Peptidylprolyl Isomerase
Tacrolimus Binding Proteins
Amino Acid Isomerases
Isomerases
Carbon-Carbon Double Bond Isomerases
Cyclophilins
Immunophilins
Members of a family of highly conserved proteins which are all cis-trans peptidyl-prolyl isomerases (PEPTIDYLPROLYL ISOMERASE). They bind the immunosuppressant drugs CYCLOSPORINE; TACROLIMUS and SIROLIMUS. They possess rotamase activity, which is inhibited by the immunosuppressant drugs that bind to them.
Cyclophilin A
Isomerism
Carbohydrate Epimerases
Proline
Protein Disulfide-Isomerases
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Steroid Isomerases
Amino Acid Sequence
Trans Fatty Acids
UNSATURATED FATTY ACIDS that contain at least one double bond in the trans configuration, which results in a greater bond angle than the cis configuration. This results in a more extended fatty acid chain similar to SATURATED FATTY ACIDS, with closer packing and reduced fluidity. HYDROGENATION of unsaturated fatty acids increases the trans content.
Stereoisomerism
Betula
Databases, Protein
Internet
Metabolomics
Canada
Alberta
A province of western Canada, lying between the provinces of British Columbia and Saskatchewan. Its capital is Edmonton. It was named in honor of Princess Louise Caroline Alberta, the fourth daughter of Queen Victoria. (From Webster's New Geographical Dictionary, 1988, p26 & Room, Brewer's Dictionary of Names, 1992, p12)
Dioxygenases
Carotenoids
Norisoprenoids
beta Carotene
A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
Cyclosporins
A group of closely related cyclic undecapeptides from the fungi Trichoderma polysporum and Cylindocarpon lucidum. They have some antineoplastic and antifungal action and significant immunosuppressive effects. Cyclosporins have been proposed as adjuvants in tissue and organ transplantation to suppress graft rejection.
Hydrogen-Ion Concentration
Proton Pumps
Preferential release of 11-cis-retinol from retinal pigment epithelial cells in the presence of cellular retinaldehyde-binding protein. (1/278)
In photoreceptor cells of the retina, photoisomerization of 11-cis-retinal to all-trans-retinal triggers phototransduction. Regeneration of 11-cis-retinal proceeds via a complex set of reactions in photoreceptors and in adjacent retinal pigment epithelial cells where all-trans-retinol is isomerized to 11-cis-retinol. Our results show that isomerization in vitro only occurs in the presence of apo-cellular retinaldehyde-binding protein. This retinoid-binding protein may drive the reaction by mass action, overcoming the thermodynamically unfavorable isomerization. Furthermore, this 11-cis-retinol/11-cis-retinal-specific binding protein potently stimulates hydrolysis of endogenous 11-cis-retinyl esters but has no effect on hydrolysis of all-trans-retinyl esters. Apo-cellular retinaldehyde-binding protein probably exerts its effect by trapping the 11-cis-retinol product. When retinoid-depleted retinal pigment epithelial microsomes were preincubated with different amounts of all-trans-retinol to form all-trans-retinyl esters and then [3H]all-trans-retinol was added, as predicted, the specific radioactivity of [3H]all-trans-retinyl esters increased during subsequent reaction. However, the specific radioactivity of newly formed 11-cis-retinol stayed constant during the course of the reaction, and it was largely unaffected by expansion of the all-trans-retinyl ester pool during the preincubation. The absence of dilution establishes that most of the ester pool does not participate in isomerization, which in turn suggests that a retinoid intermediate other than all-trans-retinyl ester is on the isomerization reaction pathway. (+info)Identification of a novel nutrient-deprivation-induced Sinorhizobium meliloti gene (hmgA) involved in the degradation of tyrosine. (2/278)
Sinorhizobium meliloti strain N4 carries a Tn5luxAB insertion in a gene which is induced by nitrogen and carbon deprivation as well as in the presence of tyrosine. The Tn5luxAB-tagged locus was found to share significant similarity with the human hmgA gene and the corresponding Aspergillus nidulans gene, encoding the enzyme homogentisate dioxygenase, which is involved in the degradation of tyrosine. Extended DNA sequence analysis of the tagged locus revealed the presence of several ORFs, including one encoding a polypeptide sharing a high degree of similarity with human and fungal maleylacetoacetate isomerases. Strain N4 was found to be unable to use tyrosine as carbon source, to lack homogentisate dioxygenase activity, to produce a melanin-like pigment and to be affected in stationary-phase survival. This is believed to be the first report of a hmgA-homologous gene in bacteria. (+info)Isolation and characterization of the cis-trans-unsaturated fatty acid isomerase of Pseudomonas oleovorans GPo12. (3/278)
