Cisapride
Gastrointestinal Agents
Simethicone
Domperidone
Serotonin Antagonists
Ether-A-Go-Go Potassium Channels
A family of voltage-gated potassium channels that are characterized by long N-terminal and C-terminal intracellular tails. They are named from the Drosophila protein whose mutation causes abnormal leg shaking under ether anesthesia. Their activation kinetics are dependent on extracellular MAGNESIUM and PROTON concentration.
Delayed gastric emptying after Billroth I pylorus-preserving pancreatoduodenectomy: effect of postoperative time and cisapride. (1/188)
OBJECTIVE: To study the recovery course of gastric emptying after Billroth I pylorus-preserving pancreatoduodenectomy (PPPD) and therapeutic effects of cisapride. METHODS: To examine gastric emptying, acetaminophen was given, admixed in a pasty liquid meal, to 16 patients undergoing PPPD before surgery and at 1, 3, 6, 9, and 12 months after surgery. Cisapride was given orally to 10 patients before they received the acetaminophen regimen. Electrogastrography was performed at 2 weeks to 1 month after surgery in eight patients and at 6 to 12 months after surgery in seven patients. RESULTS: Gastric emptying was delayed but returned to the preoperative level by 6 months after surgery. Pretreatment with cisapride accelerated gastric emptying during months 1 to 6 but not during months 6 to 12 after surgery. Electrogastrography frequently showed tachygastria 2 weeks to 1 month after surgery, but seldom 6 to 12 months after surgery. CONCLUSIONS: After Billroth I PPPD, gastric emptying is delayed but recovers by 6 months after surgery. Tachygastria may play a part in the pathogenesis of delayed gastric emptying, but it can be treated with cisapride. (+info)Intestinal prokinesia by two esters of 4-amino-5-chloro-2- methoxybenzoic acid: involvement of 5-hydroxytryptamine-4 receptors and dissociation from cardiac effects in vivo. (2/188)
In five fasting, conscious dogs, we compared the prokinetic action of two selective 5-hydroxytryptamine-4 (5-HT4) receptor agonists with low affinity for 5-HT3 receptors ML10302 (2-piperidinoethyl 4-amino-5-chloro-2-methoxybenzoate) and SR59768 (2-[(3S)-3-hydroxypiperidino]ethyl 4-amino-5-chloro-2-methoxybenzoate) in the duodenum and jejunum, using cisapride as a reference compound. Heart rate and rate-corrected QT (QTc) also were monitored to assess whether or not the cardiac effects of cisapride are shared by other 5-HT4 receptor agonists. Both ML10302 and SR59768 dose-dependently stimulated spike activity in the duodenum with similar potencies (dose range, 3-300 nmol/kg i.v.; ED50 values: 24 and 23 nmol/kg i.v., respectively), mimicking the effect of cisapride (30-3000 nmol/kg i.v.). The maximal effect was achieved with the dose of 100 nmol/kg i.v. for both compounds. Similar findings were obtained in the jejunum. Atropine and GR125487 (1-[2-[(methylsulfonyl)amino]ethyl]-4-piperidinyl-methyl 5-fluoro-2-methoxy-1H-indole-3-carboxylate, selective 5-HT4 receptor antagonist), at doses having no effect per se, antagonized intestinal prokinesia by maximal doses of ML10302 and SR59768. Neither ML10302 nor SR59768 had any effect on heart rate or QTc at any of the doses tested, whereas cisapride, at the highest dose (3000 nmol/kg), induced tachycardia and lengthened the QTC (p <.01). In conclusion, ML10302 and SR59768 share with cisapride a similar prokinetic action in the canine duodenum and jejunum in vivo. This effect is mediated by pathways involving activation of 5-HT4 and muscarinic receptors. Unlike cisapride, which induces tachycardia and prolongs the QTc by a mechanism probably unrelated to 5-HT4 receptor activation, ML10302 and SR59768 are devoid of cardiac effects in this model. (+info)A simple high-performance liquid chromatography assay for the major cisapride metabolite, norcisapride, in human urine. (3/188)
