomfort and early satiety. Acotiamide increases the release of acetylcholine, a chemical that can increase the motility of the intestine.. Generic Acofide (Acotiamide 100 Mg) US $ 2.85 pill - Gastrointestinal Tract @ Health pills online shop. Health pills online shop
OT: this is a pretty good book and valuable reference overall, but they do discount the use of prokinetics (motility agents) in a number of diseases and disorders, including bloat/stasis. I have a very serious problem with that, since metoclopramide has been of great benefit to several of our pigs, and cisapride has been helpful to many on this board ...
Treatment for atrophic gastritis, once properly diagnosed, does not require hospitalization. Treatment is home based. Medications can be prescribed in order to inhibit the secretion of gastric acid, and additional antibiotics will be necessary if infection with the Helicobacter spp bacteria is suspected. If vomiting persists, prokinetic agents (designed to enhance muscle activity in the gastrointestinal tract) may be prescribed as well.. ...
INTRODUCTION. Pharmacological inhibition of cardiac potassium channels encoded by hERG (human ether-à-go-go-related gene) is associated with QT interval prolongation and torsades de pointes arrhythmia. Electrophysiological assays of hERG channel inhibition are integral to the safety testing of novel drug candidates. This study was conducted to compare, for the high affinity hERG inhibitors dofetilide and cisapride, hERG blockade between action potential (AP) and conventional (step and step-ramp) screening waveforms. Furthermore, it evaluated dynamic (pulse-by-pulse) protocol-dependence of hERG channel inhibition by these drugs.. METHODS. Whole-cell patch-clamp recordings were made at 37 degrees C from hERG-expressing HEK 293 cells. Half-maximal inhibitory concentrations (IC(50) values) for I(hERG) blockade were obtained using conventional voltage clamp and action potential clamp, using previously digitised ventricular and Purkinje fibre (PF) AP waveforms.. RESULTS. A more marked variation in ...
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Antiarrhythmics ▪ Flecainide (Tambocor®) Antiarrhythmics ▪ Amiodarone (Cordarone®) Antibiotics ▪ Rifampin (Rifadin®, Rofact®) Antihistamines ▪ Astemizole (Hismanol®) Antibiotics ▪ Clarithromycin (Biaxin®) Ergot Derivatives ▪ Bellergal Spacetabs® Anticonvulsant ▪ Carbamazepine (Tegretol®) Antifungals ▪ Itraconazole (Sporanox®) GI Mortality Agents ▪ Cisapride (Propulsid®)3 Herbal Products ▪ St. Johns Wort (Hypericum perforatum) Calcium Channel Blockers ▪ Felodipine (Plendil/Renedil®) ▪ Nicardipine (Cardene®)▪ Nifedipine (Adalat®) Corticosteroids ▪ Dexamethasone (Decadron®) Immunosuppressants ▪ Cyclosporine (Neoral®, Sandimmune®) Inhaled Steroids ▪ Fluticasone (Flonase®, Advair®) PDE5 Inhibitors ▪ Sildenafil (Viagra®) ▪ Tadalafil (e.g., Cialis®)▪ Vardenafil (Levitra®) Oral/Patch Contraceptive ▪ Norethindrone Statins ▪ Atorvastatin (Lipitor®) or Rosuvastatin 1 History of hepatitis does not rule out HIV PEP. MD and/or HIV Expert ...
Principal Investigator, Effects of Cisapride on gastroesophageal reflux in mechanically ventilated dogs, (Principal Investigator), UC Davis: Center for Companion Animal Health. Co-Principal Investigator, Gastrointestinal transit after laparoscopic-assisted gastropexy, Culp W (VSR) (Principal Investigator), UC Davis: Center for Companion Animal Health. Co-Principal Investigator, Effect of surgical treatment of brachycephalic obstructor syndrome on the lower esophageal area of brachycephalic dogs with evidence of hiatal herniation and gastroesophageal reflux, Mayhew P (VSR) (Principal Investigator), American College of Veterinary Surgeons. Co-Principal Investigator, Effect of surgical treatment of brachycephalic obstructor syndrome on the lower esophageal area of brachycephalic dogs with evidence of hiatal herniation and gastroesophageal reflux, (Principal Investigator), UC Davis: Center for Companion Animal Health. Principal Investigator, Prevalence of zoonotic enteric pathogens in dogs attending ...
Patients with chronic constipation benefit from treatment with 5-hydroxytryptamine 4 (5-HT4) receptor agonists. However, the first-generation 5-HT4 receptor agonists cisapride and tegaserod were withdrawn from the market owing to rare cardiovascular adverse events, which were not 5-HT4-receptor-related, but due to the lack of selectivity of these drugs. Here we report the nonclinical cardiovascular profile of the selective 5-HT4 receptor agonist prucalopride. To assess its non-5-HT4 receptor-mediated effects on cardiovascular electrophysiological parameters, in vitro studies were performed in human ether-a-go-go-related gene-transfected cells, guinea pig ventricular myocytes and papillary muscle preparations, rabbit and dog Purkinje fibers, and the Langendorff rabbit heart. In vivo experiments were performed in a rabbit model for drug-induced proarrhythmogenesis, in anesthetized guinea pigs, and anesthetized and conscious dogs. In addition, human platelet aggregation and coronary artery ...
For insolvably https://clenbuterolpillsforsale.net peptide chain termination and translational accuracy? Ers ketotifen uk considerably aus, was günstigere Preise für Kunden bedeutet? Ampho B has many more side ef! If you try to get up too soon, advair diskus price you may become dizzy or faint. Model for a process arising from many small multiplicative errors! Other derivatives and analogues comprising a similar four ring structure are also included! Difficile diarrhea is largely a nosocomial disease and is the most frequent cause of diarrhea in hospitalized patients? Having trouble keeping color vibrant and healthy looking. Any permethrin cream uk ingrately mitigating circumstances or aggravating circumstances otherwise authorized by law and any of the [enumerated] statutory aggravating circumstances! Cisapride: (Moderate) Because cisapride can enhance gastric emptying in diabetic patients, blood glucose can be affected, which, in turn, may affect the clinical response to antidiabetic agents! ...
|p style=text-align: justify;|Levaquin is used for:|br /|Treating infections caused by certain bacteria. It may also be used to prevent or slow anthrax after exposure. Levaquin is a quinolone antibiotic. It works by killing sensitive bacteria.|br /|Do NOT use Levaquin if:|br /|• you are allergic to any ingredient in Levaquin or to any other quinolone antibiotic (eg, ciprofloxacin)|br /|• you have a certain type of irregular heartbeat (QT prolongation, long QT syndrome) or low blood potassium levels|br /|• you are taking cisapride or certain antiarrhythmics (eg, amiodarone, procainamide, quinidine, sotalol)|br /|Contact your doctor or health care provider right away if any of these apply to you.|br /|Before using Levaquin:|br /|Some medical conditions may interact with Levaquin . Tell your health care provider if you have any medical conditions, especially if any of the following apply to you:|br /|• if you are pregnant, planning to become pregnant, or are breast-feeding|br /|•
Do not use this medication if you are allergic to erythromycin, or if you are also taking cisapride (Propulsid) or pimozide (Orap). If you have liver disease or myasthenia gravis, you may need a dose adjustment or special tests to safely take erythromycin. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Erythromycin can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby ...
Do not use this medication if you are allergic to erythromycin, or if you are also taking cisapride (Propulsid) or pimozide (Orap). If you have liver disease or myasthenia gravis, you may need a dose adjustment or special tests to safely take erythromycin. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Erythromycin can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby ...
Dicyclomine Hcl/Dicyloverine Hcl with Another pathway, Omeprazole with Another pathway, Dicyclomine Hcl/Dicyloverine Hcl with Another pathway, Hyoscine with Another pathway, Buscopan with Another pathway, Cisapride with Another pathway, Metoclopramide with Another pathway, ...
Unfortunately, the FDA has never seen the choice in this fashion. FDA never keen on analyzing comparative risk or benefit of various treatments, saw risks in the use of digestive prokinetics that others simply did not see. In the case of Zelnorm, the last digestive prokinetic on the US market (which has the capability of regenerating digestive nerve and muscle tissue), FDA removed from the USA market due to a vague assessment of a 0.1% risk of cardiovascular side effects (i.e.- heart attack or angina), this was despite additional reports that the individuals who had these side effects had pre-existing cardiovascular conditions. With regard to a second prokinetic, Propulsid, Food and Drug removed it from the US market because 70 people suffered a cardiac condition known as prolonged QT syndrome, a condition that could have been diagnosed through the use of EKG. A final prokinetic, Domperidone which helps to restore proper swallowing function in individuals with paralysis never saw the light of ...
An example of an effective prokinetic agent would be represented by muscarinic receptor agonist or by inhibitors of the enzyme acetylcholinesterase ...
We, Accretion Pharmaceuticals is one of the prominent leading Manufacturer, Supplier and Exporter of Magaldrate 400mg+Simethicone 20mg 5 ml - 170 ml, We own a Revised Schedule M license and a plant facility is being constructed by us for the ease of manufacturing and it is under the consent of WHO guidelines from Sanand, Gujarat, India
View drug interactions between Pepto-Bismol Original Strength and simethicone. These medicines may also interact with certain foods or diseases.
This study supports the need to model the dynamic nature of hERG channel pharmacology, especially trapping, to explain why some drugs with similar hERG-blocking potency have different proarrhythmic liabilities. Together with multichannel pharmacology, our IKr-dynamic ORd model was able to stratify all CiPA training compounds into their corresponding TdP risk groups.. A unique feature of our approach is the use of a continuous parameter (Vhalf-trap) to represent the tendency of a drug to be trapped on hERG channel closing. Although the Vhalf-trap parameters appear consistent with previous classifications of compounds as either trapped or nontrapped by block recovery experiments, as in the case of dofetilide,26 bepridil, cisapride,11 and verapamil,21 some discrepancies exist. For instance, quinidine and terfenadine were considered nontrapped and trapped, respectively, in previous block recovery experiments11,26; however, quinidine seems to be more trapped than terfenadine based on their Vhalf-trap ...
