A genus of the family CIRCOVIRIDAE that infects SWINE; PSITTACINES; and non-psittacine BIRDS. Species include Beak and feather disease virus causing a fatal disease in psittacine birds, and Porcine circovirus causing postweaning multisystemic wasting syndrome in pigs (PORCINE POSTWEANING MULTISYSTEMIC WASTING SYNDROME).
Virus diseases caused by the CIRCOVIRIDAE.
A condition of involuntary weight loss of greater then 10% of baseline body weight. It is characterized by atrophy of muscles and depletion of lean body mass. Wasting is a sign of MALNUTRITION as a result of inadequate dietary intake, malabsorption, or hypermetabolism.
A worldwide emerging disease of weaned piglets first recognized in swine herds in western Canada in 1997. This syndrome is characterized by progressive weight loss, rapid (tachypnea) and difficult (dyspnea) breathing, and yellowing of skin. PMWS is caused by PORCINE CIRCOVIRUS infection, specifically type 2 or PCV-2.
Diseases of domestic swine and of the wild boar of the genus Sus.
A family of very small viruses containing circular, single-stranded DNA and possessing no envelope. The modes of transmission are not known.
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
A species of PARVOVIRUS causing reproductive failure in pigs.
A species of ARTERIVIRUS causing reproductive and respiratory disease in pigs. The European strain is called Lelystad virus. Airborne transmission is common.
Deoxyribonucleic acid that makes up the genetic material of viruses.
The complete genetic complement contained in a DNA or RNA molecule in a virus.
A syndrome characterized by outbreaks of late term abortions, high numbers of stillbirths and mummified or weak newborn piglets, and respiratory disease in young unweaned and weaned pigs. It is caused by PORCINE RESPIRATORY AND REPRODUCTIVE SYNDROME VIRUS. (Radostits et al., Veterinary Medicine, 8th ed, p1048)
Immunoglobulins produced in response to VIRAL ANTIGENS.
The thin, yellow, serous fluid secreted by the mammary glands during pregnancy and immediately postpartum before lactation begins. It consists of immunologically active substances, white blood cells, water, protein, fat, and carbohydrates.
Proteins that form the CAPSID of VIRUSES.
Suspensions of attenuated or killed viruses administered for the prevention or treatment of infectious viral disease.
Diseases of birds not considered poultry, therefore usually found in zoos, parks, and the wild. The concept is differentiated from POULTRY DISEASES which is for birds raised as a source of meat or eggs for human consumption, and usually found in barnyards, hatcheries, etc.
Permanent deprivation of breast milk and commencement of nourishment with other food. (From Stedman, 25th ed)
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
An order of BIRDS comprised of several families and more than 300 species. It includes COCKATOOS; PARROTS; PARAKEETS; macaws; and BUDGERIGARS.
A species of non-enveloped DNA virus in the genus ANELLOVIRUS, associated with BLOOD TRANSFUSIONS; and HEPATITIS. However, no etiological role has been found for TTV in hepatitis.
The presence of viruses in the blood.
A sequence of successive nucleotide triplets that are read as CODONS specifying AMINO ACIDS and begin with an INITIATOR CODON and end with a stop codon (CODON, TERMINATOR).
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.
Property, such as patents, trademarks, and copyright, that results from creative effort. The Patent and Copyright Clause (Art. 1, Sec. 8, cl. 8) of the United States Constitution provides for promoting the progress of science and useful arts by securing for limited times to authors and inventors, the exclusive right to their respective writings and discoveries. (From Black's Law Dictionary, 5th ed, p1014)
Exclusive legal rights or privileges applied to inventions, plants, etc.
A species of ARENAVIRUS, one of the New World Arenaviruses (ARENAVIRUSES, NEW WORLD), causing a fatal infection in the cricetine rodent Oryzomys albigularis. Asymptomatic laboratory infection in humans has been reported.
A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.
Virus diseases caused by the ARENAVIRIDAE.
Enzymes that catalyze the transfer of aldehyde or ketone residues. EC 2.2.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Vaccines used to prevent infection by viruses in the family ORTHOMYXOVIRIDAE. It includes both killed and attenuated vaccines. The composition of the vaccines is changed each year in response to antigenic shifts and changes in prevalence of influenza virus strains. The vaccine is usually bivalent or trivalent, containing one or two INFLUENZAVIRUS A strains and one INFLUENZAVIRUS B strain.
Suspensions of killed or attenuated microorganisms (bacteria, viruses, fungi, protozoa), antigenic proteins, synthetic constructs, or other bio-molecular derivatives, administered for the prevention, amelioration, or treatment of infectious and other diseases.
An acute viral infection in humans involving the respiratory tract. It is marked by inflammation of the NASAL MUCOSA; the PHARYNX; and conjunctiva, and by headache and severe, often generalized, myalgia.
Revenues or receipts accruing from business enterprise, labor, or invested capital.
A subtype of INFLUENZA A VIRUS with the surface proteins hemagglutinin 1 and neuraminidase 1. The H1N1 subtype was responsible for the Spanish flu pandemic of 1918.
Administration of vaccines to stimulate the host's immune response. This includes any preparation intended for active immunological prophylaxis.
Vaccines in which the infectious microbial nucleic acid components have been destroyed by chemical or physical treatment (e.g., formalin, beta-propiolactone, gamma radiation) without affecting the antigenicity or immunogenicity of the viral coat or bacterial outer membrane proteins.
Carnivores of genus Mustela of the family MUSTELIDAE. The European mink, which has white upper and lower lips, was widely trapped for commercial purposes and is classified as endangered. The American mink, lacking a white upper lip, is farmed commercially.
Inflammation of any segment of the SMALL INTESTINE.
A species of PARVOVIRUS infecting cats with a highly contagious enteric disease. Host range variants include mink enteritis virus, canine parvovirus (PARVOVIRUS, CANINE), and raccoon parvovirus. After infecting their new hosts, many of these viruses have further evolved and are now considered distinct species.
A species of the genus PARVOVIRUS and a host range variant of FELINE PANLEUKOPENIA VIRUS. It causes a highly infectious fulminating ENTERITIS in dogs producing high mortality. It is distinct from CANINE MINUTE VIRUS, a species in the genus BOCAVIRUS. This virus can also infect cats and mink.
Use of written, printed, or graphic materials upon or accompanying a product or its container or wrapper. It includes purpose, effect, description, directions, hazards, warnings, and other relevant information.

Identification of a novel GC-rich 113-nucleotide region to complete the circular, single-stranded DNA genome of TT virus, the first human circovirus. (1/377)

The sequence data (H. Okamoto et al., Hepatol. Res. 10:1-16, 1998) of a newly discovered single-stranded DNA virus, TT virus (TTV), showed that it did not have the terminal structure typical of a parvovirus. Elucidation of the complete genome structure was necessary to understand the nature of TTV. We obtained a 1.0-kb amplified product from serum samples of four TTV carriers by an inverted, nested long PCR targeted for nucleotides (nt) 3025 to 3739 and 1 to 216 of TTV. The sequence of a clone obtained from serum sample TA278 was compared with those registered in GenBank. The complete circular TTV genome contained a novel sequence of 113 nt (nt 3740 to 3852 [=0]) in between the known 3'- and 5'-end arms, forming a 117-nt GC-rich stretch (GC content, 90.6% at nt 3736 to 3852). We found a 36-nt stretch (nt 3816 to 3851) with an 80.6% similarity to chicken anemia virus (CAV) (nt 2237 to 2272 of M55918), a vertebrate circovirus. A putative SP-1 site was located at nt 3834 to 3839, followed by a TATA box at nt 85 to 90, the first initiation codon of a putative VP2 at nt 107 to 109, the termination codon of a putative VP1 at nt 2899 to 2901, and a poly(A) signal at nt 3073 to 3078. The arrangement was similar to that of CAV. Furthermore, several AP-2 and ATF/CREB binding sites and an NF-kappaB site were arranged around the GC-rich region in both TTV and CAV. The data suggested that TTV is circular and similar to CAV in its genomic organization, implying that TTV is the first human circovirus.  (+info)

Evidence that a plant virus switched hosts to infect a vertebrate and then recombined with a vertebrate-infecting virus. (2/377)

There are several similarities between the small, circular, single-stranded-DNA genomes of circoviruses that infect vertebrates and the nanoviruses that infect plants. We analyzed circovirus and nanovirus replication initiator protein (Rep) sequences and confirmed that an N-terminal region in circovirus Reps is similar to an equivalent region in nanovirus Reps. However, we found that the remaining C-terminal region is related to an RNA-binding protein (protein 2C), encoded by picorna-like viruses, and we concluded that the sequence encoding this region of Rep was acquired from one of these single-stranded RNA viruses, probably a calicivirus, by recombination. This is clear evidence that a DNA virus has incorporated a gene from an RNA virus, and the fact that none of these viruses code for a reverse transcriptase suggests that another agent with this capacity was involved. Circoviruses were thought to be a sister-group of nanoviruses, but our phylogenetic analyses, which take account of the recombination, indicate that circoviruses evolved from a nanovirus. A nanovirus DNA was transferred from a plant to a vertebrate. This transferred DNA included the viral origin of replication; the sequence conservation clearly indicates that it maintained the ability to replicate. In view of these properties, we conclude that the transferred DNA was a kind of virus and the transfer was a host-switch. We speculate that this host-switch occurred when a vertebrate was exposed to sap from an infected plant. All characterized caliciviruses infect vertebrates, suggesting that the host-switch happened first and that the recombination took place in a vertebrate.  (+info)

Ultrastructure of porcine circovirus in persistently infected PK-15 cells. (3/377)

The ultrastructure of porcine circovirus was examined in persistently infected porcine kidney (PK)-15 cells. Virus-infected PK-15 cells had large numbers of intracytoplasmic inclusions, and a few cells had intranuclear inclusions. Intracytoplasmic inclusions were dispersed throughout the cytoplasm but were most numerous in the perinuclear cytoplasm. Inclusion were of various sizes, round to oval, and electron dense and were of two general types. Inclusions of the first type were small (0.1-0.5 microm diameter), not surrounded by trilaminar membranes, and granular with indistinct margins that blended with surrounding cytoplasm. Some contained 12+/-2-nm-diameter icosahedral virions in loose aggregates or rarely forming paracrystalline arrays. Small inclusions could be sites of viral assembly or maturation. Intracytoplasmic inclusions of the second type were larger (0.5-5.0 microm diameter) and more numerous and had abrupt margins surrounded by trilaminar membranes. They were more electron dense than small inclusions and were heterogeneous, containing various proportions of aggregated virions, electron-dense crystalline lamellae of 5 nm periodicity, and/or whorls of myelinoid membranes. Virions usually formed paracrystalline arrays and occasionally were loosely aggregated. Larger inclusions were typical of autophagolysosomes. Intranuclear inclusions were not membrane bound and were often associated with reticulated nucleoli or aggregates of heterochromatin. Some inclusions were irregularly shaped aggregates of indistinct, circular 10-12-nm-diameter viruslike particles. Others were 0.1-1.0 microm in diameter, round or ring shaped, dense, and finely granular, with sharply demarcated margins.  (+info)

Electron microscopical observations of psittacine beak and feather disease in an Umbrella cockatoo (Cacatua alba). (4/377)

Psittacine beak and feather disease (PBFD) was diagnosed in an umbrella cockatoo (Cacatua alba) with severe feather dystrophy and loss. Electron microscopically, the intranuclear and intracytoplasmic inclusion bodies observed by light microscopy were composed of viral particles forming paracrystalline arrays, whorls, semicircles or concentric circles. Recovered viral particles from the skin and feather follicle tracts were icosahedral and 15 to 20 nm in diameter.  (+info)

Detection of porcine circovirus from lesions of a pig with wasting disease in Japan. (5/377)

A wasting disease characterized by progressive weight loss and dyspnea has been observed in weaning pigs on a farm in Yamagata Prefecture in 1998. Histopathologic findings in an affected pig were bronchointerstitial pneumonia and intracytoplasmic clusters of basophilic inclusions in macrophages of lymph nodes, which were similar to those in pigs with postweaning multisystemic wasting syndrome (PMWS) recently reported in North America and Europe. Porcine circovirus (PCV)-like particles were observed in bronchial lymph node of the pig by electron microscopy, and PCV antigens were detected in the lesions by immunohistochemical staining. PCV DNA was also detected in the lung and tonsil by PCR, and restriction fragment length polymorphism analysis of the PCR products with HinfI showed the same type of the PCV associated with PMWS (pmws PCV). Homology of nucleotide sequences between the PCR product and corresponding regions of published pmws PCV genomes was very high. These results indicated that virus detected in this study was pmws PCV. To our knowledge, this is the first report on the presence of pmws PCV in Japan.  (+info)

Multiplex PCR for detection and typing of porcine circoviruses. (6/377)

Sets of oligonucleotide primers were designed according to the sequences of the open reading frames (ORFs) ORF1 and ORF2 of the prototype nonpathogenic PK-15 strain of porcine circovirus (PCV) type 1 (PCV-1). By the PCR performed with the various primer sets, genomic DNA or RNA from other bacterial or viral pathogens of the respiratory tracts of pigs could not be amplified. A positive amplification reaction could be visualized with DNA extracted from a viral suspension containing as few as 10 viral particles per ml. No DNA fragment could be amplified from lysates of continuous porcine cell lines (PT, ST, and PFT cells) known to be negative for PCV. When tested with clinical samples from pigs, the results of the single PCR method showed nearly 93% (13 of 14 samples) correlation with histopathological and immunohistochemical findings. Interestingly, subclinical PCV infections could be detected by single PCR with clinical samples that have been submitted from animals with irrelevant cases of respiratory and/or enteric problems. On the basis of the nucleotide sequences of PCV strains (PCV-2) recently associated with outbreaks of postweaning multisystemic wasting syndrome (PWMS) in Quebec, Canada, pig farms, other primers were designed from the PCV-1 genome, and these primers failed to amplify genomic fragments specific to the ORF1 or ORF2 genes of clinical isolates associated with PWMS but amplified DNA from the PCV-1 strain. Two rapid multiplex PCR (mPCR) methods have been developed to distinguish between both genotypes of PCV. By those two mPCR methods, (i) species-specific primer pairs were used to amplify a DNA fragment of 488 bp specific for the ORF2 genes of both genotypes, whereas a 375-bp fragment was amplified from the ORF1 gene of the PCV-1 strain only, or (ii) species-specific primer pairs were used to amplify a DNA fragment of 646 bp specific for the ORF1 genes of both genotypes, whereas a 425-bp fragment was amplified from the ORF2 gene of the PCV-1 strain only. By both mPCR methods, a PCV-2 infection was demonstrated in tissues of 94.2% (33 of 35) of the sick pigs tested, in agreement with previous findings showing the close association of this new genotype of PCV with outbreaks of PMWS in Europe and North America. On the other hand, a PCV-1 infection was confirmed in only 5.7% (2 of 35) of the pigs, and confirmation of a mixed infection with PCV-2 was obtained by a single PCR with PCV-2-specific primers.  (+info)