A simple high-performance liquid chromatography assay using fluorescence detection for the major metabolite of the gastric prokinetic drug cisapride, norcisapride, is presented. Analysis is performed using an Alltech Platinum EPS C8 column with a mobile phase made up of methanol and 0.02M sodium dihygrogen phosphate (45:55, v/v) containing triethylamine (1 g/L). Complete resolution is achieved among norcisapride, the internal standard (metoclopramide), and endogenous urinary components. The assay is linear over the range 50-2000 ng/mL with a mean recovery of 71.2% across the analytical range following solvent extraction with toluene-isoamyl alcohol (95:5, v/v). Intraday coefficients of variation (precision) determined at 200 and 1000 ng/mL are 6.0 and 9.8%, respectively, and interday coefficients of variation are 8.8 and 6.6%, respectively. Intra- and interassay accuracy (as mean relative error) determined at the same concentrations is within 10% in all cases. An analysis of urine samples from a healthy volunteer following the administration of a single 10-mg oral dose of cisapride is shown. (+info)Clinical considerations in GERD (gastroesophageal reflux disease) therapy: focus on cisapride. (4/188)
Heartburn, the major symptom of gastrointestinal reflux disease (GERD), is a common condition that is usually self-treated with over-the-counter products. For patients with severe or recurrent symptoms of GERD, pharmacologic therapy includes acid suppression with H2-receptor antagonists and proton pump inhibitors, and, alternatively, the use of prokinetic agents. While all of these are efficacious, given its high efficacy in nonerosive and mild-to-moderate erosive esophagitis, the prokinetic agent cisapride deserves significant consideration in this patient population. (+info)Identification of SK-951, a novel benzofuran derivative, as an agonist to 5-HT4 receptors. (5/188)
The pharmacological profile of SK-951 ((-)4-amino-N-[2-(1-azabicyclo[3.3.0]octan-5-yl) ethyl]-5-chloro-2,3-dihydro-2-methylbenzo[b]furan-7-carboxamide hemifumarate) was identified in relation to serotonin 5-HT3 and 5-HT4 receptors by the receptor binding assay and functional studies. The receptor binding assay showed that SK-951 bound to the 5-HT3 receptor with a high affinity, to the 5-HT4 receptor with relatively higher affinity and to the muscarinic M2 receptor with a low affinity, but not to dopamine D1 and D2 and serotonin 5-HT1 and 5-HT2 and muscarinic M1 and M3 receptors. SK-951 caused relaxations of tunica muscularis mucosae preparations from rat esophagus which were precontracted with carbachol, and the effects were antagonized by GR113808, a selective 5-HT4 antagonist. In the longitudinal muscle with myenteric plexus (LMMP) preparations from guinea pig ileum, SK-951 enhanced the electrically-stimulated contraction of preparations in which the 5-HT1, 5-HT2 and 5-HT3 receptors were blocked, and it enhanced the electrically-stimulated release of [3H]acetylcholine (ACh). These effects of SK-951 were antagonized by GR113808. SK-951 inhibited the 5-HT3 receptor-mediated contractions. These results indicate that SK-951 possesses properties of an agonist for the 5-HT4 receptor and an antagonist for the 5-HT3 receptor. Thus, SK-951 is a new and potent 5-HT4-receptor agonist and causes contractions of guinea pig ileum mediated by enhancement of ACh release via the 5-HT4 receptor. (+info)Randomised controlled trial of cisapride in preterm infants. (6/188)
AIM: To determine the effect of cisapride on gastrointestinal motility in preterm infants. METHODS: Cisapride (0.2 mg/kg, 8 hourly ) or placebo was given first for seven days in a double blind randomised crossover study of 10 preterm infants. Gastrointestinal motility was assessed on day 3 of each treatment. The half gastric emptying time (GET1/2) was determined by using ultrasonography to measure the decrease in the gastric antral cross sectional area after a feed. The whole gastrointestinal transit time (WGTT) was assessed by timing the transit of carmine red through the gut. Treatments were compared using the Wilcoxon matched pairs