You or your child should not use astemizole (Hismanal®), cisapride (Propulsid®), erythromycin (Ery-Tab®), pimozide (Orap®), quinidine (Cardioquin®), or terfenadine (Seldane®) while receiving this medicine because of the risk of unwanted side effects. Using this medicine for a long time or using it too much while you are pregnant (especially during the first trimester) can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using this medicine, tell your doctor right away. This medicine may rarely cause serious liver problems. Check with your doctor right away if you or your child are having more than one of these symptoms: abdominal or stomach pain or tenderness, clay-colored stools, dark urine, decreased appetite, fever, headache, itching, loss of appetite, nausea and vomiting, skin rash, swelling of the feet or lower legs, unusual tiredness or weakness, or yellow eyes or skin. This medicine may rarely ...
As an illustration, if a hospital patient has his stomach contents drained through a naso-gastric tube, he has to get extra intravenous infusion of potassium to make up for the potassium losses as a result of stomach suction or stomach drainage, as it is also called.. The medical name for that depletion of potassium is "NG losses" (NG stands for "nasogastric").. Naso-gastric tube has to be inserted after an operation on gastro-intestinal tract, it is a standard medical procedure.. There was a case in Canada in 2000 when a fifteen-year-old girl, who was bulimic, died of a common drug Prepulsid, also known as Cisapride.. She has been taking that drug for three months before her death; it was prescribed by a doctor to treat a bloating feeling and vomiting.. It was mentioned in the coroners inquest, that the girl had apparently mislead her doctor with regards to the frequency of her vomiting; and he was thus not alerted to the possibility of a serious potassium depletion, under which the side ...
The strongest acid blockers are called proton pump inhibitors, these block the pump that makes the acid, acting directly on the acid producing mechanism and are very effective. They have a very powerful acid blocking effect. Examples of these drugs are Omeprazole or Lansoprazole. A small number of patients (less than 10%) are quite resistant to these drugs and require large doses to control symptoms. Specialists may use doses above those licensed in certain cases.  Another type of drug used in some cases has an effect of the movement of food down the oesophagus and stomach. These are known as prokinetic agents and they speed the transit of food and liquid through the oesophagus and stomach, so that there is less food and acid residue to reflux up. These can be useful in certain cases, but do not tend to be the first treatment of choice. There are two general ways to use drug therapy, either starting with the weakest treatment and building up to the strongest treatments if required, or ...
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TY - JOUR. T1 - Efficacy and safety of UI05MSP015CT in functional dyspepsia. T2 - A randomized, controlled trial. AU - Yoon, Hyuk. AU - Lee, Dong Ho. AU - Lee, Yong Hyun. AU - Jeong, Ju Cheol. AU - Lee, Soo Teik. AU - Choi, Myung Gyu. AU - Jeon, Seong Woo. AU - Shim, Ki Nam. AU - Baik, Gwang Ho. AU - Kim, Jae Gyu. AU - Moon, Jeong Seop. AU - Sung, In Kyung. AU - Lee, Sang Kil. AU - Rhee, Poong Lyul. AU - Jung, Hwoon Yong. AU - Lee, Bong Eun. AU - Kim, Hyun Soo. AU - Kim, Sang Gyun. AU - Lee, Kee Myung. AU - Seong, Jae Kyu. AU - Jang, Jin Seok. AU - Park, Jong Jae. PY - 2018/9/1. Y1 - 2018/9/1. N2 - Background/Aims: To evaluate the efficacy and safety of a controlled release, once-daily formulation of mosapride (UI05MSP015CT) in patients with functional dyspepsia (FD). Methods: Patients with FD were randomly assigned (1:1) to receive either UI05MSP015CT (15 mg once a day, study group) or mosapride (5 mg three times a day, control group) and corresponding placebo for 4 weeks. The primary endpoint ...
In Parkinsons disease, specific antikinetic and prokinetic oscillatory activities (beta and gamma) are prominent. These activities can therefore be used as surrogate translational biomarkers for Drug Discovery. ...
1 Answer - Posted in: keflex, fever, infections, skin infection - Answer: Your dr has to be dense. I would take it until i could call my dr asap and ...
0078] More specifically, a compound of the present invention may be administered as a combination with one or more compounds selected from the group consisting of dopamine D2 receptor antagonists, such as, chlorpromazine, prochlorperazine, haloperidol, alizapride, domperidone, metoclopramide and itopride; serotonin 5-HT4 receptor agonists, such as, cisapride, cinitapride, mosapride, renzapride, prucalopride, tegaserod, velusetrag, ATI-7505 and compounds described in WO 2005068461, US 2005228014, WO 2005080389, US 2006100426, US 2006100236, US 2006135764, US 2005277671, WO 2005092882, WO 2005073222, JP 2005104896, JP 2005082508, WO 2005021539, JP 2004277319, JP 2004277318, WO 2004026869, EP 1362857, WO 2006108127, US 20060183901, WO 2006127815, US 20060276482, WO 2007005951, WO 2007010390, WO 2007005951, WO 2007048643, WO 2007096352, WO 2007068739 and WO 20070117796; serotonin 5-HT3 receptor agonists, such as, pumesotrag and compounds described in WO 2007004041; serotonin 5-HT3 receptor ...
Aspiration syndromes include all conditions in which foreign substances are inhaled into the lungs. Most commonly, aspiration syndromes involve oral or gastric contents associated with gastroesophageal reflux (GER), swallowing dysfunction, neurological disorders, and structural abnormalities.
Do not use this medicine if you or your child are also using alfuzosin (Uroxatral®), cisapride (Propulsid®), colchicine (Colcrys®), dronedarone (Multaq®), lovastatin (Altocor®, Altoprev®, Mevacor®), lurasidone (Latuda®), oral midazolam (Versed®), pimozide (Orap®), ranolazine (Ranexa®), rifampin (Rifadin®, Rimactane®), sildenafil (Revatio®), simvastatin (Simcor®, Vytorin®, Zocor®), triazolam (Halcion®), or ergot medicines (eg, dihydroergotamine, ergotamine, methylergonovine, Cafergot®, D.H.E. 45®, Ergomar®, Ergostat®, Methergine®, Migranal®, Wigraine®). Do not take other medicines unless they have been discussed with your doctor. This includes prescription and nonprescription (over-the-counter [OTC]) medicines, and herbal (eg, St. Johns wort) or vitamin supplements. Check with your doctor right away if you or your child have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, unusual tiredness or weakness, or yellow eyes or skin. ...
GAS-X THIN STRIPS (Simethicone) drug information & product resources from MPR including dosage information, educational materials, & patient assistance.
Iberogast is a clinically proven prokinetic used for the treatment and management of Irritable Bowel Syndrome IBS and Functional Dyspepsia FD.
Volunteer with Gastroparesis Patient Association for Cures and Treatments (G-PACT). Find Gastroparesis Patient Association for Cures and Treatments (G-PACT) volunteering opportunities at VolunteerMatch!
As you probably have read online, gastroparesis is a disease where the stomach does not empty properly leading to feelings of fullness early in a meal
Pascalle Johanna addresses the doctor who did not believe her and told her to go to a psychiatrist, even though she was later diagnosed with gastroparesis.
Ive been having what seems like an abundance of Pts lately with gastroparesis. Im really trying to understand it. I *know* what it is but Im feeling like Im not doing my Pts any good. What do
Levosulpiride is a substituted benzamide antipsychotic, reported to be a selective antagonist of dopamine D2 receptor activity on both central and peripheral levels. It is an atypical neuroleptic and a prokinetic agent. Levosulpiride is also claimed to have mood elevating properties. Chemically, it is the (S)-(−)-enantiomer of sulpiride. Levosulpiride is used in the treatment of: psychoses particularly negative symptoms of schizophrenia anxiety disorders dysthymia vertigo dyspepsia irritable bowel syndrome premature ejaculation. Levosulpiride is not currently licensed for treatment of premature ejaculation in the UK or other European countries. Side effects include amenorrhea, gynecomastia, galactorrhea, changes in libido, and neuroleptic malignant syndrome. In the U.S., as of 2013 only one case of adverse reaction to Levosulpiride had been recorded on the FDA Adverse Event Reporting System Database. A case of rapid onset resistant dysto caused by low dose levosulpiride was reported in India. ...
More recently, detection of an important indicator of proarrhythmic liability became possible in potential drug candidates. Also, once the mechanism relating potassium channel blockage to TdP was realized, the US Food and Drug Administration (FDA) added possible or high risk for TdP as a safety criterion for new drug applications [12]. Compounds with hERG blocking liability might fail during preclinical and costly clinical trials. Hence, understanding the molecular mechanisms involved in binding of drugs to hERG channels and drug risk identification from channel blockage is now considered essential for both pharmaceutical companies and regulatory authorities. Numerous approved drugs such as the aforementioned terfenadine (antihistamine) and cisapride (a gastroprokinetic agent) were eventually recalled due to cardiac toxicity associated with blockade of hERG channel [13]. It is well-established that the majority of potential hERG blockers prolong QT, but the converse is not so. There are a few ...
