DiseasesChemicals and DrugsPhenomena and ProcessesTechnology, Industry, Agriculture
CisaprideGastrointestinal AgentsPiperidinesGastric EmptyingGastrointestinal MotilitySimethiconeDomperidoneSerotonin AntagonistsMetoclopramideEther-A-Go-Go Potassium ChannelsGastroesophageal Reflux
Cisapride
A substituted benzamide used for its prokinetic properties. It is used in the management of gastroesophageal reflux disease, functional dyspepsia, and other disorders associated with impaired gastrointestinal motility. (Martindale The Extra Pharmacopoeia, 31st ed)
Gastrointestinal Agents
Drugs used for their effects on the gastrointestinal system, as to control gastric acidity, regulate gastrointestinal motility and water flow, and improve digestion.
Piperidines
A family of hexahydropyridines.
Gastric Emptying
The evacuation of food from the stomach into the duodenum.
Gastrointestinal Motility
The motor activity of the GASTROINTESTINAL TRACT.
Simethicone
A poly(dimethylsiloxane) which is a polymer of 200-350 units of dimethylsiloxane, along with added silica gel. It is used as an antiflatulent, surfactant, and ointment base.
Domperidone
A specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.
Serotonin Antagonists
Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or SEROTONIN RECEPTOR AGONISTS.
Metoclopramide
A dopamine D2 antagonist that is used as an antiemetic.
Ether-A-Go-Go Potassium Channels
A family of voltage-gated potassium channels that are characterized by long N-terminal and C-terminal intracellular tails. They are named from the Drosophila protein whose mutation causes abnormal leg shaking under ether anesthesia. Their activation kinetics are dependent on extracellular MAGNESIUM and PROTON concentration.
Gastroesophageal Reflux
Retrograde flow of gastric juice (GASTRIC ACID) and/or duodenal contents (BILE ACIDS; PANCREATIC JUICE) into the distal ESOPHAGUS, commonly due to incompetence of the LOWER ESOPHAGEAL SPHINCTER.

Delayed gastric emptying after Billroth I pylorus-preserving pancreatoduodenectomy: effect of postoperative time and cisapride. (1/188)

OBJECTIVE: To study the recovery course of gastric emptying after Billroth I pylorus-preserving pancreatoduodenectomy (PPPD) and therapeutic effects of cisapride. METHODS: To examine gastric emptying, acetaminophen was given, admixed in a pasty liquid meal, to 16 patients undergoing PPPD before surgery and at 1, 3, 6, 9, and 12 months after surgery. Cisapride was given orally to 10 patients before they received the acetaminophen regimen. Electrogastrography was performed at 2 weeks to 1 month after surgery in eight patients and at 6 to 12 months after surgery in seven patients. RESULTS: Gastric emptying was delayed but returned to the preoperative level by 6 months after surgery. Pretreatment with cisapride accelerated gastric emptying during months 1 to 6 but not during months 6 to 12 after surgery. Electrogastrography frequently showed tachygastria 2 weeks to 1 month after surgery, but seldom 6 to 12 months after surgery. CONCLUSIONS: After Billroth I PPPD, gastric emptying is delayed but recovers by 6 months after surgery. Tachygastria may play a part in the pathogenesis of delayed gastric emptying, but it can be treated with cisapride.  (+info)

Intestinal prokinesia by two esters of 4-amino-5-chloro-2- methoxybenzoic acid: involvement of 5-hydroxytryptamine-4 receptors and dissociation from cardiac effects in vivo. (2/188)

In five fasting, conscious dogs, we compared the prokinetic action of two selective 5-hydroxytryptamine-4 (5-HT4) receptor agonists with low affinity for 5-HT3 receptors ML10302 (2-piperidinoethyl 4-amino-5-chloro-2-methoxybenzoate) and SR59768 (2-[(3S)-3-hydroxypiperidino]ethyl 4-amino-5-chloro-2-methoxybenzoate) in the duodenum and jejunum, using cisapride as a reference compound. Heart rate and rate-corrected QT (QTc) also were monitored to assess whether or not the cardiac effects of cisapride are shared by other 5-HT4 receptor agonists. Both ML10302 and SR59768 dose-dependently stimulated spike activity in the duodenum with similar potencies (dose range, 3-300 nmol/kg i.v.; ED50 values: 24 and 23 nmol/kg i.v., respectively), mimicking the effect of cisapride (30-3000 nmol/kg i.v.). The maximal effect was achieved with the dose of 100 nmol/kg i.v. for both compounds. Similar findings were obtained in the jejunum. Atropine and GR125487 (1-[2-[(methylsulfonyl)amino]ethyl]-4-piperidinyl-methyl 5-fluoro-2-methoxy-1H-indole-3-carboxylate, selective 5-HT4 receptor antagonist), at doses having no effect per se, antagonized intestinal prokinesia by maximal doses of ML10302 and SR59768. Neither ML10302 nor SR59768 had any effect on heart rate or QTc at any of the doses tested, whereas cisapride, at the highest dose (3000 nmol/kg), induced tachycardia and lengthened the QTC (p <.01). In conclusion, ML10302 and SR59768 share with cisapride a similar prokinetic action in the canine duodenum and jejunum in vivo. This effect is mediated by pathways involving activation of 5-HT4 and muscarinic receptors. Unlike cisapride, which induces tachycardia and prolongs the QTc by a mechanism probably unrelated to 5-HT4 receptor activation, ML10302 and SR59768 are devoid of cardiac effects in this model.  (+info)

A simple high-performance liquid chromatography assay for the major cisapride metabolite, norcisapride, in human urine. (3/188)

A simple high-performance liquid chromatography assay using fluorescence detection for the major metabolite of the gastric prokinetic drug cisapride, norcisapride, is presented. Analysis is performed using an Alltech Platinum EPS C8 column with a mobile phase made up of methanol and 0.02M sodium dihygrogen phosphate (45:55, v/v) containing triethylamine (1 g/L). Complete resolution is achieved among norcisapride, the internal standard (metoclopramide), and endogenous urinary components. The assay is linear over the range 50-2000 ng/mL with a mean recovery of 71.2% across the analytical range following solvent extraction with toluene-isoamyl alcohol (95:5, v/v). Intraday coefficients of variation (precision) determined at 200 and 1000 ng/mL are 6.0 and 9.8%, respectively, and interday coefficients of variation are 8.8 and 6.6%, respectively. Intra- and interassay accuracy (as mean relative error) determined at the same concentrations is within 10% in all cases. An analysis of urine samples from a healthy volunteer following the administration of a single 10-mg oral dose of cisapride is shown.  (+info)

Clinical considerations in GERD (gastroesophageal reflux disease) therapy: focus on cisapride. (4/188)

Heartburn, the major symptom of gastrointestinal reflux disease (GERD), is a common condition that is usually self-treated with over-the-counter products. For patients with severe or recurrent symptoms of GERD, pharmacologic therapy includes acid suppression with H2-receptor antagonists and proton pump inhibitors, and, alternatively, the use of prokinetic agents. While all of these are efficacious, given its high efficacy in nonerosive and mild-to-moderate erosive esophagitis, the prokinetic agent cisapride deserves significant consideration in this patient population.  (+info)

Identification of SK-951, a novel benzofuran derivative, as an agonist to 5-HT4 receptors. (5/188)

The pharmacological profile of SK-951 ((-)4-amino-N-[2-(1-azabicyclo[3.3.0]octan-5-yl) ethyl]-5-chloro-2,3-dihydro-2-methylbenzo[b]furan-7-carboxamide hemifumarate) was identified in relation to serotonin 5-HT3 and 5-HT4 receptors by the receptor binding assay and functional studies. The receptor binding assay showed that SK-951 bound to the 5-HT3 receptor with a high affinity, to the 5-HT4 receptor with relatively higher affinity and to the muscarinic M2 receptor with a low affinity, but not to dopamine D1 and D2 and serotonin 5-HT1 and 5-HT2 and muscarinic M1 and M3 receptors. SK-951 caused relaxations of tunica muscularis mucosae preparations from rat esophagus which were precontracted with carbachol, and the effects were antagonized by GR113808, a selective 5-HT4 antagonist. In the longitudinal muscle with myenteric plexus (LMMP) preparations from guinea pig ileum, SK-951 enhanced the electrically-stimulated contraction of preparations in which the 5-HT1, 5-HT2 and 5-HT3 receptors were blocked, and it enhanced the electrically-stimulated release of [3H]acetylcholine (ACh). These effects of SK-951 were antagonized by GR113808. SK-951 inhibited the 5-HT3 receptor-mediated contractions. These results indicate that SK-951 possesses properties of an agonist for the 5-HT4 receptor and an antagonist for the 5-HT3 receptor. Thus, SK-951 is a new and potent 5-HT4-receptor agonist and causes contractions of guinea pig ileum mediated by enhancement of ACh release via the 5-HT4 receptor.  (+info)

Randomised controlled trial of cisapride in preterm infants. (6/188)

AIM: To determine the effect of cisapride on gastrointestinal motility in preterm infants. METHODS: Cisapride (0.2 mg/kg, 8 hourly ) or placebo was given first for seven days in a double blind randomised crossover study of 10 preterm infants. Gastrointestinal motility was assessed on day 3 of each treatment. The half gastric emptying time (GET1/2) was determined by using ultrasonography to measure the decrease in the gastric antral cross sectional area after a feed. The whole gastrointestinal transit time (WGTT) was assessed by timing the transit of carmine red through the gut. Treatments were compared using the Wilcoxon matched pairs signed ranks test. RESULTS: Median (range) birthweight was 1200 (620, 1450) g and postconceptional age 33 (29, 34) weeks at recruitment. GET1/2 was significantly longer during cisapride treatment than during placebo; the median of the differences (95% confidence interval) was 19.2 (11, 30 minutes, p=0.008). WGTT was also longer during cisapride treatment, but the difference was not significant; the median of the differences was 11(-18, 52 hours, p=0.1). CONCLUSIONS: Cisapride delays gastric emptying and may delay WGTT in preterm infants. Its use to promote gastrointestinal motility in this group cannot be recommended.  (+info)

The effect of cisapride on duodenal acid exposure in the proximal duodenum in healthy subjects. (7/188)