signed ranks test. RESULTS: Median (range) birthweight was 1200 (620, 1450) g and postconceptional age 33 (29, 34) weeks at recruitment. GET1/2 was significantly longer during cisapride treatment than during placebo; the median of the differences (95% confidence interval) was 19.2 (11, 30 minutes, p=0.008). WGTT was also longer during cisapride treatment, but the difference was not significant; the median of the differences was 11(-18, 52 hours, p=0.1). CONCLUSIONS: Cisapride delays gastric emptying and may delay WGTT in preterm infants. Its use to promote gastrointestinal motility in this group cannot be recommended. (+info)The effect of cisapride on duodenal acid exposure in the proximal duodenum in healthy subjects. (7/188)
AIM: To investigate the effect of the prokinetic drug, cisapride, on fasting and postprandial acid exposure in the proximal duodenum. METHODS: Using a double-blind, placebo-controlled crossover study design, 12 healthy male volunteers were studied. After 1 week of dosing (cisapride 20 mg b.d. orally or placebo), fasting and postprandial antroduodenal pH-and pressure-recordings were made. Using a small-caliber (4 mm) catheter, containing one antral and two duodenal pH electrodes, and two antral and three duodenal pressure recording sites. Transmucosal potential difference was measured to ensure proper catheter position. Infusions of 0.1 N HCl were given in the duodenal bulb. RESULTS: Endogenous acidification of the duodenal bulb occurred more frequently during phase II and postprandially, compared to phase I (P<0.001). During phase I, alkalinization of the antrum was observed. Cisapride significantly increased the postprandial number of duodenal acidic periods (P<0.02), but shortened their duration (P<0.04). The duodenal motor response elicited by exogenous acid was lower during phase I (P<0.05). CONCLUSIONS: Antral and proximal duodenal acidity vary with the phases of the interdigestive motor complex. Cisapride shortens the individual periods of duodenal acidification. (+info)Duodenogastric reflux: clinical and therapeutic aspects. (8/188)
BACKGROUND: Duodenogastric reflux is believed to cause damage to gastric mucosa. Most reports on this disorder concern adult patients. PATIENTS AND METHODS: 1120 children with abdominal pain were studied; endoscopic features of duodenogastric reflux were found in 92 patients. To confirm the diagnosis of duodenogastric reflux, cholescintigraphy (Tc99-HEPIDA) was performed. Children with confirmed duodenogastric reflux by scintigraphy were given a prokinetic drug (cisapride). RESULTS: Endoscopic features of duodenogastric reflux were found in 92 children; the diagnosis was confirmed by scintigraphy in 59 patients. There was no significant difference in the severity of inflammation in gastric mucosa compared with the control group, whereas significantly fewer of these patients were infected with Helicobacter pylori. There was no correlation between regions of isotope accumulation and inflammatory lesions in the stomach. The prokinetic drug (cisapride) helped eliminate or greatly reduce duodenogastric reflux in children. CONCLUSIONS: When endoscopic features of duodenogastric reflux are found the final diagnosis should be based on an examination that does not itself influence the motility of the gastrointestinal tract: cholescintigraphy seems to be a useful method. However, because the use of milk as a test meal affects the scintigraphic image, there was no correlation between the area of isotope accumulation and the localisation of inflammatory lesions in the stomach. Duodenogastric reflux seems to be less important as a cause of inflammatory lesions than other factors (such as genetic predisposition, stress, etc). Prokinetic drugs have a beneficial influence on treatment results in children with inflammatory lesions of gastric mucosa with duodenogastric reflux. (+info)Identification and characterization of human cytchrome P450 (CYP) isoforms interacting with cisapride<...