Pseudomonas oleovorans contains an isomerase which catalyzes the cis-trans conversion of the abundant unsaturated membrane fatty acids 9-cis-hexadecenoic acid (palmitoleic acid) and 11-cis-octadecenoic acid (vaccenic acid). We purified the isomerase from the periplasmic fraction of Pseudomonas oleovorans. The molecular mass of the enzyme was estimated to be 80 kDa under denaturing conditions and 70 kDa under native conditions, suggesting a monomeric structure of the active enzyme. N-terminal sequencing showed that the isomerase derives from a precursor with a signal sequence which is cleaved from the primary translation product in accord with the periplasmic localization of the enzyme. The purified isomerase acted only on free unsaturated fatty acids and not on esterified fatty acids. In contrast to the in vivo cis-trans conversion of lipids, this in vitro isomerization of free fatty acids did not require the addition of organic solvents. Pure phospholipids, even in the presence of organic solvents, could not serve as substrate for the isomerase. However, when crude membranes from Pseudomonas or Escherichia coli cells were used as phospholipid sources, a cis-trans isomerization was detectable which occurred only in the presence of organic solvents. These results indicate that isolated membranes from Pseudomonas or E. coli cells must contain factors which, activated by the addition of organic solvents, enable and control the cis-trans conversion of unsaturated acyl chains of membrane phospholipids by the periplasmic isomerase. (+info)cis/trans isomerase of unsaturated fatty acids of Pseudomonas putida P8: evidence for a heme protein of the cytochrome c type. (4/278)
From a pool of 600 temperature-sensitive transposon mutants of Pseudomonas putida P8, 1 strain was isolated that carries a mini-Tn5 insertion within the cytochrome c operon. As a result, genes involved in the attachment of heme to cytochrome c-type proteins are turned off. Accordingly, cytochrome c could not be detected spectrophotometrically. The mutant also exhibited a remarkable reduction of cis-trans isomerization capability for unsaturated fatty acids. Consistent with the genetic and physiological data is the detection of a cytochrome c-type heme-binding motif close to the N terminus of the predicted polypeptide of the cis/trans isomerase (cti) gene (CVACH; conserved amino acids in italics). The functional significance of this motif was proven by site-directed mutagenesis. A possible mechanism of heme-catalyzed cis-trans isomerization of unsaturated fatty acids is discussed. (+info)Identification of RPE65 in transformed kidney cells. (5/278)
The protein RPE65 has an important role in retinoid processing and/or retinoid transport in the eye. Retinoids are involved in cell differentiation, embryogenesis and carcinogenesis. Since the kidney is known as an important site for retinoid metabolism, the expression of RPE65 in normal kidney and transformed kidney cells has been examined. The RPE65 mRNA was detected in transformed kidney cell lines including the human embryonic kidney cell line HEK293 and the African green monkey kidney cell lines COS-1 and COS-7 by reverse transcription PCR. In contrast, it was not detected in human primary kidney cells or monkey kidney tissues under the same PCR conditions. The RPE65 protein was also identified in COS-7 and HEK293 cells by Western blot analysis using a monoclonal antibody to RPE65, but not in the primary kidney cells or kidney tissues. The RPE65 cDNA containing the full-length encoding region was amplified from HEK293 and COS-7 cells. DNA sequencing showed that the RPE65 cDNA from HEK293 cells is identical to the RPE65 cDNA from the human retinal pigment epithelium. The RPE65 from COS-7 cells shares 98 and 99% sequence identity with human RPE65 at the nucleotide and amino acid levels, respectively. Moreover, the RPE65 mRNA was detected in three out of four renal tumor cultures analyzed including congenital mesoblastic nephroma and clear cell sarcoma of the kidney. These results demonstrated that transformed kidney cells express this retinoid processing protein, suggesting that these transformed cells may have an alternative retinoid metabolism not present in normal kidney cells. (+info)Involvement of the cis/trans isomerase Cti in solvent resistance of Pseudomonas putida DOT-T1E. (6/278)
