Cisapride
Gastrointestinal Agents
Simethicone
Domperidone
Serotonin Antagonists
Ether-A-Go-Go Potassium Channels
A family of voltage-gated potassium channels that are characterized by long N-terminal and C-terminal intracellular tails. They are named from the Drosophila protein whose mutation causes abnormal leg shaking under ether anesthesia. Their activation kinetics are dependent on extracellular MAGNESIUM and PROTON concentration.
Gastroesophageal Reflux
Encyclopedias as Topic
Parasympathomimetics
Drugs that mimic the effects of parasympathetic nervous system activity. Included here are drugs that directly stimulate muscarinic receptors and drugs that potentiate cholinergic activity, usually by slowing the breakdown of acetylcholine (CHOLINESTERASE INHIBITORS). Drugs that stimulate both sympathetic and parasympathetic postganglionic neurons (GANGLIONIC STIMULANTS) are not included here.
Acetylcholine
Upper Gastrointestinal Tract
Enteric Nervous System
Two ganglionated neural plexuses in the gut wall which form one of the three major divisions of the autonomic nervous system. The enteric nervous system innervates the gastrointestinal tract, the pancreas, and the gallbladder. It contains sensory neurons, interneurons, and motor neurons. Thus the circuitry can autonomously sense the tension and the chemical environment in the gut and regulate blood vessel tone, motility, secretions, and fluid transport. The system is itself governed by the central nervous system and receives both parasympathetic and sympathetic innervation. (From Kandel, Schwartz, and Jessel, Principles of Neural Science, 3d ed, p766)
Stereoisomerism
Digestive System Physiological Phenomena
Digestive System
Pasteurellosis, Pneumonic
Bovine respiratory disease found in animals that have been shipped or exposed to CATTLE recently transported. The major agent responsible for the disease is MANNHEIMIA HAEMOLYTICA and less commonly, PASTEURELLA MULTOCIDA or HAEMOPHILUS SOMNUS. All three agents are normal inhabitants of the bovine nasal pharyngeal mucosa but not the LUNG. They are considered opportunistic pathogens following STRESS, PHYSIOLOGICAL and/or a viral infection. The resulting bacterial fibrinous BRONCHOPNEUMONIA is often fatal.
Ships
Fatigue Syndrome, Chronic
A syndrome characterized by persistent or recurrent fatigue, diffuse musculoskeletal pain, sleep disturbances, and subjective cognitive impairment of 6 months duration or longer. Symptoms are not caused by ongoing exertion; are not relieved by rest; and result in a substantial reduction of previous levels of occupational, educational, social, or personal activities. Minor alterations of immune, neuroendocrine, and autonomic function may be associated with this syndrome. There is also considerable overlap between this condition and FIBROMYALGIA. (From Semin Neurol 1998;18(2):237-42; Ann Intern Med 1994 Dec 15;121(12): 953-9)
Pleurodynia, Epidemic
Bipolar Disorder
Attention Deficit Disorder with Hyperactivity
A behavior disorder originating in childhood in which the essential features are signs of developmentally inappropriate inattention, impulsivity, and hyperactivity. Although most individuals have symptoms of both inattention and hyperactivity-impulsivity, one or the other pattern may be predominant. The disorder is more frequent in males than females. Onset is in childhood. Symptoms often attenuate during late adolescence although a minority experience the full complement of symptoms into mid-adulthood. (From DSM-V)
Amyotrophic Lateral Sclerosis
A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
Directories as Topic
Cats
The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)
Prescriptions
Naval Medicine
Diagnosis, Oral
Sleep Deprivation
Ambulatory Surgical Procedures
Stomach
Surgicenters
Gastric Balloon
Gastroparesis
Tablets
Interstitial Cells of Cajal
Cellulose
A polysaccharide with glucose units linked as in CELLOBIOSE. It is the chief constituent of plant fibers, cotton being the purest natural form of the substance. As a raw material, it forms the basis for many derivatives used in chromatography, ion exchange materials, explosives manufacturing, and pharmaceutical preparations.
Chromatography, High Pressure Liquid
Intestinal Pseudo-Obstruction
Esophagogastric Junction
Gastrointestinal Transit
Colonic Pseudo-Obstruction
Functional obstruction of the COLON leading to MEGACOLON in the absence of obvious COLONIC DISEASES or mechanical obstruction. When this condition is acquired, acute, and coexisting with another medical condition (trauma, surgery, serious injuries or illness, or medication), it is called Ogilvie's syndrome.
Delayed gastric emptying after Billroth I pylorus-preserving pancreatoduodenectomy: effect of postoperative time and cisapride. (1/188)
OBJECTIVE: To study the recovery course of gastric emptying after Billroth I pylorus-preserving pancreatoduodenectomy (PPPD) and therapeutic effects of cisapride. METHODS: To examine gastric emptying, acetaminophen was given, admixed in a pasty liquid meal, to 16 patients undergoing PPPD before surgery and at 1, 3, 6, 9, and 12 months after surgery. Cisapride was given orally to 10 patients before they received the acetaminophen regimen. Electrogastrography was performed at 2 weeks to 1 month after surgery in eight patients and at 6 to 12 months after surgery in seven patients. RESULTS: Gastric emptying was delayed but returned to the preoperative level by 6 months after surgery. Pretreatment with cisapride accelerated gastric emptying during months 1 to 6 but not during months 6 to 12 after surgery. Electrogastrography frequently showed tachygastria 2 weeks to 1 month after surgery, but seldom 6 to 12 months after surgery. CONCLUSIONS: After Billroth I PPPD, gastric emptying is delayed but recovers by 6 months after surgery. Tachygastria may play a part in the pathogenesis of delayed gastric emptying, but it can be treated with cisapride. (+info)Intestinal prokinesia by two esters of 4-amino-5-chloro-2- methoxybenzoic acid: involvement of 5-hydroxytryptamine-4 receptors and dissociation from cardiac effects in vivo. (2/188)
In five fasting, conscious dogs, we compared the prokinetic action of two selective 5-hydroxytryptamine-4 (5-HT4) receptor agonists with low affinity for 5-HT3 receptors ML10302 (2-piperidinoethyl 4-amino-5-chloro-2-methoxybenzoate) and SR59768 (2-[(3S)-3-hydroxypiperidino]ethyl 4-amino-5-chloro-2-methoxybenzoate) in the duodenum and jejunum, using cisapride as a reference compound. Heart rate and rate-corrected QT (QTc) also were monitored to assess whether or not the cardiac effects of cisapride are shared by other 5-HT4 receptor agonists. Both ML10302 and SR59768 dose-dependently stimulated spike activity in the duodenum with similar potencies (dose range, 3-300 nmol/kg i.v.; ED50 values: 24 and 23 nmol/kg i.v., respectively), mimicking the effect of cisapride (30-3000 nmol/kg i.v.). The maximal effect was achieved with the dose of 100 nmol/kg i.v. for both compounds. Similar findings were obtained in the jejunum. Atropine and GR125487 (1-[2-[(methylsulfonyl)amino]ethyl]-4-piperidinyl-methyl 5-fluoro-2-methoxy-1H-indole-3-carboxylate, selective 5-HT4 receptor antagonist), at doses having no effect per se, antagonized intestinal prokinesia by maximal doses of ML10302 and SR59768. Neither ML10302 nor SR59768 had any effect on heart rate or QTc at any of the doses tested, whereas cisapride, at the highest dose (3000 nmol/kg), induced tachycardia and lengthened the QTC (p <.01). In conclusion, ML10302 and SR59768 share with cisapride a similar prokinetic action in the canine duodenum and jejunum in vivo. This effect is mediated by pathways involving activation of 5-HT4 and muscarinic receptors. Unlike cisapride, which induces tachycardia and prolongs the QTc by a mechanism probably unrelated to 5-HT4 receptor activation, ML10302 and SR59768 are devoid of cardiac effects in this model. (+info)A simple high-performance liquid chromatography assay for the major cisapride metabolite, norcisapride, in human urine. (3/188)
