AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaTechnology, Industry, AgricultureInformation ScienceHealth Care
CisaprideDigestive System Physiological PhenomenaDigestionDigestive SystemGastrointestinal AgentsPasteurellosis, PneumonicShipsFatigue Syndrome, ChronicPleurodynia, EpidemicBipolar DisorderAttention Deficit Disorder with HyperactivityGastroesophageal RefluxAmyotrophic Lateral SclerosisParasympathomimeticsAcetylcholineUpper Gastrointestinal TractEnteric Nervous SystemBenzyl CompoundsDancingOnionsNaval MedicineDiagnosis, OralChronology as TopicSleep DeprivationAmbulatory Surgical ProceduresGastric EmptyingStomachSurgicentersGastric BalloonGastroparesisTabletsInterstitial Cells of CajalXylansCellulosePiperidinesChromatography, High Pressure LiquidIntestinal Pseudo-ObstructionEsophagogastric JunctionManometryGastrointestinal TransitColonic Pseudo-ObstructionProduct Surveillance, PostmarketingTorsades de PointesAdverse Drug Reaction Reporting SystemsLong QT SyndromeDeductibles and CoinsuranceUnited States Food and Drug AdministrationEmergency Service, HospitalEmergenciesInternetEmergency MedicineEmergency Treatment
Cisapride
A substituted benzamide used for its prokinetic properties. It is used in the management of gastroesophageal reflux disease, functional dyspepsia, and other disorders associated with impaired gastrointestinal motility. (Martindale The Extra Pharmacopoeia, 31st ed)
Digestive System Physiological Phenomena
Properties and processes of the DIGESTIVE SYSTEM as a whole or of any of its parts.
Digestion
The process of breakdown of food for metabolism and use by the body.
Digestive System
A group of organs stretching from the MOUTH to the ANUS, serving to breakdown foods, assimilate nutrients, and eliminate waste. In humans, the digestive system includes the GASTROINTESTINAL TRACT and the accessory glands (LIVER; BILIARY TRACT; PANCREAS).
Gastrointestinal Agents
Drugs used for their effects on the gastrointestinal system, as to control gastric acidity, regulate gastrointestinal motility and water flow, and improve digestion.
Pasteurellosis, Pneumonic
Bovine respiratory disease found in animals that have been shipped or exposed to CATTLE recently transported. The major agent responsible for the disease is MANNHEIMIA HAEMOLYTICA and less commonly, PASTEURELLA MULTOCIDA or HAEMOPHILUS SOMNUS. All three agents are normal inhabitants of the bovine nasal pharyngeal mucosa but not the LUNG. They are considered opportunistic pathogens following STRESS, PHYSIOLOGICAL and/or a viral infection. The resulting bacterial fibrinous BRONCHOPNEUMONIA is often fatal.
Ships
Large vessels propelled by power or sail used for transportation on rivers, seas, oceans, or other navigable waters. Boats are smaller vessels propelled by oars, paddles, sail, or power; they may or may not have a deck.
Fatigue Syndrome, Chronic
A syndrome characterized by persistent or recurrent fatigue, diffuse musculoskeletal pain, sleep disturbances, and subjective cognitive impairment of 6 months duration or longer. Symptoms are not caused by ongoing exertion; are not relieved by rest; and result in a substantial reduction of previous levels of occupational, educational, social, or personal activities. Minor alterations of immune, neuroendocrine, and autonomic function may be associated with this syndrome. There is also considerable overlap between this condition and FIBROMYALGIA. (From Semin Neurol 1998;18(2):237-42; Ann Intern Med 1994 Dec 15;121(12): 953-9)
Pleurodynia, Epidemic
An acute, febrile, infectious disease generally occurring in epidemics. It is usually caused by coxsackieviruses B and sometimes by coxsackieviruses A; echoviruses; or other enteroviruses.
Bipolar Disorder
A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence.
Attention Deficit Disorder with Hyperactivity
A behavior disorder originating in childhood in which the essential features are signs of developmentally inappropriate inattention, impulsivity, and hyperactivity. Although most individuals have symptoms of both inattention and hyperactivity-impulsivity, one or the other pattern may be predominant. The disorder is more frequent in males than females. Onset is in childhood. Symptoms often attenuate during late adolescence although a minority experience the full complement of symptoms into mid-adulthood. (From DSM-V)
Gastroesophageal Reflux
Retrograde flow of gastric juice (GASTRIC ACID) and/or duodenal contents (BILE ACIDS; PANCREATIC JUICE) into the distal ESOPHAGUS, commonly due to incompetence of the LOWER ESOPHAGEAL SPHINCTER.
Amyotrophic Lateral Sclerosis
A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
Parasympathomimetics
Drugs that mimic the effects of parasympathetic nervous system activity. Included here are drugs that directly stimulate muscarinic receptors and drugs that potentiate cholinergic activity, usually by slowing the breakdown of acetylcholine (CHOLINESTERASE INHIBITORS). Drugs that stimulate both sympathetic and parasympathetic postganglionic neurons (GANGLIONIC STIMULANTS) are not included here.
Acetylcholine
A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system.
Upper Gastrointestinal Tract
The segment of GASTROINTESTINAL TRACT that includes the ESOPHAGUS; the STOMACH; and the DUODENUM.
Enteric Nervous System
Two ganglionated neural plexuses in the gut wall which form one of the three major divisions of the autonomic nervous system. The enteric nervous system innervates the gastrointestinal tract, the pancreas, and the gallbladder. It contains sensory neurons, interneurons, and motor neurons. Thus the circuitry can autonomously sense the tension and the chemical environment in the gut and regulate blood vessel tone, motility, secretions, and fluid transport. The system is itself governed by the central nervous system and receives both parasympathetic and sympathetic innervation. (From Kandel, Schwartz, and Jessel, Principles of Neural Science, 3d ed, p766)
Benzyl Compounds
Dancing
Rhythmic and patterned body movements which are usually performed to music.
Onions
Herbaceous biennial plants and their edible bulbs, belonging to the Liliaceae.
Naval Medicine
The practice of medicine concerned with conditions affecting the health of individuals associated with the marine environment.
Diagnosis, Oral
Examination of the mouth and teeth toward the identification and diagnosis of intraoral disease or manifestation of non-oral conditions.
Chronology as Topic
The temporal sequence of events that have occurred.
Sleep Deprivation
The state of being deprived of sleep under experimental conditions, due to life events, or from a wide variety of pathophysiologic causes such as medication effect, chronic illness, psychiatric illness, or sleep disorder.
Ambulatory Surgical Procedures
Surgery performed on an outpatient basis. It may be hospital-based or performed in an office or surgicenter.
Gastric Emptying
The evacuation of food from the stomach into the duodenum.
Stomach
An organ of digestion situated in the left upper quadrant of the abdomen between the termination of the ESOPHAGUS and the beginning of the DUODENUM.
Surgicenters
Facilities designed to serve patients who require surgical treatment exceeding the capabilities of usual physician's office yet not of such proportion as to require hospitalization.
Gastric Balloon
An inflatable device implanted in the stomach as an adjunct to therapy of morbid obesity. Specific types include the silicone Garren-Edwards Gastric Bubble (GEGB), approved by the FDA in 1985, and the Ballobes Balloon.
Gastroparesis
Chronic delayed gastric emptying. Gastroparesis may be caused by motor dysfunction or paralysis of STOMACH muscles or may be associated with other systemic diseases such as DIABETES MELLITUS.
Tablets
Solid dosage forms, of varying weight, size, and shape, which may be molded or compressed, and which contain a medicinal substance in pure or diluted form. (Dorland, 28th ed)
Interstitial Cells of Cajal
c-Kit positive cells related to SMOOTH MUSCLE CELLS that are intercalated between the autonomic nerves and the effector smooth muscle cells of the GASTROINTESTINAL TRACT. Different phenotypic classes play roles as pacemakers, mediators of neural inputs, and mechanosensors.
Xylans
Polysaccharides consisting of xylose units.
Cellulose
A polysaccharide with glucose units linked as in CELLOBIOSE. It is the chief constituent of plant fibers, cotton being the purest natural form of the substance. As a raw material, it forms the basis for many derivatives used in chromatography, ion exchange materials, explosives manufacturing, and pharmaceutical preparations.
Piperidines
A family of hexahydropyridines.
Chromatography, High Pressure Liquid
Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.
Intestinal Pseudo-Obstruction
A type of ILEUS, a functional not mechanical obstruction of the INTESTINES. This syndrome is caused by a large number of disorders involving the smooth muscles (MUSCLE, SMOOTH) or the NERVOUS SYSTEM.
Esophagogastric Junction
The area covering the terminal portion of ESOPHAGUS and the beginning of STOMACH at the cardiac orifice.
Manometry
Measurement of the pressure or tension of liquids or gases with a manometer.
Gastrointestinal Transit
Passage of food (sometimes in the form of a test meal) through the gastrointestinal tract as measured in minutes or hours. The rate of passage through the intestine is an indicator of small bowel function.
Colonic Pseudo-Obstruction
Functional obstruction of the COLON leading to MEGACOLON in the absence of obvious COLONIC DISEASES or mechanical obstruction. When this condition is acquired, acute, and coexisting with another medical condition (trauma, surgery, serious injuries or illness, or medication), it is called Ogilvie's syndrome.
Product Surveillance, Postmarketing
Surveillance of drugs, devices, appliances, etc., for efficacy or adverse effects, after they have been released for general sale.
Torsades de Pointes
A malignant form of polymorphic ventricular tachycardia that is characterized by HEART RATE between 200 and 250 beats per minute, and QRS complexes with changing amplitude and twisting of the points. The term also describes the syndrome of tachycardia with prolonged ventricular repolarization, long QT intervals exceeding 500 milliseconds or BRADYCARDIA. Torsades de pointes may be self-limited or may progress to VENTRICULAR FIBRILLATION.
Adverse Drug Reaction Reporting Systems
Systems developed for collecting reports from government agencies, manufacturers, hospitals, physicians, and other sources on adverse drug reactions.
Long QT Syndrome
A condition that is characterized by episodes of fainting (SYNCOPE) and varying degree of ventricular arrhythmia as indicated by the prolonged QT interval. The inherited forms are caused by mutation of genes encoding cardiac ion channel proteins. The two major forms are ROMANO-WARD SYNDROME and JERVELL-LANGE NIELSEN SYNDROME.
Deductibles and Coinsurance
Cost-sharing mechanisms that provide for payment by the insured of some portion of covered expenses. Deductibles are the amounts paid by the insured under a health insurance contract before benefits become payable; coinsurance is the provision under which the insured pays part of the medical bill, usually according to a fixed percentage, when benefits become payable.
United States Food and Drug Administration
An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.
Emergency Service, Hospital
Hospital department responsible for the administration and provision of immediate medical or surgical care to the emergency patient.
Emergencies
Situations or conditions requiring immediate intervention to avoid serious adverse results.
Internet
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
Emergency Medicine
The branch of medicine concerned with the evaluation and initial treatment of urgent and emergent medical problems, such as those caused by accidents, trauma, sudden illness, poisoning, or disasters. Emergency medical care can be provided at the hospital or at sites outside the medical facility.
Emergency Treatment
First aid or other immediate intervention for accidents or medical conditions requiring immediate care and treatment before definitive medical and surgical management can be procured.

Delayed gastric emptying after Billroth I pylorus-preserving pancreatoduodenectomy: effect of postoperative time and cisapride. (1/188)

OBJECTIVE: To study the recovery course of gastric emptying after Billroth I pylorus-preserving pancreatoduodenectomy (PPPD) and therapeutic effects of cisapride. METHODS: To examine gastric emptying, acetaminophen was given, admixed in a pasty liquid meal, to 16 patients undergoing PPPD before surgery and at 1, 3, 6, 9, and 12 months after surgery. Cisapride was given orally to 10 patients before they received the acetaminophen regimen. Electrogastrography was performed at 2 weeks to 1 month after surgery in eight patients and at 6 to 12 months after surgery in seven patients. RESULTS: Gastric emptying was delayed but returned to the preoperative level by 6 months after surgery. Pretreatment with cisapride accelerated gastric emptying during months 1 to 6 but not during months 6 to 12 after surgery. Electrogastrography frequently showed tachygastria 2 weeks to 1 month after surgery, but seldom 6 to 12 months after surgery. CONCLUSIONS: After Billroth I PPPD, gastric emptying is delayed but recovers by 6 months after surgery. Tachygastria may play a part in the pathogenesis of delayed gastric emptying, but it can be treated with cisapride.  (+info)

Intestinal prokinesia by two esters of 4-amino-5-chloro-2- methoxybenzoic acid: involvement of 5-hydroxytryptamine-4 receptors and dissociation from cardiac effects in vivo. (2/188)

In five fasting, conscious dogs, we compared the prokinetic action of two selective 5-hydroxytryptamine-4 (5-HT4) receptor agonists with low affinity for 5-HT3 receptors ML10302 (2-piperidinoethyl 4-amino-5-chloro-2-methoxybenzoate) and SR59768 (2-[(3S)-3-hydroxypiperidino]ethyl 4-amino-5-chloro-2-methoxybenzoate) in the duodenum and jejunum, using cisapride as a reference compound. Heart rate and rate-corrected QT (QTc) also were monitored to assess whether or not the cardiac effects of cisapride are shared by other 5-HT4 receptor agonists. Both ML10302 and SR59768 dose-dependently stimulated spike activity in the duodenum with similar potencies (dose range, 3-300 nmol/kg i.v.; ED50 values: 24 and 23 nmol/kg i.v., respectively), mimicking the effect of cisapride (30-3000 nmol/kg i.v.). The maximal effect was achieved with the dose of 100 nmol/kg i.v. for both compounds. Similar findings were obtained in the jejunum. Atropine and GR125487 (1-[2-[(methylsulfonyl)amino]ethyl]-4-piperidinyl-methyl 5-fluoro-2-methoxy-1H-indole-3-carboxylate, selective 5-HT4 receptor antagonist), at doses having no effect per se, antagonized intestinal prokinesia by maximal doses of ML10302 and SR59768. Neither ML10302 nor SR59768 had any effect on heart rate or QTc at any of the doses tested, whereas cisapride, at the highest dose (3000 nmol/kg), induced tachycardia and lengthened the QTC (p <.01). In conclusion, ML10302 and SR59768 share with cisapride a similar prokinetic action in the canine duodenum and jejunum in vivo. This effect is mediated by pathways involving activation of 5-HT4 and muscarinic receptors. Unlike cisapride, which induces tachycardia and prolongs the QTc by a mechanism probably unrelated to 5-HT4 receptor activation, ML10302 and SR59768 are devoid of cardiac effects in this model.  (+info)