Pseudomonas putida DOT-T1E is a solvent-resistant strain that is able to grow in the presence of high concentrations of toluene. We have cloned and sequenced the cti gene of this strain, which encodes the cis/trans isomerase, termed Cti, that catalyzes the cis-trans isomerization of esterified fatty acids in phospholipids, mainly cis-oleic acid (C(16:1,9)) and cis-vaccenic acid (C(18:1,11)), in response to solvents. To determine the importance of this cis/trans isomerase for solvent resistance a Cti-null mutant was generated and characterized. This mutant showed a longer lag phase when grown with toluene in the vapor phase; however, after the lag phase the growth rate of the mutant strain was similar to that of the wild type. The mutant also showed a significantly lower survival rate when shocked with 0.08% (vol/vol) toluene. In contrast to the wild-type strain, which grew in liquid culture medium at temperatures up to 38.5 degrees C, the Cti-null mutant strain grew significantly slower at temperatures above 37 degrees C. An in-frame fusion of the Cti protein with the periplasmic alkaline phosphatase suggests that this constitutively expressed enzyme is located in the periplasm. Primer extension studies confirmed the constitutive expression of Cti. Southern blot analysis of total DNA from various pseudomonads showed that the cti gene is present in all the tested P. putida strains, including non-solvent-resistant ones, and in some other Pseudomonas species. (+info)Molecular analysis of maleate cis-trans isomerase from thermophilic bacteria. (7/278)
Several strains of thermophilic bacteria containing maleate cis-trans isomerase were isolated from soil samples and identified as Bacillus stearothermophilus, Bacillus circulans, Bacillus brevis, and Deleya halophila. The maleate cis-trans isomerase was purified and characterized from one of the isolated strains, B. stearothermophilus MI-102. The purified enzyme of strain MI-102 showed higher thermal stability than the enzyme of a mesophile, Alcaligenes faecalis IFO13111. The seven maleate cis-trans isomerase genes (maiA) of thermophile were cloned and sequenced. B. stearothemophilus MI-102 MaiA has 67% amino acid identity with A. faecalis MaiA. All eight amino acid sequences of maiA gene products had significant conserved regions containing cysteine residues, which were previously suggested to be involved in an active site of the enzyme. To probe the catalytic mechanism, three cysteine residues in the conserved regions of A. faecalis MaiA were replaced with serine by site-directed mutagenesis. The results suggest that Cys80 and Cys198 play important roles in the enzyme activity. (+info)Rapid restoration of visual pigment and function with oral retinoid in a mouse model of childhood blindness. (8/278)
Mutations in the retinal pigment epithelium gene encoding RPE65 are a cause of the incurable early-onset recessive human retinal degenerations known as Leber congenital amaurosis. Rpe65-deficient mice, a model of Leber congenital amaurosis, have no rod photopigment and severely impaired rod physiology. We analyzed retinoid flow in this model and then intervened by using oral 9-cis-retinal, attempting to bypass the biochemical block caused by the genetic abnormality. Within 48 h, there was formation of rod photopigment and dramatic improvement in rod physiology, thus demonstrating that mechanism-based pharmacological intervention has the potential to restore vision in otherwise incurable genetic retinal degenerations. (+info)
RPE65 Antibody | scrazzl.com - Simply Connecting Science
RPE65 Antibody | scrazzl.com - Simply Connecting Science
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SCOPe 2.07: Protein: Mitochondrial peptidyl-prolyl cis-trans isomerase, cyclophilin F
Mitochondrial peptidyl-prolyl cis-trans isomerase, cyclophilin F ... for Protein Mitochondrial peptidyl-prolyl cis-trans isomerase, ... Protein Mitochondrial peptidyl-prolyl cis-trans isomerase, cyclophilin F from b.62.1.1: Cyclophilin (peptidylprolyl isomerase) ... Protein Mitochondrial peptidyl-prolyl cis-trans isomerase, cyclophilin F from b.62.1.1: Cyclophilin (peptidylprolyl isomerase) ... Lineage for Protein: Mitochondrial peptidyl-prolyl cis-trans isomerase, cyclophilin F. *Root: SCOPe 2.07 *. Class b: All beta ...
Chain A, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (human) | Protein Target - PubChem
SCOPe 2.07: Protein: Peptidyl-prolyl cis-trans isomerase-like 2, Cyclophilin-60, PPI domain
Peptidyl-prolyl cis-trans isomerase-like 2, Cyclophilin-60, PPI domain ... peptidylprolyl isomerase). Timeline for Protein Peptidyl-prolyl cis-trans isomerase-like 2, Cyclophilin-60, PPI domain from b. ... peptidylprolyl isomerase) first appeared in SCOP 1.73. *Protein Peptidyl-prolyl cis-trans isomerase-like 2, Cyclophilin-60, PPI ... 62.1.1: Cyclophilin (peptidylprolyl isomerase): *Protein Peptidyl-prolyl cis-trans isomerase-like 2, Cyclophilin-60, PPI domain ...