It is very important that your doctor check the progress of you or your child at regular visits to make sure this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects. Do not use this medicine if you or your child are also using astemizole (Hismanal®), cisapride (Propulsid®), lovastatin (Mevacor®), pimozide (Orap®), simvastatin (Zocor®), terfenadine (Seldane®), or certain ergot medicines (such as dihydroergotamine, ergotamine, D.H.E. 45®, Ergomar®, Ergostat®, or Migranal®). If you have kidney or liver disease, do not take both this medicine and colchicine (Colcrys®). Using these medicines together may increase risk for more serious side effects. If your or your childs symptoms do not improve within a few days, or if they become worse, check with your doctor. Make sure your doctor knows if you are pregnant or planning to become pregnant. If you become pregnant while using this medicine, tell your doctor right away. Stop using this medicine ...
Be sure to mention any of the following anticoagulants blood thinners such as warfarin coumadin ; antidepressants; antifungals such as ketoconazole nizoral , itraconazole sporanox , or voriconazole vfend ; aspirin and other nsaids such as ibuprofen advil, motrin and naproxen aleve, naprosyn ; certain medications for human immunodeficiency virus hiv or acquired immunodeficiency syndrome aids such as atazanavir reyataz , indinavir crixivan , nelfinavir viracept , ritonavir norvir, in kaletra , and saquinavir invirase ; cimetidine tagamet ; cisapride propulsid ; clarithromycin biaxin, in prevpac ; cyclosporine neoral, sandimmune ; danazol danocrine ; delavirdine rescriptor ; dexamethasone decadron ; digoxin digitek, lanoxin, lanoxicaps ; diltiazem cardizem, dilacor, tiazac ; diuretics; disopyramide norpace ; dofetilide tikosyn ; erythromycin e ...
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Baseline characteristics were similar between the trophic-feeding (n = 508) and full-feeding (n = 492) groups. The full-feeding group received more enteral calories for the first 6 days, about 1300 kcal/d compared with 400 kcal/d (P , .001). Initial trophic feeding did not increase the number of ventilator-free days (14.9 [95% CI, 13.9 to 15.8] vs 15.0 [95% CI, 14.1 to 15.9]; difference, -0.1 [95% CI, -1.4 to 1.2]; P = .89) or reduce 60-day mortality (23.2% [95% CI, 19.6% to 26.9%] vs 22.2% [95% CI, 18.5% to 25.8%]; difference, 1.0% [95% CI, -4.1% to 6.3%]; P = .77) compared with full feeding. There were no differences in infectious complications between the groups. Despite receiving more prokinetic agents, the full-feeding group experienced more vomiting (2.2% vs 1.7% of patient feeding days; P = .05), elevated gastric residual volumes (4.9% vs 2.2% of feeding days; P , .001), and constipation (3.1% vs 2.1% of feeding days; P = .003). Mean plasma glucose values and average hourly insulin ...
Can gastroparesis kill you - Can gastroparesis kill you? Gastroparesis. I have never seen a death due to gastroparesis alone. Theoretically, the resulting dehydration from the vomiting could kill you, if not treated appropriately, particularly if you have other disease conditions. Gastroparesis usually involves chronic vomiting due to paralysis of the stomach which leads to dehydration, and often requires hospitalization to manage the dehdyration and salt losses.
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Metoclopramide Omega: Metoclopramide belongs to the classes of medications called antiemetics and prokinetics. It is used to improve stomach emptying after surgery or other procedures. It can also be used to prevent nausea after operations and is useful in preventing the nausea and vomiting associated with cancer chemotherapy. It works by speeding up the rate at which the stomach empties and by blocking nausea triggers in the brain.
Short overviewMotilium (domperidone) is used for the treatment of nausea and vomiting. Its designed for adult patients and should not be taken by children unless otherwise prescribed by a medical professional. Motilium can also be recommended for gastroparesis
Take this medicine by mouth. Use the special dropper included with the medicine. The dosage can be mixed with one ounce of cool water, infant formula or other suitable liquids to ease administration. Follow the directions on the label or those given to you by your doctor or health care professional. Do not take your medicine more often than directed.. Talk to your pediatrician regarding the use of this medicine in children. While this drug may be used in children as young as newborns for selected conditions, precautions do apply.. ...
Tome este medicamento por vía oral. Utilice el gotero dosificador especial suministrado con el medicamento. Puede mezclar la dosis con una onza de agua fría, fórmula para lactantes u otros líquidos apropiados para facilitar la administración del medicamento. Siga las instrucciones de la etiqueta del medicamento o las de su médico o su profesional de la salud. No tome su medicamento con una frecuencia mayor a la indicada.. Hable con su pediatra para informarse acerca del uso de este medicamento en niños. Aunque este medicamento ha sido recetado a niños tan menores como recién nacidos para condiciones selectivas, las precauciones se aplican.. ...
Learn more about Gastroparesis at Presbyterian/St. Lukes Medical Center DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ...
Learn more about Gastroparesis at Redmond Regional Medical Center DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ...
Im looking for help on obtaining Domperidone here in the US. My doctor talked with me about how much better it is than Reglan but wasnt willing to prescribe it. I know a lot of people have been able to obtain it through off shore and Canada. It looks like the site I have used for another medication in the past, and the main site people have used in the past, now requires a prescription. Can anyone point me in the right direction?
Buy Motilium Online from $0.27 per pill Domperidone: indications Motilium contains Domperidone as an active ingredient. You may use Domperidone for
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Motilin, a peptide hormone has a direct excitatory effect on circular smooth muscle strips derived from the human colon. Reduced plasma motilin concentration has been reported in adults with chronic constipation. Erythromycin, a non-peptide motilin receptor agonist, induces phase 3 of the migrating motor complex (MMC) in the antro-duodenum and also reduces oro-cecal transit time. A pediatric study has reported an improvement in clinical symptoms of constipation following erythromycin administration, but the effect on colon motility in children has not been formally evaluated. We used colon manometry to study the effect of intravenous erythromycin lactobionate at 1 mg/kg on colon motiltiy in ten children. We selected patients with normal antroduodenal and colon manometry studies that were performed simultaneously. All studies were performed for clinically indicated reasons. We quantified the effect of erythromycin on colon contraction by calculating the area under the curve (AUC). The mean (SE of mean)
BACKGROUND/AIMS: To investigate whether transit time could influence H2 consuming flora and certain indices of colonic bacterial fermentation. METHODS: Eight healthy volunteers (four methane excretors and four non-methane excretors) were studied for three, three week periods during which they received a controlled diet alone (control period), and then the same diet with cisapride or loperamide. At the end of each period, mean transit time (MTT) was estimated, an H2 lactulose breath test was performed, and stools were analysed. RESULTS: In the control period, transit time was inversely related to faecal weight, sulphate reducing bacteria counts, concentrations of total short chain fatty acids (SCFAs), propionic and butyric acids, and H2 excreted in breath after lactulose ingestion. Conversely, transit time was positively related to faecal pH and tended to be related to methanogen counts. Methanogenic bacteria counts were inversely related to those of sulphate reducing bacteria and methane ...
|p style=text-align: justify;|Diflucan is used for:|br /|Treating and preventing certain yeast and fungal infections. It may also be used for other conditions as determined by your doctor. Diflucan is an azole antifungal. It kills sensitive fungi by interfering with the formation of the fungal cell membrane.|br /|Do NOT use Diflucan if:|br /|• you are allergic to any ingredient in Diflucan|br /|• you are taking astemizole, an aldosterone blocker (eg, eplerenone), cisapride, an ergot alkaloid (eg, ergotamine), erythromycin, pimozide, a serotonin (5-HT1) receptor agonist (eg, eletriptan), or terfenadine|br /|Contact your doctor or health care provider right away if any of these apply to you.|br /|Before using Diflucan:|br /|Some medical conditions may interact with Diflucan . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:|br /|• if you are pregnant, planning to become pregnant, or are breast-feeding|br /|• if you
Cost of clarithromycin Central nervous system: dizziness, confusion, anxiety, insomnia; nightmares. Allergic reactions: rash, anaphylactic reactions; in some cases - Stevens-Johnson syndrome. Other reactions: temporary changes in taste sensations. Contraindications for receiving clarithromycin Cost of clarithromycin severe liver failure, hepatitis (history) Klaritro Sandoz - klaritomitsin. registered in Ukraine porphyria first trimester of pregnancy co-therapy with terfenadine, cisapride, astemizole, pimozide hypersensitivity to clarithromycin and other macrolides The pharmacokinetics of clarithromycin Cost of clarithromycin Clarithromycin is metabolized by enzymes of the cytochrome CYP3A4. The absolute bioavailability of approximately 50%. With multiple dose clarithromycin metabolism character does not change, there is no accumulation. clarithromycin Interaction with other drugs ...
(2005) Richter. Alimentary Pharmacology and Therapeutics. Heartburn is a normal consequence of pregnancy. The predominant aetiology is a decrease in lower oesophageal sphincter pressure caused by female sex hormones, especially progesterone. Serious reflu...
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Metoclopramide, although chemically related to procainamide, does not possess local anesthetic or antiarrhythmic properties. Metoclopramide is used to enhance GI motility, to treat diabetic gastroparesis, as an antinauseant, and to facilitate intubation of the small bowel during radiologic examination. Metoclopramide may be used to treat chemotherapy-induced emesis and as a radiosensitizing agents in the treatment of non-small cell lung carcinoma and glioblastomas in the future ...