A simple high-performance liquid chromatography assay using fluorescence detection for the major metabolite of the gastric prokinetic drug cisapride, norcisapride, is presented. Analysis is performed using an Alltech Platinum EPS C8 column with a mobile phase made up of methanol and 0.02M sodium dihygrogen phosphate (45:55, v/v) containing triethylamine (1 g/L). Complete resolution is achieved among norcisapride, the internal standard (metoclopramide), and endogenous urinary components. The assay is linear over the range 50-2000 ng/mL with a mean recovery of 71.2% across the analytical range following solvent extraction with toluene-isoamyl alcohol (95:5, v/v). Intraday coefficients of variation (precision) determined at 200 and 1000 ng/mL are 6.0 and 9.8%, respectively, and interday coefficients of variation are 8.8 and 6.6%, respectively. Intra- and interassay accuracy (as mean relative error) determined at the same concentrations is within 10% in all cases. An analysis of urine samples from a healthy volunteer following the administration of a single 10-mg oral dose of cisapride is shown. (+info)Clinical considerations in GERD (gastroesophageal reflux disease) therapy: focus on cisapride. (4/188)
Heartburn, the major symptom of gastrointestinal reflux disease (GERD), is a common condition that is usually self-treated with over-the-counter products. For patients with severe or recurrent symptoms of GERD, pharmacologic therapy includes acid suppression with H2-receptor antagonists and proton pump inhibitors, and, alternatively, the use of prokinetic agents. While all of these are efficacious, given its high efficacy in nonerosive and mild-to-moderate erosive esophagitis, the prokinetic agent cisapride deserves significant consideration in this patient population. (+info)Identification of SK-951, a novel benzofuran derivative, as an agonist to 5-HT4 receptors. (5/188)
The pharmacological profile of SK-951 ((-)4-amino-N-[2-(1-azabicyclo[3.3.0]octan-5-yl) ethyl]-5-chloro-2,3-dihydro-2-methylbenzo[b]furan-7-carboxamide hemifumarate) was identified in relation to serotonin 5-HT3 and 5-HT4 receptors by the receptor binding assay and functional studies. The receptor binding assay showed that SK-951 bound to the 5-HT3 receptor with a high affinity, to the 5-HT4 receptor with relatively higher affinity and to the muscarinic M2 receptor with a low affinity, but not to dopamine D1 and D2 and serotonin 5-HT1 and 5-HT2 and muscarinic M1 and M3 receptors. SK-951 caused relaxations of tunica muscularis mucosae preparations from rat esophagus which were precontracted with carbachol, and the effects were antagonized by GR113808, a selective 5-HT4 antagonist. In the longitudinal muscle with myenteric plexus (LMMP) preparations from guinea pig ileum, SK-951 enhanced the electrically-stimulated contraction of preparations in which the 5-HT1, 5-HT2 and 5-HT3 receptors were blocked, and it enhanced the electrically-stimulated release of [3H]acetylcholine (ACh). These effects of SK-951 were antagonized by GR113808. SK-951 inhibited the 5-HT3 receptor-mediated contractions. These results indicate that SK-951 possesses properties of an agonist for the 5-HT4 receptor and an antagonist for the 5-HT3 receptor. Thus, SK-951 is a new and potent 5-HT4-receptor agonist and causes contractions of guinea pig ileum mediated by enhancement of ACh release via the 5-HT4 receptor. (+info)Randomised controlled trial of cisapride in preterm infants. (6/188)
AIM: To determine the effect of cisapride on gastrointestinal motility in preterm infants. METHODS: Cisapride (0.2 mg/kg, 8 hourly ) or placebo was given first for seven days in a double blind randomised crossover study of 10 preterm infants. Gastrointestinal motility was assessed on day 3 of each treatment. The half gastric emptying time (GET1/2) was determined by using ultrasonography to measure the decrease in the gastric antral cross sectional area after a feed. The whole gastrointestinal transit time (WGTT) was assessed by timing the transit of carmine red through the gut. Treatments were compared using the Wilcoxon matched pairs signed ranks test. RESULTS: Median (range) birthweight was 1200 (620, 1450) g and postconceptional age 33 (29, 34) weeks at recruitment. GET1/2 was significantly longer during cisapride treatment than during placebo; the median of the differences (95% confidence interval) was 19.2 (11, 30 minutes, p=0.008). WGTT was also longer during cisapride treatment, but the difference was not significant; the median of the differences was 11(-18, 52 hours, p=0.1). CONCLUSIONS: Cisapride delays gastric emptying and may delay WGTT in preterm infants. Its use to promote gastrointestinal motility in this group cannot be recommended. (+info)The effect of cisapride on duodenal acid exposure in the proximal duodenum in healthy subjects. (7/188)
AIM: To investigate the effect of the prokinetic drug, cisapride, on fasting and postprandial acid exposure in the proximal duodenum. METHODS: Using a double-blind, placebo-controlled crossover study design, 12 healthy male volunteers were studied. After 1 week of dosing (cisapride 20 mg b.d. orally or placebo), fasting and postprandial antroduodenal pH-and pressure-recordings were made. Using a small-caliber (4 mm) catheter, containing one antral and two duodenal pH electrodes, and two antral and three duodenal pressure recording sites. Transmucosal potential difference was measured to ensure proper catheter position. Infusions of 0.1 N HCl were given in the duodenal bulb. RESULTS: Endogenous acidification of the duodenal bulb occurred more frequently during phase II and postprandially, compared to phase I (P<0.001). During phase I, alkalinization of the antrum was observed. Cisapride significantly increased the postprandial number of duodenal acidic periods (P<0.02), but shortened their duration (P<0.04). The duodenal motor response elicited by exogenous acid was lower during phase I (P<0.05). CONCLUSIONS: Antral and proximal duodenal acidity vary with the phases of the interdigestive motor complex. Cisapride shortens the individual periods of duodenal acidification. (+info)Duodenogastric reflux: clinical and therapeutic aspects. (8/188)
BACKGROUND: Duodenogastric reflux is believed to cause damage to gastric mucosa. Most reports on this disorder concern adult patients. PATIENTS AND METHODS: 1120 children with abdominal pain were studied; endoscopic features of duodenogastric reflux were found in 92 patients. To confirm the diagnosis of duodenogastric reflux, cholescintigraphy (Tc99-HEPIDA) was performed. Children with confirmed duodenogastric reflux by scintigraphy were given a prokinetic drug (cisapride). RESULTS: Endoscopic features of duodenogastric reflux were found in 92 children; the diagnosis was confirmed by scintigraphy in 59 patients. There was no significant difference in the severity of inflammation in gastric mucosa compared with the control group, whereas significantly fewer of these patients were infected with Helicobacter pylori. There was no correlation between regions of isotope accumulation and inflammatory lesions in the stomach. The prokinetic drug (cisapride) helped eliminate or greatly reduce duodenogastric reflux in children. CONCLUSIONS: When endoscopic features of duodenogastric reflux are found the final diagnosis should be based on an examination that does not itself influence the motility of the gastrointestinal tract: cholescintigraphy seems to be a useful method. However, because the use of milk as a test meal affects the scintigraphic image, there was no correlation between the area of isotope accumulation and the localisation of inflammatory lesions in the stomach. Duodenogastric reflux seems to be less important as a cause of inflammatory lesions than other factors (such as genetic predisposition, stress, etc). Prokinetic drugs have a beneficial influence on treatment results in children with inflammatory lesions of gastric mucosa with duodenogastric reflux. (+info)
Identification and characterization of human cytchrome P450 (CYP) isoforms interacting with cisapride<...