AIM: To investigate the effect of the prokinetic drug, cisapride, on fasting and postprandial acid exposure in the proximal duodenum. METHODS: Using a double-blind, placebo-controlled crossover study design, 12 healthy male volunteers were studied. After 1 week of dosing (cisapride 20 mg b.d. orally or placebo), fasting and postprandial antroduodenal pH-and pressure-recordings were made. Using a small-caliber (4 mm) catheter, containing one antral and two duodenal pH electrodes, and two antral and three duodenal pressure recording sites. Transmucosal potential difference was measured to ensure proper catheter position. Infusions of 0.1 N HCl were given in the duodenal bulb. RESULTS: Endogenous acidification of the duodenal bulb occurred more frequently during phase II and postprandially, compared to phase I (P<0.001). During phase I, alkalinization of the antrum was observed. Cisapride significantly increased the postprandial number of duodenal acidic periods (P<0.02), but shortened their duration (P<0.04). The duodenal motor response elicited by exogenous acid was lower during phase I (P<0.05). CONCLUSIONS: Antral and proximal duodenal acidity vary with the phases of the interdigestive motor complex. Cisapride shortens the individual periods of duodenal acidification.  (+info)

Duodenogastric reflux: clinical and therapeutic aspects. (8/188)

BACKGROUND: Duodenogastric reflux is believed to cause damage to gastric mucosa. Most reports on this disorder concern adult patients. PATIENTS AND METHODS: 1120 children with abdominal pain were studied; endoscopic features of duodenogastric reflux were found in 92 patients. To confirm the diagnosis of duodenogastric reflux, cholescintigraphy (Tc99-HEPIDA) was performed. Children with confirmed duodenogastric reflux by scintigraphy were given a prokinetic drug (cisapride). RESULTS: Endoscopic features of duodenogastric reflux were found in 92 children; the diagnosis was confirmed by scintigraphy in 59 patients. There was no significant difference in the severity of inflammation in gastric mucosa compared with the control group, whereas significantly fewer of these patients were infected with Helicobacter pylori. There was no correlation between regions of isotope accumulation and inflammatory lesions in the stomach. The prokinetic drug (cisapride) helped eliminate or greatly reduce duodenogastric reflux in children. CONCLUSIONS: When endoscopic features of duodenogastric reflux are found the final diagnosis should be based on an examination that does not itself influence the motility of the gastrointestinal tract: cholescintigraphy seems to be a useful method. However, because the use of milk as a test meal affects the scintigraphic image, there was no correlation between the area of isotope accumulation and the localisation of inflammatory lesions in the stomach. Duodenogastric reflux seems to be less important as a cause of inflammatory lesions than other factors (such as genetic predisposition, stress, etc). Prokinetic drugs have a beneficial influence on treatment results in children with inflammatory lesions of gastric mucosa with duodenogastric reflux.  (+info)