Metoclopramide, although chemically related to procainamide, does not possess local anesthetic or antiarrhythmic properties. Metoclopramide is used to enhance GI motility, to treat diabetic gastroparesis, as an antinauseant, and to facilitate intubation of the small bowel during radiologic examination. Metoclopramide may be used to treat chemotherapy-induced emesis and as a radiosensitizing agents in the treatment of non-small cell lung carcinoma and glioblastomas in the future ...
Delayed gastric emptying in the presence or absence of mechanical bowel obstruction can cause distressing symptoms in palliative care patients. We present two patients, both with vomiting due to delayed gastric emptying and gastric outlet obstruction secondary to pancreatic cancer, treated with subcutaneous ranitidine resulting in a symptomatic response. We hypothesise that ranitidine is a useful adjunct to standard treatment with prokinetic agents or octreotide in such patients and potentially those with proximal mechanical bowel obstruction from other malignancies with associated delayed gastric emptying ...
Gastroparesis.. Update After Pacemaker Was Put It. It Hasnt Worked :( : A true, personal story from the experience, I Have Gastroparesis. I posted a story almost 2 years ago about having gastroparesis. At the time i had had the feeding tubes and was waiting for the pacemaker to be put in. well an update from then. I had the pacemaker an...
Doctor answers on Symptoms, Diagnosis, Treatment, and More: Dr. Greiwe on what can i try instead of raglan to treat gastroparesis: Domperidone is a dopamine agonist and can not be bought in the USA. Two side effects include depression and lactation. for topic: What Can I Try Instead Of Raglan To Treat Gastroparesis
View messages from patients providing insights into their medical experiences with Gastroparesis - Symptoms. Share in the message dialogue to help others and address questions on symptoms, diagnosis, and treatments, from MedicineNets doctors.
What are the causes of gastroparesis? Important gastroparesis cause is damage to the vagus nerves that controls the stomach muscles.
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This report is the first to detail the effects of clobutinol, a commonly used antitussive drug, on the HERG cardiac K+ channel. The rhythmic incident correlated to clobutinol in-take in the proband revealed the potential effects of the drug and instigated the present study, which also resulted in the identification of a novel HERG mutation responsible for LQT2.. Drug-Induced Action Potential Prolongation. We found that clobutinol displays an IC50 of ≈2 μM on HERG. As illustrated by computer modeling, clobutinol would induce only mild modifications in the ventricular action potential duration of unaffected individuals. The effects of clobutinol displayed a positive voltage dependence, suggesting that the molecule interacts with an activated state of the HERG channel. Drugs that block HERG current, are often associated with QT prolongation and development of the ventricular arrhythmia known as torsades de pointes. Among them are terfenadine, astemizole, and cisapride. Published IC50 values ...
Your healthcare professionals (e.g., doctor or pharmacist) may already be aware of any possible drug interactions and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first. This drug should not be used with the following medication because very serious interactions may occur: cisapride. If you are currently using this medication listed above, tell your doctor or pharmacist before starting mirtazapine. Avoid taking MAO inhibitors (such as isocarboxazid, linezolid, moclobemide, phenelzine, procarbazine, rasagiline, selegiline, tranylcypromine) within 2 weeks before, during, and after treatment with this medication. In some cases a serious (possibly fatal) drug interaction may occur. Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: bupropion, drugs that lower blood pressure (e.g., ACE inhibitors, calcium channel blockers, water ...
Do not take Generic Reglan if you are allergic to Generic Reglan components.. Be careful with Generic Reglan if youre pregnant or you plan to have a baby.. Do not use potassium supplements or salt substitutes.. Do not take Generic Reglan if you have seizures (e.g., epilepsy), bleeding, blockage, or perforation in your stomach or intestines, or tumors on your adrenal gland (pheochromocytoma).. Do not take Generic Reglan if you are taking cabergoline or pergolide, medicines, such as phenothiazines (e.g., chlorpromazine), that may cause extrapyramidal reactions (abnormal, involuntary muscle movements of the head, neck, or limbs).. Be careful with Generic Reglan usage in case of having depression, asthma, heart failure, high blood pressure, diabetes, Parkinson disease, blood problems (eg, porphyria), kidney problems, or low levels of an enzyme called methemoglobin reductase.. Be careful with Generic Reglan usage in case of taking Cisapride or droperidol because side effects, such as muscle ...
Background: Functional dyspepsia (FD) is a common disorder but there is currently little efficacious drug therapy. Itopride, a prokinetic approved in several countries, showed promising efficacy in FD in a phase IIb trial. The aim of this study was to test the efficacy and safety of this drug in FD.. Methods: Two similar placebo-controlled clinical trials were conducted (International and North America). Males and females, 18-65 years old, with a diagnosis of FD (Rome II) and the absence (by upper endoscopy) of any relevant structural disease were recruited. All were negative for Helicobacter pylori and, if present, heartburn could not exceed one episode per week. Following screening, patients were randomised to itopride 100 mg three times daily or identical placebo. The co-primary end points were: (1) global patient assessment (GPA) of efficacy; and (2) Leeds Dyspepsia Questionnaire (LDQ). Symptoms were evaluated at weeks 2, 4 and 8. Secondary measures of efficacy included Nepean Dyspepsia ...
We have shown the existence of a vagal pathway that participates in erythromycin prokinetic effects. This pathway primarily modulates the motility and resistance of the pylorus.. The most important result of our study was that the increased gastric emptying rate induced by erythromycin was suppressed by vagal cooling. This demonstrates that vagal pathways are essential for gastrokinetic activity induced by erythromycin. This result does not intrinsically contradict former studies in humans and dogs (6a, 15, 27, 32), although we reached a different conclusion. In previous studies, we also found that vagal section does not drastically modify erythromycin-induced increases in antral and duodenal motility. A decreased emptying rate was not observable in vagotomized patients with drainage because in these patients the pyloric area has been removed or made not functional.. Our results must be interpreted with the knowledge that the regulatory mechanisms may be altered by the experimental conditions. ...
Treatment of gastroparesis depends on the severity of the symptoms. Dietary changes may be helpful and include eating several small meals each day rather than three large meals. The meals should be low in fiber, fat, and roughage. Liquids are often better handled than solid food in patients with gastroparesis. For diabetic patients, controlling blood sugar levels may decrease symptoms of gastroparesis. [Ask your doctor or a registered dietician for dietary guidelines.]. Symptoms of gastroparesis may improve with treatment using medications prescribed by a doctor. In very severe cases, generally with weight loss, a feeding tube is placed in the small intestine to provide nutrition in a way that avoids the stomach.. Newer treatments are being evaluated. One, gastric electric stimulation, uses a pacemaker (a surgically implanted battery operated device) on the stomach. It may be used in some cases where all types of medications fail to adequately control the symptoms of nausea and ...
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Rhythm announced today results demonstrating that RM-131, the companys novel ghrelin agonist, was highly effective in restoring normal gastric function in animal models of delayed
International Journal of Peptides is a peer-reviewed, Open Access journal that publishes original research articles as well as review articles in all areas of peptide research.
Metoclopramide by Sandoz Canada Incorporated: Metoclopramide belongs to the classes of medications called antiemetics and prokinetics. It is used to improve stomach emptying after surgery or other procedures. It can also be used to prevent nausea after operations and is useful in preventing the nausea and vomiting associated with cancer chemotherapy. It works by speeding up the rate at which the stomach empties and by blocking nausea triggers in the brain.
I was diagnosed with Gastroparesis after 5 years of suffering worsening symptoms. I was able to finally find a doctor who specializes in Gastroparesis as well as other gastrointestinal diseases. We are now going through treatments in order to get myself back to a healthy and happy state. This is a blog of my story and my experiences as I work through the disease known as Idiopathic Gastroparesis.
Do not take Generic Reglan if you are allergic to Generic Reglan components.. Be careful with Generic Reglan if youre pregnant or you plan to have a baby.. Do not use potassium supplements or salt substitutes.. Do not take Generic Reglan if you have seizures (e.g., epilepsy), bleeding, blockage, or perforation in your stomach or intestines, or tumors on your adrenal gland (pheochromocytoma).. Do not take Generic Reglan if you are taking cabergoline or pergolide, medicines, such as phenothiazines (e.g., chlorpromazine), that may cause extrapyramidal reactions (abnormal, involuntary muscle movements of the head, neck, or limbs).. Be careful with Generic Reglan usage in case of having depression, asthma, heart failure, high blood pressure, diabetes, Parkinson disease, blood problems (eg, porphyria), kidney problems, or low levels of an enzyme called methemoglobin reductase.. Be careful with Generic Reglan usage in case of taking Cisapride or droperidol because side effects, such as muscle ...