A simple high-performance liquid chromatography assay for the major cisapride metabolite, norcisapride, in human urine. (3/188)

A simple high-performance liquid chromatography assay using fluorescence detection for the major metabolite of the gastric prokinetic drug cisapride, norcisapride, is presented. Analysis is performed using an Alltech Platinum EPS C8 column with a mobile phase made up of methanol and 0.02M sodium dihygrogen phosphate (45:55, v/v) containing triethylamine (1 g/L). Complete resolution is achieved among norcisapride, the internal standard (metoclopramide), and endogenous urinary components. The assay is linear over the range 50-2000 ng/mL with a mean recovery of 71.2% across the analytical range following solvent extraction with toluene-isoamyl alcohol (95:5, v/v). Intraday coefficients of variation (precision) determined at 200 and 1000 ng/mL are 6.0 and 9.8%, respectively, and interday coefficients of variation are 8.8 and 6.6%, respectively. Intra- and interassay accuracy (as mean relative error) determined at the same concentrations is within 10% in all cases. An analysis of urine samples from a healthy volunteer following the administration of a single 10-mg oral dose of cisapride is shown.  (+info)

Clinical considerations in GERD (gastroesophageal reflux disease) therapy: focus on cisapride. (4/188)

Heartburn, the major symptom of gastrointestinal reflux disease (GERD), is a common condition that is usually self-treated with over-the-counter products. For patients with severe or recurrent symptoms of GERD, pharmacologic therapy includes acid suppression with H2-receptor antagonists and proton pump inhibitors, and, alternatively, the use of prokinetic agents. While all of these are efficacious, given its high efficacy in nonerosive and mild-to-moderate erosive esophagitis, the prokinetic agent cisapride deserves significant consideration in this patient population.  (+info)

Identification of SK-951, a novel benzofuran derivative, as an agonist to 5-HT4 receptors. (5/188)

The pharmacological profile of SK-951 ((-)4-amino-N-[2-(1-azabicyclo[3.3.0]octan-5-yl) ethyl]-5-chloro-2,3-dihydro-2-methylbenzo[b]furan-7-carboxamide hemifumarate) was identified in relation to serotonin 5-HT3 and 5-HT4 receptors by the receptor binding assay and functional studies. The receptor binding assay showed that SK-951 bound to the 5-HT3 receptor with a high affinity, to the 5-HT4 receptor with relatively higher affinity and to the muscarinic M2 receptor with a low affinity, but not to dopamine D1 and D2 and serotonin 5-HT1 and 5-HT2 and muscarinic M1 and M3 receptors. SK-951 caused relaxations of tunica muscularis mucosae preparations from rat esophagus which were precontracted with carbachol, and the effects were antagonized by GR113808, a selective 5-HT4 antagonist. In the longitudinal muscle with myenteric plexus (LMMP) preparations from guinea pig ileum, SK-951 enhanced the electrically-stimulated contraction of preparations in which the 5-HT1, 5-HT2 and 5-HT3 receptors were blocked, and it enhanced the electrically-stimulated release of [3H]acetylcholine (ACh). These effects of SK-951 were antagonized by GR113808. SK-951 inhibited the 5-HT3 receptor-mediated contractions. These results indicate that SK-951 possesses properties of an agonist for the 5-HT4 receptor and an antagonist for the 5-HT3 receptor. Thus, SK-951 is a new and potent 5-HT4-receptor agonist and causes contractions of guinea pig ileum mediated by enhancement of ACh release via the 5-HT4 receptor.  (+info)

Randomised controlled trial of cisapride in preterm infants. (6/188)

AIM: To determine the effect of cisapride on gastrointestinal motility in preterm infants. METHODS: Cisapride (0.2 mg/kg, 8 hourly ) or placebo was given first for seven days in a double blind randomised crossover study of 10 preterm infants. Gastrointestinal motility was assessed on day 3 of each treatment. The half gastric emptying time (GET1/2) was determined by using ultrasonography to measure the decrease in the gastric antral cross sectional area after a feed. The whole gastrointestinal transit time (WGTT) was assessed by timing the transit of carmine red through the gut. Treatments were compared using the Wilcoxon matched pairs signed ranks test. RESULTS: Median (range) birthweight was 1200 (620, 1450) g and postconceptional age 33 (29, 34) weeks at recruitment. GET1/2 was significantly longer during cisapride treatment than during placebo; the median of the differences (95% confidence interval) was 19.2 (11, 30 minutes, p=0.008). WGTT was also longer during cisapride treatment, but the difference was not significant; the median of the differences was 11(-18, 52 hours, p=0.1). CONCLUSIONS: Cisapride delays gastric emptying and may delay WGTT in preterm infants. Its use to promote gastrointestinal motility in this group cannot be recommended.  (+info)

The effect of cisapride on duodenal acid exposure in the proximal duodenum in healthy subjects. (7/188)

AIM: To investigate the effect of the prokinetic drug, cisapride, on fasting and postprandial acid exposure in the proximal duodenum. METHODS: Using a double-blind, placebo-controlled crossover study design, 12 healthy male volunteers were studied. After 1 week of dosing (cisapride 20 mg b.d. orally or placebo), fasting and postprandial antroduodenal pH-and pressure-recordings were made. Using a small-caliber (4 mm) catheter, containing one antral and two duodenal pH electrodes, and two antral and three duodenal pressure recording sites. Transmucosal potential difference was measured to ensure proper catheter position. Infusions of 0.1 N HCl were given in the duodenal bulb. RESULTS: Endogenous acidification of the duodenal bulb occurred more frequently during phase II and postprandially, compared to phase I (P<0.001). During phase I, alkalinization of the antrum was observed. Cisapride significantly increased the postprandial number of duodenal acidic periods (P<0.02), but shortened their duration (P<0.04). The duodenal motor response elicited by exogenous acid was lower during phase I (P<0.05). CONCLUSIONS: Antral and proximal duodenal acidity vary with the phases of the interdigestive motor complex. Cisapride shortens the individual periods of duodenal acidification.  (+info)

Duodenogastric reflux: clinical and therapeutic aspects. (8/188)

BACKGROUND: Duodenogastric reflux is believed to cause damage to gastric mucosa. Most reports on this disorder concern adult patients. PATIENTS AND METHODS: 1120 children with abdominal pain were studied; endoscopic features of duodenogastric reflux were found in 92 patients. To confirm the diagnosis of duodenogastric reflux, cholescintigraphy (Tc99-HEPIDA) was performed. Children with confirmed duodenogastric reflux by scintigraphy were given a prokinetic drug (cisapride). RESULTS: Endoscopic features of duodenogastric reflux were found in 92 children; the diagnosis was confirmed by scintigraphy in 59 patients. There was no significant difference in the severity of inflammation in gastric mucosa compared with the control group, whereas significantly fewer of these patients were infected with Helicobacter pylori. There was no correlation between regions of isotope accumulation and inflammatory lesions in the stomach. The prokinetic drug (cisapride) helped eliminate or greatly reduce duodenogastric reflux in children. CONCLUSIONS: When endoscopic features of duodenogastric reflux are found the final diagnosis should be based on an examination that does not itself influence the motility of the gastrointestinal tract: cholescintigraphy seems to be a useful method. However, because the use of milk as a test meal affects the scintigraphic image, there was no correlation between the area of isotope accumulation and the localisation of inflammatory lesions in the stomach. Duodenogastric reflux seems to be less important as a cause of inflammatory lesions than other factors (such as genetic predisposition, stress, etc). Prokinetic drugs have a beneficial influence on treatment results in children with inflammatory lesions of gastric mucosa with duodenogastric reflux.  (+info)