Identification and characterization of human cytchrome P450 (CYP) isoforms interacting with cisapride<...
TY - JOUR. T1 - Identification and characterization of human cytchrome P450 (CYP) isoforms interacting with cisapride. AU - Desta, Zeruesenay. AU - Thacker, David. AU - Soukhova, Nadia. AU - Shin, Jae Gook. AU - Flockhart, David A.. PY - 1999/1/1. Y1 - 1999/1/1. N2 - Using human liver microsomes (HLMs) and recombinant CYP450s, we characterized the metabolism of cisapride and documented its inhibitory effect on CYP450s. Two cisapride enantiomers (EI and EII) were separated and fractions collected for study. HPLC chromatograms of HLM incubates of cisapride separated 3 metabolite peaks, M1-M3. The identity of M1 is consistent with norcisapride, while M2 and M3 may represent oxidative hydroxylation of the fluorophenyl ring. The formation rate of M1 and 10μM cisapride in 15 HLMs significantly correlated with the activities of CYP3A, 2C19 and 1A2. Of CYP isoform specific inhibitors tested, ketoconazole potently inhibited the formation of M1, M2 and M3. Of the 10 recombinant CYP450s tested, CYP3A4, ...
https://indiana.pure.elsevier.com/en/publications/identification-and-characterization-of-human-cytchrome-p450-cyp-i
Cisapride + methylpolysiloxane : usage, side effects, expert advice and cisapride + methylpolysiloxane based medicines | 1mgCisapride + methylpolysiloxane : usage, side effects, expert advice and cisapride + methylpolysiloxane based medicines | 1mg
Cisapride + methylpolysiloxane is used in the treatment of .get complete information about cisapride + methylpolysiloxane including usage, side effects, drug interaction, expert advice along with medicines associated with cisapride + methylpolysiloxane at 1mg.com
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Mechanism of the acetylcholine-release effect of cisapride on guinea-pig gastrointestinal tract<...
TY - JOUR. T1 - Mechanism of the acetylcholine-release effect of cisapride on guinea-pig gastrointestinal tract. AU - Chen, H. T.. AU - Pan, S.. PY - 1988/1/1. Y1 - 1988/1/1. UR - http://www.scopus.com/inward/record.url?scp=0023689373&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0023689373&partnerID=8YFLogxK. M3 - Article. C2 - 3179814. AN - SCOPUS:0023689373. VL - 41. SP - 263. EP - 270. JO - Journal of the Chinese Medical Association. JF - Journal of the Chinese Medical Association. SN - 1726-4901. IS - 4. ER - ...
https://tmu.pure.elsevier.com/en/publications/mechanism-of-the-acetylcholine-release-effect-of-cisapride-on-gui
Phenomenex HPLC Application #20243: Cisapride on Lux 5µm Cellulose-2 in RPPhenomenex HPLC Application #20243: Cisapride on Lux 5µm Cellulose-2 in RP
HPLC Application #20243: Cisapride on Lux 5µm Cellulose-2 in RP. Column used: Lux® 5 µm Cellulose-2, LC Column 250 x 4.6 mm, Ea Part#: 00G-4457-E0
https://www.phenomenex.com/Application/Detail/20243
CredibleMeds :: CisaprideCredibleMeds :: Cisapride
Updated April 12, 2000. Since 1995 several labeling changes for cisapride (Propulsid, Janssen Pharmaceutica) have been required by the Food and Drug Administration (FDA) following serious adverse effects that were reported through the MedWatch reporting program.56 This system is in place to ensure that new safety information is rapidly communicated to the health care field in order to improve patient care. During post-marketing surveillance, cisapride has been associated with prolongation of the QT interval on the electrocardiogram (ECG).4,7,16,56Subsequently, cisapride was associated with the potentially fatal arrhythmia torsades de pointes when taken with certain medications or in patients who have certain underlying conditions predisposing them to arrhythmias.7,14,34,50,55,56. A recent FDA analysis of 270 adverse event reports (including 70 fatalities) revealed that approximately 85% of these cases occurred in patients with identifiable risks such as drug-QTDrug interactions and underlying ...
https://www.crediblemeds.org/everyone/interaction-advisory/cisapride/
Cisapride does not alter gastric volume or pH in patients undergoing ambulatory surgery.
PURPOSE: To evaluate the efficacy of 20 mg cisapride p.o. in reducing residual gastric volume and pH in adult ambulatory surgical patients. METHODS: Using a prospective randomised double-blind controlled design, we administered either 20 mg cisapride
http://www.biomedsearch.com/nih/Cisapride-does-not-alter-gastric/10608215.html
What is cisapride? | Technology Trends
Cisapride is a gastroprokinetic agent, a drug which increases motility in the upper gastrointestinal tract. It acts directly as a serotonin 5-HT4 receptor agonist and indirectly as a parasympathomimetic. Stimulation of the serotonin receptors increases acetylcholine release in the enteric nervous system. It has been sold under the trade names Prepulsid (Janssen-Ortho) and Propulsid (in the U.S.). It was discovered by Janssen Pharmaceutica in 1980. In many countries, it has been either withdrawn from the market or had its indications limited because of side effects.. Read more about Cisapride. ...
https://www.primidi.com/what_is_cisapride
Cisapride | Project Gutenberg Self-Publishing - eBooks | Read eBooks onlineCisapride | Project Gutenberg Self-Publishing - eBooks | Read eBooks online
Cisapride: | | Cisapride | | | ||| | | | ... World Heritage Encyclopedia, the aggregation of the largest online encyclopedias available, and the most definitive collection ever assembled.
http://self.gutenberg.org/articles/eng/Cisapride
Flucostat, capsules
A single or multiple administration of fluconazole in a dose of 50 mg does not affect the metabolism of phenazone (Antipyrine) when they are taken once.. The simultaneous use of fluconazole with the following drugs is contraindicated:. Cisapride. With the simultaneous use of fluconazole and cisapride, undesirable reactions from the heart are possible, including ventricular arrhythmias, tachysystolic type pirouette (torsadedepointes). The use of fluconazole at a dose of 200 mg once a day and cisapride at a dose of 20 mg 4 times a day leads to a marked increase in plasma concentrations of cisapride and an increase in the QT interval on the ECG.. The simultaneous use of cisapride and fluconazole is contraindicated.. Terfenadine. With the simultaneous use of azole antifungal agents and terfenadine, serious arrhythmias may occur as a result of an increase in the QT interval. When taking fluconazole at a dose of 200 mg / day, an increase in the QT interval has not been established. However, the use ...
https://ruspills.com/flukostat-buy-online/
Cisapride - WikipediaCisapride - Wikipedia
Cisapride is a gastroprokinetic agent, a drug that increases motility in the upper gastrointestinal tract. It acts directly as a serotonin 5-HT4 receptor agonist and indirectly as a parasympathomimetic. Stimulation of the serotonin receptors increases acetylcholine release in the enteric nervous system. It has been sold under the trade names Prepulsid (Janssen-Ortho) and Propulsid (in the United States). It was discovered by Janssen Pharmaceutica in 1980. In many countries, it has been either withdrawn from the market or had its indications limited due to incidences of serious cardiac side-effects. The commercial preparations of this drug are the racemic mixture of both enantiomers of the compound. The (+) enantiomer itself has the major pharmacologic effects and does not induce many of the detrimental side-effects of the mixture.[1] ...
https://en.wikipedia.org/wiki/Cisapride
Liquid chromatographic determination including simultaneous on-cartridge separation of ranitidine cisapride drug combinations...
TY - JOUR. T1 - Liquid chromatographic determination including simultaneous on-cartridge separation of ranitidine cisapride drug combinations from paediatric plasma samples using an automated solid-phase extraction procedure. AU - Hare, L.G.. AU - Mitchel, D.S.. AU - Millership, Jeffrey. AU - Collier, Paul. AU - McElnay, James. AU - Shields, Michael. AU - Carson, Dennis. AU - Fair, R.. PY - 2004/7/5. Y1 - 2004/7/5. UR - http://www.scopus.com/inward/record.url?scp=2542481648&partnerID=8YFLogxK. M3 - Article. VL - 806. SP - 263. EP - 269. JO - Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. JF - Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. SN - 1570-0232. IS - 2. ER - ...
https://pure.qub.ac.uk/en/publications/liquid-chromatographic-determination-including-simultaneous-on-ca
Cisapride - Pet, Dog and Cat Medication and Prescription List | PetMDCisapride - Pet, Dog and Cat Medication and Prescription List | PetMD
Cisapride is given to cats and dogs to help quick passage of food through the digestive tract. Come to petMD for a complete list of pet medications and prescriptions.
https://www.petmd.com/pet-medication/cisapride
Cisapride Compounded - 1800PetMedsCisapride Compounded - 1800PetMeds
Buy Cisapride Compounded medication online at 1800PetMeds to help speed up your pets digestive process. Get free shipping on all orders more than $49.
https://www.1800petmeds.com/Cisapride+Compounded-prod90015.html
PCTs will check GP records before transfer | News Article | Pulse TodayPCTs will check GP records before transfer | News Article | Pulse Today
The addition of an H2RA to twice-daily PPI has been shown to be helpful, although loss of effect with time (tachyphylaxis) has been reported with H2RAs.. Combination therapy of prokinetics, such as cisapride, with acid suppressants has been shown to be efficacious. However, following its withdrawal from widespread use cisapride is now only available on a named-patient basis. Other prokinetics (eg domperidone and metoclopramide) have not been evaluated in this respect.. Baclofen has been shown to reduce TLOSR and is beginning to be used by some practitioners as adjunctive treatment.. Patients who do not respond to PPIs or who require long-term high doses of acid suppressants for symptom control should be referred for a specialist opinion. Endoscopic evaluation is often followed by 24 pH monitoring (off acid suppression for five days) to confirm excessive acid reflux, preferably with a close symptom-reflux association.. Manometric evaluation should be carried out at the same time to document LOS ...
http://www.pulsetoday.co.uk/pcts-will-check-gp-records-before-transfer/10916766.article
Cisapride oral suspensionCisapride oral suspension
Visit your doctor or health care professional for regular checks on your progress. For this medicine to work properly it is important to make lifestyle changes. Eat smaller meals, elevate the head of your bed 6 to 8 inches, avoid high-fat foods, chocolate, alcohol, smoking, caffeine and carbonated drinks.. If you have any fainting spells or rapid or irregular heartbeat, stop taking this drug immediately. Contact your health care professional right away for evaluation.. Do not drink grapefruit juice while you are taking this medicine. Grapefruit juice could increase your risk of having serious side effects from this medicine.. ...
http://livinghealthy.hawaiipacifichealth.org/RelatedItems/121,1240
Pager Forum - General, Beginners and Infants - cisapride/propulsid in Canada?
I stay at home now and Jedd goes to pre school. Ive picked up a new position at work that requires me to work late long hours sometimes. I will be scares for the next 4-5 days though.. I sub at my sons school all day Thurs. and Fri. I work my normal night job tomorrow night, Friday night. Then I captain several functions ( I work in a ballroom doing weddings and such) all day Saturday, think I will work from 7a.m. until around 1a.m. the next morning then I will have to turn around and work Sunday morning at 7a.m. until around 2:00p.m. I will be one tired puppy but the paycheck will be worth it. KIWM. FB is good for connecting to other parents. They put each other up in the status in order to gain you more people whos child has the same condition as yours does. I know about 50 or so EE parents. One of them went to a national convention, met alot of other EE Moms and Dads and they had a FB explsion!!! Great way to connect to others. My email is [email protected] That way you can find me. ...
http://www.reflux.org/reflux/webdsc01.nsf/vwID/VASV-89B3UK?OpenDocument
Cisapride tablets