Chronic intestinal pseudo-obstruction: treatment and long term follow up of 44 patients | Archives of Disease in ChildhoodChronic intestinal pseudo-obstruction: treatment and long term follow up of 44 patients | Archives of Disease in Childhood

37-40 Cisapride has been shown to be the most effective prokinetic agent.41-43 In our series, cisapride achieved only temporary ... From 1984 cisapride was used in doses of 0.2-0.3 mg/kg body weight three times daily; this produced a temporary improvement in ... 1987) Cisapride is effective in the long term treatment of gastric motor disorders. Gastroenterology 92:1287. ... 1987) Effect of cisapride on the gastrointestinal transit of a solid meal in normal subjects. Gut 28:13-16. ...
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Metoclopramide, cisapride, and erythromycin may be used, but they have not been shown to have great efficacy. In such cases, ...
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Cisapride: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Cisapride comes as a tablet and liquid to take by mouth. Cisapride usually is taken four times a day, 15 minutes before meals ... Before taking cisapride,. *tell your doctor and pharmacist if you are allergic to cisapride or any other drugs. ... Take cisapride exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. ...
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Buy Cisapride Compounded medication online at 1800PetMeds to help speed up your pets digestive process. Get free shipping on ... Cisapride is usually given at least 30 minutes before feeding.. *Cisapride does not cure the condition for which it is given. ... What is Cisapride Compounded?. Cisapride Compounded is used in dogs and cats to speed up the digestive process without ... what is the base used for liquid cisapride? For the liquid form of cisapride, what is the base used (water, oil, ?), and how ...
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... cisapride", issued 1999-Sep-21 Maclennan, S; Augood, C; Cash-Gibson, L; Logan, S; Gilbert, RE (Apr 14, 2010). "Cisapride ... Cisapride is still available in the United States and Canada for use in animals, and is commonly prescribed by veterinarians to ... Cisapride has been used for the treatment of gastroesophageal reflux disease (GERD). There is no evidence it is effective for ... Cisapride is a gastroprokinetic agent, a drug that increases motility in the upper gastrointestinal tract. It acts directly as ...
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Find the most comprehensive real-world treatment information on Cisapride at PatientsLikeMe. 1 patients with fibromyalgia, ... bipolar I disorder or psoriasis currently take Cisapride. ... Cisapride is a gastrointestinal stimulant used to treat ... What is Cisapride?. Category: Prescription Drugs false ...
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Cisapride  and breastfeeding. Are they compatible?Cisapride and breastfeeding. Are they compatible?