PCR detection and characterization of type-2 porcine circovirus. (7/377)

A polymerase chain reaction (PCR) assay was developed for detecting porcine circovirus (PCV). The assay readily detected type-2 PCV (PCV-2) and type-1 PCV (PCV-1). The PCR primers were designed based on DNA sequences conserved in all reported PCV genomes. Type 1 PCV and type 2 PCV both produced 438 bp amplification products, which were easily identified and differentiated from one another by restriction fragment length polymorphism (RFLP) analysis. Porcine circovirus was detected in 55% (931/1693) of randomly tested pigs with various clinical signs and lesions, most of which were difficult to differentiate from those associated with porcine reproductive and respiratory syndrome (PRRS). The PCR products from all positive clinical samples were identified by RFLP to be only PCV-2; DNA tested by PCR was extracted directly from one or more of lung, mesenteric or mediastinal lymph nodes, and tonsil. Type 2 PCV was also detected in 6% (2/34) of DNA extracted directly from semen of randomly chosen healthy boars. Positive PCR reactions from 554 diseased pigs were characterized by RFLP and categorized into 5 different profiles (A-E), of which 82.8% were PCV-2A (456/554), 3.0% were PCV-2B (17/554), 9.9% were PCV-2C (55/554), 1.1% were PCV-2D (6/554), and 3.2% were PCV-2E (18/554). The complete genomic nucleotide sequences of PCV-2A, B, C, D, and E were determined and found to have at least 95% homology compared with one another and with all other PCV-2 found in the GenBank database. All PCV-2 had less than 76% homology with PCV-1. This PCR assay will hopefully be useful to veterinary diagnostic laboratories for routine testing and surveillance of infection with PCV-2. The RFLP profiling system might be useful for preliminary characterization and identification of PCV isolates and might also benefit studies on the molecular epidemiology of PCV.  (+info)

Porcine circoviruses: a review. (8/377)

Porcine circoviruses (PCV) are small nonenveloped DNA viruses containing a unique single-stranded circular genome. Previously, no recognized link was found between PCV infection of pigs and disease, and PCV was considered a nonpathogenic agent. Over the last 5 years, a "novel" PCV, designated PCV2, has been associated with various disease syndromes in pigs, primarily postweaning multisystemic wasting syndrome (PMWS). Pigs with PMWS have a variety of clinical signs, including debility, dyspnea, palpable lymphadenopathy, diarrhea, and pallor or icterus. Lesions associated with the presence of PCV2 in a variety of cell types include lymphohistiocytic to granulomatous interstitial pneumonia, hepatitis, nephritis, myocarditis, enteritis, and pancreatitis. The lesions of PMWS have been reproduced experimentally after inoculation of piglets with PCV2 cell culture isolates, although the full expression of the disease syndrome may require the presence of other agents such as porcine parvovirus or porcine reproductive and respiratory syndrome (PRRS) virus. Recent reports have linked PCV2 to other disorders in pigs, ranging from abortion and reproductive failure to "atypical" PRRS. Available data indicate high seroprevalence of antibodies to PCV2 worldwide. The diagnosis of PCV2-associated disease is based on the direct demonstration of PCV2 antigens or nucleic acid in affected tissues. PCV2 is now regarded as an important emerging pathogen. Although vertical transmission has been documented, the epidemiology of PCV2 infections is poorly understood, as is the role of the immune response in controlling or augmenting disease.  (+info)