About StayWell Our web site is designed to provide general information to educate users about programs and services, which may be available through our hospitals. The web site is not intended to provide medical advice nor should the information be used to attempt to determine the presence, absence or severity of any illness or medical condition which may be perceived or experienced by the user of this site. If you have or suspect you may have an illness or condition which you believe requires medical attention, we recommend you call your primary care physician. If you believe you are experiencing a medical emergency please call 911 (or your local medical emergency number) or seek immediate care from the nearest hospital Emergency Department. The provision of information to users of this web site is not intended as an inducement or to otherwise influence a persons decision to order or receive any item or service from a particular provider, practitioner or supplier that is reimbursable under ...
http://pbgmc.staywellsolutionsonline.com/library/encyclopedia/121,1239
Cisapride oral suspension
About StayWell Our web site is designed to provide general information to educate users about programs and services, which may be available through our hospitals. The web site is not intended to provide medical advice nor should the information be used to attempt to determine the presence, absence or severity of any illness or medical condition which may be perceived or experienced by the user of this site. If you have or suspect you may have an illness or condition which you believe requires medical attention, we recommend you call your primary care physician. If you believe you are experiencing a medical emergency please call 911 (or your local medical emergency number) or seek immediate care from the nearest hospital Emergency Department. The provision of information to users of this web site is not intended as an inducement or to otherwise influence a persons decision to order or receive any item or service from a particular provider, practitioner or supplier that is reimbursable under ...
http://pbgmc.staywellsolutionsonline.com/library/encyclopedia/121,1240
Therapy Alert - A Review Dr.T.R.RAMANUJAM. M.D., | MedindiaTherapy Alert - A Review Dr.T.R.RAMANUJAM. M.D., | Medindia
Cisapride is one of the frequently used prokinetic agent used in a variety of GIT disorders by virtue of its effects of its 5 HT receptor agonism.
http://www.medindia.net/articles/epharma4.asp
Prokinetic Agents - A Scientific Review of Drugs & Natural Sources in SIBOProkinetic Agents - A Scientific Review of Drugs & Natural Sources in SIBO
In this article, we break down what exactly prokinetics are, and why they can be a necessary part of treatment for many functional gut disorders.
https://sibosurvivor.com/prokinetic-agents/
Prokinetic Agents - A Scientific Review of Drugs & Natural Sources in SIBOProkinetic Agents - A Scientific Review of Drugs & Natural Sources in SIBO
In this article, we break down what exactly prokinetics are, and why they can be a necessary part of treatment for many functional gut disorders.
https://sibosurvivor.com/prokinetic-agents/?unapproved=22010&moderation-hash=2f990f5ab63ec4ae81b6fa6e69e8be32
Randomised controlled trial of cisapride in feed intolerance in preterm infants | ADC Fetal & Neonatal EditionRandomised controlled trial of cisapride in feed intolerance in preterm infants | ADC Fetal & Neonatal Edition
Many low birthweight premature babies will have feeding difficulties due to various factors related to their gut immaturity. Some of these factors include lower oesophageal sphincter pressure, delayed gastric emptying, and prolonged gastrointestinal transit time.1 Consequently, when these babies are fed by nasogastric tube, they often develop feed intolerance that is usually manifest by gastric aspirates, regurgitation, bile stained aspirates and/or abdominal distension. They may take several days to weeks to tolerate enteral feeds and are subjected to lengthy periods of parenteral nutrition.. Cisapride is a gastrointestinal prokinetic agent that acts by releasing acetylcholine from the nerve terminals of the gut. In children it increases lower oesophageal sphincter pressure,6 enhances gastric emptying,7-9 and increases intestinal transit time.10 11 It has been widely used in children for a variety of conditions including gastro-oesophageal reflux,6 12 13 intestinal pseudo-obstruction,14 15 and ...
http://fn.bmj.com/content/79/2/F110
PatientsLikeMe | Cisapride report for patients like youPatientsLikeMe | Cisapride report for patients like you
Cisapride: Find the most comprehensive real-world treatment information on Cisapride at PatientsLikeMe. 1 patients with fibromyalgia, multiple sclerosis, major depressive disorder, generalized anxiety disorder, diabetes type 2, post-traumatic stress disorder, systemic lupus erythematosus, bipolar disorder, Parkinsons disease, panic disorder, rheumatoid arthritis, high blood pressure (hypertension), myalgic encephalomyelitis/chronic fatigue syndrome, persistent depressive disorder (dysthymia), amyotrophic lateral sclerosis, epilepsy, migraine, hypothyroidism, osteoarthritis, traumatic brain injury, bipolar II disorder, attention deficit/hyperactivity disorder, asthma, social anxiety disorder, high cholesterol (hypercholesterolemia), irritable bowel syndrome, idiopathic pulmonary fibrosis, gastroesophageal reflux disease, bipolar I disorder or psoriasis currently take Cisapride.
https://www.patientslikeme.com/treatments/show/27122-cisapride-side-effects-and-efficacy
An Efficacy and Safety Study of Cisapride in Patients With Chronic Gastroparesis After Failure of Other Treatment Options -...An Efficacy and Safety Study of Cisapride in Patients With Chronic Gastroparesis After Failure of Other Treatment Options -...
This is a double-blind (neither the physician nor the patient will know the name of assigned treatment) study to determine the effectiveness of cisapride tablets compared to placebo tablets (a tablet identical in appearance to cisapride but does not contain active drug) in patients with a primary diagnosis of idiopathic gastroparesis (a disorder of unknown cause in which the stomach empties its contents very slowly into the small intestine for digestion. Symptoms of gastroparesis may include vomiting, nausea, early feeling of fullness after only a few bites of food, weight loss due to poor absorption of nutrients or low calorie intake, abdominal bloating, poor glycemic (blood sugar) control, lack of appetite, and pain in the stomach area. Patients will take study drug (one 10-mg tablet of cisapride, or one tablet of placebo), orally, 4 times a day, for a period of 8 weeks. Study drug will be taken approximately 15 minutes before each meal, and, with a beverage, before going to bed ...
https://clinicaltrials.gov/ct2/show/record/NCT01281540
An Efficacy and Safety Study of Cisapride in Patients With Chronic Gastroparesis After Failure of Other Treatment Options -...An Efficacy and Safety Study of Cisapride in Patients With Chronic Gastroparesis After Failure of Other Treatment Options -...
This is a double-blind (neither the physician nor the patient will know the name of assigned treatment) study to determine the effectiveness of cisapride tablets compared to placebo tablets (a tablet identical in appearance to cisapride but does not contain active drug) in patients with a primary diagnosis of idiopathic gastroparesis (a disorder of unknown cause in which the stomach empties its contents very slowly into the small intestine for digestion. Symptoms of gastroparesis may include vomiting, nausea, early feeling of fullness after only a few bites of food, weight loss due to poor absorption of nutrients or low calorie intake, abdominal bloating, poor glycemic (blood sugar) control, lack of appetite, and pain in the stomach area. Patients will take study drug (one 10-mg tablet of cisapride, or one tablet of placebo), orally, 4 times a day, for a period of 8 weeks. Study drug will be taken approximately 15 minutes before each meal, and, with a beverage, before going to bed ...
https://clinicaltrials.gov/show/NCT01281540
PRIME PubMed | Treating the symptoms of gastro-oesophageal reflux disease: a double-blind comparison of omeprazole and cisapridePRIME PubMed | Treating the symptoms of gastro-oesophageal reflux disease: a double-blind comparison of omeprazole and cisapride
PubMed journal article: Treating the symptoms of gastro-oesophageal reflux disease: a double-blind comparison of omeprazole and cisapride. Download Prime PubMed App to iPhone, iPad, or Android
https://www.unboundmedicine.com/medline/citation/9305487/Treating_the_symptoms_of_gastro_oesophageal_reflux_disease:_a_double_blind_comparison_of_omeprazole_and_cisapride_
Evaluation of the clinical efficacy of prokinetic drugs in the management of post-operative ileus: can retrospective data help...Evaluation of the clinical efficacy of prokinetic drugs in the management of post-operative ileus: can retrospective data help...
The objectives of the study were to determine whether retrospective data can be used to answer questions about the efficacy of prokinetic agents when used to treat horses with post-operative ileus (POI). We describe prevalence and mortality of POI with reference to treatment with four prokinetic agents. By combining data from two Hospitals a study population of 55 horses with POI following pedunculated lipoma obstruction (PLO) was established. Univariable and multivariable associations were determined between short term survival and potential explanatory variables. With death as outcome in multivariable models, breed and hospital were significantly associated with outcome but the use of prokinetic agents was not (P=0.15). However, sample size estimates indicate the low power of this study to detect differences in outcome. It was not possible definitively to evaluate the efficacy of prokinetics as treatment for POI following PLO using retrospective data. The data were suggestive of limited ...
http://epubs.surrey.ac.uk/826663/
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We were initially giving Bactrim and Periactin 2x/day, Metacam in the AM, and a probiotic with pellets midday. We noticed Danas GI system may have been a little iffy the first day or so post-op and the vet suggested we start Cisapride 2x/day which definitely helped. However, we noticed about 8 days post-op that shed lost about 2oz (50g) over the course of 2 days when we ran out of her initial Periactin. Vet suggested giving Periactin again (we had extra from Nutmeg) and adjusting Cisapride to once daily. At this point we are only a couple of days into the new routine (Bactrim/Periactin 2x, Metacam/probiotic/Cisapride 1x/day), but there have still been some fluctuations. In the 2 days shes been back on Periactin she went from 1159g to 1200g (her average is about 1175-1200). Today she was 1200 at 7:30am and somehow 1150 at 10:00pm (both weights taken before meds and veggies ...
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Prokinetic - definition of Prokinetic by The Free DictionaryProkinetic - definition of Prokinetic by The Free Dictionary
Define Prokinetic. Prokinetic synonyms, Prokinetic pronunciation, Prokinetic translation, English dictionary definition of Prokinetic. n. 1. The process of driving or propelling. 2. A driving or propelling force. pro·pul′sive , pro·pul′so·ry adj. Adj. 1. propulsive - having the power to...
https://www.thefreedictionary.com/Prokinetic
Serotonergic modulating drugs for functional gastrointestinal diseases - Spiller - 2002 - British Journal of Clinical...Serotonergic modulating drugs for functional gastrointestinal diseases - Spiller - 2002 - British Journal of Clinical...
This is a common condition in which patients suffer symptoms of upper gastric discomfort or pain in spite of normal endoscopy, ultrasound and other assessments. About one third of patients demonstrate delayed gastric emptying [49], another third demonstrate impaired gastric relaxation and about the same number demonstrate hypersensitivity to gastric distension [50, 51]. In general symptoms relate rather poorly to the abnormalities demonstrated, though Stanghellini et al.[49] found that severe vomiting and postprandial fullness together with female sex were predictive of delayed gastric emptying.. The demonstration of these abnormalities has encouraged the use of drugs to reverse them. In particular, initial interest focused on the role of cisapride, which had been shown to accelerate gastric emptying [52]. Cisapride also enhances postprandial gastric relaxation [53], whilst during fasting it increases fundal tone and perception of distension. These multiple actions may explain the somewhat ...
http://onlinelibrary.wiley.com/doi/10.1046/j.1365-2125.2002.01612.x/full
Which medications in the drug class Prokinetic Agents are used in the treatment of Constipation?Which medications in the drug class Prokinetic Agents are used in the treatment of Constipation?