SCOPe 2.07: Protein: Peptidyl-prolyl cis-trans isomerase-like 1, PPIL1
Timeline for Protein Peptidyl-prolyl cis-trans isomerase-like 1, PPIL1 from b.62.1.1: Cyclophilin (peptidylprolyl isomerase): * ... Protein Peptidyl-prolyl cis-trans isomerase-like 1, PPIL1 from b.62.1.1: Cyclophilin (peptidylprolyl isomerase) first appeared ... Protein Peptidyl-prolyl cis-trans isomerase-like 1, PPIL1 from b.62.1.1: Cyclophilin (peptidylprolyl isomerase) appears in ... More info for Protein Peptidyl-prolyl cis-trans isomerase-like 1, PPIL1 from b.62.1.1: Cyclophilin (peptidylprolyl isomerase). ...
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KEGG ENZYME: 5.2.1.11
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Peptidyl-Prolyl cis-trans Isomerase (PPIase) assays. 22 02 17. Having worked wit Selcia on a number of projects I always keep ... Selcia have now expanded the range of Peptidyl-Prolyl cis-trans Isomerase (PPIase) assays they can offer. ... an eye out for news on their work on Peptidyl-Prolyl cis-trans Isomerases (PPIase). These are very interesting class of enzymes ... whose principal function is to catalyse the cis-trans isomerisation of the X-Pro peptide bonds in polypeptide chains (where X ...
Pin1 Inhibitor, DTM - Calbiochem | 530618
Shown to specifically inhibit peptidyl-prolyl cis/trans isomerase activity in HeLa cells. Inhibits the proliferation of HCT116 ... Shown to specifically inhibit peptidyl-prolyl cis/trans isomerase activity in HeLa cells. Inhibits the proliferation of HCT116 ... Peptidylpropyl cis-trans Isomerase Inhibitors ... Peptidylpropyl cis-trans Isomerase Inhibitors>. *Pin1 Inhibitor ...
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FK506-binding proteins (FKBPs) contain a domain with peptidyl-prolyl-cis/trans-isomerase (PPIase) activity and bind the ... The intriguing cyclophilin A-HIV-1 Vpr interaction: prolyl cis/trans isomerisation catalysis and specific binding. ... The interaction of HIV-1 viral protein R (Vpr) with the human peptidyl prolyl isomerase CypA is known to occur in vitro and in ...
Enhanced bioavailability of lycopene when consumed as cis-isomers from tangerine compared to red tomato juice, a randomized,...
Our bodies most use the "cis" form of lycopene, which is a very small amount of red tomato lycopene. Most is the "trans" form. ... These tomatoes have the recessive mutation tangerine and lack a functional form of the enzyme carotenoid isomerase (CRTISO), ... Heating tomatoes for a limited period of time, like we do with sauce, helps convert a bit of the "trans" to "cis." Heat needs ... Tetra-cis-lycopene absorbs light maximally approximately 35 nm below all-trans-lycopene, resulting in tomatoes with an orange ...
WW domains function and as models for folding studies | Macias Group
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A Covalent Succinylcysteine-like Intermediate in the Enzyme-Catalyzed Transformation of Maleate to Fumarate by Maleate Isomerase
Covalent Succinylcysteine-like Intermediate in the Enzyme-Catalyzed Transformation of Maleate to Fumarate by Maleate Isomerase ... Maleate isomerase (MI), a member of the Asp/Glu racemase superfamily, catalyzes cis−trans isomerization of the C2−C3 double ... isomerization reactioncovalentMutational studiessuperfamilyFumaratecatalyzecysteinemodeMaleate IsomeraseMaleate isomerase ... Covalent Succinylcysteine-like Intermediate in the Enzyme-Catalyzed Transformation of Maleate to Fumarate by Maleate Isomerase ...
Neuroanatomical quantitative proteomics reveals common pathogenic biological routes between amyotrophic lateral sclerosis (ALS)...