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Cisapride
... cisapride", issued 1999-Sep-21 Maclennan S, Augood C, Cash-Gibson L, Logan S, Gilbert RE (April 2010). "Cisapride treatment for ... Cisapride is still available in the United States and Canada for use in animals, and is commonly prescribed by veterinarians to ... Cisapride has been used for the treatment of gastroesophageal reflux disease (GERD). There is no evidence it is effective for ... Cisapride is a gastroprokinetic agent, a drug that increases motility in the upper gastrointestinal tract. It acts directly as ...
Constipation
Cisapride is widely available in third world countries, but has been withdrawn in most of the west. It has not been shown to ... Aboumarzouk, Omar M; Agarwal, Trisha; Antakia, Ramez; Shariff, Umar; Nelson, Richard L (19 January 2011). "Cisapride for ...
Phenylpropanolamine
"Unsafe Drugs- nimesulide, Cisapride, Phenylpropanolamine Banned". 27 January 2011. "Madras High Court Revokes Ban on ...
Metoclopramide
... is a substituted benzamide; cisapride and mosapride are structurally related. Metoclopramide was first described ...
Grapefruit-drug interactions
Gross AS, Goh YD, Addison RS, Shenfield GM (April 1999). "Influence of grapefruit juice on cisapride pharmacokinetics". ... Examples of such known CYP3A4 inhibitors include cisapride (Propulsid), erythromycin, itraconazole (Sporanox), ketoconazole ( ...
Drug of last resort
... such as cisapride. Aminoglycosides - their use is extremely restricted due to risk of hearing loss and kidney damage; ... Cisapride - used for severe gastroesophageal reflux disease (GERD); carries risk of heart arrhythmias; Clomethiazole - a ...
Paracetamol
AUC increases are also observed with nizatidine and cisapride. The effect is explained by these drugs inhibiting ...
Diazepam
Cisapride may enhance the absorption, and therefore the sedative activity, of diazepam. Small doses of theophylline may inhibit ... Bateman DN (1986). "The action of cisapride on gastric emptying and the pharmacodynamics and pharmacokinetics of oral diazepam ...
Intestinal pseudo-obstruction
Prucalopride, pyridostigmine, metoclopramide, cisapride, erythromycin and octreotide are medications that aim to enhance ...
5-HT4 receptor
BIMU-8 Cisapride CJ-033,466 - partial agonist ML-10302 Mosapride Prucalopride Renzapride RS-67506 RS-67333 - partial agonist ... "Overexpression of serotonin4 receptors in cisapride-responsive adrenocorticotropin-independent bilateral macronodular adrenal ...
Prokinetic agent
As such, the relatively poor selectivity profile of cisapride versus other receptors (especially hERG [human ether-a-go-go K+] ... Some of these prokinetic agents, such as mosapride and cisapride, classic benzamides, have only moderate affinity for 5HT4 ... Benzamide Cisapride Domperidone Itopride Mosapride Metoclopramide Prucalopride Renzapride Tegaserod Mitemcinal Levosulpiride ...
Simeticone
"A randomized placebo-controlled trial of simethicone and cisapride for the treatment of patients with functional dyspepsia". ...
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Medical treatment with laxatives, enemas and prokinetic agents, such as cisapride, does not relieve the burdensome symptoms. ...
Serotonin receptor agonist
Cisapride and tegaserod are 5-HT4 receptor partial agonists that were used to treat disorders of gastrointestinal motility. ...
Mosapride
... drug information - Drugs Update India Kii Y, Ito T (May 1997). "Effects of 5-HT4-receptor agonists, cisapride, ...
CJ-033466
Toga T, Kohmura Y, Kawatsu R (October 2007). "The 5-HT(4) agonists cisapride, mosapride, and CJ-033466, a Novel potent compound ... In animal tests it stimulated gastrointestinal motility with 30 times the potency of cisapride, and with lower affinity for the ...
Itopride
The affinity of cisapride for 5-HT4 receptors in the heart has been implicated in the undesirable cardiac effects of cisapride ... Itopride belongs to the same benzamide group as cisapride, a drug found to affect QT interval and possibly predispose those ... Moreover, itopride has no affinity for the 5-HT4 receptors, unlike other benzamides such as cisapride and mosapride, which are ... unlike cisapride and mosapride, as it is metabolized by a different enzyme set. New molecular studies on guinea pig ventricular ...