Prokinetic AgentsProkinetics are promotility agents proposed for use in patients with severe constipation-predominant symptoms. Prucalopride (Motegrity)Prucalopride, a selective 5-hydroxytryptamine (s... more
https://www.medscape.com/answers/184704-25107/which-medications-in-the-drug-class-prokinetic-agents-are-used-in-the-treatment-of-constipation
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OT: this is a pretty good book and valuable reference overall, but they do discount the use of prokinetics (motility agents) in a number of diseases and disorders, including bloat/stasis. I have a very serious problem with that, since metoclopramide has been of great benefit to several of our pigs, and cisapride has been helpful to many on this board ...
http://www.guinealynx.info/forums/viewtopic.php?p=2152083
Stomach Inflammation (Atrophic) in Dogs | petMDStomach Inflammation (Atrophic) in Dogs | petMD
Treatment for atrophic gastritis, once properly diagnosed, does not require hospitalization. Treatment is home based. Medications can be prescribed in order to inhibit the secretion of gastric acid, and additional antibiotics will be necessary if infection with the Helicobacter spp bacteria is suspected. If vomiting persists, prokinetic agents (designed to enhance muscle activity in the gastrointestinal tract) may be prescribed as well.. ...
https://www.petmd.com/dog/conditions/digestive/c_dg_gastric_atrophic?page=2
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Investigating dynamic protocol-dependence of hERG potassium channel inhibition at 37 degrees C: Cisapride versus dofetilide :...Investigating dynamic protocol-dependence of hERG potassium channel inhibition at 37 degrees C: Cisapride versus dofetilide :...
INTRODUCTION. Pharmacological inhibition of cardiac potassium channels encoded by hERG (human ether-à-go-go-related gene) is associated with QT interval prolongation and torsades de pointes arrhythmia. Electrophysiological assays of hERG channel inhibition are integral to the safety testing of novel drug candidates. This study was conducted to compare, for the high affinity hERG inhibitors dofetilide and cisapride, hERG blockade between action potential (AP) and conventional (step and step-ramp) screening waveforms. Furthermore, it evaluated dynamic (pulse-by-pulse) protocol-dependence of hERG channel inhibition by these drugs.. METHODS. Whole-cell patch-clamp recordings were made at 37 degrees C from hERG-expressing HEK 293 cells. Half-maximal inhibitory concentrations (IC(50) values) for I(hERG) blockade were obtained using conventional voltage clamp and action potential clamp, using previously digitised ventricular and Purkinje fibre (PF) AP waveforms.. RESULTS. A more marked variation in ...
http://sro.sussex.ac.uk/42063/
Iberogast - WikipediaIberogast - Wikipedia
A 2004 meta-analysis comprising three randomized placebo-controlled studies with a total of 173 patients suggested that iberogast was more effective than placebo in relieving the most bothersome gastrointestinal symptom of functional dyspepsia as identified by each patient. Additionally, a single reference-controlled study was discussed, comparing iberogast to the prokinetic cisapride in the treatment of functional dyspepsia of the dysmotility type and finding no significant differences in efficacy or tolerability. This paper noted that, while iberogast seems to consistently provide symptomatic relief to patients, its efficacy is more evident with associated symptoms of gastro-oesophageal reflux or predominance of epigastric pain. It suggests a synergy of therapeutic mechanisms provided by the complex interactions between the GI tract and each individual component of iberogast. It also supports a promising safety profile for the formulation, but notes that its results must be confirmed ...
https://en.wikipedia.org/wiki/Iberogast
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A common polymorphism associated with antibiotic-induced cardiac arrhythmia. [PMID 14760488] Genetic variations of KCNQ1, KCNH2, SCN5A, KCNE1, and KCNE2 in drug-induced long QT syndrome patients. [PMID 16922724] Spectrum of pathogenic mutations and associated polymorphisms in a cohort of 44 unrelated patients with long QT syndrome. [PMID 19716085 ...
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Sam vs. Lupus: GastroparesisSam vs. Lupus: Gastroparesis
Sam, I am a newcomer to your blog. I have had gastroparesis, celiac, Crohns, and small intestinal pseudo obstruction for 5 years. Long before I was diagnosed with lupus/RA/who the hell knows. I know how much it sucks. I bought my domperidone from New Zealand (sp). I didnt find it to be helpful, but I really hope it is for you! Whatever you do, stay away from reglan! It has a host of really nasty side effects. You can try and get compassionate release for cisapride. Temple university in Philly is one of the leading places for gastric pacemakers. If you have any other questions or need someone to talk to that knows what youre going through post on her and I will send you my email privately ...
http://www.samvslupus.com/2013/02/gastroparesis_14.html?showComment=1398445151518
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Search - NeL.eduSearch - NeL.edu
RESULTS AND CONCLUSION: A total of 84 records were analysed. Baseline dominant frequency of slow waves was fully comparable in both groups. In Group I, there was a significant increase in dominant frequency after erythromycin administration (maximum between 240-360 min). There was a flat non-significant and delayed increase in dominant frequency after erythromycin administration in Group II. The difference between Group I and II at particular time intervals was not significant but a diverse trend was evident. EGG recording enables us to register a gastric myoelectrical effect of prokinetic drugs. Erythromycin induced a significant increase in the dominant frequency of slow waves. DSS caused toxic injury to the porcine gastrointestinal tract responsible for the delayed and weaker myoelectrical effect of erythromycin in experimental animals..... Read abstract Full text PDF ...
https://www.nel.edu/journal/search/?keywords=Gastrointestinal%20Diseases:chemica
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Faculty Results | UC Davis School of Veterinary Medicine
Principal Investigator, Effects of Cisapride on gastroesophageal reflux in mechanically ventilated dogs, (Principal Investigator), UC Davis: Center for Companion Animal Health. Co-Principal Investigator, Gastrointestinal transit after laparoscopic-assisted gastropexy, Culp W (VSR) (Principal Investigator), UC Davis: Center for Companion Animal Health. Co-Principal Investigator, Effect of surgical treatment of brachycephalic obstructor syndrome on the lower esophageal area of brachycephalic dogs with evidence of hiatal herniation and gastroesophageal reflux, Mayhew P (VSR) (Principal Investigator), American College of Veterinary Surgeons. Co-Principal Investigator, Effect of surgical treatment of brachycephalic obstructor syndrome on the lower esophageal area of brachycephalic dogs with evidence of hiatal herniation and gastroesophageal reflux, (Principal Investigator), UC Davis: Center for Companion Animal Health. Principal Investigator, Prevalence of zoonotic enteric pathogens in dogs attending ...
http://www.vetmed.ucdavis.edu/faculty/results.cfm?fid=14801
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Patients with chronic constipation benefit from treatment with 5-hydroxytryptamine 4 (5-HT4) receptor agonists. However, the first-generation 5-HT4 receptor agonists cisapride and tegaserod were withdrawn from the market owing to rare cardiovascular adverse events, which were not 5-HT4-receptor-related, but due to the lack of selectivity of these drugs. Here we report the nonclinical cardiovascular profile of the selective 5-HT4 receptor agonist prucalopride. To assess its non-5-HT4 receptor-mediated effects on cardiovascular electrophysiological parameters, in vitro studies were performed in human ether-a-go-go-related gene-transfected cells, guinea pig ventricular myocytes and papillary muscle preparations, rabbit and dog Purkinje fibers, and the Langendorff rabbit heart. In vivo experiments were performed in a rabbit model for drug-induced proarrhythmogenesis, in anesthetized guinea pigs, and anesthetized and conscious dogs. In addition, human platelet aggregation and coronary artery ...
http://jpet.aspetjournals.org/content/early/2017/11/27/jpet.117.244079
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Erythromycin for prokinesis: imprudent prescribing? | Critical Care | Full TextErythromycin for prokinesis: imprudent prescribing? | Critical Care | Full Text
Problems with antibiotic resistant bacteria are increasing in the hospital and particularly in the intensive care unit. Methicillin-resistant Staphylococcus aureus, Acinetobacter baumanii and extended spectrum beta-lactamase producing Gram-negative bacilli constitute a therapeutic and infection control challenge. Early enteral feeding improves survival in patients in the intensive care unit. Prokinetic agents are routinely used in patients with inappropriate gastrointestinal motility. The use of erythromycin at sub-therapeutic doses as a prokinetic agent is a cause of concern for the following reasons: it can increase the emergence and spread of antibiotic resistance and the likelihood of Clostridium difficile disease. The use of an antibiotic as a prokinetic agent does not constitute prudent antimicrobial prescribing and should be avoided. Alternative agents, whenever possible, should be used.
https://ccforum.biomedcentral.com/articles/10.1186/cc3956/metrics
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HERG K(+) channel, the genetic counterpart of rapid delayed rectifier K(+) current in cardiac cells, is responsible for many cases of inherited and drug-induced long QT syndromes. HERG has unusual biophysical properties distinct from those of other K(+) channels. While the conventional pulse protocols in patch-clamp studies have helped us elucidate these properties, their limitations in assessing HERG function have also been progressively noticed. We employed AP-clamp techniques using physiological action potential waveforms recorded from various regions of canine heart to study HERG function in HEK293 cells and identified several novel aspects of HERG function. We showed that under AP-clamp IHERG increased gradually with membrane repolarization, peaked at potentials around 20-30 mV more negative than revealed by pulse protocols and at action potential duration (APD) to 60%-70% full repolarization, and fell rapidly at the terminal phase of repolarization. We found that the rising phase of IHERG ...
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|p style=text-align: justify;|Levaquin is used for:|br /|Treating infections caused by certain bacteria. It may also be used to prevent or slow anthrax after exposure. Levaquin is a quinolone antibiotic. It works by killing sensitive bacteria.|br /|Do NOT use Levaquin if:|br /|• you are allergic to any ingredient in Levaquin or to any other quinolone antibiotic (eg, ciprofloxacin)|br /|• you have a certain type of irregular heartbeat (QT prolongation, long QT syndrome) or low blood potassium levels|br /|• you are taking cisapride or certain antiarrhythmics (eg, amiodarone, procainamide, quinidine, sotalol)|br /|Contact your doctor or health care provider right away if any of these apply to you.|br /|Before using Levaquin:|br /|Some medical conditions may interact with Levaquin . Tell your health care provider if you have any medical conditions, especially if any of the following apply to you:|br /|• if you are pregnant, planning to become pregnant, or are breast-feeding|br /|•
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Do not use this medication if you are allergic to erythromycin, or if you are also taking cisapride (Propulsid) or pimozide (Orap). If you have liver disease or myasthenia gravis, you may need a dose adjustment or special tests to safely take erythromycin. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Erythromycin can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby ...
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Do not use this medication if you are allergic to erythromycin, or if you are also taking cisapride (Propulsid) or pimozide (Orap). If you have liver disease or myasthenia gravis, you may need a dose adjustment or special tests to safely take erythromycin. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Erythromycin can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby ...