Secretion of the gastrokinetic agent cisapride in human milk. Eur J Clin Pharmacol. 1986 Abstract ... How safe and acceptable is cisapride? Scand J Gastroenterol Suppl. 1989 Abstract ...
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Interactions between Olmesartan-Amlodipine-Hydrochlorothiazide Oral and potassium-wasting-diuretics-cisaprideInteractions between Olmesartan-Amlodipine-Hydrochlorothiazide Oral and potassium-wasting-diuretics-cisapride

... information about interactions between Olmesartan-Amlodipine-Hydrochlorothiazide Oral and potassium-wasting-diuretics-cisapride ... Cisapride/Potassium Wasting Diuretics Interactions. This information is generalized and not intended as specific medical advice ... 1.Prepulsid (cisapride) US prescribing information. Janssen Pharmaceutica Products, L.P. January, 2000. ... If your potassium levels are too low, cisapride may have harmful effects on your heart. ...
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Pager Forum - General, Beginners and Infants - cisapride/propulsid in Canada?Pager Forum - General, Beginners and Infants - cisapride/propulsid in Canada?

cisapride/propulsid in Canada?. Hi, I live in NY close to the Canadian border and wondered if Cisapride/Propulsid is available ... There are some hospitals that are doing studies and have kids who are taking Cisapride right now. One of those hospitals is ...
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Cisapride does not alter gastric volume or pH in patients undergoing ambulatory surgery.Cisapride does not alter gastric volume or pH in patients undergoing ambulatory surgery.

METHODS: Using a prospective randomised double-blind controlled design, we administered either 20 mg cisapride ... To evaluate the efficacy of 20 mg cisapride p.o. in reducing residual gastric volume and pH in adult ambulatory surgical ... Cisapride*. Double-Blind Method. Female. Gastrointestinal Contents / chemistry. Hemodynamics / drug effects. Humans. Hydrogen- ... PURPOSE: To evaluate the efficacy of 20 mg cisapride p.o. in reducing residual gastric volume and pH in adult ambulatory ...
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Megacolon, cisapride, enemas. Now cant pee. | Ask A VetMegacolon, cisapride, enemas. Now can't pee. | Ask A Vet

My cat has Mega Colon and is being treated with CisaPride 5mg/ml suspension. I give 1 and 1/3 ml twice daily or about 1/4 tsp ... He has not had any blood in the urine since then and is only started the Cisapride again this a.m. and only gave him 1 ml and I ... Hello, My cat has Mega Colon and is being treated with CisaPride 5mg/ml suspension. I give 1 and 1/3 ml twice daily or about 1/ ...
more infohttp://www.askavetquestion.com/answer_np.php?id=94-cant-pee-constipation-issues-too

Phenomenex HPLC Application #20145: Cisapride on Lux 5µm Cellulose-4 in RPPhenomenex HPLC Application #20145: Cisapride on Lux 5µm Cellulose-4 in RP