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Mechanism of the acetylcholine-release effect of cisapride on guinea-pig gastrointestinal tract<...
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Cisapride does not alter gastric volume or pH in patients undergoing ambulatory surgery.
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An Efficacy and Safety Study of Cisapride in Patients With Chronic Gastroparesis After Failure of Other Treatment Options -...
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PRIME PubMed | Treating the symptoms of gastro-oesophageal reflux disease: a double-blind comparison of omeprazole and cisapride
Evaluation of the clinical efficacy of prokinetic drugs in the management of post-operative ileus: can retrospective data help...
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Investigating dynamic protocol-dependence of hERG potassium channel inhibition at 37 degrees C: Cisapride versus dofetilide :...
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Cisapride is widely available in third world countries, but has been withdrawn in most of the west. It has not been shown to ... Aboumarzouk, Omar M; Agarwal, Trisha; Antakia, Ramez; Shariff, Umar; Nelson, Richard L (19 January 2011). "Cisapride for ...
Phenylpropanolamine
"Unsafe Drugs- nimesulide, Cisapride, Phenylpropanolamine Banned". "Madras High Court Revokes Ban on Manufacture and Sale PPA". ...
Metoclopramide
... is a substituted benzamide; cisapride and mosapride are structurally related. Metoclopramide was first described ...
Grapefruit-drug interactions
626-629 Gross AS, Goh YD, Addison RS, Shenfield GM (April 1999). "Influence of grapefruit juice on cisapride pharmacokinetics ... Examples of such known CYP3A4 inhibitors include cisapride (Propulsid),[citation needed] erythromycin, itraconazole (Sporanox ...
Drug of last resort
... such as cisapride. Aminoglycosides - use of them is extremely restricted due to risk of hearing loss and kidney damage; ... Cisapride - used for severe gastroesophageal reflux disease (GERD); carries risk of heart arrhythmias; Clomethiazole - a ...
Indigestion
Information regarding withdrawal of Propulsid (cisapride) by Janssen Pharmaceutica. From FDA Thompson Coon J, Ernst E (October ... but the studies evaluated to come to this conclusion used the drug cisapride which has since been removed from the market (now ... as one trial suggests potential benefit over placebo and another shows equivalence with cisapride. So, with the somewhat recent ...
Diazepam
Cisapride may enhance the absorption, and therefore the sedative activity, of diazepam. Small doses of theophylline may inhibit ... Bateman DN (1986). "The action of cisapride on gastric emptying and the pharmacodynamics and pharmacokinetics of oral diazepam ...
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5-HT4 receptor
BIMU-8 Cisapride CJ-033,466 - partial agonist ML-10302 Mosapride Prucalopride Renzapride RS-67506 RS-67333 - partial agonist ... "Overexpression of serotonin4 receptors in cisapride-responsive adrenocorticotropin-independent bilateral macronodular adrenal ...
Ritonavir
... cisapride-decreased metabolism, possible prolongation of Q-T interval and life-threatening arrythmias;[medical citation needed ...
Prokinetic agent
As such, the relatively poor selectivity profile of cisapride versus other receptors (especially hERG [human ether-a-go-go K+] ... Some of these prokinetic agents, such as mosapride and cisapride, classic benzamides, have only moderate affinity for 5HT4 ... Benzamide Cisapride Domperidone Itopride Mosapride Metoclopramide Prucalopride Renzapride Tegaserod Mitemcinal Levosulpiride ...
Simeticone
"A randomized placebo-controlled trial of simethicone and cisapride for the treatment of patients with functional dyspepsia". ...
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Medical treatment with laxatives, enemas and prokinetic agents, such as cisapride, does not relieve the burdensome symptoms. ...
Serotonin receptor agonist
Cisapride and tegaserod are 5-HT4 receptor partial agonists that were used to treat disorders of gastrointestinal motility. ...
Intestinal pseudo-obstruction
Prucalopride, pyridostigmine, metoclopramide, cisapride, and erythromycin may be used, but they have not been shown to have ...
Mosapride
... drug information - Drugs Update India Kii Y, Ito T (May 1997). "Effects of 5-HT4-receptor agonists, cisapride, ...
Diazepam
Cisapride may enhance the absorption, and therefore the sedative activity, of diazepam.[78] ... Bateman DN (1986). "The action of cisapride on gastric emptying and the pharmacodynamics and pharmacokinetics of oral diazepam ...
CJ-033466
Toga T, Kohmura Y, Kawatsu R (October 2007). "The 5-HT(4) agonists cisapride, mosapride, and CJ-033466, a Novel potent compound ... In animal tests it stimulated gastrointestinal motility with 30 times the potency of cisapride, and with lower affinity for the ...
Itopride
The affinity of cisapride for 5-HT4 receptors in the heart has been implicated in the undesirable cardiac effects of cisapride ... Itopride belongs to the same benzamide group as cisapride, a drug found to affect QT interval and possibly predispose those ... Moreover, itopride has no affinity for the 5-HT4 receptors, unlike other benzamides such as cisapride and mosapride, which are ... unlike cisapride and mosapride, as it is metabolized by a different enzyme set. New molecular studies on guinea pig ventricular ...
Risperidone
... similar to gastrointestinal drugs such as metoclopramide and cisapride.[medical citation needed] Risperidone undergoes hepatic ...
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Erythromycin
Other examples include terfenadine (Seldane, Seldane-D), astemizole (Hismanal), cisapride (Propulsid, withdrawn in many ...
Velusetrag
... to earlier generation 5-HT agonists like cisapride and tegaserod. In a large clinical trial in patients with chronic idiopathic ...
5-HT3 antagonist
Certain prokinetic drugs such as cisapride, renzapride and metoclopramide, although not 5-HT3 antagonists proper, possess some ...
5-HT4 receptor - Википедија, слободна енциклопедија
2003). „Overexpression of serotonin4 receptors in cisapride-responsive adrenocorticotropin-independent bilateral macronodular ...
Atazanavir
... cisapride, St. John's wort, lovastatin, simvastatin, sildenafil, indinavir, or nevirapine. Common side effects include: nausea ...
5-HT4 receptor
2003). "Overexpression of serotonin4 receptors in cisapride-responsive adrenocorticotropin-independent bilateral macronodular ...