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Serial gastric ultrasound to evaluate gastric emptying after prokinetic therapy with domperidone and erythromycin in a surgical...Serial gastric ultrasound to evaluate gastric emptying after prokinetic therapy with domperidone and erythromycin in a surgical...
Fasting guidelines are used to prevent perioperative aspiration but they are only reliable in healthy elective patients. Point-of-care gastric ultrasound allows qualitative and quantitative evaluation of gastric contents at the bedside. This case report describes the use of serial gastric point-of-care ultrasound to evaluate the effect of prokinetic therapy with domperidone and erythromycin in an elective surgical patient with multiple comorbidities who presented with a full stomach. ...
https://repository.uantwerpen.be/link/irua/153090
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Cure Strategy (formerly, Serious Medicine Strategy): September 2009Cure Strategy (formerly, Serious Medicine Strategy): September 2009
Unfortunately, the FDA has never seen the choice in this fashion. FDA never keen on analyzing comparative risk or benefit of various treatments, saw risks in the use of digestive prokinetics that others simply did not see. In the case of Zelnorm, the last digestive prokinetic on the US market (which has the capability of regenerating digestive nerve and muscle tissue), FDA removed from the USA market due to a vague assessment of a 0.1% risk of cardiovascular side effects (i.e.- heart attack or angina), this was despite additional reports that the individuals who had these side effects had pre-existing cardiovascular conditions. With regard to a second prokinetic, Propulsid, Food and Drug removed it from the US market because 70 people suffered a cardiac condition known as prolonged QT syndrome, a condition that could have been diagnosed through the use of EKG. A final prokinetic, Domperidone which helps to restore proper swallowing function in individuals with paralysis never saw the light of ...
http://seriousmedicinestrategy.blogspot.com/2009_09_01_archive.html
Rhythm Presents Positive Phase 2 Study Results for Ghrelin Prokinetic Relamorelin (RM-131) inRhythm Presents Positive Phase 2 Study Results for Ghrelin Prokinetic Relamorelin (RM-131) in
BOSTON, May 6, 2014 /PRNewswire/ -- Rhythm Presents Positive Phase 2 Study Results for Ghrelin Prokinetic Relamorelin (RM-131) in Diabetic Gastroparesis.
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Acotiamide hydrochloride hydrate Manufacturer,Supplier and ExporterAcotiamide hydrochloride hydrate Manufacturer,Supplier and Exporter
ANGLE BIO PHARMA, We are Manufacturer,Supplier and Exporter of Acotiamide hydrochloride hydrate based in Ahmedabad, Gujarat, India.
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Medical Pharmacology Chapter 27: Gastrointestinal Pharmacology Practice QuestionsMedical Pharmacology Chapter 27: Gastrointestinal Pharmacology Practice Questions
An example of an effective prokinetic agent would be represented by muscarinic receptor agonist or by inhibitors of the enzyme acetylcholinesterase ...
https://www.pharmacology2000.com/Gastrointestinal/questionset2711/questionset2711.htm
Magaldrate 400mg+Simethicone 20mg 5 ml - 170 ml Manufacturer, Supplier, ExporterMagaldrate 400mg+Simethicone 20mg 5 ml - 170 ml Manufacturer, Supplier, Exporter
We, Accretion Pharmaceuticals is one of the prominent leading Manufacturer, Supplier and Exporter of Magaldrate 400mg+Simethicone 20mg 5 ml - 170 ml, We own a Revised Schedule M license and a plant facility is being constructed by us for the ease of manufacturing and it is under the consent of WHO guidelines from Sanand, Gujarat, India
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Pepto-Bismol Original Strength and simethicone Drug Interactions - Drugs.comPepto-Bismol Original Strength and simethicone Drug Interactions - Drugs.com
View drug interactions between Pepto-Bismol Original Strength and simethicone. These medicines may also interact with certain foods or diseases.
https://www.drugs.com/drug-interactions/pepto-bismol-original-strength-with-simethicone-391-17818-2065-0.html
Gas-X (simethicone) dose, indications, adverse effects, interactions... from PDR.netGas-X (simethicone) dose, indications, adverse effects, interactions... from PDR.net
PDR Drug Summaries are concise point-of-care prescribing, dosing and administering information to help phsyicans more efficiently and accurately prescribe in their practice PDR's drug summaries are available free of charge and serve as a great resource for US based MDs, DOs, NPs and PAs in patient practice
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CisaprideCisapride
... cisapride", issued 1999-Sep-21 Maclennan S, Augood C, Cash-Gibson L, Logan S, Gilbert RE (April 2010). "Cisapride treatment for ... Cisapride is still available in the United States and Canada for use in animals, and is commonly prescribed by veterinarians to ... Cisapride has been used for the treatment of gastroesophageal reflux disease (GERD). There is no evidence it is effective for ... Cisapride is a gastroprokinetic agent, a drug that increases motility in the upper gastrointestinal tract. It acts directly as ...
https://en.wikipedia.org/wiki/Cisapride
ConstipationConstipation
Cisapride is widely available in third world countries, but has been withdrawn in most of the west. It has not been shown to ... Aboumarzouk, Omar M; Agarwal, Trisha; Antakia, Ramez; Shariff, Umar; Nelson, Richard L (19 January 2011). "Cisapride for ...
https://en.wikipedia.org/wiki/Constipation
PhenylpropanolaminePhenylpropanolamine
"Unsafe Drugs- nimesulide, Cisapride, Phenylpropanolamine Banned". 27 January 2011. "Madras High Court Revokes Ban on ...
https://en.wikipedia.org/wiki/Phenylpropanolamine
MetoclopramideMetoclopramide
... is a substituted benzamide; cisapride and mosapride are structurally related. Metoclopramide was first described ...
https://en.wikipedia.org/wiki/Metoclopramide
Grapefruit-drug interactionsGrapefruit-drug interactions
Gross AS, Goh YD, Addison RS, Shenfield GM (April 1999). "Influence of grapefruit juice on cisapride pharmacokinetics". ... Examples of such known CYP3A4 inhibitors include cisapride (Propulsid), erythromycin, itraconazole (Sporanox), ketoconazole ( ...
https://en.wikipedia.org/wiki/Grapefruit–drug_interactions
Drug of last resortDrug of last resort
... such as cisapride. Aminoglycosides - their use is extremely restricted due to risk of hearing loss and kidney damage; ... Cisapride - used for severe gastroesophageal reflux disease (GERD); carries risk of heart arrhythmias; Clomethiazole - a ...
https://en.wikipedia.org/wiki/Drug_of_last_resort
ParacetamolParacetamol
AUC increases are also observed with nizatidine and cisapride. The effect is explained by these drugs inhibiting ...
https://en.wikipedia.org/wiki/Paracetamol
DiazepamDiazepam
Cisapride may enhance the absorption, and therefore the sedative activity, of diazepam. Small doses of theophylline may inhibit ... Bateman DN (1986). "The action of cisapride on gastric emptying and the pharmacodynamics and pharmacokinetics of oral diazepam ...
https://en.wikipedia.org/wiki/Diazepam
Intestinal pseudo-obstructionIntestinal pseudo-obstruction
Prucalopride, pyridostigmine, metoclopramide, cisapride, erythromycin and octreotide are medications that aim to enhance ...
https://en.wikipedia.org/wiki/Intestinal_pseudo-obstruction
5-HT4 receptor5-HT4 receptor
BIMU-8 Cisapride CJ-033,466 - partial agonist ML-10302 Mosapride Prucalopride Renzapride RS-67506 RS-67333 - partial agonist ... "Overexpression of serotonin4 receptors in cisapride-responsive adrenocorticotropin-independent bilateral macronodular adrenal ...
https://en.wikipedia.org/wiki/5-HT4_receptor
Prokinetic agentProkinetic agent
As such, the relatively poor selectivity profile of cisapride versus other receptors (especially hERG [human ether-a-go-go K+] ... Some of these prokinetic agents, such as mosapride and cisapride, classic benzamides, have only moderate affinity for 5HT4 ... Benzamide Cisapride Domperidone Itopride Mosapride Metoclopramide Prucalopride Renzapride Tegaserod Mitemcinal Levosulpiride ...
https://en.wikipedia.org/wiki/Prokinetic_agent
SimeticoneSimeticone
"A randomized placebo-controlled trial of simethicone and cisapride for the treatment of patients with functional dyspepsia". ...
https://en.wikipedia.org/wiki/Simeticone
Sir William Arbuthnot Lane, 1st BaronetSir William Arbuthnot Lane, 1st Baronet
Medical treatment with laxatives, enemas and prokinetic agents, such as cisapride, does not relieve the burdensome symptoms. ...
https://en.wikipedia.org/wiki/Sir_William_Arbuthnot_Lane,_1st_Baronet
Serotonin receptor agonistSerotonin receptor agonist
Cisapride and tegaserod are 5-HT4 receptor partial agonists that were used to treat disorders of gastrointestinal motility. ...
https://en.wikipedia.org/wiki/Serotonin_receptor_agonist
MosaprideMosapride
... drug information - Drugs Update India Kii Y, Ito T (May 1997). "Effects of 5-HT4-receptor agonists, cisapride, ...
https://en.wikipedia.org/wiki/Mosapride
CJ-033466CJ-033466
Toga T, Kohmura Y, Kawatsu R (October 2007). "The 5-HT(4) agonists cisapride, mosapride, and CJ-033466, a Novel potent compound ... In animal tests it stimulated gastrointestinal motility with 30 times the potency of cisapride, and with lower affinity for the ...
https://en.wikipedia.org/wiki/CJ-033466
ItoprideItopride
The affinity of cisapride for 5-HT4 receptors in the heart has been implicated in the undesirable cardiac effects of cisapride ... Itopride belongs to the same benzamide group as cisapride, a drug found to affect QT interval and possibly predispose those ... Moreover, itopride has no affinity for the 5-HT4 receptors, unlike other benzamides such as cisapride and mosapride, which are ... unlike cisapride and mosapride, as it is metabolized by a different enzyme set. New molecular studies on guinea pig ventricular ...
https://en.wikipedia.org/wiki/Itopride
Terence Young (politician)Terence Young (politician)
Johnson prescription drug cisapride (brand name in Canada: Prepulsid). Young became a consumer advocate after this incident, ...
https://en.wikipedia.org/wiki/Terence_Young_(politician)
ErythromycinErythromycin
Other examples include terfenadine (Seldane, Seldane-D), astemizole (Hismanal), cisapride (Propulsid, withdrawn in many ...
https://en.wikipedia.org/wiki/Erythromycin
VelusetragVelusetrag
... to earlier generation 5-HT agonists like cisapride and tegaserod. In a large clinical trial in patients with chronic idiopathic ...
https://en.wikipedia.org/wiki/Velusetrag
5-HT3 antagonist5-HT3 antagonist
Certain prokinetic drugs such as cisapride, renzapride and metoclopramide, although not 5-HT3 antagonists proper, possess some ...
https://en.wikipedia.org/wiki/5-HT3_antagonist
Chiral switchChiral switch
... and cisapride to norcisapride. A summary is presented in the table below. Chiral drugs Chirality Enantiopure drug Chiral ...
https://en.wikipedia.org/wiki/Chiral_switch
AtazanavirAtazanavir
... cisapride, St. John's wort, lovastatin, simvastatin, sildenafil, indinavir, or nevirapine. Common side effects include: nausea ...
https://en.wikipedia.org/wiki/Atazanavir
SucralfateSucralfate
... cisapride + sucralfate can significantly improve symptoms and quality of life and was more cost-effective than ranitidine ...
https://en.wikipedia.org/wiki/Sucralfate
KetoconazoleKetoconazole
... cisapride, nisoldipine, dofetilide, pimozide And is not recommended: carbamazepine, phenytoin gastric acid suppressants: ...
https://en.wikipedia.org/wiki/Ketoconazole
ClarithromycinClarithromycin
... cisapride, pimozide, astemizole, terfenadine, ergotamine, ticagrelor, ranolazine or dihydroergotamine is not recommended. It ...
https://en.wikipedia.org/wiki/Clarithromycin
List of MeSH codes (D03)List of MeSH codes (D03)
... cisapride MeSH D03.383.621.147 - clopamide MeSH D03.383.621.160 - cyproheptadine MeSH D03.383.621.160.500 - loratadine MeSH ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D03)
PrucalopridePrucalopride
... differs from other 5-HT4 agonists such as tegaserod and cisapride, which at therapeutic concentrations also ...
https://en.wikipedia.org/wiki/Prucalopride
Parasympathomimetic drugParasympathomimetic drug
A Irreversible cholinesterase inhibitors Echothiophate Isoflurophate Malathion ACh release promoters Alpha GPC Cisapride ...
https://en.wikipedia.org/wiki/Parasympathomimetic_drug
List of MeSH codes (D02)List of MeSH codes (D02)
... cisapride MeSH D02.065.277.194 - deet MeSH D02.065.277.225 - dinitolmide MeSH D02.065.277.431 - hippurates MeSH D02.065.277.431 ... cisapride MeSH D02.241.223.100.120.230 - deet MeSH D02.241.223.100.120.240 - dinitolmide MeSH D02.241.223.100.120.460 - ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D02)