Identification and characterization of human cytchrome P450 (CYP) isoforms interacting with cisapride<...Identification and characterization of human cytchrome P450 (CYP) isoforms interacting with cisapride<...
TY - JOUR. T1 - Identification and characterization of human cytchrome P450 (CYP) isoforms interacting with cisapride. AU - Desta, Zeruesenay. AU - Thacker, David. AU - Soukhova, Nadia. AU - Shin, Jae Gook. AU - Flockhart, David A.. PY - 1999/1/1. Y1 - 1999/1/1. N2 - Using human liver microsomes (HLMs) and recombinant CYP450s, we characterized the metabolism of cisapride and documented its inhibitory effect on CYP450s. Two cisapride enantiomers (EI and EII) were separated and fractions collected for study. HPLC chromatograms of HLM incubates of cisapride separated 3 metabolite peaks, M1-M3. The identity of M1 is consistent with norcisapride, while M2 and M3 may represent oxidative hydroxylation of the fluorophenyl ring. The formation rate of M1 and 10μM cisapride in 15 HLMs significantly correlated with the activities of CYP3A, 2C19 and 1A2. Of CYP isoform specific inhibitors tested, ketoconazole potently inhibited the formation of M1, M2 and M3. Of the 10 recombinant CYP450s tested, CYP3A4, ...
https://indiana.pure.elsevier.com/en/publications/identification-and-characterization-of-human-cytchrome-p450-cyp-i
Cisapride + methylpolysiloxane : usage, side effects, expert advice and cisapride + methylpolysiloxane based medicines | 1mgCisapride + methylpolysiloxane : usage, side effects, expert advice and cisapride + methylpolysiloxane based medicines | 1mg
Cisapride + methylpolysiloxane is used in the treatment of .get complete information about cisapride + methylpolysiloxane including usage, side effects, drug interaction, expert advice along with medicines associated with cisapride + methylpolysiloxane at 1mg.com
https://www.1mg.com/generics/cisapride-methylpolysiloxane-401074
Mechanism of the acetylcholine-release effect of cisapride on guinea-pig gastrointestinal tract<...Mechanism of the acetylcholine-release effect of cisapride on guinea-pig gastrointestinal tract<...
TY - JOUR. T1 - Mechanism of the acetylcholine-release effect of cisapride on guinea-pig gastrointestinal tract. AU - Chen, H. T.. AU - Pan, S.. PY - 1988/1/1. Y1 - 1988/1/1. UR - http://www.scopus.com/inward/record.url?scp=0023689373&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0023689373&partnerID=8YFLogxK. M3 - Article. C2 - 3179814. AN - SCOPUS:0023689373. VL - 41. SP - 263. EP - 270. JO - Journal of the Chinese Medical Association. JF - Journal of the Chinese Medical Association. SN - 1726-4901. IS - 4. ER - ...
https://tmu.pure.elsevier.com/en/publications/mechanism-of-the-acetylcholine-release-effect-of-cisapride-on-gui
Phenomenex HPLC Application #20243: Cisapride on Lux 5µm Cellulose-2 in RPPhenomenex HPLC Application #20243: Cisapride on Lux 5µm Cellulose-2 in RP
HPLC Application #20243: Cisapride on Lux 5µm Cellulose-2 in RP. Column used: Lux® 5 µm Cellulose-2, LC Column 250 x 4.6 mm, Ea Part#: 00G-4457-E0
https://www.phenomenex.com/Application/Detail/20243
CredibleMeds :: CisaprideCredibleMeds :: Cisapride
Updated April 12, 2000. Since 1995 several labeling changes for cisapride (Propulsid, Janssen Pharmaceutica) have been required by the Food and Drug Administration (FDA) following serious adverse effects that were reported through the MedWatch reporting program.56 This system is in place to ensure that new safety information is rapidly communicated to the health care field in order to improve patient care. During post-marketing surveillance, cisapride has been associated with prolongation of the QT interval on the electrocardiogram (ECG).4,7,16,56Subsequently, cisapride was associated with the potentially fatal arrhythmia torsades de pointes when taken with certain medications or in patients who have certain underlying conditions predisposing them to arrhythmias.7,14,34,50,55,56. A recent FDA analysis of 270 adverse event reports (including 70 fatalities) revealed that approximately 85% of these cases occurred in patients with identifiable risks such as drug-QTDrug interactions and underlying ...
https://www.crediblemeds.org/everyone/interaction-advisory/cisapride/
Cisapride does not alter gastric volume or pH in patients undergoing ambulatory surgery.Cisapride does not alter gastric volume or pH in patients undergoing ambulatory surgery.
PURPOSE: To evaluate the efficacy of 20 mg cisapride p.o. in reducing residual gastric volume and pH in adult ambulatory surgical patients. METHODS: Using a prospective randomised double-blind controlled design, we administered either 20 mg cisapride
http://www.biomedsearch.com/nih/Cisapride-does-not-alter-gastric/10608215.html
What is cisapride? | Technology TrendsWhat is cisapride? | Technology Trends
Cisapride is a gastroprokinetic agent, a drug which increases motility in the upper gastrointestinal tract. It acts directly as a serotonin 5-HT4 receptor agonist and indirectly as a parasympathomimetic. Stimulation of the serotonin receptors increases acetylcholine release in the enteric nervous system. It has been sold under the trade names Prepulsid (Janssen-Ortho) and Propulsid (in the U.S.). It was discovered by Janssen Pharmaceutica in 1980. In many countries, it has been either withdrawn from the market or had its indications limited because of side effects.. Read more about Cisapride. ...
https://www.primidi.com/what_is_cisapride
Cisapride | Project Gutenberg Self-Publishing - eBooks | Read eBooks onlineCisapride | Project Gutenberg Self-Publishing - eBooks | Read eBooks online
Cisapride: | | Cisapride | | | ||| | | | ... World Heritage Encyclopedia, the aggregation of the largest online encyclopedias available, and the most definitive collection ever assembled.
http://self.gutenberg.org/articles/eng/Cisapride
Cisapride Compounded - 1800PetMedsCisapride Compounded - 1800PetMeds
Buy Cisapride Compounded medication online at 1800PetMeds to help speed up your pets digestive process. Get free shipping on all orders more than $49.
https://www.1800petmeds.com/Cisapride+Compounded-prod90015.html
PCTs will check GP records before transfer | News Article | Pulse TodayPCTs will check GP records before transfer | News Article | Pulse Today
The addition of an H2RA to twice-daily PPI has been shown to be helpful, although loss of effect with time (tachyphylaxis) has been reported with H2RAs.. Combination therapy of prokinetics, such as cisapride, with acid suppressants has been shown to be efficacious. However, following its withdrawal from widespread use cisapride is now only available on a named-patient basis. Other prokinetics (eg domperidone and metoclopramide) have not been evaluated in this respect.. Baclofen has been shown to reduce TLOSR and is beginning to be used by some practitioners as adjunctive treatment.. Patients who do not respond to PPIs or who require long-term high doses of acid suppressants for symptom control should be referred for a specialist opinion. Endoscopic evaluation is often followed by 24 pH monitoring (off acid suppression for five days) to confirm excessive acid reflux, preferably with a close symptom-reflux association.. Manometric evaluation should be carried out at the same time to document LOS ...
http://www.pulsetoday.co.uk/pcts-will-check-gp-records-before-transfer/10916766.article
Cisapride oral suspensionCisapride oral suspension
Visit your doctor or health care professional for regular checks on your progress. For this medicine to work properly it is important to make lifestyle changes. Eat smaller meals, elevate the head of your bed 6 to 8 inches, avoid high-fat foods, chocolate, alcohol, smoking, caffeine and carbonated drinks.. If you have any fainting spells or rapid or irregular heartbeat, stop taking this drug immediately. Contact your health care professional right away for evaluation.. Do not drink grapefruit juice while you are taking this medicine. Grapefruit juice could increase your risk of having serious side effects from this medicine.. ...
http://livinghealthy.hawaiipacifichealth.org/RelatedItems/121,1240
Pager Forum - General, Beginners and Infants - cisapride/propulsid in Canada?Pager Forum - General, Beginners and Infants - cisapride/propulsid in Canada?
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http://www.reflux.org/reflux/webdsc01.nsf/vwID/VASV-89B3UK?OpenDocument
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Therapy Alert - A Review Dr.T.R.RAMANUJAM. M.D., | MedindiaTherapy Alert - A Review Dr.T.R.RAMANUJAM. M.D., | Medindia
Cisapride is one of the frequently used prokinetic agent used in a variety of GIT disorders by virtue of its effects of its 5 HT receptor agonism.
http://www.medindia.net/articles/epharma4.asp
Prokinetic Agents - A Scientific Review of Drugs & Natural Sources in SIBOProkinetic Agents - A Scientific Review of Drugs & Natural Sources in SIBO
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https://sibosurvivor.com/prokinetic-agents/
Prokinetic Agents - A Scientific Review of Drugs & Natural Sources in SIBOProkinetic Agents - A Scientific Review of Drugs & Natural Sources in SIBO
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https://sibosurvivor.com/prokinetic-agents/?unapproved=22010&moderation-hash=2f990f5ab63ec4ae81b6fa6e69e8be32
Randomised controlled trial of cisapride in feed intolerance in preterm infants | ADC Fetal & Neonatal EditionRandomised controlled trial of cisapride in feed intolerance in preterm infants | ADC Fetal & Neonatal Edition
Many low birthweight premature babies will have feeding difficulties due to various factors related to their gut immaturity. Some of these factors include lower oesophageal sphincter pressure, delayed gastric emptying, and prolonged gastrointestinal transit time.1 Consequently, when these babies are fed by nasogastric tube, they often develop feed intolerance that is usually manifest by gastric aspirates, regurgitation, bile stained aspirates and/or abdominal distension. They may take several days to weeks to tolerate enteral feeds and are subjected to lengthy periods of parenteral nutrition.. Cisapride is a gastrointestinal prokinetic agent that acts by releasing acetylcholine from the nerve terminals of the gut. In children it increases lower oesophageal sphincter pressure,6 enhances gastric emptying,7-9 and increases intestinal transit time.10 11 It has been widely used in children for a variety of conditions including gastro-oesophageal reflux,6 12 13 intestinal pseudo-obstruction,14 15 and ...
http://fn.bmj.com/content/79/2/F110
PatientsLikeMe | Cisapride report for patients like youPatientsLikeMe | Cisapride report for patients like you
Cisapride: Find the most comprehensive real-world treatment information on Cisapride at PatientsLikeMe. 1 patients with fibromyalgia, multiple sclerosis, major depressive disorder, generalized anxiety disorder, diabetes type 2, post-traumatic stress disorder, systemic lupus erythematosus, bipolar disorder, Parkinsons disease, panic disorder, rheumatoid arthritis, high blood pressure (hypertension), myalgic encephalomyelitis/chronic fatigue syndrome, persistent depressive disorder (dysthymia), amyotrophic lateral sclerosis, epilepsy, migraine, hypothyroidism, osteoarthritis, traumatic brain injury, bipolar II disorder, attention deficit/hyperactivity disorder, asthma, social anxiety disorder, high cholesterol (hypercholesterolemia), irritable bowel syndrome, idiopathic pulmonary fibrosis, gastroesophageal reflux disease, bipolar I disorder or psoriasis currently take Cisapride.
https://www.patientslikeme.com/treatments/show/27122-cisapride-side-effects-and-efficacy
An Efficacy and Safety Study of Cisapride in Patients With Chronic Gastroparesis After Failure of Other Treatment Options -...An Efficacy and Safety Study of Cisapride in Patients With Chronic Gastroparesis After Failure of Other Treatment Options -...
This is a double-blind (neither the physician nor the patient will know the name of assigned treatment) study to determine the effectiveness of cisapride tablets compared to placebo tablets (a tablet identical in appearance to cisapride but does not contain active drug) in patients with a primary diagnosis of idiopathic gastroparesis (a disorder of unknown cause in which the stomach empties its contents very slowly into the small intestine for digestion. Symptoms of gastroparesis may include vomiting, nausea, early feeling of fullness after only a few bites of food, weight loss due to poor absorption of nutrients or low calorie intake, abdominal bloating, poor glycemic (blood sugar) control, lack of appetite, and pain in the stomach area. Patients will take study drug (one 10-mg tablet of cisapride, or one tablet of placebo), orally, 4 times a day, for a period of 8 weeks. Study drug will be taken approximately 15 minutes before each meal, and, with a beverage, before going to bed ...
https://clinicaltrials.gov/show/NCT01281540
An Efficacy and Safety Study of Cisapride in Patients With Chronic Gastroparesis After Failure of Other Treatment Options -...An Efficacy and Safety Study of Cisapride in Patients With Chronic Gastroparesis After Failure of Other Treatment Options -...
This is a double-blind (neither the physician nor the patient will know the name of assigned treatment) study to determine the effectiveness of cisapride tablets compared to placebo tablets (a tablet identical in appearance to cisapride but does not contain active drug) in patients with a primary diagnosis of idiopathic gastroparesis (a disorder of unknown cause in which the stomach empties its contents very slowly into the small intestine for digestion. Symptoms of gastroparesis may include vomiting, nausea, early feeling of fullness after only a few bites of food, weight loss due to poor absorption of nutrients or low calorie intake, abdominal bloating, poor glycemic (blood sugar) control, lack of appetite, and pain in the stomach area. Patients will take study drug (one 10-mg tablet of cisapride, or one tablet of placebo), orally, 4 times a day, for a period of 8 weeks. Study drug will be taken approximately 15 minutes before each meal, and, with a beverage, before going to bed ...
https://clinicaltrials.gov/ct2/show/record/NCT01281540
PRIME PubMed | Treating the symptoms of gastro-oesophageal reflux disease: a double-blind comparison of omeprazole and cisapridePRIME PubMed | Treating the symptoms of gastro-oesophageal reflux disease: a double-blind comparison of omeprazole and cisapride
PubMed journal article: Treating the symptoms of gastro-oesophageal reflux disease: a double-blind comparison of omeprazole and cisapride. Download Prime PubMed App to iPhone, iPad, or Android
https://www.unboundmedicine.com/medline/citation/9305487/Treating_the_symptoms_of_gastro_oesophageal_reflux_disease:_a_double_blind_comparison_of_omeprazole_and_cisapride_