1. Meehan BM, McNeilly F, Todd D, Kennedy S, Jewhurst VA, Ellis JA, Hassard LE, Clark EG, Haines DM, Allan GM. Characterization of novel circovirus DNAs associated with wasting syndromes in pigs. J Gen Virol. 1998;79:2171-2179.. 2. Chae C. A review of porcine circovirus 2-associated syndromes and diseases. Vet J. 2005;169:326-336.. 3. Chae C. Postweaning multisystemic wasting syndrome: a review of aetiology, diagnosis and pathology. Vet J. 2004;168:41-49.. 4. Chae C. Commercial porcine circovirus type 2 vaccines: Efficacy and clinical application. Vet J. 2012;194:151-157.. 5. Chae C. Porcine circovirus type 2 and its associated disease in Korea. Virus Res. 2012;164:107-113.. 6. Fenaux M, Opriessnig T, Halbur PG, Elvinger F, Meng XJ. A chimeric porcine circovirus (PCV) with the immunogenic capsid gene of the pathogenic PCV type 2 (PCV2) cloned into the genomic backbone of the nonpathogenic PCV1 induces protective immunity against PCV2 infection in pigs. J Virol. 2004;78:6297-6303.. 7. Chow SC, ...
Porcine circovirus-associated diseases (PCVAD), caused by porcine circovirus type 2 (PCV2), threaten the pig industry worldwide. Five genotypes of PCV2 were recently identified: PCV2a, PCV2b, PCV2c, PCV2d and PCV2e. In addition, a novel porcine circovirus from a case of a sow with dermatitis, nephropathy syndrome and reproductive failure has been identified based on metagenomic analysis and classified as porcine circovirus type 3 (PCV3). Therefore, the current study was conducted to determine the prevalence and genetic characteristics of PCV2 and PCV3 in clinical samples. A total of 471 samples (161 tissue samples of lungs and lymph nodes from 34 farms and 310 serum samples from 47 farms) were tested for PCV2. Among them, 171 samples from 59 farms that had been positive for PCV2 were genotyped. Another 690 samples (296 tissue samples of lungs and lymph nodes from 91 farms, 108 samples of aborted foetuses from 26 farms, and 286 serum samples from 47 farms) were tested for PCV3. Based on PCV2 genotyping
TY - JOUR. T1 - Porcine circovirus type 2 (PCV2) infections: Clinical signs, pathology and laboratory diagnosis. AU - Segalés, Joaquim. PY - 2012/3/1. Y1 - 2012/3/1. N2 - Clinical signs and pathological features are still the corner-stones to suspect and diagnose overt disease associated with PCV2 infection. The clinico-pathological scope of this viral infection has been expanded over time. From the initial description of postweaning multisystemic wasting syndrome, some enteric, respiratory and reproductive disorders have been subsequently linked with PCV2. Porcine dermatitis and nephropathy syndrome, an immunocomplex disease, has also been associated with infection by this virus. All together, these conditions have been grouped under the name of porcine circovirus diseases (PCVD) or porcine circovirus associated diseases (PCVAD). The precise mechanisms by which a PCV2 infected pig develops a PCV2 subclinical infection or a clinical PCVD/PCVAD are still to be fully elucidated, but inferences ...
Porcine circoviral disease (PCVD) and Porcine circovirus associated disease (PCVAD), is a disease seen in domestic pigs. This disease causes illness in piglets, with clinical signs including progressive loss of body condition, visibly enlarged lymph nodes, difficulty in breathing, and sometimes diarrhea, pale skin, and jaundice. PCVD is very damaging to the pig-producing industry and has been reported worldwide. PCVD is caused by porcine circovirus type 2 (PCV-2). The North American industry endorses PCVAD and European use PCVD to describe this disease. Postweaning multisystemic wasting syndrome (PMWS) is the classic PCVD entity, caused by PCV-2. PCV-2 has a near universal distribution - present in most pig herds. In contrast, PMWS is more sporadic in its distribution. Experimental induction of PMWS has not been achieved by PCV-2 infection alone, using infectious DNA clones of the virus or a pure form of PCV-2 derived from infectious DNA clones. Therefore, it is assumed that PMWS is a ...
Porcine circovirus type 2 (PCV2) causes postweaning multisystemic wasting syndrome (PMWS) in growing pigs but generally requires the presence of other infectious or non-infectious factors to produce the full clinical expression of disease. These factors remain to be identified, but management routines, concurrent infections and maternal immunity are thought to influence the risk for PMWS outbreak in swine herds. Pigs presenting with PMWS develop severe immunosuppression and the work of this thesis focuses on the interaction between PCV2 and the immune system of the pig in vivo and in vitro. Development of PMWS was studied in models for experimental infection in young pigs using coinfections with porcine parvovirus (PPV) or Escherichia coli. Three-day-old colostrum-deprived pigs infected with PCV2 and PPV developed severe PMWS, and a possible role for interleukin 10 as well as impaired production of antibodies to PCV2 in the development of disease was observed. Four-week-old colostrum fed pigs ...
Porcine circovirus type 2 (PCV2) belongs to the family Circoviridae, and is the causative agent of post-weaning multisystemic wasting syndrome (PMWS) in pigs. In this study, phylogenetic analyses of three complete PCV2 genomic sequences from Hong Kong suggest that natural recombination happened among different lineages of PCV2. A preliminary investigation of the parental strains of these potential recombinants was carried out using bootscanning. Statistical significance of this recombination event was tested and positions of the potential recombination breakpoints were estimated in a maximum-likelihood framework. The recombinant breakpoints were estimated to be located within the origin of replication (ori) and replicase (rep) gene of PCV2. Interestingly, several GenBank sequences of PCV2 in mainland China were found to have a recombination pattern similar to that of the potential PCV2 recombinants from Hong Kong, implying that this recombinant genotype might already be widespread within ...
Porcine circovirus type 2 Capsid antibody for IHC, IHC-P, WB. Anti-Porcine circovirus type 2 Capsid pAb (GTX128120) is tested in Porcine circovirus type 2 samples. 100% Ab-Assurance.
Porcine circovirus type 3 (PCV3) is a newly emerging circovirus that might be associated with porcine dermatitis and nephropathy syndrome, reproductive failure, and cardiac and multisystemic inflammation. To aid the prevention and control of the infectious disease caused by PCV3, we developed a novel isothermal amplification assay using polymerase spiral reaction (PSR), which allows the visual detection of preserved strains and clinical samples. This assay precisely amplified the PCV3 genome with the use of a water bath at 62 °C for 50 min. The detection limit was found to be 1.13 × 102 copies/μL by gel electrophoresis or with the use of a visible dye (an indicator comprising phenol red and cresol red). No cross-reaction with other porcine infectious viruses was observed. The detection results for 23 PCV3-positive samples by PSR were in accordance with loop-mediated isothermal amplification (LAMP) assay. The detection rate of the PSR assay for PCV3 positivity of clinical samples was 68/97, which was
Baltimore Classification== ===Higher order taxa=== Viruses; ssDNA viruses; Circoviridae; Circovirus ===Species=== Beak and feather disease virus, Canary circovirus, Goose circovirus ==Description and Significance== Circoviruses are very small non-enveloped icosahedral viruses with a single stranded circular DNA genome. They have been described in pigs (porcine circovirus, PCV), chickens (chicken anemia virua, ChAV), psittacines (psittacine beak and feather disease virus, PBFD) and pigeons. The virus targets the lymphoid tissue and causes immunosuppression in the host. Circoviruses are the smallest pathogenic DNA viruses that have been identified and characterized in animals. ==Genome Structure== The genome of the circovirus is monomeric. It is unsegmented and contains a single molecule of circular, ambisense, sinle-stranded DNA that forms a covalently closed circle. The complete genome is 1800-2000 nucleotides long and the genome has a guanine+cytosine content of 48.4-53.1 %. (source: ...
Last week we discussed measures being taken in Europe for treatment and control of porcine circovirus type-2 (PCV-2). This week we will consider
TY - JOUR. T1 - Development of a polyclonal-antibody-based immunohistochemical method for the detection of type 2 porcine circovirus in formalin-fixed, paraffin-embedded tissue. AU - Sorden, Steven D.. AU - Harms, Perry A.. AU - Nawagitgul, Porntippa. AU - Cavanaugh, David. AU - Paul, Prem S.. PY - 1999/11. Y1 - 1999/11. N2 - An immunohistochemical method for the detection of type 2 porcine circovirus (PCV2) in paraffin-embedded tissue was developed. Rabbits were inoculated with purified PCV2 to obtain a polyclonal antiserum. Antiserum was applied to sections of porcine tissue that contained lesions consistent with postweaning multisystemic wasting syndrome and in which PCV2 genome had been demonstrated by in situ hybridization. In all cases (18/18), the density and distribution of positive cells detected by in situ hybridization or immunohistochemistry were identical. The immunohistochemical method is more rapid and less expensive than in situ hybridization and is thus more suitable for routine ...
Porcine circovirus type 2 (PCV2) is considered to be an important emerging pathogen associated with a number of different syndromes and diseases in pigs known as PCV2-associated diseases. It has been responsible for significant mortality among pigs and remains a serious economic problem to the swine industry worldwide leading to significant negative impacts on profitability of pork production. In this study we have demonstrated that PCV2 capsid (Cap) protein based virus-like particles (VLPs) were efficiently produced in yeast S. cerevisiae and induced production of monoclonal antibodies (MAbs) reactive with virus-infected cells. Moreover, PCV2 Cap VLPs served as a highly specific recombinant antigen for the development of an indirect IgG PCV2 Cap VLP-based ELISA for the detection of virus-specific IgG antibodies in swine sera. Four hundred-nine serum samples collected from pigs in Lithuania were tested for PCV2-specific IgG to determine the sensitivity and specificity of the newly developed ELISA in
IDENTIFICATION AND USE: Porcine circoviruses are small, icosahedral viruses that were discovered in 1974 as contaminants of a porcine kidney cell line. They were later called circoviruses when their genome was found to be a circular, single-stranded DNA molecule. Upon entry into cells, the viral ssDNA genome enters the nucleus where it is made double-stranded by host enzymes. It is then transcribed by host RNA polymerase II to form mRNAs that are translated into viral proteins. There is some evidence that circoviruses might have evolved from a plant virus that switched hosts and then recombined with a picorna-like virus.. Porcine circoviruses are classified in the Circoviridae family, which contains two genera, Circovirus and Gyrovirus. There are two porcine circoviruses, PCV-1 and PCV-2; only the latter causes disease in pigs. Infection probably occurs via oral and respiratory routes, and leads to various diseases including postweaning multisystemic wasting syndrome, and porcine dermatitis and ...
Porcine circovirus type 3 (PCV-3) had posed a potential threat to the swine industry since its discovery in the United States in 2015. The Shanxi province had a wide range of large-scale pig farms in China, but the transmission of PCV-3 was unclear. T
Porcine circovirus type 2 (PCV2) associated reproductive disease was diagnosed in a herd containing only gilts. A single case of abortion occurred and no other disorder was evident in the herd. PCV2 antigen and/or DNA were detected in two aborted fetuses. One of the fetuses, revealing both PCV2 DNA and antigen, presented multinucleated giant cells, severe vascular lesions (intramural oedema, fibrinoid necrosis, mild lympho-histiocytic vasculitis, fibrin thrombi) and mild non-suppurative inflammation in the lungs. Other abortifacient infections were not found. This is the only report of PCV2-induced abortion in Hungary since 1999, when PCV2-associated disease was first discovered in the country. ...
Porcine circovirus type 2 (PCV2) vaccination leads to reduced mortality, increased growth rate, inconsistent effects on feed efficiency and no impacts on carcass traits but the effects on nursery performance are product-dependent, according to Dr Steve Dritz of Kansas State University.
Coreplication of the major genotype group members of porcine circovirus type 2 as a prerequisite to coevolution may explain the variable disease ...
Open reading frame 2 (ORF2) of porcine circovirus type 2 (PCV2) codes for the 233 amino acid capsid protein (CP). Baculovirus-based vaccines that express only ORF2 are protective against clinical disease following experimental challenge or natural infection. The goal of this study was to identify regions in CP preferentially recognized by sera from experimentally infected and vaccinated pigs, and compare these responses to pigs diagnosed with porcine circovirus-associated disease (PCVAD). The approach was to react porcine sera with different CP polypeptide fragments that each contained one or more immunoreactive regions. Expression of polypeptides was performed using E.coli. Initial results showed that sera from vaccinated pigs preferentially recognized only the largest CP(43-233) polypeptide fragment and showed low levels of binding to other CP polypeptide fragments. The results of sera from pigs diagnosed with PMWS showed only minimal reactivity with CP polypeptide fragments, including the ...
Porcine circovirus type 2 (PCV2) is the primary causative agent of postweaning multisystemic wasting syndrome (PMWS), whereas the ubiquitous porcine circovirus type 1 (PCV1) is nonpathogenic for pigs. Since its initial detection in a Canadian commercial swine herd in 1991, PMWS has been detected in all swine producing regions of the world and is now a serious economic problem to the swine industry. The objectives of this dissertation were to biologically, genetically and experimentally characterize both PCV1 and PCV2, to identify the genetic determinant(s) for virulence and replication, and to develop an effective genetically-engineered vaccine against PCV2 infection and PMWS. The genetic heterogeneity of PCV2 and PCV1 isolates from different geographic origins were determined. We found that, although PCV1 and PCV2 genomes were very conserved, some minor genomic variation exists among PCV1 isolates and PCV2 isolates. The nonpathogenic PCV1 and pathogenic PCV2 share only about 76% nucleotide ...
The Duck circovirus (DuCV) is a type of virus found in ducks. Strains of the virus have predominantly been found in China, though strains have also been isolated from ducks in Germany and the United States. Duck circovirus is a small nonenveloped virus with a monomeric single-stranded circular DNA genome. DuCV has been clustered in the Circoviridae family genus Circovirus, according to the eighth report of the International Committee on Taxonomy of Viruses. Scientists have studied the Duck circovirus by using polymerase chain reaction (PCR)-based methods and dot blot hybridisation (DBH) tests. Infection with DuCV appears to cause growth disorders in ducks as well as eventual immunosuppression due to depletion of lymphatic cells. It was found that ducks between the ages of 40∼60 days were more susceptible to Duck circovirus. There was no evidence showing that the DuCV virus was capable of vertical transmission. The symptoms are immunosuppression, stunting in growth, and also feather ...
Porcine circovirus 2 (PCV2) is the primary cause of post-weaning multisystemic wasting syndrome, in which it stimulates a strong IL-8 response that is associated with chronic inflammation as well as lesions in the lymphoid organs. However, the mechanism underlying PCV2-induced IL-8 production is still unclear. In the present study, we demonstrated that increased IL-8 expression during PCV2 infection depends on Toll-like receptor (TLR2), but not TLR4 or TLR9 signalling pathways in porcine alveolar macrophages. Moreover, we found that impairment of the MyD88/NF-κB signalling pathway by MyD88 knockdown or NF-κB inhibitors markedly decreased PCV2-induced IL-8 secretion. These results suggest that PCV2 induces IL-8 secretion via the TLR2/MyD88/NF-κB signalling pathway. Therefore, it is important to elucidate the molecular mechanisms of the PCV2-induced inflammatory response.