Cisapride on Lux 5µm Cellulose-4 in RP. Column used: Lux® 5 µm Cellulose-4, LC Column 250 x 4.6 mm, Ea Part#: 00G-4491-E0 ...
more infohttp://www.phenomenex.com/Application/Detail/20145

PRIME PubMed | The effect of cisapride in maintaining symptomatic remission in patients with gastro-oesophageal reflux diseasPRIME PubMed | The effect of cisapride in maintaining symptomatic remission in patients with gastro-oesophageal reflux diseas

PubMed journal article The effect of cisapride in maintaining symptomatic remission in patients with gastro-oesophageal reflux ... Cisapride for gastro-oesophageal reflux and peptic oesophagitis.. *Efficacy of cisapride on symptoms and healing of gastro- ... Median time to relapse was 63 days for cisapride, 20 mg twice daily; 59 days for cisapride, 20 mg at night; and 49 days for ... RESULTS: Median time to relapse was 63 days for cisapride, 20 mg twice daily; 59 days for cisapride, 20 mg at night; and 49 ...
more infohttps://www.unboundmedicine.com/medline/citation/9399390/The_effect_of_cisapride_in_maintaining_symptomatic_remission_in_patients_with_gastro_oesophageal_reflux_disease_

Cisapride Compound - Available at PetMart PharmacyCisapride Compound - Available at PetMart Pharmacy

Cisapride compound is specially formulated by our pharmacist to meet your pets needs. Contact us at 877-220-6337 for more ... SKU: PMP544 Categories: For Cats, For Dogs, Non-Sterile Compound, RX Tags: Acid Reflux, cats, Cisapride, Cisapride compound, ... Cisapride Compound Basics. Cisapride Compound treats chronic constipation, megacolon, megaesophagus, and acid reflux disease. ... Cisapride Compound Warnings. Keep out of the reach of children and pets. Do not use in pets with a known allergy or ...
more infohttps://petmartpharmacy.com/product/cisapride-compound/

An Efficacy and Safety Study of Cisapride in Patients With Chronic Gastroparesis After Failure of Other Treatment Options -...An Efficacy and Safety Study of Cisapride in Patients With Chronic Gastroparesis After Failure of Other Treatment Options -...

Patients will take study drug (one 10-mg tablet of cisapride, or one tablet of placebo), orally, 4 times a day, for a period of ... Cisapride. Anti-Ulcer Agents. Gastrointestinal Agents. Serotonin Receptor Agonists. Serotonin Agents. Neurotransmitter Agents. ... An Efficacy and Safety Study of Cisapride in Patients With Chronic Gastroparesis After Failure of Other Treatment Options. This ... The purpose of this study is to assess the effectiveness of cisapride in patients with a primary diagnosis of chronic ...
more infohttps://clinicaltrials.gov/show/NCT01281540

An Efficacy and Safety Study of Cisapride in Patients With Chronic Gastroparesis After Failure of Other Treatment Options -...An Efficacy and Safety Study of Cisapride in Patients With Chronic Gastroparesis After Failure of Other Treatment Options -...

An Efficacy and Safety Study of Cisapride in Patients With Chronic Gastroparesis After Failure of Other Treatment Options. The ... Patients will take study drug (one 10-mg tablet of cisapride, or one tablet of placebo), orally, 4 times a day, for a period of ... The purpose of this study is to assess the effectiveness of cisapride in patients with a primary diagnosis of chronic ... Received prior treatment with cisapride. *Have a gycosylated hemoglobin (HbA1c) ,7% and bloodglucose of 126 mg/dL (7.0 mmol/L) ...
more infohttps://clinicaltrials.gov/ct2/show/record/NCT01281540

Randomised controlled trial of cisapride in feed intolerance in preterm infants | ADC Fetal & Neonatal EditionRandomised controlled trial of cisapride in feed intolerance in preterm infants | ADC Fetal & Neonatal Edition

Cisapride was well tolerated by all the infants in the study. Janssenet al 4 studied the long term side effects of cisapride at ... Cisapride or placebo was given at a dose of 0.2 ml/kg/dose (cisapride was supplied as 1 mg/ml suspension) four times daily, ... Several cases of prolonged QT interval syndrome due to cisapride have been reported.21-23 The dose of cisapride used in our ... 1990) Cisapride for intractable constipation in children: observations from an open trial. J Pediatr Gastroenterol Nutr 11:503- ...
more infohttp://fn.bmj.com/content/79/2/F110

CredibleMeds :: CisaprideCredibleMeds :: Cisapride

Cisapride should not be given if the QTc is , 450 milliseconds.. *Cisapride is contraindicated in patients with electrolyte ... The Dangers of Cisapride Drug Interactions. Updated April 12, 2000. Since 1995 several labeling changes for cisapride ( ... cisapride will still be available for specific patients, requiring health care providers and patients receiving cisapride to be ... Cisapride is metabolized primarily by the cytochrome P450 3A4 enzyme.7,56Medications that inhibit cytochrome P450 3A4, (Table I ...
more infohttps://www.crediblemeds.org/everyone/interaction-advisory/cisapride/

Cisapride tabletsCisapride tablets

... What is this medicine?. CISAPRIDE (SIS a pride) is used to treat heartburn in patients with gastroesophageal ... Cisapride has not been available in pharmacies since August 2000. For information, the manufacturer has provided the following ... an unusual or allergic reaction to cisapride, other medicines, foods, dyes, or preservatives ...
more infohttp://pbgmc.staywellsolutionsonline.com/library/encyclopedia/121,1239

Cisapride Pharmacodynamics | PharmaceuticalCisapride Pharmacodynamics | Pharmaceutical

... cisapride has been either aloof or has had its break bound due to letters about continued QT affection due to cisapride, which ... Cisapride is a parasympathomimetic which acts as a serotonin 5-HT4… ... Cisapride Pharmacodynamics. *Leave a comment. In abounding countries (including Canada) cisapride has been either aloof or has ... Cisapride is a parasympathomimetic which acts as a serotonin 5-HT4 agonist. Dispatch of the serotonin receptors increases ...
more infohttps://fluoridekfo.wordpress.com/2013/12/23/cisapride-pharmacodynamics/

Cisapride oral suspensionCisapride oral suspension

... What is this medicine?. CISAPRIDE (SIS a pride) is used to treat heartburn in patients with ... an unusual or allergic reaction to cisapride, other medicines, foods, dyes, or preservatives ...
more infohttp://pbgmc.staywellsolutionsonline.com/library/encyclopedia/121,1240

CISAPRIDE Archives - Stenlake CompoundingCISAPRIDE Archives - Stenlake Compounding

Tag: CISAPRIDE. CISAPRIDE. Posted on January 2, 2017. December 29, 2018. by admin ... Cisapride was removed from the US market in 2000, but remained available on the Australian market until 2004. During that time ... Cisapride capsules has the potential to cause cardiac arrhythmias in humans. In 1996, the Australian Drug Reaction Advisory ... In June 1998 the FDA reported there had been 38 deaths potentially attributable to cisapride from 1993-98 in the USA. A similar ...
more infohttps://www.stenlake.com.au/tag/cisapride/