Saturated Fat. On your Plate or in your Blood? | Richard David Feinman
Was the palmitoleic acid they found cis or trans? Theres trans in dairy foods. ... Apparently at least some bacteria have isomerases, which they use when stressed. One theory is that stress like high heat ... Trans-9- and trans-3-18:1 are occasionally reported from seed oils. Otherwise, trans-18:1 isomers are only rarely encountered ... The trans fats in dairy foods are beneficial, however, as far as anyone can tell. If the trans fat is made in a body and not in ...
E-libraryme: Photochromic Materials
Glucose-6-phosphate 1-epimerase. In enzymology, a glucose-6-phosphate 1-epimerase is an enzyme that catalyzes the chemical...
This enzyme belongs to the family of isomerases, specifically those racemases and epimerases acting on carbohydrates and ... pyruvate dehydrogenase (acetyl-trans ... (R)-2-hydroxyacid dehydrogenase. (R)-6-hydroxynicotine oxidase ... 3-carboxy-cis,cis-muconate cycloisomerase. Film. Television show. Game. Sport. Science. ...
MMTB
2E,6E)-farnesyl_diphosphate + n isopentenyl_diphosphate <=> n diphosphate + di-trans,poly-cis-polyprenyl_diphosphate 2.5.1.87 ... 5.3.3.2 isopentenyl-diphosphate Delta-isomerase - BRENDA: BR247 KEGG: R01123 MetaCyc: IPPISOM-RXN ... 2Z,6E)-farnesyl_diphosphate + n isopentenyl_diphosphate <=> n diphosphate + trans,poly-cis-polyprenyl_diphosphate 2.5.1.88 ... n isopentenyl_diphosphate <=> cis-1,4-polyisoprene + n diphosphate 2.5.1.20 rubber cis-polyprenylcistransferase - ...
Prolyl isomeraseCyclophilinPPIasePIN1PPIasesPeptidylprolyl cis-trans isomPrecursorProtein disulfideIsomerization of prolineSynthesized byFK506EncodesArabidopsisEnzymesPeptideAntibodyCatalyzes the isomerizationFatty acidsProteinsPeriplasmicSapiensSubstratesInhibitorCatalyzeToluenePeptidesPPIL2ActivityInactiveChaperonePhospholipidsSubstrateMolecularAbsorptionColiMembranes
Prolyl isomerase11
- Together, these results demonstrate that PpiB contributes to S. aureus virulence via a mechanism unrelated to prolyl isomerase activity. (asm.org)
- This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. (nih.gov)
- Pin1 is a unique peptidyl-prolyl isomerase that catalyzes cis-trans isomerization of phosphorylated Ser/Thr-Pro motifs. (hindawi.com)
- The FKBP14 gene provides instructions for making a protein called FKBP prolyl isomerase 14 (also known as FKBP22). (medlineplus.gov)
- FKBP prolyl isomerase 14 is thought to assist with protein folding, particularly the folding of procollagens. (medlineplus.gov)
- Studies suggest that FKBP prolyl isomerase 14 may also play a role in processing other components of the extracellular matrix. (medlineplus.gov)
- The extra or missing genetic material prevents the gene from making functional FKBP prolyl isomerase 14. (medlineplus.gov)
- This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. (novusbio.com)
- Overexpression of the prolyl isomerase PIN1 promotes cell growth in osteosarcoma cells. (biomedsearch.com)
- Objective- The Pin1 prolyl isomerase acts in concert with proline-directed protein kinases to regulate function of protein substrates through isomerization of peptide bonds that link phosphoserine or phosphothreonine to proline. (ahajournals.org)
- This mechanism involves phosphorylation-dependent conformational changes that are induced by the Pin1 prolyl isomerase. (ahajournals.org)
Cyclophilin3
- The Staphylococcus aureus cyclophilin PpiB is an intracellular peptidyl prolyl cis/trans isomerase (PPIase) that has previously been shown to contribute to secreted nuclease and hemolytic activity. (asm.org)
- This gene is a member of the cyclophilin family of peptidylprolyl isomerases. (mybiosource.com)
- Another of the lumenal proteins was suggested to be a lumenal cyclophilin-type peptidyl prolyl cis-trans isomerase by the effect of cyclosporin A. We propose that molecular chaperones, such as protein disulphide isomerase and cyclophilin may represent two of the lumenal proteins which are involved in completion of translocation. (kent.ac.uk)
PPIase11
- Human Pin 1 is a peptidyl-prolyl cis/trans isomerase (PPIase) that interacts with NIMA and essential for cell cycle regulation Pin1 is nuclear PPIase containing a WW protein interaction domain, and is structurally and functionally related to Ess1/Ptf1, an essential protein in budding yeast. (creative-enzymes.com)