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Erythromycin
Other examples include terfenadine (Seldane, Seldane-D), astemizole (Hismanal), cisapride (Propulsid, withdrawn in many ...
Velusetrag
... to earlier generation 5-HT agonists like cisapride and tegaserod. In a large clinical trial in patients with chronic idiopathic ...
5-HT3 antagonist
Certain prokinetic drugs such as cisapride, renzapride and metoclopramide, although not 5-HT3 antagonists proper, possess some ...
Chiral switch
... and cisapride to norcisapride. A summary is presented in the table below. Chiral drugs Chirality Enantiopure drug Chiral ...
Atazanavir
... cisapride, St. John's wort, lovastatin, simvastatin, sildenafil, indinavir, or nevirapine. Common side effects include: nausea ...
Sucralfate
... cisapride + sucralfate can significantly improve symptoms and quality of life and was more cost-effective than ranitidine ...
Ketoconazole
... cisapride, nisoldipine, dofetilide, pimozide And is not recommended: carbamazepine, phenytoin gastric acid suppressants: ...
Clarithromycin
... cisapride, pimozide, astemizole, terfenadine, ergotamine, ticagrelor, ranolazine or dihydroergotamine is not recommended. It ...
List of MeSH codes (D03)
... cisapride MeSH D03.383.621.147 - clopamide MeSH D03.383.621.160 - cyproheptadine MeSH D03.383.621.160.500 - loratadine MeSH ...
Prucalopride
... differs from other 5-HT4 agonists such as tegaserod and cisapride, which at therapeutic concentrations also ...
Parasympathomimetic drug
A Irreversible cholinesterase inhibitors Echothiophate Isoflurophate Malathion ACh release promoters Alpha GPC Cisapride ...
List of MeSH codes (D02)
... cisapride MeSH D02.065.277.194 - deet MeSH D02.065.277.225 - dinitolmide MeSH D02.065.277.431 - hippurates MeSH D02.065.277.431 ... cisapride MeSH D02.241.223.100.120.230 - deet MeSH D02.241.223.100.120.240 - dinitolmide MeSH D02.241.223.100.120.460 - ...
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Cisapride: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Cisapride comes as a tablet and liquid to take by mouth. Cisapride usually is taken four times a day, 15 minutes before meals ... Before taking cisapride,. *tell your doctor and pharmacist if you are allergic to cisapride or any other drugs. ... Take cisapride exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. ...
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Cisapride disposition in neonates and infants: in vivo reflection of cytochrome P450 3A4 ontogeny
... of cisapride CL/F in neonates and young infants was nonrenal in nature; (3) CL/F of cisapride in neonates and infants noted in ... 1) In neonates and infants, cisapride absorption and metabolism to its primary metabolite, norcisapride, were developmentally ... of cisapride CL/F in neonates and young infants was nonrenal in nature; (3) CL/F of cisapride in neonates and infants noted in ... Cisapride disposition in neonates and infants: in vivo reflection of cytochrome P450 3A4 ontogeny Clin Pharmacol Ther. 2003 Oct ...
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The risk of fatal arrhythmia with cisapride was believed to outweigh the benefit for the approved indication, treatme … ... Postmarketing reports and pharmacokinetic and electrophysiological data provided evidence that cisapride is associated with the ... Factors that suggested an association with cisapride included a temporal relationship between use of cisapride and arrhythmia, ... Results: While cisapride was being marketed from 1993-1999, the FDA received reports of the following patients: 117 who ...
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Appendix -- Characteristics of Available Antiretroviral Drugs
Indinavir is not recommended for concurrent use with antihistamines (e.g., astemizole or terfenadine); cisapride; ergot ... Nelfinavir is not recommended for concurrent use with antihistamines (e.g., astemizole or terfenadine); cisapride; ergot ... Saquinavir is not recommended for concurrent use with antihistamines (e.g., astemizole or terfenadine); cisapride; ergot ... cisapride; sedative-hypnotics (e.g., alprazolam, clorazepate, diazepam, estazolam, flurazepam hydrochloride, midazolam, ...