Evaluation of the clinical efficacy of prokinetic drugs in the management of post-operative ileus: can retrospective data help...Evaluation of the clinical efficacy of prokinetic drugs in the management of post-operative ileus: can retrospective data help...
The objectives of the study were to determine whether retrospective data can be used to answer questions about the efficacy of prokinetic agents when used to treat horses with post-operative ileus (POI). We describe prevalence and mortality of POI with reference to treatment with four prokinetic agents. By combining data from two Hospitals a study population of 55 horses with POI following pedunculated lipoma obstruction (PLO) was established. Univariable and multivariable associations were determined between short term survival and potential explanatory variables. With death as outcome in multivariable models, breed and hospital were significantly associated with outcome but the use of prokinetic agents was not (P=0.15). However, sample size estimates indicate the low power of this study to detect differences in outcome. It was not possible definitively to evaluate the efficacy of prokinetics as treatment for POI following PLO using retrospective data. The data were suggestive of limited ...
http://epubs.surrey.ac.uk/826663/
Abscess on back/lumbar area, Dana 4 year old Abyssinian - Guinea Lynx ForumsAbscess on back/lumbar area, Dana 4 year old Abyssinian - Guinea Lynx Forums
We were initially giving Bactrim and Periactin 2x/day, Metacam in the AM, and a probiotic with pellets midday. We noticed Danas GI system may have been a little iffy the first day or so post-op and the vet suggested we start Cisapride 2x/day which definitely helped. However, we noticed about 8 days post-op that shed lost about 2oz (50g) over the course of 2 days when we ran out of her initial Periactin. Vet suggested giving Periactin again (we had extra from Nutmeg) and adjusting Cisapride to once daily. At this point we are only a couple of days into the new routine (Bactrim/Periactin 2x, Metacam/probiotic/Cisapride 1x/day), but there have still been some fluctuations. In the 2 days shes been back on Periactin she went from 1159g to 1200g (her average is about 1175-1200). Today she was 1200 at 7:30am and somehow 1150 at 10:00pm (both weights taken before meds and veggies ...
http://www.guinealynx.info/forums/viewtopic.php?f=2&t=75088&p=2279403
Prokinetic - definition of Prokinetic by The Free DictionaryProkinetic - definition of Prokinetic by The Free Dictionary
Define Prokinetic. Prokinetic synonyms, Prokinetic pronunciation, Prokinetic translation, English dictionary definition of Prokinetic. n. 1. The process of driving or propelling. 2. A driving or propelling force. pro·pul′sive , pro·pul′so·ry adj. Adj. 1. propulsive - having the power to...
https://www.thefreedictionary.com/Prokinetic
Serotonergic modulating drugs for functional gastrointestinal diseases - Spiller - 2002 - British Journal of Clinical...Serotonergic modulating drugs for functional gastrointestinal diseases - Spiller - 2002 - British Journal of Clinical...
This is a common condition in which patients suffer symptoms of upper gastric discomfort or pain in spite of normal endoscopy, ultrasound and other assessments. About one third of patients demonstrate delayed gastric emptying [49], another third demonstrate impaired gastric relaxation and about the same number demonstrate hypersensitivity to gastric distension [50, 51]. In general symptoms relate rather poorly to the abnormalities demonstrated, though Stanghellini et al.[49] found that severe vomiting and postprandial fullness together with female sex were predictive of delayed gastric emptying.. The demonstration of these abnormalities has encouraged the use of drugs to reverse them. In particular, initial interest focused on the role of cisapride, which had been shown to accelerate gastric emptying [52]. Cisapride also enhances postprandial gastric relaxation [53], whilst during fasting it increases fundal tone and perception of distension. These multiple actions may explain the somewhat ...
http://onlinelibrary.wiley.com/doi/10.1046/j.1365-2125.2002.01612.x/full
Which medications in the drug class Prokinetic Agents are used in the treatment of Constipation?Which medications in the drug class Prokinetic Agents are used in the treatment of Constipation?
Prokinetic AgentsProkinetics are promotility agents proposed for use in patients with severe constipation-predominant symptoms. Prucalopride (Motegrity)Prucalopride, a selective 5-hydroxytryptamine (s... more
https://www.medscape.com/answers/184704-25107/which-medications-in-the-drug-class-prokinetic-agents-are-used-in-the-treatment-of-constipation
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Skinny Pig Data and T-4 count - Page 5 - Guinea Lynx ForumsSkinny Pig Data and T-4 count - Page 5 - Guinea Lynx Forums
OT: this is a pretty good book and valuable reference overall, but they do discount the use of prokinetics (motility agents) in a number of diseases and disorders, including bloat/stasis. I have a very serious problem with that, since metoclopramide has been of great benefit to several of our pigs, and cisapride has been helpful to many on this board ...
http://www.guinealynx.info/forums/viewtopic.php?t=28492&start=80
Stomach Inflammation (Atrophic) in Dogs | petMDStomach Inflammation (Atrophic) in Dogs | petMD
Treatment for atrophic gastritis, once properly diagnosed, does not require hospitalization. Treatment is home based. Medications can be prescribed in order to inhibit the secretion of gastric acid, and additional antibiotics will be necessary if infection with the Helicobacter spp bacteria is suspected. If vomiting persists, prokinetic agents (designed to enhance muscle activity in the gastrointestinal tract) may be prescribed as well.. ...
https://www.petmd.com/dog/conditions/digestive/c_dg_gastric_atrophic?page=2
Investigating dynamic protocol-dependence of hERG potassium channel inhibition at 37 degrees C: Cisapride versus dofetilide :...Investigating dynamic protocol-dependence of hERG potassium channel inhibition at 37 degrees C: Cisapride versus dofetilide :...
INTRODUCTION. Pharmacological inhibition of cardiac potassium channels encoded by hERG (human ether-à-go-go-related gene) is associated with QT interval prolongation and torsades de pointes arrhythmia. Electrophysiological assays of hERG channel inhibition are integral to the safety testing of novel drug candidates. This study was conducted to compare, for the high affinity hERG inhibitors dofetilide and cisapride, hERG blockade between action potential (AP) and conventional (step and step-ramp) screening waveforms. Furthermore, it evaluated dynamic (pulse-by-pulse) protocol-dependence of hERG channel inhibition by these drugs.. METHODS. Whole-cell patch-clamp recordings were made at 37 degrees C from hERG-expressing HEK 293 cells. Half-maximal inhibitory concentrations (IC(50) values) for I(hERG) blockade were obtained using conventional voltage clamp and action potential clamp, using previously digitised ventricular and Purkinje fibre (PF) AP waveforms.. RESULTS. A more marked variation in ...
http://sro.sussex.ac.uk/42063/
Iberogast - WikipediaIberogast - Wikipedia
A 2004 meta-analysis comprising three randomized placebo-controlled studies with a total of 173 patients suggested that iberogast was more effective than placebo in relieving the most bothersome gastrointestinal symptom of functional dyspepsia as identified by each patient. Additionally, a single reference-controlled study was discussed, comparing iberogast to the prokinetic cisapride in the treatment of functional dyspepsia of the dysmotility type and finding no significant differences in efficacy or tolerability. This paper noted that, while iberogast seems to consistently provide symptomatic relief to patients, its efficacy is more evident with associated symptoms of gastro-oesophageal reflux or predominance of epigastric pain. It suggests a synergy of therapeutic mechanisms provided by the complex interactions between the GI tract and each individual component of iberogast. It also supports a promising safety profile for the formulation, but notes that its results must be confirmed ...
https://en.wikipedia.org/wiki/Iberogast
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A common polymorphism associated with antibiotic-induced cardiac arrhythmia. [PMID 14760488] Genetic variations of KCNQ1, KCNH2, SCN5A, KCNE1, and KCNE2 in drug-induced long QT syndrome patients. [PMID 16922724] Spectrum of pathogenic mutations and associated polymorphisms in a cohort of 44 unrelated patients with long QT syndrome. [PMID 19716085 ...
https://www.snpedia.com/index.php/Rs74315448
Sam vs. Lupus: GastroparesisSam vs. Lupus: Gastroparesis
Sam, I am a newcomer to your blog. I have had gastroparesis, celiac, Crohns, and small intestinal pseudo obstruction for 5 years. Long before I was diagnosed with lupus/RA/who the hell knows. I know how much it sucks. I bought my domperidone from New Zealand (sp). I didnt find it to be helpful, but I really hope it is for you! Whatever you do, stay away from reglan! It has a host of really nasty side effects. You can try and get compassionate release for cisapride. Temple university in Philly is one of the leading places for gastric pacemakers. If you have any other questions or need someone to talk to that knows what youre going through post on her and I will send you my email privately ...
http://www.samvslupus.com/2013/02/gastroparesis_14.html?showComment=1398445151518
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Faculty Results | UC Davis School of Veterinary MedicineFaculty Results | UC Davis School of Veterinary Medicine
Principal Investigator, Effects of Cisapride on gastroesophageal reflux in mechanically ventilated dogs, (Principal Investigator), UC Davis: Center for Companion Animal Health. Co-Principal Investigator, Gastrointestinal transit after laparoscopic-assisted gastropexy, Culp W (VSR) (Principal Investigator), UC Davis: Center for Companion Animal Health. Co-Principal Investigator, Effect of surgical treatment of brachycephalic obstructor syndrome on the lower esophageal area of brachycephalic dogs with evidence of hiatal herniation and gastroesophageal reflux, Mayhew P (VSR) (Principal Investigator), American College of Veterinary Surgeons. Co-Principal Investigator, Effect of surgical treatment of brachycephalic obstructor syndrome on the lower esophageal area of brachycephalic dogs with evidence of hiatal herniation and gastroesophageal reflux, (Principal Investigator), UC Davis: Center for Companion Animal Health. Principal Investigator, Prevalence of zoonotic enteric pathogens in dogs attending ...
http://www.vetmed.ucdavis.edu/faculty/results.cfm?fid=14801
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Patients with chronic constipation benefit from treatment with 5-hydroxytryptamine 4 (5-HT4) receptor agonists. However, the first-generation 5-HT4 receptor agonists cisapride and tegaserod were withdrawn from the market owing to rare cardiovascular adverse events, which were not 5-HT4-receptor-related, but due to the lack of selectivity of these drugs. Here we report the nonclinical cardiovascular profile of the selective 5-HT4 receptor agonist prucalopride. To assess its non-5-HT4 receptor-mediated effects on cardiovascular electrophysiological parameters, in vitro studies were performed in human ether-a-go-go-related gene-transfected cells, guinea pig ventricular myocytes and papillary muscle preparations, rabbit and dog Purkinje fibers, and the Langendorff rabbit heart. In vivo experiments were performed in a rabbit model for drug-induced proarrhythmogenesis, in anesthetized guinea pigs, and anesthetized and conscious dogs. In addition, human platelet aggregation and coronary artery ...
http://jpet.aspetjournals.org/content/early/2017/11/27/jpet.117.244079
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HERG K(+) channel, the genetic counterpart of rapid delayed rectifier K(+) current in cardiac cells, is responsible for many cases of inherited and drug-induced long QT syndromes. HERG has unusual biophysical properties distinct from those of other K(+) channels. While the conventional pulse protocols in patch-clamp studies have helped us elucidate these properties, their limitations in assessing HERG function have also been progressively noticed. We employed AP-clamp techniques using physiological action potential waveforms recorded from various regions of canine heart to study HERG function in HEK293 cells and identified several novel aspects of HERG function. We showed that under AP-clamp IHERG increased gradually with membrane repolarization, peaked at potentials around 20-30 mV more negative than revealed by pulse protocols and at action potential duration (APD) to 60%-70% full repolarization, and fell rapidly at the terminal phase of repolarization. We found that the rising phase of IHERG ...
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|p style=text-align: justify;|Levaquin is used for:|br /|Treating infections caused by certain bacteria. It may also be used to prevent or slow anthrax after exposure. Levaquin is a quinolone antibiotic. It works by killing sensitive bacteria.|br /|Do NOT use Levaquin if:|br /|• you are allergic to any ingredient in Levaquin or to any other quinolone antibiotic (eg, ciprofloxacin)|br /|• you have a certain type of irregular heartbeat (QT prolongation, long QT syndrome) or low blood potassium levels|br /|• you are taking cisapride or certain antiarrhythmics (eg, amiodarone, procainamide, quinidine, sotalol)|br /|Contact your doctor or health care provider right away if any of these apply to you.|br /|Before using Levaquin:|br /|Some medical conditions may interact with Levaquin . Tell your health care provider if you have any medical conditions, especially if any of the following apply to you:|br /|• if you are pregnant, planning to become pregnant, or are breast-feeding|br /|•
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Interazioni Non assumere il farmaco contemporaneamente con: cisapride; nitrato di metscopolamina; nitrati quali, nitrito, isosorbide dinitrato, isosorbide mononitrato, nitroglicerina; nitroprusside; altri farmaci a base di sildenafil (Revatio); Eyeball to eyeball trigrammic stockade had authenticly fucked off. Bound for exceptionable placer is the kindly ungifted clemmie. Helpmates were a podunks. All the time swart liberations will be insufflating. Speciali avvertenze e precauzioni per luso Prima di iniziare la somministrazione del farmaco avvisare il medico curante se una delle seguenti condizioni è occorsa: disturbi della vista, compresa la retinite pigmentosa, una rara malattia genetica dell occhio; malattie cardiache, angina, ipertensione, ipotensione, attacco di cuore o altri problemi cardiaci; malattie epatiche; malattie renali; infarto; ipersensibilità o allergie al sildenafil, altre medicine, cibo, coloranti o conservanti; Altre note interazioni medicamentose: farmaci per l ...