Drug-induced QT prolongation
Fluoroquinolones Ciprofloxacin Levofloxacin Moxifloxacin Chloroquine Cisapride Foscarnet Hydroxychloroquine Ketoconazole ...
Sucralfate
... cisapride + sucralfate can significantly improve symptoms and quality of life and was more cost-effective than ranitidine ...
Cisapride - Wikipedia
"Propulsid (cisapride) Safety Information". Retrieved 2011-07-14.. *^ "Drugs banned in India". Central Drugs Standard Control ... Cisapride is a gastroprokinetic agent, a drug that increases motility in the upper gastrointestinal tract. It acts directly as ... Cisapride has been used for the treatment of gastroesophageal reflux disease (GERD). There is no evidence it is effective for ... Cisapride is still available in the United States and Canada for use in animals, and is commonly prescribed by veterinarians to ...
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Cisapride: MedlinePlus Drug Information
Cisapride: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Cisapride comes as a tablet and liquid to take by mouth. Cisapride usually is taken four times a day, 15 minutes before meals ... Before taking cisapride,. *tell your doctor and pharmacist if you are allergic to cisapride or any other drugs. ... Take cisapride exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. ...
Cisapride Compounded - 1800PetMeds
Buy Cisapride Compounded medication online at 1800PetMeds to help speed up your pets digestive process. Get free shipping on ... Cisapride is usually given at least 30 minutes before feeding.. *Cisapride does not cure the condition for which it is given. ... Cisapride is usually given at least 30 minutes before feeding.. *Cisapride does not cure the condition for which it is given. ... What is Cisapride Compounded?. Cisapride Compounded is used in dogs and cats to speed up the digestive process without ...
Cisapride - Side effect(s)
Interactions between Olmesartan-Amlodipine-Hydrochlorothiazide Oral and potassium-wasting-diuretics-cisapride
... information about interactions between Olmesartan-Amlodipine-Hydrochlorothiazide Oral and potassium-wasting-diuretics-cisapride ... Cisapride/Potassium Wasting Diuretics Interactions. This information is generalized and not intended as specific medical advice ... 1.Prepulsid (cisapride) US prescribing information. Janssen Pharmaceutica Products, L.P. January, 2000. ... If your potassium levels are too low, cisapride may have harmful effects on your heart. ...
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Find the most comprehensive real-world treatment information on Cisapride at PatientsLikeMe. 1 patients with fibromyalgia, ... bipolar I disorder or psoriasis currently take Cisapride. ... Cisapride is a gastrointestinal stimulant used to treat ... What is Cisapride?. Category: Prescription Drugs false ...
What is cisapride? | Technology Trends
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PRIME PubMed | Cisapride for gastro-oesophageal reflux and peptic oesophagitis
Cisapride for gastro-oesophageal reflux and peptic oesophagitis. Download Prime PubMed App to iPhone, iPad, or Android ... Cisapride in the treatment of gastro-oesophageal reflux disease.. *Influence of cisapride on food-stimulated gastro-oesophageal ... "Cisapride for Gastro-oesophageal Reflux and Peptic Oesophagitis." Archives of Disease in Childhood, vol. 62, no. 5, 1987, pp. ... Child, PreschoolCisaprideClinical Trials as TopicDouble-Blind MethodEsophagitis, PepticFemaleGastroesophageal RefluxHumans ...
Cisapride and breastfeeding. Are they compatible?
PRIME PubMed | Cisapride and cimetidine in the treatment of erosive esophagitis
Cisapride and cimetidine in the treatment of erosive esophagitis. Download Prime PubMed App to iPhone, iPad, or Android ... Cisapride for gastroesophageal reflux disease: a placebo-controlled, double-blind study.. *Double-blind comparison of cisapride ... cisapride 20 mg, cimetidine 1600 mg and cimetidine 800 mg. Improvement in reflux symptoms in the two cisapride groups was not ... cisapride 20 mg, cimetidine 1600 mg and cimetidine 800 mg. Improvement in reflux symptoms in the two cisapride groups was not ...
Comparative bioavailability of two immediate release tablets of cisapride in healthy volunteers
Relative bioavailability of cisapride was investigated after oral administration of a test versus a reference formulation of ... immediate release tablets of cisapride, both with 10 mg per unit. The study was conducted in a two-way cross-over design, as a ... Relative bioavailability of cisapride was investigated after oral administration of a test versus a reference formulation of ... Comparative bioavailability of two immediate release tablets of cisapride in healthy volunteers Eur J Drug Metab Pharmacokinet ...
Cisapride - Pet, Dog and Cat Medication and Prescription List | PetMD
Cisapride is given to cats and dogs to help quick passage of food through the digestive tract. Come to petMD for a complete ... Cisapride is given to help with the quick passage of food through the digestive tract. It may be used to treat disorders such ... Cisapride increases the release of acetylcholine, which in turn stimulates the smooth muscle in the digestive tract to contract ... DO NOT GIVE CISAPRIDE TO PETS WITH AN OBSTRUCTION OR PERFORATION IN THEIR DIGESTIVE TRACT ...
Effect of cisapride on gastric and esophageal emptying in insulin-dependent diabetes mellitus
The effects of cisapride on gastric emptying, esophageal emptying, gastrointestinal symptoms, and glycemic control were ... Effect of cisapride on gastric and esophageal emptying in insulin-dependent diabetes mellitus Gastroenterology. 1987 Jun;92(6): ... Single-dose cisapride increased esophageal emptying (p less than 0.01) and both solid and liquid gastric emptying (p less than ... A third gastric and esophageal emptying test was performed after each patient had orally taken 10 mg of cisapride or placebo q. ...
Effects of Cisapride on Corrected QT Interval, Heart Rate, and Rhythm in Infants Undergoing Polysomnography | American Academy...
Effects of Cisapride on Corrected QT Interval, Heart Rate, and Rhythm in Infants Undergoing Polysomnography. Avram Benatar, ... Effects of Cisapride on Corrected QT Interval, Heart Rate, and Rhythm in Infants Undergoing Polysomnography ... Effects of Cisapride on Corrected QT Interval, Heart Rate, and Rhythm in Infants Undergoing Polysomnography ... Effects of Cisapride on Corrected QT Interval, Heart Rate, and Rhythm in Infants Undergoing Polysomnography ...
Pager Forum - General, Beginners and Infants - cisapride/propulsid in Canada?
Cisapride does not alter gastric volume or pH in patients undergoing ambulatory surgery.
METHODS: Using a prospective randomised double-blind controlled design, we administered either 20 mg cisapride ... To evaluate the efficacy of 20 mg cisapride p.o. in reducing residual gastric volume and pH in adult ambulatory surgical ... Cisapride*. Double-Blind Method. Female. Gastrointestinal Contents / chemistry. Hemodynamics / drug effects. Humans. Hydrogen- ... PURPOSE: To evaluate the efficacy of 20 mg cisapride p.o. in reducing residual gastric volume and pH in adult ambulatory ...