Cisapride: MedlinePlus Drug InformationCisapride: MedlinePlus Drug Information
Cisapride: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Cisapride comes as a tablet and liquid to take by mouth. Cisapride usually is taken four times a day, 15 minutes before meals ... Before taking cisapride,. *tell your doctor and pharmacist if you are allergic to cisapride or any other drugs. ... Take cisapride exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. ...
https://medlineplus.gov/druginfo/meds/a694006.html
Browsing by Subject CisaprideBrowsing by Subject "Cisapride"
JavaScript is disabled for your browser. Some features of this site may not work without it ...
https://extranet.who.int/iris/restricted/browse?authority=Cisapride&type=mesh
Cisapride disposition in neonates and infants: in vivo reflection of cytochrome P450 3A4 ontogenyCisapride disposition in neonates and infants: in vivo reflection of cytochrome P450 3A4 ontogeny
... of cisapride CL/F in neonates and young infants was nonrenal in nature; (3) CL/F of cisapride in neonates and infants noted in ... 1) In neonates and infants, cisapride absorption and metabolism to its primary metabolite, norcisapride, were developmentally ... of cisapride CL/F in neonates and young infants was nonrenal in nature; (3) CL/F of cisapride in neonates and infants noted in ... Cisapride disposition in neonates and infants: in vivo reflection of cytochrome P450 3A4 ontogeny Clin Pharmacol Ther. 2003 Oct ...
https://pubmed.ncbi.nlm.nih.gov/14534518/
Thông tin thuốc của Cisapride | MIMS VietnamThông tin thuốc của Cisapride | MIMS Vietnam
Cisapride: Search drug information, interaction, images & medical diagnosis. The most comprehensive database of medicines ... Cisapride increases the GI absorption of cimetidine and ranitidine. Grapefruit juice increases bioavailability of cisapride, ... Thông báo miễn trừ trách nhiệm: Thông tin này được MIMS biên soạn một cách độc lập dựa trên thông tin của Cisapride từ nhiều ... Description: Cisapride increases GI motility by enhancing the release of acetylcholine at the myenteric plexuses in the gut ...
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Should cisapride have been blacklisted? | ADC Fetal & Neonatal EditionShould cisapride have been "blacklisted"? | ADC Fetal & Neonatal Edition
You need to be signed in to access email alerts. If you have an account log in with your user name and password. If you dont have an account you can just enter your email address in the email box below ...
https://fn.bmj.com/content/82/1/F3.alerts
Postmarketing reports of QT prolongation and ventricular arrhythmia in association with cisapride and Food and Drug...Postmarketing reports of QT prolongation and ventricular arrhythmia in association with cisapride and Food and Drug...
The risk of fatal arrhythmia with cisapride was believed to outweigh the benefit for the approved indication, treatme … ... Postmarketing reports and pharmacokinetic and electrophysiological data provided evidence that cisapride is associated with the ... Factors that suggested an association with cisapride included a temporal relationship between use of cisapride and arrhythmia, ... Results: While cisapride was being marketed from 1993-1999, the FDA received reports of the following patients: 117 who ...
https://pubmed.ncbi.nlm.nih.gov/11419817/?dopt=Abstract
IMSEAR at SEARO: Cisapride.
Mangal N, Singh J, Sharma U, Patni T. Cisapride. Indian Pediatrics. 1995 Oct; 32(10): 1124-6. ...
https://imsear.searo.who.int/handle/123456789/15782
Effects of ranitidine and cisapride on acid reflux and oesophageal motility in patients with reflux oesophagitis: a 24 hour...
Effects of ranitidine and cisapride on acid reflux and oesophageal motility in patients with reflux oesophagitis: a 24 hour ...
https://experts.mcmaster.ca/display/publication1533838
Appendix -- Characteristics of Available Antiretroviral DrugsAppendix -- Characteristics of Available Antiretroviral Drugs
Indinavir is not recommended for concurrent use with antihistamines (e.g., astemizole or terfenadine); cisapride; ergot ... Nelfinavir is not recommended for concurrent use with antihistamines (e.g., astemizole or terfenadine); cisapride; ergot ... Saquinavir is not recommended for concurrent use with antihistamines (e.g., astemizole or terfenadine); cisapride; ergot ... cisapride; sedative-hypnotics (e.g., alprazolam, clorazepate, diazepam, estazolam, flurazepam hydrochloride, midazolam, ...
https://www.cdc.gov/mmwr/preview/mmwrhtml/00052176.htm
Acute Intermittent Porphyria Clinical Presentation: History, Physical ExaminationAcute Intermittent Porphyria Clinical Presentation: History, Physical Examination
Acute intermittent porphyria (AIP) is one of the porphyrias, a group of diseases involving defects in heme metabolism and that results in excessive secretion of porphyrins and porphyrin precursors. AIP manifests itself by abdomen pain, neuropathies, and constipation, but, unlike most types of porphyria, patients with AIP do not have a rash.
https://www.medscape.com/answers/205220-182853/what-causes-acute-intermittent-porphyria-aip
Cisapride For Cats: Dosage, Safety & Side Effects - All About CatsCisapride For Cats: Dosage, Safety & Side Effects - All About Cats
Cisapride is a medication used to encourage normal emptying and forward motion of digestive contents. Learn more about how it ... What Does Cisapride Do For Cats?. Cisapride has been found to be useful in treating cats with recurrent constipation, and for ... Why is Cisapride Banned?. In people, cisapride was found to cause a certain type of heart rhythm disorder, or arrhythmia, ... About Cisapride For Cats. Cisapride is classified as a prokinetic or promotility agent. It is a serotonin (5-HT4)-receptor ...
https://allaboutcats.com/cisapride-for-cats
DailyMed - CLARITHROMYCIN tablet, film coatedDailyMed - CLARITHROMYCIN tablet, film coated
Cisapride Contraindicated. Cisapride:[See Contraindications (4.2)] Lipid-lowering agents: Lomitapide. Lovastatin Simvastatin ... 4.2 Cisapride and Pimozide. Concomitant administration of Clarithromycin tablets with cisapride and pimozide is contraindicated ... 4.2 Cisapride and Pimozide 4.3 Cholestatic Jaundice/Hepatic Dysfunction 4.4 Colchicine 4.5 Lomitapide, Lovastatin, and ... There have been postmarketing reports of drug interactions when clarithromycin is co- administered with cisapride or pimozide, ...
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=cde51c9f-f7b8-413f-8b8e-e56370cd5754
Hereditary Coproporphyria Clinical Presentation: History, Physical ExaminationHereditary Coproporphyria Clinical Presentation: History, Physical Examination
Hereditary coproporphyria is one of the porphyrias, a group of diseases that involves defects in heme metabolism and that results in excessive secretion of porphyrins and porphyrin precursors. Inheritance is autosomal (usually autosomal dominant, but sometimes autosomal recessive).
https://emedicine.medscape.com/article/205374-clinical
Appendix -- Characteristics of Available Antiretroviral DrugsAppendix -- Characteristics of Available Antiretroviral Drugs
Indinavir is not recommended for concurrent use with antihistamines (e.g., astemizole or terfenadine); cisapride; ergot ... Nelfinavir is not recommended for concurrent use with antihistamines (e.g., astemizole or terfenadine); cisapride; ergot ... Saquinavir is not recommended for concurrent use with antihistamines (e.g., astemizole or terfenadine); cisapride; ergot ... cisapride; or warfarin. * DLV clearance is increased, resulting in substantially reduced concentrations of DLV, with concurrent ...
https://wonder.cdc.gov/wonder/prevguid/m0052176/m0052176.asp
Fluoxetine (Oral Route) Before Using - 妙佑医疗国际Fluoxetine (Oral Route) Before Using - 妙佑医疗国际
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.. Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.. ...
https://www.mayoclinic.org/zh-hans/drugs-supplements/fluoxetine-oral-route/before-using/drg-20063952
Listing of Drugs Currently Regulated as New Drugs (The New Drugs List) - Canada.caListing of Drugs Currently Regulated as New Drugs (The New Drugs List) - Canada.ca
Health Canada list representing substances and formulations which have been assessed on the basis of an application to market or further to promotion of products for medicinal purposes where safety and efficacy for such purposes have not been established
https://www.canada.ca/en/health-canada/services/drugs-health-products/drug-products/applications-submissions/guidance-documents/listing-drugs-currently-regulated-new-drugs.html
Mylan-Paliperidone Advanced Patient Information - Drugs.comMylan-Paliperidone Advanced Patient Information - Drugs.com
Detailed drug Information for Mylan-Paliperidone. Includes common brand names, drug descriptions, warnings, side effects and dosing information.
https://www.drugs.com/cons/mylan-paliperidone.html
Octreotide: Generic, Uses, Side Effects, Dosages, Interaction, WarningsOctreotide: Generic, Uses, Side Effects, Dosages, Interaction, Warnings
Octreotide is used to treat severe watery diarrhea and sudden reddening of the face and neck caused by certain types of tumors. Learn about side effects, dosages, drug interactions, and more.
https://www.rxlist.com/consumer_octreotide_sandostatin/drugs-condition.htm
Bactimycin 150 MG Tablet - Uses, Dosage, Side Effects, Price, Composition | PractoBactimycin 150 MG Tablet - Uses, Dosage, Side Effects, Price, Composition | Practo
Bactimycin 150 MG Tablet is a macrolide antibiotic used to treat bacterial infections of the throat, airways, tonsils, lungs, skin and urinary tract- the kidneys, bladder, ureters, or urethra. This medicine kills or stops the growth of bacteria causing the infection. It is not effective against infections caused by viruses. Common side effects of Bactimycin 150 MG Tablet are diarrhoea, stomach pain, headache, changes in sense of taste, weakness, nausea, and vomiting. Use it cautiously in individuals with liver problems. It should only be used to treat or prevent infections that are caused by bacteria. Once an antibiotic is started, it is always recommended to finish the entire course of treatment. You can take Bactimycin 150 MG Tablet on an empty stomach at least 15 minutes before food. For the ease of remembering, take this antibiotic at around the same time every day. Buy Bactimycin 150 MG Tablet Online. Know uses, side effects, dosage, contraindications, substitutes, benefit, interactions, purpose
https://www.practo.com/medicine-info/bactimycin-150-mg-tablet-15799
Preventable Adverse Drug Reactions: A Focus on Drug Interactions | FDAPreventable Adverse Drug Reactions: A Focus on Drug Interactions | FDA
Contraindicated use of cisapride: impact of food and drug administration regulatory action. JAMA 2000;284(23):3036-3039. ... on prescription errors with cisapride.6 These findings should reinforce the need for the health care practitioner to develop ... For terfenadine, as well as astemizole and cisapride, recognition and reporting of torsades de pointes in association with the ... These include a wide range of important medications including cyclosporine and HIV protease inhibitors, as well as cisapride ( ...
https://www.fda.gov/drugs/drug-interactions-labeling/preventable-adverse-drug-reactions-focus-drug-interactions
DeCS - Termos NovosDeCS - Termos Novos
CISAPRIDE. CISAPRIDA. COLATO DE SÓDIO. SODIUM CHOLATE. COLATO DE SODIO. COLATOS. CHOLATES. COLATOS. ...
https://decs.bvs.br/P/decswebpage2p.htm
Genvoya - Uses, Side Effects, Interactions - MedBroadcast.comGenvoya - Uses, Side Effects, Interactions - MedBroadcast.com
Genvoya: This is a combination product that contains 4 medications in 1 tablet: cobicistat, emtricitabine, elvitegravir, and tenofovir alafenamide. These 4 medications are used in combination to treat human immunodeficiency virus (HIV) infection. Together, these medications are antiretroviral medications. This combination product is used to treat HIV-1 infections for adults and children (who weigh more than 25 kg) who have not developed resistance to any of these individual medications for HIV. HIV is the virus responsible for acquired immune deficiency syndrome (AIDS). This product is not intended to be used in combination with any other product.
https://www.medbroadcast.com/drug/getdrug/genvoya
Apo-Erythro-S - Uses, Side Effects, Interactions - MedBroadcast.comApo-Erythro-S - Uses, Side Effects, Interactions - MedBroadcast.com
is taking astemizole*, terfenadine, cisapride, pimozide, ergotamine, or dihydroergotaime. *Astemizole, terfenadine, and ...