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Wedgewood Pharmacy Caring for AnimalsWedgewood Pharmacy Caring for Animals
Wedgewood Pharmacy, a compounding pharmacy and veterinary pharmacy. Compounding Hydroxyprogesterone, Tri-Mix, Avastin, Trilostane, Cyclosporine, Pergolide, Cisapride, Corticotrophin, ACTH, DES.
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Magaldrate Simethicone Suspension Manufacturer,Magaldrate Simethicone Suspension Supplier,HaryanaMagaldrate Simethicone Suspension Manufacturer,Magaldrate Simethicone Suspension Supplier,Haryana
Offers Magaldrate Simethicone Suspension available at an best Price in Panchkula, Haryana. We are the leading Manufacturer & Supplier of Magaldrate Simethicone Suspension.
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Cure Strategy (formerly, Serious Medicine Strategy): September 2009Cure Strategy (formerly, Serious Medicine Strategy): September 2009
Unfortunately, the FDA has never seen the choice in this fashion. FDA never keen on analyzing comparative risk or benefit of various treatments, saw risks in the use of digestive prokinetics that others simply did not see. In the case of Zelnorm, the last digestive prokinetic on the US market (which has the capability of regenerating digestive nerve and muscle tissue), FDA removed from the USA market due to a vague assessment of a 0.1% risk of cardiovascular side effects (i.e.- heart attack or angina), this was despite additional reports that the individuals who had these side effects had pre-existing cardiovascular conditions. With regard to a second prokinetic, Propulsid, Food and Drug removed it from the US market because 70 people suffered a cardiac condition known as prolonged QT syndrome, a condition that could have been diagnosed through the use of EKG. A final prokinetic, Domperidone which helps to restore proper swallowing function in individuals with paralysis never saw the light of ...
http://seriousmedicinestrategy.blogspot.com/2009_09_01_archive.html
Rhythm Presents Positive Phase 2 Study Results for Ghrelin Prokinetic Relamorelin (RM-131) inRhythm Presents Positive Phase 2 Study Results for Ghrelin Prokinetic Relamorelin (RM-131) in
BOSTON, May 6, 2014 /PRNewswire/ -- Rhythm Presents Positive Phase 2 Study Results for Ghrelin Prokinetic Relamorelin (RM-131) in Diabetic Gastroparesis.
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Medical Pharmacology Chapter 27: Gastrointestinal Pharmacology Practice QuestionsMedical Pharmacology Chapter 27: Gastrointestinal Pharmacology Practice Questions
An example of an effective prokinetic agent would be represented by muscarinic receptor agonist or by inhibitors of the enzyme acetylcholinesterase ...
https://www.pharmacology2000.com/Gastrointestinal/questionset2711/questionset2711.htm
Magaldrate 400mg+Simethicone 20mg 5 ml - 170 ml Manufacturer, Supplier, ExporterMagaldrate 400mg+Simethicone 20mg 5 ml - 170 ml Manufacturer, Supplier, Exporter
We, Accretion Pharmaceuticals is one of the prominent leading Manufacturer, Supplier and Exporter of Magaldrate 400mg+Simethicone 20mg 5 ml - 170 ml, We own a Revised Schedule M license and a plant facility is being constructed by us for the ease of manufacturing and it is under the consent of WHO guidelines from Sanand, Gujarat, India
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Pepto-Bismol Original Strength and simethicone Drug Interactions - Drugs.comPepto-Bismol Original Strength and simethicone Drug Interactions - Drugs.com
View drug interactions between Pepto-Bismol Original Strength and simethicone. These medicines may also interact with certain foods or diseases.
https://www.drugs.com/drug-interactions/pepto-bismol-original-strength-with-simethicone-391-17818-2065-0.html
Gas-X (simethicone) dose, indications, adverse effects, interactions... from PDR.netGas-X (simethicone) dose, indications, adverse effects, interactions... from PDR.net
PDR Drug Summaries are concise point-of-care prescribing, dosing and administering information to help phsyicans more efficiently and accurately prescribe in their practice PDR's drug summaries are available free of charge and serve as a great resource for US based MDs, DOs, NPs and PAs in patient practice
https://www.pdr.net/drug-summary/Gas-X-simethicone-2675
IndigestionIndigestion
Information regarding withdrawal of Propulsid (cisapride) by Janssen Pharmaceutica. From FDA Thompson Coon J, Ernst E (October ... but the studies evaluated to come to this conclusion used the drug cisapride which has since been removed from the market (now ... as one trial suggests potential benefit over placebo and another shows equivalence with cisapride. So, with the somewhat recent ...
https://en.wikipedia.org/wiki/Indigestion
Prokinetic agentProkinetic agent
As such, the relatively poor selectivity profile of cisapride versus other receptors (especially hERG [human ether-a-go-go K+] ... Some of these prokinetic agents, such as mosapride and cisapride, classic benzamides, have only moderate affinity for 5HT4 ... Benzamide Cisapride Domperidone Itopride Mosapride Metoclopramide Prucalopride Renzapride Tegaserod Mitemcinal Levosulpiride ...
https://en.wikipedia.org/wiki/Prokinetic_agent
SimeticoneSimeticone
"A randomized placebo-controlled trial of simethicone and cisapride for the treatment of patients with functional dyspepsia". ...
https://en.wikipedia.org/wiki/Simeticone
Intestinal pseudo-obstructionIntestinal pseudo-obstruction
Prucalopride, pyridostigmine, metoclopramide, cisapride, and erythromycin may be used, but they have not been shown to have ...
https://en.wikipedia.org/wiki/Intestinal_pseudo-obstruction
Drug-induced QT prolongationDrug-induced QT prolongation
Fluoroquinolones Ciprofloxacin Levofloxacin Moxifloxacin Chloroquine Cisapride Foscarnet Hydroxychloroquine Ketoconazole ...
https://en.wikipedia.org/wiki/Drug-induced_QT_prolongation
KetoconazoleKetoconazole
... cisapride, nisoldipine, dofetilide, pimozide And is not recommended: carbamazepine, phenytoin gastric acid suppressants: ...
https://en.wikipedia.org/wiki/Ketoconazole
Torsades de pointesTorsades de pointes
... the gastrokinetic drug cisapride (Propulsid) was withdrawn from the US market in 2000 after it was linked to deaths caused by ...
https://en.wikipedia.org/wiki/Torsades_de_pointes
Metadona, entziklopedia askea.Metadona, entziklopedia askea.
cisapride (en) , (RS)-citalopram (en) , clarithromycin (en) , kokaina, disopyramide (en) , dofetilide (en) , domperidone (en) ...
https://eu.wikipedia.org/wiki/Metadona
DiazepamDiazepam
Cisapride may enhance the absorption, and therefore the sedative activity, of diazepam.[78] ... Bateman DN (1986). "The action of cisapride on gastric emptying and the pharmacodynamics and pharmacokinetics of oral diazepam ...
https://en.m.wikipedia.org/wiki/Valium
5-HT4 receptor - Википедија, слободна енциклопедија5-HT4 receptor - Википедија, слободна енциклопедија
2003). „Overexpression of serotonin4 receptors in cisapride-responsive adrenocorticotropin-independent bilateral macronodular ...
https://sr.wikipedia.org/wiki/5-HT4_receptor
5-HT4 receptor5-HT4 receptor
2003). "Overexpression of serotonin4 receptors in cisapride-responsive adrenocorticotropin-independent bilateral macronodular ...
https://sh.wikipedia.org/wiki/5-HT4_receptor
IberogastIberogast
Additionally, a single reference-controlled study was discussed, comparing iberogast to the prokinetic cisapride in the ...
https://en.wikipedia.org/wiki/Iberogast
5-HT4受體 - 维基百科，自由的百科全书5-HT4受體 - 维基百科，自由的百科全书
Overexpression of serotonin4 receptors in cisapride-responsive adrenocorticotropin-independent bilateral macronodular adrenal ...
https://zh.wikipedia.org/wiki/5-HT4受體
YohimbineYohimbine
In the US, "yohimbe" preparations are sold as a dietary supplements for enhancing libido, for weight loss and as aids for bodybuilding; but "There is virtually no published research on yohimbe which supports these or any other claims".[9]:861 Often, these products explicitly claim to contain yohimbine.[8] Cohen et al. found that samples of brands sold in American brick-and-mortar stores contained highly variable amounts of yohimbine, and sometimes none at all.[8]:368 Labelling claims were often misleading.[8]:368 Similar results have been reported by other laboratories for products sold in the U.S., in other countries and on the internet.[15][16][17][18][19] One study found that many brands of "yohimbe" might not derive from the P. johimbe tree in the first place.[20] According to yet another source the yohimbe sold in markets in West Africa, where the tree grows, is frequently adulterated with other species of the genus Pausinystalia; these contain little yohimbine.[21] The amounts of alkaloid ...
https://en.wikipedia.org/wiki/Yohimbine
MethanthelineMethantheline
The topic of this article may not meet Wikipedia's general notability guideline. Please help to establish notability by citing reliable secondary sources that are independent of the topic and provide significant coverage of it beyond a mere trivial mention. If notability cannot be established, the article is likely to be merged, redirected, or deleted ...
https://en.wikipedia.org/wiki/Methantheline
LamotrigineLamotrigine
... is a member of the sodium channel blocking class of antiepileptic drugs.[60] This may suppress the release of glutamate and aspartate, two of the dominant excitatory neurotransmitters in the CNS.[61] It is generally accepted to be a member of the sodium channel blocking class of antiepileptic drugs,[62] but it could have additional actions since it has a broader spectrum of action than other sodium channel antiepileptic drugs such as phenytoin and is effective in the treatment of the depressed phase of bipolar disorder, whereas other sodium channel blocking antiepileptic drugs are not, possibly on account of its sigma receptor activity. In addition, lamotrigine shares few side-effects with other, unrelated anticonvulsants known to inhibit sodium channels, which further emphasises its unique properties.[63] It is a triazine derivate that inhibits voltage-sensitive sodium channels, leading to stabilization of neuronal membranes. It also blocks L-, N-, and P-type calcium channels and ...
https://en.wikipedia.org/wiki/Lamotrigine
CaptodiameCaptodiame
... (INN), also known as captodiamine, is an antihistamine sold under the trade names Covatine, Covatix, and Suvren which is used as a sedative and anxiolytic. The structure is related to diphenhydramine.[1] A 2004 study suggested captodiame may be helpful in preventing benzodiazepine withdrawal syndrome in people discontinuing benzodiazepine treatment.[1] In addition to its actions as an antihistamine, captodiamine has been found to act as a 5-HT2C receptor antagonist and σ1 receptor and D3 receptor agonist.[2] It produces antidepressant-like effects in rats.[2] However, captodiamine is unique among antidepressant-like drugs in that it increases brain-derived neurotrophic factor (BDNF) levels in the hypothalamus but not in the frontal cortex or hippocampus.[2] This unique action may be related to its ability to attenuate stress-induced anhedonia and corticotropin-releasing factor (CRF) signaling in the hypothalamus.[2] ...
https://en.wikipedia.org/wiki/Captodiame
DomperidoneDomperidone
The hormone prolactin stimulates lactation (production of breast milk). Dopamine, released by the hypothalamus stops the release of prolactin from the pituitary gland. Domperidone, by acting as an anti-dopaminergic agent, results in increased prolactin secretion, and thus promotes lactation (that is, it is a galactogogue). In some nations, including Australia, domperidone is used off-label, based on uncertain and anecdotal evidence of its usefulness, as a therapy for mothers who are having difficulty breastfeeding.[24][25] In the United States, domperidone is not approved for this or any other use.[26][27] A study called the EMPOWER trial was designed to assess the effectiveness and safety of domperidone in assisting mothers of preterm babies to supply breast milk for their infants.[28] The study randomized 90 mothers of preterm babies to receive either domperidone 10 mg orally three times daily for 28 days (Group A) or placebo 10 mg orally three times daily for 14 days followed by domperidone ...
https://en.wikipedia.org/wiki/Domperidone
DihydropyridineDihydropyridine
... (DHP) is a molecule based upon pyridine, and the parent of a class of molecules that have been semi-saturated with two substituents replacing one double bond. They are particularly well known in pharmacology as L-type calcium channel blockers, used in the treatment of hypertension. Compared with certain other L-type calcium channel blockers (for example those of the phenylalkylamine class such as verapamil) that have significant action at the heart, they are relatively vascular selective in their mechanism of action in lowering blood pressure. ...
https://en.wikipedia.org/wiki/Dihydropyridine
1,1,1-Trichloroethane1,1,1-Trichloroethane
... is generally considered a non-polar solvent. Owing to the good polarizability of the chlorine atoms, it is a superior solvent for organic compounds that do not dissolve well in hydrocarbons such as hexane. It is an excellent solvent for many organic materials and also one of the least toxic of the chlorinated hydrocarbons. Prior to the Montreal Protocol, it was widely used for cleaning metal parts and circuit boards, as a photoresist solvent in the electronics industry, as an aerosol propellant, as a cutting fluid additive, and as a solvent for inks, paints, adhesives, and other coatings. 1,1,1-Trichloroethane is also used as an insecticidal fumigant. It was also the standard cleaner for photographic film (movie/slide/negatives, etc.). Other commonly available solvents damage emulsion, and thus are not suitable for this application. The standard replacement, Forane 141 is much less effective, and tends to leave a residue. 1,1,1-Trichloroethane was used as a thinner in ...
https://en.wikipedia.org/wiki/1,1,1-Trichloroethane
BMY-14802BMY-14802
InChI=1S/C18H22F2N4O/c19-15-5-3-14(4-6-15)17(25)2-1-7-23-8-10-24(11-9-23)18-21-12-16(20)13-22-18/h3-6,12-13,17,25H,1-2,7-11H2 ...
https://en.wikipedia.org/wiki/BMY-14802
GR-127935GR-127935
InChI=1S/C29H31N5O3/c1-19-17-23(28-30-20(2)37-32-28)9-11-25(19)21-5-7-22(8-6-21)29(35)31-24-10-12-27(36-4)26(18-24)34-15-13-33(3)14-16-34/h5-12,17-18H,13-16H2,1-4H3,(H,31,35 ...
https://en.wikipedia.org/wiki/GR-127935
3,4-Methylenedioxy-N-ethylamphetamine3,4-Methylenedioxy-N-ethylamphetamine
Alexander Shulgin conducted research on methylenedioxy compounds in the 1960s. In a 1967 lab notebook entry, Shulgin briefly mentioned a colleague's report of no effect from the substance with a 100 mg dose.[4] Shulgin later characterized the substance in his book PiHKAL.[3] In the United States, MDEA was introduced recreationally in 1985 as a legal substitute to the newly banned MDMA.[2] MDEA was made a Schedule 1 substance in the United States on August 13, 1987 under the Federal Analog Act.[1] ...