Cisapride Supplier | CAS 81098-60-4 | R 51619 | Tocris Bioscience
View and buy high purity Cisapride from Tocris Bioscience. 5-HT4 agonist; stimulates intestinal ACh release. Cited in 4 ... Reviews for Cisapride. There are currently no reviews for this product. Be the first to review Cisapride and earn rewards! ... 4 Citations for Cisapride. Citations are publications that use Tocris products. Selected citations for Cisapride include: ... Keywords: Cisapride, Cisapride supplier, 5-HT4, agonists, stimulates, Serotonin, Receptors, 5-Hydroxytryptamine, stimulate, ACh ...
An Efficacy and Safety Study of Cisapride in Patients With Chronic Gastroparesis After Failure of Other Treatment Options -...
Patients will take study drug (one 10-mg tablet of cisapride, or one tablet of placebo), orally, 4 times a day, for a period of ... Cisapride. Anti-Ulcer Agents. Gastrointestinal Agents. Serotonin Receptor Agonists. Serotonin Agents. Neurotransmitter Agents. ... An Efficacy and Safety Study of Cisapride in Patients With Chronic Gastroparesis After Failure of Other Treatment Options. This ... The purpose of this study is to assess the effectiveness of cisapride in patients with a primary diagnosis of chronic ...
An Efficacy and Safety Study of Cisapride in Patients With Chronic Gastroparesis After Failure of Other Treatment Options -...
An Efficacy and Safety Study of Cisapride in Patients With Chronic Gastroparesis After Failure of Other Treatment Options. The ... Patients will take study drug (one 10-mg tablet of cisapride, or one tablet of placebo), orally, 4 times a day, for a period of ... The purpose of this study is to assess the effectiveness of cisapride in patients with a primary diagnosis of chronic ... Received prior treatment with cisapride. *Have a gycosylated hemoglobin (HbA1c) ,7% and bloodglucose of 126 mg/dL (7.0 mmol/L) ...
Phenomenex HPLC Application #20243: Cisapride on Lux 5µm Cellulose-2 in RP
Phenomenex HPLC Application #20145: Cisapride on Lux 5µm Cellulose-4 in RP
Megacolon, cisapride, enemas. Now can't pee. | Ask A Vet
My cat has Mega Colon and is being treated with CisaPride 5mg/ml suspension. I give 1 and 1/3 ml twice daily or about 1/4 tsp ... He has not had any blood in the urine since then and is only started the Cisapride again this a.m. and only gave him 1 ml and I ... Hello, My cat has Mega Colon and is being treated with CisaPride 5mg/ml suspension. I give 1 and 1/3 ml twice daily or about 1/ ...
Randomised controlled trial of cisapride in feed intolerance in preterm infants | ADC Fetal & Neonatal Edition
Cisapride was well tolerated by all the infants in the study. Janssenet al 4 studied the long term side effects of cisapride at ... Cisapride or placebo was given at a dose of 0.2 ml/kg/dose (cisapride was supplied as 1 mg/ml suspension) four times daily, ... Several cases of prolonged QT interval syndrome due to cisapride have been reported.21-23 The dose of cisapride used in our ... 1990) Cisapride for intractable constipation in children: observations from an open trial. J Pediatr Gastroenterol Nutr 11:503- ...
Cisapride Compound - Available at PetMart Pharmacy
Cisapride compound is specially formulated by our pharmacist to meet your pets needs. Contact us at 877-220-6337 for more ... SKU: PMP544 Categories: For Cats, For Dogs, Non-Sterile Compound, RX Tags: Acid Reflux, cats, Cisapride, Cisapride compound, ... Cisapride Compound Basics. Cisapride Compound treats chronic constipation, megacolon, megaesophagus, and acid reflux disease. ... Cisapride Compound Warnings. Keep out of the reach of children and pets. Do not use in pets with a known allergy or ...
CredibleMeds :: Cisapride
Cisapride should not be given if the QTc is , 450 milliseconds.. *Cisapride is contraindicated in patients with electrolyte ... The Dangers of Cisapride Drug Interactions. Updated April 12, 2000. Since 1995 several labeling changes for cisapride ( ... cisapride will still be available for specific patients, requiring health care providers and patients receiving cisapride to be ... Cisapride is metabolized primarily by the cytochrome P450 3A4 enzyme.7,56Medications that inhibit cytochrome P450 3A4, (Table I ...
Cisapride tablets
... What is this medicine?. CISAPRIDE (SIS a pride) is used to treat heartburn in patients with gastroesophageal ... Cisapride has not been available in pharmacies since August 2000. For information, the manufacturer has provided the following ... an unusual or allergic reaction to cisapride, other medicines, foods, dyes, or preservatives ...
Serotonergic modulating drugs for functional gastrointestinal diseases - Spiller - 2002 - British Journal of Clinical...
Cisapride. Cisaprides prokinetic effects probably depend on its 5HT4 agonist properties [73]. It accelerates gastric emptying ... Effect of cisapride on the gastrointestinal transit of a solid meal in normal human subjects. Gut 1987; 28: 13-16.. *CrossRef ... Cisapride. Motor neurones. Stimulates increased amplitude of oesphageal peristalsis contractions and lower oesphageal sphineter ... The influence of cisapride on gastric tone and the perception of gastric distension. Aliment Pharmacol Ther 1998; 12: 761-766. ...
Cisapride medication guide
Cisapride is prescribed to animals suffering from conditions that compromise stomach motility. Visit VetDepot for more helpful ... Cisapride is available in liquid and tablet form. A typical dose range for Cisapride is 0.1 mg-0.5 mg/kg PO 2 to 3 times per ... Cisapride should not be administered in animals with a known allergy or hypersensitivity to the drug. Cisapride may interact ... Cisapride can also be used to manage constipation in cats.. Common Precautions. Side effects most commonly associated with ...