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Cisapride is a medication used to encourage normal emptying and forward motion of digestive contents. Learn more about how it ... What Does Cisapride Do For Cats?. Cisapride has been found to be useful in treating cats with recurrent constipation, and for ... Why is Cisapride Banned?. In people, cisapride was found to cause a certain type of heart rhythm disorder, or arrhythmia, ... About Cisapride For Cats. Cisapride is classified as a prokinetic or promotility agent. It is a serotonin (5-HT4)-receptor ...
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Indinavir is not recommended for concurrent use with antihistamines (e.g., astemizole or terfenadine); cisapride; ergot ... Nelfinavir is not recommended for concurrent use with antihistamines (e.g., astemizole or terfenadine); cisapride; ergot ... Saquinavir is not recommended for concurrent use with antihistamines (e.g., astemizole or terfenadine); cisapride; ergot ... cisapride; or warfarin. * DLV clearance is increased, resulting in substantially reduced concentrations of DLV, with concurrent ...
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Assessment of meal induced gastric accommodation by a satiety drinking test in health and in severe functional dyspepsia | Gut
Influence of cisapride on gastric tone and on the perception of gastric distension. Aliment Pharmacol Ther1998;12:761-6. ... Both sumatriptan and cisapride were shown to enhance accommodation to a meal, and erythromycin was shown to inhibit ... Cisapride significantly enhanced the amount of food ingested from 1444 (78) kcal (963 (52) ml) to 1684 (93) kcal (1123 (62) ml ... Tack J, Coremans G, Janssens J. A risk-benefit appraisal of cisapride in the treatment of gastrointestinal disorders. Drug Saf ...
PimozideAstemizolePropulsidMetoclopramideErythromycinMotilityGrapefruitMegacolonStimulatesProkineticSerious irregularRanitidineArrhythmiaPharmacokineticMedicationMedicationsInfantsNighttime heartburnDoctor or pharmacistAllergicPrecautionsPregnantDrugConstipationTreatmentsTabletsLiquid to take by mouthSideAssociationHelpsHeartTestsTotal
Pimozide3
- Biaxin may interact with cisapride, pimozide, ergot medicines and result in life-threatening heart rhythm disorders. (pcostracker.app)
- Concomitant administration of clarithromycin and any of the following drugs is contra-indicated: cisapride, pimozide and terfenadine. (nafarma.com)
- Elevated cisapride, pimozide and terfenadine levels have been reported in patients receiving either of these drugs and clarithromycin concomitantly. (nafarma.com)
Astemizole2
- Recognition and reporting of this arrhythmia in association with terfenadine, astemizole (Hismanal), cisapride (Propulsid), grepafloxacin (Raxar), and mibefradil (Posicor) ultimately led to the removal of these medications from the market. (fda.gov)
- Astemizole, terfenadine, and cisapride are no longer marketed in Canada. (medbroadcast.com)
Propulsid2
- Cisapride is sold under the brand name Propulsid, and it is used in the treatment of gastric reflux, which is usually experienced as heartburn. (medsol.info)
- Other medicines include metoclopramide (brand name: Reglan) and cisapride (brand name: Propulsid). (aafp.org)
Metoclopramide3
- Further medication included propulsive agents (metoclopramide 20 mgs i.v. every 6 h, cisapride 10 cc p.o. every 6 h) and immunosuppression (tacrolimus 0.05 mgs/kg or cyclosporine 4 mgs/kg, ATG 5 mgs/kg, prednisolone 20 mgs/day, mycophenolatmofetile 2 g/day). (biomedcentral.com)
- Certain medicines should not be taken while taking metoclopramide and cisapride. (aafp.org)
- Metoclopramide, cisapride may decrease the inhibitory effect of the drug Scopolan on the digestive tract. (herbapol.pl)
Erythromycin1
- Pharmacological agents (sumatriptan, cisapride, erythromycin) affected the satiety test according to their effect on accommodation. (bmj.com)
Motility3
- Cisapride increases GI motility by enhancing the release of acetylcholine at the myenteric plexuses in the gut plain muscle. (mims.com)