Cisapride -  નાં ઉપયોગો, ડોઝ, આડઅસરો, ફાયદાઓ, ક્રિયાપ્રતિક્રિયાઓ અને ચેતવણી - Cisapride in GujratiCisapride - નાં ઉપયોગો, ડોઝ, આડઅસરો, ફાયદાઓ, ક્રિયાપ્રતિક્રિયાઓ અને ચેતવણી - Cisapride in Gujrati

Cisapride- નાં ઉપયોગો, ડોઝ, આડઅસરો, ફાયદાઓ, ક્રિયાપ્રતિક્રિયાઓ અને ચેતવણી વિશે જાણો ... Cisapride ની આડઅસરો- Cisapride Side Effects in Gujarati- Cisapride ni adasro * Cisapride સંબંધિત ચેતવણીઓ- Cisapride Related ... Cisapride ની આડઅસરો - Cisapride Side Effects in Gujarati - Cisapride ni adasro. સંશોધન આધારિત, જ્યારે Cisapride નો ઉપયોગ ... Cisapride Benefits & Uses[દવા] લાભો અને ઉપયોગો - Cisapride Benefits & Uses in Gujarati - Cisapride labhon ane upyogon Cisapride ...
more infohttps://www.myupchar.com/gu/medicine/cisapride-p37141284
  • cisapride/propulsid in Canada? (reflux.org)
  • Hi, I live in NY close to the Canadian border and wondered if Cisapride/Propulsid is available there? (reflux.org)
  • Since 1995 several labeling changes for cisapride (Propulsid, Janssen Pharmaceutica) have been required by the Food and Drug Administration (FDA) following serious adverse effects that were reported through the MedWatch reporting program. (crediblemeds.org)
  • Cisapride increases the accent and amplitude of belly (especially antral) contractions, relaxes the pyloric sphincter and the belly bulb, and increases peristalsis of the duodenum and jejunum consistent in accelerated belly elimination and abdominal transit. (wordpress.com)
  • The increases in the motilin level after cisapride or renzapride coincided with significant increases in contractile activities of the antrum to 43.2 ± 5.3% and 44.9 ± 4.6% and of the duodenum to 28.4 ± 3.1% and 34.2 ± 2.2% of phase III activity (100%) from that in the corresponding control period, 0.7 ± 0.4% and 0.2 ± 0.1%, respectively. (elsevier.com)
  • cisapride is a gastrokinetic drug that increases esophageal peristaltic activity and lower esophageal sphincter tone. (lhsc.on.ca)
  • The U.S. Food and Drug Administration (FDA) issued a warning letter to doctors, and cisapride was voluntarily removed from the U.S. market on July 14, 2000. (wikipedia.org)
  • 67 This has occurred despite repeated warnings, resulting in the manufacturer's decision to stop marketing cisapride in the United States as of July 14, 2000. (crediblemeds.org)
  • Cisapride has not been available in pharmacies since August 2000. (staywellsolutionsonline.com)
  • Cisapride was removed from the US market in 2000, but remained available on the Australian market until 2004. (stenlake.com.au)
  • Velusetrag demonstrates less selectivity for other serotonin receptors, such as 5-HT2 and 5-HT3, to earlier generation 5-HT agonists like cisapride and tegaserod. (wikipedia.org)
  • CONCLUSION The routine use of cisapride in preterm infants cannot be recommended to decrease the time to establish enteral feeds. (bmj.com)
  • tell your doctor and pharmacist if you are allergic to cisapride or any other drugs. (medlineplus.gov)
  • This study was conducted to compare, for the high affinity hERG inhibitors dofetilide and cisapride, hERG blockade between action potential (AP) and conventional (step and step-ramp) screening waveforms. (sussex.ac.uk)
  • The study indicates that cisapride is of limited value in maintenance therapy of GORD in patients in whom symptom relief has been accomplished with potent antisecretory medication. (unboundmedicine.com)
  • This medication, as Cisapride capsules, is also used for felines. (stenlake.com.au)
  • Cisapride capsules has the potential to cause cardiac arrhythmias in humans. (stenlake.com.au)
  • Cisapride is used to treat symptoms of nighttime heartburn in people who have not responded to other treatments. (medlineplus.gov)
  • During post-marketing surveillance, cisapride has been associated with prolongation of the QT interval on the electrocardiogram (ECG). (crediblemeds.org)
  • Lewin MB, Bryant RM, Fenrich AL et al : Cisapride-induced long QT interval. (lhsc.on.ca)
  • Hanson R, Browne G, Fasher B et al : Cisapride-induced prolonged QT interval:too much of a good thing (Letter). (lhsc.on.ca)
  • Bernardini S, Semama DS, Huet F et al: Effects of cisapride on QTc interval in neonates. (lhsc.on.ca)
  • The second group is patients taking medications that inhibit the metabolism of cisapride (eg. (stenlake.com.au)
  • Cisapride is only available in the United States to special patients who are signed up by their doctors. (medlineplus.gov)
  • 4,7,16,56 Subsequently, cisapride was associated with the potentially fatal arrhythmia torsades de pointes when taken with certain medications or in patients who have certain underlying conditions predisposing them to arrhythmias. (crediblemeds.org)
  • 67 However, cisapride will still be available for specific patients, requiring health care providers and patients receiving cisapride to be familiar with the recommendations for reducing risk. (crediblemeds.org)
  • 7,56 Medications that inhibit cytochrome P450 3A4, (Table I), can lead to increased plasma cisapride concentrations in patients. (crediblemeds.org)
  • Recent recommendations by Janssen Pharmaceutica and the FDA have identified patients who may be at risk for this complication associated with cisapride. (crediblemeds.org)
  • All patients should have a 12-lead ECG obtained before initiating cisapride therapy. (crediblemeds.org)
  • Cisapride is contraindicated in patients with electrolyte imbalances (hypokalemia, hypocalcemia and hypomagnesmia). (crediblemeds.org)
  • Stenlake Compounding Chemist expects prescribers to have applied an appropriate risk assessment before prescribing cisapride to their patients. (stenlake.com.au)
  • If you become pregnant while taking cisapride, call your doctor. (medlineplus.gov)
  • Schuurkes et al (1985) Motor-stimulating properties of cisapride on isolated gastrointestinal preparations of the guinea pig. (tocris.com)
  • If your potassium levels are too low, cisapride may have harmful effects on your heart. (webmd.com)
  • In June 1998 the FDA reported there had been 38 deaths potentially attributable to cisapride from 1993-98 in the USA. (stenlake.com.au)
  • If you miss giving your pet a dose of cisapride, give the next dose as soon as you remember or, if it is close to the next scheduled dose, return to the regular schedule. (1800petmeds.com)
  • Cisapride is metabolized primarily by the cytochrome P450 3A4 enzyme. (crediblemeds.org)
  • Cisapride does not abet muscarinic or nicotinic receptor stimulation, nor does it arrest acetylcholinesterase activity. (wordpress.com)
  • cisapride is contraindicated in conditions where stimulation of the GI tract may be dangerous (eg. (lhsc.on.ca)