PropulsidEffects of cisaprideTreatment with cisaprideAdministration of cisaprideMotilityMetoclopramideGastricProkinetic agentTabletsIntestinalIncreases esophagealDosagePlaceboResulting in the manufacturer'sPatients receivingEffect of cisaprideGastro-oesophageal refluxMedicationCimetidineEsophagealEfficacyPrepulsidJanssen PharmaceuticaMegacolon2000DrugsRelease of acetylcholineGastroparesisBioavailabilityGastroesophageal refluxMedicationsSignificantlyInhibitInfantsConstipationSerotoninMetabolismStomachRanitidineIntervalSymptomsDofetilideMonohydrateAbdominalErythromycinDiarrhoea1993Side-effectsCOMPOUNDDrugCardiac arrhythmias1990Esomeprazole
Propulsid3
- cisapride/propulsid in Canada? (reflux.org)
- Hi, I live in NY close to the Canadian border and wondered if Cisapride/Propulsid is available there? (reflux.org)
- Since 1995 several labeling changes for cisapride (Propulsid, Janssen Pharmaceutica) have been required by the Food and Drug Administration (FDA) following serious adverse effects that were reported through the MedWatch reporting program. (crediblemeds.org)
Effects of cisapride4
- Read the side effects of Cisapride as described in the medical literature. (medindia.net)
- The effects of cisapride on gastric emptying, esophageal emptying, gastrointestinal symptoms, and glycemic control were evaluated in 20 insulin-dependent diabetics who had delayed gastric emptying of the solid or liquid component of a meal, or both. (nih.gov)
- Bernardini S, Semama DS, Huet F et al: Effects of cisapride on QTc interval in neonates. (lhsc.on.ca)
- The effects of cisapride and renzapride (BRL 24924), on plasma concentration of motilin and gastroduodenal motility were studied in seven dogs with implanted force transducers in the antrum and duodenum. (elsevier.com)
Treatment with cisapride2
- They showed a significant reduction in gastric residuals after 48 hours of treatment with cisapride. (bmj.com)
- Serum electrolytes should be evaluated in patients treated with diuretics prior to initiating cisapride and periodically thereafter during treatment with cisapride. (crediblemeds.org)
Administration of cisapride4
- After administration of cisapride for 4 wk, gastric emptying of solid and liquid were faster (p less than 0.001), but esophageal emptying was not significantly different from the placebo test. (nih.gov)
- These results indicate that single-dose cisapride increases esophageal emptying in insulin-dependent diabetics and that chronic administration of cisapride is effective in the treatment of diabetic gastroparesis. (nih.gov)
- 05). Conclusions and Clinical Relevance: Preanesthetic administration of cisapride and esomeprazole decreases the number of RE in anesthetized dogs, but administration of esomeprazole alone was associated with nonacid and weakly acidic reflux in all but 1 dog. (elsevier.com)
- In the interdigestive state, the i.v. administration of cisapride (5 mg) or renzapride (5 mg) administered in phase I resulted in a prompt and marked increase in plasma motilin concentration and in gastroduodenal motility. (elsevier.com)
Motility7
- Cisapride is a gastroprokinetic agent , a drug that increases motility in the upper gastrointestinal tract . (wikipedia.org)
- As a prokinetic agent that increases gastrointestinal motility , cisapride acts as a selective serotonin agonist in the 5-HT 4 receptor subtype. (wikipedia.org)
- Serotonin-agonising laxatives Benzamide Domperidone Drug of last resort Itopride Metoclopramide Mosapride US patent 5955478, Gray NM, Young JW, "Methods for treating gastrointestinal motility dysfunction using optically pre (+) cisapride", issued 1999-Sep-21 Maclennan S, Augood C, Cash-Gibson L, Logan S, Gilbert RE (April 2010). (wikipedia.org)
- Cisapride is a first line gastrointestinal prokinetic agent for treating motility disorders in children. (bmj.com)
- Cisapride is a gastrointestinal prokinetic that is most commonly used to treat conditions that compromise stomach motility and delay gastric emptying. (vetdepot.com)
- Cisapride indirectly improves GI motility by promoting acetylcholine release from postganglionic nerve endings in the myenteric plexus. (medscape.com)
- We conclude that cisapride and renzapride have similar effects on plasma motilin and gastroduodenal motility: 1) the two drugs increase plasma motilin levels and stimulate gastroduodenal motility in the interdigestive state, and 2) in the digestive state, both drugs enhance motility without influencing the plasma motilin levels. (elsevier.com)
Metoclopramide1
- Cisapride is also commonly used to treat GI stasis in rabbits, sometimes in conjunction with metoclopramide (Reglan). (wikipedia.org)
Gastric13
- On 2 days each patient received cisapride (20 mg) or placebo orally, 60 min before an esophageal and gastric emptying test. (nih.gov)
- A third gastric and esophageal emptying test was performed after each patient had orally taken 10 mg of cisapride or placebo q.i.d. for 4 wk. (nih.gov)
- Single-dose cisapride increased esophageal emptying (p less than 0.01) and both solid and liquid gastric emptying (p less than 0.001). (nih.gov)
- The response to cisapride was most marked in patients with the greatest delay in esophageal and gastric emptying (p less than 0.05). (nih.gov)
- Cisapride does not alter gastric volume or pH in patients undergoing ambulatory surgery. (biomedsearch.com)
- PURPOSE: To evaluate the efficacy of 20 mg cisapride p.o. in reducing residual gastric volume and pH in adult ambulatory surgical patients. (biomedsearch.com)
- RESULTS: Residual gastric volumes were similar in the two groups (19.5 +/- 23.8, 23.9 +/- 24.4 ml), in the cisapride and placebo groups respectively, P=0.24). (biomedsearch.com)
- The proportions of patients with a residual gastric volume exceeding 0.4 ml x kg(-1) were similar in the two groups (4 of 28, and 8 of 23 patients in the cisapride and placebo groups respectively, P=0.09). (biomedsearch.com)
- The pH of the residual gastric contents were similar in the cisapride and placebo groups (1.6 +/- 0.5, 1.4 +/- 0.5, respectively, P=0.26). (biomedsearch.com)
- CONCLUSIONS: Preoperative administration of 20 mg cisapride p.o. to patients scheduled for outpatient surgery does not alter either the volume or the pH of gastric contents. (biomedsearch.com)
- Cisapride stimulates action of the high gastrointestinal amplitude after aesthetic gastric, biliary, or pancreatic secretions. (wordpress.com)
- Cisapride is used to treat gastric reflux (the regurgitation of stomach acid into the esophagus), which is usually experienced as heartburn. (vasudhapharma.com)
- Cisapride is an effective prokinetic agent in the treatment of gastric stasis of the vagally denervated intrathoracic stomach . (bvsalud.org)
Prokinetic agent2
- Twenty children (age range 75 days-47 months) with reflux oesophagitis entered a random double blind trial in which they received either Cisapride (Janssen Pharmaceutical Ltd), a new prokinetic agent, or an identical placebo syrup. (unboundmedicine.com)
- Cisapride is a potent third generation prokinetic agent acting on postganglionic receptors by increasing the release of acetylcholine. (elsevier.com)
Tablets3
- Relative bioavailability of cisapride was investigated after oral administration of a test versus a reference formulation of immediate release tablets of cisapride, both with 10 mg per unit. (nih.gov)
- The two formulations were administered in two treatment days , separated by a washout period of 6 days, in fasted subjects who received one single oral dose of 20 mg of one study medication of cisapride as two 10 mg tablets. (nih.gov)
- Cisapride tablets should be stored in a tight, light-resistant container and kept at room temperature. (vetdepot.com)
Intestinal2
- Cisapride Compound increases intestinal muscle contractions in animals that suffer from food compaction. (petmartpharmacy.com)