- Previous work in our lab investigating the process of Nuc secretion identified an intracellular peptidyl-prolyl cis/trans isomerase (PPIase), PpiB, that contributes to Nuc activity ( 8 ). (asm.org)
- PPIase enzymes (also known as foldases) catalyze the cis -to- trans isomerization of proline peptide bonds, which is often the rate-limiting step in protein folding ( 9 ). (asm.org)
- Also known as Inactive peptidyl-prolyl cis-trans isomerase FKBP6 (Inactive PPIase FKBP6) (36 kDa FK506-binding protein) (36 kDa FKBP) (FKBP-36) (FK506-binding protein 6) (FKBP-6) (Immunophilin FKBP36). (mybiosource.com)
- The effect of peptidyl-prolyl cis-trans isomerase (PPIase) on the refolding and reactivation courses of urea-denatured creatine kinase was followed by fluorescence emission, ultraviolet difference spectra and recovery of activity. (elsevier.com)
- Binding to membrane-coupled peptides occurred through the central peptidyl-prolyl- cis / trans isomerase (PPIase) domain of TF, however, independently of prolyl residues. (pnas.org)
- TF has a modular structure with an N-terminal domain that mediates ribosome binding, a central peptidyl-prolyl- cis / trans isomerase (PPIase) domain with homology to FK506-binding proteins (FKBPs), and a C-terminal domain with unknown function ( 6 , 9 , 10 ). (pnas.org)
- The peptidyl-prolyl cis/trans isomerase (PPIase) class of proteins comprises three member families that are found throughout nature and are present in all the major compartments of the cell. (mendeley.com)
- An enzyme which catalyses this slow rotation was found and called peptidyl prolyl cis-trans isomerase (PPIase) (1). (bioscience.org)
- PIN1 was recently identified as a peptidyl-prolyl cis-trans isomerase (PPIase). (biomedsearch.com)
- The Peptidyl-Prolyl cis-trans Isomerase (PPIase) family is the most abundant protein family in the thylakoid lumen. (diva-portal.org)
PIN12
- A homologue of the human site-specific prolyl cis/trans isomerase PIN1 was identified in Arabidopsis thaliana. (ugent.be)
- 3 Pin1 catalyzes the cis to trans isomerization of peptide bonds that link phosphoserine or phosphothreonine to proline. (ahajournals.org)
PPIases2
- Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. (antikoerper-online.de)
- Peptidyl prolyl cis/trans isomerases (PPIases) are a superfamily of proteins ubiquitously distributed among living organisms, which function primarily to assist the folding and structuring of unfolded and partially folded polypeptide chains and proteins. (soton.ac.uk)
Peptidylprolyl cis-trans isom1
- One of the rate-limiting steps in protein folding has been shown to be the cis-trans isomerization of proline residues, which is catalyzed by a range of peptidylprolyl cis-trans isomerases. (kent.ac.uk)
Precursor2
- Peptidyl-prolyl cis-trans isomerase F, mitochondrial precursor or PPIF is protein involved in reactive oxygen species stress response (ROS stress response). (me-pedia.org)
- N-terminal sequencing showed that the isomerase derives from a precursor with a signal sequence which is cleaved from the primary translation product in accord with the periplasmic localization of the enzyme. (wikigenes.org)
Protein disulfide4
- Hence we propose that, similar to protein disulfide isomerase and other folding catalysts, SurA exhibits a modular architecture composed of a substrate binding domain and distinct catalytically active domains. (kent.ac.uk)
- 蛋白质二硫化物异构酶(Protein disulfide isomerase,PDI) 30. (coursera.org)
- Modular organisation of the domains in protein disulfide isomerase‐related proteins. (els.net)
- Ali Khan H and Mutus B (2014) Protein disulfide isomerase a multifunctional protein with multiple physiological roles. (els.net)
Isomerization of proline3
- It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. (uniprot.org)
- Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins (PubMed:8977107, PubMed:18258190, PubMed:20677832, PubMed:20541251). (rcsb.org)
- May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins (By similarity). (genecards.org)
Synthesized by1
- The isomerase in this pathway uses all- trans -retinyl esters (a t RE's) synthesized by lecithin:retinol acyl transferase (LRAT) as substrate. (arvojournals.org)
FK5061