- Effects of ranitidine and cisapride on acid reflux and oesophageal motility in patients with reflux oesophagitis: a 24 hour ambulatory combined pH and manometry study. (mcmaster.ca)
- Because cisapride stimulates motility and pushes digestive contents along, it is extremely important that the medication is only used in the absence of a current obstruction. (allaboutcats.com)
Grapefruit2
- Do not drink grapefruit juice while taking cisapride. (medlineplus.gov)
- Grapefruit juice increases bioavailability of cisapride, avoid concomitant use. (mims.com)
Megacolon2
- Cisapride has been found to be useful in treating cats with recurrent constipation, and for cats with megacolon. (allaboutcats.com)
- Megacolon can be reversed with cisapride and an enema. (veterinarypracticenews.com)
Stimulates1
- Medications such as cisapride, which stimulates the gut to move, can be helpful. (vethelpdirect.com)
Prokinetic2
- Cisapride, a prokinetic agent and substrate for cytochrome P450 (CYP) 3A4, has been used to treat neonates and infants with feeding intolerance and apnea or bradycardia associated with gastroesophageal reflux. (nih.gov)
- Cisapride is classified as a prokinetic or promotility agent. (allaboutcats.com)
Serious irregular2
- Cisapride may cause serious irregular heart beats, which can lead to death. (medlineplus.gov)
- Cisapride may cause some other serious irregular symptoms. (medsol.info)
Ranitidine1
- Cisapride increases the GI absorption of cimetidine and ranitidine. (mims.com)
Arrhythmia4
- The FDA analyzed reports of patients who developed QT prolongation, torsades de pointes, and ventricular arrhythmia in association with the use of cisapride to assess probable etiology and risk factors. (nih.gov)
- Factors that suggested an association with cisapride included a temporal relationship between use of cisapride and arrhythmia, the absence of identified risk factors and other explanations for arrhythmia in some patients, and cases of positive dechallenge and rechallenge. (nih.gov)
- The risk of fatal arrhythmia with cisapride was believed to outweigh the benefit for the approved indication, treatment of nocturnal heartburn due to gastroesophageal reflux disease, leading to the drug's discontinuation in the United States. (nih.gov)
- In people , cisapride was found to lead to a certain abnormal heart rhythm, or arrhythmia, prompting it to be removed as a drug for human use. (allaboutcats.com)
Pharmacokinetic3
- This known developmental delay in the expression of CYP3A4 prompted us to conduct a classical open-label pharmacokinetic study of cisapride in neonates and young infants. (nih.gov)
- Cisapride and norcisapride were quantitated from plasma by HPLC-tandem mass spectrometry and pharmacokinetic data determined (n = 32) by noncompartmental methods. (nih.gov)
- Postmarketing reports and pharmacokinetic and electrophysiological data provided evidence that cisapride is associated with the occurrence of QT prolongation and torsades de pointes. (nih.gov)
Medication9
- Cisapride can also be used for some other purposes that are not mentioned in this document or in this medication guide. (medsol.info)
- Whether you are taking cisapride or not, always talk to your doctor or pharmacist first about this medication. (medsol.info)
- Your healthcare professionals will check your body's response towards this medication through some lab tests and don't ever try to take less or more of cisapride than prescribed by your healthcare professionals. (medsol.info)
- Ask your doctor or pharmacist for more information about the prescribed treatments for other diseases of cisapride medication because cisapride should not be prescribed for other uses. (medsol.info)
- This medication only uses serious side effects because people that are using cisapride medication have some serious side effects. (medsol.info)
- Don't use this medication without your doctor's prescription, Doctors will suggest cisapride medication by judging the benefit to you is greater than the risk of side effects. (medsol.info)