https://medbroadcast.com/drug/getdrug/apo-erythro-s
Loratadine - StatPearls - NCBI BookshelfLoratadine - StatPearls - NCBI Bookshelf
Paakkari I. Cardiotoxicity of new antihistamines and cisapride. Toxicol Lett. 2002 Feb 28;127(1-3):279-84. [PubMed: 12052668] ...
https://www.ncbi.nlm.nih.gov/books/NBK542278/
Anorexia Nervosa Treatment & Management: Approach Considerations, Pharmacologic Therapy, Types of Psychological TherapyAnorexia Nervosa Treatment & Management: Approach Considerations, Pharmacologic Therapy, Types of Psychological Therapy
A controlled trial of cisapride in anorexia nervosa. Int J Eat Disord. 1995 May. 17(4):347-57. [QxMD MEDLINE Link]. ...
https://emedicine.medscape.com/article/912187-treatment
Online Ventolin prescription * Buy from Canadian PharmacyOnline Ventolin prescription * Buy from Canadian Pharmacy
cisapride. *diuretics. *medicines for colds. *medicines for depression or for emotional or psychotic conditions ...
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DAVELEN - Free shipping | ChewyDAVELEN - Free shipping | Chewy
Shop Chewy for low prices and the best DAVELEN! We carry a large selection and the top brands like Chewy Exclusives, Frisco, and more. Find everything you need in one place. FREE shipping on orders $49+ and the BEST customer service!
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Assessment of meal induced gastric accommodation by a satiety drinking test in health and in severe functional dyspepsia | GutAssessment of meal induced gastric accommodation by a satiety drinking test in health and in severe functional dyspepsia | Gut
Influence of cisapride on gastric tone and on the perception of gastric distension. Aliment Pharmacol Ther1998;12:761-6. ... Both sumatriptan and cisapride were shown to enhance accommodation to a meal, and erythromycin was shown to inhibit ... Cisapride significantly enhanced the amount of food ingested from 1444 (78) kcal (963 (52) ml) to 1684 (93) kcal (1123 (62) ml ... Tack J, Coremans G, Janssens J. A risk-benefit appraisal of cisapride in the treatment of gastrointestinal disorders. Drug Saf ...
https://gut.bmj.com/content/52/9/1271?ijkey=12f90e20280567f84a0b63ecfe63a6ba2006642c&keytype2=tf_ipsecsha
PimozideAstemizolePropulsidMetoclopramideErythromycinMotilityGrapefruitMegacolonStimulatesProkineticSerious irregularRanitidineArrhythmiaPharmacokineticMedicationMedicationsInfantsNighttime heartburnDoctor or pharmacistAllergicPrecautionsPregnantDrugConstipationTreatmentsTabletsLiquid to take by mouthSideAssociationHelpsHeartTestsTotal
Pimozide3
  • Biaxin may interact with cisapride, pimozide, ergot medicines and result in life-threatening heart rhythm disorders. (pcostracker.app)
  • Concomitant administration of clarithromycin and any of the following drugs is contra-indicated: cisapride, pimozide and terfenadine. (nafarma.com)
  • Elevated cisapride, pimozide and terfenadine levels have been reported in patients receiving either of these drugs and clarithromycin concomitantly. (nafarma.com)
Astemizole2
  • Recognition and reporting of this arrhythmia in association with terfenadine, astemizole (Hismanal), cisapride (Propulsid), grepafloxacin (Raxar), and mibefradil (Posicor) ultimately led to the removal of these medications from the market. (fda.gov)
  • Astemizole, terfenadine, and cisapride are no longer marketed in Canada. (medbroadcast.com)
Propulsid2
  • Cisapride is sold under the brand name Propulsid, and it is used in the treatment of gastric reflux, which is usually experienced as heartburn. (medsol.info)
  • Other medicines include metoclopramide (brand name: Reglan) and cisapride (brand name: Propulsid). (aafp.org)
Metoclopramide3
  • Further medication included propulsive agents (metoclopramide 20 mgs i.v. every 6 h, cisapride 10 cc p.o. every 6 h) and immunosuppression (tacrolimus 0.05 mgs/kg or cyclosporine 4 mgs/kg, ATG 5 mgs/kg, prednisolone 20 mgs/day, mycophenolatmofetile 2 g/day). (biomedcentral.com)
  • Certain medicines should not be taken while taking metoclopramide and cisapride. (aafp.org)
  • Metoclopramide, cisapride may decrease the inhibitory effect of the drug Scopolan on the digestive tract. (herbapol.pl)
Erythromycin1
  • Pharmacological agents (sumatriptan, cisapride, erythromycin) affected the satiety test according to their effect on accommodation. (bmj.com)
Motility3
  • Cisapride increases GI motility by enhancing the release of acetylcholine at the myenteric plexuses in the gut plain muscle. (mims.com)
  • Effects of ranitidine and cisapride on acid reflux and oesophageal motility in patients with reflux oesophagitis: a 24 hour ambulatory combined pH and manometry study. (mcmaster.ca)
  • Because cisapride stimulates motility and pushes digestive contents along, it is extremely important that the medication is only used in the absence of a current obstruction. (allaboutcats.com)
Grapefruit2
  • Do not drink grapefruit juice while taking cisapride. (medlineplus.gov)
  • Grapefruit juice increases bioavailability of cisapride, avoid concomitant use. (mims.com)
Megacolon2
  • Cisapride has been found to be useful in treating cats with recurrent constipation, and for cats with megacolon. (allaboutcats.com)
  • Megacolon can be reversed with cisapride and an enema. (veterinarypracticenews.com)
Stimulates1
  • Medications such as cisapride, which stimulates the gut to move, can be helpful. (vethelpdirect.com)
Prokinetic2
  • Cisapride, a prokinetic agent and substrate for cytochrome P450 (CYP) 3A4, has been used to treat neonates and infants with feeding intolerance and apnea or bradycardia associated with gastroesophageal reflux. (nih.gov)
  • Cisapride is classified as a prokinetic or promotility agent. (allaboutcats.com)
Serious irregular2
  • Cisapride may cause serious irregular heart beats, which can lead to death. (medlineplus.gov)
  • Cisapride may cause some other serious irregular symptoms. (medsol.info)
Ranitidine1
  • Cisapride increases the GI absorption of cimetidine and ranitidine. (mims.com)
Arrhythmia4
  • The FDA analyzed reports of patients who developed QT prolongation, torsades de pointes, and ventricular arrhythmia in association with the use of cisapride to assess probable etiology and risk factors. (nih.gov)
  • Factors that suggested an association with cisapride included a temporal relationship between use of cisapride and arrhythmia, the absence of identified risk factors and other explanations for arrhythmia in some patients, and cases of positive dechallenge and rechallenge. (nih.gov)
  • The risk of fatal arrhythmia with cisapride was believed to outweigh the benefit for the approved indication, treatment of nocturnal heartburn due to gastroesophageal reflux disease, leading to the drug's discontinuation in the United States. (nih.gov)
  • In people , cisapride was found to lead to a certain abnormal heart rhythm, or arrhythmia, prompting it to be removed as a drug for human use. (allaboutcats.com)
Pharmacokinetic3
  • This known developmental delay in the expression of CYP3A4 prompted us to conduct a classical open-label pharmacokinetic study of cisapride in neonates and young infants. (nih.gov)
  • Cisapride and norcisapride were quantitated from plasma by HPLC-tandem mass spectrometry and pharmacokinetic data determined (n = 32) by noncompartmental methods. (nih.gov)
  • Postmarketing reports and pharmacokinetic and electrophysiological data provided evidence that cisapride is associated with the occurrence of QT prolongation and torsades de pointes. (nih.gov)
Medication9
  • Cisapride can also be used for some other purposes that are not mentioned in this document or in this medication guide. (medsol.info)
  • Whether you are taking cisapride or not, always talk to your doctor or pharmacist first about this medication. (medsol.info)
  • Your healthcare professionals will check your body's response towards this medication through some lab tests and don't ever try to take less or more of cisapride than prescribed by your healthcare professionals. (medsol.info)
  • Ask your doctor or pharmacist for more information about the prescribed treatments for other diseases of cisapride medication because cisapride should not be prescribed for other uses. (medsol.info)
  • This medication only uses serious side effects because people that are using cisapride medication have some serious side effects. (medsol.info)
  • Don't use this medication without your doctor's prescription, Doctors will suggest cisapride medication by judging the benefit to you is greater than the risk of side effects. (medsol.info)
  • Cisapride is a promotility agent, or a medication that is used to encourage normal emptying and forward motion of digestive contents out of the stomach and through the gastrointestinal tract. (allaboutcats.com)
  • Cisapride is only available as a compounded medication, allowing for many different dosage sizes or liquid concentrations based on a prescribing veterinarian's instructions. (allaboutcats.com)
  • Cisapride is not a commercially available medication . (allaboutcats.com)
Medications2
  • Lastly, cisapride can have drug interactions with several other types of medications. (allaboutcats.com)
  • Always make sure to discuss any medications your cat is currently on with your vet before starting cisapride. (allaboutcats.com)
Infants4
  • A total of 35 infants with a postconceptional age of 28 to 54 weeks at the time of the study received a single oral cisapride dose (0.2 mg/kg) at a postnatal age of 4 to 102 days, followed by repeated (n = 7) blood sampling over a 24-hour period. (nih.gov)
  • The apparent renal clearance (CL(R)) of cisapride in infants (n = 28) was estimated to be 0.003 +/- 0.003 L. h(-1). (nih.gov)
  • All infants tolerated a single dose of cisapride well without significant alteration in QTc. (nih.gov)
  • QTc interval in infants receiving cisapride. (bvsalud.org)
Nighttime heartburn1
  • Cisapride is used to treat symptoms of nighttime heartburn in people who have not responded to other treatments. (medlineplus.gov)
Doctor or pharmacist1
  • Talk to your doctor or pharmacist about whether you should be taking cisapride. (medlineplus.gov)
Allergic2
  • tell your doctor and pharmacist if you are allergic to cisapride or any other drugs. (medlineplus.gov)
  • Cisapride is not used by the people who are allergic to it, or if you have bleeding or an obstruction in your stomach, heart disease or hardening of the arteries, a heart rhythm disorder. (medsol.info)
Precautions1
  • What is Cisapride medicine uses, side effects & precautions? (medsol.info)
Pregnant2
  • If you become pregnant while taking cisapride, call your doctor. (medlineplus.gov)
  • Cisapride should be used very cautiously in pregnant or nursing queens. (allaboutcats.com)
Drug1
  • To describe the postmarketing safety data used in the risk assessment of cisapride and to summarize the regulatory actions of the Food and Drug Administration (FDA). (nih.gov)
Constipation2
  • By stimulating smooth muscle in the colon wall, cisapride helps the colon to move feces out and keeps it from backing up and leading to further constipation or obstipation. (allaboutcats.com)
  • Cisapride should also be used cautiously in pets that suffer from constipation, have liver disease, or any signs of bleeding from the digestive tract. (allaboutcats.com)
Treatments1
  • For treatment of this symptom, cisapride is used for those who have not responded to other treatments. (medsol.info)
Tablets1
  • Cisapride is available in both forms tablets or liquid to take by mouth. (medsol.info)
Liquid to take by mouth1
Side2
  • Cisapride may cause side effects. (medlineplus.gov)
  • In this article, you'll learn more about how cisapride works, how it is prescribed, potential side effects, and some frequently asked questions. (allaboutcats.com)
Association1
  • 001, r(2) = 0.47) but not with CL/F. For norcisapride, the mean apparent C(max) was highest and the t(max) was shortest in the oldest postconceptional age group, although no association between postconceptional age and the norcisapride/cisapride area under the curve ratio was observed. (nih.gov)
Helps1
  • Cisapride helps in increasing the digestion rate at which your esophagus, stomach, and intestines move. (medsol.info)
Heart1
  • All the same, any cats with pre-existing heart disease may benefit from regular screening of their heart rate and rhythm while on cisapride. (allaboutcats.com)
Tests1
  • Your doctor will order certain lab tests to check your body's response to cisapride. (medlineplus.gov)
Total1
  • for a total of 341 individual patients affected, following use of cisapride. (nih.gov)