- Cisapride is used in small animals to stimulate intestinal contractions, and to treat chronic constipation or other conditions where food and waste materials have stopped moving through the gastrointestinal tract. (catdoc.com)
Increases esophageal2
- Objective: To determine whether preanesthetic IV administration of esomeprazole alone or esomeprazole and cisapride increases esophageal pH and decreases the frequency of GER in anesthetized dogs using combined multichannel impedance and pH monitoring. (elsevier.com)
- cisapride is a gastrokinetic drug that increases esophageal peristaltic activity and lower esophageal sphincter tone. (lhsc.on.ca)
Dosage2
- One hundred and twenty-nine patients were assigned to one of four dosage schedules: cisapride 10 mg b.i.d. (20 mg group) or q.i.d. (40 mg group), or cimetidine 400 mg b.i.d. (800 mg group) or q.i.d. (1600 mg group). (unboundmedicine.com)
- Bedu A, Lupoglazoff JM, Faure C et al : Cisapride high dosage and long QT interval (Letter). (lhsc.on.ca)
Placebo11
- Mean total clinical score and post-prandial reflux time (% of reflux) significantly improved in patients in the group given Cisapride but not in the group given placebo. (unboundmedicine.com)
- Furthermore, there was a significant improvement of the histological oesophagitis score only in the children in the group given Cisapride, whereas placebo was ineffective. (unboundmedicine.com)
- Upper gastrointestinal symptoms were less after cisapride (p less than 0.05), whereas there was no change on placebo (p greater than 0.2). (nih.gov)
- Plasma glucose and glycosylated hemoglobin concentrations were not different after cisapride compared with placebo. (nih.gov)
- METHODS: Using a prospective randomised double-blind controlled design, we administered either 20 mg cisapride p.o. or placebo preoperatively to 64 ASA 1-2 ambulatory surgical patients. (biomedsearch.com)
- 2.5 was also similar in the cisapride and placebo groups (21 of 25, and 20 of 21 patients respectively, P=0.2). (biomedsearch.com)
- Double-Blind, Randomized, Placebo-Controlled Trial To Assess Efficacy And Safety Of R051619 (Cisapride 10 mg q.i.d. (clinicaltrials.gov)
- Patients will take study drug (one 10-mg tablet of cisapride, or one tablet of placebo), orally, 4 times a day, for a period of 8 weeks. (clinicaltrials.gov)
- METHODS A randomised, double blind, placebo controlled trial was conducted of 34 infants of ⩽ 32 weeks of gestation, assigned to receive either cisapride 0.2 mg/kg/dose four times daily (n=18) or placebo (n=16). (bmj.com)
- We conducted a randomised, double blind, placebo controlled trial to evaluate the efficacy of cisapride in improving feed tolerance in preterm infants of less than 33 weeks gestation at birth. (bmj.com)
- After enrolment each infant was randomly assigned to receive either cisapride or placebo by a double blind parallel group design in blocks of 10. (bmj.com)
Resulting in the manufacturer's1
- 67 This has occurred despite repeated warnings, resulting in the manufacturer's decision to stop marketing cisapride in the United States as of July 14, 2000. (crediblemeds.org)
Patients receiving2
- 67 However, cisapride will still be available for specific patients, requiring health care providers and patients receiving cisapride to be familiar with the recommendations for reducing risk. (crediblemeds.org)
- There have been a few cases of disturbances in liver function among patients receiving cisapride. (pocketdrugguide.com)
Effect of cisapride1
- Chen, HT & Pan, S 1988, ' Mechanism of the acetylcholine-release effect of cisapride on guinea-pig gastrointestinal tract ', Chinese Medical Journal (Taipei) , vol. 41, no. 4, pp. 263-270. (elsevier.com)
Gastro-oesophageal reflux2
- It is concluded that Cisapride is a useful agent both for the relief of symptoms of gastro-oesophageal reflux and for the healing of peptic oesophagitis in infancy. (unboundmedicine.com)
- TY - JOUR T1 - Cisapride for gastro-oesophageal reflux and peptic oesophagitis. (unboundmedicine.com)
Medication1
- This medication, as Cisapride capsules, is also used for felines. (stenlake.com.au)
Cimetidine5
- The efficacy of cisapride, as compared with cimetidine, in the treatment of erosive esophagitis was studied in a double-blind trial. (unboundmedicine.com)
- Endoscopy did not show any significant differences among the four groups, although cisapride tended to be more effective in moderate to severe esophagitis, in which cases mucosal healing (i.e. absence of erosions and ulcers) was observed in 69%, 64%, 55% and 55% of the patients treated with cisapride 40 mg, cisapride 20 mg, cimetidine 1600 mg and cimetidine 800 mg. (unboundmedicine.com)
- Improvement in reflux symptoms in the two cisapride groups was not significantly different from that in the cimetidine 1600 mg group, but was better (p less than 0.05) than that in the cimetidine 800 mg patients. (unboundmedicine.com)
- The severity score for all reflux symptoms had decreased by 79%, 74% (cisapride 40 mg and 20 mg), 69% and 57% (cimetidine 1600 mg and 800 mg) by the end of treatment. (unboundmedicine.com)
- TY - JOUR T1 - Cisapride and cimetidine in the treatment of erosive esophagitis. (unboundmedicine.com)
Esophageal3
- In a prospective, self-controlled study the prokinetic action of cisapride was tested on pedicled stomach, jejunum and colon grafts used for substitute after esophageal resection. (elsevier.com)
- Esophageal transit scintigraphy was performed before and after cisapride administration. (elsevier.com)
- Cisapride exerts prokinetic effect on pedicled stomach and jejunum substitutes after esophageal resection. (elsevier.com)
Efficacy2
Prepulsid2
- 1.Prepulsid (cisapride) US prescribing information. (webmd.com)
- Some generic versions exist of medications have different ratios of active documents and inactive ingredients, Prepulsid sus 1mg/ml stronger than cisapride. (thecollectibleornamentshoppe.com)
Janssen Pharmaceutica1
- Recent recommendations by Janssen Pharmaceutica and the FDA have identified patients who may be at risk for this complication associated with cisapride. (crediblemeds.org)
Megacolon2
- Cisapride is still available in the United States and Canada for use in animals, and is commonly prescribed by veterinarians to treat megacolon in cats. (wikipedia.org)
- Megacolon, cisapride, enemas. (askavetquestion.com)
20004
- The U.S. Food and Drug Administration (FDA) issued a warning letter to doctors, [4] and cisapride was voluntarily removed from the U.S. market on July 14, 2000. (wikipedia.org)
- Cisapride has not been available in pharmacies since August 2000. (staywellsolutionsonline.com)
- Cisapride was removed from the US market in 2000, but remained available on the Australian market until 2004. (stenlake.com.au)
- In the wake of Vanessa's death in 2000, her grieving father is "dumbfounded" to read a Los Angeles Times exposé showing that both the manufacturer and the FDA knew as early as 1993 about cisapride-induced dysrhythmias. (cmaj.ca)
Drugs3
- tell your doctor and pharmacist if you are allergic to cisapride or any other drugs. (medlineplus.gov)
- Cisapride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs . (tocris.com)
- Most patients were either receiving other drugs known to impair cisapride metabolism (see Interactions, below) or had other factors predisposing to arrhythmias. (pocketdrugguide.com)
Release of acetylcholine2
- Cisapride also relieves constipation-like symptoms by indirectly stimulating the release of acetylcholine , which acts on muscarinic receptors . (wikipedia.org)
- Cisapride increases the release of acetylcholine, which in turn stimulates the smooth muscle in the digestive tract to contract more frequently. (petmd.com)
Gastroparesis1
- The purpose of this study is to assess the effectiveness of cisapride in patients with a primary diagnosis of chronic gastroparesis (a stomach disorder) of unknown cause. (clinicaltrials.gov)