1111767DNAPorcine circovirus 1accagcgcac ttcggcagcg gcagcacctc ggcagcacct cagcagcaac atgcccagca 60agaagagtgg aagaagcgga ccccaaccac ataaaaggtg ggtgttcacg ctgaataatc 120cttccgaaga cgagcgcaag aaaatacggg agctcccaat ctccctattt gattatttta 180ttgttggcga ggaaggtaat gaggagggcc gaacacccca cctacagggg ttcgctaatt 240ttgtgaagaa gcaaactttt aataaagtga agtggtattt tggtgcccgc tgccacatcg 300agaaagcgaa aggaacagat cagcagaata aagaatattg cagtaaagaa ggcaacttac 360tgatagaatg tggagctcct agatctcaag gacaacggag tgacctctct actgctgtga 420gtaccttgtt ggagagcggg agtctggtga ccgttgcaga gcagcaccct gtaacgtttg 480tcagaaattt ccgcgggctg gctgaacttt tgaaagtgag cgggaaaatg cagaagcgtg 540attggaagac gaatgtacac gtcattgtgg ggccacctgg gtgtggcaaa agcaaatggg 600ctgctaattt tgcagacccg gaaaccacat actggaaacc acctagaaac aagtggtggg 660atggttacca tggtgaagaa gtggttgtta ttgatgactt ttatggctgg ctgccgtggg 720atgatctact gagactctgt gatcgatatc ctttgactgt tgagactaaa ggtggaactg 780tacctttttt ggcccgcagt attctgatta ccagcaatca gaccccgttg gaatggtact 840cctcaactgc ...
Two types of porcine circovirus (PCV) exist, referred to as PCV1 and PCV2. PCV2 has been associated with disease syndromes in pigs, including that designated postweaning multisystemic wasting syndrome (PMWS), which has been identified in all regions of the world bar Australia (Hamel et al., 1998; Allan et al., 1999a; Onuki et al., 1999; Martelli et al., 2000; Kyriakis et al., 2000; Wellenberg et al., 2000; Done et al., 2001; Trujano et al., 2001; Saradell et al., 2004; Castro et al., 2004; Jemersic et al., 2004; Maldonado et al., 2004; Wang et al., 2004; Motovski and Segales, 2004; Garkavenko et al., 2005). PMWS affects young weaner pigs and results in weight loss, tachypnea, dyspnea, enlarged lymph nodes and jaundice (Harding, 1998). PCV2 may also cause or contribute to other swine diseases such as congential tremors (CT) (Stevenson et al., 1999), porcine dermatitis and nephropathy syndrome (PDNS) (Rosell et al., 2000), reproductive failure (Meehan et al., 2001) and several other emerging ...
The present invention provides a novel chimeric porcine circovirus infectious DNA clone and live attenuated chimeric virus with the PCV2, preferably of subtype PCV2b, capsid gene integrated into a non
Supplementary MaterialsS1 Document: Protocol (Danish). patients. Five-hundred and eighty-eight positive patients had been assessed for eligibility, which 559 had been excluded ahead of randomization. The Mouse monoclonal to MYST1 three significant reasons for exclusion had been duration of diarrhoea much longer than 21 times (n = 124), prior antibiotic treatment (n = 113), and co-pathogens in stools (n = 87). For that reason, 24 sufferers finished the trial with either azithromycin (n = 12) or placebo (n = 12). Both groupings provided symptoms of gentle, prolonged diarrhoea with a mean duration of 18 times (95% CI: 16C19). One individual in the azithromycin group and four from the placebo group thought we would continue with crossover medicine after the preliminary ten-time period. In the azithromycin group, there is a mean of a week (95% CI: 5C9) to scientific treat and for the placebo group it had been ten days (95% CI: 6C14) (OR3 (95% CI: -7C1). We observed no distinctions in every examined ...
article{326621, abstract = {Stimulation of the porcine immune system causes increased replication of porcine circovirus 2 (PCV2) in vivo. In the present study, we investigated whether various cytokines (interleukin-1 [IL-1], IL-6, IL-10, tumor necrosis factor-alpha [TNF-alpha], interferon-alpha [IFN-alpha], and IFN-gamma) are able to influence PCV2 infection in vitro. No changes were observed in IL-1, IL-6, TNF-alpha, or IL-10-treated cells. However, it was demonstrated that IFN-alpha and IFN-gamma influenced PCV2 infection in porcine kidney cells (PK-15) and porcine monocytic cells (3D4/31). IFN-gamma added to the culture medium before, during, or after inoculation increased the number of PCV2 antigen-positive cells, respectively, by 418%, 171%, and 691% in PK-15 cells and by 706%, 114%, and 423% in 3D4/31 cells. IFN-alpha pretreatment decreased the number of infected PK-15 cells. When it was added after inoculation, IFN-alpha enhanced PCV2 infection by 529% in PK-15 cells and by 308% in 3D4/31 ...
The study conducts the first phylogenetic analysis of PCV2 in Chile. PCV2 isolated from Chilean intensive swine farms, covering over the 90% of the pork production, resulting a complete national perspective of PCV2. The results confirm the high presence of PCV2b (52%) and less represented PCV2a (14%). Surprisingly, 34% of sequences were PCV2a/PCV2d recombinant viruses. The no amplification of these 10 sequences by the selective PCR was further explained due to these primers were not able to amplified PCV2d, the major parenteral of these viruses. Furthermore, we were not able to detect PCV2d variant in the Chilean PCV2 diversity even if was the major parent of the recombinant viruses, probably this event occurred years before and the recombinant remained. PCV2a and PCV2b, and the recombinant viruses were found since 2005. Nevertheless, were not observed geographical, temporal and other patterns, most likely due to there is not enough sequences per farm.. Recently, a large-scale study determinates ...
1. National Center for Animal Health Surveillance. National Animal Health Monitoring Survey 2000. Available at: www.aphis.usda.gov/vs/ceah/cahm. Accessed January 12, 2006. 2. Halbur PG. Defining the causes of PRDC. Swine Consultant. 1996;fall:4-15. 3. Opriessnig T, Thacker EL, Yu S, Fenaux M, Meng X-J, Halbur P. Experimental reproduction of postweaning multisystemic wasting syndrome in pigs by dual infection with Mycoplasma hyopneumoniae and porcine circovirus type 2. Vet Pathol. 2004;41:624-640. 4. Thacker EL, Halbur PG, Ross RF, Thanawongnuwech R, Thacker B. Mycoplasma hyopneumoniae potentiation of porcine reproductive and respiratory syndrome virus-induced pneumonia. J Clin Microbiol. 1999;37:620-627. 5. Hsu FS, Yeh TP, Lee CT. Tiamulin feed medication for the maintenance of weight gains in the presence of mycoplasmal pneumonia in swine. J Anim Sci. 1983;57:1474-1478. 6. Hannan PC, Goodwin RF. Treatment of experimental enzootic pneumonia of the pig by norfloxacin or its 6-chloro analogue. Res ...
Porcine Circovirus 2 (PCV2) has been intriguing pig producers and scientists alike as it proved difficult to identify both the disease's origins and triggers. In this third episode of the series 'PCVD - From pathogenesis to protection', Pig Progress launches an attempt to unveil as many mysteries as possible that surround PCV2.
12.Dan Xu, Qian Du, Cong Han, Zengguo Wang, Xiujuan Zhang, Tongtong Wang, Xiaomin Zhao, Yong Huang, Dewen Tong*, p53 signaling modulation of cell cycle arrest and viral replication in porcine circovirus type 2 infection cells. Veterinary Research, 2016. 47(1): p. 120-131.. 13.Hongling Zhang, Yong Huang, Lili Wang, Tingting Yu, Zengguo Wang, Lingling Chang, Xiaomin Zhao, Xiaomao Luo, Liang Zhang, Dewen Tong*, Immortalization of porcine placental trophoblast cells through reconstitution of telomerase activity. Theriogenology, 2016. 85(8): p. 1446-1456.. 14.Delong Li, Yong Huang, Qian Du, Zhenyu Wang, Lingling Chang, Xiaomin Zhao, Dewen Tong*, CD40 Ligand and GMCSF coexpression enhance the immune responses and protective efficacy of PCV2 adenovirus vaccine. Viral Immunology, 2016. 29(3): p. 148-158.. 15.Xiaomin Zhao, Hailing Xiang, Xiaoyuan Bai, Naijiao Fei, Yong Huang, Xiangjun Song, Hongling Zhang, Liang Zhang, Dewen Tong*, Porcine parvovirus infection activates mitochondria-mediated apoptotic ...
Animal circoviruses belong to the Circovirus genus of the Circoviridae family. Nowadays, only swine and birds were identified as circovirus hosts. Circoviruses have a single-stranded circular genome of approximately 2000 nucleotide long. DNA of these viruses possesses : (i) a nonanucleotide sequence essential for replication, flanked by inverted repeat sequences, a palindrome that has the potential to form a stem-loop structure and (ii) two major ORFs, located on the viral and complementary strands, which encode respectively the replication-associated protein (Rep) and the capsid protein (Cap). All the circoviruses described at the present time, except porcine circovirus of type 1, are associated with immunosuppressive or immunodepressive diseases. Histopathological lesions such as cytoplasmic inclusions of virus in histiocytic cells and T and B lymphocyte depletion in lymphoid organs, are commonly noticed. No medical prophylaxis of circovirus infections is currently available.. ...
Combination vaccine gives swine industry effective, convenient option. FLORHAM PARK, N.J., Aug. 20, 2014 - Fostera™ PCV MH - the porcine circovirus (PCV) and Mycoplasma hyopneumoniae (M. hyo) combination vaccine that was built from the ground up by Zoetis - now has the longest demonstrated duration of immunity (DOI) to help protect pigs from porcine circovirus-associated disease (PCVAD) caused by PCV Type 2 (PCV2). The U.S. Department of Agriculture has granted the combination vaccine the extended label claim of at least 23 weeks of protection against PCV2, which is three weeks longer than any other PCV2 vaccine on the market.. PCVAD continues to be one of the most economically harmful swine diseases. Affected pigs suffer from progressive weight loss, increased mortality and other clinical impacts, which takes a toll on producers productivity and profitability, said Darrell Neuberger, DVM, Pork Technical Services, Zoetis. Now, with a vaccine that offers at least 23 weeks of immunity, ...
In 2016, two small-scale fattening pig farms (about 200 or 300 American Landrace pigs in total), locating in Guangdong province (southern China) and Jilin province (northern China) separated by more than 3, 000 km in distance (Fig. 1), suffered from severe respiratory disease (SRD). Pigs (2-3 months old) on both farms have received immunizations against PCV2, pseudorabies virus (PRV), classical swine fever virus (CSFV) and type 2 porcine reproductive and respiratory syndrome virus (PRRSV). However, the morbidity rate of pigs on the two farms was approximately 60%, the mortality in affected pigs was about 80%. From autopsy results of 18 individual dead pigs (n = 8 for farm A, n = 10 for farm B) (Additional file 1: Table S1), the similar macroscopic lesions were concentrated in the lungs and lymph nodes, which was characterized by PRRSV- or PCV2-like lesions including pulmonary interstitial widening, congestion and lymphadenopathy bleeding. These 18 pig lung samples were defined as the samples ...
PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
Canine Circovirus (CanineCV) is an emerging virus which since its first report in USA in 2012, it has been described worldwide. It was the second mammalian circovirus species identified in dogs and its role in canine enteritis is still being uncertain as much as its association in disease with the Canine Parvovirus-2 (CPV-2). Here, we aim to confirm for the first time the presence of CanineCV in Colombia and to develop phylogenetic evolutive analyses of CanineCV in CPV-2 positive animals. DNA from samples were extracted and PCR, full genome sequencing and phylogenetic analysis was performed to detect and characterize CanineCV. From a total of 30 CPV-2 positive samples, 16.6% (n = 5) were positives for CanineCV. Sequencing analysis of Colombian CanineCV wild-type strains displayed high identity to each other (99.5-99.7% nt; 99.7% aa). The full genome phylogenetic analysis confirmed that worldwide reported CanineCV strains were separated into four distinct genotypes in addition to a European origin of the
A long-established epidemic of enteritis, caused by an unidentified pathogen distinct from parvovirus, has now been recognized in mink. In 2013, we identified a novel circovirus by degenerate PCR and fully sequenced its genome. This virus differs substantially from currently known members of the genus Circovirus and represents a new species.
Background Diarrhea is one of the most common clinical symptoms reported in companion animal clinics. Dog circovirus (DogCV) is a new mammalian circovirus that is considered to be a cause of...
posted April 1, 2008 Boehringer Ingelheim Vetmedica Inc. again requests proposals for studies investigating porcine circovirus-associated
Read Genetic characterization of type 2 porcine circoviruses detected in Hungarian wild boars, Archives of Virology on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
MHYOSPHERE® PCV ID is the first intradermal & needle-free vaccine against M.hyo & Circovirus PCV2, all in one and ready-to-use in swine.
Zoetis launched Fostera PCV MH on the US market. The vaccine is a one-bottle, one-dose combination vaccine that helps protect swine from Porcine Circovirus-associated disease (PCVAD) and enzootic pneumonia caused by Mycoplasma hyopneumoniae (M. hyo).
Vol 10: High yield production of pigeon circovirus capsid protein in the E. coli by evaluating the key parameters needed for protein expression.. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Ohio Ag Dept issued warning on Canine Circovirus, a contagious disease that has spread, killing 6 more dogs, but is there more to be feared than this virus …
Protection Against Evolving Virus. DURHAM, N.C., March 3, 2018 - Zoetis has introduced Fostera® Gold PCV MH, the U.S. pork industrys first vaccine to include two genotypes of porcine circovirus type 2 (PCV2) - 2a and 2b.. Together, the two genotypes provide the broadest range of protection against evolving PCV2 viruses in U.S. swine herds. The vaccines efficacy against 2d - the most prevalent PCV2 genotype - was demonstrated in a large field trial.. Were pleased to introduce a vaccine that brings real value to the U.S. pork industry - one that provides broader protection against PCV2 genotypes and, more importantly, helps to minimize performance problems due to the virus, reduce monetary losses for producers and benefit animal welfare, said Lucina Galina, DVM, PhD, director, swine technical services, Zoetis.. The duration of immunity (DOI) with Fostera Gold PCV MH is at least 23 weeks for PCV and Mycoplasma hyopneumoniae (M. hyo), which means the vaccine will protect most herds through the ...
El present treball es centra en lestudi de la producció de proteïnes recombinants en línies cel·∙lulars de mamífer. Concretament, sha realitzat lestudi de tres estratègies de bioprocés, totes elles basades en el cultiu de cèl·∙lules HEK293. Com a proteïna model per a lexpressió de proteïnes heteròlogues sha triat la proteïna CapPCV2, la qual conforma la càpsida viral del Circovirus porcí serotip 2 (PCV2). Aquest virus és lagent causal de PCVDS (porcine circovirus diseases o malaties derivades de circovirus porcí). Aquest terme engloba un conjunt de malalties i síndromes que tenen un elevat impacte econòmic en la indústria porcina. El projecte sha enfocat des de la perspectiva de desenvolupament i optimització del bioprocés i, en conseqüència, lincrement de la producció volumètrica ha estat la força impulsora de tot el treball. En primer lloc es presenten els estudis per a la selecció del medi de cultiu i suplements nutricionals. El creixement cel·∙lular
Porcine diseases associated with porcine circovirus 2 (PCV-2) infection have resulted in significant economic losses worldwide. A real-time recombinase polymerase amplification (RPA) assay was develop
Whats your diagnosis #3 Porcine Multisystemic Wasting Syndrome - PCV-2 See original post here History: A feeder pig was found dead in the morning, it was thinner than its penmates. Gross Necropsy: (no photos) The lungs were loosely adhered to the thoracic body wall by multiple strands of fibrin. The lungs were diffusely edematous and firm. The…