https://en.wikipedia.org/wiki/3,4-methylenedioxy-N-ethylamphetamine
GlisoxepideGlisoxepide
InChI=1S/C20H27N5O5S/c1-15-14-18(23-30-15)19(26)21-11-10-16-6-8-17(9-7-16)31(28,29)24-20(27)22-25-12-4-2-3-5-13-25/h6-9,14H,2-5,10-13H2,1H3,(H,21,26)(H2,22,24,27) ...
https://en.wikipedia.org/wiki/Glisoxepide
25I-NBOH25I-NBOH
... acts as a potent agonist for the 5HT2A receptor,[1][2] with a Ki of 0.061 nM at the human 5HT2A receptor, similar to the better-known compound 25I-NBOMe, making it some twelve times the potency of 2C-I itself. Although in vitro tests show this compound acts as an agonist, animal studies to confirm these findings have not been reported. While the N-benzyl derivatives of 2C-I had significantly increased binding to 5HT2A receptor fragments, compared to 2C-I, the N-benzyl derivatives of DOI were less active compared to DOI.[3] 25I-NBOH is notable as one of the most selective agonist ligands for the 5-HT2A receptor with an EC50 value of 0.074 nM with more than 400 times selectivity over the 5-HT2C receptor.[4] ...
https://en.wikipedia.org/wiki/25I-NBOH
CarbamazepineCarbamazepine
... (CBZ), sold under the trade name Tegretol among others, is an anticonvulsant medication used primarily in the treatment of epilepsy and neuropathic pain.[1] It is not effective for absence or myoclonic seizures.[1] It is used in schizophrenia along with other medications and as a second-line agent in bipolar disorder.[3][1] Carbamazepine appears to work as well as phenytoin and valproate for focal and generalised seizures.[4] Common side effects include nausea and drowsiness.[1] Serious side effects may include skin rashes, decreased bone marrow function, suicidal thoughts, or confusion.[1] It should not be used in those with a history of bone marrow problems.[1] Use during pregnancy may cause harm to the baby; however, stopping the medication in pregnant women with seizures is not recommended.[1] Its use during breastfeeding is not recommended.[1] Care should be taken in those with either kidney or liver problems.[1] Carbamazepine was discovered in 1953 by Swiss chemist Walter ...
https://en.wikipedia.org/wiki/Tegretol
2,5-Dimethoxy-4-propylamphetamine2,5-Dimethoxy-4-propylamphetamine
... (DOPR) is a psychedelic drug of the phenethylamine and amphetamine chemical classes. It was first synthesized by Alexander Shulgin, and was described in his book PiHKAL (Phenethylamines i Have Known And Loved). Shulgin described DOPR is a "heavy duty psychedelic", complete with alterations of the thought process and visual distortion.[1] Very little data exists about the pharmacological properties, metabolism, and toxicity of DOPR. The alternative structural isomer DOIP, with a 4-isopropyl substitution, is also known but is around ten times weaker than DOPR, with an active dose of some 20-30 mg (as compared to 2-5 mg for DOPR).[1] ...
https://en.wikipedia.org/wiki/2,5-Dimethoxy-4-propylamphetamine
6-Nitroquipazine6-Nitroquipazine
Classen K, Göthert M, Schlicker E (June 1984). "Effects of DU 24565 (6-nitroquipazine) on serotoninergic and noradrenergic neurones of the rat brain and comparison with the effects of quipazine". Naunyn-Schmiedeberg's Archives of Pharmacology. 326 (3): 198-202. doi:10.1007/bf00505318. PMID 6206407 ...
https://en.wikipedia.org/wiki/6-Nitroquipazine
WAY-100635WAY-100635
... has also been found to increase the analgesic effects of opioid drugs in a dose-dependent manner, in contrast to 5-HT1A agonists such as 8-OH-DPAT which were found to reduce opioid analgesia.[22][23] However, since 5-HT1A agonists were also found to reduce opioid-induced respiratory depression and WAY-100635 was found to block this effect,[24] it is likely that 5-HT1A antagonists might worsen this side effect of opioids. Paradoxically, chronic administration of the very high efficacy 5-HT1A agonist befiradol results in potent analgesia following an initial period of hyperalgesia, an effect most likely linked to desensitisation and/or downregulation of 5-HT1A receptors (i.e. analogous to a 5-HT1A antagonist-like effect).[25][26][27] As with other 5-HT1A silent antagonists such as UH-301 and robalzotan, WAY 100635 can also induce a head-twitch response in rodents.[28] ...
https://en.wikipedia.org/wiki/WAY-100635
AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaTechnology, Industry, AgricultureInformation ScienceHealth Care
CisaprideDigestive System Physiological PhenomenaDigestionDigestive SystemGastrointestinal AgentsPasteurellosis, PneumonicShipsFatigue Syndrome, ChronicPleurodynia, EpidemicBipolar DisorderAttention Deficit Disorder with HyperactivityGastroesophageal RefluxAmyotrophic Lateral SclerosisParasympathomimeticsAcetylcholineUpper Gastrointestinal TractEnteric Nervous SystemBenzyl CompoundsDancingOnionsNaval MedicineDiagnosis, OralChronology as TopicSleep DeprivationAmbulatory Surgical ProceduresGastric EmptyingStomachSurgicentersGastric BalloonGastroparesisTabletsInterstitial Cells of CajalXylansCellulosePiperidinesChromatography, High Pressure LiquidIntestinal Pseudo-ObstructionEsophagogastric JunctionManometryGastrointestinal TransitColonic Pseudo-ObstructionProduct Surveillance, PostmarketingTorsades de PointesAdverse Drug Reaction Reporting SystemsLong QT SyndromeDeductibles and CoinsuranceUnited States Food and Drug AdministrationEmergency Service, HospitalEmergenciesInternetEmergency MedicineEmergency Treatment
Cisapride Compounded - 1800PetMedsCisapride Compounded - 1800PetMeds
Buy Cisapride Compounded medication online at 1800PetMeds to help speed up your pets digestive process. Get free shipping on ... Cisapride is usually given at least 30 minutes before feeding.. *Cisapride does not cure the condition for which it is given. ... Cisapride is usually given at least 30 minutes before feeding.. *Cisapride does not cure the condition for which it is given. ... What is Cisapride Compounded?. Cisapride Compounded is used in dogs and cats to speed up the digestive process without ...
https://www.1800petmeds.com/Cisapride+Compounded-prod90015.html
What is cisapride? | Technology TrendsWhat is cisapride? | Technology Trends
What is cisapride?. Cisapride. Cisapride is a gastroprokinetic agent, a drug which increases motility in the upper ... Cisapride - Pharmacology and Mechanism of Action. ... that increases gastrointestinal motility, cisapride acts as a selective ... This resulted in cisapride being voluntarily removed from the U.S ... These studies indicated that unlike cisapride, itopride ... of up to 50%, but the studies evaluated to come to this conclusion used the drug cisapride which has since been removed from ...
https://www.primidi.com/what_is_cisapride
Pager Forum - General, Beginners and Infants - cisapride/propulsid in Canada?Pager Forum - General, Beginners and Infants - cisapride/propulsid in Canada?
cisapride/propulsid in Canada?. Hi, I live in NY close to the Canadian border and wondered if Cisapride/Propulsid is available ... There are some hospitals that are doing studies and have kids who are taking Cisapride right now. One of those hospitals is ...
http://www.reflux.org/reflux/webdsc01.nsf/vwID/VASV-89B3UK?OpenDocument
Cisapride does not alter gastric volume or pH in patients undergoing ambulatory surgery.Cisapride does not alter gastric volume or pH in patients undergoing ambulatory surgery.
METHODS: Using a prospective randomised double-blind controlled design, we administered either 20 mg cisapride ... To evaluate the efficacy of 20 mg cisapride p.o. in reducing residual gastric volume and pH in adult ambulatory surgical ... Cisapride*. Double-Blind Method. Female. Gastrointestinal Contents / chemistry. Hemodynamics / drug effects. Humans. Hydrogen- ... PURPOSE: To evaluate the efficacy of 20 mg cisapride p.o. in reducing residual gastric volume and pH in adult ambulatory ...
http://www.biomedsearch.com/nih/Cisapride-does-not-alter-gastric/10608215.html
Phenomenex HPLC Application #20243: Cisapride on Lux 5µm Cellulose-2 in RPPhenomenex HPLC Application #20243: Cisapride on Lux 5µm Cellulose-2 in RP
Cisapride on Lux 5µm Cellulose-2 in RP. Column used: Lux® 5 µm Cellulose-2, LC Column 250 x 4.6 mm, Ea Part#: 00G-4457-E0 ...
https://www.phenomenex.com/Application/Detail/20243
CredibleMeds :: CisaprideCredibleMeds :: Cisapride
Cisapride should not be given if the QTc is , 450 milliseconds.. *Cisapride is contraindicated in patients with electrolyte ... The Dangers of Cisapride Drug Interactions. Updated April 12, 2000. Since 1995 several labeling changes for cisapride ( ... cisapride will still be available for specific patients, requiring health care providers and patients receiving cisapride to be ... Cisapride is metabolized primarily by the cytochrome P450 3A4 enzyme.7,56Medications that inhibit cytochrome P450 3A4, (Table I ...
https://www.crediblemeds.org/everyone/interaction-advisory/cisapride/
Cisapride tabletsCisapride tablets
Cisapride tablets. What is this medicine?. CISAPRIDE (SIS a pride) is used to treat heartburn in patients with gastroesophageal ... Cisapride has not been available in pharmacies since August 2000. For information, the manufacturer has provided the following ... an unusual or allergic reaction to cisapride, other medicines, foods, dyes, or preservatives ...
http://pbgmc.staywellsolutionsonline.com/library/encyclopedia/121,1239
Cisapride oral suspensionCisapride oral suspension
... What is this medicine?. CISAPRIDE (SIS a pride) is used to treat heartburn in patients with ... an unusual or allergic reaction to cisapride, other medicines, foods, dyes, or preservatives ...
http://pbgmc.staywellsolutionsonline.com/library/encyclopedia/121,1240
Cisapride | Project Gutenberg Self-Publishing - eBooks | Read eBooks onlineCisapride | Project Gutenberg Self-Publishing - eBooks | Read eBooks online
Cisapride , , , ,,, , , , ... World Heritage Encyclopedia, the aggregation of the largest online encyclopedias available, and ... "Propulsid (cisapride) Safety Information". Retrieved 2011-07-14.. * ^ "Drugs banned in India". Central Drugs Standard Control ... Cisapride is a gastroprokinetic agent, a drug that increases motility in the upper gastrointestinal tract. It acts directly as ... Cisapride has been used for the treatment of gastroesophageal reflux disease (GERD). There is no evidence it is effective for ...
http://self.gutenberg.org/articles/eng/Cisapride
Cisapride + methylpolysiloxane : usage, side effects, expert advice and cisapride + methylpolysiloxane based medicines | 1mgCisapride + methylpolysiloxane : usage, side effects, expert advice and cisapride + methylpolysiloxane based medicines | 1mg
... get complete information about cisapride + methylpolysiloxane including usage, side effects, drug interaction, expert advice ... Cisapride + methylpolysiloxane is used in the treatment of . ... Cisapride + methylpolysiloxane uses. Common side effects of ... along with medicines associated with cisapride + methylpolysiloxane at 1mg.com ...
https://www.1mg.com/generics/cisapride-methylpolysiloxane-401074
Mechanism of the acetylcholine-release effect of cisapride on guinea-pig gastrointestinal tract<...Mechanism of the acetylcholine-release effect of cisapride on guinea-pig gastrointestinal tract<...
Chen, H. T. ; Pan, S. / Mechanism of the acetylcholine-release effect of cisapride on guinea-pig gastrointestinal tract. In: ... Chen, H. T., & Pan, S. (1988). Mechanism of the acetylcholine-release effect of cisapride on guinea-pig gastrointestinal tract ... Chen, HT & Pan, S 1988, Mechanism of the acetylcholine-release effect of cisapride on guinea-pig gastrointestinal tract, ... Mechanism of the acetylcholine-release effect of cisapride on guinea-pig gastrointestinal tract. / Chen, H. T.; Pan, S. ...
https://tmu.pure.elsevier.com/en/publications/mechanism-of-the-acetylcholine-release-effect-of-cisapride-on-gui
Identification and characterization of human cytchrome P450 (CYP) isoforms interacting with cisapride<...Identification and characterization of human cytchrome P450 (CYP) isoforms interacting with cisapride<...
In conclusion, cisapride is metabolized by multiple CYP450s in vitro which may make prediction of cisapride drug interaction ... In conclusion, cisapride is metabolized by multiple CYP450s in vitro which may make prediction of cisapride drug interaction ... In conclusion, cisapride is metabolized by multiple CYP450s in vitro which may make prediction of cisapride drug interaction ... In conclusion, cisapride is metabolized by multiple CYP450s in vitro which may make prediction of cisapride drug interaction ...
https://indiana.pure.elsevier.com/en/publications/identification-and-characterization-of-human-cytchrome-p450-cyp-i
PCTs will check GP records before transfer | News Article | Pulse TodayPCTs will check GP records before transfer | News Article | Pulse Today
However, following its withdrawal from widespread use cisapride is now only available on a named-patient basis. Other ... Combination therapy of prokinetics, such as cisapride, with acid suppressants has been shown to be efficacious. ...
http://www.pulsetoday.co.uk/pcts-will-check-gp-records-before-transfer/10916766.article
cisapride (CHEBI:3720)cisapride (CHEBI:3720)
... is a aromatic ether (CHEBI:35618) cisapride (CHEBI:3720) is a benzamides (CHEBI:22702) cisapride (CHEBI: ... cisapride (CHEBI:3720) is a piperidines (CHEBI:26151) cisapride (CHEBI:3720) is a substituted aniline (CHEBI:48975) ... cisapride (CHEBI:3720) has role anti-ulcer drug (CHEBI:49201) cisapride (CHEBI:3720) has role gastrointestinal drug (CHEBI: ... CHEBI:3720 - cisapride. Main. ChEBI Ontology. Automatic Xrefs. Reactions. Pathways. Models. .gridLayoutCellStructure { min- ...
http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:151790
Cisapride: MedlinePlus Drug InformationCisapride: MedlinePlus Drug Information
Cisapride: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Cisapride comes as a tablet and liquid to take by mouth. Cisapride usually is taken four times a day, 15 minutes before meals ... Before taking cisapride,. *tell your doctor and pharmacist if you are allergic to cisapride or any other drugs. ... Take cisapride exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. ...
https://medlineplus.gov/druginfo/meds/a694006.html
Interactions between Olmesartan-Amlodipine-Hydrochlorothiazide Oral and potassium-wasting-diuretics-cisaprideInteractions between Olmesartan-Amlodipine-Hydrochlorothiazide Oral and potassium-wasting-diuretics-cisapride
... information about interactions between Olmesartan-Amlodipine-Hydrochlorothiazide Oral and potassium-wasting-diuretics-cisapride ... Cisapride/Potassium Wasting Diuretics Interactions. This information is generalized and not intended as specific medical advice ... 1.Prepulsid (cisapride) US prescribing information. Janssen Pharmaceutica Products, L.P. January, 2000. ... If your potassium levels are too low, cisapride may have harmful effects on your heart. ...