- Cisapride is a promotility agent, or a medication that is used to encourage normal emptying and forward motion of digestive contents out of the stomach and through the gastrointestinal tract. (allaboutcats.com)
- Cisapride is only available as a compounded medication, allowing for many different dosage sizes or liquid concentrations based on a prescribing veterinarian's instructions. (allaboutcats.com)
- Cisapride is not a commercially available medication . (allaboutcats.com)
Medications2
- Lastly, cisapride can have drug interactions with several other types of medications. (allaboutcats.com)
- Always make sure to discuss any medications your cat is currently on with your vet before starting cisapride. (allaboutcats.com)
Infants4
- A total of 35 infants with a postconceptional age of 28 to 54 weeks at the time of the study received a single oral cisapride dose (0.2 mg/kg) at a postnatal age of 4 to 102 days, followed by repeated (n = 7) blood sampling over a 24-hour period. (nih.gov)
- The apparent renal clearance (CL(R)) of cisapride in infants (n = 28) was estimated to be 0.003 +/- 0.003 L. h(-1). (nih.gov)
- All infants tolerated a single dose of cisapride well without significant alteration in QTc. (nih.gov)
- QTc interval in infants receiving cisapride. (bvsalud.org)
Nighttime heartburn1
- Cisapride is used to treat symptoms of nighttime heartburn in people who have not responded to other treatments. (medlineplus.gov)
Doctor or pharmacist1
- Talk to your doctor or pharmacist about whether you should be taking cisapride. (medlineplus.gov)
Allergic2
- tell your doctor and pharmacist if you are allergic to cisapride or any other drugs. (medlineplus.gov)
- Cisapride is not used by the people who are allergic to it, or if you have bleeding or an obstruction in your stomach, heart disease or hardening of the arteries, a heart rhythm disorder. (medsol.info)
Precautions1
- What is Cisapride medicine uses, side effects & precautions? (medsol.info)
Pregnant2
- If you become pregnant while taking cisapride, call your doctor. (medlineplus.gov)
- Cisapride should be used very cautiously in pregnant or nursing queens. (allaboutcats.com)
Drug1
- To describe the postmarketing safety data used in the risk assessment of cisapride and to summarize the regulatory actions of the Food and Drug Administration (FDA). (nih.gov)
Constipation2
- By stimulating smooth muscle in the colon wall, cisapride helps the colon to move feces out and keeps it from backing up and leading to further constipation or obstipation. (allaboutcats.com)
- Cisapride should also be used cautiously in pets that suffer from constipation, have liver disease, or any signs of bleeding from the digestive tract. (allaboutcats.com)
Treatments1
- For treatment of this symptom, cisapride is used for those who have not responded to other treatments. (medsol.info)
Tablets1
- Cisapride is available in both forms tablets or liquid to take by mouth. (medsol.info)
Liquid to take by mouth1
- Cisapride comes as a tablet and liquid to take by mouth. (medlineplus.gov)
Side2
- Cisapride may cause side effects. (medlineplus.gov)
- In this article, you'll learn more about how cisapride works, how it is prescribed, potential side effects, and some frequently asked questions. (allaboutcats.com)
Association1
- 001, r(2) = 0.47) but not with CL/F. For norcisapride, the mean apparent C(max) was highest and the t(max) was shortest in the oldest postconceptional age group, although no association between postconceptional age and the norcisapride/cisapride area under the curve ratio was observed. (nih.gov)
Helps1
- Cisapride helps in increasing the digestion rate at which your esophagus, stomach, and intestines move. (medsol.info)
Heart1
- All the same, any cats with pre-existing heart disease may benefit from regular screening of their heart rate and rhythm while on cisapride. (allaboutcats.com)
Tests1
- Your doctor will order certain lab tests to check your body's response to cisapride. (medlineplus.gov)
Total1
- for a total of 341 individual patients affected, following use of cisapride. (nih.gov)