Read Increased yield of porcine circovirus-2 by a combined treatment of PK-15 cells with interferon-gamma and inhibitors of endosomal-lysosomal system acidification, Archives of Virology on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
A blinded interlaboratory assessment of the diagnostic agreement and accuracy of serologic tests for routine detection of antibodies against Porcine circovirus-2 (PCV-2), including indirect fluorescent antibody tests (IFATs) and enzyme-linked immunosorbent assays (ELISAs) was conducted in 7 North American laboratories.
TY - JOUR. T1 - Particles resembling circovirus in the bursa of Fabricius of pigeons.. AU - Shivaprasad, H L. AU - Chin, Richard P. AU - Jeffrey, J. S.. AU - Latimer, K. S.. AU - Nordhausen, R. W.. AU - Niagro, F. D.. AU - Campagnoli, R. P.. PY - 1994/7. Y1 - 1994/7. N2 - Histological examination of the bursae from 12 pigeons under 4 months old revealed basophilic globular inclusion bodies, 5 to 25 microns in diameter, in the cytoplasm and the nuclei of the various bursal follicular cells. Electron microscopy of these inclusions revealed large electron-dense areas containing non-enveloped icosahedral viral particles, 14-19 nm in diameter, either loosely arranged or in paracrystalline array. Similar basophilic globular inclusion bodies were seen in the spleen and cecal tonsils of a few pigeons and in the duodenum of one pigeon. There were various degrees of lymphoid depletion in the bursa, spleen, and bone marrow. The morphology of the inclusions in the bursa and size of the viral particles are ...
Swine vaccine for use in healthy swine as an aid in the prevention of viremia, as an aid in the reduction of virus shedding, as an aid in the reduction of lymphoid infection caused by Porcine Circovirus Type 2 (PCV2), and as an aid in the reduction of lung lesions due to Mycoplasma hyopneumoniae. Demonstrated PCV2 efficacy for at least 20 weeks following completion of vaccination. Circumvent PCV M G2 is the reliable 1-dose RTU combo vaccine for PCV2 and mycoplasmal pneumonia, making it easier than ever to vaccinate for each disease. Even better, this next-generation vaccine can be used on young pigs when theyre easier to handle. Start your pigs off right and improve your bottom line from the very beginning with Circumvent PCV-M G2. ...
Synonyms for AIDS wasting syndrome in Free Thesaurus. Antonyms for AIDS wasting syndrome. 1 synonym for AIDS: acquired immune deficiency syndrome. What are synonyms for AIDS wasting syndrome?
The Respiratory Disease Research Board (formerly the PRRS Research Review Board), with financial support from Boehringer Ingelheim Vetmedica, Inc. (BIVI), is pleased to announce an expansion of the Research Award program to include additional respiratory pathogens.. Beginning in 2016, the Awards for Advancing Research in Respiratory Disease (formerly PRRS Research Awards) will also be open to research projects related to porcine circovirus Type 2 (PCV2), Mycoplasma hyopneumoniae and influenza A virus in swine (IAV-S). This is the first time in the boards history that projects covering diseases beyond PRRS will be considered.. We recognize that there are a host of other respiratory disease challenges besides PRRS that impact production and performance, says Dr Daryl Olsen, AMVC veterinarian and member of the Respiratory Disease Research Board.. This expansion is exciting because it shows our commitment to meeting the industrys broad needs for ongoing, applicable swine respiratory disease ...
Con la intención de unificar la terminología para referirse a cada una de estas enfermedades y al conjunto de ellas, se ha propuesto recientemente el término PCVD para referirse al conjunto de enfermedades asociadas a PCV2, y la terminología que figura en la tabla para referirse a cada una de las PCVD (Segalés, 2012). En cuanto a la enfermedad reproductiva por PCV2, cabe añadir que recientemente se ha vinculado PCV2 a SMEDI (S-stillbirth-nacidos muertos, M-mummification-momificación, ED-embryonic death-muerte embrionaria e I-infertility-infertilidad) en primíparas (Meyns y col., 2012). Otra enfermedad que todavía hoy se sigue asociando al virus es el síndrome de dermatitis y nefropatía porcino, a pesar de considerarse una enfermedad mediada por immunocomplejos de la que no se ha demostrado claramente su etiología (Allan y col., 2000a; Rosell y col., 2000; Wellenberg y col., 2004). En los últimos años se está considerando también el impacto de la infección subclínica de los ...
Both Rotarix and RotaTeq are designed to protect infants from gastrointestinal illness caused by rotavirus, which kills more than 500,000 infants each year, mostly in low- and middle-income countries. Deaths are rare in the United States, but illness can require a hospital stay due to severe diarrhea. The oral vaccines are typically given to infants between two and six months of age in a two- or three-dose series.. * Read: Ensure Children Receive Vaccinations Before School Starts. An advisory panel for the FDA found that the risk to humans from the porcine (pig) circovirus type 1, or PCV1, was theoretical. Millions of doses of the vaccines have been given to infants with no sign of significant safety problems and PCV1 is not even known to cause health problems in pigs.. Another strain of the virus, PCV2, is believed to cause a wasting syndrome in young piglets, marked by diarrhea and an inability to gain weight, but it is not known to injure humans. Only PCV1 was detected in the Rotarix vaccine, ...
Diagnostic experts: PCV3 is common in US swine herds-Qilu Animal Health Products Co., Ltd-Porcine circovirus type 3 (PCV3) was first reported in 2016, but appears to have been present in swine populations decades prior to that time, said Bailey Arruda, DVM, a diagnostic pathologist at Iowa
Recent findings by Professor of Cell and Developmental Biology David Bilder and his lab could lead to the development of much-needed targeted therapies for wasting syndrome in cancer patients (this syndrome is called cachexia, where muscle and fat tissues are destroyed throughout the body). Read more...
The Report Swine Diseases Treatment Market - Global Industry Trend Analysis 2012 to 2017 and Forecast 2017 - 2025 provides information on pricing, market analysis, shares, forecast, and company profiles for key industry participants. - MarketResearchReports.biz
The CDC National Center for HIV, STD, and TB Prevention provides the following information as a public service only. Providing synopses of key scientific ...
The AVMA House of Delegates is set to consider a resolution to increase member dues in 2011 so that the Association can continue to provide
A third of cancer patients die from a wasting syndrome. With new hints, researchers are closing in on what causes it and how to slow it down in order to give cancer patients more time to fight.
Ellis, J (2014). "Porcine circovirus: A historical perspective". Veterinary Pathology. 51 (2): 315-27. doi:10.1177/ ...
The family Circoviridae contains two genera-Circovirus and Cyclovirus. Genus Circovirus: type species: Porcine circovirus 1 ... A stem loop structure with a conserved nonanucleotide motif is located at the 5' intergenic region of circovirus genomes and is ...
Genus Circovirus. *Genus Cyclovirus. *Familie Geminiviridae (ssDNA(+/-): die einzelnen Gene haben unterschiedliche Polarität) ...
A circovirus-given the name raven circovirus or RaCV-was isolated from an Australian raven suffering from feather lesions in ... It has affinities with canary circovirus (CaCV) and pigeon circovirus (PiCV). Its clinical significance is unknown. Tick ... Stewart, Meredith E.; Perry, Ross; Raidal, Shane R. (2006). "Identification of a novel circovirus in Australian ravens (Corvus ...
Some CRESS viruses are known pathogens, such as porcine circovirus type 2 Redondoviruses have been reported associated with ... "Porcine Circovirus Type 2 (PCV2): Pathogenesis and Interaction with the Immune System". Annual Review of Animal Biosciences. 1 ...
PRRS, Circovirus, and clostridial enteritis, among others, can be present in these systems. Crowding, mixing of groups, and ...
Examples of viruses carried by pigs include porcine herpesvirus, rotavirus, parvovirus, and circovirus. Of particular concern ...
Postweaning multisystemic wasting syndrome has been causally associated with porcine circovirus type 2. The Iotatorquevirus ...
It has a low level of homology to the Circovirus chicken anemia virus. The virus can be isolated from the blood and all the ...
For example, Porcine circovirus type 1 has a genome of 1759 nucleotides and a capsid diameter of 17 nm. As a whole, the viral ... Porcine circovirus 2 Archived July 4, 2007, at the Wayback Machine K. Rosario; R.O. Schenck; R.C. Harbeitner; S.N. Lawler; M. ...
... is a veterinary recombinant vaccine for porcine circovirus type 2 (PCV 2). It is manufactured by German ...
Examples of viruses carried by pigs include porcine herpesvirus, rotavirus, parvovirus, and circovirus. Porcine herpesviruses ... and rotaviruses can be eliminated from the donor pool by screening, however others (such as parvovirus and circovirus) may ...
... stated that there were indications that the pigs carried porcine circovirus. Porcine circovirus, he said, was spread among pigs ... The BBC reported that some pig corpses were infected by porcine circovirus, in line with comments from Lu Hongzhou, Secretary ... "No matter the strain, avian flu has never had any connection to porcine circovirus." However, the pigs themselves could serve ...
A study of horseshoe and vesper bats in China identified circoviruses from the genera Circovirus and Cyclovirus. Several kinds ... "Genomic characterization of a novel bat-associated Circovirus detected in European Miniopterus schreibersii bats". Virus Genes ...
April 2018). "Presence of Torque teno sus virus 1 and 2 in porcine circovirus 3-positive pigs". Transboundary and Emerging ... caused by Porcine circovirus type 2 (PCV2). However, it is still unclear whether the co-infection contributes to the PMWS or ... "Clinical aspects and weight gain reduction in swine infected with porcine circovirus type 2 and torque teno sus virus in Brazil ...
Zhou Y, Qi B, Gu Y, Xu F, Du H, Li X, Fang W (February 2016). "Porcine Circovirus 2 Deploys PERK Pathway and GRP78 for Its ... CHOP-induced apoptosis pathways had been identified in cells infected by Porcine circovirus type 2 (PERK-eIF2α-ATF4 -CHOP-BCL2 ...
The virus causing PBFD was initially designated as psittacine circovirus but has since been renamed beak and feather disease ... Although there has been debate in the literature concerning the role of vertical transmission of avian circovirus, BFDV is ... The causative virus-beak and feather disease virus (BFDV)-belongs to the taxonomic genus Circovirus, family Circoviridae. It ... The virus was originally designated PCV (psittacine circovirus), but has since been renamed beak and feather disease virus. ...
Circovirus porcino tipo 1 1.759 1,8kb Virus máis pequeno que se replica autonomamente en células eucarióticas.[14] ...
Divalent Metal and DNA Binding of the Endonuclease Domain from the Replication Initiation Protein from Porcine Circovirus 2". ...
... the rapid and complete selective sweep of a circovirus in the endangered echo parakeet". Journal of Virology. 86 (9): 5221-5229 ...
The virus was named BSL-RDHV (Boiling Spring Lake RNA DNA Hybrid Virus). Its genome is related to a DNA circovirus, which ...
2003). "Comparison of the structures of three circoviruses: Chicken anemia virus, porcine circovirus type 2, and beak and ...
... pigeon circovirus, canary circovirus, goose circovirus. Herpesviruses are ubiquitous pathogens infecting a variety of animals, ... There are to genera: gyrovirus, with one species called chicken anemia virus; and circovirus, which includes porcine circovirus ...
... the first human circovirus". J. Virol. 73 (5): 3582-3586. doi:10.1128/JVI.73.5.3582-3586.1999. PMC 104131. PMID 10196248. "AABB ...
... the first human circovirus". J. Virol. 73: 3582-3586. "AABB website" (PDF). Retrieved December 25, 2017. Biagini, P.; Gallian, ...
Porcine epidemic diarrhea virus Porcine reproductive and respiratory syndrome virus Porcine circovirus Porcine parvovirus This ...
On March 22, 2010, the detection of DNA from porcine circovirus types 1 and 2 within RotaTeq and Rotarix prompted the FDA to ... stating that porcine circovirus types 1 and 2 pose no safety risks in humans and concluded that health risks involved did not ... suspend the use of rotavirus vaccines while conducting an investigation the finding of DNA from porcine circovirus-1 (PCV1) in ...
... leptospira QI09AL08 Porcine circovirus + mycoplasma QI09AM01 Escherichia antiserum QI09AM02 Pasteurella antiserum QI09AM03 ... virus QI09AA06 Classical swine fever virus QI09AA07 Porcine circovirus QI09AB01 Treponema QI09AB02 Escherichia QI09AB03 ...
Chlorovirus Chordovirus Chosvirus Christensenvirus Chunghsingvirus Cilevirus Cimpunavirus Cinunavirus Circovirus Citexvirus ...
PCVD is caused by porcine circovirus type 2 (PCV-2). The North American industry endorses "PCVAD" and European use "PCVD" to ... Porcine circoviral disease (PCVD) and Porcine circovirus associated disease (PCVAD), is a disease seen in domestic pigs. This ... Opriessnig, Tanja; Meng, Xiang-Jin; Halbur, Patrick G. (2007-11-01). "Porcine circovirus type 2 associated disease: update on ... Opriessnig, T; Langohr I (January 2013). "Current state of knowledge on porcine circovirus type 2-associated lesions". ...
... circovirus 1 Civet circovirus Duck circovirus European catfish circovirus Finch circovirus Goose circovirus Gull circovirus ... Pigeon circovirus Porcine circovirus 1 Porcine circovirus 2 Porcine circovirus 3 Raven circovirus Rodent associated circovirus ... Barbel circovirus Bat associated circovirus 1 Bat associated circovirus 2 Bat associated circovirus 3 Bat associated circovirus ... Swan circovirus Tick associated circovirus 1 Tick associated circovirus 2 Zebra finch circovirus Viruses in Circovirus are non- ...
The Duck circovirus (DuCV) is a type of virus found in ducks. Strains of the virus have predominantly been found in China, ... Duck circovirus is a small nonenveloped virus with a monomeric single-stranded circular DNA genome. DuCV has been clustered in ... It was found that ducks between the ages of 40∼60 days were more susceptible to Duck circovirus. There was no evidence showing ... A vaccine to provide protection against Duck circovirus has not been approved for use, though research to create one has ...
(2009) Rosario et al. Journal of General Virology. Single-stranded DNA (ssDNA) viruses with circular genomes are the smallest viruses known to infect eukaryotes. The present study identified 10 novel genomes similar to ssDNA circoviruses through da...
I suspect the problem could be circo virus, it can cause young pigeons to have a bad immunity. I also suspect circovirus could ... The circovirus itself doesnt make the bird ill, other infections do. In your case I suspect there could also have been kidney ... Dear Sir, I started breeding pigeons again after 10 years and it was all ok but in the middle of july i suffered from the CIRCO VIRUS ... Is there any adenovirus and herpesvirus vaccines available for pigeons? Can we use circovirus and pox vaccines for chickens? Is ...
General facts about dog circovirus (DogCV); diseases associated with this viral disease; signs, management and prognosis for ... Dogs infected with circovirus have been reported in California and circovirus may be associated with recent illness and death ... Circovirus in Tissues of Dogs with Vasculitis and Hemorrhage. *Genomic Characterization of a Circovirus Associated with Fatal ... Dog Circovirus. Canine enteritis can be caused by a number of viral, bacterial or parasitic agents. The most common viral ...
Beak and feather disease virus, Porcine circovirus 1, Porcine Circovirus 2, Canary circovirus, Goose circovirus, seven ... Reproduction Cycle of a Circovirus in a Host Cell. In case of the Porcine circovirus type 1 (PCV1), the rep gene directs the ... Virion Structure of a Circovirus. The virions of a circovirus consist of a capsid that is enveloped. Virions have an ... Circovirus. From MicrobeWiki, the student-edited microbiology resource. Revision as of 14:47, 29 June 2006 by Mschlemm. (talk ...