- In the plant Arabidopsis thaliana, we found that intracellular acid stress generated by weak organic acids at normal external pH induces expression of several chaperone genes, including ROF2, which encodes a peptidyl-prolyl cis-trans isomerase of the FK506-binding protein class. (upv.es)
Encodes1
- We have cloned and sequenced the cti gene of this strain, which encodes the cis/trans isomerase, termed Cti, that catalyzes the cis-trans isomerization of esterified fatty acids in phospholipids, mainly cis -oleic acid (C 16:1,9 ) and cis -vaccenic acid (C 18:1,11 ), in response to solvents. (asm.org)
Arabidopsis1
- The first three enzymatic steps of the strigolactone biosynthetic pathway catalysed by β-carotene cis-trans isomerase Dwarf27 (D27) from Oryza sativa and carotenoid cleavage dioxygenases CCD7 and CCD8 from Arabidopsis thaliana have been reconstituted in vitro, and kinetic assays have been developed for each enzyme, in order to develop selective enzyme inhibitors. (nih.gov)
Enzymes3
- By developing a functional screen, we classify the family of Mtb Ech proteins as monofunctional or bifunctional enzymes, three of which complement the FadAB complex to degrade cis fatty acids. (elsevier.com)
- Crystal structure determination of two cis-trans enoyl coenzyme A (CoA) isomerases reveals distinct placement of active-site residue in Ech enzymes. (elsevier.com)
- Our studies thus reveal versatility of Mtb lipid-remodeling enzymes and identify an essential role of stand-alone cis-trans enoyl CoA isomerases in mycobacterial biology. (elsevier.com)
Peptide2
- a) The steric hindrance around the amide bond favours the trans‐conformation of a peptide bond. (els.net)
- Cis-trans isomerization of peptide bonds preceding the amino acid proline is the rate-limiting step of protein folding and several immunophilins have been shown to be important for catalysis of protein folding in vivo. (diva-portal.org)
Antibody1
- The peptidyl-prolyl cis/trans isomerase (Trigger Factor) antibody can be used for reducing or non-reducing Western blots and immunoprecipitation studies. (clontech.com)
Catalyzes the isomerization2
- In biochemistry, cis-trans isomerase is a type of isomerase which catalyzes the isomerization of geometric isomers. (wikipedia.org)
- Z-ISO then catalyzes the isomerization of the central double bond to form 9,9′-di- cis -ζ-carotene. (nih.gov)
Fatty acids7
- There are two major mechanisms involving esterified fatty acids: a shift in the unsaturated/saturated fatty acid ratio, and cis-trans isomerization. (asm.org)
- cis fatty acids are present in most bacteria, whereas the trans isomers are less widespread. (asm.org)
- Further details about trans fatty acids in bacteria are given in the review by Keweloh and Heipieper ( 21 ). (asm.org)
- The cis-trans isomerization triggered by solvent exposure, which occurs without shifts in the position of the double bond of the C 16:1,9 and C 18:1,11 fatty acids, was shown to be a postsynthetic enzyme modification in Pseudomonas putida P8 ( 8 ). (asm.org)
- Toluene causes an increase in membrane fluidity which is counteracted by an elevated level of trans fatty acids and an increase in the content of cardiolipin as the phospholipid headgroup ( 33 ). (asm.org)
- We studied the pattern of the cis - trans isomerization of unsaturated fatty acids in cells of Pseudomonas putida S12 grown in a medium supplemented with oleic acid which was deuterated at both of the C atoms of its double bond. (ufz.de)
- The purified isomerase acted only on free unsaturated fatty acids and not on esterified fatty acids. (wikigenes.org)
Proteins1
- One of the lumenal proteins was identified as protein disulphide isomerase by immunoprecipitation. (kent.ac.uk)
Periplasmic2
- Interaction of the periplasmic peptidylprolyl cis-trans isomerase SurA with model peptides. (kent.ac.uk)
- To characterize the interaction between model peptides and the periplasmic peptidylprolyl cis-trans isomerase SurA from E. coli, we employed a chemical cross-linking strategy that has been used previously to elucidate the interaction of substrates with other folding catalysts. (kent.ac.uk)
Sapiens1
- Identification and comparative analysis of the peptidyl-prolyl cis/trans isomerase repertoires of H. sapiens, D. melanogaster, C. elegans, S. cerevisiae and Sz. (mendeley.com)