https://www.webmd.com/drugs/2/drug-154436/olmesartan-amlodipine-hydrochlorothiazide-oral/details/list-interaction-details/dmid-380/dmtitle-potassium-wasting-diuretics-cisapride/intrtype-drug
PatientsLikeMe | Cisapride report for patients like youPatientsLikeMe | Cisapride report for patients like you
Find the most comprehensive real-world treatment information on Cisapride at PatientsLikeMe. 1 patients with fibromyalgia, ... bipolar I disorder or psoriasis currently take Cisapride. ... Cisapride is a gastrointestinal stimulant used to treat ... What is Cisapride?. Category: Prescription Drugs false ...
https://www.patientslikeme.com/treatments/show/27122-cisapride-side-effects-and-efficacy
Cisapride and breastfeeding. Are they compatible?Cisapride and breastfeeding. Are they compatible?
Secretion of the gastrokinetic agent cisapride in human milk. Eur J Clin Pharmacol. 1986 Abstract ... How safe and acceptable is cisapride? Scand J Gastroenterol Suppl. 1989 Abstract ...
http://e-lactancia.org/breastfeeding/cisapride/product/
PRIME PubMed | Cisapride and cimetidine in the treatment of erosive esophagitisPRIME PubMed | Cisapride and cimetidine in the treatment of erosive esophagitis
Cisapride and cimetidine in the treatment of erosive esophagitis. Download Prime PubMed App to iPhone, iPad, or Android ... Cisapride for gastroesophageal reflux disease: a placebo-controlled, double-blind study.. *Double-blind comparison of cisapride ... cisapride 20 mg, cimetidine 1600 mg and cimetidine 800 mg. Improvement in reflux symptoms in the two cisapride groups was not ... cisapride 20 mg, cimetidine 1600 mg and cimetidine 800 mg. Improvement in reflux symptoms in the two cisapride groups was not ...
https://www.unboundmedicine.com/medline/citation/2210608/Cisapride_and_cimetidine_in_the_treatment_of_erosive_esophagitis_
Comparative bioavailability of two immediate release tablets of cisapride in healthy volunteersComparative bioavailability of two immediate release tablets of cisapride in healthy volunteers
Relative bioavailability of cisapride was investigated after oral administration of a test versus a reference formulation of ... immediate release tablets of cisapride, both with 10 mg per unit. The study was conducted in a two-way cross-over design, as a ... Relative bioavailability of cisapride was investigated after oral administration of a test versus a reference formulation of ... Comparative bioavailability of two immediate release tablets of cisapride in healthy volunteers Eur J Drug Metab Pharmacokinet ...
https://pubmed.ncbi.nlm.nih.gov/9842980/
Effect of cisapride on gastric and esophageal emptying in insulin-dependent diabetes mellitusEffect of cisapride on gastric and esophageal emptying in insulin-dependent diabetes mellitus
The effects of cisapride on gastric emptying, esophageal emptying, gastrointestinal symptoms, and glycemic control were ... Effect of cisapride on gastric and esophageal emptying in insulin-dependent diabetes mellitus Gastroenterology. 1987 Jun;92(6): ... Single-dose cisapride increased esophageal emptying (p less than 0.01) and both solid and liquid gastric emptying (p less than ... A third gastric and esophageal emptying test was performed after each patient had orally taken 10 mg of cisapride or placebo q. ...
https://pubmed.ncbi.nlm.nih.gov/3569766/?dopt=Abstract
PRIME PubMed | The effect of cisapride in maintaining symptomatic remission in patients with gastro-oesophageal reflux diseasPRIME PubMed | The effect of cisapride in maintaining symptomatic remission in patients with gastro-oesophageal reflux diseas
PubMed journal article The effect of cisapride in maintaining symptomatic remission in patients with gastro-oesophageal reflux ... Cisapride for gastro-oesophageal reflux and peptic oesophagitis.. *Efficacy of cisapride on symptoms and healing of gastro- ... Median time to relapse was 63 days for cisapride, 20 mg twice daily; 59 days for cisapride, 20 mg at night; and 49 days for ... RESULTS: Median time to relapse was 63 days for cisapride, 20 mg twice daily; 59 days for cisapride, 20 mg at night; and 49 ...
https://www.unboundmedicine.com/medline/citation/9399390/The_effect_of_cisapride_in_maintaining_symptomatic_remission_in_patients_with_gastro_oesophageal_reflux_disease_
Cisapride Supplier | CAS 81098-60-4 | R 51619 | Tocris BioscienceCisapride Supplier | CAS 81098-60-4 | R 51619 | Tocris Bioscience
View and buy high purity Cisapride from Tocris Bioscience. 5-HT4 agonist; stimulates intestinal ACh release. Cited in 4 ... Reviews for Cisapride. There are currently no reviews for this product. Be the first to review Cisapride and earn rewards! ... 4 Citations for Cisapride. Citations are publications that use Tocris products. Selected citations for Cisapride include: ... Keywords: Cisapride, Cisapride supplier, 5-HT4, agonists, stimulates, Serotonin, Receptors, 5-Hydroxytryptamine, stimulate, ACh ...
https://www.tocris.com/products/cisapride_1695
An Efficacy and Safety Study of Cisapride in Patients With Chronic Gastroparesis After Failure of Other Treatment Options -...An Efficacy and Safety Study of Cisapride in Patients With Chronic Gastroparesis After Failure of Other Treatment Options -...
Patients will take study drug (one 10-mg tablet of cisapride, or one tablet of placebo), orally, 4 times a day, for a period of ... Cisapride. Anti-Ulcer Agents. Gastrointestinal Agents. Serotonin Receptor Agonists. Serotonin Agents. Neurotransmitter Agents. ... An Efficacy and Safety Study of Cisapride in Patients With Chronic Gastroparesis After Failure of Other Treatment Options. This ... The purpose of this study is to assess the effectiveness of cisapride in patients with a primary diagnosis of chronic ...
https://clinicaltrials.gov/show/NCT01281540
An Efficacy and Safety Study of Cisapride in Patients With Chronic Gastroparesis After Failure of Other Treatment Options -...An Efficacy and Safety Study of Cisapride in Patients With Chronic Gastroparesis After Failure of Other Treatment Options -...
An Efficacy and Safety Study of Cisapride in Patients With Chronic Gastroparesis After Failure of Other Treatment Options. The ... Patients will take study drug (one 10-mg tablet of cisapride, or one tablet of placebo), orally, 4 times a day, for a period of ... The purpose of this study is to assess the effectiveness of cisapride in patients with a primary diagnosis of chronic ... Received prior treatment with cisapride. *Have a gycosylated hemoglobin (HbA1c) ,7% and bloodglucose of 126 mg/dL (7.0 mmol/L) ...
https://clinicaltrials.gov/ct2/show/record/NCT01281540
Phenomenex HPLC Application #20145: Cisapride on Lux 5µm Cellulose-4 in RPPhenomenex HPLC Application #20145: Cisapride on Lux 5µm Cellulose-4 in RP
Cisapride on Lux 5µm Cellulose-4 in RP. Column used: Lux® 5 µm Cellulose-4, LC Column 250 x 4.6 mm, Ea Part#: 00G-4491-E0 ...
http://www.phenomenex.com/Application/Detail/20145
Megacolon, cisapride, enemas. Now cant pee. | Ask A VetMegacolon, cisapride, enemas. Now can't pee. | Ask A Vet
My cat has Mega Colon and is being treated with CisaPride 5mg/ml suspension. I give 1 and 1/3 ml twice daily or about 1/4 tsp ... He has not had any blood in the urine since then and is only started the Cisapride again this a.m. and only gave him 1 ml and I ... Hello, My cat has Mega Colon and is being treated with CisaPride 5mg/ml suspension. I give 1 and 1/3 ml twice daily or about 1/ ...
http://www.askavetquestion.com/answer_np.php?id=94-cant-pee-constipation-issues-too
Randomised controlled trial of cisapride in feed intolerance in preterm infants | ADC Fetal & Neonatal EditionRandomised controlled trial of cisapride in feed intolerance in preterm infants | ADC Fetal & Neonatal Edition
Cisapride was well tolerated by all the infants in the study. Janssenet al 4 studied the long term side effects of cisapride at ... Cisapride or placebo was given at a dose of 0.2 ml/kg/dose (cisapride was supplied as 1 mg/ml suspension) four times daily, ... Several cases of prolonged QT interval syndrome due to cisapride have been reported.21-23 The dose of cisapride used in our ... 1990) Cisapride for intractable constipation in children: observations from an open trial. J Pediatr Gastroenterol Nutr 11:503- ...
http://fn.bmj.com/content/79/2/F110
Cisapride Compound - Available at PetMart PharmacyCisapride Compound - Available at PetMart Pharmacy
Cisapride compound is specially formulated by our pharmacist to meet your pets needs. Contact us at 877-220-6337 for more ... SKU: PMP544 Categories: For Cats, For Dogs, Non-Sterile Compound, RX Tags: Acid Reflux, cats, Cisapride, Cisapride compound, ... Cisapride Compound Basics. Cisapride Compound treats chronic constipation, megacolon, megaesophagus, and acid reflux disease. ... Cisapride Compound Warnings. Keep out of the reach of children and pets. Do not use in pets with a known allergy or ...
https://petmartpharmacy.com/product/cisapride-compound/
Serotonergic modulating drugs for functional gastrointestinal diseases - Spiller - 2002 - British Journal of Clinical...Serotonergic modulating drugs for functional gastrointestinal diseases - Spiller - 2002 - British Journal of Clinical...
Cisapride. Cisaprides prokinetic effects probably depend on its 5HT4 agonist properties [73]. It accelerates gastric emptying ... Effect of cisapride on the gastrointestinal transit of a solid meal in normal human subjects. Gut 1987; 28: 13-16.. *CrossRef ... Cisapride. Motor neurones. Stimulates increased amplitude of oesphageal peristalsis contractions and lower oesphageal sphineter ... The influence of cisapride on gastric tone and the perception of gastric distension. Aliment Pharmacol Ther 1998; 12: 761-766. ...
http://onlinelibrary.wiley.com/doi/10.1046/j.1365-2125.2002.01612.x/full
Cisapride Pharmacodynamics | PharmaceuticalCisapride Pharmacodynamics | Pharmaceutical
... cisapride has been either aloof or has had its break bound due to letters about continued QT affection due to cisapride, which ... Cisapride is a parasympathomimetic which acts as a serotonin 5-HT4… ... Cisapride Pharmacodynamics. *Leave a comment. In abounding countries (including Canada) cisapride has been either aloof or has ... Cisapride is a parasympathomimetic which acts as a serotonin 5-HT4 agonist. Dispatch of the serotonin receptors increases ...
https://fluoridekfo.wordpress.com/2013/12/23/cisapride-pharmacodynamics/
Cisapride oral suspensionCisapride oral suspension
... What is this medicine?. CISAPRIDE (SIS a pride) is used to treat heartburn in patients with ... an unusual or allergic reaction to cisapride, other medicines, foods, dyes, or preservatives ...
http://livinghealthy.hawaiipacifichealth.org/RelatedItems/121,1240
CISAPRIDE Archives - Stenlake CompoundingCISAPRIDE Archives - Stenlake Compounding
Tag: CISAPRIDE. CISAPRIDE. Posted on January 2, 2017. December 29, 2018. by admin ... Cisapride was removed from the US market in 2000, but remained available on the Australian market until 2004. During that time ... Cisapride capsules has the potential to cause cardiac arrhythmias in humans. In 1996, the Australian Drug Reaction Advisory ... In June 1998 the FDA reported there had been 38 deaths potentially attributable to cisapride from 1993-98 in the USA. A similar ...
https://www.stenlake.com.au/tag/cisapride/
Cisap - Drugs.comCisap - Drugs.com
Cisapride. Cisapride monohydrate (a derivative of Cisapride) is reported as an ingredient of Cisap in the following countries: ...
https://www.drugs.com/international/cisap.html
Cisapride Monohydrate Exporters - Vasudha PharmaCisapride Monohydrate Exporters - Vasudha Pharma
Best Cisapride Monohydrate Exporters from India, Cisapride used in the management of gastroesophageal reflux disease, ... Cisapride. Synonyms. Cisapride Monohydrate; Cisapride hydrate; Cis-4-amino-5-chloro-N-[1-[3-(4 fluorophenoxy) propyl ]-3methoxy ... Cisapride Monohydrate Exporters. We are proud to introduce ourselves as one of the best Cisapride Monohydrate Exporters in the ... Respective Advantages of Cisapride : * Cisapride increases the rate at which stomach, esophagus, and intestines move while ...
https://www.vasudhapharma.com/cisapride-monohydrate-exporters.php
Ketek (Telithromycin): Uses, Dosage, Side Effects, Interactions, WarningKetek (Telithromycin): Uses, Dosage, Side Effects, Interactions, Warning
Cisapride (CYP3A4 Substrate). Contraindicated (Plasma exposure increased). Co-administration of cisapride with repeated doses ... Cisapride. Steady state peak plasma concentrations of cisapride (an agent with the potential to increase QT interval) were ... Cisapride/Pimozide. Concomitant administration of KETEK with cisapride or pimozide is contraindicated because coadministration ...
https://www.rxlist.com/ketek-drug.htm
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PropulsidResulting in the manufacturer'sMotilityProlongation of the QT intervalGastrointestinalConclusionP450Evaluated in patients treatedSignificantlyMetabolismRiskReadPatientsAdministrationEffect of cisaprideEffects of cisaprideTreatment with cisaprideAdministration of cisaprideIntestinalRelease of acetylcholineIncreasesGastricMetabolism of cisaprideGastrointestinal prokinetic agentDosageEsophagealJanssen PharmaceuticaMegacolonGastro-oesophageal refluxEfficacyCimetidineGastroesophageal refluxTabletsMedicationsInfantsHERGDofetilideMonohydrateGastroparesis1993AgonistBenzamidesSymptomaticMedicationEsomeprazolePrepulsidCardiacInhibit
Propulsid1
  • Since 1995 several labeling changes for cisapride (Propulsid, Janssen Pharmaceutica) have been required by the Food and Drug Administration (FDA) following serious adverse effects that were reported through the MedWatch reporting program. (crediblemeds.org)
Resulting in the manufacturer's1
  • 67 This has occurred despite repeated warnings, resulting in the manufacturer's decision to stop marketing cisapride in the United States as of July 14, 2000. (crediblemeds.org)
Motility1
Prolongation of the QT interval1
  • During post-marketing surveillance, cisapride has been associated with prolongation of the QT interval on the electrocardiogram (ECG). (crediblemeds.org)
Gastrointestinal1
  • Chen, HT & Pan, S 1988, ' Mechanism of the acetylcholine-release effect of cisapride on guinea-pig gastrointestinal tract ', Chinese Medical Journal (Taipei) , vol. 41, no. 4, pp. 263-270. (elsevier.com)
Conclusion1
  • In conclusion, cisapride is metabolized by multiple CYP450s in vitro which may make prediction of cisapride drug interaction and cardiac toxicity more difficult than described in the manufacturer's labels. (elsevier.com)
P4502
  • Cisapride is metabolized primarily by the cytochrome P450 3A4 enzyme. (crediblemeds.org)
  • 7,56 Medications that inhibit cytochrome P450 3A4, (Table I), can lead to increased plasma cisapride concentrations in patients. (crediblemeds.org)
Evaluated in patients treated1
  • Serum electrolytes should be evaluated in patients treated with diuretics prior to initiating cisapride and periodically thereafter during treatment with cisapride. (crediblemeds.org)