again requests proposals for studies investigating porcine circovirus-associated ... again requests proposals for studies investigating porcine circovirus-associated disease.. The company created the PCVAD ...
What exactly is circovirus, and what steps can you take to ensure your dog doesnt catch it? This article debunks the myths. ... What exactly is circovirus, and what steps can you take to ensure your dog doesnt "catch" it?. Many people are worried about ... One difference with circovirus is that it may cause vascular problems, so veterinarians do need to be aware of that potential. ... When looked for in one study, Circovirus was found in 19 of 198 dogs with diarrhea, and 14 of 204 dogs. Most stools had ...
Rabbit polyclonal Porcine circovirus antibody. Validated in WB, IHC. Independently reviewed in 1 review(s). Immunogen ... Primary - Rabbit Anti-Porcine circovirus antibody (ab183908) IHC-P, WB Secondary - Goat Anti-Rabbit IgG H&L (HRP) (ab205718) ... Porcine Circovirus (PCV) is a single stranded DNA virus (class II), that is non-enveloped with an un-segmented circular genome ... Anti-Porcine circovirus antibody (ab183908) at 1/1000 dilution + Lysate from Sf21 cells, expressing recombinant PCV2 protein by ...
The present invention provides a novel chimeric porcine circovirus infectious DNA clone and live attenuated chimeric virus with ... Porcine Circovirus Type 2 and Porcine Circovirus-Associated Disease, J Vet Intern Med). Observation of severe clinical PCVAD in ... Fine mapping of antigenic epitopes on capsid proteins of porcine circovirus, and antigenic phenotype of porcine circovirus type ... Porcine circovirus (PCV) is a small, non-enveloped DNA virus which belongs to the family Circoviridae (Todd, D. et al., 2005, ...
The term porcine circovirus-associated disease (PCVAD) is currently used to refer to any of these diseases when they are ... Porcine circovirus 2 (PCV2) is currently considered an important etiologic agent of swine and its infection has potentially ... "Fine Mapping of Antigenic Epitopes on Capsid Proteins of Porcine Circovirus and Antigenic Phenotype of Porcine Circovirus Type ... The term porcine circovirus-associated disease (PCVAD) is currently used to refer to any of these diseases when they are ...
... yesterday said it has detected very low levels of DNA from porcine circovirus (PCV) in its Rotateq vaccine, making it the ... yesterday said it has detected very low levels of DNA from porcine circovirus (PCV) in its Rotateq vaccine, making it the ...
Virion Structure of a Circovirus== The virions of a circovirus consist of a capsid that is enveloped. Virions have an ... Canary circovirus, Goose circovirus ==Description and Significance== Circoviruses are very small non-enveloped icosahedral ... Genome Structure== The genome of the circovirus is monomeric. It is unsegmented and contains a single molecule of circular, ... They have been described in pigs (porcine circovirus, PCV), chickens (chicken anemia virua, ChAV), psittacines (psittacine beak ...
Pigeon circovirus (PiCV) (Columbid circovirus). ,p>This subsection of the ,a href="http://www.uniprot.org/help/names%5Fand% ... Viruses › Monodnaviria › Shotokuvirae › Cressdnaviricota › Arfiviricetes › Cirlivirales › Circoviridae › Circovirus › Pigeon ... sp,Q9IG44,ORFC2_PICV Uncharacterized protein ORFC2 OS=Pigeon circovirus OX=126070 GN=ORFC2 PE=4 SV=1 ...
Viruses › Monodnaviria › Shotokuvirae › Cressdnaviricota › Arfiviricetes › Cirlivirales › Circoviridae › Circovirus. ,p>This ... sp,Q91EK2,ORFC2_GOCV Uncharacterized protein ORFC2 OS=Goose circovirus OX=146032 GN=ORFC2 PE=4 SV=1 ... Goose circovirus (GoCV). ,p>This subsection of the ,a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names ...
They have finally isolated the virus , named circo virus. It comes from pigs and birds. The similarities to avian and swine flu ... H1N1 , Bird Flu, and Circo virus in dogs? page: 1 #liveFeed1, #liveFeed2, #liveFeed3 { margin: 40px 2px 50px 4px; width: 280px ... which has been identified as circo virus. ( new virus in dogs) My mind wonders, with the flu vaccine, could this be being ...
CANADA - Porcine Circovirus-2 (PCV-2) has become a major health concern not only in the United States, but in other world ...
J. Segalés, G. M. Allan, and M. Domingo, "Porcine circovirus diseases," Animal Health Research Reviews, vol. 6, no. 2, pp. 119- ... Figure 1: Detection of porcine circovirus type 2 (PCV2) with PCR method. The primers designed on the basis of the ORF2 of the ... S. P. Chen, Y. J. Weng, C. P. Tsai et al., "Identification of pathogenic porcine circovirus in pigs with post-weaning ... J. Kim, H.-K. Chung, and C. Chae, "Association of porcine circovirus 2 with porcine respiratory disease complex," Veterinary ...
J. Segalés, G. M. Allan, and M. Domingo, "Porcine circovirus diseases," Animal Health Research Reviews, vol. 6, no. 2, pp. 119- ... S. P. Chen, Y. J. Weng, C. P. Tsai et al., "Identification of pathogenic porcine circovirus in pigs with post-weaning ... J. Kim, H.-K. Chung, and C. Chae, "Association of porcine circovirus 2 with porcine respiratory disease complex," Veterinary ... S. Cao, H. Chen, J. Zhao et al., "Detection of porcine circovirus type 2, porcine parvovirus and porcine pseudorabies virus ...
Raven circovirus (RaCV), DQ146997; canary circovirus (CaCV), AJ301633); Columbid circovirus (CoCV), AF252610; Gull circovirus ( ... Goose circovirus (GoCV), AJ304456; Duck circovirus (DuCV), DQ100076; Porcine circovirus 1 (PCV1), AY660574; PCV2, AY424401; ... A) Genome organization of dog circovirus (DogCV) and porcine circovirus 2 (PCV2). B) Phylogenetic analysis of DogCV strains ( ... GenBank accession numbers for circoviruses used in the analysis: Finch circovirus (FiCV), DQ845075; Starling circovirus (StCV ...
As of October 3, 2013, circovirus has been confirmed in two dogs that have died in Ann Arbor, Michigan. ... What Species is Circovirus Known to Infect?. Circovirus is currently known to infect birds, dogs, and pigs. Infection in the ... Can Circovirus Be Spread to Humans?. Currently, there have been no reports of humans being infected with circovirus. Yet, as ... How is Circovirus Spread?. Circovirus is commonly spread through body fluid secretions, including those from the digestive and ...
... discusses the emerging canine circovirus (DogCV). This talk was part of the Maddies® Shelter Medicine Conference track of the ...
Porcine circovirus 2 (PCV2) replicates in vivo in a wide variety of cells, including cells of the monocyte /macrophage lineage ...
A new virus called canine circovirus has been blamed for several dog deaths across the U.S. Symptoms include vomiting, diarrhea ... Ask about Circovirus and if your veterinarian has observed cases with these clinical signs. If so, have them contact their ... If you have any questions or concerns or read somewhere that pickle juice cures Circovirus, please ask your vet before taking ... My secret hope is well determine canine Circovirus is really a wimpy virus and reduce it to another trivia question future ...
In 2013, we identified a novel circovirus by degenerate PCR and fully sequenced its genome. This virus differs substantially ... from currently known members of the genus Circovirus and represents a new species. ... Apart from the well-documented pathogenicity of porcine circovirus in pigs, of dog circovirus in dogs, and of other ... Li L, McGraw S, Zhu K, Leutenegger CM, Marks SL, Kubiski S, Circovirus in tissues of dogs with vasculitis and hemorrhage. Emerg ...
It was the second mammalian circovirus species identified in dogs and its role in canine enteritis is still being uncertain as ... Canine Circovirus (CanineCV) is an emerging virus which since its first report in USA in 2012, it has been described worldwide ... Herbst, W. & Willems, H. Detection of virus particles resembling circovirus and porcine circovirus 2a (PCV2a) sequences in ... Dias, A. S. et al. Lack of antibody protection against Porcine circovirus 2 and Porcine parvovirus in naturally infected dams ...
Reports of a newly-identified canine strain of circovirus have set many dog lovers on edge. According to the American ... Circovirus produces symptoms that are common to many illnesses, such as parvo and corona, which can make the virus difficult to ... To date, there have only been a small number of circovirus cases to study, so what is currently known about the virus may ... Reports of a newly-identified canine strain of circovirus have set many dog lovers on edge. According to the American ...
Porcine Circovirus Type 2. PCV2 at a glance. Porcine circovirus type 2 or PCV2 is a very small DNA virus that infects pigs. ...
Ohio Ag Dept issued warning on Canine Circovirus, a contagious disease that has spread, killing 6 more dogs, but is there more ... CIRCOVIRUS VACCINE COMING?. Ohio Ag Dept issued warning on Canine Circovirus, a contagious disease that has spread, killing 6 ... CIRCOVIRUS KILLS DOGS. Is species-jumping Circovirus a forerunner to more new vaccines and bacterial anomalies that can sicken ... Where Did Canine Circovirus Come From?. Some veterinarians are relating circovirus to both parvo and Norovirus (aka Norwalk ...
  • PCV2 is the primary pathogen associated with a spectrum of swine diseases called porcine circovirus-associated diseases that have been described in pigs worldwide. (gopetsamerica.com)
  • The present invention provides a novel chimeric porcine circovirus infectious DNA clone and live attenuated chimeric virus with the PCV2, preferably of subtype PCV2b, capsid gene integrated into a non-pathogenic PCV1 virus genome. (freepatentsonline.com)
  • Porcine circovirus type 2 (PCV2) vaccination of conventional pigs prevents viremia against PCV2 isolates of different genotypes and geographic origins, 2008, Vaccine, 26:1063-1071. (freepatentsonline.com)
  • A chimeric porcine circovirus (PCV) with the immunogenic capsid gene of the pathogenic pcv type 2 (PCV2) cloned into the genomic backbone of the nonpathogenic PCV1 induces protective immunity against PCV2 infection in pigs", 2004, Journal of VIrology, 78(12):6297-6303. (freepatentsonline.com)
  • 1. A nucleic acid molecule of a chimeric porcine circovirus (PCV) comprising a nucleic acid molecule encoding a nonpathogenic chimeric PCV derived from a genomic sequence of Type 1 PCV (PCV1), and at least a portion of an encoding sequence of a capsid protein of Type 2 PCV (PCV2). (freepatentsonline.com)
  • Porcine circovirus 2 (PCV2) is currently considered an important etiologic agent of swine and its infection has potentially serious economic impact on the swine industry worldwide. (scirp.org)
  • The term porcine circovirus-associated disease (PCVAD) is currently used to refer to any of these diseases when they are associated with PCV2 infection. (scirp.org)
  • All five porcine lungs showed typical intraluminal plugs, and porcine circovirus type 2 (PCV2) was identified. (hindawi.com)
  • Postweaning multisystemic wasting syndrome (PMWS) is considered as the essential infection of porcine circovirus type 2 (PCV2). (hindawi.com)
  • A) Genome organization of dog circovirus (DogCV) and porcine circovirus 2 (PCV2). (nih.gov)
  • Porcine circovirus 2 (PCV2) replicates in vivo in a wide variety of cells, including cells of the monocyte /macrophage lineage and cells of epithelial origin. (thepigsite.com)
  • Porcine circovirus type 2 or PCV2 is a very small DNA virus that infects pigs. (iastate.edu)
  • US - In the latest 'At the Meeting' (ATM) audio program on swine health from the Morrison Group, leading swine veterinarians take on the historic and novel work regarding porcine circovirus (PCV2), including prevention, new diagnostic methods and vertical transmission's impact on pig production and sow herds. (thepigsite.com)
  • Postweaning multisystemic wasting syndrome (PMWS) is a recently emerged disease of nursery and grower pigs associated with type 2 porcine circovirus (PCV2) infection. (aasv.org)
  • Encephalomyocarditis virus (EMCV) and porcine circovirus type 2 (PCV2) are common causative agents with high infection rate in pig farms, thus a combined vaccine against both EMCV and PCV2 is highly desirable. (scirp.org)
  • Porcine circovirus type 2 (PCV2) vaccination leads to reduced mortality, increased growth rate, inconsistent effects on feed efficiency and no impacts on carcass traits but the effects on nursery performance are product-dependent, according to Dr Steve Dritz of Kansas State University. (thepigsite.com)
  • Several studies have been conducted to evaluate the efficacy of porcine circovirus type 2 (PCV2) vaccines by using various criteria, including mortality rate, viraemia and co-infections, according to Steve Dritz of Kansas State University. (thepigsite.com)
  • Porcine circovirus type 2 (PCV2), an important porcine pathogen, primarily causing PCV2-associated diseases in pigs [ 13 , 14 ]. (mdpi.com)
  • Porcine circovirus type 2 (PCV2) infection induces autophagy and apoptosis. (mdpi.com)
  • ISU pathologist Darin Madson, DVM, says university research suggests pigs take one of two distinct paths when infected with porcine circovirus type 2 (PCV2). (nationalhogfarmer.com)
  • During a 2-month period a newly repopulated Danish pig herd experienced an increase in numbers of stillborn and mummies, caused by porcine circovirus type 2 (PCV2) associated reproductive failure. (nih.gov)
  • Post-weaning multisystemic wasting syndrome (PMWS) is an important emerging viral disease affecting nursery and grower pigs, which has recently been associated with porcine circovirus type 2 (PCV2) infections. (genetex.com)
  • Porcine circovirus type 2 Capsid antibody didn't detects PCV2 at macrophages on lymph node by immunohistochemical analysis. (genetex.com)
  • Lysate (30 µg) from Sf21 cells, expressing recombinant PCV2 protein by baculovirus system, was separated by 12% SDS-PAGE, and the membrane was blotted with Porcine circovirus type 2 Capsid antibody (GTX128120) diluted at 1:1000. (genetex.com)
  • Larochelle R, Magar R, D'Allaire S (2002) Genetic characterization and phylogenetic analysis of porcine circovirus type 2 (PCV2) strains from cases presenting various clinical conditions. (springer.com)
  • In all litters submitted, porcine circovirus type 2 (PCV2) antigen was identified by immunohistochemistry in fetal heart lesions. (aasv.org)
  • Porcine Circovirus 2 (PCV2) has been intriguing pig producers and scientists alike as it proved difficult to identify both the disease's origins and triggers. (pigprogress.net)
  • The porcine circovirus type 2 (PCV2) is commonly present along with the porcine reproductive and respiratory syndrome virus (PRRSV). (academicjournals.org)
  • It is related to porcine circovirus type 2 (PCV2) - one of the most economically important viruses for the pig production industry worldwide. (bmj.com)
  • Bolin, S. R. 2002-01-01 00:00:00 The kinetics of porcine circovirus type 2 (PCV2) replication in PK15 cells was examined. (deepdyve.com)
  • Porcine circovirus 2 (PCV2) is a serious problem to the swine industry and can lead to significant negative impacts on profitability of pork production. (pubmedcentralcanada.ca)
  • Syndrome associated with PCV2 is known as porcine circovirus closely associated with post-weaning multisystemic wasting syndrome (PMWS). (pubmedcentralcanada.ca)
  • Porcine circovirus type 2 (PCV2) is the essential infectious agent causing porcine circovirus-associated disease (PCVD) in pigs and one of the important viruses that severely jeopardize the swine husbandry industry. (springer.com)
  • Rose N, Opriessnig T, Grasland B, Jestin A (2012) Epidemiology and transmission of porcine circovirus type 2 (PCV2). (springer.com)
  • Tomas A, Fernandes LT, Valero O, Segales J (2008) A meta-analysis on experimental infections with porcine circovirus type 2 (PCV2). (springer.com)
  • Guo LJ, Lu YH, Wei YW, Huang LP, Liu CM (2010) Porcine circovirus type 2 (PCV2): genetic variation and newly emerging genotypes in China. (springer.com)
  • Nauwynck, H. J. 2008-02-01 00:00:00 Treatment of porcine kidney (PK-15) cells with either interferon-gamma (IFN-γ) or endosomal- lysosomal system acidification inhibitors increases replication of porcine circovirus type 2 (PCV2). (deepdyve.com)