Substrates3
- The regional specificity and the kinetics of the isomerization reaction were investigated in vitro using purified enzyme and biphasic liposome-based systems carrying specific cis-configured lycopene species as substrates. (nih.gov)
- We incubated chicken retina and bovine RPE membranes with all- trans -retinol (a t ROL) or 11- cis -retinol (11 c ROL) substrates and analyzed for production of new retinoids by HPLC. (arvojournals.org)
- Here, we show that the Mtb fatty acid degradation (FadAB) complex cannot selectively break down cis fatty acyl substrates. (elsevier.com)
Inhibitor1
- Gene Ontology (GO) annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity and calcium channel inhibitor activity . (genecards.org)
Catalyze1
- Concurrently, protein-disulfide isomerases (PDIs), and peptidyl-prolyl cis-trans -isomerases (PPIs) catalyze rate-limiting steps of protein folding ( 4 , 5 ). (mcponline.org)
Toluene2
- We studied the influence of cis-trans isomerization on toluene resistance in Pseudomonas putida DOT-T1E ( 31-33 ), a strain which can grow in the presence of 90% (vol/vol) toluene and use toluene as the sole source of carbon and energy. (asm.org)
- The cis/trans ratio decreases from 7.5 to 1 when cells are grown in the presence of 1% (vol/vol) toluene in Luria-Bertani (LB) medium. (asm.org)
Peptides1
- From results obtained by limited proteolysis we conclude that an N-terminal fragment of SurA, comprising 150 amino acids that do not contain the active sites involved in the peptidylprolyl cis-trans isomerization, is essential for the binding of peptides by SurA. (kent.ac.uk)
PPIL21
- PPIL2 (Peptidylprolyl Isomerase Like 2) is a Protein Coding gene. (genecards.org)
Activity4
- 1) Cone-dominant chicken retinas contain a retinoid isomerase activity distinct from the isomerase in RPE. (arvojournals.org)
- this requires proline isomerase activity (PubMed:20677832, PubMed:20541251, PubMed:20460131). (rcsb.org)
- Predicted to have cyclosporin A binding activity and peptidyl-prolyl cis-trans isomerase activity. (mcw.edu)
- The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. (abcam.com)
Inactive1
- Below are the list of possible Inactive peptidyl-prolyl cis-trans isomerase products. (mybiosource.com)
Chaperone2
- Also known as peptidyl-prolyl cis/trans isomerase, the 48 kDa Trigger Factor (TF) is a chaperone protein found in eubacteria. (clontech.com)
- We identify new functional chaperone modules, including interactions between protein-disulfide isomerases and peptidyl-prolyl cis-trans -isomerases. (mcponline.org)
Phospholipids1
- Pure phospholipids, even in the presence of organic solvents, could not serve as substrate for the isomerase. (wikigenes.org)
Substrate2
- CRTISO, an evolutionary descendant of the bacterial carotene desaturase CRTI, catalyzes the cis-to-trans isomerization reactions leading to all-trans-lycopene, the substrate for the subsequent lycopene cyclization to form all-trans-α/β-carotene. (nih.gov)
- In vitro assay of CRTISO isomerization reaction with 7,9,9′,7′-tetra- cis -lycopene (prolycopene) as a substrate. (nih.gov)
Molecular1
- Yang, HP , Zhong, H & Zhou, HM 1997, ' Catalysis of the refolding of urea denatured creatine kinase by peptidyl-prolyl cis-trans isomerase ', Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology , vol. 1338, no. 2, pp. 147-150. (elsevier.com)
Absorption1
- Regeneration of 11- cis -retinaldehyde (11 c RAL) chromophore following light absorption involves an enzyme pathway called the visual cycle in the RPE. (arvojournals.org)
Coli1
- a) Domain organisation and three‐dimensional structure of E. coli Trigger factor (TF, PDB ID: 1W26): the N‐terminal domain (N, green) contains the ribosome‐binding region and is connected by a long loop to the peptidyl‐prolyl cis-trans isomerase domain (PPI, purple), the C‐terminal domain (C, red) contains the binding site for the nascent polypeptide chain and occupies the central part of the protein. (els.net)
Membranes2
- In contrast, chicken retina membranes synthesized significantly more 11- cis -retinyl esters (11 c RE's). (arvojournals.org)
- 3) The formation of 11- cis -retinoids from a t ROL by chicken retina membranes is driven by mass action through secondary esterification of the 11 c ROL product. (arvojournals.org)