Significantly1
  • The formation rate of M1 and 10μM cisapride in 15 HLMs significantly correlated with the activities of CYP3A, 2C19 and 1A2. (elsevier.com)
Metabolism2
  • Using human liver microsomes (HLMs) and recombinant CYP450s, we characterized the metabolism of cisapride and documented its inhibitory effect on CYP450s. (elsevier.com)
  • Cisapride appears to inhibit CYP2D6-mediated metabolism in a stereoselective manner. (elsevier.com)
Risk1
  • Recent recommendations by Janssen Pharmaceutica and the FDA have identified patients who may be at risk for this complication associated with cisapride. (crediblemeds.org)
Read1
Patients3
  • 4,7,16,56 Subsequently, cisapride was associated with the potentially fatal arrhythmia torsades de pointes when taken with certain medications or in patients who have certain underlying conditions predisposing them to arrhythmias. (crediblemeds.org)
  • All patients should have a 12-lead ECG obtained before initiating cisapride therapy. (crediblemeds.org)
  • Cisapride is contraindicated in patients with electrolyte imbalances (hypokalemia, hypocalcemia and hypomagnesmia). (crediblemeds.org)
Administration1
  • Cisapride may be mixed with a small amount of food to ease administration. (1800petmeds.com)
Effect of cisapride1
  • Chen, HT & Pan, S 1988, ' Mechanism of the acetylcholine-release effect of cisapride on guinea-pig gastrointestinal tract ', Chinese Medical Journal (Taipei) , vol. 41, no. 4, pp. 263-270. (elsevier.com)
Effects of cisapride2
  • The effects of cisapride on gastric emptying, esophageal emptying, gastrointestinal symptoms, and glycemic control were evaluated in 20 insulin-dependent diabetics who had delayed gastric emptying of the solid or liquid component of a meal, or both. (nih.gov)
  • Bernardini S, Semama DS, Huet F et al: Effects of cisapride on QTc interval in neonates. (lhsc.on.ca)
Treatment with cisapride2
  • They showed a significant reduction in gastric residuals after 48 hours of treatment with cisapride. (bmj.com)
  • Serum electrolytes should be evaluated in patients treated with diuretics prior to initiating cisapride and periodically thereafter during treatment with cisapride. (crediblemeds.org)
Administration of cisapride3
  • After administration of cisapride for 4 wk, gastric emptying of solid and liquid were faster (p less than 0.001), but esophageal emptying was not significantly different from the placebo test. (nih.gov)
  • These results indicate that single-dose cisapride increases esophageal emptying in insulin-dependent diabetics and that chronic administration of cisapride is effective in the treatment of diabetic gastroparesis. (nih.gov)
  • 05). Conclusions and Clinical Relevance: Preanesthetic administration of cisapride and esomeprazole decreases the number of RE in anesthetized dogs, but administration of esomeprazole alone was associated with nonacid and weakly acidic reflux in all but 1 dog. (elsevier.com)
Intestinal3
  • Cisapride Compound increases intestinal muscle contractions in animals that suffer from food compaction. (petmartpharmacy.com)
  • Cisapride for intestinal constipation. (gutenberg.org)
  • Cisapride is used in small animals to stimulate intestinal contractions, and to treat chronic constipation or other conditions where food and waste materials have stopped moving through the gastrointestinal tract. (catdoc.com)
Release of acetylcholine2
  • Cisapride increases the release of acetylcholine, which in turn stimulates the smooth muscle in the digestive tract to contract more frequently. (petmartpharmacy.com)
  • Cisapride is a potent third generation prokinetic agent acting on postganglionic receptors by increasing the release of acetylcholine. (elsevier.com)
Increases4
  • Cisapride increases the accent and amplitude of belly (especially antral) contractions, relaxes the pyloric sphincter and the belly bulb, and increases peristalsis of the duodenum and jejunum consistent in accelerated belly elimination and abdominal transit. (wordpress.com)
  • Objective: To determine whether preanesthetic IV administration of esomeprazole alone or esomeprazole and cisapride increases esophageal pH and decreases the frequency of GER in anesthetized dogs using combined multichannel impedance and pH monitoring. (elsevier.com)
  • cisapride is a gastrokinetic drug that increases esophageal peristaltic activity and lower esophageal sphincter tone. (lhsc.on.ca)
  • The increases in the motilin level after cisapride or renzapride coincided with significant increases in contractile activities of the antrum to 43.2 ± 5.3% and 44.9 ± 4.6% and of the duodenum to 28.4 ± 3.1% and 34.2 ± 2.2% of phase III activity (100%) from that in the corresponding control period, 0.7 ± 0.4% and 0.2 ± 0.1%, respectively. (elsevier.com)
Gastric12
  • On 2 days each patient received cisapride (20 mg) or placebo orally, 60 min before an esophageal and gastric emptying test. (nih.gov)
  • A third gastric and esophageal emptying test was performed after each patient had orally taken 10 mg of cisapride or placebo q.i.d. for 4 wk. (nih.gov)
  • Single-dose cisapride increased esophageal emptying (p less than 0.01) and both solid and liquid gastric emptying (p less than 0.001). (nih.gov)
  • The response to cisapride was most marked in patients with the greatest delay in esophageal and gastric emptying (p less than 0.05). (nih.gov)
  • Cisapride does not alter gastric volume or pH in patients undergoing ambulatory surgery. (biomedsearch.com)
  • PURPOSE: To evaluate the efficacy of 20 mg cisapride p.o. in reducing residual gastric volume and pH in adult ambulatory surgical patients. (biomedsearch.com)
  • RESULTS: Residual gastric volumes were similar in the two groups (19.5 +/- 23.8, 23.9 +/- 24.4 ml), in the cisapride and placebo groups respectively, P=0.24). (biomedsearch.com)
  • The proportions of patients with a residual gastric volume exceeding 0.4 ml x kg(-1) were similar in the two groups (4 of 28, and 8 of 23 patients in the cisapride and placebo groups respectively, P=0.09). (biomedsearch.com)
  • The pH of the residual gastric contents were similar in the cisapride and placebo groups (1.6 +/- 0.5, 1.4 +/- 0.5, respectively, P=0.26). (biomedsearch.com)
  • CONCLUSIONS: Preoperative administration of 20 mg cisapride p.o. to patients scheduled for outpatient surgery does not alter either the volume or the pH of gastric contents. (biomedsearch.com)
  • Cisapride stimulates action of the high gastrointestinal amplitude after aesthetic gastric, biliary, or pancreatic secretions. (wordpress.com)
  • Cisapride is used to treat gastric reflux (the regurgitation of stomach acid into the esophagus), which is usually experienced as heartburn. (vasudhapharma.com)
Metabolism of cisapride2
  • The second group is patients taking medications that inhibit the metabolism of cisapride (eg. (stenlake.com.au)
  • Using human liver microsomes (HLMs) and recombinant CYP450s, we characterized the metabolism of cisapride and documented its inhibitory effect on CYP450s. (elsevier.com)
Gastrointestinal prokinetic agent1
  • Context: Adverse cardiac events, typically long QT syndrome, have been reported in patients treated with the gastrointestinal prokinetic agent cisapride. (elsevier.com)
Dosage2
  • One hundred and twenty-nine patients were assigned to one of four dosage schedules: cisapride 10 mg b.i.d. (20 mg group) or q.i.d. (40 mg group), or cimetidine 400 mg b.i.d. (800 mg group) or q.i.d. (1600 mg group). (unboundmedicine.com)
  • Bedu A, Lupoglazoff JM, Faure C et al : Cisapride high dosage and long QT interval (Letter). (lhsc.on.ca)
Esophageal3
  • In a prospective, self-controlled study the prokinetic action of cisapride was tested on pedicled stomach, jejunum and colon grafts used for substitute after esophageal resection. (elsevier.com)
  • Esophageal transit scintigraphy was performed before and after cisapride administration. (elsevier.com)
  • Cisapride exerts prokinetic effect on pedicled stomach and jejunum substitutes after esophageal resection. (elsevier.com)
Janssen Pharmaceutica1
  • Recent recommendations by Janssen Pharmaceutica and the FDA have identified patients who may be at risk for this complication associated with cisapride. (crediblemeds.org)
Megacolon2
  • Megacolon, cisapride, enemas. (askavetquestion.com)
  • Cisapride is still available in the United States and Canada for use in animals, and is commonly prescribed by veterinarians to treat megacolon in cats. (gutenberg.org)
Gastro-oesophageal reflux1
  • Cisapride treatment for gastro-oesophageal reflux in children. (gutenberg.org)
Efficacy3
  • The efficacy of cisapride, as compared with cimetidine, in the treatment of erosive esophagitis was studied in a double-blind trial. (unboundmedicine.com)
  • AIM To assess the efficacy of cisapride in reducing the time required to establish enteral feeds in preterm infants. (bmj.com)
  • 2 3 In an uncontrolled trial, Janssens et al 4 studied the efficacy of cisapride in 20 preterm infants of less than 34 weeks of gestation. (bmj.com)
Cimetidine4
  • Endoscopy did not show any significant differences among the four groups, although cisapride tended to be more effective in moderate to severe esophagitis, in which cases mucosal healing (i.e. absence of erosions and ulcers) was observed in 69%, 64%, 55% and 55% of the patients treated with cisapride 40 mg, cisapride 20 mg, cimetidine 1600 mg and cimetidine 800 mg. (unboundmedicine.com)
  • Improvement in reflux symptoms in the two cisapride groups was not significantly different from that in the cimetidine 1600 mg group, but was better (p less than 0.05) than that in the cimetidine 800 mg patients. (unboundmedicine.com)
  • The severity score for all reflux symptoms had decreased by 79%, 74% (cisapride 40 mg and 20 mg), 69% and 57% (cimetidine 1600 mg and 800 mg) by the end of treatment. (unboundmedicine.com)
  • TY - JOUR T1 - Cisapride and cimetidine in the treatment of erosive esophagitis. (unboundmedicine.com)
Gastroesophageal reflux2
Tablets2
  • Relative bioavailability of cisapride was investigated after oral administration of a test versus a reference formulation of immediate release tablets of cisapride, both with 10 mg per unit. (nih.gov)
  • The two formulations were administered in two treatment days , separated by a washout period of 6 days, in fasted subjects who received one single oral dose of 20 mg of one study medication of cisapride as two 10 mg tablets. (nih.gov)
Medications3
  • Cisapride may interact with some other medications. (petmartpharmacy.com)
  • 4,7,16,56 Subsequently, cisapride was associated with the potentially fatal arrhythmia torsades de pointes when taken with certain medications or in patients who have certain underlying conditions predisposing them to arrhythmias. (crediblemeds.org)
  • 7,56 Medications that inhibit cytochrome P450 3A4, (Table I), can lead to increased plasma cisapride concentrations in patients. (crediblemeds.org)
Infants1
  • CONCLUSION The routine use of cisapride in preterm infants cannot be recommended to decrease the time to establish enteral feeds. (bmj.com)
HERG5
  • This study was conducted to compare, for the high affinity hERG inhibitors dofetilide and cisapride, hERG blockade between action potential (AP) and conventional (step and step-ramp) screening waveforms. (sussex.ac.uk)
  • however, I(hERG) blockade by each drug was initially voltage-dependent, but at steady-state was only voltage-dependent for cisapride. (sussex.ac.uk)
  • Features of time-dependence of blockade and the use of protocols employing varying rest periods in drug or commands of alternating duration highlighted a pronounced ability of cisapride, but not dofetilide, to dissociate and reassociate from hERG on a pulse-by-pulse basis. (sussex.ac.uk)
  • Protocols described here that demonstrated dynamic variation (drug dissociation/reassociation) in hERG channel current blockade at 37 degrees C for cisapride may have future value for investigating drug interactions with the hERG channel. (sussex.ac.uk)
  • As such, the relatively poor selectivity profile of cisapride versus other receptors (especially hERG [human ether-a-go-go K+] channels) contributes to its potential to cause cardiac arrhythmias. (wikipedia.org)
Dofetilide1
  • A more marked variation in IC(50) values with different command waveforms was observed for cisapride (ranging from 7 to 72 nM) than for dofetilide (ranging from 4 to 15 nM), with higher IC(50)s obtained with AP than step or step-ramp commands. (sussex.ac.uk)
Monohydrate2
  • We are proud to introduce ourselves as one of the best Cisapride Monohydrate Exporters in the pharmaceutical industry. (vasudhapharma.com)
  • Vasudha Pharma( Cisapride Monohydrate Exporters ) the above results indicated that the cisapride is safe and effective to use. (vasudhapharma.com)
Gastroparesis1
  • The purpose of this study is to assess the effectiveness of cisapride in patients with a primary diagnosis of chronic gastroparesis (a stomach disorder) of unknown cause. (clinicaltrials.gov)
19931
  • In June 1998 the FDA reported there had been 38 deaths potentially attributable to cisapride from 1993-98 in the USA. (stenlake.com.au)
Agonist1
  • Cisapride is a parasympathomimetic which acts as a serotonin 5-HT4 agonist. (wordpress.com)
Benzamides1
  • Some of these prokinetic agents, such as mosapride and cisapride, classic benzamides, have only moderate affinity for 5HT4 receptors. (wikipedia.org)
Symptomatic1
  • Cisapride has well-documented prokinetic effects and may be well suited for long-term therapy of GORD, but its effectiveness in purely symptomatic treatment is unknown. (unboundmedicine.com)
Medication2
  • The study indicates that cisapride is of limited value in maintenance therapy of GORD in patients in whom symptom relief has been accomplished with potent antisecretory medication. (unboundmedicine.com)
  • This medication, as Cisapride capsules, is also used for felines. (stenlake.com.au)
Esomeprazole1
  • Dogs were randomized to receive IV saline (0.9% NaCl), esomeprazole (1 mg/kg) alone, or a combination of esomeprazole (1 mg/kg) and cisapride (1 mg/kg) 12-18 hours and 1-1.5 hours before anesthetic induction. (elsevier.com)
Prepulsid1
  • 1.Prepulsid (cisapride) US prescribing information. (webmd.com)
Cardiac3
  • Cisapride capsules has the potential to cause cardiac arrhythmias in humans. (stenlake.com.au)
  • In 1996, the Australian Drug Reaction Advisory Committee (ADRAC) reported nine cases of cardiac arrhythmia associated with cisapride. (stenlake.com.au)
  • In conclusion, cisapride is metabolized by multiple CYP450s in vitro which may make prediction of cisapride drug interaction and cardiac toxicity more difficult than described in the manufacturer's labels. (elsevier.com)
Inhibit1
  • Cisapride appears to inhibit CYP2D6-mediated metabolism in a stereoselective manner. (elsevier.com)