  • A total of 472 samples from domestic pigs collected in China from 2015 to 2018 were tested for the presence of porcine circovirus types 2 and 3 (PCV2 and PCV3, respectively) by conventional polymerase chain reaction analysis. (springer.com)
  • Guo LJ, Lu YH, Huang LP, Wei YW, Wu HL, Liu CM (2011) First construction of infectious clone for newly emerging mutation porcine circovirus type 2 (PCV2) followed by comparison with PCV2a and PCV2b genotypes in biological characteristics in vitro. (springer.com)
  • Introduction Real-time PCR tests have been developed to detect and quantify Porcine Circovirus type 2 (PCV2) and Lawsonia intracellularis in pigs' faeces. (dtu.dk)
  • Stimulation of the porcine immune system causes increased replication of porcine circovirus 2 (PCV2) in vivo. (ugent.be)
  • Porcine circovirus type 2 (PCV2), the causative agent of postweaning multisystemic wasting syndrome (PMWS), is a serious economic problem for the swine industry in China. (biomedcentral.com)
  • PCV2 is a member of the genus Circovirus , of the family Circoviridae , the smallest non-enveloped, single-stranded, circular DNA viruses that replicate autonomously in mammalian cells. (biomedcentral.com)
  • Background Porcine circovirus type 2 (PCV2), is nowadays associated with a number of diseases known as porcine circovirus-associated diseases (PCVAD), especially postweaning multisystemic wasting syndrome (PMWS). (oalib.com)
  • Porcine circovirus type 2 (PCV2) is the causative agent of porcine circovirus-associated disease (PCVAD). (biomedcentral.com)
  • Porcine circovirus type 2 (PCV2), a member of the family Circoviridae , is a small, non-enveloped virus with a circular, single-stranded DNA genome. (biomedcentral.com)
  • PCV2 is the causative agent of porcine circovirus-associated disease (PCVAD), which manifests as postweaning multisystemic wasting syndrome (PMWS), reproductive failure, porcine dermatitis and nephropathy syndrome (PDNS), congenital tremors (CT), porcine respiratory disease complex (PRDC), enteritis, and proliferative and necrotizing pneumonia (PNP), among other conditions [ 2 ]. (biomedcentral.com)
  • Porcine circovirus type 2 (PCV2) infection caused PCV2-associated diseases (PCVAD) is one of the major emerging immunosuppression diseases in pig industry. (oncotarget.com)
  • Veterinarians and pork producers can now help prevent Porcine Circovirus Type 2 (PCV2) viremia with the convenience of a single dose. (engormix.com)
  • The porcine Circovirus type 2 (PCV2) is considered an important emerging pathogen in swine production.It has been associated to different syndromes and porcine diseases like the Porcine Dermatitis and Nephropat. (engormix.com)
  • Porcine circovirus type 2 (PCV2) is a small, circular, single-stranded DNA virus that affects pigs worldwide and is economically important to the swine industry. (engormix.com)
  • Porcine circovirus 2 (PCV2) is the primary cause of post-weaning multisystemic wasting syndrome, in which it stimulates a strong IL-8 response that is associated with chronic inflammation as well as lesions in the lymphoid organs. (microbiologyresearch.org)
  • Innate pro-inflammatory and adaptive immune cytokines in PBMC of vaccinated and unvaccinated pigs naturally exposed to porcine circovirus type 2 (PCV2) infection vary with the occurrence of the disease and the viral burden. (microbiologyresearch.org)
  • Sow porcine circovirus type 2 (PCV2) status effect on litter mortality in postweaning multisystemic wasting syndrome (PMWS). (microbiologyresearch.org)
  • Porcine circovirus type 2 (PCV2) causes postweaning multisystemic wasting syndrome (PMWS) in growing pigs but generally requires the presence of other infectious or non-infectious factors to produce the full clinical expression of disease. (slu.se)
  • To determine if adjuvants differ in their ability to trigger lesions associated with porcine circovirus type 2 PCV2. (drseuss5000fingers.info)
  • Lack of an effect of a commercial vaccine adjuvant on the development of postweaning multisystemic wasting syndrome PMWS in porcine circovirus type 2 PCV2 experimentally infected conventional pigs. (drseuss5000fingers.info)
  • Porcine circovirus type 1 (PCV1) can be detected in swine populations, but unlike PCV2 it is not associated with any clinical disease. (zoologix.com)
  • 2006-4-1 · Postweaning multisystemic wasting syndrome (PMWS) affects 5- to 14-week-old piglets and is associated with porcine circovirus type 2 (PCV2) infection (2, 7, 26, 29). (techmaniac.online)
  • 2014-8-8 · Porcine circovirus type 2 (PCV2) has been identified as the essential causal agent of post-weaning multisystemic wasting syndrome, which has spread worldwide. (techmaniac.online)
  • 2013-3-12 · Porcine circovirus type 2 (PCV2), a circular single-stranded (ss) DNA virus, is recognized as the causative agent of postweaning multisystemic wasting syndrome (PMWS). (techmaniac.online)
  • Porcine circovirus-associated diseases (PCVAD), caused by porcine circovirus type 2 (PCV2), threaten the pig industry worldwide. (biomedcentral.com)
  • Porcine circovirus 2 (PCV2) is the causative agent of a whole series of diseases in pigs, called PCV2 diseases (PCVD). (rki.de)
  • Porcine circovirus 2 (PCV2) is well-known in the swine industry, but is there reason to worry about its cousin PCV3? (scoop.it)
  • PCV2 is a DNA virus classified in the Circovirus genus of the Circoviridae family. (thermofisher.com)
  • The purpose of the study reported here was to determine the prevalence of porcine reproductive and respiratory syndrome virus (PRRSV) in pigs affected with post-weaning multisystemic wasting syndrome (PMWS), a disease believed to be caused by porcine circovirus type 2 (PCV2). (mendeley.com)
  • Porcine circovirus type 2 (PCV2) belongs to the family Circoviridae, and is the causative agent of post-weaning multisystemic wasting syndrome (PMWS) in pigs. (krisp.org.za)
  • The invention relates to a novel porcine circovirus type 2 (PCV2) strain. (patentsencyclopedia.com)
  • 3. The porcine circovirus type 2 (PCV2) virus of claim 1, wherein the PCV2 virus is able to cause cytopathic effect (CPE) in PK-15 cell line or its derivative cell lines. (patentsencyclopedia.com)
  • 12. The anti-porcine circovirus type 2 (PCV2) antibody of claim 11, wherein the antibody comprises at least one of a monoclonal antibody, a polyclonal antibody, and a genetically engineered antibody. (patentsencyclopedia.com)
  • 16. The porcine circovirus type 2 (PCV2) test kit of claim 15, wherein the pathogen antigen is deposited on a plate. (patentsencyclopedia.com)
  • [0002] The present invention relates to the field of animal healthcare, particularly to a novel porcine circovirus type 2 (PCV2) strain, an immunogenic composition containing the virus strain, PCV2 test kit, and application of the virus strain. (patentsencyclopedia.com)
  • Porcine circovirus type 2 (PCV2) is the primary causative agent of porcine circovirus-associated diseases in pigs. (openvirologyjournal.com)
  • Porcine circoviral disease (PCVD) and Porcine circovirus associated disease (PCVAD), is a disease seen in domestic pigs. (wikipedia.org)
  • The live attenuated vaccine of the present invention is also effective protecting pigs from porcine circovirus-associated disease (PCVAD). (freepatentsonline.com)
  • Several trials in Kansas have demonstrated that circovirus vaccination improves the performance of growing pigs even on high health farms.On a 300 sow, PRRS negative farm with a history of PCVAD, 235 animals we. (engormix.com)
  • Help is on the way for pork producers battling porcine circovirus associated disease (PCVAD). (engormix.com)
  • Postweaning multisystemic wasting syndrome (PMWS) is now called porcine circovirus disease (PCVD) in Europe, and porcine circovirus associated disease (PCVAD) in North America. (porkgateway.org)
  • A vaccine to provide protection against Duck circovirus has not been approved for use, though research to create one has occurred. (wikipedia.org)
  • Porcine trypsin was used to make a vaccine for the human rotavirus and a California lab discovered circovirus in that human vaccine so it was suspended by FDA. (animalwellnessmagazine.com)
  • May 7, 2010 (CIDRAP News) Merck, the company that makes the most commonly given rotavirus vaccine in the United States, yesterday said it has detected very low levels of DNA from porcine circovirus (PCV) in its Rotateq vaccine, making it the second rotavirus vaccine found to contain PCV. (umn.edu)
  • The AVMA states that there is currently no vaccine or cure for canine circovirus. (lovetoknow.com)
  • There may be a vaccine for Canine Circovirus on the horizon. (thedogplace.org)
  • In this report, the global Porcine Circovirus Vaccine market is valued at USD XX million in 2016 and is expected to reach USD XX million by the end of 2022, growing at a CAGR of XX% between 2016 and 2022. (reportsnreports.com)
  • Circovirus vaccines had gained a strong reputation for reducing mortality and morbidity in a few short years, and recent work had shown vaccine reduces nasal and fecal shedding. (nationalhogfarmer.com)
  • Intervet Inc. announced yesterday the full U.S. Department of Agriculture license for Circumvent PCV (Porcine Circovirus Vaccine, Type 2, Killed Baculovirus Vector), which provides a superior solution for the c. (engormix.com)
  • Thirty-three infants aged ∼2 months had serial stool samples collected after receipt of Rotarix® vaccine dose 1, and were assessed for shedding of porcine circovirus type 1 DNA and Rotavirus group A RNA by molecular methods. (cdc.gov)
  • Differences in virulence among porcine circovirus type 2 isolates are unrelated to cluster type 2a or 2b and prior infection provides heterologous protection", 2008, J Gen Virol, 89(10):2482-2491. (freepatentsonline.com)
  • Our results indicate that circovirus, alone or in co-infection with other pathogens, might contribute to illness and death in dogs. (nih.gov)
  • Infection in the pig world is quite common, as Porcine circovirus 2 can affects piglets shortly after they are weaned (cessation of nursing). (petmd.com)
  • What Are Common Clinical Signs of Circovirus Infection? (petmd.com)
  • Can Circovirus Infection Be Prevented? (petmd.com)
  • Based on initial research conducted at University of California, Circovirus seems to be more of a problem as a secondary infection in dogs. (pethealthnetwork.com)
  • Either they become clinically infected and develop porcine circovirus-associated disease, which can produce 70-80% mortality in finishing pigs, or they develop a subclinical infection with impaired growth and reduced immunity to other disease pathogens or co-infections. (nationalhogfarmer.com)
  • Porcine diseases associated with porcine circovirus 2 (PCV-2) infection have resulted in significant economic losses worldwide. (springer.com)
  • Can porcine circovirus type 3 cause persistent infection in pigs? (bmj.com)
  • Porcine circovirus type 3 (PCV3) is widespread in clinically healthy pigs but the viral load is low, suggesting the presence of subclinical infection. (bmj.com)
  • Dr. Leslie Woods, of U.C. Davis feels that if Pigeon Circovirus holds true to the pattern set by PBFD and CAA, then infection may be by a fecal-oral route. (albertaclassic.com)
  • Bao F, Mi S, Luo Q, Guo H, Tu C, Zhu G, Wang W (2017) Retrospective study of porcine circovirus type 2 infection reveals a novel genotype PCV2f. (springer.com)
  • The main objective of this study was to evaluate the dynamics of porcine circovirus type 2 infection and neutralizing antibodies in gilts subclinically infected and to determine the effect on their litters. (greenworldslimmingcapsule.info)
  • Zhou Y, Qi B, Gu Y, Xu F, Du H, Li X, Fang W. Porcine Circovirus 2 Deploys PERK Pathway and GRP78 for Its Enhanced Replication in PK-15 Cells. (mdpi.com)
  • It was first discovered during a 2012 Columbia University study ( Complete Genome Sequence of the First Canine Circovirus ). (petmd.com)
  • If deemed appropriate, a veterinarian can perform canine circovirus testing through the MSU Diagnostic Center for Population and Animal Health . (petmd.com)
  • There is currently no vaccination available for canine circovirus. (petmd.com)
  • In this short presentation, Dr. Cynda Crawford, DVM, PhD and Clinical Assistant Professor for Maddie's ® Shelter Medicine Program at the University of Florida, discusses the emerging canine circovirus (DogCV). (maddiesfund.org)
  • Other comparable deaths were investigated and canine Circovirus identified. (pethealthnetwork.com)
  • We don't even completely know how canine Circovirus is spread. (pethealthnetwork.com)
  • Canine Circovirus (CanineCV) is an emerging virus which since its first report in USA in 2012, it has been described worldwide. (nature.com)
  • It was the second mammalian circovirus species identified in dogs and its role in canine enteritis is still being uncertain as much as its association in disease with the Canine Parvovirus-2 (CPV-2). (nature.com)
  • Reports of a newly-identified canine strain of circovirus have set many dog lovers on edge. (lovetoknow.com)
  • Ohio Ag Dept issued warning on Canine Circovirus, a contagious disease that has spread, killing 6 more dogs, but is there more to be feared than this virus? (thedogplace.org)
  • Hawkins, who has been tracking what's being called canine circovirus , warns that it can kill in as little as 48 hours from onset of symptoms. (thedogplace.org)
  • says it doesn't resemble canine circovirus that much. (thedogplace.org)
  • Where Did Canine Circovirus Come From? (thedogplace.org)
  • Before you rush to get parvo boosters [2] for your pets, hoping that will somehow protect your dog from canine circovirus, consider this. (thedogplace.org)
  • Canine circovirus (CanineCV) has been detected in some dogs with severe haemorrhagic diarrhoea, but its pathogenic role is unclear. (ovid.com)
  • Information about canine circovirus infections - for veterinarians and their patients. (avma.org)
  • This page answers pet owners' common questions about the recently discovered canine circovirus and its possible role in disease in dogs. (avma.org)
  • Circovirus is a genus of viruses, in the family Circoviridae. (wikipedia.org)
  • It is a single stranded DNA virus (ssDNA).There are currently 43 species in this genus including the type species Porcine circovirus 1. (wikipedia.org)
  • DuCV has been clustered in the Circoviridae family genus Circovirus, according to the eighth report of the International Committee on Taxonomy of Viruses. (wikipedia.org)
  • This virus differs substantially from currently known members of the genus Circovirus and represents a new species. (cdc.gov)
  • They belong to the genus Circovirus of the family Circoviridae . (zoologix.com)
  • Porcine circovirus (PCV), belonging to the family Circoviridae and the genus Circovirus , is the smallest virus with a circular, ambisense, single-stranded DNA genome. (biomedcentral.com)
  • Novel circovirus-related genes were identified and as being related to an unnamed gene of a mosquito circovirus (MCCV) sequence from the USA isolated in 2011, with at least 41% nt identity: this distant relationship suggests that the parent virus might belong to a novel circovirus genus. (frontiersin.org)
  • Duck circovirus (DuCV), a tentative member of the genus Circovirus of the family Circoviridae, was first isolated in Germany in 2003 ( 1 ). (asm.org)
  • Genus Tequatrovirus ( T4virus , T4-ähnliche Viren , en. (wikipedia.org)
  • The Duck circovirus (DuCV) is a type of virus found in ducks. (wikipedia.org)
  • Duck circovirus is a small nonenveloped virus with a monomeric single-stranded circular DNA genome. (wikipedia.org)
  • Scientists have studied the Duck circovirus by using polymerase chain reaction (PCR)-based methods and dot blot hybridisation (DBH) tests. (wikipedia.org)
  • It was found that ducks between the ages of 40∼60 days were more susceptible to Duck circovirus. (wikipedia.org)
  • In this study, YN26/2013, a novel recombinant duck circovirus (DuCV), was isolated from a Muscovy duck in Yunnan Province, southern China. (asm.org)
  • The virions of a circovirus consist of a capsid that is enveloped. (kenyon.edu)