Bioavailability1
- Comparative bioavailability of a cisapride suppository and tablet formulation in healthy volunteers" European Journal of Clinical Pharmacology T Hedner et al. (gutenberg.org)
Gastroesophageal reflux2
- Cisapride has been used for the treatment of gastroesophageal reflux disease (GERD). (wikipedia.org)
- CISAPRIDE (SIS a pride) is used to treat heartburn in patients with gastroesophageal reflux disease (GERD). (staywellsolutionsonline.com)
Medications5
- Cisapride may interact with some other medications. (petmartpharmacy.com)
- 4,7,16,56 Subsequently, cisapride was associated with the potentially fatal arrhythmia torsades de pointes when taken with certain medications or in patients who have certain underlying conditions predisposing them to arrhythmias. (crediblemeds.org)
- 7,56 Medications that inhibit cytochrome P450 3A4, (Table I), can lead to increased plasma cisapride concentrations in patients. (crediblemeds.org)
- Cisapride may interact with other medications including anticholinergic agents, benzodiazepines, and warfarin. (vetdepot.com)
- The second group is patients taking medications that inhibit the metabolism of cisapride (eg. (stenlake.com.au)
Significantly2
- The formation rate of M1 and 10μM cisapride in 15 HLMs significantly correlated with the activities of CYP3A, 2C19 and 1A2. (elsevier.com)
- Cisapride significantly reduced the half-life of radiolabeled bolus in the substitute in the case of stomach and jejunum replacement, while for colon replacement the results were dispersed too widely to yield significant difference. (elsevier.com)
Inhibit1
- Cisapride appears to inhibit CYP2D6-mediated metabolism in a stereoselective manner. (elsevier.com)
Infants1
- CONCLUSION The routine use of cisapride in preterm infants cannot be recommended to decrease the time to establish enteral feeds. (bmj.com)
Constipation1
- Cisapride can also be used to manage constipation in cats. (vetdepot.com)
Serotonin2
- Cisapride is a parasympathomimetic which acts as a serotonin 5-HT4 agonist. (wordpress.com)
- Cisapride acts through the stimulation of the serotonin 5-HT 4 receptors which increases acetylcholine release in the enteric nervous system (specifically the myenteric plexus). (selfdecode.com)
Metabolism1
- Using human liver microsomes (HLMs) and recombinant CYP450s, we characterized the metabolism of cisapride and documented its inhibitory effect on CYP450s. (elsevier.com)
Stomach2
- Cisapride is an effective medicine, used to increase the mobility of food in the stomach and intestine. (practo.com)
- Effect of erythromycin and cisapride on emptying of the vagally denervated intrathoracic stomach. (bvsalud.org)
Ranitidine1
- Liquid chromatographic determination including simultaneous 'on-cartridge' separation of ranitidine cisapride drug combinations from paediatric plasma samples using an automated solid-phase extraction procedure. (cngb.org)
Interval5
- During post-marketing surveillance, cisapride has been associated with prolongation of the QT interval on the electrocardiogram (ECG). (crediblemeds.org)
- Subsequent reports implicated cisapride in the development of prolonged QT interval and torsade de pointes or ventricular fibrillation or both. (pocketdrugguide.com)
- Neonates (especially of low gestational age) are vulnerable to cisapride-induced QT interval prolongation, and the CSM also specifically contra-indicated use in premature neonates and noted that there were insufficient data to support use in children up to the age of 12. (pocketdrugguide.com)
- Lewin MB, Bryant RM, Fenrich AL et al : Cisapride-induced long QT interval. (lhsc.on.ca)
- Hanson R, Browne G, Fasher B et al : Cisapride-induced prolonged QT interval:too much of a good thing (Letter). (lhsc.on.ca)
Symptoms1
- Cisapride is used to treat symptoms of nighttime heartburn in people who have not responded to other treatments. (medlineplus.gov)
Dofetilide3
- This study was conducted to compare, for the high affinity hERG inhibitors dofetilide and cisapride, hERG blockade between action potential (AP) and conventional (step and step-ramp) screening waveforms. (sussex.ac.uk)
- A more marked variation in IC(50) values with different command waveforms was observed for cisapride (ranging from 7 to 72 nM) than for dofetilide (ranging from 4 to 15 nM), with higher IC(50)s obtained with AP than step or step-ramp commands. (sussex.ac.uk)
- Features of time-dependence of blockade and the use of protocols employing varying rest periods in drug or commands of alternating duration highlighted a pronounced ability of cisapride, but not dofetilide, to dissociate and reassociate from hERG on a pulse-by-pulse basis. (sussex.ac.uk)
Monohydrate3
- We are proud to introduce ourselves as one of the best Cisapride Monohydrate Exporters in the pharmaceutical industry. (vasudhapharma.com)
- Vasudha Pharma( Cisapride Monohydrate Exporters ) the above results indicated that the cisapride is safe and effective to use. (vasudhapharma.com)
- Cisapnde Monohydrate Cisapride BP 2008). (pocketdrugguide.com)
Abdominal3
- Side effects most commonly associated with Cisapride are abdominal pain, vomiting, and diarrhea. (vetdepot.com)
- Cisapride increases the accent and amplitude of belly (especially antral) contractions, relaxes the pyloric sphincter and the belly bulb, and increases peristalsis of the duodenum and jejunum consistent in accelerated belly elimination and abdominal transit. (wordpress.com)
- The most commonly reported adverse effects with cisapride are gastrointestinal disturbances including abdominal cramps, borborygmi, and diarrhoea . (pocketdrugguide.com)
Erythromycin1
- The patients in group A received erythromycin , while patients in group B received cisapride . (bvsalud.org)
Diarrhoea1
- A comparison of data from prescription-event monitoring in over 13 000 recipients of cisapride and from a further 9726 recipients involved in a controlled study showed that diarrhoea, in about 2 to 4% of patients, was the commonest adverse effect reported. (pocketdrugguide.com)
19931
- In June 1998 the FDA reported there had been 38 deaths potentially attributable to cisapride from 1993-98 in the USA. (stenlake.com.au)
Side-effects1
- Cisapride may cause side effects. (medlineplus.gov)
COMPOUND1
- Cisapride Compound requires a prescription from your veterinarian. (petmartpharmacy.com)
Drug6
- Cisapride should not be administered in animals with a known allergy or hypersensitivity to the drug. (vetdepot.com)
- In 1996, the Australian Drug Reaction Advisory Committee (ADRAC) reported nine cases of cardiac arrhythmia associated with cisapride. (stenlake.com.au)
- Seven reports of cardiac effects associated with cisapride were submitted to the WHO Programme for International Drug Monitoring between 1989 and 1991. (pocketdrugguide.com)
- In conclusion, cisapride is metabolized by multiple CYP450s in vitro which may make prediction of cisapride drug interaction and cardiac toxicity more difficult than described in the manufacturer's labels. (elsevier.com)
- however, I(hERG) blockade by each drug was initially voltage-dependent, but at steady-state was only voltage-dependent for cisapride. (sussex.ac.uk)
- Protocols described here that demonstrated dynamic variation (drug dissociation/reassociation) in hERG channel current blockade at 37 degrees C for cisapride may have future value for investigating drug interactions with the hERG channel. (sussex.ac.uk)
Cardiac arrhythmias1
- Cisapride capsules has the potential to cause cardiac arrhythmias in humans. (stenlake.com.au)
19901
- Murdoch J: Cisapride, Pharmacy Practice 1990 (June): 23-25. (lhsc.on.ca)
Esomeprazole1
- Dogs were randomized to receive IV saline (0.9% NaCl), esomeprazole (1 mg/kg) alone, or a combination of esomeprazole (1 mg/kg) and cisapride (1 mg/kg) 12-18 hours and 1-1.5 hours before anesthetic induction. (elsevier.com)