  • source: [http://www.ncbi.nlm.nih.gov/ICTVdb/ICTVdB/00.016.0.01.htm ICTV dB Descriptions]) ==Virion Structure of a Circovirus== The virions of a circovirus consist of a capsid that is enveloped. (kenyon.edu)
  • Circovirus genomes encode two major proteins: replication-associated protein (Rep) and capsid (Cap), responsible for genome replication and particle formation, respectively. (asm.org)
  • Recombinant protein encompassing a sequence within the center region of Porcine circovirus type 2 Capsid protein. (genetex.com)
  • Experimental reproduction of severe disease in CD/CD pigs concurrently infected with type 2 porcine circovirus and porcine reproductive and respiratory syndrome virus," Veterinary Pathology , vol. 38, no. 5, pp. 528-539, 2001. (hindawi.com)
  • Lefebvre D, Costers S, VAN DOORSSELAERE J, Misinzo G, DEPUTTE P, Nauwynck H. Antigenic differences among porcine circovirus type 2 strains, as demonstrated by the use of monoclonal antibodies. (ugent.be)
  • PCVD is caused by porcine circovirus type 2 (PCV-2). (wikipedia.org)
  • Grau-Roma L, Fraile L, Segales J (2011) Recent advances in the epidemiology, diagnosis and control of diseases caused by porcine circovirus type 2. (springer.com)
  • In case of the Porcine circovirus type 1 (PCV1), the rep gene directs the synthesis of two proteins. (kenyon.edu)
  • The replication proteins Rep and Rep' of porcine circovirus type 1 (PCV1) are both capable of introducing and resealing strand discontinuities at the viral origin of DNA replication in vitro underlying genome amplification by rolling-circle replication. (nih.gov)
  • Cheung AK (2003) The essential and nonessential transcription units for viral protein synthesis and DNA replication of porcine circovirus type 2. (springer.com)
  • Realistically, there may never be a vaccination available to prevent dogs from being infected with circovirus. (petmd.com)
  • In 2008, a vaccination programme against porcine circovirus type 2 (PCV-2) was initiated in Austria. (ovid.com)
  • Circovirus ===Species=== Beak and feather disease virus, Canary circovirus, Goose circovirus ==Description and Significance== Circoviruses are very small non-enveloped icosahedral viruses with a single stranded circular DNA genome. (kenyon.edu)
  • Endogenous circoviral elements (CVe) are DNA sequences derived from circoviruses that occur in animal genomes and provide a useful source of information about circovirus-host relationships. (asm.org)
  • Circoviruses are a newly described group that includes Pigeon Circovirus, Psittacine Beak and Feather Disease (PBFD) and Chicken Anemia Agent (CAA). (albertaclassic.com)
  • Porcine circoviruses are classified in the Circoviridae family, which contains two genera, Circovirus and Gyrovirus. (pamfa.org)
  • A. Silva Júnior, O. Valério de Carvalho, L. Henrique Silva Bulos, J. Lopes Rangel Fietto, M. Pires Moraes and M. Rogéria de Almeida, "Porcine Circovirus 2: Immunopathogenesis and Recent Developments in Vaccines," World Journal of Vaccines , Vol. 2 No. 2, 2012, pp. 96-104. (scirp.org)
  • Is species-jumping Circovirus a forerunner to more new vaccines and bacterial anomalies that can sicken both people and pets? (thedogplace.org)
  • In the second of the three-part ATM series on porcine circovirus, the veterinarian panel discusses the role of vaccines and immunity in reducing the impact of disease in growing pigs and in the breeding herd. (thepigsite.com)
  • No matter what type of circovirus is in your herd, the vaccines will provide immunity and reduce lesions, and reduce morbidity and mortality while improving performance. (nationalhogfarmer.com)
  • D. J. An, I. S. Roh, D. S. Song, C. K. Park and B. K. Park, "Phylogenetic Characterization of Porcine Circovirus Type 2 in PMWS and PDNS Korean Pigs between 1999 and 2006," Virus Research, Vol. 129, No. 2, 2007, pp. 115-122. (scirp.org)
  • 3 Since that time, PMWS has been reported in swine-producing countries worldwide, and much has been published about the syndrome and porcine circovirus (PCV). (aasv.org)
  • Experimental reproduction of postweaning multisystemic wasting syndrome (PMWS) in pigs in Sweden and Denmark with a Swedish isolate of porcine circovirus type 2. (slu.se)
  • High amino acid sequence similarity was demonstrated between a potential 33.3-kDa protein product of ORF1 of BFDV and the replicase-associated protein of porcine circovirus (PCV), subterranean clover stunt virus, and faba bean necrotic yellows virus. (nih.gov)
  • Li D, Wang J, Xu S, Cai S, Ao C, Fang L, Xiao S, Chen H, Jiang Y (2018) Identification and functional analysis of the novel ORF6 protein of porcine circovirus type 2 in vitro. (springer.com)
  • A blinded interlaboratory assessment of the diagnostic agreement and accuracy of serologic tests for routine detection of antibodies against Porcine circovirus-2 (PCV-2), including indirect fluorescent antibody tests (IFATs) and enzyme-linked immunosorbent assays (ELISAs) was conducted in 7 North American laboratories. (newportlabs.com)
  • You need info about Pig Circovirus Antibody ELISA Kit or any other Gentaur produtct? (gentaurshop.com)
  • Many pigs affected by the circovirus also seem to develop secondary bacterial infections, like Glässer disease (Haemophilus parasuis), pulmonary pasteurellosis, colibacilosis, salmonellosis and others. (wikipedia.org)
  • The circovirus itself doesn't make the bird ill, other infections do. (pipa.be)
  • Circovirus can also infect birds, causing beak and feather disease in psittacines (such as parrots, parakeets, and cockatiels), infectious anemia in chickens, and often fatal infections in pigeons, canaries and finches. (gopetsamerica.com)
  • Among birds, circovirus infections have been associated with beak abnormalities, lethargy, and anorexia in parrots and pigeons and production losses and death in geese ( 3 , 4 ). (cdc.gov)
  • Many symptoms seen in Circovirus - infected birds are really attributable to disease caused by secondary infections that take hold because Circovirus has suppressed the bird's immune responses. (albertaclassic.com)
  • With these primary target organs, it is not surprising that all pigeons with confirmed Circovirus infections thus far have been one year or less in age. (albertaclassic.com)
  • Additionally, the presence of so many secondary infections in Circovirus - positive flocks can lead to errors in treatment and diagnosis. (albertaclassic.com)
  • Many people are worried about circovirus causing diarrhea because the internet virally spreads information like this about viruses! (animalwellnessmagazine.com)
  • The detection of a circovirus in tissues of dogs expands the known tropism of these viruses to a second mammalian host. (nih.gov)
  • Porcine circovirus is a small, circular, non-enveloped DNA virus that is considered very tough to kill and is often more resistant to disinfectants than enveloped viruses, such as porcine reproductive and respiratory syndrome, states KSU swine researcher Megan Potter, DVM. (nationalhogfarmer.com)
  • Allan GM, McNeilly F, Kennedy S, Daft B, Clarke EG, Ellis JA, Haines DM, Meehan BM, Adair BM (1998) Isolation of porcine circovirus-like viruses from pigs with a wasting disease in the USA and Europe. (springer.com)
  • Liu Q, Wang L, Willson P, Babiuk LA (2000) Quantitative, competitive PCR analysis of porcine circovirus DNA in serum from pigs with postweaning multisystemic wasting syndrome. (springer.com)
  • They have been described in pigs (porcine circovirus, PCV), chickens (chicken anemia virua, ChAV), psittacines (psittacine beak and feather disease virus, PBFD) and pigeons. (kenyon.edu)
  • What Species is Circovirus Known to Infect? (petmd.com)
  • Many species of birds can be infected, as circovirus causes infectious anemia in chickens, and beak and feather diseases in psittacines (budgies, cockatiels, finches, parakeets, and parrots). (petmd.com)
  • In this study, we screened genome assemblies of 675 animal species and identified numerous circovirus-related sequences, including the first examples of CVe derived from cycloviruses. (asm.org)
  • Porcine circovirus 3 (PCV-3) is a recently discovered circovirus species found in domestic pigs and wild boar. (tesisenred.net)
  • Psittacine circovirus (PCV) has been identified in more than 60 psittacine species worldwide in both aviary and wild populations. (massey.ac.nz)
  • Here, we intensively sampled two sympatric parrot populations from Mauritius over a period of 11 years and screened for the circovirus Beak and Feather Disease Virus. (kent.ac.uk)
  • Detection of porcine circovirus type 2, porcine parvovirus and porcine pseudorabies virus from pigs with postweaning multisystemic wasting syndrome by multiplex PCR," Veterinary Research Communications , vol. 29, no. 3, pp. 263-269, 2005. (hindawi.com)
  • Larochelle, R., Bielanski, A., M ller, P. and Magar, R. (2000) PCR Detection and Evidence of Shedding of Porcine Circovirus Type 2 in Boar Semen. (zoologix.com)
  • Porcine Circovirus (PCV) is a single stranded DNA virus (class II), that is non-enveloped with an un-segmented circular genome. (abcam.com)
  • Porcine circovirus is a very small (17 nm), nonenveloped, single-stranded DNA virus. (aasv.org)
  • El Circovirus porcino 3 (PCV-3) es un virus descubierto recientemente en cerdos domésticos y jabalíes. (tesisenred.net)
  • Dinámica de la infección por el circovirus porcino tipo 2 y títulos de anticuerpos neutralizantes en las cerdas de reemplazo subclinicamente infectadas, y el. (greenworldslimmingcapsule.info)
  • Proinflammatory cytokine expression in the lung of pigs with porcine circovirus type 2-associated respiratory disease. (microbiologyresearch.org)
  • Identification of porcine circovirus in tissues of pigs with porcine dermatitis and nephropathy syndrome. (drseuss5000fingers.info)
  • Experimental inoculation of tlpo pigs with porcine reproductive and circivirus syndrome virus and porcine circovirus 2. (drseuss5000fingers.info)
  • Veterinarians believed a relatively common type of virus found in pigs and birds known as Circovirus now posed a threat to dogs. (pethealthnetwork.com)
  • According to the American Veterinary Medical Foundation (AVMA), the virus has been identified in at least one case of illness, but it has not yet been determined whether circovirus works alone or in combination with other pathogens to make dogs sick. (lovetoknow.com)
  • Circovirus produces symptoms that are common to many illnesses, such as parvo and corona, which can make the virus difficult to diagnose without veterinary testing. (lovetoknow.com)
  • More study is needed to determine if the virus can be transmitted through respiratory secretions, as it is with porcine circovirus. (lovetoknow.com)
  • To date, there have only been a small number of circovirus cases to study, so what is currently known about the virus may change as more information is gathered. (lovetoknow.com)
  • Some veterinarians are relating circovirus to both parvo and Norovirus (aka Norwalk Virus) the notorious diarrhea-causing "stomach flu" associated with cruise ships. (thedogplace.org)
  • With virtually no hog farms in the world free of the virus, except two U.S. herds, porcine circovirus has become established as one of the top three economically important swine diseases behind porcine reproductive and respiratory syndrome (PRRS) and Mycoplasmal pneumonia, according to a leading researcher at Iowa State University's (ISU) Veterinary Diagnostic Laboratory. (nationalhogfarmer.com)
  • Porcine circovirus type 3 (PCV3) is a recently described virus belonging to the family Circoviridae. (bmj.com)
  • 2. If this also holds for Pigeon Circovirus, it may be that the only way to salvage an infected flock is to eliminate all young birds for at least a year (ie, let the virus die - out naturally). (albertaclassic.com)
  • Segales J, Kekarainen T, Cortey M (2013) The natural history of porcine circovirus type 2: from an inoffensive virus to a devastating swine disease? (springer.com)
  • El virus fue hallado por primera vez en 2016 mediante estudios metagenómicos, en animales afectados por fallo reproductivo, e inflamación cardíaca y multisistémica. (tesisenred.net)
  • Desde entonces, el virus se ha descrito circulando de forma generalizada en animales con diferentes presentaciones clínico/patológicas como en cerdos sanos. (tesisenred.net)
  • 98%). En conclusión, los resultados obtenidos en esta Tesis proporcionan datos relevantes sobre la epidemiología de este nuevo virus, PCV-3, tanto en cerdos domésticos como en jabalíes. (tesisenred.net)
  • Además, la información filogenética sugiere una baja variabilidad genética de PCV-3, en contraste con otros virus de ADN monocatenario. (tesisenred.net)
  • In the present study, we identified partial viral genes of dengue virus (DENV), a novel circovirus (CCV), densovirus (DNV), Japanese encephalitis virus (JEV), and Wuhan mosquito virus (WMV) in mosquitoes. (frontiersin.org)
  • Recently identified porcine circovirus-like virus P1 has the smallest DNA viral genome. (beds.ac.uk)
  • Porcine circovirus 3 - is it a virus to worry about? (scoop.it)
  • The morphology of the inclusions in the bursa and size of the viral particles are most consistent with circovirus. (elsevier.com)
  • In 2013, we identified a novel circovirus by degenerate PCR and fully sequenced its genome. (cdc.gov)
  • We describe a novel circovirus in mink (mustelids). (cdc.gov)
  • The presence of DENV, JEV, and novel circovirus were confirmed, and JEV was isolated. (frontiersin.org)
  • Brunborg IM, Moldal T, Jonassen CM (2004) Quantitation of porcine circovirus type 2 isolated from serum/plasma and tissue samples of healthy pigs and pigs with postweaning multisystemic wasting syndrome using a TaqMan-based real-time PCR. (springer.com)
  • Hamel AL, Lin LL, Nayar GP (1998) Nucleotide sequence of porcine circovirus associated with postweaning multisystemic wasting syndrome in pigs. (springer.com)
  • Distribution of porcine parvovirus in porcine circovirus 2-infected pigs with postweaning multisystemic wasting syndrome as shown by in-situ hybridization. (microbiologyresearch.org)
  • It is important to note that there is still no evidence to-date that dog circovirus can be transmitted to humans or cause human disease. (gopetsamerica.com)
  • Boehringer Ingelheim Vetmedica Inc. again requests proposals for studies investigating porcine circovirus-associated disease. (avma.org)
  • Collecting data about this emerging disease is important, so please consent to testing for circovirus should your veterinarian deem it appropriate based on clinical suspicion. (petmd.com)
  • You've got to watch out, because PCV2b (the most common circovirus genome causing disease) may be the reason you have clinical diarrhea in your finishing herd. (nationalhogfarmer.com)
  • Disease symptoms seen in birds with Pigeon Circovirus somewhat resemble those seen with PBFD and CAA. (albertaclassic.com)
  • Gillespie J, Opriessnig T, Meng XJ, Pelzer K, Buechner-Maxwell V (2009) Porcine circovirus type 2 and porcine circovirus-associated disease. (springer.com)
  • Kit-Porcine Circovirus ELISA kit, 96 tests Control Disease (Serum)-Genemed Synthesis Inc. (genemedsyn.com)
  • October 2013 - While researchers believe circovirus is involved, they are unsure if it is the primary reason for the mystery disease or if other pathogens are involved. (thepetwiki.com)
  • Organ tissues from sentinel dog (dog 1) and 2 other dogs (dogs 2 and 3) that were positive by in situ hybridization (ISH) analysis for dog circovirus (DogCV). (nih.gov)
  • More recently, a dog circovirus (DogCV) was detected in dogs with vasculitis and/or hemorrhagic diarrhoea in the US. (gopetsamerica.com)
  • DogCV shows many similarities to the porcine circovirus but it is not the same. (gopetsamerica.com)
  • We characterized the complete genome of a novel dog circovirus (DogCV) from the liver of a dog with severe hemorrhagic gastroenteritis, vasculitis, and granulomatous lymphadenitis. (nih.gov)
  • Circovirus is currently known to infect birds, dogs, and pigs. (petmd.com)
  • The family Circoviridae is currently composed of 2 genera, Gyrovirus and Circovirus , each of which has been associated with diseases in birds, pigs, and dogs ( 1 , 2 ). (cdc.gov)